LOCUS       NZ_AZXF01000022        23657 bp    DNA     linear   CON 21-OCT-2024
DEFINITION  Nocardiopsis sp. CNT312 B042DRAFT_scaffold_16.17_C, whole genome
            shotgun sequence.
ACCESSION   NZ_AZXF01000022
VERSION     NZ_AZXF01000022.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Nocardiopsis sp. CNT312
  ORGANISM  Nocardiopsis sp. CNT312
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 112486)
  AUTHORS   Jensen,P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R41043
            investigation_type                :: bacteria_archaea
            project_name                      :: Nocardiopsis sp. CNT312
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi14643
            Funding Program                   :: DOE-CSP-ICBG 2011
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000515115.1-RS_2024_10_21
            Annotation Date                   :: 10/21/2024 21:26:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,296
            CDSs (total)                      :: 4,234
            Genes (coding)                    :: 4,144
            CDSs (with protein)               :: 4,144
            Genes (RNA)                       :: 62
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 23 of 90
            Pseudo Genes (incomplete)         :: 74 of 90
            Pseudo Genes (internal stop)      :: 5 of 90
            Pseudo Genes (multiple problems)  :: 12 of 90
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:21:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 88829
            Orig. end                         :: 112486
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AZXF01000022.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..23657
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23657
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23657
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(93..110)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.51"
                     /tool="antismash"
     gene            118..789
                     /locus_tag="B042_RS0111410"
     CDS             118..789
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017596735.1"
                     /locus_tag="B042_RS0111410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_028648403.1"
                     /transl_table=11
                     /translation="MCSAPRRPPEPEEDLTARARIRGAAIACFGQKGFGVPVRTIAERA
                     GVSPALVMHHFGSKAGLRRACDEHVRNLVYEIKKDSVTTADQRTFLDRFAGMDEYAPYV
                     AYFVRSFQAGGDIAHALFEHMVEDIENYLAAGEEAGTVRPSRDPAARARFLAMGHIGSL
                     QMFLTMHFPGPDIDFREVMRAWSERITLPTLEIYSEGLFTNRAMLDAYLLYVGDPPEEE
                     S"
     gene            832..1752
                     /locus_tag="B042_RS0111415"
     CDS             832..1752
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017608392.1"
                     /locus_tag="B042_RS0111415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_028648404.1"
                     /transl_table=11
                     /translation="MSAPAIEVSGLDKYFGQFKALDGLDLTVEPGQVAGFLGPNGSGKS
                     TTIRVLLGLLRSDGGTARLLGGDPWKDAVTLHRRLAYVPGDVSLWPNLTGGQAVDLLGR
                     LHGRADRTRRKALLERFELDPTKKARTYSKGNRQKVALVAALASDAELLILDEPTSGLD
                     PLMESVFTDCVHEAKRQGRSVLLSSHILAEVEKLCDTVTIIRKGRTVESGTLNDLRHLT
                     RSTVRATTEGDPSALAGLTGVHGLNVEGADVTFDVDNDHMDQAFRALADLGLRSLVSNP
                     PSLEELFMRHYGDELAALNGEGAAK"
     gene            1749..3347
                     /locus_tag="B042_RS0111420"
     CDS             1749..3347
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017581877.1"
                     /locus_tag="B042_RS0111420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_028648405.1"
                     /transl_table=11
                     /translation="MSTFTGTGRLILFILLRDRIRMTVWTLSLVGSMFMVIPTLADMFA
                     TPEQRMARATIMETPTGIVFGGPGYGLEEYGLGAMVANEMTQSLLVALAVMGILHVVRH
                     TRAEEESGRAELLRANVLGSSAQITAALVTNALVSGAIGALITVSMVVNGLPLADSAAY
                     GAGLALAGVVFGAVAAVCAQVSGYARGASGLAFLVIGVLFMLRVVGDIAERGGSAPSWF
                     SPFAWVQQTRAFDDLRWWPLALYVLVIAILFAVAYVLADRRDLGAGLVAARPGPAGAGP
                     LLNGVLALHLRQQRASIIAWTVAVALFAFAFGTLVTEIDGMAEQNPEIMARMGLTGEGM
                     IEAFLGVLTLYIVMPTAAFAVLSVLRARAEEDSGRAELVLSSAVGRLRWMGSTVLVSAL
                     SGMVMMFLGGLAMGVGAASATGDTAWIRVVAEAGAAQIPVVLMFAGLTTLFLGAAPRLV
                     GLVWAWFAYGLFVTIFGLLMDLPDWMVHVGPFEIVALLPTEEFAPVPYLAVLAGAGAAA
                     AVGLAGFRRRDLVTA"
     misc_feature    4670..4682
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            4742..5632
                     /locus_tag="B042_RS0111430"
     CDS             4742..5632
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573789.1"
                     /locus_tag="B042_RS0111430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_051415637.1"
                     /transl_table=11
                     /translation="MAAAQQRSQEVEMPEGTPVHGSPARRHYLISQLKRLRTRTGLSQE
                     EAAEEMGWHKSKVSRMENGKWKRLSGPEIDALCRFYQAPDDLREELTRIAKAASRSRAA
                     WWNAYEDVPGGAYYPLEYEADQILEYTIGLFGGLAQHPDYIRALMARGVVPDESERERR
                     VQVRLERTRNILDRPNPPQMWWIIDEPVLTCQVGGPDVMRTQLEHVLELSEHPRIDLQV
                     LPQSQGMSLNYGFCLLRLGDDRVGHVDVPPQGLLFDAPDDIEHHVLRFHHLQAAALPLD
                     HSRELIRRRITELNP"
     gene            5647..5847
                     /locus_tag="B042_RS22900"
     CDS             5647..5847
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155484.1"
                     /locus_tag="B042_RS22900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_036554721.1"
                     /transl_table=11
                     /translation="MNTTPGNGYSPAPHGWHVSSHSNEAGTCVEVAQGPVTGVRDSQHP
                     DHGALFFPADAWTGFITGVSM"
     gene            complement(5955..6767)
                     /locus_tag="B042_RS0111440"
     CDS             complement(5955..6767)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="B042_RS0111440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_197024268.1"
                     /transl_table=11
                     /translation="MESAHPSARATTDHRVLADSAYRDDRDLGARQRLYDYQRPVFDLP
                     GLALDRLADRGGVWADVGCGNGRYLHRVRTDRPDVRAVGLDVSASLLGALQAPVVCADA
                     ARLPLGERSVDAVLAMHMLYHLPDPARGIAEFARVLGPGGRVVASTNSRADKHEIDRLW
