LOCUS       NZ_JADG01000011        23189 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Actinomadura oligospora ATCC 43269 P696DRAFT_scaffold00009.9_C,
            whole genome shotgun sequence.
ACCESSION   NZ_JADG01000011
VERSION     NZ_JADG01000011.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Actinomadura oligospora ATCC 43269
  ORGANISM  Actinomadura oligospora ATCC 43269
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 439683)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-2014) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Actinomadura oligospora ATCC 43269
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: ATCC 43269
            GOLD Stamp ID                     :: Gi22378
            Type Strain                       :: Yes
            Isolation Site                    :: soil, India
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-09-10
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000518265.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 02:24:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,332
            CDSs (total)                      :: 8,253
            Genes (coding)                    :: 8,185
            CDSs (with protein)               :: 8,185
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 2 (5S, 16S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 7 of 68
            Pseudo Genes (incomplete)         :: 65 of 68
            Pseudo Genes (internal stop)      :: 1 of 68
            Pseudo Genes (multiple problems)  :: 5 of 68
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:28:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 401934
            Orig. end                         :: 425123
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADG01000011.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..23189
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="3"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23189
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23189
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13189](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13189
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(197..212)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.27"
                     /tool="antismash"
     misc_feature    complement(336..349)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            380..1963
                     /locus_tag="P696_RS0119990"
     CDS             380..1963
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890025.1"
                     /locus_tag="P696_RS0119990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 13 protein"
                     /protein_id="WP_026413714.1"
                     /sec_met_domain="Alpha-amylase (E-value: 2.4e-75, bitscore:
                     248.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTPTTAWWRDAVIYQVYVRSFADASGDGIGDLAGIRSRLPYLA
                     DLGVDALWVTPFYVSPMADFGYDVADYRDVDPLFGTLDDARSLIADAHAHDLRVIVDVV
                     PNHSSDHHPWFRAALAAAPGSPERERYLFRDGRGADGSEPPNDWESVFGGPAWTRVPDG
                     QWYLHLFAPEQPDLNWENPGVRAEFEDILRFWLDLGVDGFRIDVAHGMVKAAGLPDVGH
                     TGQSEMLGTAVLPYFDQDGVHEIHRAWRKLLDSYPGERIGVAEAWAPDTARLARYTRPD
                     ELHQAFNFHYLGSPWDAAKLRDVIDGTLRAAGAAPATWVLSNHDVKRHVTRFGGGETGL
                     RRARAAALLTLALPGSAYVYQGEELGLPEVLDLPAEFRRDPQAGRGEDAGRDGCRVPIP
                     WNGDEPPFGFTAGPSTWLPMPPEWRALTVAAEEADPDSTLALYKTALRIRRAERALGDG
                     ALAWLDVPDGALAFTRRAADGTSVGCAVNTGAEPVRVPATGETLLSSAPVTREADGTLV
                     LPPDTTAWWR"
     gene            1974..3035
                     /locus_tag="P696_RS46835"
     CDS             1974..3035
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017587504.1"
                     /locus_tag="P696_RS46835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_051467902.1"
                     /transl_table=11
                     /translation="MTTPTRLADIAEHAGVSEATVSRVLNGRPGVSATTRQSVLAALDV
                     LGYERPARLRQQRAGLIGLIIPELTNPIFPAFAEIIESALARHGYMAVLCSQTPGGVAE
                     DDYLEMLLERGVAGVIFVNGLHANANSDRARYARLTEQGLPIVLVNGHRPDIDAPFVSN
                     DDVASLEAAVAHLGSLGHRRIGLAIGQDVYVPTRRKTEGFRRGLATLLGPSADTEGLVV
                     NTMYTVEGGQAAAQKLLDRGCTAICCGNDIMALGAIRAVRQRGLRVPEDVSVVGFDDSP
                     LTAYLDPPLTTIRQSVREMALAAVSTVLEEVGGGRPPRTELLYRPELVVRRSTAPAPVP
                     AAPAPTSPEHLVN"
     CDS             complement(3028..3237)
                     /gene="allorf_404962_405171"
                     /locus_tag="allorf_404962_405171"
                     /protein_id="allorf_404962_405171"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGPSRSFVGGSVGALPRSKERDPAHCQSSATQPLSTRTPRSRRIG
                     AFGELPRAGRRPARGLVGEVPGIS"
     CDS_motif       complement(3196..3237)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGPSRSFVGGSVGA"
                     /locus_tag="allorf_404962_405171_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(3028..3195)
                     /prepeptide="core"
                     /locus_tag="allorf_404962_405171_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="5772.5"
                     /monoisotopic_mass="5769.2"
                     /core_sequence="LPRSKERDPAHCQSSATQPLSTRTPRSRRIGAFGELPRAGRRP
                     ARGLVGEVPGIS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGPSRSFVGGSVGA"
                     /leader_location="[3195:3237](-)"
                     /alternative_weights="5790.5"
                     /alternative_weights="5808.5"
                     /alternative_weights="5826.6"
                     /alternative_weights="5844.6"
                     /alternative_weights="5862.6"
                     /alternative_weights="5880.6"
                     /alternative_weights="5898.6"
                     /alternative_weights="5916.7"
     misc_feature    complement(3134..3145)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    3162..3177
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(3189..3203)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    3190..3204
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     gene            3238..4530
                     /locus_tag="P696_RS0120000"
     CDS             3238..4530
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012852094.1"
                     /locus_tag="P696_RS0120000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_026413715.1"
                     /transl_table=11
                     /translation="MRGYRLRTVAVLATAGVLAAACGGGGDDSKSGKNFTLTVDVFGEF
                     GYENLYKGFEQAHPGVTVKQRKVSSLDDYKPRIQQWIATGSGAGDVVALEEGILPTYMQ
                     QRSKFVNLFDFGARSMRGDFLPWKWQSGLSPDGSQLVGLGTDVGPLAMCYRKDLFKKAG
                     LPSERDEVGKLWPTWDQFLATGQKFQGKVSGTKWLDGPTAVLRATVLQNAGSGPGYSFF
                     DKDDTFVFDTNPAVKQAFDTTLKFEQNKMTSDMSIFTPPWQTALKRDTFATVPCPSWML
