LOCUS       NZ_AZUV01000015        22170 bp    DNA     linear   CON 04-JUN-2024
DEFINITION  Mesorhizobium sp. WSM1293 MesloDRAFT_scaffold_12.13_C, whole genome
            shotgun sequence.
ACCESSION   NZ_AZUV01000015
VERSION     NZ_AZUV01000015.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Mesorhizobium sp. WSM1293
  ORGANISM  Mesorhizobium sp. WSM1293
            Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
            Phyllobacteriaceae; Mesorhizobium.
REFERENCE   1  (bases 1 to 165998)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (19-DEC-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            assembly                          :: ALLPATHS v. R37654
            country                           :: Greece
            environment :: Host; Plant root; Root nodule; Soil
            investigation_type                :: bacteria_archaea
            lat_lon                           :: 37.147182 24.514618
            project_name                      :: Mesorhizobium loti WSM1293
            sequencing_meth                   :: WGS
            biotic_relationship               :: Symbiotic
            rel_to_oxygen                     :: Aerobe
            finishing_strategy                :: Level 1: Standard Draft
            GOLD Stamp ID                     :: Gi08882
            Current Finishing Status          :: Level 1: Standard Draft
            Type Strain                       :: No
            Funding Program                   :: DOE-DD 2010
            Isolation Site :: Serifos, towards Hora from beach
            Host Name                         :: Lotus sp.
            Cell Shape                        :: Rod-shaped
            Motility                          :: Motile
            Sporulation                       :: Nonsporulating
            Temperature Range                 :: Mesophile
            Temperature Optimum               :: 28
            pH                                :: 5-8
            Gram Staining                     :: Gram-
            Symbiotic Relationship            :: Mutualistic
            Diseases                          :: None
            Phenotypes                        :: Non-Pathogen
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method                   :: ALLPATHS v. R37654
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: 454-GS-FLX-Titanium; Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000513875.1-RS_2024_06_04
            Annotation Date                   :: 06/04/2024 01:41:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,732
            CDSs (total)                      :: 6,668
            Genes (coding)                    :: 6,524
            CDSs (with protein)               :: 6,524
            Genes (RNA)                       :: 64
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 54
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 144
            CDSs (without protein)            :: 144
            Pseudo Genes (ambiguous residues) :: 0 of 144
            Pseudo Genes (frameshifted)       :: 76 of 144
            Pseudo Genes (incomplete)         :: 111 of 144
            Pseudo Genes (internal stop)      :: 9 of 144
            Pseudo Genes (multiple problems)  :: 45 of 144
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:13:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 116687
            Orig. end                         :: 138857
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AZUV01000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..22170
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="1"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22170
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22170
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12170](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12170
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    283..298
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.47"
                     /tool="antismash"
     misc_feature    426..439
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.95"
                     /tool="antismash"
