LOCUS       NZ_AZXF01000012        10294 bp    DNA     linear   CON 21-OCT-2024
DEFINITION  Nocardiopsis sp. CNT312 B042DRAFT_scaffold_6.7_C, whole genome
            shotgun sequence.
ACCESSION   NZ_AZXF01000012
VERSION     NZ_AZXF01000012.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Nocardiopsis sp. CNT312
  ORGANISM  Nocardiopsis sp. CNT312
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Nocardiopsis.
REFERENCE   1  (bases 1 to 206696)
  AUTHORS   Jensen,P., Huntemann,M., Han,J., Chen,A., Kyrpides,N.,
            Mavromatis,K., Markowitz,V., Palaniappan,K., Ivanova,N.,
            Schaumberg,A., Pati,A., Liolios,K., Nordberg,H.P., Cantor,M.N.,
            Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            assembly :: Velvet v. 1.1.04; ALLPATHS v. R41043
            investigation_type                :: bacteria_archaea
            project_name                      :: Nocardiopsis sp. CNT312
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi14643
            Funding Program                   :: DOE-CSP-ICBG 2011
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Velvet v. 1.1.04; ALLPATHS v. R41043
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Unknown
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000515115.1-RS_2024_10_21
            Annotation Date                   :: 10/21/2024 21:26:24
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,296
            CDSs (total)                      :: 4,234
            Genes (coding)                    :: 4,144
            CDSs (with protein)               :: 4,144
            Genes (RNA)                       :: 62
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 90
            CDSs (without protein)            :: 90
            Pseudo Genes (ambiguous residues) :: 0 of 90
            Pseudo Genes (frameshifted)       :: 23 of 90
            Pseudo Genes (incomplete)         :: 74 of 90
            Pseudo Genes (internal stop)      :: 5 of 90
            Pseudo Genes (multiple problems)  :: 12 of 90
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:21:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 98306
            Orig. end                         :: 108600
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AZXF01000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..10294
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10294
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10294
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5294](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5294)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            974..1540
                     /locus_tag="B042_RS21925"
     CDS             974..1540
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017588551.1"
                     /locus_tag="B042_RS21925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_036553850.1"
                     /transl_table=11
                     /translation="MTVSDVRTGPLRRAVAPLNARWHRISLRVFMVIVLAHWAEHIVQA
