LOCUS       NZ_KI912410            10831 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Actinomadura oligospora ATCC 43269 P696DRAFT_scaffold00001.1, whole
            genome shotgun sequence.
ACCESSION   NZ_KI912410
VERSION     NZ_KI912410.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Actinomadura oligospora ATCC 43269
  ORGANISM  Actinomadura oligospora ATCC 43269
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 1148980)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-2014) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Actinomadura oligospora ATCC 43269
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: ATCC 43269
            GOLD Stamp ID                     :: Gi22378
            Type Strain                       :: Yes
            Isolation Site                    :: soil, India
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-09-10
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000518265.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 02:24:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,332
            CDSs (total)                      :: 8,253
            Genes (coding)                    :: 8,185
            CDSs (with protein)               :: 8,185
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 2 (5S, 16S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 7 of 68
            Pseudo Genes (incomplete)         :: 65 of 68
            Pseudo Genes (internal stop)      :: 1 of 68
            Pseudo Genes (multiple problems)  :: 5 of 68
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:28:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 878819
            Orig. end                         :: 889650
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KI912410.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 1013217
            Source DNA and organism available from Tim Lilburn at the American
            Type Culture Collection (ATCC) (TLilburn@atcc.org)
            Contacts: Nikos   Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI
            Annotation by JGI
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10831
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10831
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10831
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5831](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5831)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(313..888)
                     /locus_tag="P696_RS0135815"
     CDS             complement(313..888)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597312.1"
                     /locus_tag="P696_RS0135815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_026416095.1"
                     /transl_table=11
                     /translation="MGRPARHDRDRLLDAAVDLAFEAGPSGVTVAAVARSAGAPSGSVY
                     HRFPSAMALLAAVWLRTLERFQDGFVAAASGEPAGRAAVDAARQVVSWSRAHPREALLL
                     QYGPRDFGQAEWPDADKDRLAHGNRRVQYALTDLAARLGHAADPGRVVLAVVDVPQSLV
                     RRHLREGTPIPESAEDLVAEAATALLKL"
     misc_feature    complement(939..948)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            959..1645
                     /locus_tag="P696_RS0135820"
