LOCUS       NZ_JMLS01000005        10384 bp    DNA     linear   CON 10-FEB-2024
DEFINITION  Paenibacillus sp. UNC451MF BP97DRAFT_scaffold00005.5_C, whole genome
            shotgun sequence.
ACCESSION   NZ_JMLS01000005
VERSION     NZ_JMLS01000005.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Paenibacillus sp. UNC451MF
  ORGANISM  Paenibacillus sp. UNC451MF
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 359632)
  AUTHORS   Dangl,J., Huntemann,M., Han,J., Chen,A., Kyrpides,N., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (24-APR-2014) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Paenibacillus sp. UNC451MF
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi0054671
            Gene Calling Method               :: Prodigal 2.5
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2014-04-01
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/10/2024 01:27:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,772
            CDSs (total)                      :: 6,708
            Genes (coding)                    :: 6,634
            CDSs (with protein)               :: 6,634
            Genes (RNA)                       :: 64
            rRNAs                             :: 4, 3 (5S, 16S)
            complete rRNAs                    :: 4 (5S)
            partial rRNAs                     :: 3 (16S)
            tRNAs                             :: 53
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 74
            CDSs (without protein)            :: 74
            Pseudo Genes (ambiguous residues) :: 0 of 74
            Pseudo Genes (frameshifted)       :: 18 of 74
            Pseudo Genes (incomplete)         :: 59 of 74
            Pseudo Genes (internal stop)      :: 15 of 74
            Pseudo Genes (multiple problems)  :: 15 of 74
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:46:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 87781
            Orig. end                         :: 98165
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JMLS01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..10384
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10384
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10384
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5384](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5384
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            61..948
                     /gene="ehuB"
                     /locus_tag="BP97_RS0109825"
     CDS             61..948
                     /GO_component="GO:0009897 - external side of plasma
                     membrane [Evidence IEA]"
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033294 - ectoine binding [Evidence IEA]"
                     /GO_function="GO:0033295 - hydroxyectoine binding [Evidence
                     IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006212832.1"
                     /locus_tag="BP97_RS0109825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine/hydroxyectoine ABC transporter
                     substrate-binding protein EhuB"
                     /protein_id="WP_028548942.1"
                     /transl_table=11
                     /translation="MLFLTLLTSVVGCGEVREANTGGGNTSKQESGAGNDTLAKVKQQG
                     FVTVGFANEKPYAYKTSDGQLTGEAVEIARIVLDKLGIKEMKGELTEFGSLVGGLQAKR
