LOCUS       NZ_AZXF01000017        25431 bp    DNA     linear   CON 21-OCT-2024
DEFINITION  Nocardiopsis sp. CNT312 B042DRAFT_scaffold_11.12_C, whole genome
            shotgun sequence.
ACCESSION   NZ_AZXF01000017
VERSION     NZ_AZXF01000017.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Nocardiopsis sp. CNT312
  ORGANISM  Nocardiopsis sp. CNT312
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 160291)
  AUTHORS   Jensen,P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R41043
            investigation_type                :: bacteria_archaea
            project_name                      :: Nocardiopsis sp. CNT312
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi14643
            Funding Program                   :: DOE-CSP-ICBG 2011
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000515115.1-RS_2024_10_21
            Annotation Date                   :: 10/21/2024 21:26:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,296
            CDSs (total)                      :: 4,234
            Genes (coding)                    :: 4,144
            CDSs (with protein)               :: 4,144
            Genes (RNA)                       :: 62
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 23 of 90
            Pseudo Genes (incomplete)         :: 74 of 90
            Pseudo Genes (internal stop)      :: 5 of 90
            Pseudo Genes (multiple problems)  :: 12 of 90
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:21:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 114863
            Orig. end                         :: 140294
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AZXF01000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..25431
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25431
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25431
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15431](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15431
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            1536..2396
                     /locus_tag="B042_RS0108425"
     CDS             1536..2396
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151068.1"
                     /locus_tag="B042_RS0108425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3566 domain-containing protein"
                     /protein_id="WP_028647924.1"
                     /transl_table=11
                     /translation="MSDKQRNTSTNESDTDTPTTAKDEAVADRAPVDGADTVAVATKSS
                     FPGRDEDGPGQGPETRDDAVEAPAVTTSSGGSDTGGATSAEKPSEESEGGEPEAGSPGR
                     GAASEATGSSATKKKEEAVDTRSDQSTGDTEGPGGTEVTESKTAAAKQPSAVKATLSSR
                     RAHLTVSRVEPWSVMKYSFVVSLVCFIVLFVAVVVIYTTLSMLGVFDELSNMMTALLEG
                     DGSEDELGLNPSAWFSPGRVLGYTGVVGALNIVLITALATVGAMLYNLVADLVGGIDLT
                     LTEAE"
     gene            complement(2496..4283)
                     /locus_tag="B042_RS0108430"
     CDS             complement(2496..4283)
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017584811.1"
                     /locus_tag="B042_RS0108430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiamine pyrophosphate-requiring protein"
                     /protein_id="WP_028647925.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.8e-43, bitscore:
                     141.4, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-28, bitscore:
                     93.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADMVSDYVLKRLREWEVEHVFSYAGDGINSLLGAWGRAEDRPRF
                     IQSRHEELAAFEATGYAKFSGRVGVCAATSGPGAVHLLNGLYDAKLDHVPVVAIIGQTA
                     RSAMGGSYQQEIDLLSLYKDVASDYLQMVTVPEQLPNVLDRAIRTAVSRRTVTALIIPA
                     DVQDLEYSPPRHEFKMVPSSLGLSDTETVPSAEGLARAAEVLNSGERVAILAGQGARGA
                     PGELTEVADVLGAGVAKALLGKDVLPDDLPFVTGSIGLLGTRPSYEMMRDCDTLLVVGS
                     NLPYSQFLPAFDQARAVQIDIDPTMLGMRYPFECNLVGDAARTLQALLPLLERKTDGSW
                     REKIEDDVERWWEVLGRRAMVDAEPINPQRVFHELSPLLPDDVIVTSDSGSAANWYARY
                     LRFRTGMRGSLSGTLATMCPGTPYATGAKFAHPNRPVIALVGDGAMQMSGINELITLAH
                     YWHEWEDPRVVIGVLNNGDLNQVTWELRAMGGTPRFTPSQRIPDLPYAQIARDMGLAGA
                     RIEDPSEVADAWRRALNADRPCVVEFVTDPAIPPIPPHATLDQMESMTAALLKGDPEAW
                     AVVKEGVKSKAQEFIPGPR"
     tRNA            5232..5305
                     /anticodon=(pos:120129..120131,aa:Ile,seq:gat)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="B042_RS0108435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Ile"
     gene            5232..5305
                     /locus_tag="B042_RS0108435"
     misc_feature    5865..5879
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 22.6"
                     /tool="antismash"
     gene            complement(6077..6328)
                     /locus_tag="B042_RS22395"
     CDS             complement(6077..6328)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570239.1"
                     /locus_tag="B042_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA-binding protein"
                     /protein_id="WP_197024208.1"
                     /transl_table=11
                     /translation="MAEDRRAFTIHELYELPAAVDLMTAARALHMGRTTAYELARRGEF
                     PCRLLRYGTTYRVVTVDLLKLLGVPLPERREPTATETA"
     misc_feature    complement(6388..6400)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 21.19"
                     /tool="antismash"
     misc_feature    6499..6512
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 21.45"
                     /tool="antismash"
     misc_feature    6658..6678
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            6666..7298
                     /locus_tag="B042_RS0108445"
     CDS             6666..7298
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012905.5"
                     /locus_tag="B042_RS0108445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAD family phosphatase"
                     /protein_id="WP_028647926.1"
                     /sec_met_domain="HAD_2 (E-value: 2.5e-14, bitscore: 47.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTTESKYSGVIFDFFGVLTFNMVEVISSFEDREKLPRGTFLRA
                     WADQRGQELFQQLELGQITQAEWNKGFAALIGVAPDDLMARYLHDAFPAYQMLKVARQA
                     RQAGIKTAVLSNSLGREPYDPYAGFDLHGTFDEVVFSTDHGIRKPDPEIFRLVLDKLGV
                     AAQRCVFVDDSEDNLAAAHWLGLTPLLALDEDVAAPRLRHMLDLPHP"
     gene            complement(<7433..7905)
                     /locus_tag="B042_RS26455"
                     /pseudo=""
     CDS             complement(<7433..7905)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291692.1"
                     /locus_tag="B042_RS26455"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFDVTGHSDLRLTGSPRCVRPWTRLWLPTLTARSPVSPVWHAERT