                     VQIYVLAWPVPEARGVLGMPFPWLVTSEWLHYGYALVMLVGLILLLPGFGGRSRFWWQT
                     SLLIQVWHHFEHLLLLVQTFSGAYIGGAAAPTSLVQLVIPRVELHLLYNSLVFVPMVVA
                     MVRHTWPTERELEEMDCDCADEERA"
     gene            1537..1974
                     /locus_tag="B042_RS0104215"
     CDS             1537..1974
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B042_RS0104215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_051415463.1"
                     /transl_table=11
                     /translation="MRARARRGGAFTAVFLLVAGMLVYMGASNMDRSIRAARAEGEPGT
                     FTASHVDCVQHPGHESCTCYGTYVPDDGGPERGDIYLYGRDRETCLIGEPDEAVDIGAA
                     SRVYGPEGSNEWMMTAAVIAAGVAMGGWAVRGWWTADRKRG"
     gene            2036..2851
                     /gene="dapF"
                     /locus_tag="B042_RS0104220"
     CDS             2036..2851
                     /EC_number="5.1.1.7"
                     /GO_function="GO:0008837 - diaminopimelate epimerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013151729.1"
                     /locus_tag="B042_RS0104220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminopimelate epimerase"
                     /protein_id="WP_028647199.1"
                     /transl_table=11
                     /translation="MRFAKGHGTENDFVILPDPDGELDLTEGAVRLLCDRRAGIGGDGV
                     LRVVRTRALGEGLPPAARSAEGTEWFMDYRNADGSVAEMCGNGARVFARYLLHAGLVAG
                     DRFGIGTRDGAKEVRIADDGGVTLDMGRVRRGGPSSAKLARQAVHGVRVSVGNPHLACE
                     VEGPVSGVDLTAAPELDAEAFPEGANVEVYTQSGPGVLDMRVYERGSGETRSCGTGIVA
                     AAAAATPEGEGATWRVRVPGGACTVFLDADGARLHGPAVIVAEGETSLV"
     gene            complement(2859..4928)
                     /locus_tag="B042_RS0104225"
     CDS             complement(2859..4928)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608504.1"
                     /locus_tag="B042_RS0104225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_028647200.1"
                     /transl_table=11
                     /translation="MPHRTTAFAHVALLLLAALISALVLSGSELRMPTAGEHSDVVWIT
                     ENPRGTEAADVAPTLTRVAAEQGAAIGYTFPDVDEPDTLWHMYLVLDDPDSPRADWLTD
                     GFPTFGRTMELSVHPLEEYTGTSPRGYYTLFGPPESEQALEEALAEHGLSQAPGATESD
                     QWFLLTGGALSNTLAATLLVVVTSASVGVLLDSRDYAVQRLQGRSYTRILIRDLVRIAR
                     LWAVALPSAAAAVLAVLGLYNGWSRLDSYALTTAALLVPLLAAALATHAAALGAVHLTA
                     VLPALKGRLPARTATTAVYLVRVPVLLLVLSVLGAVVHHTATVREQQAGLELFARTGDT
                     SLVTVNGSVSLDEHGTMDERLGPWLRRVDTGGGLILSDQVPPESVLPLGGTRPGFDLLV
                     VNDTYLEAEELLSPSGERYGATPSGGPVRALVPERHSGFREDIASAAPAWIGALSGGAG
                     PEAEVETFPLADGQSVFTYGSRPPAPGASPPLLHDPVVLVLPNGAVLSDTSYVGAASRA
                     ALLFPDPGIVERARRDPATAEYINTVPTVESRAVADHAATLTTLRTETFNLVAAVAVLL
                     LTGVAACVIHARTRAQVIFARHISGWSFAATHRWFLLLEAAIALGFVGWAAWTTASTLR
                     ALRDPTVPTLPAYIPTSGLEPLYALGTAAAGLALTLGALTVFHRRIVREGASQA"
     gene            complement(5001..5294)
                     /locus_tag="B042_RS0104230"
