LOCUS       NZ_CP007145            20972 bp    DNA     circular CON 22-OCT-2024
DEFINITION  Hymenobacter swuensis DY53 chromosome, complete genome.
ACCESSION   NZ_CP007145
VERSION     NZ_CP007145.1
KEYWORDS    RefSeq.
SOURCE      Hymenobacter swuensis DY53
  ORGANISM  Hymenobacter swuensis DY53
            Bacteria; Bacteroidota; Cytophagia; Cytophagales; Hymenobacteraceae;
            Hymenobacter.
REFERENCE   1  (bases 1 to 4904241)
  AUTHORS   Jung,J.-H., Jeong,S.-W., Joe,M.-H., Cho,y.-j., Kim,M.-K. and
            Lim,S.-Y.
  TITLE     Complete genome sequence of ionizing-radiation resistance bacterium
            Hymenobacter swuensis DY53
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4904241)
  AUTHORS   Jung,J.-H., Jeong,S.-W., Joe,M.-H., Cho,y.-j., Kim,M.-K. and
            Lim,S.-Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-JAN-2014) Radiation Research Division for
            Biotechnology, Korea Atomic Energy Research Institute, 29 Geumgu
            street, Jeongeup 580-185, South Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: gsAssembler v. 2.6
            Genome Coverage                   :: 8.3x; 814x
            Sequencing Technology             :: 454; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000576555.1-RS_2024_10_22
            Annotation Date                   :: 10/22/2024 15:19:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,526
            CDSs (total)                      :: 4,471
            Genes (coding)                    :: 4,438
            CDSs (with protein)               :: 4,438
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 44
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 33
            CDSs (without protein)            :: 33
            Pseudo Genes (ambiguous residues) :: 0 of 33
            Pseudo Genes (frameshifted)       :: 7 of 33
            Pseudo Genes (incomplete)         :: 23 of 33
            Pseudo Genes (internal stop)      :: 9 of 33
            Pseudo Genes (multiple problems)  :: 5 of 33
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:59:19
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4822196
            Orig. end                         :: 4843168
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP007145.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The bacteria is available from Prof. Myung Kyum Kim in Seoul
            Women's University (mkkim@swu.ac.kr).
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20972
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..20972
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20972
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10972](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10972
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            1781..2437
                     /locus_tag="HSW_RS21890"
                     /old_locus_tag="Hsw_4239"
     CDS             1781..2437
                     /EC_number="3.4.23.36"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948756.1"
                     /locus_tag="HSW_RS21890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4239"
                     /product="lipoprotein signal peptidase"
                     /protein_id="WP_044003883.1"
                     /transl_table=11
                     /translation="MKYWKYYLVALLVIVIDQLSKWAVHRYMPLGMPGEIPLLGDWFKL
                     HYTLNPGMAFGVELPPPYGKILLTSFRLVAVTGIAYYIYKLWKQRAPQGFIVCVAMILG
                     GALGNVIDSIFYGILYNNAPYGSPTPWFHGQVIDMLYVDIYEGFLPSSWPLMGGSHVSL
                     WPIFNIADSAIFVGVALILLFQSRFFAHHEAAHPLAADDAQAAQTRRDAEASEVA"
     gene            complement(2536..3522)
                     /locus_tag="HSW_RS21895"
                     /old_locus_tag="Hsw_4240"
     CDS             complement(2536..3522)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020599821.1"
                     /locus_tag="HSW_RS21895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4240"
                     /product="aldo/keto reductase"
                     /protein_id="WP_044003884.1"
                     /transl_table=11
                     /translation="MQYRKLGKTGFNVSEISLGTWQVGGKWGDPFSHDTADAILNSAVD
                     SGINFIDTADVYGDGESEKAVGRLVRSRSERVYVATKCGRQLQPHTNEAYQPAALRRFV
                     ENSLRNMQLDTLDLIQLHCPPTEVFYRPEIFELFDRLQEEGKIRHLGVSVEKVEEGLKA
                     LTFPNVTTIQLIFNMFRQRPAELLFQEAKRHDVGLIVRVPLASGLLTGKFSPHTTFSPD
                     DHRQFNRDGAAFDKGETFSGVDYETGLAAVEELKKIFADQPSLAPLALRWVLMFDEVSC
                     VIPGASRPDQLQSNLQAAELPALTPEQMQAVKTVYEQRIKPLVHYSW"
     gene            3675..5723
                     /locus_tag="HSW_RS21900"
                     /old_locus_tag="Hsw_4241"
     CDS             3675..5723
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948755.1"
                     /locus_tag="HSW_RS21900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4241"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_044003885.1"
                     /transl_table=11
                     /translation="MSQPILSVRNLTIDFHSHRGNTRAVQDISFELRRGETLAIVGESG
                     SGKSVTSLALMGLIPLPPGQIVSGEARFYSDALGEVDLLQLSDKQLQKVRGNDIGMIFQ
                     EPMTSLNPVYTCGSQVVEALRLHTSLSEKEAAARTVELFTMAQLPRPEKIFTSYPHEIS
                     GGQKQRVMIAMAMACNPALLIADEPTTALDVTVQARMLRLIDDLRRQHNTAVIFITHDL
                     GVVAEIADRILVMYRGRVVEQGAVLDIFTNPQHPYTKGLLACRPKLSVGRKKLPVVADF
                     MRETADGGFVSTETEFVQVADGLVPGSVQAASQSDSETTKTFPVEHSVSRFGEPLFGVE
                     SAPGAESGQPLLFDAATPERLGANSELVGAATTGTEATPEYSVALGFNPETSASATPAT
                     NHEQQFTSNEPILRVENLNVHFPIRKGFFNRTKEFVRAVDGVSFDIYPGETVGLVGESG
                     CGKTTLGRALLRLVEPTSGSILFDGVNLAALPAEALRRKRREFQMVFQDPYAALNPMMT
                     VGEAILEPMRVHGVGGSRQEQKARVLELLRTVGLKDEHFQRYPHEFSGGQRQRICIARA
                     LALQPKCIICDESVSALDVSVQAQVLNLLNDLKREFGITYLFITHDLSVARFMSDRLLV
                     MRQGRIVESGLAADLYANPQHEYTKQLLAAIPKDTPADIRAAVASRA"
     misc_feature    5732..5745
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 19.94"