                     GGIKQFSGDFGKGKWDVATTPGGSGYWGGSWLAVPKQSRHQKEAAALAQYLTGTQSQVG
                     AFKDKDTFPSNVKAEQDPAVSGATNDYFSGAPTGKIFGQLVSSVKPVHLGPKNEDVRQA
                     VENVLIAVGQGKVKPEDAWAKAVDAAKKAAR"
     gene            4583..5548
                     /locus_tag="P696_RS0120005"
     CDS             4583..5548
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889990.1"
                     /locus_tag="P696_RS0120005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_026413716.1"
                     /transl_table=11
                     /translation="MTSVDTRPVRPSSRADGAPRASRWRARLDRLDLKASPYLFVAPFF
                     VVFLVFGGYPLVYTLWVSLHDWGLSSGTREWAGFGNYGYLFGDDQFWHALVNTVGIFVL
                     STVPQLLLALLLANTLNRRMRGATVFRIGVVAPLITSMAAVAIVFGQLFDTDYGFVNWL
                     LQSHIDWHASRAWSWTAISVMVDWRWTGYNALIFLAAMQAIPKDLYEAAAIDGASRMRQ
                     FWQITVPLLRPTILFTVIISTIGGLQLFTEPVLFGGATSNKMDGGATHQFQTLTMYMYD
                     NAFGHDRYGYGAAIAWALFLLIIAFSLLNFLFVRRAGGTR"
     gene            5545..6426
                     /locus_tag="P696_RS0120010"
     CDS             5545..6426
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017625791.1"
                     /locus_tag="P696_RS0120010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_051467903.1"
                     /transl_table=11
                     /translation="MTIPAPLSRPARSTARRLHGLWEASPLTYLTLLVAVVLSVAPIYW
                     MFVVATRTNDVVANVPPPVVPGGHLGSNLNRLFDNPDAYFAKGLLNSFVVASCVTVSTV
                     FFASLAGFAFAKLRFRGRNALLLTIVATMMIPVQMGIIPLYMIMVRLGWQNHLQSVIVP
                     FLVTGFGVFMMRQYAAQAVPDELIEAARVDGCTTFGVYWRVVLPALRPAAGVLGLFTFM
                     QTWNDFMWPLAVLNPENPTVQLSINNLANGHFNDYTLMFAGTTVAVLPLLLVFVAFGRQ
                     IIGGIMEGAVKA"
     gene            6423..7847
                     /locus_tag="P696_RS0120015"
     CDS             6423..7847
                     /EC_number="3.2.1.21"
                     /GO_function="GO:0008422 - beta-glucosidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030245 - cellulose catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565649.1"
                     /locus_tag="P696_RS0120015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH1 family beta-glucosidase"
                     /protein_id="WP_026413718.1"
                     /transl_table=11
                     /translation="MSGKGANGQGTSKQGTSARVDFPDGFRWGAATAAYQVEGATDADG
                     RVPSIWDTFVRRPGAVLGGDTGDVAVDQYHRFREDVAIMRNLGLTAYRFSVAWPRAEAP
                     GGRGLGFYERLVDALLDAGIEPWPTLYHWDLPQSLEDAGGWPVRDTAHRFADYAARVHL
                     VLGDRVRNWLTVNEPWCAAFLGYASGDHAPGRREPGAALSAAHHLMLGHGLAVQAMRAE
                     RPDNRFGAAVNLYAISPASDAEADVDAARRVDGLQNRFFLDPLLLGRYPEDVLADVERF
                     GFAPPDADLAVINQPIDHLGVNYYSRHTVSGDPDSAPQAAASPFAEHSPWVGSGHVRFP
                     STGRPVTGMGWEIDPSGLTDVLVRLHEEYPAVDLCVTENGAGYQEEPSNGTVHDAERIA
                     YLDGHLRACHDAISAGVPLRGYFTWSLLDNFEWAWGYSRRFGLVHVDYATLRRAPKDSA
                     RWYAEVIRRGGLGDRG"
     gene            7872..8882
                     /locus_tag="P696_RS0120020"
     CDS             7872..8882
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631334.1"
                     /locus_tag="P696_RS0120020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_026413719.1"
                     /transl_table=11
                     /translation="MAGRGTRPTLEEVAALAGVGRGTVSRVINGSPRVSSRARDAVLAA
                     IDELGYVPNRAARTLVTRRTETVALVVAESELRLFDEPFFAGMIRGVSAALNETGLQLL
                     LALARSPAEYERLEQYLTAQHVDGVLLTSLHAEDPLPGRLEASGVPTVLGGRPPGIEPV
                     SYVDVDNRSGARQAVEHLVDRGRRRIATIAGPQDMGVGIDRLTGYRAALAEAGLPELVV
                     HGDFSEASGIAAAEELLARDPGLDAIFAADDPMALGAMRVLRRHGRAVPADVAVVGFED
                     SPSAALSDPPLTTVHQSAEEMGREMTRLLLARINGERLDEPVVILPPHLVVRASS"
     CDS             complement(8940..9161)
                     /gene="allorf_410874_411095"
                     /locus_tag="allorf_410874_411095"
                     /protein_id="allorf_410874_411095"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSISVGLSGGFQPGSPWPCARLTTPNDTGEGVGGRGFYRAQRRLP
                     CELSSNSRTCGSERLGPIYRGPGAHMRR"
     CDS_motif       complement(9132..9161)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSISVGLSGG"
                     /locus_tag="allorf_410874_411095_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(8940..9131)
                     /prepeptide="core"
                     /locus_tag="allorf_410874_411095_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="6757.5"
                     /monoisotopic_mass="6753.4"
                     /core_sequence="FQPGSPWPCARLTTPNDTGEGVGGRGFYRAQRRLPCELSSNSR
                     TCGSERLGPIYRGPGAHMRR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSISVGLSGG"
                     /leader_location="[9131:9161](-)"
                     /alternative_weights="6775.5"
                     /alternative_weights="6793.6"
                     /alternative_weights="6811.6"
                     /alternative_weights="6829.6"
                     /alternative_weights="6847.6"
                     /alternative_weights="6865.6"
     misc_feature    9008..9022
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.76"
                     /tool="antismash"
     gene            9184..9579
                     /locus_tag="P696_RS0120025"
     CDS             9184..9579
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039929.3"
                     /locus_tag="P696_RS0120025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DurN family substrate-assisted peptide maturase"
                     /protein_id="WP_157429812.1"
                     /transl_table=11
                     /translation="MWSTGPKPPSDVTKHKNIYTVRQIQHLLVLCSLLKQDGPLARTLA
                     NALALDPLPMAVRAEPVPSVHPQATKDWLESFWEPAALTPDEVEVAAWQNNITEMVTAV
                     EEIHAIEKLIGIRLTTEIMTQPEENSQ"
     gene            9603..9842
                     /locus_tag="P696_RS0120030"
     CDS             9603..9842
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_026413721.1"
                     /locus_tag="P696_RS0120030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cinnamycin family lantibiotic"
                     /protein_id="WP_026413721.1"
                     /transl_table=11
                     /translation="MTATSILRHAAADADFRSELLERPTDFGVTAVPAGVEQPDAEQLG
                     YWTEGVAAVDIYACSSTCSFGPFTIVCDGTTKGQ"
     CDS_motif       9603..9707
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTATSILRHAAADADFRSELLERPTDFGVTAVPAG"
                     /locus_tag="P696_RS0120030_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9708..9842
                     /prepeptide="core"
                     /locus_tag="P696_RS0120030_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="4501.9"
                     /monoisotopic_mass="4499.1"