     CDS             complement(5001..5294)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014912390.1"
                     /locus_tag="B042_RS0104230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_028647201.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 2.4e-18,
                     bitscore: 60.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLKKAAVTLLIGAGVGLGAAGIASAATSYVGGGTWSHGVTKTT
                     VYSIYHHSTRCHGATAVGTYTDRTPSTLPGYTAQAYAPPRWWGGNEAYWNLC"
     misc_feature    5277..5291
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.18"
                     /tool="antismash"
     misc_feature    complement(5418..5431)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.4"
                     /tool="antismash"
     misc_feature    5420..5438
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(5424..5442)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 19.72"
                     /tool="antismash"
     misc_feature    complement(5495..5508)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.06"
                     /tool="antismash"
     misc_feature    complement(5495..5509)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     misc_feature    5531..5545
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.32"
                     /tool="antismash"
     gene            complement(5589..6803)
                     /locus_tag="B042_RS0104235"
     CDS             complement(5589..6803)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017587520.1"
                     /locus_tag="B042_RS0104235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding protein"
                     /protein_id="WP_028647202.1"
                     /transl_table=11
                     /translation="MRTALAESGSRVRPGGPGDAVGGVVPALVVRPADTAAAARVLAAA
                     DRHGAASVFRGGGTALDWGAPPCSADLLVETAGLRGIEHTAEDLVVTVGAGTPVSELVD
                     VLAGAGQRLSVDPVRTGGTVGGMVATGVCGPRRLLHGALRDLVIGMTVVRADGVVARTG
                     GRVVKNVAGYDLAKLHTGALGTLGLVASVTFRTHPLPPALRTVTAPVPSAARGERMAAA
                     LRARTVVPSAVALDWPAEGRADLTVALEGTAEGMAARVAGTVAALGGGEVADRLPAGWG
                     LVAEQGTLVFLSGPPAASVAASARTCELAGAVGARVRVRGSAASGALYAAFAPGTGAAA
                     VGEVLAGVRALPEWSATVLRAEPGVHGAGIDLWGTVPGLPLMRAVKDAFDPGRRLAPGR
                     FTGGI"
     gene            complement(6853..8316)
                     /locus_tag="B042_RS0104240"
     CDS             complement(6853..8316)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017598687.1"
                     /locus_tag="B042_RS0104240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_028647203.1"
                     /transl_table=11
                     /translation="MSEALTTLIPLLREACGGDAVLTGDEERRGFDHDGITHRRSLPGV
                     VVLPTTTEQVSAVLALCAEHGVPFVPRGAGTGLSGGALPHREGVLLSTARMRRVIEIDP
                     DNECAVVEPGVPNLDVTTAAAPHGYYYAPDPSSQAVCSVGGNVAENSGGAHCLKYGFTA
                     THVRGLELVLPGGETVRLGGKAPDAPGYDLIRAIVGSEGTLGIVTRVTVGLTRLPERTV
                     TLLAAFDSLDSGGAAVSAIVSSGLLPSAIEMMDALSVEAVNALMDTGYPTDAAAVLIVE