     CDS             959..1645
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017559553.1"
                     /locus_tag="P696_RS0135820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_026416096.1"
                     /transl_table=11
                     /translation="MNTASGLPPGQVPAGHRPFGLPRFGPVVPRPRGTASVTVTGAVRH
                     PGQVSAAELAALPGRTDRVADLHCVTTWSALGLSWSGVPFRDVHAYLTDLVAVRQAVRW
                     VTFTGLDGFSATLRLDDALAPDVLLADALDGASLGPDQGAPLRLVAPAHYGYKSVKHVC
                     QIEYRTAYAAGPAGWKAHPRGRVAHEERSRYLPGRVWRPLWRALLPRSRAAYESARART
                     NGRGRP"
     gene            1642..2049
                     /locus_tag="P696_RS50315"
     CDS             1642..2049
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039463.3"
                     /locus_tag="P696_RS50315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6463 family protein"
                     /protein_id="WP_051468548.1"
                     /transl_table=11
                     /translation="MNGLNRWVPRLIIATSVLHFVWAFVQPNAWDDIVRDGFAATVVDT
                     DAPGYWNREASVWFLTAGALLLVLGTMTRLAVRLTGRIPAQVGWFLLATGVPLCAIYFP
                     VTGSWALVVLGVLALIASYRAPAAAPEAASR"
     gene            complement(2090..2689)
                     /locus_tag="P696_RS0135830"
     CDS             complement(2090..2689)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017563933.1"
                     /locus_tag="P696_RS0135830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_026416097.1"
                     /transl_table=11
                     /translation="MSPRGVPMTDVRRQLFDAAERVLVREGPGALSGRAVTREAGCATG
                     LLYNHFPDFDEFLAEFVLDRVRPTADRLALLPGRAGAGTVSGNLTDGATLLLEPTPLAL
                     TNLVRARPPLLHRMHTVAREEMPELHAGEAAFADYLDAEKALGRVAADTDAEAVALALV
                     GAVHQLLLSHPVDEPDLRGRIERVVTVLIKGLATAE"
     misc_feature    complement(2683..2693)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2771..3931
                     /locus_tag="P696_RS0135835"
     CDS             2771..3931
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="P696_RS0135835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_034488395.1"
                     /transl_table=11
                     /translation="MGSDIRRAIVVGAGIAGLTTALRLRGIGWDVLLLERAPARRRGGY
                     ALTLTGGGHAAAEALGILPGLRERHFDVDLLFVNADGGRRFTLPADRAEALRGGRALNL
                     LRGDIEDVLFTAVPDDVEVRFGATVTSIAQDEDGVRAVLDDGTTERADLLVGADGLHSA
                     VRDLAFDVGPSVLRDLGYTVAAFSLRKLPAGLAERAVTTFSPPGRSIAVASLGRDRAAA
                     YFIHKSSDPAGDRALGPEQTLANRYGDLGWVVPDLLGQLADTDSVYFDGVAQIAADRWH
                     RGRVVLVGDAAWCLTPFSGYGASLSMAGADLLGTALEAEPADIPAALTAWEARLRPEAD
                     RFQTRARRAAAMHAPSTRSELLRRDFLLRAASLRPVTHVLAHLSRH"
     gene            complement(3984..4109)
                     /locus_tag="P696_RS58945"
     CDS             complement(3984..4109)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P696_RS58945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_281175022.1"
                     /transl_table=11
                     /translation="MEPQLTEEEKTDQEFTLEPVEDHSDTTAESSAGCSSCACSR"
     gene            complement(4234..5001)
                     /locus_tag="P696_RS0135845"