                     /core_sequence="VEQPDAEQLGYWTEGVAAVDIYACSSTCSFGPFTIVCDGTTKG
                     Q"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTATSILRHAAADADFRSELLERPTDFGVTAVPAG"
                     /leader_location="[9602:9707](+)"
                     /alternative_weights="4519.9"
                     /alternative_weights="4537.9"
                     /alternative_weights="4556.0"
                     /alternative_weights="4574.0"
                     /alternative_weights="4592.0"
     gene            10001..13189
                     /locus_tag="P696_RS0120035"
     CDS             10001..13189
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="P696_RS0120035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_034485789.1"
                     /sec_met_domain="DUF4135 (E-value: 3.7e-63, bitscore:
                     208.5, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2e-56, bitscore:
                     185.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHRLDLAARAANLAERRRVVDALGPPQDPPALSEFDTWMAARQA
                     GKLAERGAQSKRRDLPGRDDHEHDDLVALLTAYRQNELLLASADSPVGRLLEELAADWL
                     PTYRAALDGPRDDAASGPDAWWRAPEVLYGGHAILCAPFLAELDRRLTAILAEDDGGPV
                     FDRGFVTGFQERLLSRFGLAMAWAVETDAKAYCAQHGIDPEAASEADFTAHLDGTFGDA
                     EDHHRFFLDFPVLGRWLAHVTDLLTGHGRDLVTRLRADAADVGAAFYGTPVTAVRGATL
                     GHGDDHAGGRSVVILAVETADGPEKLVYKPRSVHGEAALQGLLDRMRTDGALGFASRPV
                     LPRDGYGYEAFIPSGRNHVADRAAAAAVHAELGGYLALFYVLGGGDLHFENILVADGHA
                     FICDGETILGAVPGERPDGAGTVMDSVFRTGLIEWPSGRADAEGSMRLSGYAGGGAYEM
                     PTSVPQLDDRGPSFAASVRHVSGVLVDPGANNRVFVDGEITHAEDFAEDVGAGFDAVYQ
                     WFARGGEDAVKIVRELFGGARVRFVNWSTQIYAQLLLASRHPRCLMDPIEVDLLVDTVR
                     HFPRVWDHDLACPDREAESMWRMDIPLFDTPADADRVTHDHGEAVPVRLAAAPLDIAAE
                     RIMALTEENRRRQRQYISAGLAGGDVTSEDFAATCLEQAEAVAERLCAAARVTGAPWTS
                     YIVTKDGHEEVDIEADLYNGTAGIALFLAHLNDLRPRPEFERTARLALAHAVEHTDMSR
                     LGAYPGIGGLIYTLLHLHRLWDERELLDQAVALADGLAPAIEQDDRLDVYFGVAGLIPV
                     LIQLAETTGGHGAGLAIRCAEHLLKTANTDGDAMSWPGDDGGAALADLTGFAHGAGGVG
                     WALAMLGKRTGRNAYVDAARRAFAYEDRHFDELVQDWYDLRSSPGGPIWNDRHFANAWC
                     NGSAGIGLARLATWDVLGREDEDMVRGATRGLTATVRNFPRLMNDTLCHGRSGNAELLL
                     RHALLREEPAFRVEANLHAQNQWRNLAEARTGPESGFFPGLMLGMAGFGMHFLRLARPE
                     RIPSVLLLDPPTRP"
     gene            13196..14092
                     /locus_tag="P696_RS0120040"
     CDS             13196..14092
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03798"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019631330.1"
                     /locus_tag="P696_RS0120040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Nif11-like leader peptide family natural product
                     precursor"
                     /protein_id="WP_245627733.1"
                     /sec_met_domain="TIGR03798 (E-value: 2.6e-08, bitscore:
                     28.6, seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSMSVDACQEFMTAAGTDPDLALRMRAMTGVPELLRLARDHGYE
                     FTVPDLAAVSMASARESGEPGRPPAAAGPAAETSVLHSEYALGDLPGFAEVLDLLPLVK
                     IRPPSVDMDRFADAFDPADLASTGFAPSGPEYRRWRAGVRTAPGDRRDFHLVNLDDHVT
                     HPGYESYLDAKVRLVGALEKVFGPEVRFSGSMWYPPSSYRLWHTNKDQPGWRMYLIDFD
                     DDFDDPSDTSFFRYQTPGTGELVTLRERPRMARFFKIEQEPERLFWHCIVNPTERHRWS
                     FGFVVPDHWKAALEAAA"
     gene            14089..15774
                     /locus_tag="P696_RS59090"
     CDS             14089..15774
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="P696_RS59090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_051467904.1"
                     /transl_table=11
                     /translation="MTAPPALPDAADAAGPAGIPPAIAASGLRKRYGDVVAVDGVDLSV
                     EAGECFAFLGPNGAGKSTTISMLCALTRPTAGRVAIAGHDTLADPLEARRRIGLVFQES
                     TLDLGLTAAENLRFHADLYDVPPGLIPERVDRALDLVGLTAERDRIVGTFSGGMRRRLE
                     IARALLHRPRLIVLDEPTLGLDPHARARVWEHLRAVREREAVTIFLTTHYLDEAEQCDR
                     VAIIDAGRIVAQGSPAALKAELTAPGAPPPSLDEVFLHHTGRPLHDDTELGEPPAAAPP
                     PVRPEDMSLPPARRPAAEFRAVRMVWRRDLLIYRRDGGGALLAMAQPLLFLFILGVGLS
                     GLMPGIGQGTYQLFVFSGALVTAALGPAVAVGASLLWEKQAGFLREMLAGPVRRESLLL
                     GKCLGGATIATVQGTLLLAAGPLIGVPAKPQLIVMLAGQLALTSLAMTACGVLAATFVR
                     RPPTYGTAMSVLVAPLTFLSGAMFPLAGLPAWLRALALADPLTYAVDALRRTVASQLPS
                     APPHLFRPLAIGGWHPPIVAEWTLLALLALVPLLWSAHRFSRAD"
     gene            15873..16295
                     /locus_tag="P696_RS52675"
     CDS             15873..16295
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040404.3"
                     /locus_tag="P696_RS52675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_051467905.1"
                     /transl_table=11
                     /translation="MEARIKVSGDDPARETAGLHEWLRGDRTLAGRVRAESTPPRDGEL
                     GGSADVLVAALGSGGAAVALTNVLVAWVKSRRPDVSVTVTTENGSVKIDTTDLPADAVL
                     PLLREVLHGDEHRRDLIRRDDAALRDGDKALRDGDD"
     gene            16288..18090
                     /locus_tag="P696_RS52680"
     CDS             16288..18090
                     /GO_function="GO:0004197 - cysteine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012862.4"
                     /locus_tag="P696_RS52680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="caspase family protein"
                     /protein_id="WP_051467906.1"
                     /transl_table=11
                     /translation="MTDFSRSRAVLVGTAEYADAAFPRLPAAANSLAGMRAVLTDPSLC
                     GWPDDRVTVESDPSDWRGLVRRTRVLARETEDVLLLYFVGHGVMLPRGELSLALTDTEA
                     DDPDLTGLEYRRVRDLLRDSPAATKIVILDCCYSGRAIEALTALDAVADSTDVRGVYTL
                     TASDHTAHVVPLAEQEAVPTSFTGQFLALVRDGVRDGPESLTLGDLYVHLRRRLTAHGL
                     PAPNQRGTDTADRYPFTRNPAHRRPPPPYPYPRSRPEPGVVARPRLFPAEPRGLWSTIP
                     GVPALLPQETVGASALAFSPDGRSLVTGHLDGSVHLRRWSFEGSTPLRPVAGESGPISA
                     VAVTSVGPLVAYAVPGQEVGLYSLESSGPEHRLLADSWSCPKGPVRTLAFTPDGRWLVA
                     GQATTKEDSRTCVVWNVRTGGRLRDPEPAKDSWALWWHASDHAVTILPDGRVLTLQHRD
                     GHNAVATYRLAGGQPTKILESRVEIGFVHGVEAAGISPDGRTIVTVEHGRIHYWRATDD
                     GHLDGPTFAEGTPATSVVVGPEGRAAALWAPGEPLRVWDLHAFEQIGGSLQHSGQTRAV
                     AFTPDGATLAVGDAEWPVRLWRPA"
     gene            complement(18113..18736)
                     /locus_tag="P696_RS46855"
     CDS             complement(18113..18736)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570322.1"
                     /locus_tag="P696_RS46855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_051467926.1"
                     /transl_table=11
                     /translation="MRRTGLVDQIREFIVDGISSGRWQPGERIVERRVATELGVSQGPV
