LOCUS       NZ_JADG01000008        22745 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Actinomadura oligospora ATCC 43269 P696DRAFT_scaffold00006.6_C,
            whole genome shotgun sequence.
ACCESSION   NZ_JADG01000008
VERSION     NZ_JADG01000008.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Actinomadura oligospora ATCC 43269
  ORGANISM  Actinomadura oligospora ATCC 43269
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 533483)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (09-JAN-2014) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Actinomadura oligospora ATCC 43269
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: ATCC 43269
            GOLD Stamp ID                     :: Gi22378
            Type Strain                       :: Yes
            Isolation Site                    :: soil, India
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-09-10
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000518265.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 02:24:37
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,332
            CDSs (total)                      :: 8,253
            Genes (coding)                    :: 8,185
            CDSs (with protein)               :: 8,185
            Genes (RNA)                       :: 79
            rRNAs                             :: 7, 2 (5S, 16S)
            complete rRNAs                    :: 7 (5S)
            partial rRNAs                     :: 2 (16S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 68
            CDSs (without protein)            :: 68
            Pseudo Genes (ambiguous residues) :: 0 of 68
            Pseudo Genes (frameshifted)       :: 7 of 68
            Pseudo Genes (incomplete)         :: 65 of 68
            Pseudo Genes (internal stop)      :: 1 of 68
            Pseudo Genes (multiple problems)  :: 5 of 68
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:28:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 393684
            Orig. end                         :: 416429
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JADG01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..22745
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22745
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22745
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12745](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12745
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    325..336
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 16.79"
                     /tool="antismash"
     gene            485..1492
                     /locus_tag="P696_RS0113665"
     CDS             485..1492
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (49-248). E-value:
                     6.3e-12. Score: 37.1. Matches aSDomain:
                     nrpspksdomains_P696_RS0113665_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019611320.1"
                     /locus_tag="P696_RS0113665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_026412796.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.3e-07, bitscore:
                     25.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 5.6e-06,
                     bitscore: 20.6, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLTGSAGFIGSHIADALEVSGHEVLPLDTATLADGGGGASGD
                     VRDAATVARALQGVDAVCHQAAMVGLGVDVYDLPDYASVNVLGTSVLLAEMARAGVRKL
                     VLASSMVVYGEGSYACAVHGPVRPRPRAESALASGAFEPACPRCAQPLTPGTIDESAPA
                     DPRNVYADTKLAQEHLAASWARMTGGSVVALRYHNVYGPRMPRDTPYAGVAALFRSALL
                     RGEAPKVFEDGLQRRDFVHVRDVARANVLALEHPSYAPFAAYNIASGRPRSIGDLAQAL
                     SAACGGPRPVVTGAYRLGDVRHIVASPHRAAADLGFTAEVAFEDGMAEFAAVTA"
     CDS_motif       494..544
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_P696_RS0113665_0001"
                     /evalue="9.40E-01"
                     /label="PKSI-KR_m1"
                     /locus_tag="P696_RS0113665"
                     /protein_end="20"
                     /protein_start="3"
                     /score="2.3"
                     /tool="antismash"
                     /translation="LLTGSAGFIGSHIADAL"
     aSDomain        632..1228
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_P696_RS0113665_NAD_binding_4.1"
                     /evalue="6.30E-12"
                     /label="P696_RS0113665_NAD_binding_4.1"
                     /locus_tag="P696_RS0113665"
                     /protein_end="248"
                     /protein_start="49"
                     /score="37.1"
                     /tool="antismash"
                     /translation="ATVARALQGVDAVCHQAAMVGLGVDVYDLPDYASVNVLGTSVLLA
                     EMARAGVRKLVLASSMVVYGEGSYACAVHGPVRPRPRAESALASGAFEPACPRCAQPLT
                     PGTIDESAPADPRNVYADTKLAQEHLAASWARMTGGSVVALRYHNVYGPRMPRDTPYAG
                     VAALFRSALLRGEAPKVFEDGLQRRDFVHVRDVARA"
     gene            1489..2217
                     /locus_tag="P696_RS0113670"
     CDS             1489..2217
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123: polyprenol-monophosphomannose synthase ppm1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547891.1"
                     /locus_tag="P696_RS0113670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_026412797.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.8e-17,
                     bitscore: 58.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVDVILPCLNEAEALPWVLDRMPSGYVPIVVDNASTDASAEVA
                     ARHGARVVHAPRRGFGEACHVGLLAATADTVCLMDADASLDPQDLPLLVAALAPPEPSP
                     STADAPPAGPLHGDFPDRPALVLGRRRPTGWRSWPPHARVANRVLARELNRRARTSLHD
                     LGPMRAARRADLLDLALTDRRFGYPLEMVLKAARANWHITELDVPYRPRTGRSKVTGTL
                     RGTIRAVHDMRDVLTTVGAV"
     gene            2214..2984
                     /locus_tag="P696_RS45225"
     CDS             2214..2984
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013152756.1"
                     /locus_tag="P696_RS45225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04282 family arsenosugar biosynthesis
                     glycosyltransferase"
                     /protein_id="WP_064744011.1"
                     /transl_table=11
                     /translation="MTTTPTPFAADLIVIAKEPVPGRVKTRLTPPFTPHQAAALAEAAL
                     KDTLEAVAATPVVRRVLALAGTPGPWLPDGFDVIPQRGDGLDERLANAFDDAHQGRPSF
                     LVGMDTPQLTPSLLVSAAAALTTHDAVFGRASDGGFWLLGLRTPNASLLRGVPMSRPDT