     CDS             complement(4234..5001)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P696_RS0135845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_026416099.1"
                     /transl_table=11
                     /translation="MGLADALAAMLTNEDDLALLRRDPTALRDRFALTENELAMLAGAG
                     PAGYRVTRRNVQAKLRRAIGGCLPVTVAHLHRHHPDLWERFASGLVRPPQPVHRHGIWE
                     SERLTDWLTARDLAPVADYARYELERAKLRRADHDRTGRDPADVLGPGTGTGTDRPLTL
                     SSDVRILMFDHDVTAGPPLADLPVRRTHVVLHRPSPSSHLQTYRVSPGTALLLAGCDGT
                     RTTQQLVACAASDPAAVRTALDRLMAADLVRPA"
     gene            complement(5001..5831)
                     /locus_tag="P696_RS0135850"
     CDS             complement(5001..5831)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003818.1"
                     /locus_tag="P696_RS0135850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_211245930.1"
                     /sec_met_domain="DUF692 (E-value: 4.4e-79, bitscore: 261.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRLGSGLGYRAELAEDIDLHADRIDWLEVISEHFLFAREARERL
                     RELARRFPVVPHGVELSIGSDREPDAAYLEALASLVEDVDAPWFSDHLCFTRTDEVALG
                     LLAPLPRTRQVARRLAGRADWVRRTVGRPFLLENITYYVDLATPLTEAQFIAEVLEHCD
                     CGLLLDVANLDINARNHGFDPLDFLDTLPLERVVQVHLAGAGEEEEMTLDTHSEAVPAR
                     VWDLLEEVVARTPVQAALIERDANFPDDFTELLDEVGRARTVLASRPAELIGGA"
     gene            6053..6562
                     /locus_tag="P696_RS0135855"
     CDS             6053..6562
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887447.1"
                     /locus_tag="P696_RS0135855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SigE family RNA polymerase sigma factor"
                     /protein_id="WP_342669052.1"
                     /transl_table=11
                     /translation="MSEFVAARGPALLRSAFLLTGDRHLAEDLVQAALVKLAPRWRRVA
                     AGGDPESYVRKILYHEHLNWWKRRGRHVHPSADPPEPAGHPDIADRAVRTILLGQALGR
                     LTAKQRAMIVLRFYEDRSETETARLLGCSVGTVKSQTHRALARLRALEPGLADLLTDTE
                     IPEVAR"
     gene            6559..7758
                     /locus_tag="P696_RS0135860"
     CDS             6559..7758
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P696_RS0135860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_026416102.1"
                     /transl_table=11
                     /translation="MSPRLHDALHELAQGAPSEVSAAQVLAGARRRRRVRLIAVPSVAA
                     TAAAAILVGATLAGGGAEPARPAAQPDRPLVTEPGKVLNPPGVLPGRLPSGKVEPIVFA
                     FLDYCRGKSLKETTSAKGDCAQWRLVGRSGKQWRLPDAVGSRVVKPEDYMSGSAPLVVS
                     PDGWRIAYYRAKDQRLVVRDLTSGRVTPVSARTAPAAIPLMMFSGDGTRLALSPKVDQS
                     GRTLLVDTRTGAATALHAGTVIGLSRDASTIVQADTEDERTPLTVSGADGSVRASVPLD
                     PEVDLRGSSGNLLSPDGRTLLTFTTSLDKAVLVDVATGKITSVRRIDGVGGAHAWTGPT
                     TYFTTRDLSGHPDARKRGIPPRALRGVIVDLTTGKYRDVGRTFTIQTSQSAVALGGYLP
                     "
     gene            8065..9183
                     /locus_tag="P696_RS50320"
     CDS             8065..9183
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S41"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015531.4"