                     SAAAGTVLGTGRGPRRIKLSEHFPLEDAGEAFGAHFARVRVEELSGVIEVDTPEPVLAH
                     LGSYRAWADQAGVPFEAALEQAARDLEERLRRGPFTVTTRQGLVIADR"
     gene            complement(6773..8050)
                     /locus_tag="B042_RS22905"
     CDS             complement(6773..8050)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B042_RS22905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_155989032.1"
                     /transl_table=11
                     /translation="MVQAVDARDARQVLRLLSRHAPDLTHEALANMCQVSQSTITRAIS
                     GQGLTRASTVHTVLTSLGAPIPRPPAAPRNPTRTERGAPRSEEGELDRTLARDAHRTLR
                     QTRAVLAKAMHEPALDLLEADIGRLARHYVSHPLADLYTEIKSLRDDTFALVETTSHPD
                     QIRRLHIAAARLAGLQAHVCLDLGQYAHADTNADAAWALATSVHEPGLRAWVRSLHSLI
                     AYWDGRYRDARHAAEDGLTHRVTDSNLARLHALRARACAAQGDHRQALAAIGAAHEHSR
                     QHLLPGVFGFPEAKVHAYASSSLLMFATPRDRHRSVEHAHRAIRLYTEASALDRSFGDL
                     LAARLDLASAHIHAREPDAALEQVQVITAAPPQHRTASITQRAQRLARLVTATTDAEAA
                     RRIHAHVTEFCRHPGPLAARAPVAAR"
     misc_feature    complement(8108..8119)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     misc_feature    8185..8194
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.45"
                     /tool="antismash"
     gene            8424..9701
                     /gene="fxlM"
                     /locus_tag="B042_RS22910"
     CDS             8424..9701
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618483.1"
                     /locus_tag="B042_RS22910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_051415639.1"
                     /sec_met_domain="PCMT (E-value: 5.1e-41, bitscore: 133.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDAATVDSAQAAHLREELVARLVDDKTIVSPGVEEAMLAVPRER
                     FAPGTPLEEVYHPYNAVITKTDGSGVQLSSVSAPQIQAMMLEQARLRPGHRVLEIGSGG
                     YNAALIAEIVGPSGEVTTVDIDPEVTDRTRSLLPENGYDRVRVITADAESGIPEHGPYD
                     RIIVTVGTWDIPPGWVENLAEEGRLVVPLRMRNLTRSIGFAKAEDRLVGDSAHVCGFVP
                     MQGAGEHRETLLLVNGTEEIGLRFDDETPADPQRLDNAVRTPRAETWTGATALLQEPIG
                     VLQLYLATHLPGFCTMAVDPELDTGLVAPSNRRSSMAAVAGGDFAYLATRRTPDDTSVE
                     YGVHAFGPGSEAFAETVAEHVRAWHRDQRGGPGPRIEVFPASTPAERLTGEAVITKRHC
                     RITFSWPPASDQGRGQVFPPTSTQGE"
     gene            9707..9907
                     /locus_tag="B042_RS0111455"
     CDS             9707..9907
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564549.1"
                     /locus_tag="B042_RS0111455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_028648408.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 3.1e-19, bitscore:
                     61.3, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGSTAGGSAALAERPAVSEDDFALDVRVVVATHPVGKLMCNTGD
                     GCGNTCQGTASACNSYVSDPV"
     gene            10001..13048
                     /locus_tag="B042_RS0111460"
     CDS             10001..13048
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618481.1"
                     /locus_tag="B042_RS0111460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_028648409.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.2e-200,
                     bitscore: 658.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-17,
                     bitscore: 56.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.8e-17, bitscore:
                     55.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKRSPRAYEWSGGALLRASTSPEDLDVPEDLVSEHSPARGLEWL
                     ARLWERREVRDALSAANPGLCSQITGALSGRRLDDRRVRKTLLSVVSYLARWERPTPFG
                     LFAGTAPVSIGAAAHTVWGDGHRVALRADSEWLSDIIARLHRCPALVERLHVAANNTGQ
                     VRGARYVVPGQSADGHSLRAAPVEVSVRHSPPVALALEIARTPVRYERVREHLTLGFPH
                     VAGEQITALLEGLIDQHLLLTDLWAPMSCTDALAHLCDTLAAVRAENIDEIADLVADLH
                     TVRSRLAHPVRHTAWSERVPVLERMRELSDVAPVPVIADTVLDCRLALPERVVRTVEEA
                     ADVLTRLTPEPFGSAQWRDYHARFRARYGAGAVVPVLELVADSGLGWPAGYLGASRGRP
                     PRMLSERDHTVLRLVQQAQAAEEGEIVLTDSTVTALGPGSGEEVLPPPRVEVCVQIHAP
                     TPRAIEKGAYTVAVTGAPRPASSMAGRFAHLLPEEDHEALAHGFRSPEAGTVTAQLTFP
                     PRKRRNENITRTSRLLPHIVPLAEHHPPGPDVIGVDDIAVSADAHRFHLLRLSTGQRLE
                     LRVPHALEAGTHTPPLARFLAEVANARHAVYGGFDFGAAAQMPFLPRVRYGNIVLSPAR
                     WRLDARDLPRFDQHRPVWDEGFDRWRARWHVPDRAALVEHDRHLPLDLSHPVHRHLLRQ
                     RLAAHGQVELRETATREQVAWLGRSHELLFPLRASGSGSVHRTGPVRPVCVDAAHLPGS
                     SVTRAHLYAHPDRFDEILTGHLPALTSLLPDSALWWFRRHRDLSRPDADRYLELYLRLG
                     PEHSGGSAVEQVHAWARDLRHQRLLAHLELAAYEPQTGRFGHGEAMEAAEAVFAADSAA
                     ALAQIRAAQGQGVDPLALTAASIVDLATGFTDTPETGLVWLTQDLAHTPGPVDRAVRSR
                     ALDLASPAGESLLRLDGVAEAWAERASALSGYRKRLAAERDPHSVLRSLVHLHHVRALE
                     IGPDSEAATIRTARAIALFHTEWRSP"
     aSDomain        10466..10744
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B042_RS0111460_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="4.70E-18"
                     /identifier="RREFam001.1"
                     /label="B042_RS0111460"
                     /locus_tag="B042_RS0111460"
                     /protein_end="248"
                     /protein_start="155"
                     /score="56.7"
                     /tool="antismash"
                     /translation="VAANNTGQVRGARYVVPGQSADGHSLRAAPVEVSVRHSPPVALAL
                     EIARTPVRYERVREHLTLGFPHVAGEQITALLEGLIDQHLLLTDLWAP"
     gene            13045..14274
                     /locus_tag="B042_RS0111465"
     CDS             13045..14274
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017618480.1"
                     /locus_tag="B042_RS0111465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_036554723.1"
                     /sec_met_domain="LANC_like (E-value: 8e-44, bitscore:
                     142.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVPVPSPAAPAAEAAERIAARLDVPRPATDPWMDQSLAQGAAGT
                     ALLHIERAHTGRGTWQHAHRWVTAVAATQISAADTTGLFLGAPAVAFVLRAASGSDRYA
                     EALAALDEHVAELAHRRSRAAMARIGRGELSTFGEYDVFYGLTGIGAYLLRSAPEGNAL
                     ESVLRYLVALTRPMPGEFEGRPGWWVSHDPHRGSSAHFAQGHGNLGVAHGITGPLLLLS
                     QAQRRGVTVDGQAEAIETVCGHLERWCQPGERGPWWPEHLTVHDLGEGVPRQPGPARPS
                     WCYGTPGIARAGQLAAAALGDRDRQAFFENALDLCLSDPEQMSRVTDAGLCHGWAGVYQ