                     SSSPKPCSRSADCSKSSCPPSTTWRPRSSPTTWTGSTAC"
     gene            8087..8230
                     /locus_tag="B042_RS0108455"
     CDS             8087..8230
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B042_RS0108455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_231493873.1"
                     /transl_table=11
                     /translation="MFSTGTGTVIVQGPLLKATEELTLSTGEVAVEIPAHLIEEAARAL
                     GR"
     gene            8214..8738
                     /locus_tag="B042_RS0108460"
     CDS             8214..8738
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017564552.1"
                     /locus_tag="B042_RS0108460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6879 family protein"
                     /protein_id="WP_028647929.1"
                     /transl_table=11
                     /translation="MRLEGDAWQEFFHSFRREAFRLETLPSYTVPEEEDELRRFLAGEA
                     RPAEELHTDTYLIKVREHVEAGRRMRRVHTLTSPVGDHLRFQFEWGYAFSVQAGEEVNI
                     LDFATTPDPGLPRQDFWLFDDTHVVLMHYAADGTQTGRELLEDTDPAPYVRYKDLALEH
                     STPFTEYYKVR"
     gene            8739..9611
                     /locus_tag="B042_RS0108465"
     CDS             8739..9611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610920.1"
                     /locus_tag="B042_RS0108465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_028647930.1"
                     /transl_table=11
                     /translation="MTLEPENADRQRGELADALRRLRRSAGMTGAGLAARAGMSQAKIS
                     KIENNRIRPSHLDVERILTALGVPLEGQDGVRLLELARVTNSDYQGFRTALQRGLGELQ
                     RDLAAIEGAATTIRYFLPCMITGLLQTPEYARQSLAHPLVNRGAEWHTALARRLERQQA
                     LYQPGRRFVFVLTEAALRWPLCPPAVMALQMDRLASLSELAGVDIRIVPAHPPVPSGPL
                     NGFTLYDDRLVTVEVFTGELALRDPKDIAYSEEIFDFYHGRSLAHDDARSFLGRFAQEY
                     RERAKTDIP"
     gene            9706..9879
                     /locus_tag="B042_RS24865"
     CDS             9706..9879
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573280.1"
                     /locus_tag="B042_RS24865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_081748662.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 5.4e-15, bitscore:
                     48.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLAQESQQDTQTHAPSSPFVLDIRLIETSDTTPLINLTDDGCGT
                     TCPSTCVTSVSD"
     gene            10001..10345
                     /locus_tag="B042_RS27025"
     CDS             10001..10345
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="B042_RS27025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_369797688.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.1e-12, bitscore:
                     37.2, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRWQVRGTPVIRAPITDGSPVSWWPNLPGNDVDEWVHWLGCVW
                     AASELAEAIRHASPDLAAGVDDLRSRAPDGIRVRRARKVTAAVVRYVLRARHRANPVRP
                     LCGHRPGGLR"
     gene            10263..12161
                     /locus_tag="B042_RS0108475"
     CDS             10263..12161
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="B042_RS0108475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_197024210.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.8e-149,
                     bitscore: 491.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-20,
                     bitscore: 67.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCATCCGPGTGPTPFGLFAGIAPAAFADAASVAWGHDHHAVASPS
                     GEWITEITDHLVDLPQVRQRLFLAANHTAWRTQDHLVVPQHARPAPPHPRAATAEVEIR
                     LTGAVRLVLDAAQRPVPWATLAAKLTAEYPDEPAQSAENLLTQLIRARALLTSLSPTSV
                     ETDPLAYLARALDGMVEVSPPVPLLDGTRSVVRIRHRHGSGPAVRAESMKAARHLCDTG
                     RTGIDVRLDATVSLPAEVVYTAEKAAHMLTVLSAYPEGIPAWRGYRDRFAYRYGTDPVP
                     VAEAVHPSTGLGFPHSYTSTGSEAPAAALSVRDRWLMGQAQDAALTGRREVRIEELLAA
                     QETVYSSAPPENTELNLRLESPSRAALDSGRFRLVVLGASRSAGTMAGRFAALTGIETD
                     LAEVLTGSGPLPVQMSFPPQRSGSVPVTRAPRLLKHVLHVAEYPSTGTDALTVDDLFIG
                     DDGTELFLWSRSLQRAVVPVVPHALNLRHAPPLARFLAELPRAGKTVVSGFDWGAASFL
                     PFLPRLRSGRVVVANARWRVTAADLPPITAAWPRWQSAWQAWARSRNLPALVELGEGDQ
                     RLRLDLTQPGHLFLLRSHLNKEGATVLTEAPAPDSAGWCDGRPVEILLQLQRKGTV"
     aSDomain        10467..10745
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B042_RS0108475_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="2.20E-21"
                     /identifier="RREFam001.1"
                     /label="B042_RS0108475"
                     /locus_tag="B042_RS0108475"
                     /protein_end="161"
                     /protein_start="68"
                     /score="67.4"
                     /tool="antismash"
                     /translation="AANHTAWRTQDHLVVPQHARPAPPHPRAATAEVEIRLTGAVRLVL
                     DAAQRPVPWATLAAKLTAEYPDEPAQSAENLLTQLIRARALLTSLSPT"
     gene            12158..13417
                     /locus_tag="B042_RS0108480"
     CDS             12158..13417
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573277.1"
                     /locus_tag="B042_RS0108480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_028647932.1"
                     /sec_met_domain="LANC_like (E-value: 4e-42, bitscore:
                     137.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPLIDASAVATRAADHLATPDQGRALAQNRWWPQSLAHGAVGV
                     ALLHIERARTGHGPWERAQTWLECAVSDGVDASPEAHLYYGAPALAFVLHQAATVHLGY
                     ERELEQLDAAVARIVAARLEQAHARMDTRGRLPVLAEFDAIRGLAGLSALLLTRDSYQD
                     LLRRALVYLVRLTEPVTAPDGQQTPGWWASVDPAGKESPDLFPGGHANTGVAHGICGPL
                     TVLASALRHGIEVDGHTRAISRILDWLDLWQRTDPDGVWWPYWITAAQHRGEEEPVGPQ
                     RPSWCYGAAGVAHAQLLAADALGDTNRSMNAQATLARTLTPQSAVGTTLDTSLCHGYSG
                     LALLAHATGTARVPALLAPTAEGHDPDDAVRRLLTRNGIGLLEGAAGTATALHTLTTDP
                     NPLGWASFLLIGYAKERVHA"
     gene            13410..15431
                     /gene="fxlM"
                     /locus_tag="B042_RS0108485"
     CDS             13410..15431
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573276.1"
                     /locus_tag="B042_RS0108485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_028647933.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-29, bitscore:
                     97.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.7e-50, bitscore: 164.3,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDEHPQTLIEWPDWATAEHTAAQHLGPILGLGRRRGLLTGWWFI
                     RKKPYWRLRYTGGHRARRFLDAHLERLHRAESVSAWAHAIYEPETGAFGGQAAMSLAHT