                     /locus_tag="P696_RS50320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S41 family peptidase"
                     /protein_id="WP_211245931.1"
                     /sec_met_domain="Peptidase_S41 (E-value: 9e-26, bitscore:
                     86.4, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRKRPALAAIGAAVLAGGILVASGVHPGTTASAALVKTTRPAAL
                     HDDHAGYQGPGGPGGPMQDPHPWGLGVGLNYTLPRAETAPDFTGPLFLSTVGAGTPAAA
                     AGLKPGDVIESVNGVPAFTNGKLNSGILDYLRPPYPQRTPVTLTVQRPATGKTRKVSVT
                     PGELAAQPKPHVDATLVNGSVARIRFDAFYPGVAKDVLKAIADLRATTELTGVIFDVRG
                     NRGGVAAEGNVLLGAFVHDATVMSFCNANGTCDPQRVDDSTPLLHLPMVTLTDDGCASA
                     CDAFAMGVKDLHLGKLVGTRTAGANSGPTQLYALNDNTSVIRFPSQRAIGANGEIMDGI
                     GVPPDFHAPLTAADASAGKDPALAKAAALLKP"
     gene            complement(9307..9927)
                     /locus_tag="P696_RS0135870"
     CDS             complement(9307..9927)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591509.1"
                     /locus_tag="P696_RS0135870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysE family translocator"
                     /protein_id="WP_026416103.1"
                     /transl_table=11
                     /translation="MLSTLFAFLGACTLIAASPGPSTMLIIRQSLRSRRAGFLTVLGNE
                     TGVFIWGVIAALGLTALLAASQLAYDVMRIAGAVTLVGFGIKTLLDVRGERGEEERQDA
                     QAVHSGWASYRSGLLLNLANPKAAVFAMSFLPQFVPAGAPHLPTMIGLAAIWAVFEVGY
                     YGLYVWFVGRMKKIISRAKVRQRLEWVSGTVLVLLGVRMAMES"
     gene            complement(10109..10681)
                     /locus_tag="P696_RS0135875"
     CDS             complement(10109..10681)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017604402.1"
                     /locus_tag="P696_RS0135875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_026416104.1"
                     /transl_table=11
                     /translation="MRTLISTAFVSTDGVVEGPGGEPGYRNSGWTFKDVEFVPEAFEIK
                     GREQEEAAAMMMGRASYEAFSKVWPGMAEFARYKTLPKYVVSTTMTEDDLVDDWGDTTI
                     LRSLDEVAALKETDGGPIIVHGSASLNHALSDAGLIDRYHLLVFPVLLGAGKRLFSTTD
                     KDTQKLKLVEHAVYSNGLQKQILDVLH"
     misc_feature    10649..10660
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    10808..10819
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.94"
                     /tool="antismash"
ORIGIN
        1 cctcactcgc tccgggttcg tcgacaccag gtccaaaggt caaccaccct gccaggccac
       61 acctaaggtc gttgtgaaga acagggagag gaccaggccc gcaatctacc gtcccgagcc
      121 cgaagatgcc gctcccggcg accgccgatc accgaccgaa atccccgcac gcccctgctg
      181 ggcgccgcga aaccccttcc ggcggggctg accaggcgtg atccggccgc gaccggcccg
      241 attccgagag ggccgtcgtg ggacggccgc cgtgagacgg ccggtccgat cttggaggct
      301 gggcgcgggc ggtcagagct tgagcagggc ggtggcggcc tcggcgacga ggtcctcggc
      361 ggactccggg atcggcgtcc cctcccggag atgacgcctg acgaggctct gcgggacgtc
      421 cacgacggcg aggacgacgc gtccggggtc ggccgcgtgg ccgaggcggg ccgccaggtc
      481 ggtcagcgcg tactggacgc gccggttgcc gtgggcgagg cggtccttgt cggcgtccgg
      541 ccattcggct tgtccgaaat cacgggggcc gtactggagc agcagcgcct cgcgggggtg
      601 ggcgcggctc caggagacga cctggcgggc ggcgtccacg gcggcgcgtc cggccggttc