                     TVWRTARDAATPGLDRHLAGLADRLVEHVDRRPGTDDFLEGDAGAALALMTAERGTDPE
                     SGWDSCLLID"
     gene            14292..15239
                     /locus_tag="B042_RS0111470"
     CDS             14292..15239
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564545.1"
                     /locus_tag="B042_RS0111470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_231493939.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.2e-43, bitscore:
                     139.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSGEAVLAVLRGTPVAEAAAASGADPVAVAADVALFCRAGHQA
                     LEARDPWWQLYLEFADWHRADGVAAERLVPTLRLLESEAGLSWWYIRKHPCWRLRLRTP
                     DREERMRVRIETVLNTLVRAGHLRRWWTGVYEPESIVFGGPEGMEAAHELFHADSRAVL
                     TVQEQDHPGLGRRELSVLLCSALIRGAGLEWYEQGEVWHRVAQERPLPEDIAEERIRAM
                     AGDVHALLQADVSSGGPLFAAGGAAAVAASWAEAFHTTGRVLGKAARDGSLQRGLRQVL
                     AYHVIFHWNRLGLRPRAQSALAWAARTAVLDRTH"
     gene            15236..15460
                     /locus_tag="B042_RS26515"
     CDS             15236..15460
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF13471"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="B042_RS26515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_255342339.1"
                     /sec_met_domain="PF13471 (E-value: 8.9e-17, bitscore: 53.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRGPLPWHSCLEESVAGTIALALTGHSVRWCHGVMADPILLHAW
                     IEVDGDAVAEPDSTRKCAVLLALPAKENT"
     gene            15457..16032
                     /locus_tag="B042_RS0111480"
     CDS             15457..16032
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013155483.1"
                     /locus_tag="B042_RS0111480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_028648412.1"
                     /transl_table=11
                     /translation="MSDPLIWLRGEKAGIGPLRADLVEEYWRWEQTIPTIVGYNRRTPQ
                     PIETTRLILIEGYDRASDREIRFTVYDLAGSEPVPVGIAQVMTDQPRGNGEYIAAMGES
                     RGKGVGTEATKLVLDYAFHVANMACVWLTVLEPNTGAIRAYEKAGFKRQGIRRNSNVWL
                     GQRVNEVLMDALPEEFEGPSRVKELFQG"
     gene            complement(16056..16535)
                     /locus_tag="B042_RS0111485"
     CDS             complement(16056..16535)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017596738.1"
                     /locus_tag="B042_RS0111485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="membrane protein"
                     /protein_id="WP_028648413.1"
                     /transl_table=11
                     /translation="MVETALAFAVALLSGLVPVLNIEVYLVGAAVAVDSGPLLGTAMAV
                     AAGAGQTLGKLPYYYAGRGTLSLRWMHRRKNDPGRWSERVARWRRSAEARPLWGAGLVA
                     LSSFASVPPFMAVCVLAGTVRMNVVVFSAITMVTRTARFLLLVLAPGWAMDLLPG"
     gene            complement(16562..17659)
                     /gene="rlmN"
                     /locus_tag="B042_RS0111490"
     CDS             complement(16562..17659)
                     /EC_number="2.1.1.192"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0016433 - rRNA (adenine) methyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0030488 - tRNA methylation [Evidence IEA]"
                     /GO_process="GO:0070475 - rRNA base methylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rlmN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017571943.1"
                     /locus_tag="B042_RS0111490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="23S rRNA (adenine(2503)-C(2))-methyltransferase
                     RlmN"
                     /protein_id="WP_028648414.1"
                     /sec_met_domain="PF04055 (E-value: 3.5e-18, bitscore: 59.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAELTFVAPRRAQPPRHLADLTPDERAEVVTGLGEKPFRAKQLA
                     QHYFGHLESDTSAMTDLPESSRERLGEALLPTLLTPVRHITCDNGMTRKTLWKAFDGVL
                     FESVLMRYPDRVTLCISSQAGCGMNCPFCATGQAGLTRNLSTGEIVDQVVASARDLARG
                     EVAGGPGRISNIVFMGMGEPMANYKRVLQTVRHITDPVPRGLGISQRGVTVSTVGLVPA
                     IDKLIAERMQVRLAISLHAPDDELRDELVPINTRWKVQEVLDAAWRYAGTTGRRVSIEY
                     ALIKDINDQAWRADLLGRLLKGHLVHVNLIPLNPTPGSKWTASRPEDEREFVRRLESHG
                     VSVTVRDTRGQEIDGACGQLAAAEN"
     misc_feature    complement(17715..17728)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.06"
                     /tool="antismash"
     gene            17852..18940
                     /locus_tag="B042_RS0111495"
     CDS             17852..18940
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567704.1"
                     /locus_tag="B042_RS0111495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="suppressor of fused domain protein"
                     /protein_id="WP_028648415.1"
                     /transl_table=11
                     /translation="MSGINVLLDEISPYQSRRVVVECDSRTTAAYLLDARGRIRVPVWL
                     ANHEPAPASDEEGGSFEGRAPLMPEAYTKHPQGLPRFDPSALRAVWFEEGDGVALVDEQ
                     GLLAVIPGWAEADSGLPGYAREAVGRSAYAWELDSVRGHLWPRVVHAEAYWDWRRAAGA
                     WRGVQRTVLGHLNRRVGEPGHYWDVSDGHPPLLRLSERPPTAERPFTVLSTVGMCGQRM
                     PTLDRYMADTSRHARVELALATTMPAHRAARIFRWIGAFPWRAVTWFGTGHTVKWLDNP
                     EDRAMRGEAGAVLLLEDPVPLAAAGTGQAPPDLSGLTFQGDPVRWLWIVPITRPEHLFA
                     KEHDSAALVEKLSAEGRGWVLG"
     gene            complement(18937..19311)
                     /locus_tag="B042_RS0111500"
     CDS             complement(18937..19311)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567706.1"
                     /locus_tag="B042_RS0111500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_028648416.1"
                     /transl_table=11
                     /translation="MRGLGELEAAIMDALWRSEEPLSVRRVRESMVYDREVAYTTVMTV
                     ANILFHKGLLDREKSGRAWVYWPRETHAEYTARVMDEVLNAGPDPGATLVSFVERFSDE
                     DMARFHHLLAQARDRRGIAS"
     misc_feature    complement(19593..19602)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     misc_feature    19611..19627
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    19615..19629
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.32"
                     /tool="antismash"
     misc_feature    complement(19619..19632)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.78"
                     /tool="antismash"
     misc_feature    complement(19816..19829)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            19890..23504