                     LFHADSRHLLTYLAHVHTNPSTELGRRELALLMGGAFLRGARLDAFEQADVWEKVTALR
                     RLPQPFTADERLLAPARTLTALDPRAVAATSPHTTAWAQEFTAAGAVLSRLAAEGRLTR
                     GLRAVCAHHLVFTFNRWGLTYQDQHVLSNLGKAVMTDTADNAPASPETAETLREDLIRK
                     LRENGSITTSEVEDAFRRVPRHTFVPHATLEEAYTNAPVHIKHDDDGASISCASQPGVV
                     ALMLEQAALAPGMRVLELGSGTGYNAALLGHLVGEGAVTTIDVDQDLVDGARTRLKDHG
                     ATNVTVHLGDGALGHPGGAPYDRVIATVGSHDVPRAWVDQLAPDGRLIAPVRIAGDVNR
                     SIVFERDGDRWRSVDSQLCTFMPLRGGGIGDDPRRVLSLDRDGTVQIQANQDQTITEAQ
                     VHDVLGEEATTVWTGVTYGKSQPLDTMWLWLATHLDNRLSRMPLRRHAVANGLVSPGLP
                     WGDMAAVPAAERGLAYLTLRPVEGHRGRHELGVVGHAAAGRKLAEQMGAQAAAWEPHRD
                     DDISFALHFTPVTEAPSDTRRVLKRKHSILVVSWGEPA"
     gene            15428..16516
                     /locus_tag="B042_RS22400"
     CDS             15428..16516
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573275.1"
                     /locus_tag="B042_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_036554306.1"
                     /transl_table=11
                     /translation="MSAGQWFPLVPWPRPPGEKLATRIERITTAAQTVRCGEPSDAVAA
                     AAQVYNGAALIASDVGLPELARDWCWEHARLYLAHLPLDARMAQRALEPVVNLARLQIR
                     AGEGGAAFGMLTALREGVRTAASIVIDGHELPLDRLIASEEDRAELYRWVWTVCLGDGT
                     RALASQGQWSRAAEHAQQHMGVGERLFDGRQAAVIAELVGGAPEAALALVEGSAVQEPW
                     ERAVQRVLALWCRVEAGGVEDGEAATVLQRVRVAQEGRVVFRTRLGIAAIEVAGGLSEE
                     AGPLVAPVVSAVIQERDGYAVRDVLRAWEDRLPQDSRAALRTVLDESGLDSGVLQEMPL
                     QALTESLQEAHGRLSGADLLLM"
     gene            complement(16710..16904)
                     /locus_tag="B042_RS0108495"
     CDS             complement(16710..16904)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.5"
                     /locus_tag="B042_RS0108495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_028647934.1"
                     /transl_table=11
                     /translation="MIDRTGGWHTSTYSGARGECVEVNETNPLEGVLMRDTQNRAHGHL
                     GFEAGEWITFLDAMRDTHR"
     gene            complement(16901..17710)
                     /locus_tag="B042_RS0108500"
     CDS             complement(16901..17710)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="B042_RS0108500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_197024212.1"
                     /transl_table=11
                     /translation="MPEKVLTAWVTFGRELRRQREGRGLTLDQAARETGYGASTISKYE
                     NAYRSPKRDFVHETEALYRTNGDLLRRWEEAQRAADDPDWHRKVVTAEEQASGIKFWNP
                     GLVPGMLQTSDYARQVFRDGAPLDTDHEIERLVELRVNRLDTLRKMNNPRMLAILSESV
                     IRARVGTGVVMAEQLHHLLELSDSGIVRVLVLPMEAPYYGGASGPFRLIEFRDRPTLVE
                     VEHASGSELLGGDPVARLGAVYGELQTWALPPVASREKIVEAIGGLE"
     misc_feature    complement(16907..16909)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17976..18425
                     /locus_tag="B042_RS0108505"
     CDS             17976..18425
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608547.1"
                     /locus_tag="B042_RS0108505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_028647936.1"
                     /transl_table=11
                     /translation="MHQSIAPPSALPRRLRGTPTRSGLLLGPDLGHVAIARRWAARATR
                     TRLGLAEPLALAVSELTTNALRHTASGLPGGTVRVEIDRTGHLELRVTDDGPRLGTATT
                     PPAIPALDPFRVGGNGLRLVEAVCAYWDWTRNPDGGTTVRAVFPR"
     gene            18554..19240
                     /locus_tag="B042_RS0108510"
     CDS             18554..19240
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.5"
                     /locus_tag="B042_RS0108510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_155988958.1"
                     /transl_table=11
                     /translation="MTVLLCRHCGSPRHSGAPAYRCTCIPAHVWQSTEAARAVRALNLS
                     KVIQYLRRHPDTRHLSQAALADMCALSRAMISRLENGTTATRIDRAVTALAGLGAPQVP
                     GEIHQPHLDEDPPPPAGPRDDYGVPCVVLTSPAPIRVHVRDPDPDQDTPDPDGGVPGSV
                     VFVAHPDDPCLVVDHGTAWGVTNTGHGATAWFALPTHWPQTPHPPDAAPEQEQPAEPPE
                     PPREQS"
     gene            19385..19639
                     /locus_tag="B042_RS0108515"
     CDS             19385..19639
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B042_RS0108515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_028647938.1"
                     /transl_table=11
                     /translation="MTAAQAELERRHRAPARCPRSCTEYLNTRYGIRAPRPGPLFRDDP
                     VKTAEAVLRGHGIPLRGPPDDEFRELSALVRLYLARRSG"
     gene            complement(19741..20283)
                     /locus_tag="B042_RS0108520"
     CDS             complement(19741..20283)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.5"
                     /locus_tag="B042_RS0108520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_231493874.1"
                     /transl_table=11
                     /translation="MLAPGVLVVVVLLAIGWYSDQTPAGILWGLLAALFCGIVPYAILI
                     LGARIGWWTDRHVRERRQRFVPLLIVIGCVTLGIATLVLLDAPRELFALVVAMLTALAI
                     TLAITVKWKVSVHTAVAGGVSTVLVLTYGAVMAATVPLIALVGWSRVRLGDHTPAQTVV
                     GAVFGAAVAATVFSLLR"
     misc_feature    20758..20773
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            21388..22305
                     /locus_tag="B042_RS0108530"
     CDS             21388..22305
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608914.1"
                     /locus_tag="B042_RS0108530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="replication-relaxation family protein"
                     /protein_id="WP_028647940.1"
                     /transl_table=11
                     /translation="MPIRTTEASELAQHALAVLYQHRLVTSHQLARLLTPEANSRRYML
                     HILHRLRQQGLADRVVPPGRRPHRWFLTLAGARAVQEAGQLSARPYRMSPERAAGPLAE
                     HMLAVVETGLAFFAHAHRLDDEFGLLHWVPEVAHRYTKGSGRFADTHVISDALMHYITV
                     RPDGRRVQYQFLVEVDRTTMPVTRLVAKLVAYARYFDHHPLRRRTSVTGRSARPAWQDR
                     YPFFPRVLLVLDGANERRLRNRGVDLAAYARLLPYLTVERPGFRVGYTTMPDLVEHGPR
                     ERIWTNLLSPGRDGEQYTDFTLRA"
     gene            complement(22424..24922)
                     /locus_tag="B042_RS0108535"
     CDS             complement(22424..24922)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.5"
                     /locus_tag="B042_RS0108535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_028647941.1"
                     /transl_table=11
                     /translation="MRKPLSLRLAWRMVRKDGRRALAGAGLLGLPVAVAVFAQILYSTA
                     VPTAEEEQVAAMGAAQARVYTASGKASAAELEDALPEGVRIVPAAGSVIAADTGHGPVP