     misc_feature    complement(704..719)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.65"
                     /tool="antismash"
     gene            751..1491
                     /locus_tag="M729_RS0120005"
     CDS             751..1491
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014766066.1"
                     /locus_tag="M729_RS0120005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_013532066.1"
                     /transl_table=11
                     /translation="MQPVGAVVPLKVDIAEKTFRSARGVSITALQDLSFEVRQGEFACL
                     LGPSGCGKTTTLRILLGLDKDFSGSFQLPQGGSNRIAAVFQEPTLLPWRTVEQNVRLAL
                     PKSLRAKNLDGLFDTLGLAAMRSLYPAELSLGLARRAALARAFATEPAVLFLDEPFVSL
                     DEQTAERLRHLLLTVWSARPTTALMVTHNLREALMLSDRIIVLAPRPTHVLGVFDVRLP
                     RQHRNSQVMSDLLRSFHHRFPDVT"
     gene            1526..2488
                     /locus_tag="M729_RS0120010"
     CDS             1526..2488
                     /codon_start=1
                     /gene_functions="resistance (resist) SubclassB1"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532067.1"
                     /locus_tag="M729_RS0120010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="quinoprotein relay system zinc metallohydrolase
                     2"
                     /protein_id="WP_027162621.1"
                     /transl_table=11
                     /translation="MSIDRLRRRLVSGFACTAASAALMPCCLGRAAAGNLGFSLRQIAD
                     GVFAFQGTDELMTAANDGAICNLGAVIGTDAVAVIDSGGSLIEAHAFLAAIGKVTAKPV
                     RFLVNTHMHPDHIFGNAAFREIGATIVGHRNLPRALDARGAFYLHNYREQLGEALMEGV
                     EIVSPTRLVDDHLQLDLGGRTIELRAWKAAHTDNDLTVFDTTTRTLFAGDLVFMGSLPT
                     LDGSLLGWLRQMDALTAIDAARVVPGHGPVTADWPQALAGERRYFEVLARDIRKAIADG
                     TPLREAVKTAGGSERDNWHLFDDYNERNATAAFAELEWE"
     gene            2607..3458
                     /locus_tag="M729_RS0120015"
     CDS             2607..3458
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532068.1"
                     /locus_tag="M729_RS0120015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="quinoprotein dehydrogenase-associated SoxYZ-like
                     carrier"
                     /protein_id="WP_032808934.1"
                     /transl_table=11
                     /translation="MQNQAYSSRQLASVFAAIILTIGTLLGSSGAANAQQTTASSDRIW
                     HDLKGDVFGDRAILVDTGVVRIEAPKRAQDAAIVPVDIYLDPAKAPDGIKSVTLIIDAN
                     PAPVAATFQLGKDAGVTHLSTRVRVNDYSYLRAIAETQGGQLHMVQTFVKASGGCSAPA
                     VKNQDEANATMGQMKLRQFPPKETMTKTEELQLMIRHPNNSGLQRDPLTQYFIPAHFVQ
                     KLSISQAGRPILSMEGGISISEDPNFRFDFTVHGNGEIQVEAIDTDGKTFRNQWPLETA
                     GL"
     gene            complement(3583..3936)
                     /locus_tag="M729_RS0120020"
     CDS             complement(3583..3936)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008836353.1"
                     /locus_tag="M729_RS0120020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_013532069.1"
                     /transl_table=11
                     /translation="MIRYVGFSTLPLLLAAPLAFANPAGAAGDYPTATIADYVLGCMQT
                     NGQTRQALESCSCSIDVIASILPYDHYERAETFKSMSLTTGESAALFRESAPAKAARTE
                     LKRAQSEADVRCF"
     misc_feature    complement(4165..4178)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.85"
                     /tool="antismash"
     misc_feature    4208..4228
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.42"
                     /tool="antismash"
     misc_feature    complement(4235..4244)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    complement(4289..4302)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.44"
                     /tool="antismash"
     gene            4623..6524
                     /locus_tag="M729_RS0120025"
     CDS             4623..6524
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014766064.1"
                     /locus_tag="M729_RS0120025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methanol/ethanol family PQQ-dependent
                     dehydrogenase"