                     GHFQLCRLAEAALTVAHLPELTDVDTHDDAAQVAARAPATHFATAYRTLTTLRRTSEPT
                     SEAPAGNSEAPATNPAANARPQQSEPGAVAVGDR"
     gene            2974..3600
                     /locus_tag="P696_RS0113680"
     CDS             2974..3600
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653901.1"
                     /locus_tag="P696_RS0113680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_026412798.1"
                     /transl_table=11
                     /translation="MIGELYERALDEQALGERGAASVHIEDMTGARRPLPVTDWLRLRP
                     GDEGLLSRSEGPVLDVGSGPGRLTVALTERGVLAVGIDNAPTAVAMTVAAGGPALVGDV
                     FEQIPGAGLWRTILLADGNIGIGGDPSTLLRRLVLLLAPGGRILAEVNAPGSVSRRERV
                     RLRSGPTVGPWFPWAQVAADDLPPSGLVVSEHWEEATRCFVALTP"
     gene            3819..4949
                     /locus_tag="P696_RS45230"
     CDS             3819..4949
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653900.1"
                     /locus_tag="P696_RS45230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_245627648.1"
                     /transl_table=11
                     /translation="MNEQVGHLATAVGSRFTSRFHDERIAAWLGMALGVSFGTTFITGL
                     ISHFMQHPPVWLHWPPRPINLYRVTQGVHVIGGLATVPLLLAKLWTVYPRLLQWPPFRS
                     AAHALERALVLLLVGGALFQLVTGVLDIAYWYPFPFFFTVAHYWTAYVVIGALIIHIVN
                     EWTKARRTVMRKPDDGLDRRSFLLSVFAASGAVALFTVGEAVSPLARLALLAPRRPGVG
                     PQRLPVNRTALAAGVTQTARDPGWSLRVTGRVRRELSLSLAQLRAMPQHTVRLPITCVE
                     GWSSSGDWTGVRMRDVLARAGAPADARVRAVSLQSGGAYRTSEVDPRHWHDPDTLLALS
                     LNGEPLALDHGFPCRLIAPDRPGVLQTKWLTALVAE"
     gene            5048..5665
                     /locus_tag="P696_RS57430"
     CDS             5048..5665
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P696_RS57430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211245730.1"
                     /transl_table=11
                     /translation="MAAYVVGGAFIGLGLSGLVAHSRPGGWALWVGGAVVAHDGLLTPV
                     VLLAGLLVRRWRRFRLWLFVAGVLTLVALPLVLGLGRHPDNPSILPLHYLPNLIVAVTL
                     VAVATAFPWRRAGQALAAGFANSRRGCPPRGPAGDSRPRPDVEGETRTGRVDEQHTGRA
                     GEQVAGRVDEPNGGRSGHESSGRRDGRGAGRAGEQKSGGTDD"
     gene            5961..7160
                     /locus_tag="P696_RS45235"
     CDS             5961..7160
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="P696_RS45235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157429680.1"
                     /transl_table=11
                     /translation="MRRAGLATEDALPPLHAKARLLTWQMAPAVGYAAVAVGVLPVVVR
                     NMRWRVLLAVSWVMAVGWAVALAVSDGPGALARPLDAPTEYPAGLAAVGDHPLRWLRSF
                     TDELYAYPTHVRGHPPLPTLVFWALDAIGLHGTLWAALLIIGVGASSAAAIAVTVRVLA
                     GERVARRALPFLVLSPLSLWIATSMDAFFLGVGAWGVAFLAMRRPLAGGVLLGALPYLS
                     YGLLPLLAVPSVVLWMTRPPVRFWIVMAVGLAVIPTALTLGGFWWLDGIRATLDTYLVS
                     GGSARRSYAYFLGADIAVLGILTGPAVACVLPPLLRRGITARRKLREEPVVLLTAAAIV
                     AVLSLDVAGVTKGEVERIWLPFAAWLLPAASVLRAPARGWLTAQVVTALLVQALVLSEW
                     "
     gene            complement(7187..7855)
                     /locus_tag="P696_RS45240"
     CDS             complement(7187..7855)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042501.2"
                     /locus_tag="P696_RS45240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rhomboid-like protein"
                     /protein_id="WP_157429681.1"
                     /transl_table=11
                     /translation="MLRTRAATWAYVAALAMAEAVVWALSPESKAHVVDWVSTNVANLS
                     HHPVGSLAGSAFVPDSYPLAWVGLALVALSPVNALLGNRRTVLLFVLLHVTGTLVSEGV
                     VAWRVAHGALPEAARHQLDTGPSFVLVPGLVLVILFGTWWWRPLAVVGMWALWPYLFQG
                     LRQLDVAAVGHVTVMVLAVPSFLLFRRSRRATLARDARAAPQPTAGAADASTATEPSTP
                     "
     gene            complement(8072..9313)
                     /locus_tag="P696_RS0113700"
     CDS             complement(8072..9313)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019633456.1"
                     /locus_tag="P696_RS0113700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Ig-like domain-containing protein"
                     /protein_id="WP_245627649.1"
                     /transl_table=11
                     /translation="MRGKALVAVAAAVLGLTTACGGGGGGGDAKTAGHEEGVPQISITP
                     ANGSAKAKPDAGVTVTASGGTLSQVLVKLKDADVPGVLSADKKTWKSSWTLIPGGKYTV
                     QAVAASSKGKTATANSSFRTVNDTARTTINNVIPSPGEKVGTGMPIFIQFNKEVPERAR
                     EAIEKAIEIKSTYPTVGAWRWLSAGESFNGLPSLVFRTKDPWKANQSVQVSVHYAGLKI
                     GDSVYGDKDVTRKFKIGDSHVITVNNRSHKLTVKKNGAVVRSWGVSLGTGGEVQSDGID
                     HLKTTSGVHLTMDHVRLERMVAPGKKKGDAGYYDEQVPFATRISNSGEYIHQNMDDPSC
                     LGNRNCSHGCVRSPSSDAQWFMNWSYRGDMVVINGTGRELQWSNGWGYRQMPFDKWVGG
                     SKLGQPVTTAALGQ"
     misc_feature    9690..9704
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.53"
                     /tool="antismash"
     misc_feature    complement(9963..9977)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            10001..12745
                     /gene="lanKC"
                     /locus_tag="P696_RS45245"
     CDS             10001..12745
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653865.1"
                     /locus_tag="P696_RS45245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_051467486.1"
                     /sec_met_domain="micKC (E-value: 1.5e-240, bitscore: 795.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4.2e-16, bitscore: 54.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="APH (E-value: 4.3e-08, bitscore: 28.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.4e-07, bitscore:
                     24.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQYEPYCLADLFFYDKLGQRQNDASDFSLVARPVPEGWVRHDSD
                     VWMYYAPEGEGTLPSQGWKIHVSARLDDAERALAVIWDYCVPRGIVFKYLRGRSVLLMR
                     NSKAASRGASGKLVTIYPRDENECEIVLKELDELLDGIEGPYILSDLRYADGPLFVRYG
                     GFAERRCVGKDGELVPAIENGAGELVPDVRGATFSVPEWMTLPSFLEPHLEKRNSVRID
                     EMPYDFESVLHFSNGGGVYLARDRASGERVVLKEARPHAGLDVLGRDAVTRLKHERDIL
                     ERLSGLDVVPALRDYFVLGEHHFLVEEFVDGNPLQRQIVQRYPLTKADHDASALAGYTE
                     WALDMLAKIEDAVRLLHERGVVFGDLHPNNILVTASGRLCLIDFEVAVPAEAQARTTLA
                     NPAFLAPRDRRGVDVDRYALACMRYYLFAPQTTITLLMHPRKARQLAGLIAETFPVPHA
                     DFDDAVAVLLGPDPDPEPSPLDTLPLPGKAPWPDVRDAMHRAILASATPDREDRLYPGD