                     TSVVLADLSDPLTDGLLEVAEGRTPEQTGEVLVSRHLGHGSQVEIGDRVTVGSEHTVTV
                     TGLVVDPTDHDRDFLVGLPQDPVLSASAEDNGPWLLGGLPSGTGEPELTQLLGPLGFTV
                     DPRTSGPTPGAPPAAEDTTRDDDRAVLLFTALGLGEVALLAAAVFTLSAQRRRRDMGLL
                     AAAGARPGLLRRTVLLHGVLVAATGALAGTVVGVVAALLAQPLGERITGLSWGAPVIRM
                     DQLVWIGALSLVGGLVAAWLPARASARWGPVDMLRDVPGGTVPRRRRWIWPTAAVAGLA
                     ALIGGTVIGAIPLAGAGGVVYALGLLGSCGLLLSLSSVVAARLPVRTRVALRTPARTMS
                     RSLPLAVAICAVTASASVAGVLVRSADEYNAATYVPGLLHGQAMVSGPLPADDSVLSPL
                     TRELGGAKVVRIPYAALPTDGEPTRVVLDNDTWRCALAGDGTEGCSPDLPPGLTPVQAV
                     AVADEALVSARFRGDGQREQALRALRDGRVVVTDDALQHNGRVLLRPGADPSGPAVEMD
                     AETVPTDDHGTRLPNALISAQHLDEHGLAAVTARDALLVAGTDPTADQIEAAQAATDRH
                     LGGQAELYIERGYDGTEISALLWLITGLATVTAAGTAAIAGALSAEENARDDAVMAAVG
                     APPRFIRRMVAARLLALAVPASVLGALGGSAAMTAAVWAWGTWPPAIPWLPLLATVAAI
                     AVATWFTGYRTKAARPALEN"
     misc_feature    24969..24983
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
ORIGIN
        1 atcctccggc gcaccaggta cctgctgcgc aaggccgagg agcgggcgca catcctgcgc
       61 gccctgctga gggcgatgga ccggatcgac gaggtcatca gcctcatccg cgccagtgcc
      121 tccgccgacg aggcgcgcac gggcctgatg ggtctgctgg agatcgacga cgtccaggcc
      181 cgcgccatcc tcgacatgca gttgcgcaag ctggccgcgt tggagcgcaa ccagttgatg
      241 tcggagtacg acgagctcat ggcgcagatc gccgactaca acgacatcct ggagaacgag
      301 gcccgtcagc gtaggatcgt ccgcgccgag ctcgccgaga tcgtcgacaa gtacggcgac
      361 gagcggcgca cgcacatcgt ccccttcgag ggtgacatgc gtatggagga cttcatcgcc
      421 gaggaggacg tggtcgtcac gatctcccgc ggcgggtacg ccaagcgcac gcggatcgac
      481 aactaccgtg cgcagaagcg cggcggcaag ggtgtgcgcg gggcgcagct caagcaggac
      541 gacatcgtcc agcacttctt cgtcaccacc acccaccact ggatcctgtg cttcacgaac
      601 cagggccggg tgtaccggat gaaggcctac gagctgccgg aggcggcccg ggacgcgcgc
      661 ggccagcacg tggcgaacct gctgccgttc cagccggacg agcagatcgc ccagatcatg
      721 gccctgcgcg actacgaggc cgcgccgtac ctggtactcg ccacgcgcga gggcctggtg
      781 aagaagtcgc gcctggagga cttcgactcg gcccgttcgg cggggatcat cgcgatcaac
      841 ctgcgcgagg gcgacgagtt gatcgccgcg cggctgacct tccccgacga cgacctcctg
      901 ctgatctcca gcgacgccca ggcgatccgc tttcccgcct ccgacgagtc gctgcggccg
      961 atgggccgcg cgaccagcgg cgtgatcggg atgcggttcc tggagggcga ctacctcttg
     1021 agcatggacg tcatccgggg cggcgacggc gccaccgacg tcttggtcgc gacggagaac
     1081 ggctacgcca agcgcacccc ggccgagcag tacccggtgc agaaccgcgg cggtaagggt
     1141 gtgttgacag ccaaggtcgt ggaactgcgc ggcaagctcg tcggtgcgat gatggtcgac
     1201 cccgacgtgg acgagatctt cgcgatcacc tccaacggcg gggtgatccg caccaacgtg
     1261 gccgaggtga agcggtccgg ccgtaccacg atgggcgttc ggctgatgaa cctgaacaag
     1321 ggcaacaaga tcgtggcgtg tgcacgcaac caagaggctc aagaggaggc cgaagtcgac
     1381 gacacggtct ctggcgcggt ctctgagcaa ggtgggtctg aggtctagac tgcaccttag
     1441 gtccttttgg tcccgcaggg ttccggtcgc gaaccttgcg ggacgcctct tgcgccattc
     1501 acccgtctca acgaaagtcc agcggtagcg tttctatgtc tgacaagcag cggaacacct
     1561 ccaccaacga atccgacacg gacacgccga cgaccgcgaa ggacgaggcg gtggcggacc
     1621 gggctccggt cgacggggcc gacacggtgg cggtggccac caagtcctcc ttccccggcc
     1681 gggatgagga cgggcccggc caggggccgg agacgcggga cgacgcggtc gaggctccgg
     1741 ccgtgaccac gtcctccggc ggttccgaca ccggtggggc cacctccgcg gagaagccct
     1801 ccgaggagag cgagggtggg gaaccggaag ccggctcccc cggccggggc gccgcgtccg
     1861 aagcgacggg ctcctccgcg acgaagaaga aggaggaggc cgtggacacg cgttccgacc
     1921 aatccaccgg ggacaccgaa gggccggggg gaacagaagt gaccgagtcc aagacggcgg
     1981 ccgccaaaca gccgagcgcc gtgaaggcga cgctgtcgag ccgcagggcg cacctgacgg
     2041 tctcccgcgt ggaaccctgg tcggtgatga agtacagctt cgtggtgtcg ctggtgtgct
     2101 tcatcgtcct gttcgtggcg gtcgtggtca tctacacgac cctgtcgatg ctgggtgtct
     2161 tcgacgagct ctccaacatg atgacggcgc tcctggaggg cgacggcagt gaggacgagc
     2221 tcggcctcaa cccgtccgcg tggttctcgc ccggccgggt cctcggctac accggcgtgg
     2281 tcggtgcact gaacatcgtg ctcatcaccg cgctggccac cgtgggcgcg atgctgtaca
     2341 acctggttgc cgacctggtc ggtggcatcg acctcacact gaccgaggct gagtaggcca
     2401 ggccgcgtcc cgcgcagcgg gacgggagta gagcacctcg cggagcccga gcccctaccg
     2461 gggccgggct ccgcgcagtc ggagcggacg cggggtcatc gcggccccgg gatgaactcc
     2521 tgggccttgc tcttgacgcc ctccttgacg accgcccagg cttccgggtc gcccttgagc
     2581 agcgccgccg tcatactctc catctggtcc agggtcgcgt gcggcgggat gggcggtatg
     2641 gcggggtctg tgacgaactc gaccacgcag gggcggtccg cgttcagcgc ccgtcgccag
     2701 gcgtcggcca cctcacttgg atcctcgatc cgagctccgg ccagccccat gtccctggcg
     2761 atctgggcgt agggcaggtc ggggatgcgc tgtgagggcg tgaaccgcgg tgttccaccc
     2821 atcgcacgca gttcccaggt gacctggttg aggtcaccgt tgttgaggac cccgatgacc
     2881 acacgggggt cctcccactc gtgccagtag tgcgccaggg tgatcagctc gttgataccg
     2941 ctcatctgca tcgcgccgtc accgacgaga gcgatcaccg gtcggttcgg atgagcgaac
     3001 ttggcccccg tcgcgtacgg cgtgcccggg cacatcgtgg ccagggtgcc cgacagggag
     3061 ccgcgcatgc ccgtgcggaa gcgcaggtag cgcgcgtacc agttggcagc cgaaccggag
     3121 tcggacgtca cgatcacatc gtcgggcagc agcggcgaca gttcgtggaa gacacgctgg
     3181 gggttgatcg gctcggcgtc gaccatggca cgccgtccga gcacctccca ccagcgttcg
     3241 acgtcgtcct cgatcttctc ccgccacgag ccgtcggtct tccgttcgag gagcggaagg
     3301 agggcctgta gggttcgggc cgcgtcgccg accagattgc actcgaacgg gtatcgcatc
     3361 ccgagcatcg tcgggtcgat gtcgatctgg accgcccgcg cctggtcgaa ggcgggcagg
     3421 aactggctgt acggcagatt cgagccgacg accagcagcg tgtcgcagtc ccgcatcatc
     3481 tcgtaggaag gccgggtgcc cagcagcccg atggagccgg tcacgaacgg caggtcgtcc
     3541 gggaggacgt ccttgccgag cagggccttg gccacccccg caccgaggac gtccgccacc
     3601 tcggtcagct cccccggtgc cccccgggcg ccctggcccg ccaggatcgc gacgcgttcg
     3661 cccgagttga ggacctcggc ggccctggcc agcccctcgg ccgacggcac tgtctcggtg
     3721 tcggagagcc cgaggctgga gggcaccatc ttgaactcgt gtctgggcgg cgagtactcc
     3781 aggtcctgca cgtccgccgg gatgatgagt gcggtcacgg tccgccgcga gaccgctgtg
     3841 cggatggccc ggtccaggac gttgggcagt tgctcgggga cggtgaccat ctggaggtag
     3901 tcgctcgcca catccttgta cagcgagagc aggtcgatct cctgctggta ggagcctccc
     3961 atcgcgctgc gcgccgtttg gccgatgatc gccaccaccg gtacgtggtc gagtttggcg
     4021 tcgtagaggc cgttgagcag gtggacggcg ccggggccgg aggtggcggc acacacgccg
     4081 acccgcccgg agaacttcgc gtacccggtc gcctcgaacg cggccagctc ctcatgcctg
     4141 gactggatga agcggggccg gtcctccgcc cgtccccagg ctccgagcag gctgttgatg
     4201 ccgtcgcccg cgtaggagaa gacgtgctcg acctcccact cgcgcagccg cttcagcacg
     4261 tagtcggaca ccatgtcggc catggcggtt cctctcccgg gaccgcgatc acgcgacacc
     4321 gtcccgtcgc atcgcaacac cgttggcctt cagtaggtgt gactacccag gtcacggcgg