                     REALRLLETLRLIETLPNRGARVRPFDERDLAEIFPVRAGLERTAVELALPSLTAHLDE
                     LEEQNARLAEAATAGDLDEQIRESIHFHRLVVGFSGNQLLTSVWEGLGIEVWTTLSLRL
                     HKTEIYSKSAEHARIIEAFRQQDPAAPQMLHDHVMNYAPLTYRP"
     misc_feature    complement(18804..18815)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    complement(18845..18860)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.18"
                     /tool="antismash"
     gene            18960..20099
                     /gene="pdhA"
                     /locus_tag="P696_RS0120065"
     CDS             18960..20099
                     /EC_number="1.2.4.1"
                     /GO_component="GO:0045250 - cytosolic pyruvate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0004739 - pyruvate dehydrogenase
                     (acetyl-transferring) activity [Evidence IEA]"
                     /GO_process="GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /gene="pdhA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620482.1"
                     /locus_tag="P696_RS0120065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate dehydrogenase (acetyl-transferring) E1
                     component subunit alpha"
                     /protein_id="WP_026413724.1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-09, bitscore:
                     32.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAETTKAAPGRARRTPGPTSTRGTAAKGTPKAADNRASAVARRRA
                     DDEARVEYFRQMLLVRRFEERTARAYTEAKIGGYCHLNLGEEATVVGLMAALRPTDYLF
                     TNYREHGYAIAKGIEPRRVMAELYGRSTGVSKGWGGSMHMFDTEARLLGGYGIVGGQLP
                     LATGAAMAVSYRGGDDVVMVQMGEGTAAIGAFHESLNIAALWNLPVVFVIINNGLGMGT
                     TVEHSAAEPELYKRGAAYRMASMRVDGTDVIAVRDAAREAVERAREENRPYLLECTSPR
                     LRGHSVVDPAKYRTKEEKEALKAADPLAKAQLELQEEGLLSVEDIERLEAEIAEIVTDA
                     ATFADESPHPEVSTLFDYTYATPVPNDLPRLPADPLFRV"
     gene            20113..21129
                     /locus_tag="P696_RS0120070"
     CDS             20113..21129
                     /EC_number="1.2.4.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155796.1"
                     /locus_tag="P696_RS0120070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha-ketoacid dehydrogenase subunit beta"
                     /protein_id="WP_026413725.1"
                     /transl_table=11
                     /translation="MATITYRQALRDTLRAEMLRDENVLLMGEEIGVFEGSYKITEGLL
                     KEFGERRVRDTPIAEEGFVGAAIGAAMLGLRPVVELMTINFSLLALDQIVNHAAKIYGM
                     FGGQKPVPMVIRTPGGGGQQLGATHSQNVELYYSFVPGLKVVAPSTPLEASALLKAAIR
                     DDDPVLFLENLALYNTKGEVPDDIADVQPAEIGRAAVTREGTDITIIGYSRMAHVASEV
                     AERLAAEGVSAEVVDLRSLRPLDRETIVASVRKTGSAVVAEDDWLTYGIGAEIAATIQE
                     GAFDWLDAPVRRVAMAEVPLPYSKPLETAALPSADSLLTAVRETLRATGRPTLETVR"
     gene            21126..22403
                     /locus_tag="P696_RS0120075"
     CDS             21126..22403
                     /EC_number="2.3.1.-"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019609479.1"
                     /locus_tag="P696_RS0120075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrolipoamide acetyltransferase family
                     protein"
                     /protein_id="WP_026413726.1"
                     /transl_table=11
                     /translation="MTEILMPRLSDTMEEGVIAAWQKKPGDEVAVGDVLCEIETDKAVM
                     EYEAYEAGVLTEILVAEGETAAIGAPIAIIGGKGDAPVTTEAKAEAPAAEPAPAAEPEP
                     AKVPALVGAERPSSNGVSGTRPPSSPLARRLARDHGLDLHTITGTGPGGRIIRADIEAA
                     IRGGAQPAAAPAPAPAAPAPAAASAPKPAAPQVADEDVERVPLNRFRKVAARRLVESKQ
                     NAPHFYLNRDVDAEALVAFRGTLNEALAPVKVSVNDLIVKASARALREHPQVNTSYTED
                     ALLVHKRVHVGVAVAVADGLLVPVIKDADRKSVSQIGAETRELAAKARDGKLSPAEMSG
                     GTFSVSNLGMFGVDSFSAVINPPEAAILAVGAVRAEPVVKDGQVVPGQRMTITLSVDHR
                     AADGATGARFLDRLAQLLENPLLIVA"
     gene            complement(22679..22891)
                     /locus_tag="P696_RS0120080"
     CDS             complement(22679..22891)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017547177.1"
                     /locus_tag="P696_RS0120080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_026413727.1"
                     /transl_table=11
                     /translation="MRISSVVLLLWLVIGAVAAGQRHYYDRPVKDQVKDCSRSGTIAVT
                     VVAGPLNYLGVNPKISCKDLPEPSK"
     CDS_motif       complement(22745..22891)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRISSVVLLLWLVIGAVAAGQRHYYDRPVKDQVKDCSRSGTIAVTVVAG"
                     /locus_tag="P696_RS0120080_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(22679..22744)
                     /prepeptide="core"
                     /locus_tag="P696_RS0120080_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="2276.6"
                     /monoisotopic_mass="2275.2"
                     /core_sequence="PLNYLGVNPKISCKDLPEPSK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRISSVVLLLWLVIGAVAAGQRHYYDRPVKDQVKDCSRSGT
                     IAVTVVAG"
                     /leader_location="[22744:22891](-)"
                     /alternative_weights="2294.7"
ORIGIN
        1 atggtggacg gctgcacccg cggccaggcc ttccggaaga tcatcgtccc gctggccgcg
       61 ccgggcgtgt tcaccaccgc gatcctgacc ttcatcgcgg cgtggaacga gttcctcatc
      121 gccctgtcga tggtcaaccg caaggagatg cagaccgcga cggtcgcgat ctccaagttc
      181 accggcgtgt ccggcttcga ccagccgttc ggcacgcaga tggcggcggg cgtggtcgtg
      241 accgtcccgc tcatcgtcgt cgtgctcgtg ttccagcgcc ggatcgtcgc gggcctcacg
      301 gcaggcagcg tgaagtgacc cgccggaacg ccccccgcac gaacgtttga cccggcttca
      361 cgtgacccga agggatgaca tgaccgacac gccgaccacc gcctggtggc gggacgcggt
      421 gatctaccag gtgtacgtgc gcagcttcgc ggacgccagc ggcgacggca tcggcgacct
      481 ggcgggcatc cgctcccggc tgccgtacct ggccgacctg ggcgtggacg cgctgtgggt
      541 caccccgttc tacgtctcgc cgatggccga cttcggctac gacgtggccg actaccggga
      601 cgtggacccg ctgttcggca ccctggacga cgcgcgctcc ctcatcgcgg acgcgcacgc
      661 gcacgacctg cgcgtcatcg tcgacgtcgt gccgaaccac agctccgacc accacccgtg
      721 gttccgggcc gccctcgccg ccgcgcccgg ctcgcccgag cgcgagcggt acctcttccg
      781 cgacggacgc ggcgcggacg gctccgagcc gccgaacgac tgggagtcgg tcttcggcgg
      841 cccggcgtgg acgcgcgtgc cggacggcca gtggtacctg cacctgttcg cgcccgagca
      901 gcccgacctg aactgggaga accccggcgt ccgcgccgag ttcgaggaca tcctgcgctt
      961 ctggctcgac ctcggcgtgg acggcttccg gatcgacgtc gcccacggca tggtcaaggc
     1021 cgccgggctc cccgacgtcg gccacaccgg ccagtccgag atgctcggca cggccgtcct
     1081 gccctacttc gaccaggacg gcgtccacga gatccaccgc gcgtggcgca agctgctcga
     1141 ctcctacccg ggcgagcgga tcggcgtcgc cgaggcgtgg gcgccggaca ccgcgcggct
     1201 cgcgaggtac acccgcccgg acgagctgca ccaggcgttc aacttccact acctgggctc
     1261 gccgtgggac gcggcgaagc tccgcgacgt catcgacggg accctgcgcg ccgcgggcgc
     1321 cgcgcccgcg acgtgggtgc tgtcgaacca cgacgtcaag cggcacgtca cccggttcgg
