GCF_000686845.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JMLS01000001.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	459,006	480,886

NZ_JMLS01000002.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	cyclic-lactone-autoinducer	156,153	176,716

NZ_JMLS01000003.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	RiPP-like	373,003	384,934

NZ_JMLS01000004.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	terpene-precursor	274,294	295,199
Region 4.2	terpene	327,050	347,832

NZ_JMLS01000005.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	ectoine	87,782	98,165	Medium	ectoine	other:other

NZ_KK366026.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	azole-containing-RiPP	1	17,793

NZ_JMLS01000017.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	azole-containing-RiPP	120,638	144,180

NZ_JMLS01000021.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	lassopeptide	85,792	109,730	High	paeninodin	ribosomal:unmodified
Region 18.2	terpene-precursor	131,779	152,744

NZ_JMLS01000027.1 (Paenibacillus sp. UNC451MF)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	T3PKS	77,823	107,292

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene	459,006	480,886
Region 2.1	cyclic-lactone-autoinducer	156,153	176,716
Region 3.1	RiPP-like	373,003	384,934
Region 4.1	terpene-precursor	274,294	295,199
Region 4.2	terpene	327,050	347,832
Region 5.1	ectoine	87,782	98,165	Medium	ectoine	other:other
Region 13.1	azole-containing-RiPP	1	17,793
Region 14.1	azole-containing-RiPP	120,638	144,180
Region 18.1	lassopeptide	85,792	109,730	High	paeninodin	ribosomal:unmodified
Region 18.2	terpene-precursor	131,779	152,744
Region 24.1	T3PKS	77,823	107,292

No secondary metabolite regions were found in these records:: NZ_KK366024.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000008.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000009.1 (Paenibacillus sp. UNC451MF); NZ_KK366025.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000012.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000013.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000014.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000018.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000019.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000020.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000022.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000023.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000024.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000025.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000026.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000028.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000029.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000030.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000031.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000032.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000033.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000034.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000035.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000036.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000037.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000038.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000039.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000040.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000041.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000042.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000043.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000044.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000045.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000046.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000047.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000048.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000049.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000050.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000051.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000052.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000053.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000054.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000055.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000056.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000057.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000058.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000059.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000060.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000061.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000062.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000063.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000064.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000065.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000066.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000067.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000068.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000069.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000070.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000071.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000072.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000073.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000074.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000075.1 (Paenibacillus sp. UNC451MF); NZ_JMLS01000076.1 (Paenibacillus sp. UNC451MF)

Compact view

NZ_JMLS01000001.1 - Region 1 - terpene

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Location: 459,006 - 480,886 nt. (total: 21,881 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BP97_RS0102015: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Ligases: synthase

BP97_RS34925: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.36	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.36	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L
BGC0001787.3	0.35	ribosomal	suicin 3908	Streptococcus suis
BGC0002346.3	0.35	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000188.5	0.33	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000498.5	0.33	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.33	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000842.5	0.33	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000528.5	0.36	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.36	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L
BGC0001787.3	0.35	ribosomal	suicin 3908	Streptococcus suis
BGC0002346.3	0.35	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000197.5	0.34	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000188.5	0.33	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000498.5	0.33	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.33	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000842.5	0.33	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

BP97_RS0102005: T2TS

Domain 1 (6 - 621): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.26 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.05 out of 26.06

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.06 out of 20.01

Confidence: medium

Additional weak hits (5):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.85 out of 28.14

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.97 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.38 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.01 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
MogR	Repressor of flagellar motility genes

NZ_JMLS01000002.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 156,153 - 176,716 nt. (total: 20,564 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BP97_RS0103895: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Lyases: cyclase

BP97_RS0103935: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	0.37	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001861.4	0.36	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.35	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000433.5	0.24	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000344.5	0.22	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002338.3	0.22	PKS	Sorangipyranone	Myxococcales bacterium
BGC0002296.2	0.20	NRPS, PKS	vatiamide A, vatiamide B, vatiamide C, vatiamide D, vatiamide E, vatiamide F	Moorena producens ASI16Jul14-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001364.3	0.37	ribosomal	cinnamycin B	Actinomadura atramentaria DSM 43919
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001861.4	0.36	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0001863.4	0.35	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000433.5	0.24	NRPS	surfactin	Bacillus velezensis FZB42
BGC0000344.5	0.22	NRPS	entolysin	Pseudomonas entomophila L48
BGC0002338.3	0.22	PKS	Sorangipyranone	Myxococcales bacterium
BGC0002296.2	0.20	NRPS, PKS	vatiamide A, vatiamide B, vatiamide C, vatiamide D, vatiamide E, vatiamide F	Moorena producens ASI16Jul14-2

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.59 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JMLS01000003.1 - Region 1 - RiPP-like