     4381 tgcattcgtc ttggcagggc cggactccga caccggcccc ctcgcccgtg tgttcgtcct
     4441 ccggtccggc gacgcacgtt tgcccggagc cgggcccggt gagggctctg cgcgggtgcc
     4501 gcacgaccga cgggggaccc catgggcgga cgggggacct cgcaaacgag gatccccgtt
     4561 gacgcgcgct cgcgctccgg tgtcggcgac caccgcgggt tcgtcgagcg cgccgccgac
     4621 ctggtattcc gttacggggg ttcgcccccc gtccgtttca gtgacgttct gcgcaggcac
     4681 gggtcgcgta gcggagagtg acgaggacgc cgccccgctc tcggaacggg ttctcacgct
     4741 ggcggagttc ctcggccgtc gcgccccgca ctggcggcca cccaggtcgg accgtgccgc
     4801 cgtcgtgcgg gacctgcttt cgcggaccga tgctggctcc tggagcgtcc gcgggcggcg
     4861 actgtggccg cgatccacgg tctggagctt ccggagcacc gtgcccctac ctgcgccgcc
     4921 acgcggtgct ggtcccaccc ggcccgcggc acatggagtg gttccacgac cacgcgcgca
     4981 tcgaggcgct cctccgcgac ggcgctgatc cgccacgtga cgtttccccg tggccgcccc
     5041 cggtctgccc ggtcacgggt tgcgtttcag gacggtcgac gccgagcggt aacgcgtggg
     5101 ctgaagcact cggggagccc cataaaatag gaggtgaagc ggggcacgga tcgccgggtc
     5161 ccgctcctgc ccgcacagtg gaaccggttc gctccggtct cgccgatgcg gtagagttcc
     5221 atccggaacg agggcgtata gctcagtcgg ttagagcgca tccctgataa ggatgaggcc
     5281 ccaggttcaa gtcctggtac gcccacccag attttcctgg tcagagcctt gcttctccac
     5341 tcagagagca gggctctttc tcgttcgacc gtcatttgac cgtgggaccc cacggcatcc
     5401 cctgtcagaa cacgtactcc cccggcactg aacggcaccg gccggacgcg aagtcgacaa
     5461 cagatcggat ggttgtgtcg ccccgactct agccggtcac ctctgggtcg gcagtgggcg
     5521 actcgggaac tccagcgggc agaggccgcg ggcgggcatc gccgcgggat ctgtgcgccc
     5581 gccccggaca cacatcaggt gagagtgggc gcagggcgcg ccctttgcgc tggggcgtgc
     5641 gacggtgcac cgtgcatggg tgcccagagc gtcacgcgca tcccactgcg cctcgacagc
     5701 agggcggagc agtagggcgc acggtgccgg tgtccgcaga ctgggcgaag ggcgcgcgcc
     5761 gtcgcgcatg gcatccgtgc tctctgtcgc ccctccacga gcgccgtttt cgctgggcat
     5821 ggacccgccc gctgggcggt gccgtgcgct ggcgggcggc gcacggacta tgcgttccga
     5881 tgccggtgcc cacttccccg gctcgggcca tgcactgggg gcgcactcgg tggagtgccc
     5941 tggtaggtgc ccgcccaccg ggccatagtg cccgccgccc acagggcgtg ggcacggcgc
     6001 ccaaggggtg cgcgcatcgc ccgcccatgt gggcgcccgc ccggtgcgca catgggcggg
     6061 cgcccacatc gcgcccctat gccgtctcgg tagcggtcgg ctctctccgt tccgggaggg
     6121 gcacgcccag aagcttcaag aggtcgaccg tgaccactcg gtaggtcgtg ccgtagcgca
     6181 gcagccgaca ggggaactcg ccgcgcctgg cgagttcgta ggccgtcgtc cgccccatgt
     6241 gcagagcacg ggccgccgtc atcaggtcca cggcggcagg cagttcgtac agctcgtgga
     6301 tggtgaaggc tctgcgatcc tcagccactg gtcctcccat gtgccggttt cctcgtcaag
     6361 gaggagaagc acctggaact gcggaaagtg acaggggcac gtcaggacat gagggtgcgc
     6421 acggcccggt cgtacaccac ctgcacgatc aggagggtat cgatccgtac ccgtttgtcg
     6481 gtggcgtgca gcccctcgtg gaccgggtcg aacccggccg tggctggtag gcccagcccg
     6541 gcaaggtagt tgccgatatt cgacgaaggc ggtgccgccc cgccgtggcg gcagtctcca
     6601 gagcttcgct gaggcggcgg gcggacagga ggtggcggct ccgctgcaga tcgtagggtt
     6661 gggtcatggc gacgaccaca gagtccaagt acagcggagt gatcttcgac ttcttcggtg
     6721 tcctgacctt caatatggtc gaggtcatct cctcattcga ggaccgcgag aaactgcccc
     6781 gaggaacgtt tcttcgtgcg tgggccgacc agcgaggaca agaactcttc caacagctcg
     6841 aactcggcca gatcacgcaa gcggaatgga acaaggggtt cgccgccctg atcggggtcg
     6901 cccctgacga cctgatggcc cgctacctcc atgacgcctt ccccgcttac cagatgctca
     6961 aggtcgcacg gcaggcacgg caggccggga tcaagacggc ggtgctgtcc aacagtctcg
     7021 gccgggaacc ttacgatccc tacgcgggct tcgacttgca cggcaccttc gacgaggtgg
     7081 tgttctccac cgaccacggc atccgcaagc ccgatcccga gatcttccgc ctggtcctgg
     7141 acaagctcgg tgtggcggcc caacggtgcg tgttcgttga cgacagcgaa gacaaccttg
     7201 ctgccgccca ctggctgggc ctcaccccgc tcttggcgtt ggacgaggac gtggcggccc
     7261 cccgcctgcg ccacatgctg gacctacccc acccgtagga actcgcgtac ggccgtgtgc
     7321 gacgtggagc tggtgggcgc actccttctt cgccccggtt ttcgagagcg ctcgggcagg
     7381 ctggacgtgg gggcatgcgg agtccccatg aagtcggtcg gctaccgaac ctctcccttg
     7441 cggctcccgc aagccagatc acgtccaccg gtacaccccg gccacgcgcg gcctcgacgg
     7501 cgtcgcccgt gccgcccttg ccgttcgagg tcctgctgtt ccagaccgcg gagagccggt
     7561 cgatcccgcc gggcacggtc tcgttagcgt cctcgtaagc ggcgcggccg acgctcttgt
     7621 gcggcatgta ccgcacgagc gtggagcgca tcagcaggcc gtcgaaccgg tccaggttgt
     7681 ggggcttgac cttggcctcc aggtagtcga cggagggcag gacgacttcg agcagtccgc
     7741 cgaccgcgag cacggcttcg gcgaagagct ggtccgctcc gcgtgccaga caggagacac
     7801 cggtgagcgc gccgtcagcg tagggagcca gagcctcgtc cagggcctta cgcaccgcgg
     7861 cgaccctgtc agcctcaggt ccgagtgacc ggtgacgtcg aacagcgact cgcccacagg
     7921 actccctgaa caccgaagga gtattcccga gcgtgaatac tcccggatga gttgaccgtc
     7981 gcccgggcgc tctctaccgt gaattctcga taatgccata cggaaaggat gattcatggc
     8041 acttcggaaa ctttccggtg attgcaaccg gaacgactgc ccaggtgtgt tctccaccgg
     8101 aacgggaacc gtgatcgtcc agggaccgct gttgaaggcc accgaagaac tcaccctctc
     8161 caccggtgag gtggccgtcg agatccccgc ccacctcatc gaggaggccg cccgtgcgct
     8221 tggaaggtga cgcctggcag gagttcttcc actccttccg ccgggaggcg ttccggctgg
     8281 agaccctgcc gagctacaca gtgcccgagg aagaggacga gctgcgccgt ttcctggccg
     8341 gagaagcacg gcccgccgag gagctgcaca ccgacaccta cctgatcaag gtccgcgagc
     8401 acgtggaagc cgggcgccgg atgcgcagag tccacaccct caccagccct gtcggcgacc
     8461 acctgcggtt ccagttcgag tgggggtacg ccttcagcgt ccaggcggga gaggaggtca
     8521 acatcctcga cttcgccacc acccccgacc ccggccttcc ccgacaggac ttctggctct
     8581 tcgacgacac gcacgtggtc ctcatgcact acgctgccga cggcacccag accggtcggg
     8641 aactgctgga ggacaccgac cccgccccct acgtccggta caaggacctg gccctggagc
     8701 actccacccc cttcaccgag tactacaagg tccgctgatt gacccttgag cccgagaacg
     8761 ccgaccggca gcgcggcgaa ctggccgacg ctctgcgccg gctccgccgc tctgccggga
     8821 tgaccggtgc gggcctggcc gcccgcgccg gtatgagcca ggccaagatc agcaagatcg
     8881 agaacaaccg catccgccct tcccatctgg acgtcgaacg catcctcacc gccctcggcg
     8941 tccccttgga aggacaggac ggggtgcgcc tgctggagct ggcgcgggtg accaactccg
     9001 actaccaggg gttccgcacc gcgctgcaac gcggtttggg ggagctgcaa cgcgacttgg
     9061 ccgccattga gggcgcggca accacgatcc gctacttcct gccgtgcatg atcaccggcc
     9121 tgttgcagac ccccgaatac gcgcggcaga gtctggcgca cccgctggtg aaccgcggtg
     9181 cggagtggca cacggccctg gcccgccgac tggaacgcca gcaggccctc taccagccgg
     9241 gacgacggtt cgtgttcgtg ctgaccgagg cagcgctgcg ctggccgctg tgcccgcccg
     9301 cggtcatggc gttgcagatg gaccgcctcg cgtccttgag tgagctggcc ggggtggaca
     9361 tccggatcgt ccccgcccac cctccagtcc cgagcgggcc gctcaacggg ttcacgctct
     9421 acgatgaccg gctcgtcacc gttgaggtgt tcaccggtga gctggcgctg cgcgacccca
     9481 aggacatcgc ctacagcgaa gagatcttcg acttctacca cggccgatcc ctcgcgcatg
     9541 acgatgctcg ctcgtttctc ggccgattcg cccaggaata tcgagaacga gcgaaaaccg
     9601 acattccgta gcgtgaattt attcccaccc gtgaaagtcc ttcaaacgac tttccggtgt