                     /protein_id="WP_013532070.1"
                     /transl_table=11
                     /translation="MRVLTKATYILTTAAFLSLGAAYTASANEDLAKLASDSKNWAMQT
                     GDYANTRYSKLNQITADNVKNLQVKWTFSTGVLRGHEGGPLIIGDVMYVHTPFPNNVFA
                     LDLKNDGKILWKYEPKQDPNVIPIMCCDTVNRGVAYGDGKIILNQADTTVVALDAKTGK
                     VVWSVKNGDQTDGGKGESGTAAPVVVKDKVLIGVSGAEFGVRGWLAAYNLKDGKLAWKA
                     YSEGPDADTLIDPEKTTQLGKPVGKDSGTNTWEGEQWKTGGGTTWGWYSYDPKLNLVYY
                     GTGNPSTWNPVQRPGDNRWSMTIMARDADTGVAKWLYQMTPHDEWDYDGINEMILVDGM
                     EVNGAKHDVLVHFDRNGFAYTMDRATGDLLVAKKYDPAVNWATEVVMDPKSEQYGRPQV
                     VAKYSTQQNGEDTNSTGICPAALGTKDQQPAAYSPKTGLFYVPTNHVCMDYEPYKVSYT
                     AGQPYVGATVSMYPAPGGDGNMGNFIAWDAAKGEIVWSKPEQFSVWSGALATDGDVVFY
                     GTLEGYIKAVDKDGKELYKFKTPSGIIGNITTYEQGGKQYIAVLSGVGGWAGIGLAGGL
                     LSPDNAAAWHGAVDQGRAQGDQAAVVGTAGLGAVGGYAALADYTTLGGQLTVFGLPD"
     misc_feature    6699..6714
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.06"
                     /tool="antismash"
     gene            6703..7227
                     /locus_tag="M729_RS0120030"
     CDS             6703..7227
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008836355.1"
                     /locus_tag="M729_RS0120030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="c-type cytochrome, methanol metabolism-related"
                     /protein_id="WP_013532071.1"
                     /transl_table=11
                     /translation="MSVRIVISAFVLALLPLASSSLARADDSMEKAKAVKEEGGKYLDA
                     DGNPTYKIENGTVDWYTFSGYRRYHSDCHVCHGQDATGSSYAPALVNSLKTMDYATFLS
                     IVAEGRKNVGGGKENVMPAFGDNKNVYCYLDDLYVYLRARADGAAPRGRPPKHEDKAQA
                     AKDAEASCMGG"
     gene            7199..8092
                     /locus_tag="M729_RS0120035"
     CDS             7199..8092
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008836356.1"
                     /locus_tag="M729_RS0120035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="quinoprotein dehydrogenase-associated putative
                     ABC transporter substrate-binding protein"
                     /protein_id="WP_013532072.1"
                     /transl_table=11
                     /translation="MPKHPAWVDDMIGRDALKLRVVLPILGTLALLPSNAHAQSAGLGA
                     AGELVDPDILRVCADPSNMPFTDKSGEGFENKLAELVAAKTGRKSVSYTWFPTITGFVR
                     NTLGANRCDIIMGYAQGDELVQNTNAYYRSAYVLVHPKSHDMEGVETIEDPRLTGKTIG
                     VVESTPPTANMAANKLLRTAKIYPLAVDTRVTPSMGEVMIKDMLAHKIDAAVLWGPMAG
                     YYAKELGADVTIVPLVKEKTGSRMSYRITMGVRPSDQEWKRTLNRVIRENQAEITRILL
                     SYNVPLIDEHDNLITQ"
     gene            8089..8649
                     /locus_tag="M729_RS0120040"
     CDS             8089..8649
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532073.1"
                     /locus_tag="M729_RS0120040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent catabolism-associated CXXCW motif
                     protein"
                     /protein_id="WP_027162625.1"
                     /transl_table=11
                     /translation="MNGRETIFVLVAASLLGLAEPTWAGDIAEPSGFRMDDYRAPVPRT
                     LQGARVVTTVEAEALWRAKKAIFFDVMPDTPKPANLPAGTIWRDKVRKDIPGSIWLANV
                     GYGAISQETASYFRQGLAAKAGTDKSRTVLFYCMTNCWMSWNAAKRAVQWGYSSVIWYP
                     LGADGWEDANLPLEEKKPYATNN"
     gene            9066..10004
                     /gene="pqqB"
                     /locus_tag="M729_RS0120050"
     CDS             9066..10004
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532075.1"
                     /locus_tag="M729_RS0120050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_027162626.1"
                     /transl_table=11
                     /translation="MHLRIIGSAAGGGFPQWNCNYRLSRAARNGMASVHPRTQSSVAAS
                     ADGLGWVLFNASPDIRQQIAATPELQPAGDAPLRSTPIRAVVLTNADVDHIAGLLSLRE
                     RQPFAIYATAQVLATLEANSIFNVLDPALVPRRILPPAKELAICDAEGRDTGVMIEPFP
                     VPGKIALYLEDRDHPDANFSSDAGDTIGVRIAGIGSRGSVFYIPGCARIDARLRARLTD