                     /tool="antismash"
     gene            5757..6500
                     /locus_tag="HSW_RS21905"
                     /old_locus_tag="Hsw_4242"
     CDS             5757..6500
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025602.5"
                     /locus_tag="HSW_RS21905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4242"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_155833103.1"
                     /transl_table=11
                     /translation="MRIIYPSLPYEVRVVDPMWEDEYRWARAHGWAVALYDSETQRLGP
                     DSSTPALYRGWMLSEGEYHSLERRTPLLVSVASYLSSHLATGWYEAVQNLTFSSWFLKA
                     NQPPDFSAGQRYFVKGLVKSFGEDSVVASVAQWQQLYRRHELLPEELLFVRQHAALLPD
                     SERRFFVVAGEAYGANGTMLPPSLQPAVEALQPRLFYSLDVVLTQAGTPVIVEVGDGQV
                     SDLKEWMLPDFGSTVLRALARVTQP"
     gene            6673..9216
                     /gene="rnr"
                     /locus_tag="HSW_RS21910"
                     /old_locus_tag="Hsw_4243"
     CDS             6673..9216
                     /EC_number="3.1.13.1"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004518 - nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rnr"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948754.1"
                     /locus_tag="HSW_RS21910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4243"
                     /product="ribonuclease R"
                     /protein_id="WP_044003887.1"
                     /transl_table=11
                     /translation="MKEKDEPAAPRASRAKAARGDKATTTTTEISQDLVFRIFRDNPGK
                     VLAYRQLSRRLGVTTKEQRDEIFAHLKNLKKSGLLTLVQNDEYRLTDDEAVLAAAPAPT
                     PKGRKRPAAAAEATVAQPAAQPADVEFGQDPLVHRRREAGFDFPGDNRRSGRRSGKPDF
                     TDTVVGTVDLASQKFAFVVSEDSEQDIRVFTDRLMFAMEGDTVRVRLRGSRDGKPVGDV
                     VEVIKRERAELVGRLQMQGSIGFVKPDNRKLYFDALVTPEHLGGARHGDKVLVRITEFP
                     ESDSGSLPSGEVIRNFGPAGQNEAEINAIMAEFGLPFEFPAEVEEESEAIPLEIPQAEI
                     ARRRDFRHITTFTIDPADAKDFDDALSIQQLENGHWEIGVHIADVTHYVRPDMALEKEA
                     RHRATSVYLVDRVIPMLPERLSNGLCSLRPNEDKLTFSAVFELDENGKLYSSWFGKTVI
                     HSDRRFAYEDAQERIEGLDSDYTAEVQLMNSIAKKLCAARFRQGAISFETQEVKFRLDE
                     NGKPLGVFVKERKDAHKMIEEFMLLANRKVAEFVFKLRNRKPRFTMVYRVHDAPDPERL
                     QTFALFAKKFGHQLDLTNPRTISTELNDLSTDVVGRPEQNVIQGLAIRTMAKATYTTDP
                     RGHFGLAFEHYSHFTSPIRRYPDMMAHRLLEHYLEGGGNVDVEPIEEECKHSSTREKLA
                     ASAERASIKFKQVEFLQDHIGSEFTGVISGLTEWGVYVEIPENKCEGMVRVSDIPGDFY
                     ELDKDNYRLVGQRTKRIIQFGDEMQIVVKAANLLDRTIDFELVDNRPDSVKSQDRDDRS
                     GRRGYRPERSSKGGRPDGGGKSGSGKSASGSKRRR"
     gene            complement(9359..9862)
                     /locus_tag="HSW_RS23275"
                     /old_locus_tag="Hsw_4244"
     CDS             complement(9359..9862)
                     /GO_function="GO:0015291 - secondary active transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR01352.1"
                     /locus_tag="HSW_RS23275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4244"
                     /product="TonB family protein"
                     /protein_id="WP_052346746.1"
                     /transl_table=11
                     /translation="MVTASRLLALGLLLLAAATACAQNSYNWWDARPPAPVTSPPRPAR
                     KPAPVAPSSAIVVVIDSLPLTTGKYTYVEVMPAFPGGTESMLNFLRKNLQRPRGPRQHG
                     RILVNLIVSTTGEVTEVQVAPVHGLSPAYDAAAVECVRRLPRFKPGHREGKPVATALTL
                     PVIF"
     gene            10001..10972
                     /locus_tag="HSW_RS21920"
                     /old_locus_tag="Hsw_4245"
     CDS             10001..10972
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948753.1"
                     /locus_tag="HSW_RS21920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4245"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_044005445.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.8e-61, bitscore:
                     204.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLSFFSQYLATGLAGISYGEQPANLYEPIRYIMGLGGKRIRPLL
                     TLLGAHLFTDDLAPVVKPALATEVFHNFTLLHDDLMDQAPLRRGQATVHEKWNPNVAIL
                     SGDVMLVRAYELFLDVPPHLLAHVLRRFSQTAAEVCEGQQWDMDFETETEVSIAQYLDM
                     IRLKTAVLLGFALELGALLGGASLADADHLRQFGVGIGLAFQLRDDLLDVYGDAATFGK
                     RVGGDIVSDKKTYLLLTAQAQAGAAQRATLARHIGQPVLDAEAKVQAVRAIYDELEIRP
                     QTEALINDYFLDALQHLERVTAPEMRKQPLHQLALQLLEREQ"
     gene            11070..11708
                     /locus_tag="HSW_RS21925"
                     /old_locus_tag="Hsw_4246"
     CDS             11070..11708
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948752.1"
                     /locus_tag="HSW_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4246"
                     /product="rhomboid family intramembrane serine protease"
                     /protein_id="WP_044003889.1"
                     /transl_table=11
                     /translation="MELTPTLVLTVLTAGISLYAWSKPELLDSWILDPYRVKRSNDWYR
                     FITSGFLHADFGHLLFNMIAFFSFGQTVEYIFLQLFGPTNGVLFFLLLYLGGIVVSDIP
                     TYLRHRDDPNYRSLGASGGVASVIFSAILFNPMGGIRIFPIPVDIPSFIFGFLYLAYSY
                     YMGRRRGDNINHDAHFYGALYGIILTFILLPRVGGFFWDQIRNSGMLNI"
     gene            11811..12089
                     /locus_tag="HSW_RS21930"
                     /old_locus_tag="Hsw_4247"
     CDS             11811..12089
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024788.5"
                     /locus_tag="HSW_RS21930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4247"
                     /product="PLD nuclease N-terminal domain-containing
                     protein"
                     /protein_id="WP_044003890.1"
                     /transl_table=11
                     /translation="MNKLIFLTNRIPAFALLLSVLTLPLLTACGSGRRSDGSLTIAGVF
                     YLILAVAAFLSLIKQDWSIGKKIVWGLIIWFFPFGGSIIYFLFSGRK"
     gene            complement(12166..12783)
                     /locus_tag="HSW_RS21935"