                     FDMITAGMFINAQRCQAVLFANPEYSIGEAIAVSKGNPQGLRSYKDIADKKDMKVAVMT
                     GAIEIGYLEKSGVTKEQMVLVPDQASALNALQANRAQAVTMTGPALQAMLDSAKDSSLE
                     RVADFEQPVIDSKSVRGYGATAFRPEDKSFQEAFNAELKKLKDSGELLTILKKFGFTEQ
                     ELPGDLTSEALCKE"
     gene            950..1603
                     /gene="ehuC"
                     /locus_tag="BP97_RS0109830"
     CDS             950..1603
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuC"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015737576.1"
                     /locus_tag="BP97_RS0109830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuC"
                     /protein_id="WP_028548943.1"
                     /transl_table=11
                     /translation="MITSWMEFIPLLMQGAKITVEIAFLSSVAALVVSLVTGLCRLSKL
                     RIIRFLASVYVEFFRGSSLLIQLFWMYFALPFIGIELPKLIAAVIAFCLNYGAYGSEIV
                     RSSIDAIPGGQWEAGKALNMKYRQTLVHIVLPQAFVRMLPPFGNLLIELIKGTSLVYFI
                     TLADLTYQAMVLRNNYISWSPQILVLLLLIYFAIASLVSFVMRFAERKIAAGRM"
     gene            1610..2329
                     /gene="ehuD"
                     /locus_tag="BP97_RS0109835"
     CDS             1610..2329
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuD"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018707611.1"
                     /locus_tag="BP97_RS0109835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuD"
                     /protein_id="WP_028548944.1"
                     /transl_table=11
                     /translation="MWNWDYALQILPELLKALQVTLLATCCGFAIACIGGLLLALAAAS
                     RWFLLSTVSRWLVEFIRSTPLLVQIFFLYYTLPKIANISLPAFAVGIIGLGLHYSTYMS
                     EVYRSGIEAVPKGQWEAAVALNFPKVKTWITIILPQAIPPIIPVMGNYLLVMFKETPVL
                     SAITLVEMLLTAKNIVSESYRVFEPYTMVGILFLIISYPASVLIRLLEKRLNLQPGQRS
                     TGKQAQESLSSKKEVGA"
     gene            2326..3096
                     /gene="ehuA"
                     /locus_tag="BP97_RS35800"
     CDS             2326..3096
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transport
                     [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transport [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010269278.1"
                     /locus_tag="BP97_RS35800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine/hydroxyectoine ABC transporter
                     ATP-binding protein EhuA"
                     /protein_id="WP_051620481.1"
                     /transl_table=11
                     /translation="MKPIVKYSEVSKSFGDLEVLKHIDLEIAPGEKLAMIGPSGSGKTT
                     LGRMLMTLEEPTSGTIELDGEMLWHMQIRDQLIRANEKHLHRMRGKVGMVFQHFNLFPH
                     MNVLRNVTEAPRKVLGLSKEEAEDRAVTMLGKVGLQDKLHVYPAQLSGGQKQRVAIARA
                     LVMRPMVMVFDEVTSALDPELVGEVLEVIREIAEEGDMAMMLITHEMDFAKEIADRVVF
                     GAEGRIVEQGPPEAIFENPQSDRLQSFLKRFRSS"
     gene            3128..3625
                     /gene="ectA"
                     /locus_tag="BP97_RS0109845"
     CDS             3128..3625
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015737574.1"
                     /locus_tag="BP97_RS0109845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_036745685.1"
                     /transl_table=11
                     /translation="MRTEAEIRYRKPVQEDGRLVWKLVKQTETLDVNSVYCYILLCDYF