                     AACLLFDGTVYTDDEMIVAGVGQKTGARMGHLAISGELGSIAGLANVKVGRRVFVHINN
                     TNPILDESSAEHAAVKAAGWEIANDGMEMEF"
     gene            10001..10759
                     /gene="pqqC"
                     /locus_tag="M729_RS0120055"
     CDS             10001..10759
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532076.1"
                     /locus_tag="M729_RS0120055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_024504367.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.7e-100, bitscore:
                     328.1, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDFRDAAKGGLSTSALEAVLRQVGAERYHNRHPFHHRMTSGALS
                     KAEMKAWALNRYCYQAVIPRKDAMILVHAEDPAFRAAWRKRIEDHDGEDGWSGGIARWL
                     HLATSLGLDAEAVKSERLALPATRFAVGAYLSFCTNRTLFEAVASSLTEMFSPLIIGER
                     VPAMLAKYDYITEDTLAYFKQRPEQASRDADFALDYVLSHADTAERQQQAIDALVFKCD
                     ILWAMLDALQHAYGERGNIPPGAFQPEAAL"
     gene            10759..11052
                     /gene="pqqD"
                     /locus_tag="M729_RS0120060"
     CDS             10759..11052
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Thurincin_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015316539.1"
                     /locus_tag="M729_RS0120060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_032808964.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.5e-26, bitscore:
                     85.5, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.9e-15, bitscore: 49.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Thurincin_rSAM_RRE (E-value: 2.9e-08,
                     bitscore: 27.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9.8e-08,
                     bitscore: 25.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRERAVVSLRSVPSLPKHVRIQYDPLRQAFAVLSPEKIFWPND
                     VSLDILRRCDGRSTVGDIIAGLAADYEAEQEAVATDVIAFLQEWSDKLLVRL"
     aSDomain        10780..11046
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M729_RS0120060_PqqD_RRE.1"
                     /evalue="2.50E-27"
                     /identifier="RREFam006.1"
                     /label="M729_RS0120060"
                     /locus_tag="M729_RS0120060"
                     /protein_end="96"
                     /protein_start="7"
                     /score="85.5"
                     /tool="antismash"
                     /translation="VVSLRSVPSLPKHVRIQYDPLRQAFAVLSPEKIFWPNDVSLDILR
                     RCDGRSTVGDIIAGLAADYEAEQEAVATDVIAFLQEWSDKLLVR"
     aSDomain        10861..11028
                     /aSDomain="Thurincin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a thurincin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M729_RS0120060_Thurincin_rSAM_RRE.1"
                     /evalue="4.60E-09"
                     /identifier="RREFam019.1"
                     /label="M729_RS0120060"
                     /locus_tag="M729_RS0120060"
                     /protein_end="90"
                     /protein_start="34"
                     /score="27.2"
                     /tool="antismash"
                     /translation="LSPEKIFWPNDVSLDILRRCDGRSTVGDIIAGLAADYEAEQEAVA
                     TDVIAFLQEWS"
     aSDomain        10888..11046
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M729_RS0120060_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="1.60E-08"
                     /identifier="RREFam002.1"
                     /label="M729_RS0120060"
                     /locus_tag="M729_RS0120060"
                     /protein_end="96"
                     /protein_start="43"
                     /score="25.5"
                     /tool="antismash"
                     /translation="NDVSLDILRRCDGRSTVGDIIAGLAADYEAEQEAVATDVIAFLQE
                     WSDKLLVR"
     gene            11049..12170
                     /gene="pqqE"
                     /locus_tag="M729_RS0120065"
     CDS             11049..12170
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532078.1"
                     /locus_tag="M729_RS0120065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_027162627.1"