      661 gccggacgcg gcggcgacga agccgtcctg gaagcgctcg agcgtgcgca gccagacggc
      721 cgccagcagc gccatcgcgc tggggaagcg gtggtagacc gagccgctcg gcgcgcccgc
      781 cgaacgcgcg acggccgcga ccgtgacgcc cgagggcccg gcctcgaagg ccaggtcgac
      841 ggccgcgtcc agcagccggt cgcggtcgtg ccgcgcaggt cgccccatgc ggcgagggta
      901 ccggtggggt acgctcccct caatattgga gatcgctctc taaaaacagg agggacgcgt
      961 gaacaccgca tccggcctgc cgccgggaca ggtcccggcc gggcaccgtc cgttcgggct
     1021 gccgcgcttc gggccggtcg tcccgcgtcc gcgtggcacg gcgtccgtga ccgtcacggg
     1081 ggccgtccgc catcccggcc aggtctcggc ggcggagctc gccgcgctgc cgggccgcac
     1141 cgaccgcgtc gccgacctgc actgcgtcac cacgtggagc gcgctcgggc tgtcctggag
     1201 cggggtgccg ttccgcgacg tccacgcgta tctcactgat ctggtggcgg tccgtcaggc
     1261 cgtgcgctgg gtcaccttca ccggcctgga cggcttctcg gccaccctgc gcctggacga
     1321 cgcgctcgcc ccggacgtcc ttctcgccga cgccctggac ggcgcgtccc tcgggcccga
     1381 ccagggcgcg ccgctgcggc tggtcgcccc ggcgcactac ggctacaaga gcgtcaagca
     1441 cgtctgccag atcgagtacc gcaccgccta cgccgcgggc cctgcgggct ggaaggccca
     1501 cccgcgcgga cgcgtcgcgc acgaggaacg cagccgctac ctgcccggac gcgtctggcg
     1561 tccgctctgg cgcgccctcc tgccgaggtc ccgcgccgcc tacgaatccg cccgcgcccg
     1621 cacgaacgga aggggacgac cgtgaacggc ctgaaccgct gggtcccgcg cctgatcatc
     1681 gcgacgtcgg tgctgcactt cgtctgggcg ttcgtccagc ccaacgcctg ggacgacatc
     1741 gtccgcgacg ggttcgccgc cacggtcgtc gacaccgacg cgcccggcta ctggaaccgc
     1801 gaggccagtg tctggttcct caccgcgggc gcgctgctgc tcgtcctcgg caccatgacc
     1861 cgcctggccg tccggctcac cgggcggatc cccgcccagg tcggctggtt cctcctcgcg
     1921 accggcgtcc cgctgtgcgc gatctacttc ccggtcacgg gtagctgggc gctggtcgtc
     1981 ctcggcgtcc tggccctgat cgcgtcctac cgcgcccccg ccgccgcgcc ggaggcggcc
     2041 tcccgctgac ccctcgtcga cgtccggccc tccgccaggg ccggacgtcc tattcggctg
     2101 tcgccaggcc cttgatcagg acggtcacga cgcgttcgat ccgtccgcgc aggtcgggct
     2161 cgtccacggg gtggctgagc agcagctggt ggacggcgcc gacgagcgcg agcgcgacag
     2221 cctcggcgtc ggtgtcggcg gcgacgcgtc cgagggcctt ctcggcgtcc aggtagtccg
     2281 cgaacgccgc ctcgccggcg tgcagctcgg gcatctcctc ccgcgcgacg gtgtgcatgc
     2341 ggtgcaggag cggcggacgg gcccggacca ggttcgtgag cgcgagcggg gtcggctcga
     2401 gcagcagggt cgcgccgtcg gtgaggttcc cggacaccgt cccggctccg gcccgtccgg
     2461 gtagcagggc cagccggtcg gccgtgggcc gcacccggtc gaggacgaac tcggccagga
     2521 actcgtcgaa gtccgggaag tggttgtaga gcaggccggt cgcgcatccg gcctcgcggg
     2581 tgacggcccg tccgctcagc gcgcccggcc cctcgcggac caggacgcgc tcggccgcgt
     2641 cgaagagctg ccgccggacg tcggtcatcg gcacaccacg gggtgacatg gcgatccact
     2701 ctaggccctg gacagggaat gaacagtcgc tcattatgat gagcactcgt tcatcatcaa
     2761 agggggagcc atgggttccg acatccggcg ggccatcgtc gtgggagcgg gcatcgcggg
     2821 actgaccacg gcgctgcgcc tgcgcggcat cggctgggac gtcctgctgc tcgaacgcgc
     2881 gcccgcccgc cgccggggcg gctacgccct gacgctgacc ggcgggggcc acgccgccgc
     2941 cgaagcgctc ggcatcctcc ccggcctgcg cgaacgccac ttcgacgtgg accttctctt
     3001 cgtcaacgcc gacggcggac ggcgcttcac cctccccgcc gaccgggccg aggccctccg
     3061 gggcgggcgg gccctcaacc tcctgcgcgg cgacatcgag gacgtcctgt tcaccgccgt
     3121 cccggacgac gtcgaggtcc gcttcggcgc gaccgtgacg tccatcgccc aggacgagga