                     /locus_tag="B042_RS0111505"
     CDS             19890..23504
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542536.1"
                     /locus_tag="B042_RS0111505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /protein_id="WP_036554725.1"
                     /transl_table=11
                     /translation="MSSEASQPLTDFGPNEWLVEELYQKYLTDPDSVDKAWWNFFADYK
                     PADTGAQGGGAAKAAKAKKSKAPAAPAPKKTAKTTEPESDEVKRERLRGAPARTATNME
                     SSLALPTATSVRAVPVKLLFDNRIVINNHLRRARGGKVSFTHLIGFAMVRALESMPEMN
                     HSYVEVDGKPGVAKPDHVNFGLAIDLQKSDGSRQLVVPSIKGADEMDFAEFWSGYEDLV
                     RKARNNKLGVPDFQGTTISLTNPGGIGTVHSVPRLMPGQGTILGVGAMEYPAEFQGASQ
                     DTLSELGISKVMTLTSTYDHRIIQGAQSGEFLRRIHQLLLGEEGFYDEIFRSLHIPYEP
                     VRWVQDIHVNTATQLDKATRVQELIHAYRVRGHLMADTNPLDHEQRRHPDLDVLQHGLT
                     LWDLDRSFPTGGFGGKQVMKLRDMLGVLRDTYCRTVGIEYMHIQSPEEREWIQSHVERE
                     HEKLDRDEQLHILHRLNSAEAFETFLQTKYVGQKRFSLEGGESLIPLLDGVIARAARAE
                     LDEAVIGMAHRGRLNVLANICGKSYGQIFGEFEGNLDPRSAHGSGDVKYHLGTEGVFET
                     KDGERIAISLAANPSHLETVDPVAEGIVRAKQDLLNKGPHGFTVLPILIHGDAAFAGQG
                     VVAETLNLSQLRGYRTGGTVHVIVNNQVGFTTSPSDSRSSVYATDVARMVQAPIFHVNG
                     DDPEAVVRVAHLAFAYRQAFNKDVVIDLVCYRRRGHNEGDNPAFTQPLMYDVIDSKRST
                     RKLYTEALIGRGDITVEEAESALRDFQSELERAFSETREVEKRPVEPGAVVKPEVFTEG
                     RLDHSAVETAISAETVKRVIDTQVNLPEDFTAHPRLAPQLQRRAQAVESDTVDWATGEL
                     LAFGSLLLDDHPVRLVGQDSRRGTFGQRHATLMDRETGASYTPLKRFDSGTTRFHVHDS
                     LLSEYAALGFEYGYSLTRPEALVMWEAQFGDFVNGAQSVIDEYISAGEQKWGQRSSVTM
                     LLPHGYEGQGPDHSSARIERFLQLCAQENMTVAMPTTPASYFHLLRWQAKSPLERPLVV
                     FTPKSLLRLKAAVSAAEDFTTGHFRPLITDDSIAPEKVRRVVLCSGKIYYDLDAARRKS
                     GDKHTAIIRTERLYPLPIEEIREQLKAYPKAGEVLWVQEEPANMGPWPFVALVFSEQLD
                     RPFTRISRPASSAPAAGSAKRHEAEQRALVDTVFPPAD"
ORIGIN
        1 ccgcggcgtg cgtccaccga gtgtacgggc ccgcgcgtac cccccgcccg gcgttcgtcc
       61 gacaggaccc gccctacccc ttgccaaggc actgaacaag catttagcat gctgaacatg
      121 tgttcagctc ccaggaggcc tccggagccg gaggaggacc tcaccgcgcg ggcccgcatc
      181 cgcggcgccg ccatcgcatg cttcgggcag aagggattcg gcgtcccggt gcgcacgatc
      241 gccgagcgcg cgggcgtctc ccccgccctg gtcatgcacc acttcggttc caaggccggg
      301 ctgcgccggg cctgcgacga gcacgtccgg aacttggtct acgagatcaa gaaggactcg
      361 gtcaccaccg ccgaccagcg gacgttcctg gaccggttcg ccggcatgga cgagtacgcc
      421 ccctacgtcg cctacttcgt ccggtcgttc caggccggcg gggacatcgc ccacgcgctc
      481 ttcgagcaca tggtggagga catcgagaac tacctggccg cgggcgagga ggcgggcacg
      541 gtccgcccca gccgggaccc ggccgcgcgc gcccgcttcc tcgccatggg ccacatcggc
      601 tcgctccaga tgttcctcac catgcacttc cccggccccg acatcgactt cagagaggtc
      661 atgcgggcct ggtcggagcg gatcaccctg cccacgctgg agatctactc cgagggcctg
      721 ttcaccaacc gcgcgatgct cgacgcctac ctgctgtacg tgggggaccc ccccgaggag
      781 gagtcctgat cctccctcgc ccgcgtacac gatcaccccc aggagagaga catgtccgca
      841 cccgccatcg aggtcagcgg cctcgacaag tacttcggcc agttcaaggc cctcgacggc
      901 ctcgacctca ccgtggagcc cggccaggtc gccgggttcc tgggccccaa cggctcgggc
      961 aagtccacca ccatccgcgt cctgctgggc ctgctcaggt ccgacggcgg caccgcccgc
     1021 ctgctcggcg gtgatccgtg gaaggacgcc gtcacgctgc accgccgcct ggcctacgtg
     1081 cccggcgacg tgtccctgtg gccgaacctc accggcggcc aggccgtcga cctcctcggg
     1141 cggctccacg gcagggccga ccgcacgcgc cggaaggcgc tgctggagcg gttcgagctc
     1201 gaccccacca agaaggcgcg cacctattcc aagggcaacc gccagaaggt cgccctggtg
     1261 gccgctctgg cctccgacgc cgaactgctc atcctcgacg agcccacctc cgggctcgac
     1321 ccgctcatgg agtcggtgtt caccgactgc gtgcacgagg ccaagcgcca gggccgctcc
     1381 gtgctgctgt ccagccacat cctggccgag gtcgagaagc tgtgcgacac ggtcaccatc
     1441 atccgcaagg gccggaccgt ggagtcgggc accctgaacg acctgcgcca cctgacccgc
     1501 tccaccgtcc gcgccaccac cgagggcgac ccgagcgcgc tcgccggcct gaccggtgtg
     1561 cacggcctca acgtcgaggg cgccgatgtc accttcgacg tcgacaacga tcacatggac
     1621 caggccttcc gcgcactggc cgacctcggg ctgcggtccc tggtcagcaa cccgccctcc
     1681 ctggaggagc tcttcatgcg ccactacggc gacgagctcg ccgcgctgaa cggcgagggg
     1741 gccgcgaagt gagcaccttc actggtacgg gacggctgat cctgttcatc ctgctccgcg
     1801 accgcatccg gatgaccgtc tggacactct ccctggtcgg ctcgatgttc atggtcatcc
     1861 ccacgctcgc ggacatgttc gccacacccg agcagcggat ggcccgcgcc acgatcatgg
     1921 agaccccgac cggcatcgtc ttcggcggcc ccggctacgg gctggaggag tacgggctcg
     1981 gcgcgatggt cgccaacgag atgacgcaga gcctgctggt ggcactggcc gtcatgggaa
     2041 tcctgcacgt ggtccgccac accagggctg aggaggagag cggacgcgcc gaactgctac
     2101 gcgcgaacgt gctcggctcc agcgcccaga tcacagccgc gctggtcacc aacgccctgg
     2161 tcagcggggc catcggtgcc ctgatcacgg tcagtatggt ggtgaacggc ctgcccctgg
     2221 cggactccgc cgcctacggc gcggggctgg ccctggccgg tgtcgtgttc ggagcggtcg
     2281 cggcggtgtg cgcccaggtg tcggggtacg cgcgcggcgc cagcggcctg gccttcctcg
     2341 tcatcggcgt cctgttcatg ctccgcgtgg tgggcgacat cgccgaacgc ggcggcagcg
     2401 cgccatcgtg gttctcgccc ttcgcgtggg tgcagcagac ccgggccttc gacgacctgc
     2461 gctggtggcc cctggcgctg tatgtgctgg tcatcgcgat actgttcgcc gtcgcctacg
     2521 tcctggccga ccggcgcgac ctgggggcgg gcctggtggc cgcgcgcccg ggtcccgccg
     2581 gggcgggtcc cctgctgaac ggggtgctgg cgctgcacct gcgccaacag cgcgcgtcga
     2641 tcatcgcctg gaccgtcgcc gtggcgctgt tcgcgttcgc gttcggcacc ctggtcacgg
     2701 agatcgacgg gatggccgag cagaacccgg agatcatggc gcggatgggc ctgaccggcg
     2761 agggcatgat cgaggcgttc ctcggcgtgc tgacgctcta catcgtgatg ccgaccgcgg
     2821 ccttcgccgt cctgtccgtc ctgcgagccc gcgccgagga ggactccggg cgtgcggaac
     2881 tggtgctgtc gtcggcggtg ggccgcctcc ggtggatggg atcgaccgtg ctggtcagcg
     2941 ccctgtccgg gatggtcatg atgttcctgg gcgggctggc gatgggggtc ggcgcggcct
     3001 cggccaccgg ggacaccgcg tggatccggg tggtggctga ggccggggcc gcccagatcc
     3061 cggtggtgct gatgttcgcc gggctcacca ccctgttctt gggtgcggct ccgcgcctgg
     3121 tgggcctggt gtgggcgtgg ttcgcctacg ggctgttcgt cacgatcttc ggcctgctga
     3181 tggacttgcc cgactggatg gtgcacgtcg gcccgttcga gatcgtggcg ctgctgccca
     3241 ccgaggagtt cgcgccggtg ccctacctcg ccgtcctcgc gggggcgggg gccgccgccg
     3301 cggtgggcct ggccgggttc cgccgccgag acctggtcac cgcctgaggg ggccgctcag
     3361 cccggcagga ggtccatcgc ccagccgggg gccagcacca ggaggaggaa gcgggcggtg
     3421 cgggtgacca tggtgatcgc cgagaacacc acgacgttca tccgcaccgt ccccgccagc