     9661 gcctagtctt tcctgtgcca gagcccctac cggaaagagc gagcgatgcg cttggcgcag
     9721 gaatcccagc aggacacgca gacccacgcc ccttcgtcac ccttcgttct cgacatccgc
     9781 ctgatcgaga ccagcgacac cacaccactg atcaacctca ccgacgacgg ctgcgggacg
     9841 acctgcccca gcacctgtgt cacgagcgtg tcggactgaa cagtctcggg aaagcgcatg
     9901 gattcgagcg ccgacccgga cacgcaccag gccgcactgt cgatccgtgg tggtcggcac
     9961 cgtcctcttc ggtgccgacc accctcttgg gaggaccacc atggctctgc gctggcaggt
    10021 gaggggcact cccgtcatcc gagcgcccat cacggacggt tcgccggtgt cctggtggcc
    10081 gaacctgcct gggaacgatg tcgacgagtg ggtgcactgg ctcggatgcg tgtgggcggc
    10141 atccgaactg gccgaggcga tccggcacgc ctcaccggac ctggccgccg gcgtggacga
    10201 cctccgatcc cgagccccgg acgggatccg agtgcggcgc gcccgcaaag tgaccgccgc
    10261 tgttgtgcgc tacgtgctgc gggcccggca ccgggccaac cccgttcggc ctctttgcgg
    10321 gcatcgcccc ggcggccttc gctgacgcgg cgtcggtggc atgggggcac gatcaccatg
    10381 ctgtggcctc ccccagcggg gagtggatca ccgagatcac cgatcacctc gtggatctcc
    10441 cccaggtgcg ccagcggctg ttcctggccg ccaaccacac cgcctggcgc acacaggacc
    10501 atctcgtggt gccccagcac gcgcgccccg ccccacccca tcctcgggcg gccacggccg
    10561 aggtagagat ccgtctgacc ggtgctgtcc gactcgtcct ggatgccgcc caaaggcccg
    10621 tgccgtgggc cacactggcc gcgaagctca ccgccgagta cccggacgaa cccgcccaga
    10681 gcgccgagaa cctgctcacc cagttgatcc gggcacgggc tttgctgacg agcctgtccc
    10741 ccacgtcggt cgagaccgac ccgttggcct acctggccag agccctggac ggcatggtcg
    10801 aagtctcacc gccggtccct ctcctcgatg gcacccgctc agtggtacgg atacgtcacc
    10861 gtcacggcag tggcccggct gtgcgggcgg agtccatgaa ggcggcgcgg cacctgtgcg
    10921 acaccgggcg gacggggatc gacgtacgcc tcgatgccac cgtctccctg ccggccgaag
    10981 tggtgtacac ggccgagaag gccgcgcaca tgctcaccgt cctgtccgcg tatccagagg
    11041 gtattcccgc ctggcgcggg tatcgggacc ggttcgcgta ccggtacggc accgatccgg
    11101 tgcctgtggc cgaggccgtg cacccgtcca ccggcctggg gtttcctcac agctacacct
    11161 ctacgggaag cgaagcaccc gcagcggccc tcagcgtgcg cgaccggtgg ctgatgggcc
    11221 aggcccagga cgcggcgctg acggggcgaa gggaggtccg gatcgaggaa ctgctggccg
    11281 cccaggaaac cgtgtactcc tcggccccgc ccgagaacac ggagttgaac ctgcgtctgg
    11341 aatcgccgtc gcgtgcggcg ctcgacagcg gccggttccg actcgtggtg ctgggagctt
    11401 cgcgcagcgc gggcacgatg gcgggccggt tcgccgcgtt gacggggatc gaaaccgact
    11461 tggccgaggt gctcaccggc tccggaccgc tgccggtgca gatgtcgttc cctccgcagc
    11521 ggtccggcag cgtgcccgtc acccgggccc cgagactgct caagcacgtc ctgcacgtgg
    11581 ccgagtaccc ctccaccggt acggacgccc tcaccgtcga cgacctgttc atcggagacg
    11641 acggcacgga actgttcctg tggtcgcgct ctttgcaacg cgcggtcgtc ccagtggtgc
    11701 cgcacgcgct gaacctgcgc cacgccccac cgctggcccg cttcctggcc gaacttcccc
    11761 gcgccgggaa gacggtcgtg tccggattcg attggggagc cgcctccttc ctgccgttcc
    11821 tgccccggct gcggtccgga agggtggtcg tggcgaacgc ccggtggcgg gtcaccgcgg
    11881 cggaccttcc tcccatcacg gcggcgtggc cacgctggca gagcgcatgg caggcgtggg
    11941 cgcggagccg gaacctcccg gccctggtcg agctgggcga aggcgaccag cggctacgcc
    12001 tggacctcac ccaaccagga cacctgttcc tgctccgcag tcacctgaac aaggaaggcg
    12061 cgaccgtgct caccgaagcc cccgcacccg actcggcagg atggtgcgac gggcgtccgg
    12121 tggagatcct cctccaactc caacggaagg ggacggtgtg accgcgcctc tcatcgacgc
    12181 ctccgctgtc gcaacccgcg ccgccgacca cctggctacc cccgaccagg ggcgggcact
    12241 ggcccaaaac cgctggtggc ctcagtccct ggcccacgga gccgtcgggg tggcactgct
    12301 gcacatcgag cgggcccgta ccggccacgg cccctgggaa cgcgctcaaa cttggctgga
    12361 atgcgccgtc tccgatgggg tggacgcctc acccgaggct cacctgtact acggggcgcc
    12421 cgccctggcg ttcgtcctgc accaggccgc cacggtccac ctggggtatg agcgggagct
    12481 ggaacagctc gacgcagccg tggcgcgaat cgtcgctgcg cgcctggaac aggcacacgc
    12541 gcgtatggac accagaggac gtcttcccgt gctggccgag ttcgacgcca tccgtggtct
    12601 ggccggactc tcggcgctgc tgctgacgcg cgactcgtat caggacctgc tgaggcgggc
    12661 gctggtctac ctggttcggc tgaccgaacc cgtcacggcg ccggacgggc agcagacgcc
    12721 cggctggtgg gcttcggtgg acccagcggg gaaggagtcc ccggacctct tcccaggcgg
    12781 gcacgccaac accggcgtgg cccacggcat ctgcggaccg ttgaccgtcc tggcgtcggc
    12841 tctgcggcac gggatcgagg tcgacggtca tacccgtgcg atcagccgca tcctcgactg
    12901 gctcgacttg tggcagcgca ccgatccgga cggggtgtgg tggccctact ggatcaccgc
    12961 ggcccaacac cgtggtgagg aggagccggt ggggccgcag cgcccatcgt ggtgctacgg
    13021 ggcggccggg gtcgcccacg cccagctcct cgcggccgat gctctcggcg acacgaaccg
    13081 ttcgatgaac gcccaggcca cactcgcgcg caccctcacc cctcagagcg cggtggggac
    13141 gaccctggac acctccctgt gccacggcta ctccggcctc gccctcctcg cgcacgccac
    13201 cggtacagcc cgcgttcccg ccctactcgc cccaacggcg gaagggcacg accccgacga
    13261 cgccgtccgc cgcctcctca cccgcaacgg catcggactt ctggaaggag cggccggcac
    13321 cgccacggcc ctgcacaccc tcaccaccga cccgaacccc ctggggtggg cctcgttcct
    13381 gctcatcggc tacgccaagg agcgcgttca tgcgtgacga gcatccacag accctgatcg
    13441 agtggcccga ttgggcgacg gccgaacaca cggccgccca acacttgggg ccgatcctcg
    13501 gcctcggccg acgccgaggg cttctcaccg gctggtggtt catccgcaag aagccctact
    13561 ggcggctgcg ctacaccgga gggcaccgag cccgccgatt cctcgacgcc catctcgaac
    13621 gccttcaccg tgcagagtcc gtctcagcgt gggcgcacgc catctacgag ccggagaccg
    13681 gggccttcgg cggacaggcc gcaatgagcc tggcccacac cctgttccac gccgacagcc
    13741 gccacctgct cacctatctg gcccacgtcc acacgaaccc gtccacagag ctgggccgac
    13801 gcgaactcgc cctcctcatg ggcggcgcct tcctgcgcgg cgcccgcttg gacgccttcg
    13861 aacaggccga cgtgtgggag aaggtcaccg ccctgcgccg cctcccccaa cccttcaccg
    13921 ccgatgaacg gctgctcgca cccgcccgca ccctcacggc cctcgatccc cgagctgtgg
    13981 ccgctaccag cccgcacacc accgcctggg cacaggagtt caccgcggcc ggagccgtcc
    14041 tgtcccgcct ggcagccgaa ggcagactca cccggggcct gcgggcggtg tgcgcccacc
    14101 acctggtctt caccttcaac cggtggggac tcacctacca ggaccaacat gtgctgtcca
    14161 acctcggaaa ggccgtcatg accgacaccg ccgacaacgc gcccgcctcg cccgagaccg
    14221 ccgagacgct gcgcgaggac ctcatccgaa agctgcgcga gaacggctct atcaccacct
    14281 cggaggtgga ggacgccttc cgtcgcgtcc cgcgccacac cttcgtcccc cacgccaccc
    14341 tggaggaggc gtacaccaac gctccggtcc acatcaagca cgatgacgac ggcgcctcga
    14401 tcagttgcgc ctcccagccg ggcgtggtcg cgctcatgct cgaacaggcc gccctcgccc
    14461 ccgggatgcg ggtgcttgaa ctgggctccg ggaccggcta caacgccgcc ctgctcggcc
    14521 acctggtcgg agaaggggcg gtcaccacca tcgacgtcga ccaggacctg gtggacggag
    14581 cccgcacccg gctcaaggac cacggcgcca ccaacgtgac ggtccacctg ggcgacggtg
    14641 cgctcggcca ccccggcggc gcaccctacg accgcgtcat cgcgaccgtg ggatcccacg
    14701 acgtgccacg cgcctgggtg gaccagctcg cccctgacgg caggctcatc gcccccgtac
    14761 ggatcgccgg ggacgtcaac cgcagcatcg tgttcgagcg tgacggcgat cggtggcgct
    14821 ccgtggacag ccaactgtgc accttcatgc ccctgcgggg cggaggcatc ggcgatgacc
    14881 cgcgccgcgt cctctccctg gaccgggacg gcacggtcca gatccaggcc aaccaggacc