                     KDSCIVAEDEDGIVGFVSAFRTPENPERLFVWQIAVAPDKQRRGIGKKLLSELLSAKCC
                     RGIRYLETTISPSNLASRGLFLELAKQRGLECRLSQGYTASSFPQEHHHEEEILFCLGP
                     IS"
     gene            3670..4962
                     /gene="ectB"
                     /locus_tag="BP97_RS0109850"
     CDS             3670..4962
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (31-367). E-value: 1.4e-74.
                     Score: 243.1. Matches aSDomain:
                     nrpspksdomains_BP97_RS0109850_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020616106.1"
                     /locus_tag="BP97_RS0109850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_028548946.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.5e-78, bitscore:
                     258.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKMPTLEMPSMQVFEEMESEVRSYCRSFTTVFEKAKNAKLWDKNG
                     NEYIDFFAGAGALNYGHNNDRIREKLLDYLLKDGVTHSLDMATSAKEHFLTRFNEVILK
                     PRKLGYKVMFPGPTGTNAVESALKIARKVTGRTSVICFTNAFHGMSLGSLAITGNSFKR
                     KGAGVELGNAVFMPYDGYFGEEMDTSRYIEKLLDDPGSGISLPAAVILETVQGEGGLNV
                     ASQKWLRSIEALCRKRGILLIVDDVQMGCGRTGAFFSFDGSGLEPDIVCLSKSIGGYGL
                     PMALTLLKPDIDQWSPGEHNGTFRGNNLGFVAATEALRYWEDDRLNQEITMKSRLIRTS
                     LGNMLASRPELQGEIRGKGMIQGIAFQQDGMAERLCARVFARGLIMETSGPRSEVAKLM
                     PPLTIGGEELEKGLRILAEEMSKLPVVDENK"
     aSDomain        3763..4770
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BP97_RS0109850_Aminotran_3.1"
                     /evalue="1.40E-74"
                     /label="BP97_RS0109850_Aminotran_3.1"
                     /locus_tag="BP97_RS0109850"
                     /protein_end="367"
                     /protein_start="31"
                     /score="243.1"
                     /tool="antismash"
                     /translation="FEKAKNAKLWDKNGNEYIDFFAGAGALNYGHNNDRIREKLLDYLL
                     KDGVTHSLDMATSAKEHFLTRFNEVILKPRKLGYKVMFPGPTGTNAVESALKIARKVTG
                     RTSVICFTNAFHGMSLGSLAITGNSFKRKGAGVELGNAVFMPYDGYFGEEMDTSRYIEK
                     LLDDPGSGISLPAAVILETVQGEGGLNVASQKWLRSIEALCRKRGILLIVDDVQMGCGR
                     TGAFFSFDGSGLEPDIVCLSKSIGGYGLPMALTLLKPDIDQWSPGEHNGTFRGNNLGFV
                     AATEALRYWEDDRLNQEITMKSRLIRTSLGNMLASRPELQGEIRGKGMIQGIAFQ"
     gene            5001..5384
                     /locus_tag="BP97_RS0109855"
     CDS             5001..5384
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020616105.1"
                     /locus_tag="BP97_RS0109855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_028548947.1"
                     /sec_met_domain="ectoine_synt (E-value: 8.1e-52, bitscore:
                     168.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVKHLDQLINTVDDVDTTTWNSRRLLLRKDGMGFSMNDTLIKAG
                     TETLIWYQNHVEAVYCVEGEGEIEVIGGETYKIKPGMLYALDGHERHFLRAKSQMRMIC
                     VFNPPLVGQEVHDESGTYPLIKD"
     gene            5398..6303
                     /gene="thpD"
                     /locus_tag="BP97_RS0109860"
     CDS             5398..6303
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010269269.1"
                     /locus_tag="BP97_RS0109860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_028548948.1"