                     /old_locus_tag="Hsw_4248"
     CDS             complement(12166..12783)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HSW_RS21935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Hsw_4248"
                     /product="hypothetical protein"
                     /protein_id="WP_044003891.1"
                     /transl_table=11
                     /translation="MKKTILLVLLALAAGGYLYYRQLRTGPEYSLMQAYKAMTDHDVDT
                     FERYVDIGSVTGNLVDQVAEQGAALGGLNPGGLAMTGALQLFKPQLARTARAQVKRYVE
                     TGSAQAAAEAGSAGPLNVSVLGLAGKVVGEGSRFKGIKYTRKEGEQAFVGLELTQPRYD
                     TTLVLEVSMRNQGDYWQATAISNSGEIIRQIARWEKQRLIGK"
     gene            12915..13757
                     /locus_tag="HSW_RS21940"
                     /old_locus_tag="Hsw_4249"
     CDS             12915..13757
                     /GO_function="GO:0008081 - phosphoric diester hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948749.1"
                     /locus_tag="HSW_RS21940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4249"
                     /product="glycerophosphodiester phosphodiesterase family
                     protein"
                     /protein_id="WP_044003892.1"
                     /transl_table=11
                     /translation="MHTILPYPQIHGHRGCRGLLPENTLPAFRRAVEIGVEVIELDVVI
                     SADEQVVVSHEPWMSATICRQPDGRPILPAEQTRHNLYSLSYADIRAYDCGLTQHPGFP
                     SQQPQPAAKPLLREVVSELDKLAWTLGRPAVRYSVEIKSSPAYEPGFQPPPARFLELVL
                     AELQTTGILGRTTLLCFDTRVLRLAYEQLPEMPLCLLVEDTRPLHMHLAELGFQPHIYG
                     PDFRLLTPELAASLRTLGIGLVPWTVNEPADLRRMLQLHPTGITTDYPDRLMALRSAV"
     gene            13993..14445
                     /locus_tag="HSW_RS21945"
                     /old_locus_tag="Hsw_4250"
     CDS             13993..14445
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014814.5"
                     /locus_tag="HSW_RS21945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4250"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_155833104.1"
                     /transl_table=11
                     /translation="MKQIVHIYISSDYYTFPPMSHQGEILQEVIKNSGISITRIVDELG
                     ITRPTIYRKFKDETLDYNFVKRIGEIIGHDFSQDFTSLHQVVLPFSVTPVSHGVSVMSD
                     KGVTHKSTVTPMIESDSLKQLMQLQQKYIALLEAYNELLLKVYGPK"
     gene            14824..15387
                     /locus_tag="HSW_RS21950"
                     /old_locus_tag="Hsw_4251"
     CDS             14824..15387
                     /EC_number="3.1.2.20"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018476397.1"
                     /locus_tag="HSW_RS21950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4251"
                     /product="acyl-CoA thioesterase"
                     /protein_id="WP_044003897.1"
                     /transl_table=11
                     /translation="MSADHLPAYRPVSHSRVTLTELMIPSYANFGGKIHGGILLSLMDK
                     VAYAAASKHAGTYCVTVSVDGVNFLQPVEVGELVSLLASVNYVGRTSLLVGIKVIAEDV
                     RSGSVKHTNTCYFTMVAKDDEGRPSQVPGLLLETPDDTRRFLEAIKRREFKEQYRQEFD
                     NARSILALEEQQHLLEKERCQLGY"
     gene            complement(15700..16023)
                     /locus_tag="HSW_RS21955"
                     /old_locus_tag="Hsw_4252"
     CDS             complement(15700..16023)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017103.5"
                     /locus_tag="HSW_RS21955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4252"
                     /product="DUF721 domain-containing protein"
                     /protein_id="WP_052346747.1"
                     /transl_table=11
                     /translation="MALKKPHSSENSRQSDIVPLRDGIKALLRVYRLQGKLNEVTVVAS
                     WEKVMGKAVAMKTQQVYVSNNKLFVRLSSAPLKHELFMAKTRVLENLNAEVGEDIIKEV
                     VFL"
     misc_feature    complement(15990..16004)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.16"
                     /tool="antismash"
     gene            complement(16088..17200)
                     /gene="recF"
                     /locus_tag="HSW_RS21960"
                     /old_locus_tag="Hsw_4253"
     CDS             complement(16088..17200)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /codon_start=1
                     /gene="recF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018476400.1"
                     /locus_tag="HSW_RS21960"
                     /note="All proteins in this family for which functions are
                     known are DNA-binding proteins that assist the
                     filamentation of RecA onto DNA for the initiation of
                     recombination or recombinational repair; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /old_locus_tag="Hsw_4253"
                     /product="DNA replication/repair protein RecF"
                     /protein_id="WP_044003899.1"
                     /transl_table=11
                     /translation="MNLESLHLLFFKNYEEANLSFSAHINCFVGDNGSGKTNLLDAIHY
                     LSLTKSAFTVSDAQSIKQGEELFVVRGRFRPAPDEKPETIQCSLRQGQKKTVTHDKQAY
                     ERVSDHIGRYPVVLISPYDTDLIRQGSEERRKYFDSLLSQLDHTYLEQLIRYTHLLKQR
                     NSLLKLAADRQAGYDRDYLLVLDEQLAPVGEQLVQRRQEFLTEFEPIFQRHYEQLADAR
                     EVVTLTYKSELPGADFLKLLRLNERKDLTLQRTTTGPHRDDFTFLMDELPVKGYGSQGQ
                     QKSFAIALKLAQFEILAAHKQQKPLLLLDDIFDRLDEKRITRLMQLVANHTFGQIFLTD
                     THLERTDRVLADLSEDIRRFRVELGSVQPL"
     gene            17269..18447
                     /gene="pdhA"
                     /locus_tag="HSW_RS21965"
                     /old_locus_tag="Hsw_4254"
     CDS             17269..18447
                     /EC_number="1.2.4.1"
                     /GO_component="GO:0045254 - pyruvate dehydrogenase complex
                     [Evidence IEA]"
                     /GO_function="GO:0004739 - pyruvate dehydrogenase
                     (acetyl-transferring) activity [Evidence IEA]"
                     /GO_process="GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /gene="pdhA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948744.1"