     3181 cggcgtccgg gccgtcctcg acgacggcac caccgagcgc gcggacctcc tggtcggcgc
     3241 ggacggcctg cactcggccg tccgcgacct ggccttcgac gtcggaccgt ccgtcctccg
     3301 cgacctcggc tacaccgtcg ccgcgttcag cctgcggaaa ctccccgcgg gcctggcgga
     3361 gagggccgtc accacgttct cccctcccgg ccgcagcatc gccgtcgcgt ccctgggacg
     3421 ggaccgcgcc gccgcctact tcatccacaa gagctccgac cccgccgggg accgggccct
     3481 cggacccgaa cagaccctcg cgaaccgcta cggcgacctc ggctgggtcg tccccgacct
     3541 cctgggccag ctcgccgaca ccgactcggt ctacttcgac ggcgtcgccc agatcgccgc
     3601 cgaccgctgg caccggggac gcgtcgtcct cgtcggcgac gccgcctggt gcctcacccc
     3661 gttctccggc tacggcgcgt ccctgtcgat ggccggagcc gacctcctgg gcaccgccct
     3721 cgaagccgaa ccggccgaca tcccggccgc cctcaccgcc tgggaggccc ggctgcgccc
     3781 cgaggccgac cgcttccaga cccgggcacg ccgcgccgcc gcgatgcacg cgccgtccac
     3841 ccggtccgaa ctcctcaggc gcgacttcct gctgagggcc gcgagcctcc gccccgtgac
     3901 ccacgtcctc gcccacctgt cccgccactg aggacggtga gggcggggca cgggccgccc
     3961 cgccctcgtc tcggtgccgg cggtcacctg ctgcaggcgc aggagctgca gccggcagag
     4021 ctttcggcgg tcgtgtcgga gtggtcctcg acgggttcca gggtgaactc ctggtcggtc
     4081 ttctcctctt cggtgagctg cggctccatg gtccgttctc ccttcgtgag gggcccgccg
     4141 tccggcgggc ccggtgtcgg tggcccgttg gcgggccggg ttccccgcgc tcgcccgccg
     4201 ctcaggcgcg cgggcgcggg agccggtggg tgatcacgcg ggacgcacga ggtcggcggc
     4261 catgaggcgg tccagcgcgg tccggacggc ggcggggtcg ctggcggcgc aggcgacgag
     4321 ctgctgggtg gtgcgcgtgc cgtcgcagcc ggccagcagc agggcggtcc ccgggctgac
     4381 ccggtaggtc tgcaggtggg acgacgggga cggccggtgc aggacgacgt gggtacgccg
     4441 gaccgggaga tcggcgagcg ggggaccggc ggtgacgtca tggtcgaaca tcaggatccg
     4501 cacgtcgctc gacagcgtca gcggccggtc ggttccagtt ccagttccag gtccgaggac
     4561 gtccgccggg tctcgaccgg tcctgtcatg gtcggcgcgc cgcagcttgg cgcgttccag
     4621 ctcgtagcgg gcgtagtcgg ccaccggggc gaggtcgcgg gcggtgagcc agtccgtcag
     4681 ccgctcggac tcccagatgc cgtgcctgtg caccggctgc ggcggccgga cgagcccgga
     4741 cgcgaaccgt tcccacaggt cggggtggtg acggtgcagg tgggcgacgg tgacagggag
     4801 gcagcccccg atggcgcgcc gcagcttggc ctggacgttg cggcgggtga cccggtaacc
     4861 ggcgggcccg gctcccgcga gcatggccag ctcgttctcg gtcagcgcga accggtcgcg
     4921 gagcgccgtc gggtcccgcc ggagcagcgc gaggtcgtcc tcgttggtca gcatggcggc
     4981 cagcgcgtcc gccaggccca tcacgcgccg ccgatcagct cggcgggacg cgacgcgagg
     5041 acggtccggg cccggccgac ctcgtccagc agctcggtga agtcgtcggg gaagttggcg
     5101 tcccgctcga tgagcgcggc ctggaccggc gtgcgcgcga cgacctcctc cagcaggtcc
     5161 cacaccctgg ccgggaccgc ctcgctgtgc gtgtcgaggg tcatctcctc ctcctcgccc
     5221 gcaccggcca gatggacctg gacgacgcgt tcgaggggga gggtgtccag gaagtccagc
     5281 gggtcgaagc cgtggttgcg ggcgttgatg tcgaggttgg ccacgtccag cagcaggccg
     5341 cagtcgcagt gctccagcac ctcggcgatg aactgcgcct cggtcagcgg ggtggccagg
     5401 tccacgtagt aggtgatgtt ctccagcagg aacggccgtc cgaccgttcg ccgcacccag
     5461 tccgcccgtc cggccagacg ccgcgcgacc tgccgggtgc gcggcagggg agccaggagc
     5521 ccgagcgcca cctcgtccgt cctggtgaag cacaggtgat cgctgaacca gggcgcgtcg
     5581 acgtcctcga ccagggaggc cagcgcctcc aggtaggccg cgtccggctc ccggtcggac
     5641 ccgatggaca gctccacccc gtgcgggacg accgggaacc gccgagccag ctcccgcagc
     5701 cgctcccggg cctcgcgcgc gaacaggaag tgctcgctga tcacttccag ccagtcgatc