     3481 acgcagaact ggagtcggca ccttcgtcac gaagaggttc ccgaatcact caccatgaca
     3541 tgaggtggga acggctgcta cggacacagg tctgcccctg gaacggcggt cctaaaggcc
     3601 gggtcagccg accttcatcg ctccgttcat cgcgatcagc agcgtctcgc cgggcgtcgc
     3661 ccgccctcta cgcgcagagg accacccaac cgttaccagc ccggacacgc gatggcccac
     3721 ctgaatagac cctgaactgc actgataggc gcggaggggt ggccgcaggg cacacctacc
     3781 cgctggcccc cgtgtgggcc cacccgttgg ccctgacgca catcgtgctc actcggcacc
     3841 ccccacaagt ccctccctcc gctggactcg acaccgcacc gcgcacaaca aaccgggggt
     3901 ggtaccggcc cgtgccggta ccaccccaag agcgcgcctg ctctccggtc aggccctcat
     3961 cgcctgccac tggcgcacca gatgggccaa ctcagcgaac tcacccccgc caccaggggt
     4021 cggagaagac acccgagcgg gcacagaagc gtcggcggcg gcaaggagat caccgccgcc
     4081 aagccccgca ggccccaaac gccccggcct cgtacccccg gctccggttc cggggtagcg
     4141 gaagcgctcc tccgcacgca ccagataagg acgcaccccg cgcaccccgt catcgtccac
     4201 acaccacccg agccgcccca gatacgggtt ccgcacacgc cgcacctcaa ccactccctc
     4261 gaacacgccg ctctcgacac aggcacgcgc acccacaccc accggaggct ccggggcggg
     4321 agcggcctcc agacccgccc acacctcccg cccctgcccc agacgcggac ggggccgagg
     4381 cacctccccc ggccgcaccg gcacggccgg gcggcccacc gggctgcaca acaccgcggc
     4441 cagcaccgcc ccgagcaccc accgcacccg cgcaccccaa ccccggcagc gcctggtcgg
     4501 ttatcgccct ggccagccct acggcgaccg gccccggttc cttccacgaa cacacgactt
     4561 ccctcacgtc acatccacct cacccgttct gtgccatcag cgttgaaccg ccgcgttcca
     4621 cagggccatg gcccgtgcgg cgatcgtgcg tccatcatga tttgcaacga cgcaaattac
     4681 aagcgacgca ttccgatagg cgaatattat gtagcgatgt gaatacggtg ggaatgggaa
     4741 gatggcagcg gcacagcagc gatcccagga ggtggagatg cccgagggca ctccggtgca
     4801 cggctccccg gcccgacggc actacctgat cagccagctc aaacggctac gcacccggac
     4861 aggcctgtcg caggaggagg ccgccgagga gatgggctgg cacaagtcca aggtctcgcg
     4921 catggagaac ggcaagtgga agcgcctgag cggcccggag atcgacgccc tgtgccgctt
     4981 ctaccaagcc cccgacgacc tgcgcgagga actcacccgt atcgccaaag ccgccagccg
     5041 cagccgtgcc gcctggtgga acgcctacga ggacgtcccg ggcggcgcct actaccccct
     5101 ggagtacgag gccgaccaga tcctggagta caccatcggc ctgttcggcg ggctcgccca
     5161 gcaccccgac tacatccgcg cgctcatggc ccgcggcgtg gtccccgacg agagcgagcg
     5221 cgaacgccgc gtgcaggtcc gtctggagcg cacccgcaac atcctggacc gcccgaaccc
     5281 gccccagatg tggtggatca tcgacgagcc ggtcctgacc tgccaggtcg gcggcccgga
     5341 cgtgatgcgc acgcagttgg agcacgtcct ggagctgagc gagcaccccc gcatcgacct
     5401 ccaggtgctg ccccagtcac agggcatgag cctcaactac gggttctgcc tgctccgcct
     5461 gggcgacgac cgcgtcgggc acgtcgacgt cccgccccag ggtctgctgt tcgacgcccc
     5521 cgacgacatc gagcaccacg tgctcaggtt ccaccacctg caggcggccg ccctaccctt
     5581 ggaccactcc cgcgagctga tccgccgaag gatcaccgaa ctcaacccct gatgcgaggc
     5641 ctcgcgatga acaccacccc cggcaacggc tactcccccg ctccgcacgg ttggcacgtg
     5701 tcgagccaca gcaacgaggc cggcacctgc gtcgaggtcg cccaaggccc ggtgaccggc
     5761 gtccgcgaca gccagcaccc cgaccacggc gccctgttct tccccgccga cgcgtggacg
     5821 ggcttcatca cgggggtctc gatgtgacgg ggcacccggc gcccccgcgt tctcaacgga
     5881 tgctcagagc gtgctcagaa cgcactcacg agggcgagtg gagggggcgg gcggatccgg
     5941 ccgggcgcgg cccctcaccg gtccgcgatg accagcccct ggcgggtggt gaccgtgaag
     6001 ggtccccgcc ggagccgttc ctccagatcc cttgcggcct gctccaacgc cgcctcgaag
     6061 gggaccccgg cctggtcggc ccacgcccgg taggacccca ggtgcgccag caccggctcg
     6121 ggggtgtcca cctcgatcac ccccgacagc tcctccaccc gcacccgcgc aaagtgggca
     6181 ccgaacgcct cccctgcgtc ctccagcggg aagtgctcgg acagcttgat ccggcgcggc
     6241 ccccgcccgg tgcccagcac ggtgcccgcc gccgcagacc acagtcggtc gatctcgtgc
     6301 ttgtccgccc gggagttggt ggaggccacc acccggccgc cgggcccgag cacgcgcgcg
     6361 aactcggcga tccctcgggc ggggtcgggc aggtggtaga gcatgtgcat cgccagcacc
     6421 gcgtccacgc tccgctcgcc caggggcaga cgggcggcgt ccgcgcacac caccggggcc
     6481 tggagcgcgc ccagcaggga ggcggacacg tccaggccca cggcccggac gtcgggcctg
     6541 tcggtgcgga cgcggtgcag gtagcggccg ttgccgcagc ccacgtccgc ccacactccg
     6601 ccccggtccg cgaggcggtc cagggccagg ccgggcaggt cgaagacggg gcgctggtag
     6661 tcgtacaggc gctggcgggc gcccaggtca cggtcgtcgc ggtaggcgct gtcggccagg
     6721 acgcggtggt cggtggtggc ccgggcggag gggtgagcgg actccatagg ggtcatcgtg
     6781 ccgcaacggg tgcgcgtgcg gccagcggtc ccgggtggcg gcagaactcg gtcacgtgcg
     6841 cgtggatccg gcgggccgct tcggcgtcgg tggtggcggt gacgagacgg gccagacgct
     6901 gggcgcgctg ggtgatgctg gcggtgcggt gctggggcgg ggcggcggtg atgacctgga
     6961 cctgttccag ggcggcgtcg ggctcgcgtg cgtggatgtg ggcgctggcc aggtccaggc
     7021 gggcggccag caggtctccg aaggagcggt cgagtgctga tgcctcggtg tagagccgga
     7081 tcgcccggtg ggcgtgttcg acgctgcggt ggcggtcgcg gggggtggcg aacatgagca
     7141 ggctgctgct ggcgtaggcg tggaccttgg cctcggggaa gccgaacacc ccggggagga
     7201 ggtgctggcg gctgtgctcg tgggcggcgc cgatcgccgc gagggcctgc cggtggtcgc
     7261 cctgggccgc gcaggcgcgg gcgcgcaggg cgtggaggcg ggccaggttg ctgtcggtca
     7321 cgcggtgggt gaggccgtct tcggccgcgt gtcgggcgtc gcggtagcgg ccgtcccagt
     7381 aggcgatgag gctgtgcagg gagcgcaccc aggcgcggag gccgggttcg tggacgctgg
     7441 tggcgagggc ccacgcggcg tcggcgttgg tgtcggcgtg ggcgtactgg cccaggtcca
     7501 ggcagacgtg ggcctgcagg cccgccaggc gtgcggccgc gatgtgcagc cgccggatct
     7561 ggtcggggtg ggaggtggtc tccaccagcg cgaaggtgtc gtcgcgcagg cttttgatct
     7621 cggtgtacag gtcggccagg gggtgggaga cgtagtggcg ggcgaggcgg ccgatgtcgg
     7681 cttcgagcag gtccagggcg ggctcgtgca tggctttggc gaggacggcc cgggtctggc
     7741 gcagggttcg gtgcgcgtcc cgggcgagtg tgcggtcgag ttcgccctcc tctgagcggg
     7801 gtgcgccccg ctccgttcgg gtggggttcc tcggcgctgc agggggtcgg ggtatggggg
     7861 cgcccaggct ggtgaggacg gtgtggaccg tgctggcgcg ggtgagtccc tggccgctga
     7921 tggcgcgggt gatggtgctc tgggacacct ggcacatgtt ggccagtgcc tcgtgggtga
     7981 ggtcgggtgc gtggcggctg agcaggcgta ggacctgtcg ggcgtcgcgg gcgtcgacgg
     8041 cctgcaccat ctccggaagc cgccagaggt gttcggggat gcaggtgcac gggcggtgcc
     8101 gggtgcggcg ttcttttccg cagttcccgc agatcatggc ggcctttcgc aaaagagagc
     8161 tatttgccag ttttgtcgtt ttcgtgatct ttgaggggtg ccaggatcac ggtcgcgtcc
     8221 tcgctgttga agtgcggtga atcgaacaca tcggataccc gtgaaggcgc atatgcgtca
     8281 tcgcatggtg ccctcttccg tggtcgacga tacttcccac gacaccgtgt gaggacctgc
     8341 ggtgcgtcag acgtgagacg cccgctcctc cggcttttgt accggccgca ggaccgtacc
     8401 gacaacgacc cgggagccat tccatgaaag acgccgcgac cgtcgattcc gcccaggccg
     8461 cgcatctgcg cgaagaactc gtcgcccggc tcgtcgacga caaaacgatc gtctcccccg