                     LDGPAPDVDAHLAEVRDLCAEHGARATRTAADGGERARIWAGRKAAFDAVGAMSPAYVV
                     QDEVVPRTALPRVLRAIADLSAKTGIPVANVFHAGDGNLHPLVMFDDTDPDGHRRAEEV
                     SAAILDLCVAHGGSITGEHGVGTDKACSMPRMYSPDDLDTFDRLRRAFDPRGIANPDKL
                     LPTPRLCGERPGVRRGVHPLVESGRATQF"
     gene            complement(8429..10033)
                     /gene="aceB"
                     /locus_tag="B042_RS0104245"
     CDS             complement(8429..10033)
                     /EC_number="2.3.3.9"
                     /GO_function="GO:0004474 - malate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006097 - glyoxylate cycle [Evidence IEA]"
                     /codon_start=1
                     /gene="aceB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019606883.1"
                     /locus_tag="B042_RS0104245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="malate synthase A"
                     /protein_id="WP_028647204.1"
                     /transl_table=11
                     /translation="MGATPGVEITGPLHDRFDEILTDDALALVAELHRAFEERRQELLA
                     ARKERQERISAGEDLDFLPETKHIRDDTGWKVAAPAPGIEDRRVEITGPTDRKMTINAL
                     NSGAKIWLADFEDANTPLWENMVQGQLNLRDALDRTIDFTSPQGKSYALKEDSALATMI
                     VRPRGWHLDEKHILVDGQRTSGGIVDFALYFFHCAQRQLAKGKGPYFYLPKMQSHLEAR
                     LWNDVFVLAQERLGIERGTIRATCLIETIPAAFEMEEILYELREHSAGLNAGRWDYLFS
                     IIKTHRTRGRRFLLPERNAVTMTAPMMRAYTELLVKTCHKRGAHAIGGMAAFIPSRKDE
                     EVNKNAFAKVRDDKSRESGDGFDGSWVAHPDLVPVCREIFDGVLGERPNQIDKQRPDVE
                     VSAADLLAVDKTEGGVTLAGLRGNINVALQYLATWMGGTGAVAIHNLMEDAATAEISRS
                     QIWQWLHNDVTLDDGPKVTAGLVKQIIDEEMANIRQGLGKAFDEGLYQQAGELFAEVAL
                     ADDYADFLTLPAYERMP"
     misc_feature    complement(10065..10079)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.0"
                     /tool="antismash"
     misc_feature    complement(10067..10080)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.46"
                     /tool="antismash"
     misc_feature    complement(10150..10164)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.19"
                     /tool="antismash"
ORIGIN
        1 ccgccgggga gccgaccgcg gcgcccacca cgtccggtcc cgcgccgaag ccgccggtgg
       61 accggcgcct gaaggcactg cgcatgttcg ccacctccat caccgtgttc accgtcgtcg
      121 ggcacgtgtt cctggggttc gagcagtcgc ccgtcacacc catcgtcgcc gtcctgttcg
      181 cctacgtcct cgatctcgcc ctggagaccc tggacgcgcg ggccgcatgc cggacccccg
      241 ggtaccgggg cggcgtcggc accatggtcg actacctcct gcccacccac atcgccgggc
      301 tggcctgcgc gatgctgctg tgggggaaca cctcgctgtg gccgtacctg ttcgccgtgt
      361 ccatcgcggt gagcagcaag tacctcttcc ggatcccggt caaggggcgc tggcggcact
      421 ttctcaaccc gtccaacctg ggcatcgcgg tgacgctgct gctcttcccg tgggtgggca
      481 tcgctccgcc gtaccacttc accaacgaca cctggggcac cgcggactgg ctgatcccgc
      541 tcgggatcct catggccggg accatgctca acgccaacct caccaagcgg tggcctctga
      601 tcctgggctg ggtgggcggc ttcgtcctcc aggccctcct gcggtggctg ttcctcgacc