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Location: 373,003 - 384,934 nt. (total: 11,932 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001146.5	0.35	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001145.5	0.32	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001868.4	0.31	other (phenazine)	iodinin	Xenorhabdus szentirmaii DSM 16338
BGC0000603.5	0.30	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000605.5	0.29	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000606.5	0.29	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001640.3	0.29	ribosomal	kocurin	Kocuria rosea
BGC0001221.5	0.27	other (phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0001155.5	0.26	ribosomal	GE2270	Planobispora rosea

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001146.5	0.35	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001145.5	0.32	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001868.4	0.31	other (phenazine)	iodinin	Xenorhabdus szentirmaii DSM 16338
BGC0000603.5	0.30	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000605.5	0.29	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000606.5	0.29	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001640.3	0.29	ribosomal	kocurin	Kocuria rosea
BGC0001221.5	0.27	other (phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0001155.5	0.26	ribosomal	GE2270	Planobispora rosea

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.90 out of 27.18

Confidence: medium

Additional weak hits (11):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.12 out of 20.47

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.54 out of 27.04

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.36 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.78 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.47 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.91 out of 36.54

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.31 out of 26.06

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
NrdR	Represses ribonucleotide reductase encoding genes

NZ_JMLS01000004.1 - Region 1 - terpene-precursor

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Location: 274,294 - 295,199 nt. (total: 20,906 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

BP97_RS0108825: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

BP97_RS0108780: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

BP97_RS0108785: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001594.3	0.39	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000643.3	0.38	terpene	carotenoid	Brevundimonas vesicularis
BGC0001501.5	0.38	other (other)	ambiguine P	Fischerella sp. TAU

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001594.3	0.39	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000643.3	0.38	terpene	carotenoid	Brevundimonas vesicularis
BGC0001501.5	0.38	other (other)	ambiguine P	Fischerella sp. TAU

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BP97_RS0108785: PT_FPPS_like

Domain 1 (36 - 301): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.56 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.23 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.93 out of 24.78

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.93 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MexT	Global virulence regulator

NZ_JMLS01000004.1 - Region 2 - terpene

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Location: 327,050 - 347,832 nt. (total: 20,783 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

BP97_RS0109045: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: kinase

BP97_RS0109065: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Translocases: transporter

BP97_RS0109025: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002285.2	0.37	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000495.5	0.36	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001093.3	0.32	NRPS, PKS	disorazol A	Sorangium cellulosum
BGC0002754.2	0.32	NRPS	hectoramide B	Moorena producens JHB
BGC0001553.5	0.32	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000722.5	0.30	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000804.5	0.29	saccharide	acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03	Streptomyces coelicoflavus ZG0656
BGC0000381.5	0.28	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002657.2	0.28	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0000268.5	0.27	PKS	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002285.2	0.37	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000495.5	0.36	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001093.3	0.32	NRPS, PKS	disorazol A	Sorangium cellulosum
BGC0002754.2	0.32	NRPS	hectoramide B	Moorena producens JHB
BGC0001553.5	0.32	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000722.5	0.30	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000804.5	0.29	saccharide	acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03	Streptomyces coelicoflavus ZG0656
BGC0000381.5	0.28	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002657.2	0.28	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0000268.5	0.27	PKS	Sch-47554, Sch-47555	Streptomyces sp. SCC 2136

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

BP97_RS0109055: PT_phytoene_like

Domain 1 (4 - 207): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → PSPP; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.91 out of 19.26

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.32 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.98 out of 29.51

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.24 out of 32.93

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
SypG	Regulator of biofilm formation and host colonization

NZ_JMLS01000005.1 - Region 1 - ectoine

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Location: 87,782 - 98,165 nt. (total: 10,384 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

BP97_RS0109850: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.79	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.73	other (ectoine)	ectoine	Streptomyces sp.
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000856.3	0.71	other (other)	ectoine	Methylophaga thalassica
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.60	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.79	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.73	other (ectoine)	ectoine	Streptomyces sp.
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000856.3	0.71	other (other)	ectoine	Methylophaga thalassica
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.60	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.60	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.16 out of 27.55

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.61 out of 24.78

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 24.05 out of 30.11

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

Additional weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.32 out of 31.73

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.92 out of 20.01

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.06 out of 23.43

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
MexT	Global virulence regulator

NZ_KK366026.1 - Region 1 - azole-containing-RiPP

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Location: 1 - 17,793 nt. (total: 17,793 nt) Show pHMM detection rules used

Region on contig edge.