     5761 cggtcggcgt gcaggtcgat gtcctcggcc agctccgccc ggtaccccag ccccgatccc
     5821 agcctcggca acgtccccac cgtccgcccc tcaccgctcg aagcgcaaga attactgaca
     5881 gtgtcctttc ctggccatgc cagggcgacg cagaagttcc ggtcaacacc ccgcaaaccc
     5941 ttccccggcg agccgacgcc ttgatcgaat aatcctcgcc gggtgccaac ctttgccgcc
     6001 tctccggtgt gtgtaacggg gaacaaggag gcggatggtg cgatacgacg gcttgtccga
     6061 attcgttgcg gcgcggggac cggcgctgct gcggtcggcg ttcctgctca ccggtgaccg
     6121 gcatctcgcc gaggacctcg tgcaggccgc cctggtcaag ctcgcgcccc ggtggcggcg
     6181 cgtggcggcc ggcggcgatc ccgagtccta cgtgcgcaag atcctctacc acgagcatct
     6241 caactggtgg aagcgccgcg gcaggcacgt ccacccgagc gcggacccgc ccgagccggc
     6301 gggccatccc gacatcgccg accgcgcggt gcggacgatc ctcctgggcc aggcgctcgg
     6361 aaggctgacc gccaagcagc gcgcgatgat cgtgctgcgc ttctacgagg accgctccga
     6421 gaccgagacc gcgcggctgc tgggctgctc ggtcggcacg gtgaagagcc agacccaccg
     6481 cgccctcgcg cggctgcgcg ccctcgaacc cgggctcgcc gatctcctga ccgacaccga
     6541 gatcccggag gtggcgcgat gagcccccgc ctgcacgacg cactgcacga acttgcccag
     6601 ggggctccgt ccgaggtgag cgccgcccag gtcctggccg gtgcccgccg ccgcaggcgc
     6661 gtccgtctca tcgccgtccc ctccgtggcc gccaccgccg ccgcggcgat cctcgtcggg
     6721 gcgacgctgg ccggaggcgg tgccgagccc gccaggcccg ccgcacagcc tgaccggcct
     6781 ctggtcaccg agcccggcaa ggtcctcaac cctccgggcg tgctgcccgg gcgactgccg
     6841 tccggcaagg tcgaaccgat cgtgttcgcc ttcctcgact actgcagggg aaagagcctc
     6901 aaggagacga cgagcgccaa gggcgactgc gcccagtggc ggctggtcgg ccggtcgggg
     6961 aagcagtggc gcctgccgga cgcggtcggt tcgcgcgtgg tgaagccgga ggactacatg
     7021 agcggctccg cgccgctggt cgtcagcccg gacggatggc gcatcgccta ctaccgcgcg
     7081 aaggaccagc ggctcgtggt ccgcgacctg acctcgggaa gggtcacgcc ggtcagcgcg
     7141 cgcaccgctc cggcggccat ccccctgatg atgttctccg gcgacggaac acgcctcgcc
     7201 ctctccccga aggtggacca gagcggccgg acgctgctgg tcgacaccag aaccggagcc
     7261 gcgacggccc tgcacgccgg gaccgtgatc ggcctcagcc gggacgcctc cacgatcgtg
     7321 caggccgaca ccgaggacga gcggacgccc ctgaccgtct ccggcgcgga cggctccgtc
     7381 cgcgccagcg tcccgctcga tccggaggtc gacctgcgcg gctcctccgg caacctgctc
     7441 tctcccgacg ggcgcacgct cctcaccttc acgacgagtc tggacaaggc cgtcctcgtg
     7501 gacgtcgcca ccggcaagat cacctccgtg cgccggatcg acggcgtggg tggggcccat
     7561 gcctggacgg gcccgacgac gtacttcacc acgagggatc tgtccgggca cccggatgcg
     7621 cgcaagaggg ggataccgcc ccgggcccta cgaggcgtca tcgtcgacct gaccaccggc
     7681 aaataccgcg acgtcggcag gaccttcacg atccagacat cccagtccgc cgtggccctc
     7741 ggcggctacc tcccctgaac gccttggctc gggcctgggc tggggaggtg tggagggtta
     7801 cagcgccgtt atgccgctcc cggttgcatg gcgtcgcagc ttcttgatca cactgccacg
     7861 catcccccgg ggaacatcca tgcccttgtc gagcgccgct tccggctgcc tggtgctgca
     7921 gcgtgcgggt cgcagcggcg ccgctccgtc cgtgagaccg aaatgagttc gggagcactc
     7981 cacatgagta acgacatgcc ccctgccgac aagccgggcg accccgtgcc ggcgagccgg
     8041 cgggctggcc gccgccggac ccggatgacc cgaaagcggc ccgcactggc cgcgatcggc
     8101 gcggccgtac tggcaggtgg catcctcgtc gccagcggag tccatccggg cacgaccgcc
     8161 tccgccgccc tggtgaaaac gacacggccc gccgccctgc acgacgacca cgccgggtac
     8221 cagggccccg gcggtccggg cggccccatg caggaccccc acccgtgggg cctcggggtc