      661 acatgctggt ggcggcgctg gcgccgctga ccggcgtggc cttcatcctg ttcaccaact
      721 acatgatcac cgacccgggg acgacccccg gccgcccccg caaccagatg gtcttcggcc
      781 tgacgaccgc gctggtgtac ggcgtcctgg tcagcctcca cgtcgtcttc gggctcttct
      841 tcgccctcgt catcacctgt ctgctgcgcg gagcggttct cgtcgccgcc ccctggttcg
      901 accgccgcac cggggccgcc gaaccgtcgg cgcccgagcc cgccgcggcg gcccgggacg
      961 ggggagcctc ctcatgaccg tctccgacgt gcggaccggc cctctccgca gggccgtcgc
     1021 acccctgaac gcccgctggc accggatctc cctgcgcgtg ttcatggtca tcgtcctcgc
     1081 ccactgggcg gagcacatcg tccaggccgt ccagatctac gttctggcct ggcccgtccc
     1141 cgaggcccga ggggtgctgg gcatgccctt cccgtggctg gtcacctcgg agtggctgca
     1201 ctacggctac gccctggtca tgctggtcgg cctcatcctc ctcctgcccg gcttcggagg
     1261 ccggtcgcgc ttctggtggc agacgtcgct gctcatccag gtctggcacc acttcgagca
     1321 cctgctcctg ctcgtccaga ccttcagcgg ggcctacatc ggcggcgcgg cggcccccac
     1381 gagcctggtc cagctggtca ttcccagggt cgaactccac ctgctgtaca actcgctggt
     1441 cttcgtcccg atggtcgtgg cgatggtccg gcacacctgg cccaccgaac gggaactgga
     1501 ggagatggac tgcgactgcg cggacgagga gcgtgcgtga gggcccgcgc gcgccggggc
     1561 ggcgccttca cggccgtctt cctcctcgtc gcggggatgc tcgtctacat gggcgcctcc
     1621 aacatggacc gcagcatccg ggcggcccgc gccgaggggg agccgggcac gttcaccgca
     1681 tcccacgtcg actgcgtcca gcacccgggg cacgagtcgt gcacctgcta cggcacctac
     1741 gtccccgacg acggcggtcc cgagcgcggc gacatctacc tctacggtcg cgaccgggag
     1801 acctgtctga tcggtgagcc cgacgaggcc gtggacatcg gggcagccag ccgcgtctac
     1861 ggcccggagg ggtcgaacga gtggatgatg acggcggccg tgatcgccgc cggcgtcgcc
     1921 atgggcggct gggcggtccg ggggtggtgg accgccgaca ggaagcgcgg gtgagggggt
     1981 gccgccgcgc cgtcagcggc gcggcggcac cctcccgacg ccctaggatg gcggcatgcg
     2041 attcgccaag ggccacggca cagagaacga cttcgtgatc ctccccgacc ccgacgggga
     2101 gctcgacctc acggaggggg ccgtccgcct gctgtgcgac cgccgcgcgg gcatcggcgg
     2161 tgacggcgtc ctgcgggtgg tgcgcacccg cgccctgggg gaggggctgc ccccggcggc
     2221 gcgctccgcc gaggggacgg agtggttcat ggactaccgc aacgccgacg gctcggtcgc
     2281 cgagatgtgc ggcaacggcg cgcgggtctt cgcccgctac ctgctgcacg ccggcctggt
     2341 cgcgggggac cggttcggga tcgggacccg ggacggcgcc aaggaggtcc ggatcgccga
     2401 cgacggcggc gtcaccctcg acatgggccg ggtgcgcagg ggcgggccct cctcggcgaa
     2461 gctggcgcgg caggcggtgc acggcgtccg ggtgtccgtg ggcaacccgc acctggcctg
     2521 cgaggtcgag ggccccgtgt ccggggtcga cctcaccgcg gcaccggagc tcgacgccga
     2581 ggccttcccc gagggtgcca acgtggaggt ctacacccag tccgggccgg gcgtcctgga
     2641 catgcgcgtg tacgagcgcg gctcgggcga gacgcgctcg tgcggtaccg ggatcgtggc
     2701 ggcggccgcg gcggccaccc ccgagggcga gggcgccacg tggcgggtgc gcgtacccgg
     2761 cggcgcgtgc accgtgttcc tggacgccga cggcgcccgc ctgcacggcc cggccgtcat
     2821 cgtcgctgag ggggagacgt ccctggtgtg aggcaacctc aggcctggga ggccccctcg
     2881 cggacgatcc ggcggtggaa cacggtgagc gctcccaaag tgagcgccag ccccgccgcc
     2941 gcggtgccca gggcgtagag gggttcgagc ccgctcgtgg gaatgtacgc gggcagggtc
     3001 ggcaccgtgg ggtcccgcag tgcccggagc gtgctcgcgg tggtccaggc agcccagccg