                     /sec_met_domain="PhyH (E-value: 2.1e-39, bitscore: 130.2,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSMNAVSDTNQRQDLYPSRISEQPVIIDRKDPVVYSKWNPASGI
                     SQEQSDFYHQQGYLFIESFFSPAEVNEYRDELKRLWTTSRQSDTSEVIREPDSEEVRSI
                     FNVHRSNAVFQALSNHSKLKNIVDYILGSPTYIHQSRINFKPGFTGKEFYWHSDFETWH
                     VEDGMPRMRALSCSIALEDNYPFNGPLMVVPGSHKDFVACVGQTPDDHYKNSLRRQQYG
                     VPDQDSLTALVKQYGIETPVGKAGSIVLFDCNIMHGSSSNISPMPRSNVFLVYNSIENK
                     LQTPYSGQRPRPDFIASRDE"
     regulatory      6369..6504
                     /bound_moiety="cyclic di-AMP"
                     /db_xref="RFAM:RF00379"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00379"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="cyclic di-AMP (ydaO/yuaA leader) riboswitch senses
                     the signaling molecule cyclic di-AMP; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            6851..8026
                     /locus_tag="BP97_RS0109865"
     CDS             6851..8026
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019424746.1"
                     /locus_tag="BP97_RS0109865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="KamA family radical SAM protein"
                     /protein_id="WP_028548949.1"
                     /transl_table=11
                     /translation="MPQPKYITDINKIQEIPEQDRIKLQQITDKFVFRVNDYYLKLIDW
                     NDPNDPIKKLVIPNEGELSEYGRWDASDEDTNYVVPGCQHKYKTTALLIVSEVCGAYCR
                     YCFRKRLFRNDVKEAMSDVNPGLEYIAEHSEINNVLLTGGDSLILATSKLASILERLRA
                     IEHVKIIRLGSKIPVFNPMRIYEDEQLLETIRKYSTADKRIYVMAHINHPREITEEAKR
                     GFEALHQAGAIVVNQTPILRGINDHPAVLAELLDKLSWAGVTPYYFFINRPVAGNRDFV
                     LPLSEVYRIVEQAKARTSGLGKRIRLSMSHTSGKIEILAIENGKAYLKYHQSREDQYGK
                     FMIMDCPKDAAWFDDLPGSEQHWKQPTKKSDSIISANELPDMPQGRSLTLS"
     misc_feature    8036..8052
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 22.16"
                     /tool="antismash"
     misc_feature    complement(8123..8136)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.61"
                     /tool="antismash"
     gene            8180..8890
                     /locus_tag="BP97_RS0109870"
     CDS             8180..8890
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006037396.1"
                     /locus_tag="BP97_RS0109870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_028548950.1"
                     /transl_table=11
                     /translation="MFLRSVQIMKQQFPNKSAYPFSIPALREVESIAFQGNVTFFVGEN
                     GSGKSTILEAIAYQCGFNTAGGGRNNFYEVDASSSSLGNYVRLSWMPKITNGFFLRAET
                     FYQFASHIDEMPESLRYYGGRSLHAQSHGEAFLSLFQHRFGKKAIYLLDEPEAALSPAR
                     QLALLRIMKDLEKEAQFIVATHSPILLGYPDAQILDFDRSPIKSIRYEDTLHYIVTRRF
                     LENKKAVLAELFSE"
     misc_feature    complement(8918..8934)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.32"
                     /tool="antismash"
     misc_feature    9271..9285
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 24.05"
                     /tool="antismash"
     misc_feature    complement(9715..9728)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.92"
                     /tool="antismash"
     misc_feature    10095..10108
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.06"