                     /locus_tag="HSW_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4254"
                     /product="pyruvate dehydrogenase (acetyl-transferring) E1
                     component subunit alpha"
                     /protein_id="WP_081768560.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.5e-08, bitscore:
                     31.3, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="DXP_synthase_N (E-value: 5.1e-06,
                     bitscore: 23.8, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAETKVKAAPKASNSTKKSSAPKAAPKGKAAATKTAKQPDPVLPP
                     STEEGKAATGTPKATSPAQPEFSKETYLTWYEQMQLMRKFEEKAGQLYGQQKIKGFCHL
                     YIGQEACVAGAVSALTKDDKWITAYRDHAHPLALGTSPNAIMAELYAKATGCSKGKGGS
                     MHMFDKEVNFIGGHGIVGAQVPMGAGIGFAEKYNKTGNLCICYMGDGAVRQGALHEAFN
                     MAMLWKLPVIFVVENNGYAMGTSVQRTSNVTELHHIGRGYDMPSEPVNAMNVEDVHNAV
                     ARAAERARAGEGPTFLEFKTYRYKGHSMSDPAKYRTKEELEDYRSRDAIEAVRHTILTH
                     NMATEEDLAAIDEKIKGQVAESVEFAENSPFPTADELYKDVYVQQDYPYIRD"
     gene            18502..19278
                     /locus_tag="HSW_RS21970"
                     /old_locus_tag="Hsw_4255"
     CDS             18502..19278
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948743.1"
                     /locus_tag="HSW_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4255"
                     /product="tol-pal system YbgF family protein"
                     /protein_id="WP_081768561.1"
                     /transl_table=11
                     /translation="MSKIPFTGKSQQARQQQQRVVSPDPTQPLEAYNPEHPLLEDPDAL
                     AIRLVESEDFVRRNKNVLLGLLAVVVLAVAGGFGYYLWRGSQDTKGQAALFQAVSYWEA
                     DSLQKAMKGDGRNLGLERVASEYSGTDAGNLANFYAGVAALKEGKNKEAIDYLEDFSSD
                     DYLVQARAYSLLGDAHLEMNQAKEAADFYNKAANYNANEFFSPGYLLKEATAREAAKDY
                     EGAITAYNKILTDYASAAEATEAKEYKARAEALAGK"
     gene            19431..19907
                     /gene="ribH"
                     /locus_tag="HSW_RS21975"
                     /old_locus_tag="Hsw_4256"
     CDS             19431..19907
                     /EC_number="2.5.1.78"
                     /GO_component="GO:0009349 - riboflavin synthase complex
                     [Evidence IEA]"
                     /GO_function="GO:0000906 - 6,7-dimethyl-8-ribityllumazine
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="ribH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010609755.1"
                     /locus_tag="HSW_RS21975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4256"
                     /product="6,7-dimethyl-8-ribityllumazine synthase"
                     /protein_id="WP_044003901.1"
                     /transl_table=11
                     /translation="MATSLKNLSDYTSDHFVDISEKRFGLVVAEWNREITDTLAQGAFD
                     TLLKHGAKPENIFRNTVPGSFELTLGAQLLAQHEEIDAVICLGVVIQGETKHDDYICHA
                     VASGITNVSLKFNKPVIFGLVTTNTLEQAWDRAGGKHGNKGVEGAVAAIHMLGF"
     gene            20180..20563
                     /locus_tag="HSW_RS21980"
                     /old_locus_tag="Hsw_4257"
     CDS             20180..20563
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019948741.1"
                     /locus_tag="HSW_RS21980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Hsw_4257"
                     /product="TraR/DksA C4-type zinc finger protein"
                     /protein_id="WP_044003902.1"
                     /transl_table=11
                     /translation="MSEAPLRYSREELAEFEQIIQDKVTAARKEVAFIKETLSRKNDTG
                     TDNTASSSKVLEDGADTAEKESLNQLASRQMKFIQQLENALIRIKNGTYGVCIGTGKLI
                     PKERLRAVPHTQHSIEAKMARRD"
ORIGIN
        1 aaggcgtgga ccagacccgc ggctggttct tcaccctgca cgcgctggcc gtgatgctgg
       61 aagactcggt ggcctacaaa aacgtgatgg ccaacggctt ggtattggac aagaacggta
      121 acaagatgag caagcgcctc ggcaacgccg tggacccgtt tgccaccatc cagcagttcg
      181 gccccgacgc cacgcgctgg tacatgattg ccaacgccca gccctgggac aacctcaagt
      241 tcgacgtggc cggtatcacg gaggtgcagc gccgcttctt tggcacgctc ttcaacacct
      301 actcgttcta cgccctctac gccaacctcg acggcttcca ggcccgggag tttgaccgca
      361 cgccgcacgc cgagctaagc gagctggacc gctggattct gagcaagctc cagtcgctga
      421 ttctggaagt gcgcggccac tacgatagct acgaccccac gaaggccgcc cgcgccatcc
      481 aggatttcgt gaccgaccag ctctccaact ggcacgtgcg cctctcgcgc cgccgcttct
      541 ggaagggcga gctgaccgcc gacaagcgcg ccgcctacga aaccctgcag gaatgcctgg
      601 tggtagtgtc gcagctcatg gccccgattg cgcccttctt cgccgagtgg ctctaccaaa
      661 acatgaccaa cggcatgcgc gccgaagcca tcgagcgcaa caccccgctg gccgccgaat
      721 cggtgcacct gactttgctg gtggaggccg acgaagcccg catcgacaag gcgctggagg
      781 agcggatgga gctggctcag cgcatttctt cgctcacgca ctcgctccgc aagaagtcgg
      841 tgctgaaggt gcggcagccg ctgcagcgca tcctggtgcc ggtattcaac gattccaccc
      901 gcgcccaggt ggccttggtg gaagatctga tctgcgccga ggtgaacgtg aagcacgtag
      961 agttcctcga tgatgccagc ggcgtgctgg tgaagtcggt gaagcccaac ttcaagcgcc
     1021 taggccagca gtacggcgcc aagctgaaag ccgtgggtgc ccgcatccag cagatgagcg
     1081 ccgaggaaat cagcaccctc gaaaaaaccg gtcagctggc cgtggaaatc gacggcgaag
     1141 cctacaccct ggcccccgat gacgtggaaa tccgcaccca agacctgccc ggctggctgg
     1201 tggccaccga tggccccctc accgtggccc ttgacgtgac cctgaccgac gagttgcgcc
     1261 aggaaggcgt ggcccgcgag ctggtgaacc gcctccagaa cctgcgcaaa gacagcggcc
     1321 tggaagtgca ggacaaaatc cgggtgacgc tgcagcagca gcccgagctg gaagccgccg
     1381 tgcagtcgtt cggcggttac atccgtgagg aagtgcaggc cctgagcctg gatttcgccc
     1441 cggaaatcag cggcggcgcg gtgctggaat tcgatgagtt ttccgtgccg gtgctgctga
     1501 acgtagcaac tgcctaagcc tcaggagcca accgccgcct taaaaacggc ggttggcaca
     1561 tcggcgcaca aagaacagag ccggccctca aatccggctc aaaacggcat aaatcgccaa
     1621 ccgaaacata taccaacggc gcaacagttc ggctctcgcc tctgaggccg aagtccaaaa
     1681 atcttcgtca ctttgtgcta cgagagggga gaggttgcca gcctgacaat gtgtcgggat
     1741 ggagtctcac ttctcacttc taacctctca cctctataga atgaagtact ggaaatacta
     1801 cctagtggcc ctgttggtca tcgtcattga tcaactctcg aagtgggctg tgcaccgcta