                     PAQFRDGGAVNIAHGAAGVLYALAETGADVPPEHVDWLVERALNPEVGMPLGLYDGLHG
                     VAHVLDRLGRRQEALDVADICLRETWDRLSLNLCSGLAGTGLNLLHLGEATGQTGLTDA
                     ALRMVELCAERIGGPDDVPEISGGDHPRAGLMHGSSGPALLFLHAYERGGDATLLDRAA
                     DALRQDLRRCMLAEDGSLQVNQGWRSLPYLDEGSVGIGLVVARYLRHRHDEEFERALTR
                     LARVAESGYFVQSGLFAGRAGIIAALATGLHAAPDPHDAPDAHDSNPDATHANDPRLDA
                     QISGLRWHAMPYGDGLAFTGDQLMRLSMDFATGTSGVLLALASALDDRRPALPFLDAPA
                     PARPAPETLPVTDGPSVTPAGSSGLMIGPSGRVGSLAKETPLA"
     misc_feature    10045..10059
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            12806..12937
                     /locus_tag="P696_RS55875"
     CDS             12806..12937
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653864.1"
                     /locus_tag="P696_RS55875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_157429682.1"
                     /transl_table=11
                     /translation="MALLDLQGLQAPTASGGASGGSGLTIVTCASHTPSNLSLALCH"
     CDS_motif       12806..12862
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGLQAPTASGGAS"
                     /locus_tag="P696_RS55875_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12863..12937
                     /prepeptide="core"
                     /locus_tag="P696_RS55875_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.10"
                     /molecular_weight="2213.5"
                     /monoisotopic_mass="2212.1"
                     /core_sequence="GGSGLTIVTCASHTPSNLSLALCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGLQAPTASGGAS"
                     /leader_location="[12805:12862](+)"
                     /alternative_weights="2231.5"
                     /alternative_weights="2249.5"
                     /alternative_weights="2267.6"
                     /alternative_weights="2285.6"
                     /alternative_weights="2303.6"
     misc_feature    12994..13010
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            13108..14856
                     /locus_tag="P696_RS45250"
     CDS             13108..14856
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653863.1"
                     /locus_tag="P696_RS45250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_034484842.1"
                     /transl_table=11
                     /translation="MRTAADRLVTRTAREGGLWTALLVLGALGGAVLQLLLPFAIGRAI
                     DGLTSGNIDGLTSGNPLHDRWTTIAASVVAGIAACEVLTAWATGVTGAAAAARLRRVLL
                     GRVLGAGPAITRRHPEGDLATRIGLNAEELGQAPAALVTAAALLIPTVGGLVALALIDP
                     WLLGALVAGLVAITLVLRGFLRATTVHAAGYQRTQSDIAARLTDALNGIRTIAAAGTAD
                     LETRRILTPLPTLREHGLRLWRANARAGVQAGLTVPLLEATVLAVGGWRLVSGGLSLGE
                     LYAAARYAVLGASLSGALGQIGQLARSRAAAGRVTEVLTEPVVQHGARRLSLHGSGTLE
                     FRNVAIRTPDGEGLRGVDFVIPGGGATAVVGRSGAGKSLLAALAGRLLDPDEGVVLLDG
                     VPLHDLSRTELRRAVGYAFERPVLLGESVTDAVALGLPSHTRAHEDYVRNAARAARADS
                     YLERLPSGYATALADAPMSGGERQRLGIARALAQGERLLVLDDATSSLDTVTEREIGAA
                     LTSAADGRTRLLVAHRVATAAEADNVLWLDDGHVRAQAPHADLWRDHPSYRALFADPTT
                     SPEGKA"
     gene            15003..16622
                     /locus_tag="P696_RS0113725"
     CDS             15003..16622
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018653862.1"
                     /locus_tag="P696_RS0113725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_245627650.1"
                     /transl_table=11
                     /translation="MLAWSVVEAGPALLVGQAVARAIGDGFAAGRPWVGTAWLATLALV
                     WTVAAVGARQVVLAVAATVEPFRDRLLTEAVSGTLRHAATEGRPPGSAAVARVNLQVEL
                     ARDALAALVTVVRSFAFTAVSVVVGLAVLEPLVLPWVLPPFVAGLTLFVASLPALARRQ
                     RAYLLADEATVAATAEMIGGLRDIAACGAEDRVGGAVRDRVATQEAAGRALARVTALRT
                     VALTVGGWAPVLLLLLAVPWLGRHGVGAAMVIGALTYLTQSLVPAFGGLVRGVGVSAVR
                     LGVSVDRVLTATTADAAPASCTTPAETDVRLRAVTAAYGPDAVPVIDELDLDVPSGGHL
                     AVVGPSGIGKSTLAAVITGLMRPRDGTVEIGGVRADQVDPSARVLIPQEAYVFRGTVRE
                     NLGYLTRDAEPPFTQAMERIGSADLVARLGGLDAELDPGALSAGERQLIALTRAYLAPA
                     RLVVLDEATCHLDPAAEARAETAFARRPGTLIVVAHRISSARRADRVLLMDGTRPHHGT
                     HDDLIRSSPPYAALAGRWRPAR"
     gene            16646..18643
                     /locus_tag="P696_RS0113730"
     CDS             16646..18643
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630269.1"
                     /locus_tag="P696_RS0113730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="prolyl oligopeptidase family serine peptidase"
                     /protein_id="WP_026412801.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.7e-52, bitscore:
                     172.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYPEAERGPVIDVLHGERVADPYRWLEDPAAPDTRAWLDAQDEL
                     YQKHIDPELRRTFRRRVVELADTGSVSAPVWRGDRRFTLRRVAGQEHAVLHVADGGEPE
                     RTLLDPTVLDPSGTTTLDAWRSDPSGRLLACQVSRGGTERAELLVLDVETGETLDGPID
                     RCRYSPVAWLPDGKGFYYVRAEPGDETRRRVRLHLIGEPPEHDTPVTEPATSHGVGISA
                     DGHWLVISTADGSDPRNDLYIADLTTATHQLRPVQQDVDARAAAAIGPDGRLYIVTDRD
                     APRVRLCVADPTNPSDWTELIPEDKEAVLSDFAFLDGLIAITRIRSGTSELSLHDARTG
                     ERRRDVPLPSPGILGPLSTRPGGGRELWFTHSGMATPEAVWHYDTSDNSLTLWEPSPSP
                     IVLPPLETHQITCTSADGTPVRVDVMARPHQGPDPRPAILYGYGGFGIPLTPSYAADAL
                     AWVDEGGVLAIAHLRGGGEDGTTSHRAGIQGRKQRVFDDFLAAAEELVSTGWTSPDRLA
                     IWGESNGGLLVGAALTQRPDLFAAAVCVAPLLDMVRYDLSGMGAMWHGEYGSPADPEAF
                     GWLRAYSPYHHVHEGTAYPATLFAVFDGDSRVDPLHARKMCAALQWATAGDRPVLLRRE
                     SDVGHASRSAGRSYDLAADLLAFVTTQTTP"
     gene            complement(18653..19303)
                     /locus_tag="P696_RS45255"
     CDS             complement(18653..19303)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017592837.1"
                     /locus_tag="P696_RS45255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_051467490.1"
                     /transl_table=11
                     /translation="MTRVILAENVHLFRSGLVALLDGEPDIRVVETVDCARKLLATAAH
                     CRPEVALVDLGLPDLDGVDATFRLLTLLPECRVILMAERRRPGDLRRAVEAGAEGFLLK
                     DTSPARLIQAIRDVANGERVIDADMAYAELATSRSPLTPRELEVLRETAKGATVAETAR
                     SLFLATGTVRNYLARIVTKVGARTRLEAVAIAEENGWLGGVVPRTQRSPRPGR"
     gene            complement(19775..20383)