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

BP97_RS0133795: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000569.5	0.41	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001849.4	0.40	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0000603.5	0.39	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.37	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000569.5	0.41	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001849.4	0.40	ribosomal	thiovarsolin A, thiovarsolin B, thiovarsolin C, thiovarsolin D	Streptomyces varsoviensis
BGC0000603.5	0.39	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001640.3	0.38	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.37	ribosomal	GE37468	Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.23 out of 27.55

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.67 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.88 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (8):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.12 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.81 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.61 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 99; Score: 142.5; RRE type: Thiopeptide_F_RRE; Location: 7 - 89; Score: 46.9

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_JMLS01000017.1 - Region 1 - azole-containing-RiPP

Download region GenBank file

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Location: 120,638 - 144,180 nt. (total: 23,543 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

BP97_RS0117710: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Isomerases: mutase

BP97_RS36755: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.45	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.5	0.42	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.40	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001640.3	0.40	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.39	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.39	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.45	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0001146.5	0.43	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000607.5	0.42	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001145.5	0.40	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.40	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001640.3	0.40	ribosomal	kocurin	Kocuria rosea
BGC0000605.5	0.39	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.39	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.30 out of 27.78

Confidence: medium

Additional weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.00 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.84 out of 36.54

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 99; Score: 168.0; RRE type: Thiopeptide_F_RRE; Location: 7 - 89; Score: 49.2

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

Core peptide predictions

No core peptides found.

NZ_JMLS01000021.1 - Region 1 - lassopeptide

Download region GenBank file

Download region SVG

Location: 85,792 - 109,730 nt. (total: 23,939 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

BP97_RS0121025: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

BP97_RS0121040: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

BP97_RS0121045: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

BP97_RS0120985: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: synthase

BP97_RS0121030: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.68	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0002150.2	0.53	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.53	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0000571.3	0.51	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002289.2	0.51	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0002825.2	0.49	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002322.3	0.48	ribosomal	citrocin	Citrobacter pasteurii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.68	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0002150.2	0.53	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.53	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0000571.3	0.51	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002289.2	0.51	ribosomal	Leepeptin	Streptomyces leeuwenhoekii
BGC0002825.2	0.49	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002322.3	0.48	ribosomal	citrocin	Citrobacter pasteurii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.44 out of 18.16

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.10 out of 21.84

Confidence: medium

Additional weak hits (2):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 15 - 96; Score: 83.9; RRE type: Streptide_RRE; Location: 28 - 89; Score: 25.5

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
MexT	Global virulence regulator

NZ_JMLS01000021.1 - Region 2 - terpene-precursor

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Location: 131,779 - 152,744 nt. (total: 20,966 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

BP97_RS0121230: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	0.40	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.5	0.33	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001928.2	0.24	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002657.2	0.20	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0002291.3	0.20	PKS	efomycin K, efomycin L	Streptomyces sp. M56
BGC0001590.5	0.19	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5
BGC0000053.5	0.19	PKS	elaiophylin	Unknown. Unclassified.
BGC0000202.5	0.19	PKS	azicemicin B	Kibdelosporangium sp. MJ126-NF4
BGC0000151.5	0.18	PKS, saccharide	stambomycin A, stambomycin B, stambomycin C, stambomycin D	Streptomyces ambofaciens ATCC 23877

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	0.40	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.5	0.33	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001928.2	0.24	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002657.2	0.20	NRPS, PKS	deoxyhangtaimycin	Streptomyces spectabilis
BGC0002291.3	0.20	PKS	efomycin K, efomycin L	Streptomyces sp. M56
BGC0001590.5	0.19	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5
BGC0000053.5	0.19	PKS	elaiophylin	Unknown. Unclassified.
BGC0000202.5	0.19	PKS	azicemicin B	Kibdelosporangium sp. MJ126-NF4
BGC0000151.5	0.18	PKS, saccharide	stambomycin A, stambomycin B, stambomycin C, stambomycin D	Streptomyces ambofaciens ATCC 23877

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

BP97_RS0121230: PT_FPPS_like

Domain 1 (34 - 294): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.27 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.56 out of 30.25

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.94 out of 23.79

Confidence: medium

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.49 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.30 out of 29.38

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.91 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.50 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism

NZ_JMLS01000027.1 - Region 1 - T3PKS

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Location: 77,823 - 107,292 nt. (total: 29,470 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene details

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Gene overview

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NRPS/PKS domains

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

BP97_RS0124910: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BP97_RS0124965: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

Hydrolases: hydrolase

BP97_RS0124875: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

BP97_RS0124930: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: synthase

BP97_RS0124950: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

BP97_RS0124955: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter

BP97_RS0124980: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.50	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002403.2	0.49	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0001831.3	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000244.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0002007.2	0.41	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0001964.2	0.39	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000594.5	0.37	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8
BGC0000197.5	0.36	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000679.5	0.36	terpene	diazepinomicin	Micromonospora sp. M42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.50	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0002403.2	0.49	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0001831.3	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0000244.4	0.41	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus
BGC0002007.2	0.41	terpene	atolypene A, atolypene B	Amycolatopsis tolypomycina
BGC0001964.2	0.39	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0000594.5	0.37	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8
BGC0000197.5	0.36	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000679.5	0.36	terpene	diazepinomicin	Micromonospora sp. M42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.55 out of 21.55

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.26 out of 32.93

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.84 out of 33.14

Confidence: medium

Additional weak hits (8):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.85 out of 28.14

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.93 out of 29.72

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.83 out of 29.38

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.18 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.77 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.96 out of 23.43

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor
ZuR variant 2	Zinc-responsive repressor