    14941 agaccatcac cgaagcgcag gtccacgatg tgctcggcga agaagccacc accgtctgga
    15001 ccggggtgac ctacggcaag agccagccct tggacacgat gtggctgtgg ttggccaccc
    15061 acctggacaa tcgcctctcc cggatgcccc tgcgccgaca cgccgtcgcc aacggactgg
    15121 tcagcccggg actgccctgg ggcgacatgg ccgcagtgcc cgccgccgag cgggggctgg
    15181 catacctcac gctgcgaccg gtggaaggac accggggccg ccatgaactc ggagtcgtcg
    15241 ggcacgcagc cgccgggcgg aagctcgccg agcagatggg cgcccaggcc gcggcgtggg
    15301 aaccccaccg cgacgacgac atctccttcg ccctgcactt cacccctgtc acggaagccc
    15361 cctccgacac ccggcgtgtg ctcaagcgca agcactccat cctggtcgtg tcctggggcg
    15421 aacccgcgtg agcgccgggc agtggttccc gctggtcccc tggccccgcc cacccggaga
    15481 gaagctggcg acgcggatcg aacggatcac caccgctgcc cagaccgtgc gttgcggtga
    15541 gccgagtgat gccgttgccg ccgcggcaca ggtctacaac ggggcggcgc tgatcgcctc
    15601 ggacgtgggg ttgcccgaac tggcgcgtga ctggtgctgg gagcacgccc ggctctacct
    15661 ggcccacctg cccctggacg ccaggatggc gcagcgggcc ttggagccgg tggtcaacct
    15721 cgcccgccta cagattcgtg ccggggaggg aggagcggcc ttcgggatgc tcaccgctct
    15781 ccgcgaagga gtacgcacag cggcctctat cgtgatcgac gggcacgaac tccccttgga
    15841 ccggctcatc gcctcggagg aggaccgggc cgagctgtac cggtgggtgt ggacggtctg
    15901 tcttggagac ggcacccggg ccctggcttc gcaggggcag tggtctcgtg ccgctgaaca
    15961 cgcccagcag cacatggggg tcggggagcg actgttcgac ggccgccaag ccgccgtcat
    16021 cgccgaactc gttgggggcg ccccggaggc tgcactggcc ctggtcgagg gcagcgcggt
    16081 gcaggaaccg tgggagaggg cggtccaaag ggttctggct ctgtggtgcc gtgtcgaggc
    16141 cggtggggtg gaagacggtg aagccgccac cgttctccag cgggttcggg tcgcccagga
    16201 gggtcgtgtc gtcttcagga cccggttggg gatcgccgcc atagaagtgg ccggtggcct
    16261 cagcgaagag gccgggccgc tcgtcgcacc agtggtctcc gcagtgattc aggagcggga
    16321 cgggtacgcg gtccgtgatg tgctccgggc ttgggaggac aggctgcccc aggacagcag
    16381 ggcggcgttg aggacggtgc tggacgagtc agggctcgat tcaggcgtgt tgcaggagat
    16441 gcccctccaa gcgctcacag agtccctcca ggaggcacac ggaagactca gtggagccga
    16501 cctgctcttg atgtgaagca atcctccacg agcgggaggg gagacgtggc ggcccggtgc
    16561 ctgttggcct gggccgtcag gtgtatcaac gccgagtacg acgccgcagt gctcggcgcg
    16621 gtcccgtggt ttcggaggtg gcccgttcgt cgcggcaggg aaccggcccc tggaatccac
    16681 tggggggctg gggccggtcc gtcgtgcttc taccggtggg tgtccctcat ggcgtccagg
    16741 aaagtgatcc actcgcctgc ttcgaagccg aggtgaccgt gcgcgcggtt ctgggtgtcg
    16801 cgcatcaaca cgccctcaag agggttcgtc tcgttgacct caacgcattc gccccgagca
    16861 ccgctgtagg tggacgtgtg ccacccacca gtccggtcga tcactctaag cctcctatgg
    16921 cttccacgat tttctcacga gaggctaccg ggggcagcgc ccatgtctgc agctcaccgt
    16981 atacagcccc cagccgtgca accgggtcgc ctccgagcag ttcgctaccg gaagcatgtt
    17041 cgacttccac gagagtcggc cggtcccgga actcgatcag gcggaaaggt ccggaggcgc
    17101 cgccgtagta cggagcctcc atcggcagga ccaggactct cacgatccca ctgtccgaga
    17161 gttcgagcag gtggtggagc tgttccgcca tgacgacacc ggtaccgaca cgagctctga
    17221 tgaccgactc gctgaggatg gccagcatgc gggggttgtt catcttgcga agcgtgtcaa
    17281 ggcggttgac acggagttcg acgagccgtt cgatctcgtg gtccgtgtcc aggggcgcac
    17341 cgtcccggaa tacctggcga gcgtagtcgg aggtctggag catgccgggt acgagcccgg
    17401 ggttccagaa cttgatcccg gaggcctgtt cttcggcggt cacgaccttg cggtgccagt
    17461 caggatcgtc cgctgcgcgc tgggcttcct cccaacggcg gaggaggtca ccgtttgtac
    17521 ggtacagggc ttcggtttcg tgcacgaagt cccttttggg ggacctgtaa gcgttctcgt
    17581 atttacttat ggttgacgcg ccgtagccgg tctctcttgc tgcttggtcg agcgtcagcc
    17641 ctcttccttc gcgttgcctg cgaagctctc gaccgaaggt gacccaagct gtcagcactt
    17701 tctcaggcat gcatagaact ttacagagat tctctacgtc cctgtacggg atctgccaac
    17761 tttccctcgg tgttcggaaa ggcattgaac gcgtcgcggc acgcttggac gatgaggatc
    17821 cggctagagg agcacgaacg agcagcagcg ggccgctgtg tcgtcccagt gctctctatg
    17881 gaaaggccgg ggaaaccacg aaacagaagt acctcggcag ccgggtcgca gcggctccga
    17941 ggcacggacc caccccgaac gacccgaggt gagacatgca ccagtctatc gctccgccct
    18001 ccgcgctgcc gcgccgactg cgcggaaccc cgaccaggtc gggcctcctg ctcggccccg
    18061 acctcggcca cgtcgccatc gcgcgccgct gggcggcccg ggccacccgc acccgcctcg
    18121 gcctggccga acccctcgcg ctggccgtct ccgaactcac gacgaacgcg ctgcgccaca
    18181 ccgcctccgg cctgcccggc ggcaccgtcc gcgtcgagat cgaccgcacc ggccacctgg
    18241 aactgcgcgt caccgacgac ggcccccgcc tcggcacggc caccacaccc ccggcgatcc
    18301 ccgccctgga ccccttccgg gtgggcggca acgggctgcg cctggtcgag gcggtgtgcg
    18361 cctactggga ctggacacgg aaccccgatg gcgggaccac cgtccgcgcc gtcttccccc
    18421 gatgaccacc tgacccccgc gccgcgcccc tgcctctggc gcggcgcggg atcccggggg
    18481 cggcggacgc ccctgccgct gcctccggca ccccctccag caccacaccg ccgaacgaga
    18541 agggacaccg cccgtgacgg tcctgttgtg caggcactgc ggtagccccc gccacagcgg
    18601 agccccggcc taccgctgca cctgcatccc cgcccacgta tggcagagca cggaagcggc
    18661 ccgagccgtg cgcgccctga acctgtccaa ggtcatccag tacctgcgcc gccaccccga
    18721 cacccgccac ctctcccagg cggccctggc cgacatgtgc gccctgtcgc gggcgatgat
    18781 ctcccggctg gagaacggca ccaccgccac ccgcatcgac cgcgccgtca ccgccctggc
    18841 cggactcgga gcgccccagg tccccggcga gatccaccag ccccacctgg acgaggatcc
    18901 gccgcccccg gccggccccc gcgacgacta cggcgtgccc tgcgtggtcc tcaccagccc
    18961 tgcccccatc cgcgtccacg tccgcgaccc cgaccccgac caggacaccc ccgaccccga
    19021 tggcggtgtg cccggcagcg tcgtcttcgt cgcccacccc gacgacccgt gcctggtcgt
    19081 cgaccacggc accgcctggg gcgtgaccaa caccggccac ggggcgaccg cctggttcgc
    19141 cctgcccacg cactggcccc aaacgccgca tcccccggat gccgcacccg agcaggaaca
    19201 gcccgccgag cctcccgaac cgccccgcga acagagctga acgcccgccc tgcggcccgg
    19261 ggccacctga accggtgcgg cggggacgca cccgcccggg tttcccctgc cgcaccacac
    19321 cccgggcctt gtcggctcag caaggcccgg gtcacgccac cccctgttcg tgttgaggag
    19381 taccgtgacc gccgcccagg ccgagcttga gagacgacac cgcgcccccg cccgctgccc
    19441 ccgctcgtgc accgagtacc tgaacacccg gtacggcatc agagcaccac ggcccgggcc
    19501 gctgttccgg gacgacccgg tgaagacggc ggaagctgtc ctgcgagggc acggcatccc
    19561 gttgcgcggc ccacccgacg acgagttccg tgaactgtcg gctctggtgc ggctctacct
    19621 ggcgcgacga tccggctgag gatcgcgtcc tcacatccga ggagtgtcga gaaagccatg
    19681 gcccgctcac tcgaaccgcg cagacgggtg tcctgtgacc cagcggtcct ggccgcccgc
    19741 tcagcgaaga agcgagaaga ccgttgccgc gacggccgca ccgaacaccg cgcccacgac
    19801 ggtctgtgcc ggtgtgtggt cccccaggcg tacccgcgac caaccgacga gcgcgatgag
    19861 cggaaccgtg gccgccatca ccgccccata ggtgagcacg aggacggtcg agacaccgcc
    19921 ggccacggcg gtgtgaacgg agaccttcca cttcacggtg atcgccagag tgatggccag
    19981 tgccgtcagc atcgcgacga ccagagcgaa cagttcccgg ggcgcgtcca ggagcacgag
    20041 cgtcgcgatg ccgagtgtca cgcatccgat gacgatcagc agcggaacga agcgctgacg
    20101 gcgttcccgc acatggcggt cggtccacca accgattcgg gctccgagga tgaggatcgc