                     /sec_met_domain="PF04055 (E-value: 4.3e-25, bitscore: 82.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.3e-06, bitscore: 22.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.4e-11, bitscore:
                     36.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 7.8e-10, bitscore: 32.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPLLPPIGMLAELTHRCPLQCPYCSNPLELLKANRELDTETWL
                     ALFSEAADLGVLQVHLSGGEPTLRRDLEQLIAGLAGRGVYTNLITAGVGIVEGRVEAFA
                     EAGLDHLQLSFQGARPATTDRIGNHKGAHEKKLETARRARAAGLPLTVNAPIHRHNIEE
                     VPEFIDLALSLGAERLEIANVQYAGWALTNRDQLMPEREAVDRQAEIVAEAQERLAGII
                     NIDFVTPDYFAIYPKPCMGGWARDAFMVTPDGTVLPCHAAQTIPSLSFERFEPHRLSSI
                     WADSPAFNAFRGTDWMQEPCRGCERREIDWGGCRCQAMAIAGDAAATDPACAKSPIHAR
                     MAMLIDEARRIATVPSREEAFVYRRIGAVTESA"
     gene            complement(12190..12768)
                     /locus_tag="M729_RS01000000135470"
     CDS             complement(12190..12768)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M729_RS01000000135470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_245267601.1"
                     /transl_table=11
                     /translation="MHPRRYQPWRTSRRRRARPSTNAPGKNCLTKLSGWPPGRSAAISA
                     FRQIHFEFAGKALAIKYSDGGAADPLVEVFDIKPGETAEAALQRLFLEKTDKAVSARCV
                     LAPYTEGTVPAGVKRYTFSPDAAYAKELKALASSDEIPEPPCGDWGEMPDGMQYFEVPA
                     GEGHSLLFVRIGQDEPLFDEQTLRVLPRG"
     gene            complement(12801..13322)
                     /locus_tag="M729_RS0120075"
     CDS             complement(12801..13322)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013895813.1"
                     /locus_tag="M729_RS0120075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_027162628.1"
                     /transl_table=11
                     /translation="MITRILAFFLLGLLGPMQAALAKECLLSHATYQEPRSGAVVQFRP
                     LANEPAALTAEVFSLAVPKTGTSLPADITWTNGKNSFPLGTIRHACTDDDREGGLQDGS
                     GLCRLWEGQVYALTGGGAEQLNSREATPAPRGLLLPGFGVAFTEGADFANANPGGSAWD
                     AFILTGCSDE"
     gene            13487..13846
                     /locus_tag="M729_RS0120080"
     CDS             13487..13846
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532081.1"
                     /locus_tag="M729_RS0120080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_027162629.1"
                     /transl_table=11
                     /translation="MRRLVMTTAISAFAGGSALAAPPYVGTWSTDRLNCHAAPDIQRET
                     VFTVDQASLSFPDLGCEQATFRKSSTGWVVHASQCYGSDPSIEEPFARVIHIVRHGATL
                     RFTWPGFNSGPLVRC"
     gene            complement(13861..14826)
                     /locus_tag="M729_RS0120085"
     CDS             complement(13861..14826)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013895816.1"
                     /locus_tag="M729_RS0120085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3592 domain-containing protein"
                     /protein_id="WP_245267602.1"
                     /transl_table=11
                     /translation="MELKIMLVGFACVVAGALSFITFMKWREVKALSRWLPTPGKIISS
                     RVEAREVRSSGVGSDSTDTTEMRNFPAITFEYKVGGKKFQSSRYSVKENLGNFEVTETL
                     AQFPRGAEVTVFYNPADPSKAVIKRTMPEGAFKFMIQLSAGLVVGALVLVFSVGGVLEA
                     IRPHLPKPQNLGAAALLLFMGLFALRMGFVQKSMAEQAAKWPVTAGRIDASGLQALRNH
                     SGYGRWRTVFKSRIVYSYDVAGQRYSADRVTFGGTVTASLPGLVGGQARQYVEGSKVDV
                     HYDPANPGSAVLECRVRGLWLLWICSAGFLGGAAFLVGLV"
     gene            complement(14945..15553)
                     /locus_tag="M729_RS0120090"
     CDS             complement(14945..15553)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010909151.1"
                     /locus_tag="M729_RS0120090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_013532083.1"
                     /transl_table=11
                     /translation="MGVSSEALAQSRQTISAYEDYAEQYDAIVRHVPNEREQASLKRLV
                     AIAGTGGRILEVGSGAGYDADFLENLGVKVRRTDATKRFLELQAARGKHGELLDLITDD
                     LGGPYDAVLALCVLIHVPRDQTDQVLAKIAGSLRPGGAFLVSMRNGDGETSGEYHMVYW