                     /locus_tag="P696_RS0113740"
     CDS             complement(19775..20383)
                     /GO_function="GO:0008703 -
                     5-amino-6-(5-phosphoribosylamino)uracil reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893413.1"
                     /locus_tag="P696_RS0113740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dihydrofolate reductase family protein"
                     /protein_id="WP_026412802.1"
                     /transl_table=11
                     /translation="MRKITAGLFIALDGVVEDPQDWHFPYFNEEMGEAVSAQLGSADTL
                     LLGRRTYDGFAGAWPEREAAGGEDAGMAKALGDARKIVVSRQELEFTWRNSEVLRGELV
                     PAVAGLKDGPGGDIAMSGSVSVVRRLLEAGLLDELHLLVHPIAVRKGMRLFEDADAPLP
                     LTLLSSTPFSTGVVHLVYAKDENAPTGGYEKAKASLPQE"
     gene            20478..20993
                     /locus_tag="P696_RS0113745"
     CDS             20478..20993
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017625263.1"
                     /locus_tag="P696_RS0113745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD domain-containing protein"
                     /protein_id="WP_245627651.1"
                     /transl_table=11
                     /translation="MWITRPRPLPLLFLDVDGPLIPFGAATPYPTFEPEGDNPFLPRVD
                     PALGPRLGALPCELVWATAWTSDANDLVAPRLGLPHLPVVHWPAPSDQDDLDEQAGLHW
                     KTRHLVTWAAGRPFAWVDDELTETDRAWAAAHHPSPALLHHVDATRGLTLADFTTLTHW
                     LNHPQPQP"
     gene            complement(21029..21496)
                     /locus_tag="P696_RS0113750"
     CDS             complement(21029..21496)
                     /GO_function="GO:0016209 - antioxidant activity [Evidence
                     IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887528.1"
                     /locus_tag="P696_RS0113750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="redoxin domain-containing protein"
                     /protein_id="WP_026412804.1"
                     /transl_table=11
                     /translation="MLGTGSPAPDVLLEDTDGRATRLAALEADRAALVFFMRSTSCPVC
                     NRHVQDLVRSRDTFAADGVQVFIAVPEDRAVARAWKAKRGVPFPVLVGRGGVPHESVGL
                     SKKMFGSMRQSGSVLIDAQGVVRHAHGSTMPITAYDKKGITAAISQLNTRV"
     gene            complement(21507..22064)
                     /locus_tag="P696_RS0113755"
     CDS             complement(21507..22064)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012887527.1"
                     /locus_tag="P696_RS0113755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_026412805.1"
                     /transl_table=11
                     /translation="MTDRTWASAQLITAAQAGDRASIVAVLDGAHVHVRRFAEHLCATP
                     QDAEDAAQEALIILYRKIGSLRATGALASWMFRIVRNECLRRARSLVVEPEEIEPDLVT
                     SAEDEAIRRLEAERVAQAIQELPDVQRRVLIMRDVLGYPGRTVADRLGLSTPAMKSHLH
                     RARTRLRLSLNGQVGPDSTHAR"
     gene            complement(22141..22728)
                     /locus_tag="P696_RS0113760"
     CDS             complement(22141..22728)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890508.1"
                     /locus_tag="P696_RS0113760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_026412806.1"
                     /transl_table=11
                     /translation="MRKNQERRLALIDAAIEVLAREGARGLTFRAVDAQAEVPAGTASN
                     YFSNRDDLFTQIGGRIYDRLLPDEATMARSREGVQDEARYSELMHEVVNRVSSFNSGYL
                     ALLELRLESTRRPELREVLTKRIREDIDANLAHQAASDLPGDSTSVLLLYLALNWLILE
                     RLTLPDIFTEREAHDLVDAAVRRMLVTGAQVG"
ORIGIN
        1 gaccgcaccc acagaaacgg ggacgggatc gtcccggtcg ggacgaacgc ctcccacacc
       61 accagcacga tcatcgcgat gagcagcgcg cacgcccagc cgagcacgac gaaccaggcc
      121 gccgacgcga cgttcggacg gtccggatcc agcccgcgca tcagcgcctt gaggatggga
      181 ctcgccacgg tctcgccgac gatcgcggcc agcaccgtcc tgaccagcga gaaccgcgtg
      241 ttcagcaacc gtctggcccc gaaggccagg aacccgatga tcagcgtgga ccctgcgacg
      301 agtccgatcc agaacgccat gaccgaaaac gtattgatgc cgcgagctgg gaggatcccc
      361 cgcccgagcg agacgcttcc cccgtccggg cgaagttcta tcagaggttc agaagttctt
      421 acgaggttca tacgtccggc gcgcattcga gctgccggct gcggccgcga tctacgttcg
      481 ggtcatgcga gtgctgctca caggttcggc gggcttcatc ggttcgcaca tcgccgacgc
      541 gctggaagtg tccggccacg aagtcctgcc cttggacacg gccacgttgg cggacggcgg
      601 cgggggcgcg tccggcgatg tgcgggacgc ggcgacggtc gcccgcgcgc tccagggcgt
      661 ggacgccgtg tgccaccagg ccgcgatggt cggactgggc gtggacgtgt acgaccttcc
      721 cgactacgcg tccgtcaacg ttctggggac atccgtcctg ctggcggaga tggctcgcgc
      781 gggcgtgcgg aagctggttt tggcgtcgtc catggtcgtc tatggggagg gctcgtacgc
      841 gtgcgcggtg cacggcccgg tgcggccacg cccgcgagcc gaatcggcct tggcgtcggg
      901 agccttcgaa ccggcctgcc cccgctgcgc ccagccgttg actcccggga cgatcgacga
      961 aagcgcgccc gccgatccgc gcaacgtata cgccgacacc aaactcgccc aggagcacct
     1021 ggccgcctcg tgggcgcgca tgacgggcgg ctcggtcgtc gccctccgct accacaacgt
     1081 ctacggcccg cggatgcccc gcgacactcc ctatgcgggc gtcgcggcgc tcttccgttc
     1141 ggccctgcta cgcggagagg cacccaaggt cttcgaggac ggcctccagc ggcgcgactt
     1201 cgtccacgtc cgggatgtgg cccgcgcgaa cgtcctggca ctggagcatc cgtcctacgc
     1261 gcccttcgcc gcctacaaca tcgcgagcgg ccgaccccgc agcatcggcg acctggccca
     1321 ggccctgtcg gccgcgtgcg gcggcccgcg gcccgtggtc accggggcgt accggctggg
     1381 cgacgtccgc cacatcgtcg ccagccccca ccgcgccgcc gccgacctcg gcttcaccgc
     1441 cgaggtcgcc ttcgaggacg gcatggccga gttcgcggcg gtgaccgcat gacgaccgtc
     1501 gacgtgatcc tgccgtgcct gaacgaggcc gaagccctgc cctgggtgct ggaccgcatg
     1561 ccgtccggct acgtcccgat cgtggtggac aacgcctcca ccgacgcgtc cgcggaagtc
     1621 gccgcccgcc acggcgcccg ggtcgtgcac gcccctcgcc gaggcttcgg cgaggcctgc
     1681 cacgtcggcc tcctcgccgc cacggccgac accgtctgcc tcatggacgc cgatgcctcc
     1741 ctggaccccc aggacctccc cctcctggtc gccgccctcg cccctcccga gccctcacct
     1801 tcgactgccg atgctcctcc ggccggtccg cttcatggcg acttcccgga tcggccggca
     1861 ctcgtcctgg gacggcgacg cccgaccgga tggcgctcct ggccgccgca cgcccgcgtc
     1921 gccaaccggg tcctggcccg cgagctgaac cgccgcgccc gcacgtccct ccacgacctg
     1981 ggcccgatgc gcgccgcccg ccgagccgac ctgctcgacc tcgccctgac cgaccgccgc
     2041 ttcggctacc ccctggagat ggtcctcaag gccgcccgcg cgaactggca catcaccgaa
     2101 ctggacgtcc cctaccggcc gaggaccggc cgctccaagg tcaccggcac cctccgcggg
     2161 acgatccggg ccgtccacga catgcgcgac gtcctgacca cggtcggtgc cgtatgacga
     2221 ccacccccac cccgttcgcc gccgatctga tcgtcatcgc gaaggagccg gtgccgggcc
     2281 gcgtcaagac gcgcctgacc ccgccgttca caccgcacca ggccgccgcc ctggccgagg