     3061 acgaagccga gggcgatcgc cgcctccagg agcaggaacc accggtgggt ggcggcgaag
     3121 gaccacccgc tgatgtgccg ggcgaagatg acctgggcgc gggtccgggc gtggatcacg
     3181 caggcggcga caccggtcag cagcagcacg gcgaccgccg cgaccaggtt gaacgtctcc
     3241 gtgcgcagcg tggtcagggt ggcggcgtgg tcggcgaccg cgcggctctc gacggtgggc
     3301 accgtgttga tgtactcggc cgtcgccggg tcccgccggg cccgttcgac gatgcccgga
     3361 tcggggaaca ggagcgcggc gcggctcgcg gcgccgacgt aactagtatc ggacaggacc
     3421 gcgccgttgg gcagcacgag gaccaccggg tcgtggagca ggggcggtga cgcgccgggg
     3481 gccgggggcc tggagccgta ggtgaacacg gactgtccgt cggccagggg gaacgtctcg
     3541 acctcggcct cggggcccgc tccgccggag agggccccga tccacgcggg tgccgccgag
     3601 gcgatgtcct ccctgaaccc ggagtggcgc tccgggacca gggcgcggac cggaccgccg
     3661 gagggggtgg cgccgtagcg ttcgccggag ggggagagga gttcctccgc ctccaggtag
     3721 gtgtcgttga ccacgagcag gtcgaagccg gggcgggtcc cgcccaacgg caggaccgac
     3781 tcgggcggga cctggtcgga gaggatgagg ccgccgccgg tgtcgacccg ccgcagccag
     3841 gggccgagcc gttcgtccat ggtgccgtgc tcgtcgaggc tgacgctgcc gttgacggtg
     3901 acgagggagg tgtctcccgt tcgcgcgaac agttccaggc cggcctgttg ctcccgtacc
     3961 gtcgccgtgt ggtggacgac cgctccgagg acactgagaa ccaggaggag gacgggaacc
     4021 cgcaccaggt agacggcggt ggtggcggtc cgggccggga ggcgcccctt gagggcgggc
     4081 aggacggcgg tgaggtggac ggcgccgagc gcggcggcgt gggtcgccag ggctgcggcg
     4141 agcaggggga cgagcagggc cgcggtggtg agggcgtagg agtcgaggcg gctccagccg
     4201 ttgtagaggc cgagcacggc cagtacggcc gctgccgcgc tggggagcgc cacggcccac
     4261 aaccgtgcga tccggaccag gtcgcgtatg aggatgcggg tgtaggagcg cccctggagg
     4321 cgctggaccg cgtagtccct ggagtcgagg aggacgccga cggaggccga ggtgaccacc
     4381 acgagcagtg tggcggccag ggtgttggac agtgcgccgc cggtcaggag gaaccactgg
     4441 tcggactcgg tggcgccggg tgcctgggag agcccgtgtt cggccagggc ctcctccagg
     4501 gcctgttcgc tctccggcgg cccgaagagg gtgtagtagc cccgtgggga ggtgccggtg
     4561 tactcctcca gagggtggac gctcagctcc atggtgcgac cgaaggtcgg gaagccgtcg
     4621 gtgagccagt cggccctggg ggagtccggg tcgtccagga cgaggtacat gtgccagagc
     4681 gtgtcgggct cgtccacgtc ggggaaggtg tacccgatcg cggcgccctg ttcggcggcg
     4741 acccgtgtga gggtgggggc gacgtcggcg gcctcggtgc ctcgggggtt ctcggtgatc
     4801 cacacgacgt cggagtgctc tccggcggtg ggcatccgga gttcggagcc ggacaggacg
     4861 agcgcggaga tgagggcggc gagcaggagg agcgcgacgt gggcgaaggc ggtggtccgg
     4921 tggggcatgg tgtccatggt gggggagggg tggcccgccg gcacggcgtt gggccgacgg
     4981 ggccggaacg ggaagagccc tcagcacagg ttccagtagg cttcgttgcc gccccaccag
     5041 cgcgggggcg cgtaggcctg ggcggtgtac ccgggaagcg tcgagggggt ccggtcggtg
     5101 taggtgccga ccgccgtcgc gccgtggcag cgggtggagt ggtggtagat ggagtagacg
     5161 gtggtcttgg tgacaccgtg tgaccaggtg ccgccgccga cgtaggaggt cgcggccgac
     5221 gcgatccccg cggctccgag gccgacgccc gctccgatca acagggtcac ggcggctttc
     5281 ttcagaagtt tcatgtgtcc ccttcgaggt gtccgccttt gtgcgttttt gtcccatggc
     5341 ggagcccgag ggaagaatat acctgcatgt gaattttttc aatggggcag gtgggatatc
     5401 gtccgttgat tgggagggga aagtgtgttc tgtgtcctat atggggagtg ggaatgtcat