     1381 cggcggcgag accggcctgc gccgcgcccg cgccgccgcg ctgctcacac tcgcgctgcc
     1441 cggctccgcc tacgtctacc agggcgagga gctcggcctg cccgaggtgc tcgacctgcc
     1501 cgccgagttc cgcagggacc cgcaggccgg acgcggcgag gacgcgggcc gcgacggctg
     1561 ccgcgtgccg atcccgtgga acggcgacga gccgcccttc gggttcaccg ccgggccgtc
     1621 cacgtggctg ccgatgccgc ccgaatggcg cgcgctgacc gtcgccgccg aggaggccga
     1681 cccggactcg acgctcgcgc tgtacaagac ggcgctgcgg atccggcgcg ccgagcgggc
     1741 gctcggcgac ggcgccctcg cctggctgga cgtcccggac ggcgccctcg ccttcacccg
     1801 gcgggccgcg gacggcacgt ccgtcggctg cgcggtcaac accggcgccg agcccgtgcg
     1861 cgtccccgcc accggcgaga cgctgctgtc cagcgcaccc gtgacgcgcg aggccgacgg
     1921 caccctcgtc ctgccgcccg acacgaccgc ctggtggagg taaattcgtg gccatgacga
     1981 cgccgacgcg cctggccgac atcgccgagc acgcgggggt cagcgaggcg acggtcagcc
     2041 gcgtcctcaa cggccgcccc ggagtgtcgg cgacgacccg gcagtcggtg ctcgccgcgc
     2101 tggacgtcct cgggtacgag cgtccggcgc ggctgcggca gcagcgcgcc gggctgatcg
     2161 ggctgatcat cccggagctg accaacccga tcttcccggc gttcgccgag atcatcgaga
     2221 gcgcgctggc ccggcacggc tacatggccg tgctgtgctc gcagaccccc ggcggcgtgg
     2281 ccgaggacga ctacctggag atgctgctgg agcgcggcgt cgcgggcgtc atcttcgtca
     2341 acggcctgca cgccaacgcc aactccgacc gggcgcggta cgcgcggctg accgagcagg
     2401 gcctgccgat cgtgctggtc aacgggcacc gtccggacat cgacgcgccg ttcgtctcca
     2461 acgacgacgt cgcgtcgctg gaggcggccg tcgcgcacct gggctcgctc gggcaccggc
     2521 ggatcggcct ggcgatcggg caggacgtgt acgtcccgac ccggcgcaag accgaggggt
     2581 tccggcgcgg cctcgcgacg ctgctcgggc cgtccgcgga caccgagggc ctggtcgtga
     2641 acacgatgta caccgtcgag ggcgggcagg ccgccgcgca gaagctgctc gaccgcggct
     2701 gcacggcgat ctgctgcggc aacgacatca tggcgctcgg cgcgatccgg gccgtccggc
     2761 agcgcgggct gcgggtgccg gaggacgtgt cggtcgtcgg cttcgacgac tcgccgctca
     2821 ccgcgtacct ggacccgccg ctcaccacga tccggcagtc ggtgcgggag atggcgctgg
     2881 ccgcggtgag cacggtgctg gaggaggtcg ggggcggacg tccgccgcgc accgagctgc
     2941 tctaccgtcc cgagctggtc gtccgccggt cgacggcgcc cgcgccggtc ccggccgccc
     3001 cggcgcccac cagccctgag cacctcgtca actaatcccg ggcacctcgc cgaccagccc
     3061 ccgggccggt cggcgaccgg ctctgggcag ctcgccgaac gccccgatcc tccgagatcg
     3121 gggcgttctc gttgataacg gttgcgttgc ggaggattga cagtgagccg ggtcacgttc
     3181 tttgcttcgt gggagcgctc ccacactccc acccacgaac gaacgagagg gacccacatg
     3241 aggggttacc ggctgaggac cgtggccgtg ctggcgacgg ccggcgtgct cgcggcggca
     3301 tgcggaggcg gaggcgacga ctccaagtcc ggcaagaact tcacgctgac cgtcgacgtg
     3361 ttcggcgagt tcggctacga gaacctctac aaggggttcg agcaggcgca ccccggcgtc
     3421 acggtcaagc agcgcaaggt gtcgtcgctg gacgactaca agccgcggat ccagcagtgg
     3481 atcgccaccg gcagcggcgc gggcgacgtg gtcgcgctgg aggagggcat cctgcccacc
     3541 tacatgcagc agcgctccaa gttcgtcaac ctcttcgact tcggggcccg ctcgatgcgg
     3601 ggcgacttcc tgccgtggaa gtggcagagc ggcctcagcc cggacgggag tcagctcgtc
     3661 gggctcggca ccgacgtcgg cccgctcgcc atgtgctacc gcaaggacct gttcaagaag
     3721 gccgggctgc ccagcgagcg cgacgaggtc ggcaagctct ggccgacctg ggaccagttc
     3781 ctcgcgaccg gccagaagtt ccagggcaag gtgtccggca ccaagtggct ggacggcccg
     3841 accgccgtcc tgcgcgcgac cgtcctgcag aacgcgggca gcggccccgg ctacagcttc
     3901 ttcgacaagg acgacacgtt cgtcttcgac accaacccgg ccgtgaagca ggcgttcgac
     3961 acgacgctga agttcgagca gaacaagatg acctcggaca tgtcgatctt cacgccgccg
     4021 tggcagacgg cgctgaagcg cgacacgttc gcgaccgtgc cctgcccgtc ctggatgctc
     4081 ggcggcatca agcagttctc cggcgacttc ggcaagggca agtgggacgt cgcgaccacg
     4141 ccgggcgggt cgggctactg gggcgggtcc tggctggccg tcccgaagca gagcaggcac
     4201 cagaaggagg ccgccgccct cgcccagtac ctgaccggga cgcagagcca ggtcggcgcg
     4261 ttcaaggaca aggacacctt cccgtccaac gtgaaggccg agcaggaccc ggccgtgtcc
     4321 ggcgcgacca acgactactt cagcggcgcg ccgaccggga agatcttcgg gcagctggtg
     4381 tcctcggtga agcccgtcca cctcggcccg aagaacgagg acgtccggca ggcggtggag
     4441 aacgtcctga tcgcggtggg ccagggcaag gtcaagcccg aggatgcctg ggcgaaggcc
     4501 gtcgacgcgg ccaagaaggc cgcgcggtga ccttcatgga cacgggtcgg tccgcggcgc
     4561 tcccccggtg gtgggggacc cgatgaccag tgtggacacg cgtcccgtcc gtccgtcctc
     4621 gcgggcggac ggggcgccgc gggcgagccg gtggcgggcc cggctcgacc gcctcgacct
     4681 caaggcgagc ccgtacctgt tcgtcgcgcc gttcttcgtc gtcttcctcg tcttcggcgg
     4741 ctacccgctc gtctacacgc tgtgggtgtc gctgcacgac tgggggctgt cgtcggggac
     4801 gcgcgagtgg gcgggcttcg ggaactacgg ctacctgttc ggcgacgacc agttctggca
     4861 cgcgctggtg aacacggtgg ggatcttcgt gctctcgacc gtcccgcagc tgctgctggc
     4921 gctgctgctc gccaacaccc tcaaccggcg gatgcgcggc gcgacggtgt tccggatcgg
     4981 ggtggtcgcc ccgctgatca cctcgatggc ggcggtcgcg atcgtgttcg gccagctgtt
     5041 cgacaccgac tacgggttcg tcaactggct cctgcaaagc cacatcgact ggcacgcgag
     5101 ccgcgcctgg tcgtggacgg cgatctcggt gatggtcgac tggcgctgga cgggctacaa
     5161 cgcgctgatc ttcctggccg cgatgcaggc gatcccgaag gacctgtacg aggccgccgc
     5221 gatcgacggc gcgtcccgga tgcggcagtt ctggcagatc acggtcccgc tgctgcgccc
     5281 gacgatcctg ttcacggtga tcatctcgac catcggcggg ctgcagctgt tcaccgagcc
     5341 ggtgctgttc ggcggcgcga cgtccaacaa gatggacggc ggcgcgacgc accagttcca
     5401 gacgctgacg atgtacatgt acgacaacgc gttcggccac gaccggtacg ggtacggcgc
     5461 ggcgatcgcc tgggcgctgt tcctgctcat catcgcgttc tccctgctga acttcctgtt
     5521 cgtccggcgt gcgggaggca ccagatgacg atccccgctc ccctgtcccg gcccgcgcgg
     5581 tcgaccgcgc ggcggctgca cggcctctgg gaggccagcc cgctgacgta cctgacgctg
     5641 ctggtcgcgg tggtgctgtc ggtggcgccg atctactgga tgttcgtggt cgcgacgcgc
     5701 accaacgacg tggtcgcgaa cgtcccgccg ccggtggtgc cgggcggcca cctcgggtcc
     5761 aacctgaacc ggctgttcga caacccggac gcctacttcg ccaagggcct gctgaactcg
     5821 ttcgtcgtgg cgtcctgcgt gacggtctcg acggtgttct tcgcctcgct ggccgggttc
     5881 gcgttcgcca agctgcgctt ccgcgggcgc aacgcgctgc tgctgacgat cgtggcgacg
     5941 atgatgatcc cggtccagat gggcatcatc ccgctctaca tgatcatggt gcggctgggc
     6001 tggcagaacc atctgcagtc ggtgatcgtc ccgttcctgg tcaccgggtt cggggtgttc
     6061 atgatgcggc agtacgccgc ccaggccgtc ccggacgagc tgatcgaggc cgcccgcgtg
     6121 gacggctgca ccaccttcgg cgtgtactgg cgggtcgtcc tgcccgcgct gcgcccggcg
     6181 gcgggcgtgc tcggcctgtt caccttcatg cagacctgga acgacttcat gtggccgctg
     6241 gcggtgctga acccggagaa cccgaccgtc cagctgtcca tcaacaacct ggccaacggc
     6301 cacttcaacg actacacgct catgttcgcc ggcacgacgg tcgcggtgct gccgctgctg
     6361 ctggtcttcg tggcgttcgg ccgccagatc atcggaggaa tcatggaagg cgcggtcaag
     6421 gcatgagcgg gaagggcgct aacggccagg gcacgagcaa gcagggcacg agcgcgcgcg
     6481 tggacttccc ggacgggttc cggtgggggg cggcgacggc cgcctaccag gtggaggggg
     6541 ccaccgacgc cgacggcagg gtgccgtcga tctgggacac cttcgtgcgg cggcccggcg
     6601 cggtgctggg cggcgacacc ggggacgtgg cggtcgacca gtaccaccgg ttccgcgagg
     6661 acgtggcgat catgcgcaac ctcgggctca ccgcgtaccg gttctcggtg gcgtggcccc
     6721 gcgcggaggc gcccggcggc cggggcctcg ggttctacga gcggctcgtg gacgcgctgc
     6781 tggacgcggg gatcgagccc tggccgaccc tgtaccactg ggacctgccg cagtcgttgg