     2341 ccgccctgaa ggacaccctc gaagccgtgg ccgcgacccc ggtcgtccgc cgcgtcctgg
     2401 ccctcgccgg aacgcccggc ccatggctcc cggacggctt cgacgtcatc ccgcaacgcg
     2461 gcgacggcct ggacgaacgc ctcgccaacg ccttcgacga cgcccaccaa ggccgcccgt
     2521 cgttcctggt cggcatggac accccccagc tgacgccgtc cctcctggtc agcgccgccg
     2581 ccgcgctgac gacgcacgac gccgtcttcg gacgggcgtc cgacggcggc ttctggctcc
     2641 tcggcctccg caccccgaac gcgtccctcc tgcgaggcgt ccccatgtcc cgtccggaca
     2701 ccggccactt ccagctgtgc cgcctggccg aggccgccct gaccgtcgcc cacctccccg
     2761 agctcaccga cgtggacacc cacgacgacg ccgcccaggt ggccgcgcga gctcccgcaa
     2821 cacatttcgc caccgcctac cggaccctca ccaccctccg ccggaccagc gaacccacgt
     2881 ccgaagcccc cgccgggaac tccgaagcgc ccgccacgaa ccccgcagcc aacgcccgtc
     2941 ctcaacagag cgagccgggg gcggtggccg tcggtgatcg gtgagttgta cgagagggcg
     3001 ctggacgagc aggcgctcgg cgaacgggga gccgcgtccg tccacatcga ggacatgacc
     3061 ggcgcgcggc gtccgctgcc ggtgaccgac tggctgcggc tgcgtccggg cgacgagggc
     3121 ctgttgtcgc gttccgaggg gcccgtcctg gacgtcggtt cagggccggg caggctgacc
     3181 gtcgcgctca ccgaacgcgg cgtgctcgcc gtcggcatcg acaacgcgcc gaccgcggtc
     3241 gcgatgaccg tggccgccgg aggccccgcg ttggtcgggg acgtgttcga gcagatcccc
     3301 ggcgcgggac tctggcggac gatcctgctc gcggacggca acatcggcat cggcggcgat
     3361 ccgtccacac tgctccgccg cctggtcctg ctcctcgccc ccggcggccg gatcctcgcc
     3421 gaagtgaacg ccccgggatc cgtctcccgg cgcgaacgcg tccgcctgcg cagcggcccg
     3481 accgtcggcc cctggttccc ctgggcccag gtggccgccg acgacctccc cccaagcggc
     3541 ctggtcgtgt ccgaacactg ggaagaggca acccgatgtt tcgtcgccct gactccatga
     3601 gtccgtcccg cccgggtccc aacggcccgg gaccacggac cgggcgcctg cgcttcgtct
     3661 ggaagcccgg cggcgcaccg gagagccaca cctccgccgc cgtgccctcg gccgccgtgt
     3721 cgtcggctgc cgtgtcgtcc gccgccgtgt cctccgcggt cgtgtcgtcc gcggcccggg
     3781 caaggggcca ccgaccacgt gtcggttcga tccggcaggt gaacgaacag gtcggccatc
     3841 tcgccacggc ggtcggttcg cgcttcacca gccggttcca cgacgagcgg atcgcggcgt
     3901 ggctgggcat ggcactcggc gtctcgttcg ggacgacgtt catcaccggc ctgatcagcc
     3961 acttcatgca gcatccgccg gtctggctgc actggccgcc ccggccgatc aacctgtacc
     4021 gcgtcaccca gggcgtccac gtcatcggcg gactggcgac ggtgccgctt ctgctggcca
     4081 agctctggac ggtctacccg aggcttctcc aatggccgcc gttccggtcg gccgcccacg
     4141 cgctcgaacg cgccctggtg ctcctcctgg tcggcggagc cctgttccag ctggtcacgg
     4201 gtgtcctgga catcgcctac tggtacccct tcccgttctt cttcacggtc gcccactact
     4261 ggacggccta cgtcgtcatc ggcgcgctga tcatccacat cgtgaacgag tggaccaaag
     4321 cgcgccgaac cgtgatgcgc aaacccgacg acggcctcga ccgccgctcc ttcctcctct
     4381 cggtcttcgc cgcatcgggt gcggtggccc tgttcaccgt cggtgaggcg gtctcgccct
     4441 tggcgcgcct ggccttgctc gctccgcgac gtccgggcgt cggcccgcag cgactcccgg
     4501 tgaaccgcac cgcgctcgcg gccggcgtca cgcagaccgc tcgcgacccg ggctggagcc
     4561 tccgggtgac cggacgagtc cggcgggagc tctcgctctc actcgctcag ctgcgcgcga
     4621 tgccacagca caccgtccgc ctgccgatca cgtgcgtcga aggctggtcc tcgtccggag
     4681 actggacggg cgtccgcatg cgggatgtcc tggccagggc cggagccccg gctgacgcgc
     4741 gggttcgagc cgtgtccctg cagagtggcg gcgcgtaccg aacctccgag gtggacccca
     4801 ggcactggca cgatcccgac acgcttctgg ccctgtccct gaacggcgag ccccttgccc
     4861 tggaccacgg tttcccgtgc cgcctgatcg ccccggaccg tcccggcgtt ctccagacca
     4921 aatggctcac ggccttggtc gcagagtgaa cagggacacc ggcccgcggc gttcgtcggg
     4981 cagcaggccg cacaccggcc acctcatgag cgttgtgttc aggcgtccgc aggtgggcgt
     5041 tgggcgcatg gccgcgtatg tcgtgggtgg agcgttcatc ggtcttggcc tttcgggtct
     5101 ggtggcgcat tcgcggccgg gcgggtgggc gttgtgggtc ggtggtgcgg tcgtcgcaca
     5161 tgacggcttg ctgacgccgg tcgtgcttct cgccgggctg ttggtgcggc ggtggcggcg
     5221 gttccggctc tggttgttcg tggccggtgt cctgaccctc gtggcgctgc cgctcgtgct
     5281 cgggctcggc cgccacccgg acaatccatc gatcctgcct ttgcactacc tccctaattt
     5341 gatcgtcgcc gtgaccctcg tcgcggtcgc gacggccttt ccctggcgga gggccggaca
     5401 agccttggcc gccggtttcg cgaacagccg tcgaggatgt ccaccgaggg gtcccgccgg
     5461 agactcccgg ccgcgacccg acgtggaggg ggagacccgc accggtcggg tggacgagca
     5521 gcacacgggg cgagcgggag aacaggtcgc cggtcgggtg gacgagccga acggcggccg
     5581 ctcgggccat gaatcttctg gtcggcggga tgggcgaggc gctggtcggg ccggtgagca
     5641 gaagtcaggc gggacggatg actgagcaga gttccgggcg cggtggcaca cggacgaaga
     5701 agccgggcgt cagcgagtcg gcggcgggtc atgacggatc ggtcgtcgcc acgatgccgg
     5761 tgggcgacgc ggagatcgag gctggaacgg gatcggcccc tggcggaacc gggccctccg
     5821 ctaccgggcc ctccgcgacc gagccctccg gtactgggcc ttccggtagg gcctttcggt
     5881 attgggcctt tcggtactgg agttcggggg gtgtggtctg ggcaggtttg atcgtcgggg
     5941 cgttcgtcgt cggggaggtg atgcggaggg ctgggctcgc cactgaggac gcgttgccac
     6001 ccctgcatgc gaaggcgcgg ttgctgacct ggcagatggc tccggcggtc ggatacgcgg
     6061 ccgtcgcggt cggtgttctc cccgtggtcg tgcggaacat gcggtggcgg gtcctccttg
     6121 cggtgtcgtg ggtgatggcg gtcgggtggg ccgtcgcgtt ggcggtcagt gacgggcccg
     6181 gtgcgctggc tcggccgctg gacgcgccga cggagtatcc ggcggggctg gcggcggtcg
     6241 gtgatcatcc gttgcgctgg ctgcggagtt tcaccgatga gctgtacgcg tacccgacgc
     6301 atgtgcgggg gcacccgccg ctgccgacgc tggtgttctg ggcgctggac gcgatcgggt
     6361 tgcacgggac gctctgggcc gcgctgctga tcatcggggt cggggcgtcg tccgcggcgg
     6421 ccatcgcggt gacggtgcgg gtgctggcgg gggagcgggt ggcgcggcgg gcgctgccct
     6481 tcctggtgct gtctcctctc tcgctctgga tcgcgacgtc gatggacgcg ttcttcctcg
     6541 gggtcggggc ctggggcgtc gcgttcctcg cgatgcgcag gccgttggcc ggtggtgtgc
     6601 tgctcggcgc cttgccctac ctaagctacg gattgctccc cctgctggcc gtaccgagcg
     6661 tcgttctgtg gatgactcgt ccaccggtga ggttctggat agtgatggcg gtcggactcg
     6721 ccgtcatccc cacggccttg acgttgggag gcttctggtg gctggacggt atccgcgcca
     6781 cgctcgacac ctatctcgtc agcggcggct cggcacgcag gtcctatgcc tatttcctag
     6841 gcgcggacat cgccgtcctc ggcatcctca cgggaccggc cgtcgcgtgc gtcctgcccc
     6901 cgctccttag gcggggcatc acggcgcgac ggaaactccg cgaggagcca gtcgtcctcc
     6961 tgacggccgc agcgatcgtc gcagtcctca gcctggacgt agcgggagtg acgaaaggcg
     7021 aggtcgagcg catctggctt ccgttcgcgg cgtggctgct gccagcggcg agtgttctac
     7081 gcgcgcccgc acgaggatgg ctgacagcac aggtggtgac ggcgctgctc gtccaagcgc
     7141 tcgtgctctc cgagtggtga gccgacccgc tcgtcgacag gcccgctcaa ggcgttgagg
     7201 gctcggtcgc cgtggaggcg tcggcagccc cagctgtcgg ttggggcgcg gctcgtgcgt
     7261 cgcgcgcgag ggtggcccgt cggctgcgcc gaaacagtag gaacgaaggg acggccagca
     7321 ccatcacggt gacatgtccg actgccgcga cgtccagttg gcggagcccc tggaagaggt
     7381 agggccacag ggcccacatg ccgaccaccg ccaggggacg ccaccaccac gtcccgaaca