                     /tool="antismash"
     misc_feature    10281..10295
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.86"
                     /tool="antismash"
ORIGIN
        1 ttcgcgcgaa cgtattctta agagaggttg tgatgctgct tgagaaggag tttagcgata
       61 atgctgtttc taacgcttct cacatcagtc gtcggttgcg gggaagtccg cgaggccaat
      121 accggaggcg gaaatacgag caaacaggag tctggggcgg gtaatgacac attagccaaa
      181 gtgaagcaac aaggcttcgt tacggtaggc tttgccaacg agaagccata cgcctacaag
      241 acatccgacg gtcaattgac aggagaagca gtagaaattg cccggattgt tctcgacaaa
      301 ctgggtatca aagaaatgaa gggtgagctg acggaattcg gatctttggt cggcggcctt
      361 caagccaagc gatttgatat gattacggca gggatgttca tcaacgctca acgctgtcag
      421 gcggttctct tcgccaatcc agaatacagt attggggaag ctattgcggt ttccaaaggg
      481 aatcctcaag gacttcgtag ctacaaggac atcgcagata agaaggatat gaaagtcgcc
      541 gtcatgacgg gcgctattga aatcggctat ttggaaaaat caggcgttac gaaggagcaa
      601 atggtgcttg tgccggatca agcttcagca ttaaatgctt tacaggctaa ccgggcacag
      661 gccgttacga tgacggggcc tgcacttcaa gcaatgctgg actccgccaa agatagcagc
      721 ctggagagag tcgcagattt tgaacagccc gttatagact cgaagagtgt aagaggctat
      781 ggtgcaacgg catttcgtcc tgaggataag tcgtttcagg aagcttttaa tgcagagctt
      841 aagaagctga aggactcagg ggagcttctt acgatactga agaaattcgg atttaccgag
      901 caggagcttc ccggggattt gacctctgaa gctttatgca aggagtaata tgattacttc
      961 ttggatggaa tttatccctc tgctgatgca gggggctaag ataacggtag aaatagcatt
     1021 cctttcctca gtagctgcat tagtcgtttc gcttgtcacc ggtttatgca ggttatccaa
     1081 gctgaggatc ataagatttc ttgcatcggt gtacgtcgag ttttttcggg gaagttccct
     1141 gcttattcaa ttattctgga tgtattttgc tcttccgttc atcgggattg agctccccaa
     1201 gctgattgct gcggttattg ctttctgttt gaattatggg gcttatggat cggaaattgt
     1261 gcgcagctcc atagatgcaa ttcctggtgg tcaatgggag gccggtaaag ctctgaatat
     1321 gaaatatcgg caaacgttgg tccacatcgt attaccccaa gccttcgtaa gaatgctgcc
     1381 cccgttcggc aatctgctta tagaactgat taaaggaaca tcgcttgttt attttattac
     1441 gctagcggac ttaacgtatc aagctatggt gctaagaaat aattacatct cttggtcacc
     1501 gcaaatttta gtgcttctgc ttttgattta ttttgctatt gcctctctgg tatccttcgt
     1561 gatgcgtttt gcagaacgaa aaatcgctgc agggaggatg taaaagcgta tgtggaattg
     1621 ggattacgcg cttcaaatct tgcctgagct tctaaaagca ttacaggtca cgcttcttgc
     1681 tacttgctgc ggctttgcca ttgcttgtat cggcggactg cttcttgctc tggctgcagc
     1741 ttcaagatgg tttttgctgt cgaccgtatc gcgttggctg gtggaattta ttcgcagcac
     1801 accgttactg gtacaaatct ttttcttgta ttataccctc cctaaaattg cgaatatttc
     1861 tttacctgct tttgctgtgg ggatcatagg attgggactg cattacagca cttatatgtc
     1921 agaggtatac cgctccggaa tcgaagccgt acctaaggga caatgggaag cggcagtggc
     1981 cttgaatttt ccgaaagtaa aaacatggat aacgattatt ttacctcaag ccattccgcc
     2041 tattattccc gtgatgggaa actacttgct ggtcatgttc aaagagaccc ctgttctatc
     2101 tgccattacc ttggttgaaa tgctgctcac cgccaaaaac atcgtatcgg aatcataccg
     2161 cgtattcgag ccttatacca tggtaggtat tctattctta attattagtt atcctgcatc
     2221 ggtccttatt cgcctactgg aaaaacgttt gaatcttcaa ccgggccagc gttctacagg
     2281 gaagcaagca caagaaagct taagctctaa gaaggaggtg ggagcttgaa gcctatagtg
     2341 aaatattccg aagtaagcaa gtcattcggg gatttggaag tattgaagca tattgatttg
     2401 gaaatcgcgc caggagagaa gctggctatg atcggtccaa gcggttcggg gaaaacgaca
     2461 cttggaagaa tgctcatgac cctagaggaa cccacttctg gaacgattga attggatgga