     6841 aggacgcggg cggctggccc gttcgcgaca ccgcgcaccg gttcgccgac tacgcggccc
     6901 gggtgcacct cgtcctcggc gaccgggtga ggaactggct gacggtgaac gagccgtggt
     6961 gcgcggcctt cctggggtac gcgtccggcg accacgctcc cggacggcgc gaaccggggg
     7021 ccgcgctgtc cgccgcgcac cacctgatgc tcgggcacgg cctggccgtc caggcgatgc
     7081 gcgcggagcg gccggacaac aggttcggcg cggccgtgaa cctgtacgcg atctcgcccg
     7141 cgtcggacgc ggaggccgac gtggacgccg cgcgccgcgt ggacggcctc cagaaccggt
     7201 tcttcctgga tccgctgctg ctcggccgct accccgagga cgtcctggcg gacgtggagc
     7261 ggttcgggtt cgcgccgccg gacgccgacc tcgcggtcat caaccagccg atcgaccacc
     7321 tcggcgtcaa ctactactcg cggcacaccg tcagcggcga tccggactcg gccccgcagg
     7381 cggcggcgtc cccgttcgcc gagcattcgc cgtgggtggg cagcgggcac gtgcggttcc
     7441 cgtccaccgg acggccggtg accgggatgg gctgggagat cgacccgtcc gggctgacgg
     7501 acgtgctggt caggctgcac gaggagtacc cggcggtgga cctgtgcgtc accgagaacg
     7561 gggcgggcta ccaggaggag ccgtccaacg gaacggtcca cgacgccgag cgcatcgcgt
     7621 acctggacgg ccatctccgc gcctgccatg acgcgatctc cgcgggtgtc ccgcttcgcg
     7681 gctacttcac gtggtcgctg ctggataatt tcgagtgggc gtgggggtac tcacggcgct
     7741 tcgggctggt ccacgtcgac tacgccacct tgcgccgcgc gcccaaggac agcgcgcgct
     7801 ggtacgcgga ggtgatccgc cggggcgggc tcggggaccg cgggtaacgg ggaaacggga
     7861 gggcgggcgg gatggccgga cggggaacac gtcccaccct ggaggaggtc gccgcgctgg
     7921 cgggcgtcgg ccgcggcacc gtctcccggg tgatcaacgg ctcgccgcgg gtcagctccc
     7981 gcgcgcggga cgcggtgctc gcggcgatcg acgagctcgg gtacgtgccg aaccgggccg
     8041 cccgcacgct ggtcacccgg cgcaccgaga cggtcgcgct ggtcgtcgcc gagtccgagc
     8101 tgcggctgtt cgacgagccg ttcttcgcgg gcatgatccg cggcgtcagc gcggcgctga
     8161 acgagaccgg cctgcagctg ctgctcgccc tcgcccgctc ccccgccgag tacgagcggc
     8221 tggagcagta cctcaccgcc cagcacgtgg acggcgtgct gctcacctcg ctgcacgccg
     8281 aggacccgct gcccggacgg ctggaggcga gcggcgtgcc gaccgtcctc ggcggccgtc
     8341 cgcccggcat cgagccggtg tcgtacgtgg acgtcgacaa ccgcagcggc gcgcggcagg
     8401 ccgtcgagca cctggtcgac cggggccgcc gccgcatcgc caccatcgcc gggcctcagg
     8461 acatgggcgt cggcatcgac cggctgaccg gctaccgcgc cgcgctcgcc gaggccgggc
     8521 tgcccgagct ggtcgtgcac ggcgacttca gcgaggccag cgggatcgcg gcggccgagg
     8581 agctgctcgc gcgcgacccg ggcctggacg cgatcttcgc ggcggacgac ccgatggcgc
     8641 tcggcgcgat gcgggtgctg cggcggcacg gacgggccgt cccggcggac gtggcggtcg
     8701 tcggcttcga ggactcgccg tccgcggccc tctccgaccc gccgctcacc accgtgcacc
     8761 agtcggccga ggagatgggc cgcgagatga cccggctgct cctggcccgg atcaacggcg
     8821 agcggctgga cgagccggtc gtcatcctcc cgccccacct ggtcgtccgc gcctccagct
     8881 gacgcgtccc ctcccgacgc gtccgcgcgg agtgccgccc gcgttccggc acccctcgct
     8941 cacctgcgca tatgcgcgcc agggccccga taaatcggtc ccaacctctc agacccgcag
     9001 gtccgtgaat tgctcgacaa ttcacagggc aaacgtcgtt gcgcgcgata aaaccctcgc
     9061 ccacccaccc cttcacccgt gtcatttggc gttgttaacc tggcgcacgg ccagggagaa
     9121 ccgggctgga aaccgccgga aagaccgacg gaaatggaca ccggcagacc acggggagac
     9181 gcgatgtgga gcaccgggcc gaagccgccc agcgacgtca ccaagcacaa gaacatctac
     9241 accgtccggc agatccagca cctgctggtg ctgtgctcgc tgctcaagca ggacgggccg
     9301 ctggccagga cgctggccaa cgcgctggcg ctcgaccccc tccccatggc cgtgcgcgcg
     9361 gaaccggtgc cgagcgtgca cccccaggcc accaaggact ggctggagtc cttctgggag
     9421 ccggccgccc tgacccccga cgaagtggag gtggccgcct ggcagaacaa catcaccgag
     9481 atggtgaccg ccgtggagga gatccacgcg atcgagaagc tcattggaat tcggctgacc
     9541 accgaaatca tgacccagcc ggaagagaac tcgcagtaat gcgaatcacc aaggaggaag
     9601 aaatgaccgc tacctcgatt cttcgtcacg ccgccgccga cgccgacttc cgcagcgaac
     9661 tgctcgagcg ccccaccgac ttcggcgtga ccgcggtccc cgcgggcgtc gagcagcccg
     9721 acgccgagca gctgggctac tggaccgagg gcgtcgcggc cgtggacatc tacgcctgct
     9781 cctcgacctg cagcttcggt ccgttcacga tcgtctgcga cggcaccacc aagggccagt
     9841 aagtgcctgc ccggcgcgtc cgaggtgagg cgccgggccc tctccccacg gcccccggtc
     9901 cgtctgcggg gtcgagtgtg acgacggtgg gccggccgag gccggcccac cgtccctcac
     9961 cttttcccgc ccgtcccctt ccgaggagca cccgtccgtg atgcagcacc gcctcgacct
    10021 cgcagcccgc gccgccaacc tggccgaacg gcggcgggtg gtggacgcgc tcggcccgcc
    10081 gcaggacccg cccgccctca gcgagttcga cacctggatg gccgcacggc aggcaggcaa
    10141 gctcgccgag cgcggcgccc agtcgaaacg gcgtgacctg cccggacgcg acgaccacga
    10201 acacgacgac ctggtcgctc tcctgacggc ctaccggcag aacgagctgc tcctcgcctc
    10261 cgccgactcg cccgtcggcc ggttgctgga ggagctggcc gccgactggc tgcccaccta
    10321 ccgcgccgcg ctcgacggcc cgcgcgacga cgccgcgtcc ggcccggacg cctggtggcg
    10381 cgcgcccgag gtgctgtacg gcgggcacgc gatcctctgc gcgcccttcc tcgccgagct
    10441 cgaccgccgc ctcaccgcga tcctcgccga ggacgacggc gggccggtgt tcgaccgggg
    10501 gttcgtgacc gggttccagg agcggctgct cagccggttc ggcctggcca tggcctgggc
    10561 ggtcgagacc gacgcgaagg cgtactgcgc gcagcacggc atcgacccgg aggccgcgtc
    10621 cgaggccgac ttcaccgcgc atctggacgg cacgttcggg gacgccgagg accaccaccg
    10681 cttcttcctc gacttccccg tcctcgggcg ctggctcgcg cacgtgaccg acctgctcac
    10741 cgggcacggc cgcgacctgg tcacgcggct gcgcgccgac gcggcggacg tcggcgccgc
    10801 cttctacggc acgccggtca cggcggtgcg gggcgcgacg ctcggacacg gcgacgacca
    10861 cgccggcgga cgcagcgtgg tgatcctcgc cgtcgagacg gcggacggtc ccgagaagct
    10921 cgtctacaag ccgcgcagcg tccacggcga ggccgcgctc cagggcctcc tggaccggat
    10981 gcgcaccgac ggcgcgctcg gtttcgcctc ccggcccgtc ctgccgcggg acggctacgg
    11041 ctacgaggcg ttcatcccgt ccgggcgcaa ccacgtcgcg gaccgcgccg cggcggcggc
    11101 cgtgcacgcc gagctcggcg gctacctggc gctgttctac gtgctcggcg gcggcgacct
    11161 gcacttcgag aacatcctgg tcgcggacgg gcacgcgttc atctgcgacg gcgagacgat
    11221 cctcggggcc gtccccggcg agcgtccgga cggggcgggc accgtgatgg actcggtgtt
    11281 ccggaccggc ctgatcgagt ggccgtccgg acgcgccgac gccgagggct cgatgcggct
    11341 gtcgggctac gcgggcggcg gcgcgtacga gatgccgacc agcgtcccgc agctggacga
    11401 ccggggcccg tcgttcgccg cgtccgtccg gcacgtgtcg ggcgtgctgg tcgatccggg
    11461 cgcgaacaac cgggtgttcg tcgacggcga gatcacccac gccgaggact tcgccgagga
    11521 cgtcggcgcc gggttcgacg cggtctacca gtggttcgcc cggggcggcg aggacgcggt
    11581 caagatcgtg cgcgagctgt tcggcggggc gcgcgtccgg ttcgtcaact ggagcacgca
    11641 gatctacgcc cagctgctgc tggcctcccg gcacccgcgc tgcctgatgg acccgatcga
    11701 ggtcgacctg ctggtcgaca ccgtccggca cttcccgcgc gtctgggacc acgacctcgc
    11761 ctgcccggac cgggaggccg agtcgatgtg gcggatggac atcccgctgt tcgacacgcc
    11821 cgcggacgcc gaccgggtga cgcacgacca cggcgaggcc gtcccggtcc ggctggcggc
    11881 ggcgccgctg gacatcgcgg ccgagcggat catggcgctg accgaggaga accggcgcag
    11941 gcagcggcag tacatctccg ccgggctcgc cggcggcgac gtgaccagcg aggacttcgc
    12001 cgcgacctgc ctggagcagg ccgaggccgt cgcggagcgg ctgtgcgcgg cggcgcgggt
    12061 caccggcgcg ccctggacgt cctacatcgt caccaaggac ggccacgagg aggtggacat
    12121 cgaggccgac ctctacaacg ggacggccgg catcgccctg ttcctcgccc acctcaacga
    12181 cctgaggccg cgcccggagt tcgagcgcac cgcccggctg gccctcgcgc acgcggtgga
    12241 gcacaccgac atgagccgcc tcggcgccta cccgggcatc ggcgggctga tctacacgct