     8281 ggcctgaact acacccttcc ccgggcggag accgccccgg acttcaccgg gccgctcttc
     8341 ctcagcacgg tcggcgcggg cacccccgcc gccgcggccg ggctcaagcc aggtgacgtc
     8401 atcgagtcgg tgaacggcgt cccggccttc accaacggaa agctcaactc cggaatcctg
     8461 gactacctcc gcccgccgta cccgcagcgc acgccggtga ccctcaccgt tcagcggccc
     8521 gctaccggca agacccggaa ggtgagcgtc acccccggcg aactggccgc gcagcccaag
     8581 ccacacgtgg acgccaccct ggtgaacggc agcgtcgccc gcattcgctt cgacgccttc
     8641 tacccgggcg tcgccaagga cgtcctcaag gccatcgccg atctccgggc gaccaccgag
     8701 ctgaccggcg tcatcttcga tgtgcgcggc aaccgcggcg gggtcgccgc cgagggcaac
     8761 gtacttctgg gtgctttcgt ccacgacgcc acggtcatgt ccttctgcaa cgccaacggc
     8821 acctgcgacc cccagcgcgt ggacgacagc accccgctgc tccacctgcc gatggtcacg
     8881 ctcaccgacg acggctgcgc ctccgcgtgc gacgcgttcg ccatgggcgt caaggacctc
     8941 cacctgggca agctcgtcgg cacccgcacc gcgggggcca actccggccc cacccagctg
     9001 tacgcgctca acgacaacac cagcgtgatc cgcttcccct cccagcgcgc catcggcgcc
     9061 aacggcgaga tcatggacgg aatcggcgtc cccccggact tccacgcgcc gctcaccgcc
     9121 gcggacgcgt ccgcgggcaa agacccggcc ctggcaaagg cagcagctct cctcaagccg
     9181 taaccccggt cccccgcccc cagaactccc aagccacccc aatccagtag gtagtggcgg
     9241 gaagaacggt tgagcacgtt gcgcctcgac ggtctggtca gacttgaccc acggcgtcag
     9301 ccgccctcag ctctccatag ccatccgaac accaagaagg accagcacag tgccggagac
     9361 ccactcgagg cgctggcgta ccttggcccg ggagatgatc ttcttcatcc ggccgacgaa
     9421 ccatacgtac agtccgtagt agccgacctc gaagacggcc cagatggccg ccaggccgat
     9481 catggtgggc agatgagggg cgcctgcggg cacgaactgc ggcaggaagg acatcgcgaa
     9541 caccgcggcc ttggggttgg cgaggttcag cagtaggccc gagcggtacg aagcccagcc
     9601 cgagtgcact gcctgtgcat cctgtctctc ctcttctccc cgctcgccac ggacgtccaa
     9661 cagcgtcttg ataccgaagc cgaccagagt cacggccccg gcgatccgca tgacgtcgta
     9721 cgccaactga gaggccgcga gcagtgcggt gagcccgagt gccgcgatga caccccaaat
     9781 gaagacgccg gtctcgttgc ccagcaccgt gaggaaaccg gcacgtcggc tgcgcaggga
     9841 ctgtcggatg atcagcatcg tgctcgggcc gggcgaggcc gcgatcaggg tgcaggcgcc
     9901 gagaaaggcg aagagggtgc tcagcatgcg ccctatcgtg gagtctcact accgatcatg
     9961 tccatctggc cccctcggag cgggcggggc cgcttactgg gcgggtgcgg tggccgaggc
    10021 cggacagagt tgctgctctg tccggccgac gcgcctggag gcggattccg gtccgattcg
    10081 cctcacgccc ggccgttgtg cggtctggct agtggaggac gtcgaggatc tgcttctgca
    10141 gtccgttgct gtagacggcg tgctcgacga gcttgagctt ctgggtgtcc ttgtcggtgg
    10201 tgctgaacag gcgcttgccc gcgccgagca gcaccgggaa gaccagcagg tggtagcggt
    10261 cgatcaggcc ggcgtcagac agggcgtggt tgagcgaggc gctgccgtgg acgatgatcg
    10321 gcccgccgtc ggtctccttc agggcggcga cctcgtccag ggagcgcagg atcgtggtgt
    10381 cgccccagtc gtcgaccagg tcgtcctcgg tcatggtggt ggacacgacg tacttcggca
    10441 gggtcttgta ccgggcgaac tcggccatcc ccggccagac cttgctgaac gcctcgtagc
    10501 tggcgcggcc catcatcatc gcggccgcct cctcctgctc ccgccccttg atctcgaacg
    10561 cctccgggac gaactcgacg tccttgaacg tccagccgga gttgcggtag ccgggctcac
    10621 cgccggggcc ctccacaacg ccgtcggtgg agacgaacgc ggtgctgatc aacgtgcgca
    10681 tggcggatcc tcttgttctc gcgtatcggg gtgcgggcgc gtcgctcgtc ggcgcaagcg
    10741 tccggtggtg tcgtgcgacg ccgccaaagc ggtcaggtag ccagggcatt tatccgctct
    10801 gatcagggaa aacgctatgt ggatggcgtc c
//