     8521 gcgtcgagga ggcgatgctc gcggtacctc gggaacggtt cgcccccggg acaccactgg
     8581 aggaggtcta ccacccctac aacgcggtca tcaccaagac ggacggcagc ggtgtccagt
     8641 tgagttcggt gtcagcgccc cagatccagg cgatgatgct ggaacaggcc cggctccggc
     8701 cgggacaccg tgtcctggag atcggctcgg gcggctacaa cgcggccctc atcgcggaga
     8761 tcgtcggccc ctccggtgag gtcaccacgg tcgacatcga ccccgaggtc accgatcgga
     8821 cccggtccct gctgccggag aacggctacg accgggtccg ggtgatcacc gccgacgccg
     8881 agagcgggat tcccgaacac ggcccctacg accggatcat cgtcaccgtc ggaacgtggg
     8941 acatccctcc gggctgggtg gagaacctgg ccgaggaggg acgcctcgtc gttccactgc
     9001 gcatgcgcaa cctcacgcgc tcgatcggct tcgccaaggc cgaggaccgc ctggtcggcg
     9061 actccgccca cgtgtgcggt ttcgttccca tgcagggggc cggggagcac agggagaccc
     9121 tgctgctggt caacggaacc gaggagatcg ggctgcgttt cgacgacgag acgcctgccg
     9181 acccacaaag gctcgacaac gcggtgcgca caccgcgcgc cgagacgtgg accggggcga
     9241 cggccctgct gcaggaaccg atcggtgtcc tgcagttgta tctggccacc cacctgccgg
     9301 gcttttgcac catggctgtg gacccggaac tggacaccgg gctggtcgcc ccgagcaacc
     9361 gccgttcctc catggcagct gtcgcgggcg gcgacttcgc ctacctcgcc acccgccgca
     9421 caccggacga cacctcggtc gaatacgggg tgcacgcctt cggccccggc agcgaggcgt
     9481 tcgccgagac cgtggccgag cacgtgcgcg catggcaccg cgaccagcgc ggagggccgg
     9541 ggccgcgtat cgaagtcttc cctgcctcga cgcccgccga gcggctgacc ggcgaggcgg
     9601 tcatcaccaa gcggcactgc cgcatcacgt tctcctggcc tccggcgtcc gaccagggcc
     9661 ggggccaggt gttccctccg acctcaacac aaggagagtg acccgcatga tcggttccac
     9721 cgccggcggc tcggcggccc tggccgaacg gcccgccgtg tccgaggacg acttcgcgct
     9781 ggacgtgcgc gtggtcgtgg ccacccaccc cgtcggcaag ctgatgtgca acaccggcga
     9841 cggttgcggc aacacgtgcc aggggacggc gtcggcctgc aattcctacg tctccgaccc
     9901 ggtctgaccg acccagcgcg gcgggcggtc gacgccctct tcgccgactg cccgccgccc
     9961 tctccccctt ttgcccgtgc cgaggacgcg aggttgcacc atggccaaac gatccccccg
    10021 tgcctacgag tggtcgggcg gggcgctgct gcgtgccagt acgagccccg aagacctgga
    10081 cgtccccgag gacctggtgt cggaacactc acccgcgcgc gggctggagt ggctggcgcg
    10141 actgtgggag cgccgggagg tgcgcgatgc gctgtccgcg gccaacccgg ggctgtgctc
    10201 ccagatcacc ggcgccctgt ccggccgccg cctcgacgac cggagggtgc gcaagacact
    10261 gctgtcggtg gtgtcgtacc tggcgcgctg ggagcgtccg accccgttcg gcctgttcgc
    10321 gggaaccgcg ccggtctcca tcggtgcagc ggcccacacg gtctggggcg acggccaccg
    10381 ggtcgccctg cgggccgact ccgaatggct gtccgacatc atcgcccgtc tgcaccggtg
    10441 ccccgccctg gtggagcggc tgcacgtggc cgccaacaac accgggcagg tgcgcggagc
    10501 acggtacgtc gttcccggcc aatcggccga cggacactcc ctgcgcgcgg ccccggtcga
    10561 agtgtcggta cgccacagcc cacccgtggc actggcgctg gagatcgccc gcaccccggt
    10621 gcgctacgaa cgtgtgcgcg aacacctcac cctcggcttc ccccacgtgg ccggggagca
    10681 gatcaccgcg ctgctggagg gcctcatcga ccagcacctg ctgctgaccg acctgtgggc
    10741 gcccatgtcc tgcactgacg cgctcgccca tctgtgcgac acactcgccg ccgtacgggc
    10801 cgagaacatc gacgagatcg ccgacctggt ggccgacctc cacaccgtcc ggagccgcct
    10861 cgcccacccg gtgcggcaca cggcctggtc tgaacgggtt ccggtcctgg agcggatgcg
    10921 ggaactctcc gacgtggcac cggtccccgt catcgcggac accgtgctcg actgccgcct
    10981 cgctctgccc gaacgggtgg tgcgcaccgt ggaggaggcg gccgacgtcc tgacccgcct
    11041 cacccccgag ccgttcgggt cggcccagtg gcgcgactac cacgcgcgtt tccgcgcacg
    11101 ctacggcgcg ggagcggtgg tgcccgtgct ggaactggtg gccgacagcg ggctggggtg
    11161 gcccgccgga tacctggggg cctcccgtgg ccgccctccc cgcatgctgt ccgaacgcga
    11221 ccacaccgtc ctgcgtctgg tgcagcaggc ccaggccgcc gaagaggggg agatcgtcct
    11281 gaccgattcc acggtcaccg ccctggggcc cggttcggga gaggaggtcc ttcccccgcc
    11341 acgggtggag gtgtgcgtcc agatccacgc ccccacacca cgggcgatcg agaagggggc
    11401 gtacacggtg gccgtgaccg gggcgccgcg cccggcaagc agcatggccg gccgtttcgc
    11461 ccacctgctc ccggaggagg accacgaggc gctcgcccac ggtttccggt ctcccgaagc
    11521 cgggacggtc acggcgcagt tgacgttccc tccgcgcaaa cggcgcaacg agaacatcac
    11581 ccgcacctct cggctcctcc cgcacatcgt ccccttggcc gagcaccacc cgcccggccc
    11641 ggacgtgatc ggggtcgacg acatcgcggt gagcgccgac gcccaccggt tccacctgct
    11701 gcgcctgtcc accgggcagc gtctcgaact ccgtgtgccc cacgccctgg aggcgggcac
    11761 ccacaccccg ccgctggccc gcttcctggc cgaggtcgcc aacgcgcgcc acgcggtcta
    11821 cgggggcttc gacttcggcg ccgccgcgca gatgccgttc ctgccgcgcg tgcggtacgg
    11881 gaacatcgtg ctctccccgg cccggtggcg gctggacgca cgcgacctcc cccgattcga
    11941 tcagcaccgg cccgtgtggg acgaggggtt cgaccgctgg cgcgcgcggt ggcacgtccc
    12001 ggaccgggcg gcactggtcg aacacgaccg gcaccttccc ctggacctgt cccacccagt
    12061 gcaccgccac ctgctccgcc aacggctggc cgcccacggc caggtggaac tgcgcgagac
    12121 cgccacccgt gagcaggtgg catggctggg ccgctcccac gaactcctct tcccgctgcg
    12181 tgccagcggg tccggctctg tgcaccgcac cggtccggtg cgcccggtct gcgtcgacgc
    12241 ggcgcacctg cccggaagtt ccgtcaccag ggcccacctg tacgcccacc ccgaccgctt
    12301 cgacgagatc ctcaccggcc acctgcccgc gttgacctcg ctccttccgg attcggcgct
    12361 gtggtggttc cggcgacacc gcgacctgtc ccggccggac gccgaccggt acctggagct
    12421 gtacctgcgc ctcggtccag aacactccgg gggatccgcc gtcgagcagg tgcacgcctg
    12481 ggcacgggac ctgcggcacc agcgcctgct ggcgcacctg gaactggccg cctacgaacc
    12541 gcagaccggg cgtttcggcc acggggaggc gatggaggcg gccgaggccg tgttcgcggc
    12601 cgactctgcc gcggccctgg cccagatccg cgccgcccaa gggcaggggg tcgatccgct
    12661 ggccctgacc gcggccagca tcgtcgatct cgccaccggc ttcaccgaca cccccgagac
    12721 gggactggtg tggctgaccc aggacctggc ccataccccc ggcccggtcg accgcgccgt
    12781 ccgcagccga gccctggacc tggcctcccc tgccggggag tcgctgctgc ggctcgacgg
    12841 ggtggcggag gcctgggccg agcgggcctc agcactgtcc ggctaccgca aacgcctggc
    12901 cgccgagcgc gacccccaca gcgtcctgcg ttccctggtg cacctgcacc acgtgcgcgc
    12961 actggagatc ggtcccgaca gcgaagcggc cacgatccgc acagcgcggg cgatcgccct
    13021 gttccacacc gagtggaggt ccccatgaag gtgcccgtac cgagtccggc cgctcccgcg
    13081 gccgaggccg ccgaacgtat cgccgcgcgt ctggacgtgc cgcgccctgc gacggatccg
    13141 tggatggacc agtccctagc ccaaggcgcg gcgggaacgg ccctgctgca catcgaacgc
    13201 gcccacaccg gacggggcac gtggcagcac gcccaccggt gggtcaccgc cgtcgccgcc
    13261 acacagatca gtgccgccga caccaccggg ctgttcctgg gagcaccggc cgtcgcgttc
    13321 gtgctgcgcg cggcctccgg ttccgaccgc tacgccgagg ccctagccgc tctcgacgag
    13381 cacgtggccg aactggcgca ccgccgctcc cgggccgcga tggcgcgcat cggccggggc
    13441 gaactgtcca cgttcggtga atacgacgtg ttctacgggc tcaccggcat cggggcgtac
    13501 ctgctgcgca gcgccccgga gggaaacgct ctggagagtg tgctgcgcta cctggtcgcg