    12301 cctccacctg caccggctgt gggacgaacg ggagctgctc gaccaggccg tcgccctcgc
    12361 cgacggcctc gccccggcca tcgagcagga cgaccgcctg gacgtctact tcggcgtcgc
    12421 gggcctgatc cccgtcctga tccagctcgc cgagacgacc ggcgggcacg gcgcgggcct
    12481 ggcgatccgc tgcgccgagc acctgctgaa gacggcgaac accgacggcg acgcgatgtc
    12541 ctggcccggc gacgacggcg gcgcggcgct cgccgacctc accggcttcg cgcacggcgc
    12601 gggcggcgtc ggctgggcgc tcgccatgct cggcaagcgc accgggcgga acgcctacgt
    12661 cgacgccgcg cgccgggcct tcgcctacga ggaccggcac ttcgacgagc tcgtccagga
    12721 ctggtacgac ctgcggtcct cgccgggcgg cccgatctgg aacgaccggc acttcgccaa
    12781 cgcgtggtgc aacggctcgg ccgggatcgg cctcgcccgc ctcgcgacct gggacgtcct
    12841 cggccgcgag gacgaggaca tggtgcgcgg agccacccgc gggctgaccg cgaccgtccg
    12901 caacttcccc cggctgatga acgacacgct ctgccacgga cggtccggga acgccgagct
    12961 gctgctccgg cacgcgctgc tccgcgagga gcccgcgttc cgcgtggagg ccaacctgca
    13021 cgcccagaac cagtggcgga acctcgccga ggcccggacc ggacccgagt cggggttctt
    13081 ccccgggctg atgctcggca tggcgggctt cggcatgcac ttcctgcgcc tggcccgtcc
    13141 cgagcggatc ccgtccgtcc tgctgctcga cccgccgacc cgaccctgag gagtgatgac
    13201 gagtatgtcc gtggacgcct gccaggagtt catgaccgcc gccggcaccg accccgacct
    13261 cgcgctgcgg atgcgggcca tgaccggggt gcccgagctg ctccggctcg cccgtgacca
    13321 cgggtacgag ttcaccgtgc ccgacctcgc cgccgtctcc atggcctcgg cccgcgagag
    13381 cggcgagccg ggtcggccgc ccgccgccgc gggacccgcc gccgagacgt ccgtgctgca
    13441 ctccgagtac gcgctgggcg atctgcccgg tttcgccgag gtgctcgacc tgcttccgct
    13501 ggtcaagatc cgtccgccgt cggtggacat ggaccggttc gcggacgcct tcgacccggc
    13561 cgacctggcg tccaccggct tcgcgccgag cggccccgag taccggcggt ggcgggcggg
    13621 cgtcaggacg gcccccggcg accgccgcga cttccacctg gtcaacctgg acgaccatgt
    13681 gacccacccc ggctacgagt cctacctgga cgccaaggtc cggctggtcg gggcgctgga
    13741 gaaggtgttc gggccggagg tccggttctc cgggagcatg tggtacccgc cgtcgtccta
    13801 ccggctctgg cacaccaaca aggaccagcc cggctggcgg atgtacctga tcgacttcga
    13861 cgacgacttc gacgacccgt ccgacacctc gttcttccgg taccagacgc cgggcaccgg
    13921 cgagctggtc acgctgcggg agcggccccg gatggcgcgg ttcttcaaga tcgagcagga
    13981 gccggagcgg ctgttctggc actgcatcgt gaacccgacc gagcggcacc ggtggagctt
    14041 cggcttcgtc gtccccgacc actggaaggc cgcgctggag gccgccgcgt gaccgcaccc
    14101 cccgccctcc cggacgcggc ggacgcggcg ggccccgccg ggatcccgcc cgccatcgcc
    14161 gcgtccgggc tgcgcaagcg gtacggggac gtcgtcgccg tggacggcgt ggacctgtcg
    14221 gtcgaggccg gggagtgctt cgcgttcctc ggcccgaacg gcgcgggcaa gtccaccacg
    14281 atctcgatgc tgtgcgcgct gacccggccg accgcgggca gggtcgcgat cgccgggcac
    14341 gacacgctcg ccgacccgct ggaggcgcgc cgccggatcg gcctggtgtt ccaggagtcc
    14401 acactcgacc tcggcctcac cgccgccgag aacctgcgct tccacgccga cctgtacgac
    14461 gtgccgcccg ggctgatccc cgaacgcgtc gaccgcgcgc tcgatctcgt cggcctcacc
    14521 gcggagcgcg accggatcgt cgggacgttc tccgggggga tgcgccgccg cctggagatc
    14581 gcccgcgcgc tgctgcaccg gccgcggctg atcgtcctgg acgagccgac gctcggcctc
    14641 gaccctcacg cgcgcgcacg agtctgggag cacctgcggg ccgtccggga acgcgaggcc
    14701 gtcacgatct tcctcaccac gcactacctg gacgaggcgg agcagtgcga ccgggtcgcg
    14761 atcatcgacg ccgggcggat cgtcgcgcag ggctcccccg ccgcgctgaa ggccgaactg
    14821 accgcgccgg gcgcgccccc gccgtcgctg gacgaggtgt tcctgcacca cacgggccgt
    14881 ccgctgcacg acgacaccga gctcggggaa ccgcccgcgg cggctccccc accggtgcgg
    14941 ccggaggaca tgtccctccc gcccgcgcgg cggccggcgg cggagttccg ggccgtccgc
    15001 atggtgtggc ggcgcgacct gctgatctac cggcgggacg ggggcggggc gctgctggcg
    15061 atggcgcagc cgctgctgtt cctgttcatc ctcggggtcg ggctgtccgg gctgatgccg
    15121 gggatcgggc aggggaccta ccagctgttc gtgttctccg gcgcgctcgt cacggccgcg
    15181 ctcgggcccg ccgtggcggt cggcgcgtcc ctgctgtggg agaagcaggc cgggttcctg
    15241 cgggagatgc tggccggtcc cgtccggcgc gagtcgctgc tgctcggcaa gtgcctgggc
    15301 ggcgcgacca tcgcgaccgt ccaggggacg ctgctgctcg ccgccgggcc gctgatcggc
    15361 gtcccggcca agccgcagct gatcgtcatg ctcgccggac agctcgcgct gacgtcgctg
    15421 gcgatgacgg cctgcggggt gctcgcggcg acgttcgtcc ggcgtccgcc cacctacggg
    15481 acggccatgt cggtgctggt cgcgccgctg acgttcctgt ccggcgcgat gttcccgctc
    15541 gccgggctgc ccgcctggct gcgcgccctc gcgctcgccg acccgctcac ctacgcggtg
    15601 gacgcgctgc gccgcaccgt cgcctcgcag ctgccgtccg cgccgccgca cctgttccgg
    15661 ccgctcgcga tcggcggctg gcacccgccg atcgtcgccg agtggacgct cctcgccctg
    15721 ctcgcgctcg tcccgctgct ctggtcggcc caccgcttct cccgcgccga ctgaccccgg
    15781 cccgacgcgg acgccccggc ctttccacgg gccggggtgt tcctgtgccc gaacccctcg
    15841 cccgcgcgcg tgttccgtgc tcctatgtgg ccatggaggc acgcatcaag gtcagcggcg
    15901 acgatccggc gcgggagacg gccgggctgc atgagtggct gcgcggcgac cggacgctcg
    15961 ccggacgcgt ccgcgccgag tccacgccac cgcgcgacgg cgagctgggc ggttcggcgg
    16021 acgtcctggt cgccgcgctc gggtccggcg gcgcggcggt cgccctcacg aacgtcctgg
    16081 tggcgtgggt gaagtcccgc cgtccggacg tcagcgtcac cgtcaccacc gagaacggca
    16141 gcgtgaagat cgacaccacg gacctgcccg ccgacgccgt cctgcccctg ctacgcgagg
    16201 tcctgcacgg cgacgagcac cggcgcgacc tgatccgacg cgacgacgcg gccctgcggg
    16261 acggcgacaa ggccctgcgg gacggtgatg actgacttct cccggtcccg ggcggtcctg
    16321 gtcggcacgg cggagtacgc ggacgcggcg ttcccgcggc tcccggccgc cgccaacagc
    16381 ctcgccggga tgcgcgccgt cctcaccgac ccgtccctgt gcggctggcc ggacgaccgg
    16441 gtgaccgtcg agtccgaccc gtccgactgg cgcgggctcg tgcggcggac gcgcgtcctg
    16501 gcccgcgaga ccgaggacgt cctgctcctg tacttcgtcg gccacggcgt gatgcttccg
    16561 cgcggcgagc tcagcctcgc cctcaccgac accgaggcgg acgacccgga cctcacgggc
    16621 ctggagtacc gccgcgtccg cgacctgctc cgcgacagcc cggccgcgac gaagatcgtc
    16681 atcctggact gctgctactc cggccgcgcc atcgaggccc tgaccgcgct ggacgccgtg
    16741 gccgactcca ccgacgtccg cggcgtctac accctgacgg ccagcgacca caccgcccac
    16801 gtcgtcccgc tggcggagca ggaggcggtc ccgacgtcgt tcaccggcca gttcctcgcg
    16861 ctcgtccgcg acggcgtccg ggacggcccg gagtccctca cgctgggcga tctgtacgtc
    16921 cacctgcgac ggcgcctgac cgcgcacggc ctccccgccc cgaaccagcg cggcaccgac
    16981 accgccgacc gctacccgtt cacccgcaac ccggcccacc gccgtccgcc tccgccctat
    17041 ccgtacccgc ggtcgcgccc agagcccggc gtcgtcgcgc gcccgcgtct tttccccgcc
    17101 gaaccgcgcg gcctctggtc cacgatcccc ggcgtccccg cgcttctgcc gcaggagacc
    17161 gtcggcgcga gcgccctcgc cttcagcccg gacggccgtt ccctggtcac cggccacctg
    17221 gacggctcgg tccacctccg gcgctggagc ttcgagggct cgacgcccct gcgaccggtg
    17281 gcgggcgaga gcgggccgat cagcgcggtc gccgtcacct ccgtcggccc gctggtggcg
    17341 tacgcggtac ccggccagga ggtcgggctg tactccctcg aaagctcggg cccggagcac
    17401 cggcttctgg ccgactcctg gtcctgcccg aagggccccg tgcgcacgct cgccttcacc
    17461 ccggacggcc ggtggctcgt ggccgggcag gccacgacga aggaggattc gcggacctgc
    17521 gtcgtctgga acgtccggac cggcggacgg ctcagggatc ccgagcccgc caaggactcc
    17581 tgggccctgt ggtggcacgc cagcgaccac gccgtgacga tcctgccgga cggccgggtc
    17641 ctgaccctcc agcacaggga cgggcacaac gcggtcgcga cctaccggct cgccggcgga
    17701 cagcccacca agatcctgga gtcccgtgtc gagatcggct tcgtccacgg ggtcgaggcc