     7441 ggatcaccag gacgaggccg gggacgagca cgaacgaggg cccggtgtcg agctggtggc
     7501 gggcggcctc cgggagcgcc ccgtgcgcga cgcgccacgc gacgacgccc tcactgacca
     7561 gcgtccccgt cacgtgcagg aggacgaaca gcaggaccgt ccggcggttg cccagcagcg
     7621 cgttgacggg ggacagcgcc accagcgcca aaccgaccca cgccagcgga tacgaatcgg
     7681 ggacgaacgc ggatccggcc agggagccca cgggatggtg ggacaggttg gccacgttgg
     7741 tgctcaccca gtcgacgacg tgcgccttgg actccgggga cagcgcccag accacggcct
     7801 cggccatggc gagcgccgca acatacgccc aggtggccgc tctcgtcctc agcacgagtc
     7861 catagtgcac cgtcgcgcac gcgccacgag gtcggagcgt gccccacgac gattccggaa
     7921 cccggccgga tcgaccatcc agggcaaagg agacggcccg gcgctctcgg ggaggagaag
     7981 cgccgagccg tgtccggagg gtgcgggtga ggtcgtggcg ggaggcttta ctgaccgtcg
     8041 ggggagggtc tgcttccgag gaagggaggg cctactggcc gagggcggcg gtggtgacgg
     8101 gctggccgag cttgctgcca cccacccact tgtcgaacgg catctggcgg tagccccagc
     8161 cgttggacca ctgcagctca cgcccggtgc cgttgatgac caccatgtcg ccccggtagg
     8221 accagttcat gaaccactgc gcgtcggacg agggggagcg gacgcagccg tgcgagcagt
     8281 tgcggttgcc gaggcaggac gggtcgtcca tgttctggtg gatgtactcg ccgctgttgg
     8341 agatgcgcgt ggcgaacggc acctgctcgt cgtagtagcc ggcgtcgccc ttcttcttgc
     8401 ccggggcgac catccgctcc agccggacgt ggtccatggt caggtgcacg ccgctggtgg
     8461 tcttgaggtg gtcgatgccg tcgctctgca cctcgccgcc ggtgccgagg ctgacgcccc
     8521 acgagcggac gaccgcgccg ttcttcttca cggtcagctt gtgcgaccgg ttgttgaccg
     8581 tgatgacgtg ggagtcaccg atcttgaact tgcgggtgac gtccttgtca ccgtagaccg
     8641 agtcgccgat cttcaggccc gcgtagtgga cgctcacctg gacgctctgg ttcgccttcc
     8701 acgggtcctt cgtgcggaac accagcgagg gcagcccgtt gaacgactcg cccgcgctca
     8761 gccaccgcca ggcgcccacc gtcgggtagg tcgacttgat ctcgatggcc ttctcgatgg
     8821 cctccctggc ccgctccggg acctccttgt tgaactggat gaagatcggc atgcccgtgc
     8881 cgaccttctc gcccgggctc gggatgacgt tgttgatcgt cgtccgcgcg gtgtcgttca
     8941 ccgtcctgaa cgagctgttc gcggtcgccg tcttgccctt gctggacgcc gcgaccgcct
     9001 ggacggtgta cttcccgccc gggatcagcg tccaggacga cttccaggtc ttcttgtcgg
     9061 ccgacaggac gccgggcacg tcggcgtcct tcagcttgac cagcacctgg ctcaacgtcc
     9121 cgccggacgc cgtcaccgtc acgcccgcgt ccggcttcgc cttggccgaa ccgttcgccg
     9181 gggtgatcga gatctgggga acgccttcct catgtccggc ggtcttggcg tcgccaccgc
     9241 cgccgccacc accgcacgcc gtcgtcagcc ccaagaccgc cgcagccacc gccaccagtg
     9301 ccttacctcg cacggttctc cctcatcagc acgcaatccg cagaaagcac attagcgaca
     9361 agaatgccgg tgcttcttcc cgcattcccc acccggcccc gacacctggg aggacctgcg
     9421 ccccggctcc gtccccccgt ccgggcgaac gtcggtcagt aagacgtcgg aaacctccca
     9481 ggagttcgca tctttcccag aagtgaccgc agtccacctg cctgtacacg gaccgtggag
     9541 tgccccggtt cgcccgttcc gtgcctcggt cgcgtcccgg ccatgccgtg acccggctcc
     9601 ggtcccttct cagcgcgctt caggtcgcgc gcaccggccc ggggcgatca cgcctccgcc
     9661 cgccggacga gcccacggca cgaccccacg gacgaggtgg tccgccgacg tccgccgagc
     9721 ccgcgacgct cccccacggc atcggccccc ggaggagccg atcagggacg tccacgccat
     9781 cgcgacgcgc gcccacgggt aggtccaggc tgcgcggcgc cgtcagcgcc ctgcgcgccc
     9841 gaacgcttcg gcgcgcacgt cctccgcctt cacgggacgg cgtggagaaa cgcacacacg
     9901 cgatagtgcg ttcctcacaa tcaagtattg cggattcaac ttggctcgag cgcctcggcc
     9961 ggtgatgctg aatttcagcc gagcacagag gaggaccgcg gtggaccagt acgagcccta
    10021 ctgcctcgcc gatctgttct tctacgacaa actcggccaa aggcagaacg acgcgtcgga
    10081 cttctcgctc gtcgcacgtc cggttcccga aggatgggtc cggcacgatt ccgacgtctg
    10141 gatgtactac gcaccggaag gcgaggggac gctcccgtcc cagggctgga agatccatgt
    10201 gtccgcccgg ctggacgacg ccgagcgcgc cctcgccgtg atctgggact actgcgtccc
    10261 gcgcgggatc gtgttcaagt acctgcgcgg ccggtccgtc cttctcatgc gcaattccaa
    10321 ggccgcctcg cgtggcgcca gcggaaaact cgtcaccatt tacccgaggg acgagaatga
    10381 atgcgagatc gtcctcaagg agctggacga gctgctcgac ggcatcgagg gcccctacat
    10441 cctgagtgat ctccggtacg cggacggtcc gctcttcgtc cgctacggcg gtttcgccga
    10501 acggcgctgc gtcggcaagg acggcgaact cgtccccgcc atcgagaacg gcgcgggcga
    10561 actcgtcccg gacgttcggg gagcgacgtt ctcggtgccc gaatggatga cgcttccgtc
    10621 cttcctcgag ccgcatctgg aaaagcggaa ctccgtccgc atcgatgaga tgccctacga
    10681 cttcgaaagc gtcctgcatt tctcgaacgg cggcggcgtc tacctcgccc gcgaccgcgc
    10741 ctccggcgag cgcgtcgtcc tgaaagaggc ccgtccgcac gccggactcg atgttctcgg
    10801 ccgcgacgcg gtgacccgcc tcaagcatga gcgcgacatc ctcgaacgcc tttccggact
    10861 ggacgtggtg ccggcgctgc gcgactactt cgtcctcggg gagcaccatt tcctcgtcga
    10921 ggagttcgtg gacgggaacc cgctccagcg tcagatcgtc cagcggtatc cgctgacgaa
    10981 ggcggaccac gacgcgtcgg cgctcgccgg gtacaccgaa tgggcgctgg acatgctcgc
    11041 caagatcgag gacgccgtcc ggctgctgca cgagcgcggg gtggtgttcg gcgacctgca
    11101 tccgaacaac atcctggtga cggcgtccgg acggctctgc ctcatcgatt tcgaggtggc
    11161 cgtccccgcc gaggcgcaag cccgcacgac cctcgccaac ccggcgttcc tggcgccgcg
    11221 cgaccggcgg ggcgtcgacg tcgaccggta cgcgctcgcc tgcatgcgct actacctgtt
    11281 cgccccgcag accacgatca ccctgctgat gcacccgcgg aaggcccgcc agctcgcggg
    11341 cctgatcgcc gagacgttcc cggtgccgca cgcggacttc gacgacgccg tcgccgtcct
    11401 cctcggaccg gaccccgatc cggagccgtc gccgctcgac acgctgccgc tcccgggcaa
    11461 ggccccctgg ccggacgtcc gggacgcgat gcaccgggcg atcctggcct cggccacccc
    11521 cgaccgcgag gaccgcctct accccggcga cccggcgcag tttcgggacg gcggcgcggt
    11581 caacatcgcc cacggagccg ccggggtcct ttacgccctg gccgaaaccg gggcggacgt
    11641 cccgccggaa cacgtcgact ggctggtcga acgcgcgctg aaccccgagg tgggcatgcc
    11701 gctcggcctg tacgacggcc tccacggcgt cgcgcacgtc ctcgaccggc tcggccgccg
    11761 ccaggaagcg ctggacgtcg cggacatctg cctccgcgag acctgggacc ggctcagcct
    11821 gaacctgtgt tccggactgg ctggaaccgg cctcaacctc cttcacctgg gcgaggccac
    11881 cggccagacc ggcctgaccg acgccgcgct gcgcatggtc gagctgtgcg cggagcggat
    11941 cggcggcccg gacgacgtcc cggagatcag cggcggcgac catccgcgcg cgggactgat
    12001 gcacggttcg tccggcccgg cgctgctgtt cctgcacgcc tacgaacgcg gcggcgacgc
    12061 gacgcttctc gaccgcgccg ccgacgcgct ccgccaggac ctgcgccgct gcatgctcgc
    12121 cgaggacgga tcgctccagg tcaaccaggg ttggcgcagc ctgccctacc tggacgaggg
    12181 atccgtcggc atcggactcg tggtcgcccg ctacctccgc caccgccacg acgaggagtt
    12241 cgaacgcgcg ctgacccgcc tcgcccgggt cgccgaatcc ggctacttcg tccagtccgg
    12301 cctgtttgcc ggacgtgccg ggatcatcgc cgccctcgcc accggcctcc acgccgcccc
    12361 cgacccgcac gacgccccgg acgctcacga ctcgaacccg gacgcgacgc acgccaacga
    12421 tccgaggctg gacgcgcaga tcagcggcct ccgctggcac gccatgccct acggggacgg
    12481 cctcgccttc accggcgacc agctcatgcg gctgtcgatg gacttcgcca ccgggacgtc