     1861 catgcccctc ggcatgcccg gtgaaattcc gctgcttggc gactggttta agctgcacta
     1921 cacgctcaac ccgggtatgg ctttcggggt agaattgccg ccaccctacg gtaaaatcct
     1981 gctcaccagc ttccggctgg tggccgtgac gggcattgca tactacatct acaaattgtg
     2041 gaaacagcgt gccccgcagg gctttattgt gtgtgtagcc atgattctgg gcggggcgct
     2101 gggtaacgtt atcgactcga ttttctatgg tattctctac aacaatgcgc cgtatggttc
     2161 gcctacaccc tggtttcatg ggcaagtgat tgatatgctg tacgtggata tctatgaggg
     2221 tttcttgcca tcttcgtggc ctttaatggg aggctcgcac gtatcactat ggcccatctt
     2281 caacattgcc gattcggcta tttttgtcgg agtagccctg attctattgt tccagagccg
     2341 cttttttgcc caccacgaag ccgcgcaccc cctggccgcc gatgatgccc aagccgccca
     2401 gacccgccgc gacgctgaag cctcggaagt agcgtagaat aaactcacta agagccaaaa
     2461 ggcccgctgg aactgttcca gcgggccttt ttttggtttt tagaacttca tgctgagcag
     2521 cttctgcctt aaatcctacc agctatagtg caccagcggc ttgatgcgct gctcgtatac
     2581 cgttttcacg gcctgcatct gttccggtgt gagggccggc aactcggcgg cttgcaggtt
     2641 cgattgcaac tgatcgggcc gggatgcgcc ggggattacg cagcttactt catcgaacat
     2701 cagcacccag cgcagggcca gcggggccag gctgggctgg tcggcgaata tctttttcag
     2761 ctcctctacg gctgccaggc ctgtttcata gtccacgccc gagaaagttt cgcccttgtc
     2821 gaaggcggcc ccgtcgcggt tgaactggcg gtggtcatcg ggggagaagg tggtgtgggg
     2881 cgagaatttg ccggtgagca ggccgctggc cagcggtacg cgcacaatca gacccacgtc
     2941 gtggcgcttt gcctcctgaa acagcagttc ggccggccgc tgccggaaca tgttgaaaat
     3001 gagttggatg gtcgtaacgt tggggaaggt cagggccttg aggccttcct ccaccttctc
     3061 cacgctcacg cccaggtgcc ggattttgcc ttcttcctgc agccggtcga atagctcgaa
     3121 gatttcgggc cggtagaaca cctccgtggg cgggcagtgc agctgaatca ggtccagcgt
     3181 atccaactgc atgttgcgca ggctgttttc cacgaaccgg cgcaaagcag cgggctgata
     3241 agcctcgttg gtgtggggct ggagctggcg gccgcacttg gtggcaacgt acacccgctc
     3301 agagcggctg cgcacgagtc gacctaccgc cttttcactt tcgccgtcgc cgtacacgtc
     3361 ggccgtgtca atgaagttga tgcccgaatc gacggcgctg ttgaggatgg cgtcggcggt
     3421 gtcgtggctg aacgggtcgc cccatttgcc gcctacctgc caggtgccga ggctgatttc
     3481 tgaaacgttg aagccggttt taccgagttt gcggtactgc atgtggttag gaaatagatg
     3541 tacgatggtt tttcggagcc tacggaataa taattcgtaa cccaaacgaa caaccggtgc
     3601 ttacgcgaaa cgtcccgggc aagctaccgc gcatcggcct atctttactt ttttccgtct
     3661 cgtttttcgt tgccgtgtcc cagcccatcc tctccgttcg caacctcacc atcgattttc
     3721 actcgcaccg gggcaacacg cgggccgtgc aggatatttc ctttgagctg cgccggggcg
     3781 aaacgctggc catcgtgggc gaatcgggct cgggcaagtc ggttacctca ctggccctga
     3841 tggggctgat tccgctgccg cccggccaga ttgtgagtgg agaagcgcgc ttttacagcg
     3901 acgcattggg ggaggtggat ctgctgcagc tttccgacaa gcagttgcag aaagtgcgtg
     3961 gcaacgacat cggaatgatt tttcaggagc cgatgacctc gctgaacccg gtgtacacct
     4021 gcgggagcca ggtggtggaa gctctgcggc tgcacaccag tctctcggaa aaagaagctg
     4081 ccgctcgcac cgtggagcta ttcacgatgg cccaactgcc gcgccccgag aaaatattca
     4141 cgagctaccc gcacgaaatc agcggcggcc agaagcagcg cgtgatgatt gccatggcta
     4201 tggcctgcaa ccccgccctg ctcatcgccg acgaacccac caccgccctc gacgtgacgg
     4261 tacaggcccg catgctgcgc ctgatcgacg acctgcgccg tcagcacaac accgccgtca
     4321 tcttcatcac ccacgatttg ggcgtggtag ccgaaatagc tgaccggatt ctggtgatgt
     4381 ataggggccg ggtagtggag cagggcgcgg tgctcgatat tttcaccaat ccgcagcatc
     4441 cgtacacgaa aggcctgctg gcttgccggc caaaactttc cgtcggccga aaaaaacttc
     4501 ccgtagtggc cgatttcatg cgtgaaacgg ccgatggtgg ctttgtcagc accgaaactg
     4561 aatttgttca agtggctgat ggtcttgtac ctggatctgt gcaagctgcc tctcaaagcg
     4621 acagtgaaac taccaaaacg tttcccgtgg aacattctgt ttcacgcttt ggtgagccgc
     4681 ttttcggtgt agaatcggct ccgggcgcgg aatcagggca gccgctgctg tttgacgcgg
     4741 ccacgccgga acgcctgggg gcaaactctg agctcgtcgg cgcggcaaca acgggtacgg
     4801 aagccacccc agagtattcc gtagccctgg gtttcaaccc tgaaacctcc gcgtcagcta
     4861 caccagcaac gaaccacgaa caacagttca cgagcaacga gcccattctg cgcgtggaga
     4921 acctgaacgt gcactttccg atccggaagg gcttcttcaa ccgcaccaaa gaatttgtgc
     4981 gggccgtgga tggggtaagc ttcgatattt accccggcga gacggtaggg ctggtggggg
     5041 agtcgggctg cggcaaaacg accctgggcc gggcgctgct gcggctggtg gagcccacgt
     5101 cgggcagcat cctgttcgac ggtgtgaatc tggccgcgtt gcctgccgag gcactgcgac
     5161 ggaagcggcg ggagtttcaa atggtgttcc aggatccgta cgctgccctc aacccgatga
     5221 tgaccgtagg cgaggccatt ctggaaccca tgcgcgtgca cggtgtgggc ggcagccggc
     5281 aggagcaaaa ggcccgggtg ctggaactgc tgcgcacggt gggcctcaag gacgagcact
     5341 tccagcgcta cccccacgag ttcagcggcg gtcagcgcca gcgcatctgc attgcccgcg
     5401 ccctagcgct gcagcccaag tgcatcatct gcgacgaatc cgtatcggcc ctcgacgtat
     5461 cggtgcaggc gcaggtgctc aacctgctca acgacctcaa gcgcgagttc ggcatcacct
     5521 acctcttcat cacccacgac ctgtcggtgg cccgcttcat gagcgaccgg ctgctggtga
     5581 tgcgccaggg tcggatcgtg gaaagcggcc tcgccgccga cctctacgcc aacccccagc
     5641 acgagtacac gaagcagctg ctggccgcca ttcctaaaga cactcccgcc gacattcgcg
     5701 ccgccgtggc cagccgggcg taagttcgtc tttgacttat tataaactgc gacggtatgc
     5761 gcatcatcta tccttctctg ccctacgaag tccgcgttgt ggatcctatg tgggaagacg
     5821 aataccgatg ggcgcgggcg cacggttggg ctgtggccct gtatgacagc gaaacgcaac
     5881 gcttggggcc tgatagttca actccggctc tttaccgggg ctggatgctt tccgaggggg
     5941 aatatcacag cctggagcgc cgtacgccct tgctggtttc cgtagccagt tatttgtctt
     6001 cgcacctggc tacggggtgg tacgaggctg ttcagaacct cacattttcc agttggttcc
     6061 tgaaggcaaa ccaaccgccc gacttttcag ctgggcagcg ttacttcgtg aaaggtctgg
     6121 tgaagtcgtt tggcgaagat tccgtggtgg cttcggtagc acaatggcaa cagctttatc
     6181 ggcggcatga actattgccg gaagagttgc tgttcgttcg gcagcatgca gcattgttgc
     6241 ccgactctga gcgacgcttc tttgtagtag ctggcgaggc ctatggtgct aatggcacta
     6301 tgttgccccc atccttgcag cctgcagtag aggccttaca gccacgtctg ttttatagtt
     6361 tggatgtagt actcacccaa gctggcactc cggtgatagt ggaagtaggg gacgggcagg
     6421 tatctgatct gaaggaatgg atgctgcccg attttggctc taccgtactg cgtgccctgg
     6481 cccgcgtaac ccaaccgtaa tccgctattt tcagtcggct atagttattg ctcgctatat
     6541 ttcgtatcat ctctccaaag cccgtagaac ggctgctatt taccatttcg gaagccgggc