    17761 gccgggatct cccccgacgg ccggacgatc gtgacggtcg agcacggccg gatccactac
    17821 tggcgcgcca ccgacgacgg ccacctggac ggtccgacct tcgcggaggg aaccccggcg
    17881 acgtcggtgg tcgttggacc tgagggacgg gcggcggcgc tgtgggcgcc gggcgagccg
    17941 ctgcgggtgt gggatctcca cgcgttcgag cagatcggag ggtcgcttca gcacagcggc
    18001 cagaccaggg cggtcgcctt cacgccggat ggcgcgacgc tggccgtggg cgacgccgaa
    18061 tggcccgtgc ggctgtggcg tcccgcctga acggacctcc ctgcgggcga ggtcaggggc
    18121 ggtaggtgag gggggcgtag ttcatcacgt ggtcgtggag catctgcggg gcggccgggt
    18181 cctgctggcg gaaggcctcg atgatccggg cgtgctcggc ggacttggag tagatctcgg
    18241 tcttgtggag ccggagggac agggtcgtcc agacctcgat gcccaggccc tcccagaccg
    18301 aggtaagcaa ctggttaccg ctgaagccga ccaccaaccg gtgaaagtgg atgctttcgc
    18361 ggatctgctc gtccaggtcg cccgcggtgg cggcctcggc gagccgggcg ttctgctcct
    18421 cgagctcgtc caggtgggcg gtgaggctcg gcagggcgag ttcgacggcg gtacgttcga
    18481 gcccggcccg gacggggaag atctccgcca ggtcgcgttc gtcgaacggg cggacgcggg
    18541 cgccgcggtt gggcagcgtc tcgatcagcc gcagggtctc cagcaggcgc aacgcctcgc
    18601 gcaccggccc ctggctgacg cccagctcgg tggccacacg gcgttcgacg atgcgctcgc
    18661 cgggctgcca gcggccactg gagatgccgt ccacgatgaa ctcgcggatc tggtcgacca
    18721 ggccggtgcg gcgcaggagg gcgggccggg cgacggtctg ggcgacggac tcggactggg
    18781 cggcggacgg tgcggcggac ggggcgttca cgtcccccat ggtagggggc gcgcgggaat
    18841 gaacactggt ccagacctct tgacctaggg catatgatcg atcattgatc aatgatgatc
    18901 ggtgatgagt ggcgcggcga ccccgcggca ccctctcccc gtacggagga agaacgccga
    18961 tggctgagac cacgaaggca gccccgggcc gagctcgccg gacccccggc ccgaccagca
    19021 ccaggggcac ggcggcgaag ggaaccccca aggccgccga caaccgcgcc agcgccgtcg
    19081 cccgccgcag ggccgacgac gaggcgcgcg ttgagtactt ccggcagatg ctgctggtgc
    19141 gccggttcga ggagcggacc gcccgggcct acaccgaggc caagatcggc ggttactgcc
    19201 acctgaacct gggtgaggag gccacggtcg tcggcctgat ggccgcgctg cgtcccaccg
    19261 actacctgtt caccaactac cgcgagcacg gctacgcgat cgccaagggc atcgagccgc
    19321 gccgcgtgat ggccgagctg tacggccgct ccaccggcgt gtccaagggc tggggcgggt
    19381 cgatgcacat gttcgacacc gaggcccggc tgctcggcgg ctacggcatc gtcggcggcc
    19441 agctcccgct cgcgaccggc gccgcgatgg cggtctccta ccgcggcggc gacgacgtcg
    19501 tgatggtcca gatgggcgag gggacggccg cgatcggcgc gttccacgag tcgctgaaca
    19561 tcgcagcgct gtggaacctg ccggtggtgt tcgtgatcat caacaacggc ctcggcatgg
    19621 gcaccacggt cgagcactcc gccgccgagc ccgagctgta caagcgcggc gccgcgtacc
    19681 ggatggccag catgcgggtg gacggcacgg acgtgatcgc cgtccgggac gcggcccgcg
    19741 aggccgtcga gcgcgcccgc gaggagaacc gtccctacct gctggagtgc accagcccgc
    19801 ggctgcgcgg ccactcggtc gtcgacccgg ccaagtaccg caccaaggag gagaaggagg
    19861 ccctcaaggc cgccgacccc ctcgccaagg cccagctgga gctccaggag gaggggctgc
    19921 tgtcggtcga ggacatcgag cgcctcgagg ccgagatcgc cgagatcgtg accgacgcgg
    19981 ccaccttcgc cgacgagtcc ccgcaccccg aggtgtcgac gctgttcgac tacacctacg
    20041 cgacgccggt gccgaacgac ctgccgcgac ttcccgccga cccgctcttc cgcgtctgag
    20101 agatcgactt ccatggcaac catcacctac cgccaggccc tgcgcgacac gctgcgggcc
    20161 gagatgctcc gtgacgagaa cgtcctgctc atgggcgagg agatcggcgt cttcgagggc
    20221 tcctacaaga tcaccgaggg cctgctgaag gagttcgggg agcgccgcgt gcgcgacacc
    20281 ccgatcgccg aggagggctt cgtcggcgcc gcgatcggcg cggccatgct gggcctgcgc
    20341 ccggtcgtgg agctcatgac gatcaacttc tcgttgctgg cgctggacca gatcgtcaac
    20401 cacgccgcca agatctacgg catgttcggc gggcagaagc ccgtcccgat ggtgatccgc
    20461 acgcccggcg gcggcggtca gcagctcggg gcgacgcact cgcagaacgt cgagctgtac
    20521 tactcgttcg tgccgggcct gaaggtcgtc gcgccgtcca cgccgctgga ggcgtccgcg
    20581 ctgctcaagg ccgcgatccg cgacgacgac ccggtcctgt tcctggagaa cctcgcgctc
    20641 tacaacacca agggcgaggt gccggacgac atcgccgacg tccagcccgc cgagatcggc
    20701 cgcgcggccg tgacccgcga gggcaccgac atcacgatca tcggctactc gcggatggcg
    20761 cacgtcgcgt ccgaggtggc cgagaggctg gccgccgagg gcgtgtccgc cgaggtcgtc
    20821 gacctgcgca gcctgcgccc gctcgaccgc gagaccatcg tggcctcggt ccgcaagacc
    20881 ggctcggcgg tcgtcgccga ggacgactgg ctgacctacg ggatcggcgc ggagatcgcc
    20941 gcgacgatcc aggagggcgc gttcgactgg ctggacgccc cggtccgccg ggtcgccatg
    21001 gccgaggtcc cgctgcccta cagcaagccg ctggagacgg ccgccctccc gtccgcagac
    21061 tccctgctca ccgccgttcg cgaaacgctc cgcgcgaccg gccgtccgac cctggagacc
    21121 gtccgatgac cgagatcctg atgcctcgcc tctccgacac catggaggag ggcgtcatcg
    21181 ccgcctggca gaagaagccg ggggacgagg tggccgtcgg cgacgtgctc tgcgagatcg
    21241 agaccgacaa ggccgtcatg gagtacgagg cctacgaggc cggcgtcctg acggagatcc
    21301 tcgtcgccga gggcgagacc gccgcgatcg gcgctccgat cgcgatcatc ggcggcaagg
    21361 gcgacgcccc ggtcacgacc gaggcgaagg ccgaggcccc ggccgccgag cccgcgcccg
    21421 ccgccgagcc tgagcccgcg aaggtcccgg cgctggtcgg cgccgagcgg ccgtcgtcga
    21481 acggcgtgtc gggcacccgc ccgccgtcgt ccccgctggc ccgacgcctg gcccgcgacc
    21541 acggcctcga cctgcacacg atcaccggca ccggccccgg cggacggatc atccgcgccg
    21601 acatcgaggc cgcgatccgc ggcggcgccc agcccgccgc cgccccggcc ccggctcccg
    21661 ccgccccggc cccggccgcc gcgtccgcgc cgaagcccgc cgctccgcag gtcgcggacg
    21721 aggacgtcga gcgcgtcccg ctgaaccggt tccgcaaggt cgccgcgcgc cgcctggtcg
    21781 agagcaagca gaacgcgccg cacttctacc tgaaccgcga cgtggacgcc gaggccctgg
    21841 tcgcgttccg cgggaccctg aacgaggcgc tcgccccggt caaggtcagc gtgaacgacc
    21901 tgatcgtcaa ggcgtccgcg cgggcgctgc gcgagcaccc gcaggtcaac acctcctaca
    21961 ccgaggacgc cctgctcgtg cacaagcgcg tccacgtcgg cgtcgccgtc gccgtcgcgg
    22021 acggcctgct cgtcccggtg atcaaggacg cggaccgcaa gtcggtgtcc cagatcggcg
    22081 ccgagacgcg cgagctggcc gccaaggccc gggacggcaa gctgtccccc gccgagatgt
    22141 ccggcggcac gttctcggtc agcaacctcg ggatgttcgg cgtggactcg ttctccgccg
    22201 tgatcaaccc gccggaggcg gcgatcctcg cggtcggcgc cgtccgcgcg gagccggtgg
    22261 tcaaggacgg ccaggtcgtc ccgggccagc gcatgacgat caccctctcg gtggaccacc
    22321 gcgccgccga cggcgccacc ggcgccaggt tcctggaccg cctggcccaa ctcctggaga
    22381 acccactcct gatcgtcgcg taacgtggca tggctgattt ttcagccatg caccacgcaa
    22441 cgacctcaac cggcgcgagc gcgtgaccaa ccgcacgggg gcaaagccga aggcgagccc
    22501 ccgagcggtt gatcgcgaag cgatgccgcg ctcgcacgag cattcgggct gagggcgagc
    22561 cgccaggcga gccctcagag ccgaaagctc cataaatacc gccgcccatg gcgcaccccg
    22621 tggggcggca ctacggcccc gcgcctcacc ggtgaccccg gtgggacgcg gggtcgcgtc
    22681 atttgctggg ttcgggcagg tccttgcagg agatcttggg gttgacgccg aggtagttga
    22741 gcggcccggc gaccaccgtc accgcgatcg ttccgctgcg gctgcagtct ttgacctggt
    22801 ccttgacggg acggtcgtag tagtggcgct ggcctgcggc gacggcgccg atgacgagcc
    22861 agaggagcag cacgaccgag gagatccgca tagcctcatc gtgcaggccg gatcgcgtga
    22921 cgacaagcgg ttcacgcctg acgacagggt gttccgtcca ggttgaaggc gtccgggcgg
    22981 ggttcggggt cgccgcctga ggcggttccg aggaagccga acccgacgct gccgcgcgga
    23041 gggacgccgc ggtcgtagtc ggcggcggtg acggtgacgt ccgcgccgga ctgccgctgg
    23101 gttccgttcc agatctgggt gatccgctcg tcccggccga aggtccagct gaggcgccag
    23161 ccgtcgaggg ccctggttcc caggttggt
//