    20161 gtaggggacg atgccgcaga acagtgcggc gaggagaccc cagagaatcc cggcgggggt
    20221 ctggtcgctg taccagccga tcgcgagaag gacgaccacg acgaggacac cgggcgccag
    20281 catctcagtg acggctcggg ccacccggta cccgaccgtc gtcgaggggc gtcacggcgg
    20341 ttcctccgca ctcgtcggta ctgtcggcgg gaataggggg gaaggacgcg gcgagttcta
    20401 gcacggctag aggaccggtg cacacgggca acgctccatc ggcgtacttc ggtgaacgcc
    20461 tcggtatccg ctccggacag gtgagaggtc tcggcaaggc ttgccgacgt gtcttgccga
    20521 cccttcggaa aacctctgtg atcagggaag acacccttgc cggcggccag tggaacacag
    20581 tggtacgggg cggaccgtgg tggtacacgg gcatgaccga cctggtacgc cggggatcgc
    20641 ggcacgggac cgaggtgctg cgcacccgcg gggaaccgtc tccgaggccc tggggcctgc
    20701 gcgatatcga cctgaacgaa gacgagtagc cgtctgacgg tgggcatcct cgacgggttg
    20761 acccaatggt tgactggggg ctacaggggt cgctacaggg gcgggttcac cctttccgca
    20821 gccgccggac gcaccgaagc ccgacagggc aggggatgga gcgctgtcgg caaactccga
    20881 catcttctct ctcacctcat gtaagagaga agaacgcttg tctctgatcc tcccttctcc
    20941 ttgatcccag tagagcttgc tccttccatg gacacctttc tggatcctga tcacaccgag
    21001 ccattgtgaa cgcgacctcc atctcaccgt ggtgacacac ccgaactcac cttcttcctc
    21061 ctgctccggc tccacccatc cgctcacctg tggaccccga ctcgagaacg ccgctatctc
    21121 ctgtacgcct gcccctgtgc ccgactggcg agggatgcag ggtctggatg cgagaccgaa
    21181 cccttcgagc gggtgctgag acccggaaga cgagcactcc gggtcggtga ggcggcttgg
    21241 cctccatacg ggggagctgt ctccccaccg gagaagtggg caagtccggg agccgaaaag
    21301 acgccgtcga catgtgtcac ataaccgcct ccggcgggct tcctccttgc gacgggatct
    21361 gtcgcccaca gcgaggagga cgagcgcttg ccgatccgca ccaccgaagc cagcgagctg
    21421 gcccaacacg cgctggcggt gctctaccag caccgcctgg tcaccagcca ccagttggcc
    21481 cgcctactca ccccggaggc caactcacgg agatacatgc tccacatcct ccaccggctg
    21541 cggcagcagg gcctggccga ccgggtggtg cccccgggcc gccgcccgca ccgctggttc
    21601 ctcactctcg ccggagcacg cgccgtacag gaggccgggc aactgtcggc gcgcccgtac
    21661 cggatgagcc ccgaacgcgc cgccggaccg ctcgccgaac acatgctggc cgtggtggag
    21721 acgggcctgg ccttcttcgc acacgcacac cgcctggacg acgagttcgg gctcctgcac
    21781 tgggttccgg aggtggcgca ccgctatacc aagggcagcg gcaggttcgc cgacacccac
    21841 gtgatcagcg acgccctgat gcactacatc acggtgcgcc ccgacgggcg ccgggtccag
    21901 taccagttcc tggtggaggt ggaccgcacc accatgcccg tgacacgact ggtggccaag
    21961 ctcgtggcct acgcccgcta cttcgaccac caccccctgc gcaggcgcac gagcgtgacg
    22021 ggcagatcgg cgcgtccggc ctggcaggac cggtatccgt tcttccccag agtgctgctg
    22081 gtcctggacg gagccaacga gcggcgcctg cgcaaccgcg gagtcgacct cgccgcctac
    22141 gcgcggctgc tgccgtacct gacggtcgag cggccggggt ttcgcgtcgg atacaccacg
    22201 atgcccgacc tggtggagca cgggccgcgg gagcggatct ggaccaacct gctcagcccg
    22261 gggcgggacg gggagcagta cacggacttc accctgcgcg cgtgaacgcg tctgagctga
    22321 cggccgggaa cagcgctgtg accagaaggc acagcacgct tgagagccga caggctgttg
    22381 ttcccatggc ccgggggcag actgacacag gcttctccgg cgatcagttc tcgagcgcgg
    22441 gccgtgccgc tttggtgcgg tagccggtga accaggtggc cactgcgata gcggccaccg
    22501 tggcgaggag gggtagccag ggaatcgcag gtggccaggt accccaggcc cacaccgcgg
    22561 ccgtcatcgc cgcgctgcct ccgagcgcgc ccagcaccga ggccgggacg gcgagggcga
    22621 gcaggcgtgc cgcgaccata cggcgtatga aacgcggcgg tgctcccacc gctgccatga
    22681 ccgcgtcgtc tcgggcgttc tcctcggccg aaagcgctcc cgcgatggcc gctgttcccg
    22741 ccgcggtgac ggtggccaag ccggtgatca gccacagaag ggcggagatc tccgtaccgt
    22801 cgtagccgcg ttcgatgtag agctccgcct gtcctcccag atggcggtcg gtagccgcct
    22861 gagctgcctc gatctggtca gcggtgggat cggtgcccgc caccaacaag gcgtcgcggg
    22921 cggtgacggc agccaggccg tgttcgtcca ggtgctgggc ggagatgagg gcgttcggca
    22981 accgtgttcc gtggtcgtcg gtcggcacgg tctccgcgtc catttccacg gcaggccccg
    23041 aagggtcggc tccggggcgg agaagaacac gtccgttgtg ctgcaaggcg tcgtccgtca
    23101 ccaccacacg gccgtctcgg agcgcgcgaa gggcctgctc ccgctgaccg tccccgcgga
    23161 accgggcgga gaccagggcc tcgtcggcta ccgcgacggc ctgtacaggt gtgaggccgg
    23221 gcggcaggtc aggagagcat ccttccgtac cgtcgcctgc cagcgcacat ctccacgtgt
    23281 cgttgtccag gaccacacgg gtcggttcgc cgtcggtggg cagtgcggcg taggggatcc
    23341 ggaccacttt ggcaccaccc agctcccggg tgagtgggct gagcacggag tcgtcggccg
    23401 gaagggggcc gctcaccatg gcttggccgt gcagaaggcc ggggacgtag gtcgcggcgt
    23461 tgtactcgtc ggcgctgcgg acgagtactc cggccaccga ggcactggcc gtgaccgcgc
    23521 agatcgccac cgcgagggga agtgaccgtg acatggtgcg ggccggagtg cgcagcgcca
    23581 ctcgcgtccg caccggcaga cgcgccgcga ccacggagga cagcgacagt agtagcccgc
    23641 acgatcccag cagcccgagt gcgtagacga cacctccggc accggccaga ggtatcgccc
    23701 cgatgacggt gccgccgatg agggcagcca gacccgctac ggctgcggta ggccagatcc
    23761 accttctgcg ccggggaacc gtcccaccgg ggacgtcgcg cagcatgtcg accggtcccc
    23821 acctcgcgct cgcccgcgcc ggcaaccacg cggcgaccag accgcccacc agggacagag
    23881 ccccgatcca gacgagttgg tccatgcgga tcaccggtgc tccccaggac aggccggtga
    23941 tccgttcccc caacggttgg gcgagcaagg cagcgacgac tcctacgacg gtccctgcca
    24001 gagcaccggt cgcagccacc agtacgccgt ggagcagaac cgtgcggcgc aacaggcccg
    24061 gtcgtgctcc ggcggcggcc aacaacccca tgtcccgtcg acggcgttgg gcggagaggg
    24121 tgaacaccgc cgcggccagc agcgcgacct ctcccagacc cagggcggtg aacagtagca
    24181 ccgcacggtc gtcgtcgcgt gtggtgtcct cggccgccgg gggtgccccc ggtgtcgggc
    24241 cggaggtgcg cggatccacc gtgaaaccga gtggaccgag caactgggtc agttccggct
    24301 cgcctgtgcc cgaaggcaga ccgcccagga gccacgggcc gttgtcctcg gcagaagcgg
    24361 acagtaccgg atcctgtggc agaccgacga ggaaatcgcg gtcatggtcg gtagggtcga
    24421 ccacgaggcc ggtgacggtg acggtgtgtt ccgagcccac ggtcacgcga tcgccgatct
    24481 ccacctgtga accgtggccg agatgtcggc tcaccaacac ctcaccggtc tgttcgggcg
    24541 tgcgcccttc ggcgacctcc aacagaccgt ccgtcaaagg gtcggacaga tccgccagaa
    24601 ccactgaagt ggggaccgga ccgtggcccg tgtccgccgc tatcaccgag ccggcggccg
    24661 ggacgatcct cacaccctcc ggcagcgcgt cttccagctc cgcggccgaa gccttccccg
    24721 atgccgtgta cacgcgagcc tgggccgccc ccatggcggc gacctgttcc tcctcagcag
    24781 tgggaacggc agtgctgtac aggatctgcg cgaacacggc gaccgctacc gggagtccga
    24841 gcagccctgc tcccgccagg gcacgcctgc cgtccttcct gaccatgcgc catgccagac
    24901 gcaggctgag aggctttctc acagcgggtc cttccggtcc tggccgagta ctccgtcgcg
    24961 catcaccagg acccggtcgg ccagcgtcga ccactgttgg tcatgggtac ctatcagtac
    25021 acccgcgccg tgctcgcgtg cccggccgac cagcgcatca cgcacggccc gggaggacac
    25081 cgaatccagc gcaccggtcg gctcgtcggc cacgaccagc ctccgggagc cgatgagtgc
    25141 acgggcgatc gccacacgct gccgctgccc gccggacatc tgccccggat agcggtccgc
    25201 cagttcggcg atcccgagtt cctccaatgc cgtgagggca cgctgacgtg cccgacgggt
    25261 cccctctatc tccagaggga gcgcggtgtt ctccagcgcg gtgagtacgc tcagcaggtt
    25321 gtactcctgg aacacgtaac cgatgcttcg gaggcgcagg tccgcgcggc gcttggcacc
    25381 gataccgacg acgtcgttgc cgtcgacacg cacggctccc cgagtgggct c
//