     6601 acaatcctct gcttccttct accaaccact gccgcctgcg aaaacgacaa cttctggcgg
     6661 ctccttttct acatgaaaga aaaagacgaa cccgccgccc cccgcgcctc ccgcgcgaag
     6721 gcagcccgtg gcgataaagc cactacaact accaccgaaa tcagccagga cctggtgttt
     6781 cgcatcttcc gcgacaaccc cggcaaggtg ctggcctacc gccaactttc ccgccgcctg
     6841 ggcgtgacca ccaaagagca gcgcgacgag attttcgcgc acctcaaaaa ccttaagaaa
     6901 agcggcctgc tcacgctcgt gcagaacgac gagtaccgcc tcaccgacga cgaagccgtg
     6961 ctggccgccg cgcctgcgcc gacgcccaag ggccgtaagc gtccggctgc tgctgccgag
     7021 gctaccgttg ctcaaccggc tgcccagccc gccgacgtgg agtttggcca agacccgctg
     7081 gtgcaccgcc gccgtgaggc cggcttcgac ttccccggcg acaaccgccg ctcgggccgc
     7141 cgcagcggca agcccgactt taccgacacc gtagtgggca ccgtggacct ggcctcgcag
     7201 aagtttgcct tcgtggtgag cgaggacagc gagcaggaca tccgggtgtt cactgaccgc
     7261 ctcatgtttg ccatggaagg cgacacggtg cgggtgcggc tgcgcggctc ccgcgacggc
     7321 aagcctgtgg gcgacgtagt ggaagtcatt aagcgggagc gggccgaact ggtgggccgc
     7381 ctgcagatgc agggctccat cggcttcgtg aagcccgata accgcaagct ttacttcgat
     7441 gcgctggtga cgcccgagca cttgggcggg gcccgtcacg gcgacaaggt actggtgcgc
     7501 atcacggagt ttccggagag tgactcgggt agcctgccct cgggtgaggt gattcgcaac
     7561 ttcgggccgg ctggtcagaa cgaggcggag attaacgcca tcatggccga gttcgggctg
     7621 ccgtttgaat tcccggccga ggtagaggag gagtcggaag ccattccgtt ggaaatcccg
     7681 caggccgaga ttgcgcgccg ccgcgacttc cgccacatca ccaccttcac catcgacccc
     7741 gccgacgcca aggacttcga cgatgccctc agcatccagc agctcgaaaa cgggcactgg
     7801 gaaattgggg ttcacattgc cgacgtgacg cattacgtgc ggcccgatat ggccctggaa
     7861 aaggaagccc ggcaccgcgc tacctccgtg tacctcgtgg accgcgtgat tcccatgctg
     7921 cccgagcgcc tcagcaacgg cctctgttcc ctgcgtccca acgaggacaa gcttaccttc
     7981 tcggccgtgt ttgagctgga tgagaacggc aagctctata gctcctggtt cggcaaaacc
     8041 gtcattcact ccgaccgtcg cttcgcctac gaagatgctc aggagcgcat cgaaggtctg
     8101 gactccgact acacggcgga ggtgcagctg atgaacagca ttgccaagaa gctgtgcgcc
     8161 gcccgcttcc ggcagggggc catcagcttc gaaacccagg aggtgaagtt ccggctggat
     8221 gaaaacggca agccgctggg cgtgttcgtg aaggagcgca aggatgctca caagatgatt
     8281 gaggagttca tgctactggc caaccgcaag gtggccgagt tcgtgttcaa gctccgcaac
     8341 cgcaagcccc gcttcacgat ggtgtaccgc gtgcacgatg cgcccgaccc cgagcggctg
     8401 cagaccttcg cgctgttcgc caagaaattc ggccaccagc tcgacctcac caacccgcgc
     8461 accatcagca ccgagctcaa cgatttgagc accgacgtgg tgggccggcc cgagcagaac
     8521 gtgattcagg gactagccat ccgcacgatg gcgaaggcca cctacaccac cgacccccgc
     8581 ggccacttcg gcctagcctt cgagcactac tcgcacttca cctcacccat ccgtcgctac
     8641 cccgatatga tggcgcaccg cctgctggag cactacctgg aaggcggcgg caacgtggac
     8701 gtggagccta tcgaggaaga gtgtaagcac tcctcaacgc gggagaaact ggctgccagc
     8761 gccgaacggg ccagcatcaa gttcaagcag gtggagttcc tgcaggacca tatcggctcg
     8821 gagtttacag gcgtcatctc gggcctgacc gagtggggcg tgtatgtgga gattccggaa
     8881 aacaagtgcg aaggcatggt gcgcgtgagc gacatcccgg gcgacttcta cgagctggac
     8941 aaggacaact accgcctcgt gggtcagcgc accaagcgca tcatccagtt cggtgacgag
     9001 atgcagattg tcgtgaaagc ggccaatcta ctcgaccgga ccatcgactt cgagctggtg
     9061 gataaccgcc ccgactcggt gaaaagccag gaccgcgacg accggagcgg ccgccggggc
     9121 taccgccccg agcggagcag caaaggcggc cgccccgatg gtggcggcaa gtccggcagt
     9181 ggcaagtcgg ccagtggcag taagcgccgc cgctaagctg ccgtcattgt gagggccaag
     9241 gacactgcgc gcagcaagcg gcatcaatcc ggccttcatc agaacgacaa atggtaacct
     9301 attcaaaagc tcctggcatc tgttgatgtc aggggctttt tgctggggtg gtgttacttc
     9361 agaaaattac cggaagggta agggccgtgg ctaccggctt gccctcacgg tggcctggtt
     9421 tgaaccgggg cagccggcgc acgcactcca cggccgccgc atcgtaggcc ggggagagac
     9481 catgcaccgg tgctacctgc acctcagtaa cctcacccgt agtggacact atcaggttca
     9541 ctagtatccg cccgtgctgc cgcggcccgc gggggcgctg caggtttttg cggagaaagt
     9601 tcagcatgct ctccgtccca cctgggaagg ctggcatcac ctccacgtac gtgtacttgc
     9661 ctgtggtaag cggtagcgag tcgatgacta ctacaatagc ggaggaagga gcaacgggag
     9721 ccggcttgcg ggccggccgg ggcggggacg ttaccggcgc gggtgggcgg gcatcccacc
     9781 agttgtagga gttctgggcg caagccgtgg cagctgccag cagcagtaat ccgagggcca
     9841 agaggcggga ggcagtaacc atagcggggc gacaattgtc tggttgctga acgcgggaag
     9901 cgggcccaaa agtacgctgc ccggcggtgg tccgttgttg attccgcacc ttctcccaac
     9961 ccgccgtacc ttgccaacct caaccttgac cccgcccttc gtggaccttt ccttctttag
    10021 ccagtacctt gctaccggcc tcgccggcat ttcctacggc gagcagcctg ccaacctgta
    10081 tgaacccatc cgctacatta tggggctggg cggcaagcgc atccgacccc ttcttactct
    10141 gctcggtgcc cacctgttca ccgacgacct cgcgcccgta gtgaagcccg cgctggccac
    10201 tgaggtcttc cacaacttca ccctgcttca cgatgacctg atggaccaag ctcctttgcg
    10261 ccggggccaa gccaccgtgc atgagaagtg gaaccccaac gtggccatcc tgagcggcga
    10321 cgtgatgctg gtgcgggcct acgagctgtt cctggacgtg cccccgcacc tgctggccca
    10381 tgtgctgcgc cgcttctcgc agaccgccgc cgaggtgtgc gaaggccagc agtgggacat
    10441 ggattttgaa accgaaaccg aggtcagcat tgcgcagtac ctggatatga tccggctgaa
    10501 gacggccgtg ctgctgggct ttgcgctgga gttgggcgcc ctgctgggcg gtgcttccct
    10561 agccgatgcc gaccacctgc gccagttcgg ggtgggcatc gggctggcct tccagctgcg
    10621 cgacgacctg ctggacgtgt atggcgacgc ggccaccttt ggcaagcggg tagggggcga
    10681 catcgtgagc gacaagaaaa cctacctgct gctcaccgct caggcccagg ctggcgctgc
    10741 ccagcgcgct acgcttgccc gccacatcgg ccagcccgtg ctggatgccg aagccaaggt
    10801 gcaggcagtg cgcgccatct acgacgagct cgaaattcgc ccccagacgg aagctctcat
    10861 caacgactac ttcttggatg ccttgcagca cttagagcgc gtgacggccc ccgaaatgcg
    10921 caagcagccc ctgcaccaac tggccctgca gctgctggaa cgcgaacagt agcgcgcgtg
    10981 tcattccgac gcaggaagaa tgacacgcgc gctgtcctga atgattatcg gacggctatt
    11041 tttctctctc ctctacatct tcttttctca tggaattaac tcccacgctg gtgctgacgg
    11101 tacttaccgc cggcatctcc ctatacgctt ggtcgaaacc cgagctgctg gatagctgga
    11161 ttctggaccc ctaccgcgtg aagcgcagca acgactggta ccgcttcatc acctcgggct
    11221 ttttgcacgc cgatttcggg cacctgctgt tcaatatgat tgccttcttc tcctttgggc
    11281 agacggtgga gtatatcttt ctgcagctgt tcgggcccac caacggggtg ttgtttttcc
    11341 tgttgctgta tctgggtggc attgtggtgt cggacattcc cacctacctg cgccaccgcg