                     RRDDFAARLEGAGLVLIRDDFNVGRNSEEWNTFLAVKPA"
     gene            complement(15779..16876)
                     /locus_tag="M729_RS0120100"
     CDS             complement(15779..16876)
                     /GO_function="GO:0003796 - lysozyme activity [Evidence
                     IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0016998 - cell wall macromolecule catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532084.1"
                     /locus_tag="M729_RS0120100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GH25 family lysozyme"
                     /protein_id="WP_027162631.1"
                     /transl_table=11
                     /translation="MRIPGVVSFLIASLCLAGCSSTAGVDALDLQKPSNETTSSVIRPP
                     APIAAAPAARGNRAARAGLAPMSDNGPGEKTRPFGLAEEEETGVFAAPDAPDPQVPDVG
                     GLPVEPAALVSPPKLLTRAAPAMLAGPLTRYGFRDAKPINFGKGSPRRLAVHGVDVSRW
                     QGNVNWDKLRAQGANFAYIKATDGGDHLDPMFMKNWRNADAAGLKRGAYHFFYWCRTAG
                     EQADWFIRNVPRVEGALPPVIDVEWNGESSCKRRPSREKVLEKMQVFMDKLERYYGQRP
                     IIYTAPDFYRDNLRGEFLDYPFWLRAVAQHPSKVYPGRKWLFWQYSGSGLSHGVTGRID
                     LNVFHGDERQWRAWAGGRQTVADAN"
     misc_feature    complement(16846..16855)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.44"
                     /tool="antismash"
     misc_feature    16975..16990
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.56"
                     /tool="antismash"
     misc_feature    16992..17007
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.72"
                     /tool="antismash"
     misc_feature    complement(16992..17008)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     gene            complement(17026..17814)
                     /locus_tag="M729_RS0120105"
     CDS             complement(17026..17814)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019857827.1"
                     /locus_tag="M729_RS0120105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_013532085.1"
                     /transl_table=11
                     /translation="MDFLTLLQSVPLLLAMAKGALPSVAALGASFGQWVVSLPPCRDFT
                     FEATSYLVCEVDPKRYQLELFWKDAAGKPFQSLHNLHAAQQAIGRTMLFGINAGMYHPN
                     LAPVGLYVERGQEMASVKTGSGSGNFSLQPNGIFYIRDGRAAVRATRDFVKRRPTVDYA
                     TQSGPMLVIDGKLHPKFQADGTSRKTRDGVGVRKDGVAVFAISNGTVTFHAFARLFRDA
                     LGCDNALFLDGTISSLFAPAIGRKDDYWNLGPMIGVFRKS"
     gene            complement(17885..18757)
                     /locus_tag="M729_RS0120110"
     CDS             complement(17885..18757)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0050380 - undecaprenyl-diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0016311 - dephosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532086.1"
                     /locus_tag="M729_RS0120110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="undecaprenyl-diphosphate phosphatase"
                     /protein_id="WP_013532086.1"
                     /transl_table=11
                     /translation="MADICTQGLDTGFVGLGFAKVAFLGVVQGITELLPISSTAHMRIV
                     PAVLGWQDPGSAFSAAMQLAALAAVVSYFWSDVRDILFGSLDALARRDFADRHFKLALW
                     IVLATIPIVIAGVALSGLLNACNSPLRSLTVIGWACIAMAILLALAEIFARHRRSMGDA
                     SLTDALLVGIAQIGALVPGVSRSGSTLTAALGLGFKRAEAARFSFLLGLPAIALAGLKE
                     LWELHKVHLDAHGWSVLAVGLVVASISAFFAIWGLMRVLERFSAWPFVIYRGLLGIVLL
                     SSVAMGWLV"
     gene            complement(18947..19144)
                     /locus_tag="M729_RS0120115"
     CDS             complement(18947..19144)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013895824.1"
                     /locus_tag="M729_RS0120115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_027162632.1"
                     /transl_table=11
                     /translation="MNDSISTLDELLRDPMVLLVMERDRVRPEQVRMLLERARRPSTDE
                     PEVPPAHVIARTCQKLWLCP"
     gene            complement(19330..19728)
                     /locus_tag="M729_RS0120120"
     CDS             complement(19330..19728)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010909137.1"