     2521 gagatgctct ggcatatgca gatccgtgat cagctaattc gagccaacga aaagcacctg
     2581 catcgaatga ggggaaaagt ggggatggtg tttcagcatt ttaatctatt tccccatatg
     2641 aatgtactgc gcaatgtgac ggaggctccg cgtaaggtgc tggggttgtc caaggaagaa
     2701 gcggaagaca gggctgtaac gatgcttggc aaggtggggc ttcaagacaa gcttcatgtg
     2761 tatccggctc agctatccgg cggccaaaag cagcgggttg ctattgcacg tgctctagtc
     2821 atgcgtccca tggttatggt gttcgacgaa gtcacctcgg ccctggaccc ggagctggtc
     2881 ggtgaagtgc tcgaggtcat tcgcgagatc gcagaagagg gcgacatggc gatgatgctg
     2941 atcacccatg agatggattt tgccaaggag atagctgatc gagtcgtctt tggagcggaa
     3001 ggacgtatcg ttgaacaggg tcctcctgag gccatattcg aaaatccgca gagcgatagg
     3061 ctgcagtcat ttctcaaaag attccgttca tcttaaaaaa acagaacaga aaggagtgtc
     3121 ctgttcgatg agaacagaag cggagattcg ttatcgcaag cctgtccaag aagacgggag
     3181 actcgtgtgg aagcttgtaa agcaaacgga aacactggac gttaattcgg tctattgcta
     3241 catcctgctg tgcgattatt tcaaggatag ctgtatcgta gccgaggatg aggacggtat
     3301 cgtaggcttt gtgtcggcat tccgaacacc ggagaatccc gagcgtctgt ttgtttggca
     3361 gattgcggtt gctccagata agcaaagaag agggataggc aagaagctgc tcagcgagct
     3421 gctatcagcg aaatgctgca gaggaattcg ttatttggaa acgacaatca gcccttcgaa
     3481 cctagcttca aggggattgt ttctggagct ggccaaacaa cgcgggctcg aatgccgctt
     3541 atctcaagga tatacggcat cctcatttcc acaggagcac caccatgagg aagaaatctt
     3601 gttttgttta ggaccgatat cgtagaacag atgtgaacga gaaaatatat ggattatggg
     3661 aggaaaccga tgaaaatgcc tacgctggaa atgccctcta tgcaagtttt tgaagagatg
     3721 gaatccgagg ttcgcagtta ctgccgcagc tttacaacgg ttttcgaaaa agctaaaaat
     3781 gccaagttgt gggataaaaa cggcaatgaa tacattgatt tttttgccgg cgcaggggca
     3841 ttgaattacg ggcataacaa tgatcggatc cgtgagaagc tgctcgacta tttactgaag
     3901 gatggagtta cgcacagtct ggatatggcg acaagcgcca aagagcattt tttaaccagg
     3961 tttaacgagg tgattcttaa accaagaaag ttaggctata aggtgatgtt tccaggacca
     4021 accggtacga atgcagtaga aagtgcgctc aaaatcgctc gcaaggtgac aggaagaaca
     4081 agtgtaattt gttttactaa cgcgtttcac gggatgtcgc taggatcgct tgcaataaca
     4141 ggtaactcgt tcaaacgaaa aggcgctgga gtggagctcg ggaatgctgt attcatgccg
     4201 tatgatggct actttggcga agagatggac acctctcgtt acatagagaa gctgctggac
     4261 gatccgggga gcggaattag tttgcctgct gcggtcatac tcgaaacggt gcaaggagaa
     4321 ggcgggctaa acgttgctag tcaaaagtgg cttagaagca tagaagcgct gtgcagaaaa
     4381 agaggaattt tactcatcgt ggatgatgtt caaatgggat gcggacgtac cggagctttc
     4441 ttcagcttcg atgggtcagg tctggagccg gatatagtgt gtctgtccaa atcgatagga
     4501 ggatatgggc tgcctatggc gctgacgctg ctaaaaccgg atatcgatca atggagtcct
     4561 ggcgagcaca acggtacctt tcgtgggaac aaccttggat tcgtggctgc cactgaggcg
     4621 cttcggtact gggaagatga taggcttaac caagagatca cgatgaaaag caggcttata
     4681 cgtacgtcct tggggaatat gctggcaagt cgcccggagc tgcaagggga aattcgtggc
     4741 aaagggatga ttcaaggaat cgcttttcaa caggacggta tggcggaacg gttgtgtgca
     4801 cgcgtatttg ccagaggatt aatcatggag acgtccggtc cccgcagtga agtggcgaag
     4861 cttatgcctc cgttgacgat agggggagaa gagcttgaaa aggggcttcg catacttgct
     4921 gaagaaatgt ctaaattgcc ggttgttgat gagaataagt gaaccataat cttggataac
     4981 aaacaaggag cggataacct atgattgtta aacacttgga tcaattgatc aatacggtag
     5041 acgatgtgga tacaacgacc tggaactcaa ggagactgct gttgcgcaag gatggcatgg
     5101 ggttttcaat gaatgatacg ttaattaaag cgggtacgga aacgttgatt tggtatcaaa