    13561 ctcacccgtc ccatgcccgg cgagtttgag gggcggccgg gctggtgggt ctcccacgac
    13621 ccgcaccggg gctcctcggc ccatttcgcg caggggcacg gcaatctcgg ggtcgcccac
    13681 ggcatcaccg gaccgctgct gctgctcagc caggcccaac ggcgcggcgt caccgtcgac
    13741 gggcaggccg aggccatcga gaccgtctgc ggccacctgg agcggtggtg ccagcccggg
    13801 gaacggggcc cctggtggcc cgagcacctg accgtccacg acctggggga aggcgttcca
    13861 cggcagccgg gtccggcgcg gccctcctgg tgctacggca cccccgggat cgcccgcgcc
    13921 ggacagctcg cggctgcggc cctcggcgat cgggaccggc aggcgttctt cgagaacgcc
    13981 ttggacctgt gcctgtccga cccggagcag atgagccgtg tcaccgacgc cggcctgtgc
    14041 cacgggtggg cgggggtgta ccagaccgtg tggcggaccg cccgcgacgc cgccaccccc
    14101 ggtctggacc gtcacctggc gggcttggcc gaccgtctgg tcgagcacgt cgaccggcgc
    14161 ccgggtacgg acgacttcct ggaaggggac gcgggggccg cgctggcgct gatgaccgcg
    14221 gagcgcggta cggatccgga atcggggtgg gactcgtgtc tgctgatcga ctgacagccc
    14281 cggcagggaa ggtgtcccgt agcggtgagg ccgttctggc ggtgctgcgg ggaacgcccg
    14341 tggcggaggc cgccgccgcg tccggtgccg acccggtcgc ggtggcggcc gacgtcgcgc
    14401 tgttctgccg ggccgggcac caggcgttgg aggcgcgcga tccgtggtgg cagctctacc
    14461 tggagttcgc cgactggcac cgggccgacg gggtcgcggc cgagcgcctg gtgccgaccc
    14521 tgcggttgct ggagtccgag gcgggcctgt cgtggtggta catccgcaag cacccctgtt
    14581 ggcggctccg gttgcgcacc cccgaccgag aggaacggat gagggtgcgg atcgagaccg
    14641 tgctgaacac tcttgtccgg gccgggcacc tgcgacggtg gtggacgggg gtctacgaac
    14701 cggagagcat cgtcttcggc ggacccgagg gcatggaggc cgcgcacgag ctcttccacg
    14761 ccgacagccg cgctgtgctc accgtgcagg aacaggacca tccagggctg ggacgccgtg
    14821 agctgtccgt gctgctgtgc tcggcactga tccgcggcgc ggggctggag tggtacgagc
    14881 agggcgaggt gtggcaccgc gtggcccagg agcggcccct gcccgaggac atcgccgagg
    14941 aacgcatccg ggccatggcc ggggatgtac acgcactcct gcaggccgat gtcagtagcg
    15001 gcggtcccct gttcgcagca ggcggagcgg ctgcggtggc cgcgtcgtgg gccgaagcct
    15061 tccacaccac cggccgcgtc ctcggcaagg ccgctcggga cggaagcctc caacggggac
    15121 tgcgccaggt actcgcctac cacgtgatct tccactggaa ccggctcggg ctcaggccgc
    15181 gagcacaaag cgccctggcc tgggccgcac gtaccgccgt cctggaccgg acacactgac
    15241 gcgcggcccg ctcccctggc actcctgcct ggaagaatcc gttgccggca ccatcgccct
    15301 cgcgctgacc ggccacagcg tgcgctggtg ccacggcgtc atggccgacc ccatcctgtt
    15361 gcacgcatgg atcgaggtgg acggggacgc cgtcgccgag ccggacagta cccgcaagtg
    15421 tgccgtactg ctggcactac ccgcgaagga gaacacgtga gcgatcccct gatctggcta
    15481 cgcggtgaga aagccggtat cggcccgctc cgcgcagacc tcgtcgagga gtactggcgg
    15541 tgggaacaga ccatccccac catcgtcggc tacaaccggc gcacccctca gcccatcgag
    15601 accacccgac tgatcctcat cgaaggctat gaccgggcct cggaccgaga gatccggttc
    15661 acggtctacg acctggcagg ctcagaaccc gtgcccgtcg gcatcgccca ggtgatgacc
    15721 gatcagccgc gcggcaacgg cgagtacatc gccgccatgg gggaatcccg gggcaagggc
    15781 gtaggcaccg aggcgacgaa gctcgtgctg gactacgcct tccacgtcgc gaacatggcg
    15841 tgcgtctggc tgaccgtgct cgaacccaac accggagcga tccgggctta cgagaaggcg
    15901 ggtttcaaac ggcagggcat tcggcgcaat tcgaacgtgt ggctcggcca gcgggtcaac
    15961 gaggtgctga tggacgcgct tcccgaggag ttcgaagggc cttctcgggt caaggagttg
    16021 ttccaaggct gatcccctcc gtctgagggg gccgctcagc ccggcaggag gtccatcgcc
    16081 cagccggggg ccagcaccag gaggaggaag cgggcggtgc gggtgaccat ggtgatcgcc
    16141 gagaacacca cgacgttcat ccgcaccgtc cccgccagca cgcagaccgc catgaagggc
    16201 ggcacgctgg cgaacgagct gagcgcgacc agcccggcgc cccacagcgg ccgcgcctcc
    16261 gccgaccggc gccagcgggc cacccgctcc gaccagcggc cggggtcgtt cttcctgcgg
    16321 tgcatccacc gcagggagag cgtgccccgg cccgcgtagt agtagggcag tttgcccagg
    16381 gtctggcccg cccccgccgc gaccgccatg gcggtgccga gcagggggcc gctgtccacg
    16441 gcgacggccg cgcccacgag gtagacctcg atgttgagca ccgggaccag cccggagagg
    16501 agggcgacgg cgaaggccag cgcggtctcg accatggtct cggcctccgt cgctcagccg
    16561 gtcagttctc cgccgccgcg agctggccgc acgcgccgtc gatctcctgg ccgcgggtgt
    16621 cgcggacggt gaccgagacg ccgtgcgact ccaggcgccg gacgaactcg cgttcgtcct
    16681 cgggccgcga cgccgtccac ttggaccccg gggtggggtt gagcgggatg aggttgacgt
    16741 ggaccaggtg gcccttgaga agcctaccga gcaggtcggc ccgccaggcc tggtcgttga
    16801 tgtccttgat gagcgcgtac tcgatggaga cgcggcgtcc ggtcgtgccg gcgtagcgcc
    16861 aggcggcgtc cagcacctcc tggaccttcc agcgcgtgtt gatcggcacc agctcgtcgc
    16921 gcagctcgtc gtcgggggcg tgcagggaga tcgccaggcg cacctgcatc cgctcggcga
    16981 tgagcttgtc gatggcgggg accaggccga ccgtggacac ggtcacaccg cgttgggaga
    17041 tgcccaggcc gcggggtacg gggtcggtga tgtggcgcac tgtctggagc acccgcttgt
    17101 agttggccat gggttcgccc atgcccatga acacgatgtt gctgatccgc ccgggccctc
    17161 cggcgacctc tccgcgcgcc aggtcgcggg cgctggccac gacctggtcg acgatctcgc
    17221 cggtggagag gttgcgggtc agcccggcct ggccggtggc gcagaagggg cagttcatgc
    17281 cgcacccggc ctgggaggag atgcacaggg tgacgcgatc gggatagcgc atgagcaccg
    17341 actcgaacag caccccgtcg aaggccttcc acagggtctt gcgggtcatc ccgttgtcgc
    17401 aggtgatgtg gcggacgggt gtgagcaggg tcggcagcag ggcctcgccc aggcgctccc
    17461 tggaggactc gggcaggtcg gtcatcgccg aggtgtccga ctccaggtgg ccgaagtagt
    17521 gctgggccaa ctgcttggcg cggaagggct tctcccccag ccccgtgacg acctcggccc
    17581 gttcgtccgg ggtgaggtcg gcgaggtgcc gcggcggctg ggcgcggcgg ggggcgacga
    17641 aggtgagctc ggcgggcata ggtatccgta agagacggtg tcggtggtct gggcccggcg
    17701 gcgcggccgg gtcgttatac gacctatacg cggctgcggt gcggctccgc ctgcgagggc
    17761 actacggtcg attctacgca ctgtccggca cgggccgggc gggttcgccc gcgacgcgga
    17821 cgacaacacg gatcggcacg tgggagggcc ggtgtcaggg atcaacgtcc ttctcgacga
    17881 gatcagcccc tatcagagcc gccgtgtcgt cgtcgagtgc gattcccgca ccacggccgc
    17941 ctacctcctg gacgcgcgcg ggcgcatccg ggtgccggtc tggctggcca accacgagcc
    18001 cgcccccgcc tcagacgagg agggcgggtc gttcgagggc cgggcaccgc tgatgccgga
    18061 ggcctacacc aagcacccgc agggcctgcc ccgcttcgac ccctcggcgc tgcgcgccgt
    18121 ctggttcgag gagggcgacg gcgtggccct ggtagacgag caagggctgc tggcggtcat
    18181 cccggggtgg gcggaggccg acagcggact gcccggctac gcgcgcgagg cggtcgggcg
    18241 cagcgcctac gcctgggaac tggactcggt ccgggggcac ctgtggccgc gtgtggtgca
    18301 cgccgaggcg tactgggact ggcgccgggc cgcgggagcc tggcgcggtg tccagcgcac
    18361 ggtgctgggc cacctgaacc gccgtgtggg cgagcccggc cactactggg acgtctccga
    18421 cgggcacccg cccctgctgc ggctgtcgga acggccgccg actgcggagc ggccgttcac
    18481 ggtgctgtcc acggtgggga tgtgcgggca gcggatgccc acgctggacc ggtacatggc
    18541 cgacacctcg cggcatgcgc gggtggagct ggccctggcc accacgatgc ccgcgcaccg