    12541 cggggtgctg ctcgccctgg cgtccgcgct cgacgaccgg cggcccgcgc tgcccttcct
    12601 cgacgccccc gcgcccgctc gccccgcccc cgagaccttg cccgtcaccg acggtccgtc
    12661 cgtcaccccg gccggttcgt ccggcctcat gatcggccct tccggccgcg tagggagcct
    12721 ggccaaggag acccctctcg cgtgacgccg gaaaaggccc gacccccgtc cacccacgga
    12781 agggaaagga ggtgtagcaa ccaccatggc gcttctcgac ctgcagggcc tccaggcccc
    12841 caccgcctcc ggcggagcca gcggcggtag cggtctgacc atcgttacct gcgcatcgca
    12901 cacgccgagc aacctgagcc tcgcgctctg ccactgagcc ccggcactcg ggcgtgatca
    12961 tccgggtggc cgccactgag gggccacccg caacgcccaa agccgccgcg tgcggcgcgg
    13021 tccctgccgc gccgcacgcg gcggtccctt gtccacggaa gaaggacgga cgcggacggc
    13081 cgtccacgca gaaggaagga tgcacggatg cggacggcgg cggaccgcct ggtgacgcgc
    13141 accgcgcgcg agggcggcct ctggacggcc ctcctggtcc tgggcgcgct cggcggggcc
    13201 gtcctgcagc tgctcctgcc gttcgccatc ggacgcgcga tcgacggcct gacctccgga
    13261 aacatcgacg gcctcacttc gggcaacccc ctccacgacc gttggacgac catcgccgcg
    13321 tccgtcgtcg cgggcatagc ggcatgcgag gtcctgacgg cctgggcgac cggcgtcacc
    13381 ggcgccgcgg cggcggcccg gctgcgccgc gtcctgctcg gccgcgtcct cggcgcggga
    13441 ccggcgatca ccaggcggca ccccgagggc gacctcgcga cccgcatcgg gctgaacgcc
    13501 gaggaactcg gccaggcccc ggcggcgctc gtcaccgccg ccgccctgct catcccgacc
    13561 gtcggcgggc tggtcgccct ggccctcatc gacccctggc tgctgggcgc gctggtcgcg
    13621 ggcctggtcg cgatcacgct cgtcctgcgc ggattcctgc gcgcgaccac cgtccacgcc
    13681 gccggatacc agcgcacaca gagcgacatc gcggcccgtc tcactgacgc gctcaacgga
    13741 atccgcacga tcgccgccgc cggaaccgcg gacctagaga cccgccggat cctcaccccg
    13801 ctgcccacac ttcgcgaaca tgggcttcga ctttggcgcg ccaacgcgcg cgcgggggtg
    13861 caggcagggc tgaccgttcc gctgctggag gcgaccgtcc tcgccgtggg tggatggcga
    13921 ctcgtctcag gcggactcag cttgggcgag ttgtacgccg cagcgcgcta tgccgtgctc
    13981 ggcgcgagcc tttcgggcgc gctcggccag atcggccagc tcgcccgatc gcgcgcagcc
    14041 gcgggccgcg tcaccgaagt gctcacggaa cccgtcgtcc agcacggcgc acgccgtctc
    14101 tcactgcacg gttccggaac cctcgaattc cggaacgtcg cgatccgcac accagacggc
    14161 gaagggctgc gcggcgtcga cttcgtgatc ccgggcggcg gtgcgaccgc cgtggtcgga
    14221 cgttccggcg cgggcaaatc cctgctcgcc gccctggcag gacgcctgct cgacccggac
    14281 gaaggcgtcg tcctcctgga cggcgtccca ctccacgacc tgtcgcgcac cgaactgcga
    14341 cgcgctgtcg gctacgcctt cgaacgtccc gtcctgctgg gggagagcgt caccgacgcc
    14401 gtggcactcg gcctcccttc ccacacgcgc gcgcacgagg actacgtgcg gaacgcggcc
    14461 cgcgccgccc gcgcggactc ctacctggaa cggctgccct ccggctatgc caccgccttg
    14521 gcggacgcgc cgatgtcggg tggcgagcga caacgcctag gaatcgctcg tgcgctcgcg
    14581 caaggggaac ggctcctcgt cctggacgac gcgacctcga gcctcgacac cgtgaccgaa
    14641 cgcgagatcg gcgcggccct caccagcgcg gccgacggcc gaacccgcct gctcgtcgcc
    14701 catcgcgtcg ccaccgccgc cgaggccgac aacgtcctct ggctggatga cggacacgtc
    14761 cgcgcccaag ccccccacgc cgacctctgg cgcgaccacc cgtcctaccg ggccctcttc
    14821 gccgacccca caacctcccc cgagggaaag gcatgaccac caccccccgc ccccgcacga
    14881 gcccaccccc cgcgcacaga gaacgaacgc ccgacggggt ctcgcttccc gcacgcgcgg
    14941 gaagcggaac gcggacgttc gtggttcagg cgttgctcgc ggaaccgcgg gcggtattgc
    15001 gggtgcttgc gtggtcggtc gtagaagcag ggcccgcgct gctcgtcgga caagccgtcg
    15061 cgcgcgcgat cggggacggc ttcgcggcgg gacgtccatg ggtgggcacc gcctggctcg
    15121 cgacactcgc cctggtctgg acggtcgccg cggtcggggc gcgccaggtc gttctggccg
    15181 tggccgccac ggtcgagccg tttcgcgacc ggctgctgac cgaggccgtc tccgggacgc
    15241 tgcggcacgc cgccaccgaa ggccgcccgc ccggatcggc ggccgtcgcg cgcgtgaacc
    15301 ttcaggtgga gctggcacgc gacgcgctcg ccgcgctggt caccgtcgtt cgctcgttcg
    15361 cgttcaccgc tgtcagcgtg gtcgtcggcc tggccgtcct ggagccgctc gtcctgccct
    15421 gggtgctgcc gccgttcgtc gcgggcctca cgctgttcgt ggcgtcgctg cccgcgctcg
    15481 cccgccgcca gcgcgcgtac ctcctcgcag acgaggcgac ggtcgccgcg acggccgaga
    15541 tgatcggcgg actccgcgac atcgccgcct gcggcgccga ggaccgcgtc ggcggcgcgg
    15601 tccgcgaccg cgtggcgacg caggaggcgg cgggccgcgc cctcgcccgc gtcaccgccc
    15661 tccgcacggt cgcgctgacc gtcggcggct gggccccggt gcttctgctc ctgctcgcgg
    15721 tgccctggct gggccgccac ggtgtcggcg cggccatggt gatcggcgcg ctcacctacc
    15781 tgacgcagtc gctcgtcccc gcgttcggcg gactggtccg tggggtcggc gtgagcgccg
    15841 tccgcctcgg cgtctccgtg gaccgcgtcc tgaccgccac caccgccgac gcagcgccgg
    15901 catcctgcac cacaccagcg gagacggacg tgcggctccg cgcggtcacc gccgcctacg
    15961 gcccggacgc ggtgccagtg atcgacgagc tggatctgga cgtcccgtcc ggcggccatc
    16021 tggcggtggt cgggcccagc ggcatcggaa aatccacgct ggccgcggtc atcacaggcc
    16081 tgatgcgtcc gcgcgacggg acggtcgaga tcggcggcgt ccgcgccgac caggtcgatc
    16141 cctccgcgcg cgtgctgatc ccgcaggagg cgtacgtctt ccgcggcacc gtccgcgaga
    16201 acctcggtta cctcacgcgc gacgcggaac caccgttcac gcaggccatg gagaggatcg
    16261 gctcggcgga cctcgtggcc cgcctgggcg gcctggacgc cgaactcgac cccggtgcgc
    16321 tctcggcggg ggagcggcag ctgatcgcgc tgacccgcgc ctacctcgcg cccgcccggc
    16381 tggtcgtcct ggacgaggcg acctgccacc tcgaccccgc cgccgaggcc cgcgcggaga
    16441 cggccttcgc gcgacgcccc ggaaccctga tcgtcgtggc gcaccggatc agttccgccc
    16501 gccgggccga ccgcgtcctg ctcatggacg gcacgcgccc ccaccacggg acgcacgacg
    16561 acctgatccg cagctcaccc ccgtacgcgg ccctggccgg acgctggcgc cccgcacggt
    16621 gacaccgccc ggaggtggcg aaaccatgag atatcccgag gccgaacgcg ggcccgtcat
    16681 cgacgtcctg cacggcgagc gcgtcgccga cccctaccgc tggctggagg atccggccgc
    16741 gccggacacc cgcgcctggc tggacgccca ggacgagctg taccagaagc acatcgaccc
    16801 cgaactccgg cggacgttcc gccgccgcgt cgtcgaactc gccgacaccg gaagcgtcag
    16861 cgcccccgtc tggcgcggcg accggcgctt caccctccgc cgcgtcgcag gtcaggagca
    16921 cgcggtcctg cacgtcgcgg acggcggcga gcccgagcgg acgctcctcg acccgaccgt
    16981 gctcgacccg tccggcacga cgacgctcga cgcgtggcgg tccgacccgt ccggacggct
    17041 gctggcctgt caggtgtcgc ggggcggcac cgaacgcgcc gaactcctcg tcctggacgt
    17101 cgagaccggc gagaccctgg acggcccgat cgaccgctgc cgctactccc cggtggcctg
    17161 gctccccgac ggaaaaggct tctactacgt ccgcgccgag ccgggcgacg agacgcgacg
    17221 ccgcgtccgc ctccacctca tcggcgagcc acccgagcac gacacacccg tcaccgaacc
    17281 ggccacgtcc cacggcgtgg gcatcagcgc ggacggtcac tggctcgtca tctccacggc
    17341 ggacggctcc gacccccgca acgacctgta catcgccgac ctgacgaccg ccacgcacca
    17401 gctcaggccc gtccagcagg acgtggacgc ccgagccgcg gccgccatcg gcccggacgg
    17461 ccgcctctac atcgtcaccg accgggacgc cccccgcgtg cgcctctgcg tcgccgaccc
    17521 gaccaacccg tccgactgga ccgaactcat cccggaggac aaggaagccg tcctctccga
    17581 cttcgccttc ctggacggcc tgatcgccat cacccgcatc cgcagcggaa cgtccgaact