    11401 acgaccccaa ctaccgcagc ctcggggctt cgggtggagt ggcctcagtt atcttttcag
    11461 ccatcctgtt taaccccatg ggtggcatcc gcatcttccc cattccggtt gacattccca
    11521 gcttcatctt cggcttcctg tacctggctt actcctacta catgggccgc cgtcggggcg
    11581 acaacatcaa ccacgatgcg cacttctacg gagcgctgta tggtatcatc ctgacattca
    11641 ttctgttacc gagagttggt ggcttcttct gggaccaaat ccgcaattct ggaatgttaa
    11701 atatttgatt ttcaatgcat tgtgatttag ataggttgag ccatatatct atttcgtagc
    11761 gggagcgtaa acgcaggcag aatactctcc aaccaatcac ctccctgcac atgaataagc
    11821 tcatcttcct caccaaccgc attccggctt ttgcgctgtt gctctcagtt cttacgctgc
    11881 ctttgctgac ggcctgcggc agtggccgcc gctcggatgg ttctcttacc attgccggtg
    11941 ttttctacct cattctcgct gttgctgcct tcctgagtct gatcaagcag gattggtcta
    12001 ttggcaagaa aatcgtctgg ggtctgatca tttggttctt ccccttcggt ggttctatta
    12061 tttacttcct gttttccgga cgtaagtaac caatccgatc caagtgcaaa aaagccccgg
    12121 taccaatatg gtgccggggc tttttcgtag atagtagaga agtccctact taccgatgag
    12181 tcgttgtttt tcccagcggg caatctgccg gatgatttcc ccgctgttgc tgatggccgt
    12241 ggcctgccag tagtcgccct ggttgcgcat gctcacttcc agcaccagcg tcgtatcgta
    12301 gcggggctgc gtgagttcta ggcctacgaa agcctgctcg ccctccttgc gggtgtactt
    12361 aatgcccttg aaccggctgc cttcgcccac tactttcccg gccagaccca gcaccgaaac
    12421 gttcaacggt ccagccgaac cagcctcagc agctgcctgc gccgagccgg tttccacgta
    12481 gcgtttcacc tgagcccgcg ccgtgcgggc cagctgtggc ttgaacagct gtagggctcc
    12541 cgtcatggcc agtccgcccg ggttcaggcc acccagggcc gcgccctgct ccgccacctg
    12601 atccaccagg ttgccggtga cgctaccaat atccacgtac cgctcgaagg tgtccacgtc
    12661 gtggtcggtc atggctttgt aggcctgcat cagggaatac tcggggccag tccggagctg
    12721 ccgatagtag aggtagccgc ctgcggccag ggccagcagc actagcagaa tcgtcttttt
    12781 catgggggga gagttgggaa atgaaagggg aattaggagg ttgttgccaa gcctgaatgc
    12841 gtggttccgc tgcattccgg ccctcggttt ctggtatggg tatctgtacg aagccaacgg
    12901 ccgtagggct tagcatgcat acaatacttc cctatccgca aatacacggg caccgcggct
    12961 gccgcggact gctccccgaa aataccttgc cggctttccg ccgggccgtt gaaatagggg
    13021 tggaagtgat agaactggac gtggtcattt ccgccgatga gcaggtggtc gtatctcatg
    13081 agccgtggat gtcggccact atctgccgcc agcccgatgg tcgtcctatc ctgcccgctg
    13141 agcagacccg gcacaacctc tacagcctgt cgtacgctga tatccgcgcg tatgattgcg
    13201 gccttaccca acaccccggt ttcccctcgc agcagccgca acccgcggcc aaaccactac
    13261 tgcgggaggt agtgtcggag ctggataaac tggcttggac actaggccgt ccggcggtgc
    13321 gctacagtgt ggaaatcaaa agcagccctg cctatgagcc cggcttccaa ccgccgccgg
    13381 cccggttcct ggagctcgtg ttagccgaac ttcagaccac tggaattttg ggccgaacca
    13441 cgctgctctg ctttgatacc cgggtcctcc ggctggccta tgagcagctg ccagagatgc
    13501 ccctgtgttt gcttgtagag gatacccgcc ctctgcatat gcacctcgct gagctagggt
    13561 ttcagcccca catctacggc ccggattttc gtctgttgac tccagaactg gcggcctcac
    13621 tacgtaccct gggcattggc ctcgtgccct ggaccgtgaa cgagccggct gatctacggc
    13681 gcatgttgca gctgcatcct accggcatca ccaccgacta tccggaccgt ttgatggccc
    13741 ttcggtcagc ggtataataa tggcatagtc ggattgcaga tagcacaaaa cgtgtctcgc
    13801 aggagctcta tcacttcagg aactgacaca aacaatacag gtgtaatatt aaatctgtaa
    13861 cagattggtg tattacatcg aacaaatgaa tgagcgttac aggatggcag tgtaatgaat
    13921 tgtataacgt tacagagata catttattaa cagtgtatca gtgttgtctt tgtatcatct
    13981 gttcttggtt acatgaaaca gattgtacat atttacataa gttcagatta ttacacgttt
    14041 ccccctatgt cacatcaagg tgaaatactg caggaagtca tcaaaaacag cggaatttcc
    14101 attacgcgta tcgtggacga attgggtatt acacgtccca ccatataccg taagttcaag
    14161 gatgaaacac ttgattacaa cttcgtaaag cgtattgggg aaataatcgg acacgacttt
    14221 tcgcaggatt ttacatcatt gcatcaggtg gtgttgccgt tttctgttac accagtgtca
    14281 catggtgtat ctgtaatgtc tgacaaaggt gtaacacata aatcaactgt tacaccgatg
    14341 attgagtcgg atagtctaaa acagctaatg cagcttcagc agaagtatat tgccttgcta
    14401 gaagcctata atgaactgtt gctaaaagtg tacggaccta agtaataaat ttgttccacg
    14461 tgaaacatat ctgtcgcata caagtaggtt ggctttgata cacctgctca ttgcctgacg
    14521 gatacctagt tctcatcagg ccacatgtta caggcggaca agtgcaggga taaggtggat
    14581 tgacggaatg aagcaggtgg ccagtgtaaa gagcgacagt ggaaatcgta cgggtttcaa
    14641 aagcagtgaa agtgagtagt aggtaggtct gtcaacaatg gtctagctgg gttgtgctag
    14701 taatgctggt agcgctggca gtggagaacg gagccttgta taggtgccgg aggtaggtgg
    14761 ttagatgcgg gtagcgggcc gtatctttcg gcagtcgttt taccttcttc gtttcagtct
    14821 tgcatgtctg ctgaccacct gcctgcttac cgcccggtgt ctcattcccg ggttacgctt
    14881 accgagttga tgattccttc ctacgccaac tttgggggta agatccacgg aggaattctt
    14941 ctctctctca tggacaaggt agcctacgcg gcggcctcca aacatgccgg aacctactgc
    15001 gtcacggtga gtgtggatgg ggtgaatttc ttgcagccgg tagaggtagg ggagttggtt
    15061 tcgttactgg cttcggtgaa ctatgtgggc cgaacgtccc tccttgtcgg catcaaggta
    15121 attgccgaag acgtgcgtag cgggtcggtc aaacatacta acacctgcta cttcacgatg
    15181 gtcgctaagg atgatgaagg ccggcccagc caggtgcccg gcttgctcct ggaaacccct
    15241 gatgataccc gccgctttct ggaagccatc aagcgccgtg agttcaagga gcagtaccgc
    15301 caggagtttg ataatgcccg ctccatcctg gccctggagg agcagcagca cttattggaa
    15361 aaggagcggt gccagttggg ctactagtgt ggtgttggag tcgcggagcc tcaatacaga
    15421 ctttttagtg agagtccctg tatatcgggg agtaagccag acccagagct acaacccgtt
    15481 gttcctgctg gcagattagc cgggtagggg gagggcattt gacccagtcg ctactgcggc
    15541 accatccggt cgggttccaa tcctttctct ttagctactc ataaggacat ctcccagcgt
    15601 agcagcgcaa gcttgggtag tggcatacct gccataaaga accggcccca gcttttgagc
    15661 cagggccggt agtgctttct aataagacgc gcttttcacc tataggaata cgacttcctt
    15721 tatgatgtcc tcgccgactt cggcgttgag gttttccagt acccgagtct tggccatgaa
    15781 cagttcgtgc ttgagcggag cggatgaaag ccgtacaaac agcttgttgt tgctcacgta
    15841 tacctgctgg gttttcatgg ccacggcctt acccattacc ttctcccaac tagccactac
    15901 tgttacctcg ttgagtttgc cctggagccg ataaacgcgc aatagtgcct taataccatc
    15961 ccttagtgga acaatatcgg actggcgtga attttcggag gaatgtggtt ttttaagcgc
    16021 cattacagtt attaacgcgc gagaaaactc ttctcgcacc gggcttcaaa gataccaccc
    16081 accttaccta aagcggctgc acacttccca actctacccg gaaccggcgg atatcttcgg
    16141 agaggtcggc cagtacccgg tcggtgcgct ccaggtgagt atcggtcagg aaaatctggc