    18601 ggcggcgcgg atcttccggt ggatcggtgc gtttccctgg cgcgcggtga cctggttcgg
    18661 gaccggccac accgtgaagt ggctggacaa ccccgaggac cgggcgatgc gcggcgaggc
    18721 gggcgcggtg ctcctgttgg aggatcccgt gccgctggcc gccgcgggga ccgggcaggc
    18781 cccgcccgac ctgtcgggcc tgaccttcca gggcgacccg gtgcggtggc tgtggatcgt
    18841 accgatcacc cgcccggagc acctgttcgc caaggagcac gacagcgcgg ccctggtgga
    18901 gaagctctcc gcggagggtc ggggctgggt cctgggctag ctggcgatgc cccgccggtc
    18961 gcgggcctgg gcaagcagat ggtggaaacg ggccatgtcc tcgtcgctga agcgctcaac
    19021 gaagctgacc agggtggccc cggggtcggg gccggcgttg aggacctcgt ccatgacccg
    19081 ggcggtgtac tcggcgtgcg tctcacgcgg ccagtagacc caggcgcgcc cggacttctc
    19141 gcggtcgagc aggcccttgt ggaagaggat gttggcgacc gtcatgacgg tggtgtaggc
    19201 gacctcgcgg tcgtagacca tgctctcgcg gacgcggcgc accgacagag gctcctcgga
    19261 ccgccacagc gcgtccatga tggccgcttc gagttctccg agccccctca ccgcgcccgc
    19321 ctccctgccg tacggcttct cacgtccccg atttccgtac ggagatcgta gagggactgg
    19381 aggtgttcgt ggggcggaac gccggaaagc acgcggatac gcacaccagg aagcggaaga
    19441 ccggcgtttc acggtcgcgc accgccgtct ccggctggaa aaggggcact cggagccccg
    19501 gttccgatcc ccgtcaccgg accctgtcca gagggggcgc gggtgtgaca caccacattc
    19561 ccgacggttg gcagtggctt gcccgttcac actccaaaaa caccacaaaa atgtacattt
    19621 acgacaattc aaggaccctg agtacagact ccgctacgaa gaggcaatga acatgtgaaa
    19681 gattgttacc tacctcctgg tttcaacacc actcaaggtc gccgccggga agcgggtaca
    19741 agtagcctgg tacgaggacg agtgctggcc ggacccaggt cctcccgcta cggcggggaa
    19801 cgttccatgt cttcattgag ccgggtccac cagcagccac ccgtccgtac acattcacta
    19861 gcgagctgcg gaagtgggcg atctccgccg tgtcgtctga ggcgtctcaa cccctgacag
    19921 atttcggccc caacgagtgg ttggtcgagg agctttatca gaagtacctg accgaccccg
    19981 actccgttga caaggcctgg tggaacttct tcgcggacta caagcccgcg gataccggtg
    20041 cgcagggcgg aggggcagcc aaggccgcga aggcgaagaa gagcaaggcc cccgcggctc
    20101 cggcaccgaa gaagaccgcc aagaccaccg aacccgagag cgacgaagtc aagcgggagc
    20161 ggctgcgcgg tgctcccgct cggaccgcga ccaacatgga gtcgagcctg gcactgccga
    20221 ccgccaccag tgtgcgcgcg gtcccggtca agctcctgtt cgacaaccgc atcgtcatca
    20281 acaaccatct ccggcgcgca cgcggcggga aggtctcctt cacgcacctc atcggcttcg
    20341 ccatggtcag ggcgctggag tcgatgccgg agatgaacca ctcctacgtc gaggtcgacg
    20401 gcaagcccgg tgtggccaag cccgaccacg tcaacttcgg cctggccatc gacctccaga
    20461 agtccgacgg ctcccgccag ctcgtcgtcc cctccatcaa gggcgccgac gagatggact
    20521 tcgcggagtt ctggagcggc tacgaggacc tggtccgcaa ggcccgcaac aacaagctgg
    20581 gcgtgcccga cttccagggc accaccatca gcctcaccaa cccgggcggc atcggcaccg
    20641 tgcactcggt gccgcgcctg atgcccgggc agggcaccat cctcggcgtg ggcgcgatgg
    20701 agtaccccgc cgagttccag ggcgcctccc aggacaccct gagcgagctg ggcatcagca
    20761 aggtcatgac gctgacgtcc acctacgacc accggatcat ccagggcgcg cagtccggcg
    20821 agttcctgcg ccggatccac cagctcctgc tgggcgagga gggtttctac gacgagatct
    20881 tccgctccct gcacatcccc tacgagccgg tccgctgggt gcaggacatc cacgtcaaca
    20941 cggccaccca gctcgacaag gccacccggg tccaggagct gatccacgcc taccgcgtgc
    21001 gcggccacct catggccgac accaacccgc tcgaccacga gcagcggcgc caccccgacc
    21061 tggacgtcct ccagcacggg ctcaccctgt gggacctgga ccgctccttc cccaccgggg
    21121 gcttcggcgg caagcaggtc atgaagctcc gcgacatgct gggcgtgctg cgcgacacct
    21181 actgccgcac ggtgggtatc gagtacatgc acatccagag cccggaggag cgggagtgga
    21241 tccagtcgca cgtcgagcgc gagcacgaga agctcgaccg cgacgagcaa ctgcacatcc
    21301 tgcaccggct caacagcgcc gaggcgttcg agaccttcct ccagaccaag tacgtgggcc
    21361 agaagcgctt ctccctcgaa ggtggggagt cgctgatccc cctgctggac ggggtgatcg
    21421 cccgtgcggc ccgcgccgag ctggacgagg ccgtcatcgg catggcccac cgcggccgcc
    21481 tcaacgtgct cgccaacatc tgcggcaagt cctacgggca gatcttcggc gagttcgagg
    21541 gcaacctcga cccgcgcagc gcgcacggct ccggcgacgt gaagtaccac ctgggcaccg
    21601 agggcgtctt cgagaccaag gacggcgagc gcatcgccat ctccctggcc gccaacccct
    21661 cccacctgga gacggtcgac ccggtcgccg agggcatcgt ccgcgccaag caggacctgc
    21721 tgaacaaggg tccgcacggc ttcacggtgc tgcccatcct catccacggc gacgcggcgt
    21781 tcgccggaca gggcgtggtc gccgagaccc tgaacctgtc gcagttgcgc ggctaccgca
    21841 ccggcggcac ggtgcacgtc atcgtgaaca accaggtggg cttcaccacc tcgccgtccg
    21901 acagccgctc cagcgtgtac gccacggacg tggcgcgcat ggtgcaggca ccgatcttcc
    21961 acgtcaacgg ggacgacccc gaggccgtgg tccgggtcgc gcacctggcc ttcgcctacc
    22021 ggcaggcgtt caacaaggac gtcgtcatcg acctggtctg ctaccggcgc cgcggccaca
    22081 acgagggtga caaccccgcg ttcacgcagc cgctgatgta cgacgtcatc gactccaagc
    22141 gctccacccg caagctgtac accgaggccc tgatcggccg cggcgacatc acggtggagg
    22201 aggccgagtc ggcactgcgc gacttccaga gcgaactgga gcgcgccttc agcgagaccc
    22261 gcgaggtcga gaagcggccg gtcgaacccg gtgccgtggt caagcccgag gtgttcaccg
    22321 agggccgctt ggaccactcc gcggtcgaga ccgcgatcag cgccgagacg gtgaagcggg
    22381 tcatcgacac gcaggtcaac ctgcccgagg acttcaccgc gcaccccagg ctggcaccgc
    22441 agctccagcg gcgcgcccag gccgtggaga gcgacacggt cgactgggcg accggtgagc
    22501 tgctggcctt cgggtcgctg ctgctggacg accacccggt ccgcctggtc ggccaggaca
    22561 gccggcgcgg cactttcggg cagcgccacg ccacgctgat ggaccgcgag accggcgcgt
    22621 cgtacacgcc gctcaagcgg ttcgactcgg gcaccacccg gttccacgtg cacgactccc
    22681 tgctgagcga gtacgcggcc ctgggcttcg agtacgggta ctcgctgacc cgacccgagg
    22741 cgctggtcat gtgggaggcc cagttcggcg acttcgtcaa cggcgcccag agcgtcatcg
    22801 acgagtacat cagcgcgggc gagcagaagt ggggccagcg ctccagcgtg accatgctgc
    22861 tgccgcacgg ctacgagggc caggggccgg accactcctc ggcccgtatc gagcggttcc
    22921 ttcaactgtg cgcgcaggag aacatgaccg tggcgatgcc gaccaccccg gcgagctact
    22981 tccacctgct gcgctggcag gcgaagtcgc cgctagagcg ccccctggtg gtgttcacac
    23041 ccaagtcgct gctgcggctg aaggccgcgg tctcggcggc cgaggacttc accacgggcc
    23101 acttccgtcc gctgatcacc gacgattcca tcgctccgga gaaggtccgc cgggtggtgc
    23161 tgtgctcggg caagatctac tacgacctgg acgcggcacg ccgcaagagc ggggacaagc
    23221 acaccgcgat catccgcacg gagcggctct acccgctgcc gatcgaggag atccgcgagc
    23281 agctcaaggc ctacccgaag gcgggcgagg tcctgtgggt ccaggaggag cccgcgaaca
    23341 tgggcccgtg gccgttcgtg gcgctggtct tctccgagca gctcgaccgt ccgttcaccc
    23401 ggatctcgcg tccggcgtcc tcggcaccgg ccgccggttc ggccaagcgg cacgaggcgg
    23461 agcagcgcgc cctcgtggac acggtgttcc cgcccgcgga ctagcggtgg tggggccggt
    23521 gctccgtcgc ggggcaccgg ccgacccgtg aggccgcaga aggcgcgagg ggcgcaccgg
    23581 tctctgcagg aggagccacc gccgaagcga ggaacgagca agaaggtagc gacgacgaag
    23641 aggccggttc tccgcgc
//