    17641 gtcgcttcac gacgcgcgca caggagaacg gcggcgcgac gtccccctgc ccagccccgg
    17701 catactcggg ccgctgtcca cccgtcccgg cggtggacgc gagttgtggt tcacccacag
    17761 cggcatggcc acgcccgaag ccgtctggca ttacgacacc agcgacaaca gtctcaccct
    17821 ctgggaaccg tcccctagcc ccatcgtcct gccgccgctg gagacgcacc agatcacctg
    17881 cacctcggcg gacggaaccc ccgtgcgcgt cgacgtgatg gcccgtcccc accagggccc
    17941 agaccctcgc ccggccatcc tgtacggcta cggcggcttc ggcatcccgc tcaccccgtc
    18001 ctacgccgcg gacgcgctcg cctgggtgga cgagggcggc gtcctggcga tcgcccacct
    18061 gagaggcggc ggcgaggacg gcacgacctc gcaccgcgcg ggcatacaag gccggaaaca
    18121 gcgcgtcttc gacgacttcc tggccgccgc cgaggaactc gtctccaccg gctggacgtc
    18181 ccccgaccgg ctcgcgatct ggggcgagtc caacggcggg ctcctcgtcg gagccgcgct
    18241 cacccagcgc cccgacctgt tcgccgccgc cgtctgcgtc gcgccgttgc tggacatggt
    18301 ccgctacgac ctgtccggca tgggcgcgat gtggcacggc gagtacggct ccccggccga
    18361 ccccgaggcg ttcggctggc tgcgcgcgta ctcgccgtac caccacgtcc acgagggcac
    18421 cgcctacccg gcgaccctct tcgcggtctt cgacggcgac tcccgcgtcg acccgctcca
    18481 cgcgcgcaag atgtgcgccg cgctccagtg ggcgacggcc ggcgaccgac ccgtcctgct
    18541 acgccgggaa tccgacgtcg gccacgcgtc ccgctccgcc ggacgctcct acgacctggc
    18601 cgccgacctc ctggccttcg tcaccaccca gacaaccccc tgaccagggg cgtcaccggc
    18661 ccggacgcgg cgaccgctgc gtccggggga cgacgccccc gagccagccg ttctcctcgg
    18721 cgatggcgac cgcctccaga cgggtgcggg cgccgacctt ggtcacgatg cgggccaggt
    18781 agttccggac ggtcccggtc gcgaggaaca gcgaccgcgc cgtctcggcg acggtcgcgc
    18841 ccttggcggt ctccctgagc acctccagtt cgcgcggggt cagcggactt cgggacgtgg
    18901 cgagctcggc gtaggccatg tccgcgtcga tgacacgctc gccgttcgcg acgtcgcgga
    18961 tcgcctggat caggcgggcc ggcgaggtgt ccttgagcag gaacccctcc gcgcccgcct
    19021 cgaccgcccg gcgcagatcg ccgggccgcc gtcgttcggc catgaggatc acgcggcatt
    19081 ccggcagcag ggtgagcagc cggaaggtcg cgtcgacacc gtcgagatcg ggcaggccga
    19141 ggtccacgag cgcgacctcc gggcggcagt gcgccgccgt ggccagcagc ttgcgggcgc
    19201 agtccacggt ctcgacgacg cggatgtccg gttcgccgtc cagaagggcg accagaccac
    19261 tacggaacag atggacgttc tcggcgagga tgacgcgggt caccggctgg gccccgggag
    19321 gggggcctgg cgtgacaggg agatcggcgc tgatctgtgg aaagcgggca gggcacgtcc
    19381 gggctggagg acgagggtca tggcttcgcc ttggtgtttg gactggggcg cggcagacgc
    19441 cagcgtgctg gagaagcctc gggccgtcaa atgcgatatg tcggaattgg tgccgtcctt
    19501 atacccgtga ggtgagtatt ttcgagcccg tggtggcgca gagtgtccgc gcgcacacgc
    19561 atgacctccg gcgatcacgc tccgacgacg aaggatcccc tggtggggcc cccggcgtcc
    19621 gcttccggcc acagatttga tacccgtcgg tatcccagga cgagaggaat tgtccttggc
    19681 aaacagacga ctccgcctcg gtcaggacac cttaacgccc attcggaaag cccgcctcat
    19741 ggtcttttat gggcccgccg agaagcctcg gaacctactc ctgaggcagg ctggccttgg
    19801 ctttctcata gccgcccgtg ggagcgttct cgtccttggc gtagacgagg tggacgacgc
    19861 cggtcgagaa cggggtggaa ctcagcaatg tcagcggcaa cggcgcgtcc gcgtcctcga
    19921 acagccgcat ccccttccgc accgcgatcg gatgcaccag caggtgcagc tcgtcgagca
    19981 gccccgcctc cagcagccgc cggacgaccg agaccgaccc gctcatcgcg atgtccccgc
    20041 ccggcccgtc cttcaacccg gcgacggccg ggacgagctc cccgcgcagt acctcggagt
    20101 tccgccaggt gaactcgagc tcctgccgcg acacgacgat cttccgcgcg tcgccgagcg
    20161 ccttggccat ccccgcgtcc tcgccgcccg ccgcctcccg ctcgggccac gcgcccgcga
    20221 aaccgtcgta ggtcctccgc ccgagcagga gcgtgtccgc gctgccgagc tgcgccgaca
    20281 ccgcctctcc catctcctcg ttgaagtagg ggaagtgcca gtcctgcggg tcctccacga
    20341 ccccgtcgag cgcgatgaac agaccggccg tgatcttccg catgagtctt ctcctccagc
    20401 tgacgacgtt ctccccaaga gaccgtcccc agcggcgaat ctcatcgaac ccacccgaag
    20461 gtctcgccgt ccgactgatg tggatcaccc gaccccggcc cctgccgctc ctcttcctcg
    20521 acgtcgacgg cccgctcatc cccttcggcg ccgcgacccc gtaccccacg ttcgagcccg
    20581 agggcgacaa cccgttcctg ccccgcgtcg accccgccct cggcccccgc ctcggcgcgc
    20641 tgccctgcga actggtgtgg gccaccgcct ggacgtccga cgccaacgac ctggtcgcgc
    20701 cccggctcgg cctgccgcac ctgcccgtcg tccactggcc cgcgccgtcc gaccaggacg
    20761 acctggacga gcaggccgga ctccactgga agacccggca cctggtcacc tgggccgccg
    20821 gacgcccctt cgcctgggtg gacgacgaac tcaccgaaac cgaccgcgcc tgggccgccg
    20881 cccaccaccc gtccccggcc ctgctccatc acgtcgacgc cacccgcggc ctgaccctcg
    20941 ccgacttcac caccctcacc cactggctga accaccccca gccccaaccc tgagcccgcg
    21001 ggcgcccgac tcgcgggcgc ctgcggtgtc acacgcgggt gttcagctgg ctgatggccg
    21061 cggtgatgcc cttcttgtcg taggcggtga tgggcatggt ggagccgtgg gcgtgccgga
    21121 cgacgccctg cgcgtcgatg aggacactgc ccgactgccg catcgagccg aacatcttct
    21181 tcgacaaccc gacgctctcg tgcggaacgc ccccacgtcc gacgagcacc gggaacggaa
    21241 cgccgcgctt cgccttccac gccctggcga ccgcgcgatc ctccggcacc gcgatgaaca
    21301 cctggacgcc gtccgccgcg aacgtgtcgc gcgaccggac gaggtcctgg acgtgccggt
    21361 tgcagaccgg gcaggacgtc gaccgcatga agaacaccag cgcggcgcgg tcggcctcca
    21421 gagcggccag gcgggtggcc cgtccgtcgg tgtcctcaag tagaacgtcc ggcgcgggcg
    21481 atccggttcc gagcatggcg aactccttaa cgtgcgtgag tggaatcggg gccgacctgc
    21541 ccgttcaggc tgaggcgcag cctggtgcgg gcccggtgga ggtgggactt catcgcgggg
    21601 gtgctcagcc cgagccggtc cgcgaccgtc cgtccgggat atccgaggac gtcccgcatg
    21661 atgagcaccc ggcgctggac gtccggaagc tcctggatcg cctgcgcgac gcgctcggcc
    21721 tccagccgcc ggatcgcctc gtcctcggcg gacgtcacga gatcgggctc gatctcctcc
    21781 ggctcgacga ccagggaccg ggcccgacgc agacactcgt tccggacgat ccggaacatc
    21841 cacgaggcca gtgccccggt cgcgcgcagc gagccgatct tccggtaaag gatgatcagc
    21901 gcctcctgtg cggcgtcctc cgcgtcctgc ggcgtcgcgc acaggtgctc cgcgaaccgc
    21961 cggacgtgga cgtgcgcgcc gtcgagcacc gccacgatcg acgcgcggtc acccgcctga
    22021 gcagccgtga tgagctgcgc gctcgcccag gtgcgatccg tcatgccctc ctcctccagg
    22081 tcggccgaca cccataagag gccgccacgt cccaaaagga ttcaccccac ctgagcgttt
    22141 tcaccccacc tgggctccgg tgaccagcat ccgcctgacg gcggcgtcca ccagatcgtg
    22201 cgcctcccgc tcggtgaaga tgtccggcag cgtgaggcgc tcgaggatga gccagttcag
    22261 cgccaggtac aggagcagca cggacgtcga gtccccgggc aggtcggacg cggcctggtg
    22321 ggcgaggttg gcgtcgatgt cctcgcggat ccgcttcgtc agcacctcgc gcagctccgg
    22381 ccgccgcgtg gactccagcc gcagctcgag cagcgcgaga taccccgagt tgaacgagct
    22441 gacccggttt accacctcgt gcatgagctc ggagtaacgc gcctcgtcct gcacgccctc
    22501 cctgctccgg gccatggtcg cctcgtcggg cagcagccgg tcatagatgc gcccgccgat
    22561 ctgcgtgaac aggtcgtccc ggttggagaa gtagttggac gcggtgcccg cgggcacctc
    22621 cgcctgcgcg tcgacggccc ggaaggtcag cccgcgcgcg ccctcccggg ccagcacctc
    22681 gatggccgcg tcgatcaacg ccagccgccg ctcctggttc ttccgcacgt tgacaccact
    22741 ccatc
//