     5461 catgcctgat catcgcgcga taagcgtttc ggtcatctca taattagaga agggcatatt
     5521 tcaggggtgg cgaaagtcct tttcccggca cgccggtgga agaaggggcc ggcagcggac
     5581 ggacgaggtc agataccacc ggtgaaacgt cccggcgcga ggcggcggcc cgggtcgaag
     5641 gcgtccttga ccgcgcgcat cagcggcagg cccggcaccg tcccccacag gtcgatcccg
     5701 gcgccgtgta caccgggctc ggcacgcagc accgtcgccg accactccgg cagggcccgc
     5761 acacccgcca ggacctcacc gaccgcggcg gcgccggttc ccggggcgaa ggccgcgtag
     5821 agcgcgccgc tggccgccga cccccggacg cgtacccgcg ccccgaccgc accggccagc
     5881 tcgcacgtcc gcgcggacgc cgccaccgaa gcggccggag gccccgacag gaacaccagc
     5941 gtgccctgct cggcgaccag tccccacccc gccgggagcc gatcggcgac ctcaccgccg
     6001 cccagcgccg ccacggtccc ggcgacgcgc gcggccatcc cctcggccgt cccctccagg
     6061 gccacggtca ggtccgcccg gccctccgcg ggccagtcca gcgccacggc ggagggtacg
     6121 accgtgcgtg cgcgcagtgc ggccgccatc cgctccccgc gcgcggccga ggggaccggc
     6181 gcggtgaccg tcctcagggc gggcgggagg gggtgcgtcc ggaaggtgac cgacgccacc
     6241 agacccaggg tgcccagggc cccggtgtgc agcttcgcca ggtcgtaccc ggccacgttc
     6301 ttgaccaccc ggccgccggt gcgcgccacc accccgtccg cacgcaccac ggtcatcccg
     6361 atcaccaggt cccggagggc gccgtggagg aggcgtcgcg ggccgcacac cccggtggcg
     6421 accatgccgc ccaccgtgcc gcccgtgcgc accgggtcga cggacagtct ctgtccggcc
     6481 ccggccagca cgtccacgag ttcggacacc ggtgtccccg ccccgaccgt caccacgagg
     6541 tcctcggcgg tgtgctcgat ccccctcaga ccggcggtct ccaccagcag gtccgccgag
     6601 cacggcggcg ctccccagtc cagggcggtc cccccgcccc ggaacaccga ggccgcaccg
     6661 tgccggtcgg ccgcggccag gacgcgggcg gcggcagcgg tgtcggcagg acgcaccacc
     6721 agggcgggga cgaccccgcc cacggcgtcc ccggggccgc ccggacggac acgggacccg
     6781 gattcggcca gggccgtgcg cagggagccc tcgacggggg cggggtgatc gggacgcacg
     6841 cggatcctcc ggtcagaact gggtcgcccg gccggactcc accagcgggt gcacgcccct
     6901 gcggaccccc ggccgttcac cgcacaggcg cggcgtgggc aggagcttgt ccgggttggc
     6961 gatgccccgc gggtcgaacg cccgccgaag ccggtcgaag gtgtcgaggt cgtcggggga
     7021 gtacatgcgc ggcatggagc acgccttgtc cgtgcccacc ccgtgctcgc cggtgatcga
     7081 gccgccgtgg gccacgcaca ggtccaggat ggccgcggac acctcctcgg cacggcggtg
     7141 gccgtcgggg tcggtgtcgt cgaacatcac cagcgggtgc aggttgccgt cccccgcgtg
     7201 gaagacgttg gccacgggga taccggtctt cgcggacagg tcggcgatcg cgcgcagcac
     7261 ccgcggcagg gccgtgcgcg ggacgacctc gtcctggacg acgtaggcgg ggctcatcgc
     7321 gccgaccgcg tcgaaggcgg ccttgcgccc cgcccagatc cgggcccgct ccccgccgtc
     7381 ggcggcggtg cgggtggcgc gggcgccgtg ctcggcgcac aggtcccgca cctcggccag
     7441 gtgcgcgtcc acgtccgggg cggggccgtc cagctcgacg atgagcacgg cggcggcatc
     7501 ggtgggatag ccggtgtcca tcagcgcgtt gaccgcctcg acggacaggg cgtccatcat
     7561 ctcgatcgcc gagggcagca gcccggagga gacgatggcg ctcaccgctg cgcccccgga
     7621 gtcgagggag tcgaaggcgg ccagcagggt caccgtcctc tccggcagcc gggtgaggcc
     7681 gacggtgacc cgggtgacga tgccgagcgt gccctcggag ccgacgatcg cgcggatcag
     7741 gtcgtagccg ggagcgtcgg gggccttgcc gcccaggcgg acggtctcgc ctccgggcag
     7801 gaccagttcc agaccgcgca cgtgggtggc ggtgaacccg tacttgaggc agtgcgctcc
     7861 gccggagttc tcggccacgt tgccccccac cgagcagacc gcctggctgg acgggtcggg