     5161 atcatgtgga ggcggtctat tgtgtagaag gtgaagggga gattgaggtt atcggcgggg
     5221 aaacgtataa gattaagccc ggtatgctgt acgcactaga cggacacgag aggcattttt
     5281 tacgagcgaa atcccaaatg agaatgatct gcgtattcaa tccaccgcta gtcgggcagg
     5341 aagtacatga tgaaagtgga acatacccat taatcaagga ctaagggagg aaatcaaatg
     5401 aagagcatga atgctgtaag cgatacgaat caaaggcagg acctctaccc ttcacgaatt
     5461 tctgaacaac ctgtcattat tgatcgtaaa gaccccgtag tgtattctaa gtggaacccg
     5521 gcgagtggca tcagccaaga acagtcggat ttttatcatc agcagggtta tttatttatt
     5581 gaatcctttt tttcgcccgc ggaagtgaac gaataccgag atgaattgaa gcgactatgg
     5641 acaacgagtc gtcaatctga tacgagcgaa gtcatccggg aaccggatag cgaagaagtt
     5701 agatctatat tcaacgttca tcggagcaac gctgtgtttc aggctttatc gaatcattcg
     5761 aagctcaaaa acattgtcga ttacattttg ggaagtccga cctacatcca tcaatcacga
     5821 attaacttta aacctggttt tacagggaag gagttttact ggcattctga ttttgaaaca
     5881 tggcacgtcg aggatgggat gccacgaatg agggctctga gctgttccat tgcgctggaa
     5941 gataactatc cgtttaacgg accgcttatg gtagtccctg gttctcataa ggattttgta
     6001 gcctgcgtcg gtcagactcc ggatgatcac tacaaaaatt cacttcgtcg tcaacagtac
     6061 ggcgtgcctg atcaggacag tctcactgca ttggtgaaac aatatgggat cgagactcct
     6121 gtgggcaaag caggttctat cgtcttattc gattgcaaca ttatgcacgg gtcgagcagc
     6181 aacatctcgc caatgccgag aagtaatgtg tttttagtat ataacagtat tgaaaacaaa
     6241 ctgcaaacgc cttattcagg ccagcggcct agaccggatt ttatcgcatc acgagatgaa
     6301 taatcgttag atcaatctaa accaataatt tcttgataca atttgacgca tccctgaccg
     6361 tagtgtatga tagtagtacg cttaatttcc ggtttattta tcggaaagcg ggggaaccac
     6421 tttttggggc gaatcatgaa gtatatgtag ggaaccatct ttcccgagcc cggcagctaa
     6481 cctcgtcagc agtggatggg tcaacgtttt tttatgcatc attattgcat tcattgaccc
     6541 gtattccggg tcttttttat attgttggac ggacccggtt gatagcaatt ggacgcctac
     6601 gctggactgt gtattacggt cgcggtgtta tggccctgtt gctgaacggg tctttttgtt
     6661 gtcgtaataa ccaataatta tcatttatta cttattttgt aattttaatc atcatactaa
     6721 agatgaagga gtgatgtggc aacccctttg agggcctatg atgagcagtt cgacgatgaa
     6781 gtatagctcg tgggaaaagt aaggtgaacg ttgtagtcaa aaaaatctgt cattccaagg
     6841 aggatcatca atgccgcaac cgaaatatat taccgatatt aataaaatcc aggaaatacc
     6901 tgagcaggac agaataaagc tgcagcaaat aacggataag ttcgtgtttc gcgtgaacga
     6961 ttattacctg aagctgatag attggaacga tcccaacgat cctatcaaga agctggtcat
     7021 tccgaacgaa ggtgagctat ctgaatacgg ccgatgggat gcatctgacg aagatacgaa
     7081 ctacgtagtg cctggatgcc agcataaata taagacgacg gcgctactta ttgtatcaga
     7141 agtgtgcggc gcctattgtc gttactgctt ccgcaaacgc ttatttcgga atgatgtcaa
     7201 agaagcaatg tcggatgtca acccagggct agagtatatt gcagagcatt ctgaaatcaa
     7261 taatgtgttg ttgacgggcg gagatagctt gattcttgca acatccaagc ttgcctccat
     7321 attggaaaga ctaagagcaa ttgagcatgt gaaaattatc cgactaggtt caaagattcc
     7381 tgtgtttaat ccgatgcgaa tttatgaaga tgagcagctg ctcgaaacca ttcgtaaata
     7441 ttccaccgct gacaagcgca tttatgtcat ggcccacatt aaccacccgc gcgaaataac
     7501 agaggaagcg aagcgaggct tcgaggcgct gcatcaagca ggtgccattg ttgtcaatca
     7561 aacgccgatt ctaagaggta tcaacgatca tccggctgta ttggccgaac tgctcgacaa
     7621 gctatcgtgg gcaggagtga ctccttatta tttctttatc aatcgccccg ttgcaggtaa
     7681 ccgtgatttc gtccttcctc tatccgaggt ataccggatc gtagagcagg cgaaagcaag