    16201 cgaaggtatg attggctacc agctgcataa ggcgggtgat gcgcttctca tctagtcggt
    16261 cgaagatgtc atcgaggagc agcagcggct tttgctgctt gtgcgcggcc aggatttcaa
    16321 actgcgccag cttgagggca atggcaaacg acttctgctg cccctgcgag ccataccctt
    16381 ttaccggtag ctcatccata agaaacgtga agtcatcacg gtgggggccg gtggtagtgc
    16441 gttgcagcgt gaggtccttg cgctcattca gacgaagcag tttcaggaag tcggctcccg
    16501 gcagctcact cttataggta agagtcacga cctcgcgggc atcggctagc tgctcatagt
    16561 gacgctggaa gatgggctcg aattccgtga gaaattcttg ccgccgctgc actagctgct
    16621 cgcccacggg ggccagctgc tcatccagca ctaataggta gtcccggtcg taaccggctt
    16681 ggcggtcagc ggccagcttg agcagggaat tgcgctgctt cagcaggtgc gtgtaccgga
    16741 ttagctgctc cagatacgtg tggtcgagtt gggagaggag gctgtcgaaa tacttgcgcc
    16801 gttcctcgct gccctgccgg atcaggtcag tatcgtaggg cgagataagc accaccgggt
    16861 accgcccaat atggtccgat acccgctcgt aagcctgctt gtcgtgggtt acggttttct
    16921 tctggccctg acgtagactg cactgaatgg tttcaggctt ttcgtcgggt gcgggacgga
    16981 agcgcccccg caccacaaac agctcttcgc cctgcttaat actctgggcg tcggaaaccg
    17041 taaaggcact cttagtgagg gagaggtagt ggattgcgtc gagcagattc gtcttgccgc
    17101 tgccgttgtc acccacaaag cagttgatgt gggcggagaa gctcagattg gcttcttcgt
    17161 agtttttgaa gaacagcaga tggaggcttt cgaggttcat gcttaaggtt cggaattgca
    17221 atccttttac gtactttcgc atcccaaacg cgaacaaccg aaagcaagat ggcggagacg
    17281 aaagtaaagg ctgcccccaa ggcttccaat tcgacgaaga aatcgtcggc cccgaaagcg
    17341 gcccccaagg ggaaagctgc ggctactaaa acagccaagc agcccgatcc ggtattgcct
    17401 ccttccactg aggaaggcaa ggcagctacg ggaactccta aagcaacgag cccggcccag
    17461 ccggagtttt cgaaggaaac ctacctcact tggtatgagc agatgcagct catgcgcaag
    17521 tttgaggaga aggctggtca gctgtacggt caacagaaga ttaaaggttt ctgccacctc
    17581 tacataggcc aggaggcctg cgtagctggt gccgtgtcgg ccctcaccaa ggacgacaag
    17641 tggattactg cttaccgtga ccatgcccac ccgctggccc tcggtacttc gcccaacgcc
    17701 atcatggccg agctctatgc caaagctacc ggttgctcta agggcaaagg cggctccatg
    17761 cacatgttcg ataaggaagt aaacttcatc ggtggccacg gcatcgtggg ggcgcaggta
    17821 cctatgggtg ccggcatcgg tttcgccgag aagtataata agacgggcaa cctgtgcatc
    17881 tgctatatgg gcgacggtgc cgttcggcag ggtgccttgc acgaagcctt caacatggcc
    17941 atgctgtgga agctgccggt catcttcgtg gtggaaaaca acggctacgc tatgggtacc
    18001 tcggtacagc gcacgtccaa cgtgacggaa ctgcaccaca ttggccgtgg ctacgacatg
    18061 ccctctgagc cggtgaatgc catgaacgta gaggacgtgc ataatgccgt ggcacgcgcc
    18121 gccgagcggg cccgggccgg tgaaggccct accttcctcg agtttaaaac ttaccgctac
    18181 aaaggtcatt ccatgagcga cccggccaag taccgcacca aagaggagct ggaagactac
    18241 cgctcccgcg acgccatcga agccgtacgc cacaccatcc tgacgcacaa catggctacc
    18301 gaagaggacc tggcggccat tgatgagaag atcaaaggac aggtggccga gtcggtggag
    18361 tttgccgaga actcgccctt ccctacagcc gacgagctgt acaaggacgt gtacgtacaa
    18421 caggactacc cctacatccg cgactagctc gccggaaggt tatcgggccg ctgtcggcgg
    18481 ccgccttttt gagtaatacc catgtcgaag attccgttca caggcaaaag ccagcaagcg
    18541 cgtcagcagc aacagcgcgt tgtctctcct gaccccacgc agccgctgga ggcgtacaac
    18601 cccgagcatc cgctgctgga agaccccgat gccttggcta ttcgcctggt ggaatcggaa
    18661 gacttcgtgc ggcgcaacaa gaacgtgctg ctgggtttgc tggccgtggt agtactggcc
    18721 gtggctggtg gcttcggcta ctacctgtgg cgaggctccc aggataccaa agggcaagca
    18781 gccctgttcc aggcggtaag ctattgggaa gccgactctt tgcagaaagc catgaaaggc
    18841 gacggccgca acctggggtt ggagcgcgtg gcatcagagt acagtggcac cgacgctggt
    18901 aacctagcca acttctacgc cggtgtggct gctttgaaag aaggcaaaaa taaagaggcc
    18961 atcgactacc ttgaagactt cagttccgat gactacttgg tgcaggctcg agcgtattcc
    19021 ctactaggtg atgcgcacct ggaaatgaac caggccaaag aagccgctga cttctataac
    19081 aaagccgcta attataatgc taacgagttc ttctcgcccg gctacctgct gaaggaagct
    19141 acggcccgcg aagccgctaa ggattatgaa ggtgccatta cggcgtacaa caaaatcctg
    19201 accgactacg cttcggcggc ggaggctacg gaagccaagg aatacaaggc ccgcgccgaa
    19261 gccctggctg gtaaataaac atagctcagc atttctgtat tctgcacaag aggcggcccc
    19321 cgggtcgcct cttgtgtttt caggaccagc cggccggagt agaaaccgtc ccctatcttt
    19381 gaccgcacgg agctactagc ttctcttacc tgtttaaacc tccccgccgc atggctacct
    19441 ctctcaaaaa tctgagcgac tatacttccg accacttcgt tgacatcagc gagaaacgct
    19501 ttgggctggt ggtggccgag tggaaccgcg aaatcaccga caccctggcc cagggcgcgt
    19561 tcgacacgct cctcaaacac ggagccaaac ccgagaacat cttccgcaac acggtgcccg
    19621 gcagcttcga actgacgctg ggggcccagc tactggccca gcatgaggaa attgacgcgg
    19681 ttatctgcct gggtgtcgtt atccaaggcg aaaccaagca tgatgactat atctgccacg
    19741 cggtggccag cggcatcacc aacgtgagcc tgaagttcaa caagccggtc atcttcgggc
    19801 tggtgaccac caacacactg gagcaggcct gggaccgggc cggtggcaag cacggtaaca
    19861 aaggtgtgga aggggcagtg gctgccatcc atatgctggg tttctagacg agccttacct
    19921 gactcgtcgg caaaaaccgg ggccggaggg ggtatcgtgc agattagcag acaaagccgt
    19981 agctttgcgg ccggaaatag tctggctatc gggaccaccg gagctagtag gagcagtccg
    20041 gctgctgaag gctatgcgca aaaaggacaa acttattcgc gcaggctgct gttgggcgta
    20101 actactggct gttcagtggc tgccgaaact ggcatcctag caaataacat agtttcatat
    20161 aacctcttcc tgcaacgaca tgagtgaagc acccctacgc tattccaggg aagaactggc
    20221 tgagtttgag caaatcattc aggacaaggt cacggccgcc cgcaaggaag tagcgtttat
    20281 caaagaaacc ctgagccgca aaaacgatac cggcaccgac aacacagctt cttcttcgaa
    20341 ggtgctggaa gacggagccg atacggccga aaaggaaagc ctgaaccagt tggcctcacg
    20401 ccagatgaag ttcatccagc agctcgaaaa cgccctgatc cgtatcaaga atggcaccta
    20461 cggtgtctgc attggtaccg gcaagctgat tccgaaggaa cgcctgcgtg ccgtaccgca
    20521 cacgcagcat tccattgaag ccaagatggc ccgccgcgac taacctcgct tttggctctt
    20581 attactgccc ggacttgtgg ccggcctgta ctttttggta cagccggttg ctggtccggg
    20641 cactgttttc ggcggcttgt cgttaggcaa gcttccgcct gtatctgatt attaacctgt
    20701 accgtagcga tacggcacgc acgcttcttc cacatgggca agaaacactt ctccggcgat
    20761 gcgcccggcc gccgtggccg taccaccggc tccggccgtc ctgctgacag ccgtaacaat
    20821 gacagccgta acaatgacag ccgcggcaac gacaaccgtt cttcggataa ccgaggcaac
    20881 gagggattcc gcaagtttat acagcccggt caggagcgca cggagcgcac gggcggcaac
    20941 ccgcgcttcg gccagaatgg gggcggctca ga
//