     7921 cgcgtagtag tacccgtggg gtgccgcggc ggtggtgacg tcgaggttgg ggacgccggg
     7981 ttcgacgacg gcgcactcgt tgtcggggtc gatctcgatg acgcggcgca ttcgcgcggt
     8041 gctcagcagc acgccctcgc ggtgggggag ggccccgccg ctcaggccgg tcccggcgcc
     8101 ccgggggacg aagggcacgc cgtgttcggc gcacagggcc aggacggcgg acacctgttc
     8161 ggtggtggtc ggcaggacga ccacgccggg cagtgagcgc cggtgggtga tgccgtcgtg
     8221 gtcgaagccg cggcgctcct cgtcgcccgt gaggaccgcg tcgccgccgc aggcctcccg
     8281 cagcaggggg atgagggtgg tcagggcctc ggacatggcg cctccccggg gctcgtcgtc
     8341 tcggccgcct ctggcttgca acgtacgccg gtgcccgcgg cggggcaagg aggtgcgggg
     8401 ccgccccgcg gggcggcccc ggcacccgct agggcatgcg ctcgtaggcg ggcagggtga
     8461 ggaagtcggc gtagtcgtcg gcgagggcga cctcggcgaa cagctcgccg gcctgctggt
     8521 agaggccctc gtcgaaggcc ttgcccaggc cctggcggat gttggccatc tcctcgtcga
     8581 tgatctgctt gacgaggccg gcggtgacct tggggccgtc gtcgagcgtg acgtcgttgt
     8641 gcagccactg ccagatctgg gagcgggaga tctccgcggt ggcggcgtcc tccatcaggt
     8701 tgtggatggc caccgcgccg gtgccgccca tccacgtcgc caggtactgg agggcgacgt
     8761 tgatgttgcc gcgcaggccg gccagggtga cgcccccctc ggtcttgtcc acggccagca
     8821 ggtcggcggc ggagacctcg acgtccgggc gctgcttgtc gatctggttg gggcgctcgc
     8881 ccaggacgcc gtcgaagatc tcccggcaga cggggaccag gtcggggtgg gccacccagg
     8941 agccgtcgaa gccgtcgccg gactcgcggg acttgtcgtc gcggaccttg gcgaaggcgt
     9001 tcttgttgac ctcctcgtcc ttgcgggagg ggatgaaggc ggccatgccg ccgatggcgt
     9061 gggcgccgcg cttgtggcag gtcttgacca gcagctcggt gtaggcgcgc atcatcgggg
     9121 cggtcatggt gacggcgttg cgctcgggca gcaggaagcg tcggccgcgg gtgcggtggg
     9181 tcttgatgat gctgaagagg tagtcccagc gtcccgcgtt gaggccggcg gagtgctcgc
     9241 gcagttcgta gaggatctcc tccatctcga aggcggccgg gatggtctcg atcaggcagg
     9301 tggcgcggat ggtgccgcgc tcgatcccca ggcgctcctg ggcgaggacg aagacgtcgt
     9361 tccacaggcg ggcttcgagg tggctctgca tcttgggcag gtagaagtag gggcccttgc
     9421 ccttggcgag ctggcgctgg gcgcagtgga agaagtacag ggcgaagtcg acgatgccgc
     9481 cgctggtgcg ctggccgtcg accaggatgt gcttctcgtc caggtgccag ccgcgcgggc
     9541 gcacgatcat ggtggcgagt gcggagtcct ccttgagggc gtagctcttg ccctgggggg
     9601 aggtgaagtc gatcgtgcgg tccagggcgt cgcgcaggtt gagctgcccc tggaccatgt
     9661 tctcccacag cggggtgttg gcgtcctcga agtcggccag ccagatcttc gcgccggagt
     9721 tgagcgcgtt gatggtcatc ttgcggtcgg tggggccggt gatctcgacc cggcggtcct
     9781 cgatgcccgg ggcgggtgcg gcgaccttcc agcccgtgtc atcgcggatg tgcttggtct
     9841 cggggaggaa gtcgaggtcc tcgccggccg agatccgctc ctggcgctcc ttgcgggcgg
     9901 ccagcagctc ctggcggcgc tcctcgaagg cgcggtgcag ttcggcgacg agggcgaggg
     9961 cgtcgtcggt gaggatctcg tcgaagcggt cgtgcagcgg gcccgtgatc tcgacccctg
    10021 gcgtggcacc catgtcaaac cttccgcaat acgaaataag cttctattat gtggaaaaga
    10081 tactctcttg ccggggggtg gtcaacgcga atcgcgtggt gagcggtggg gtaaatttcc
    10141 ctcatgtaaa gatttgcgaa tattctcgcg gagtgttttc ccgttcgtga gtatcccatc
    10201 gccgacgggg caagcccggc cccgcgcgcc gggctcgcac cgcccgggat aatgacgtgc
    10261 caggaccgct ccgaggtggg accatcgatc catc
//