     7741 aacgtccggt ctaggcaaaa gaattcgttt atccatgagt catacgtccg ggaagattga
     7801 gattttggcc atagagaacg ggaaggctta tctgaaatat catcaatccc gtgaggatca
     7861 atacggcaaa tttatgatta tggactgccc gaaggatgcg gcttggttcg atgatttgcc
     7921 aggaagtgaa caacattgga aacaaccgac gaaaaaatcg gattctataa tatctgcgaa
     7981 cgagcttcct gatatgccgc aaggcagaag cttgactctc agttgacgag aattatgcca
     8041 aaaaaggagg caccttcatt gagagggtgt ctactttgta gatttgtgcc tttccaaatg
     8101 aaaataattg cgctataata tagaaacata tgttcttaat gttgtaagtt gttttgagca
     8161 gggaggggga attaaggtca tgttcttgcg aagcgtacag attatgaagc agcaatttcc
     8221 gaataaatcg gcttatccgt tttcgatacc ggcgttaagg gaagtggaat cgatcgcatt
     8281 ccaaggcaat gtcaccttct tcgttggtga gaacggctcc ggcaaatcga ctattctgga
     8341 agctatcgcc tatcaatgcg gctttaatac tgctggagga ggacggaata acttctatga
     8401 ggtcgatgcc tccagttcct ctttaggtaa ttatgtacgg ctatcatgga tgcctaagat
     8461 tacgaacggt tttttcctgc gggcggaaac attctatcag ttcgccagcc atattgacga
     8521 aatgccggaa agcttgaggt attatggagg tcgctctttg catgcgcagt ctcatggtga
     8581 agcgtttcta tctttgtttc aacaccggtt tggcaaaaaa gccatctacc tgctcgatga
     8641 gccggaggcc gcgctgtcac ctgcccggca gcttgctctg ctgcgaataa tgaaggattt
     8701 ggaaaaggaa gcgcagttca tcgtagcaac gcattccccg attttactag gctatcccga
     8761 tgctcaaatt ttagattttg atcgttctcc tattaagtcc atccggtatg aagatacact
     8821 gcactatatt gttacccgac gattcttgga gaataagaag gcggttttgg cggaactgtt
     8881 tagcgaataa gccgaagagt cttcactaac attcctgttg taatagaatt cccaattgca
     8941 ggcagagttc atccatagga acacaaaaaa catacagcat ccattaaaat taaggttgaa
     9001 ataaccttgc tttcatgttg ctttaataat cctcctctat tataaaaagt gacccccctt
     9061 aatatagatg gctgcccaca gcatatggct gtgggcagca ctggttttaa aggctgaccg
     9121 gatcgtccgg ttggcttttt cattttatag agctcaacaa tccagtgaat agatgggctg
     9181 cgctttcgtt atagttacgg gattatccat ttgacgtgga atatactgcc aaaatgcttt
     9241 ttagaaaagg ttgaaaatag ttcaaccttt tgagagcggt tccagtcccc tataataaca
     9301 ttatctcaca tcgaaagatt agacaggagg taagcgtatt catgagaatc atctacttgg
     9361 acatcgattc gcttagaccg gatcatatgg gttgttacgg ctataatcga aatacaaccc
     9421 caaacattga taaaatcgcc tcagagggag taaggttcaa cagctgttat tgcgcatcgt
     9481 ctccctgtgt tccttccaga ggaagcttcg tatcgggacg ttttggcatt catcatggag
     9541 ccttaaccca ttggggaccg ggcggagagt tccaatatcc tgaaggagat gggcacagta
     9601 aagagattcc tttctttaca agatatttac gggaagcagg aatgaagacg gttacgttct
     9661 cttcctttgg agatcgtcat catgcatggt ggtattttgc tggctggaac gaagtgcata
     9721 ctcatacgtt gagagaaggc aatgagaatg ctgatgaagt gaatgcatcc gtcatccctt
     9781 ggctgaagca gcacggtaca gaagacaatt atttcttaca cattcagtat tgggacccgc
     9841 atacgttcta cacttaccct attgaatata tggaccagtg gaaagattca ccggttaagg
     9901 ctttccctga tgaggctacg atagcttcgc agcaggagca cagctttcct cgttcagcac
     9961 cattcctgca ctggggagac aagtacccgg cgacgatgcc tggtcaaatt tctaaccgca
    10021 gcgatttcaa acacgcgatt gatggctacg acggcggtat cagttatatg gataagcatg
    10081 tcggacatct gctcgacact cttcgtgagc taggcattga agacgaggta tgcttcatta
    10141 ttagtgccga tcatggcgaa tcgatgggag agcaaggtat ttacctcgag catgcaagcg
    10201 ctactgaggc ggtacatcat ctgccgcttg tcatcaaggt tcccggaatg cagaatcagg
    10261 gaacggcaat cgatggattc atctacaatg tcgatgtcat tgcaaccatt gccgacatgg
    10321 ttggactgga ggtgccgtcc ggctgggatg ggaaatcttt ccttcctgca ctgcaagggg
    10381 agca
//