                     /locus_tag="M729_RS0120120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GFA family protein"
                     /protein_id="WP_013532088.1"
                     /transl_table=11
                     /translation="MARYEGGCLCKAVRYRADAAPINERVCHCRLCQKAIGAAFNARVL
                     FRIEDVTIDGPLATIGSSPDLKRGFCPSCGTTLFSRRDSAGIIGITTGSLDDPTVFKPQ
                     MHIFTASKQPWLVLDDGLPKYEGAPPPG"
     misc_feature    19806..19816
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(19916..20872)
                     /locus_tag="M729_RS0120130"
     CDS             complement(19916..20872)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (64-179). E-value:
                     1.3e-26. Score: 85.6. Matches aSDomain:
                     nrpspksdomains_M729_RS0120130_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013532089.1"
                     /locus_tag="M729_RS0120130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_027162633.1"
                     /sec_met_domain="PF00561 (E-value: 1.2e-22, bitscore: 74.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 8.9e-09, bitscore:
                     29.3, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.3e-18, bitscore:
                     59.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKTLFFAIFASAAALLACPGITNAEETKPAMTTETNALPKPEKS
                     GLLTINGLNYYYAIYGKGEPLLLLHGGLGTTDMFAPILPKLAENRTVIGVDLQGHGRTA
                     LGDRPFTVEAMGDDMAAIVKALGYSQVDVMGYSLGGGVAFRMAVQHPEAVHRLVLVSTG
                     YATDGFYDEMRPQQAQVSAAAAEFMKDTPMYKSYVAVAPHPEEFPKLLDALGGFMRQNR
                     DYSADVAKLKMPVMLVYGDSDMYKPEHEIKFYQMLGGGLKDAGWMRENLSQNRLVILPN
                     RTHYDVFFAPELTAAALPFLNGQTKVKTWDEVVGEME"
     aSDomain        complement(20336..20680)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M729_RS0120130_Abhydrolase_1.1"
                     /evalue="1.30E-26"
                     /label="M729_RS0120130_Abhydrolase_1.1"
                     /locus_tag="M729_RS0120130"
                     /protein_end="179"
                     /protein_start="64"
                     /score="85.6"
                     /tool="antismash"
                     /translation="PLLLLHGGLGTTDMFAPILPKLAENRTVIGVDLQGHGRTALGDRP
                     FTVEAMGDDMAAIVKALGYSQVDVMGYSLGGGVAFRMAVQHPEAVHRLVLVSTGYATDG
                     FYDEMRPQQAQ"
     CDS_motif       complement(20426..20476)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M729_RS0120130_0001"
                     /evalue="5.80E-06"
                     /label="NRPS-te1"
                     /locus_tag="M729_RS0120130"
                     /protein_end="149"
                     /protein_start="132"
                     /score="18.8"
                     /tool="antismash"
                     /translation="VMGYSLGGGVAFRMAVQ"
     gene            complement(20913..21398)
                     /locus_tag="M729_RS0120135"
     CDS             complement(20913..21398)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013895828.1"
                     /locus_tag="M729_RS0120135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SRPBCC family protein"
                     /protein_id="WP_024504356.1"
                     /transl_table=11
                     /translation="MTTKLDIAPTNDRELVLARIIDAPRENVYRCWTDPKLITRWFSPK
                     PWTTPRAEMDVRAGGSSLVVMASPDGNEFPNPGVFLEVVAGRKIVLTDAYTEAWQPSEK
                     PFMTVALTFEDEGNGKTRYIARVRHWSVADREQHEKMGFHEGWGQCADQLEELAKTL"
     gene            complement(21598..21846)
                     /locus_tag="M729_RS0120140"
     CDS             complement(21598..21846)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008875526.1"
                     /locus_tag="M729_RS0120140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ParB N-terminal domain-containing protein"
                     /protein_id="WP_013532091.1"
                     /transl_table=11
                     /translation="MLRVQKVKVDEIYVPTARKKTLHPETVRHLAEDILENGMKTPIQV
                     RHDGKRHILVEGLHRLEAAKWLGETEIEAYLVQAKRH"
ORIGIN
        1 gcatgtccgg ccgacgcagc ctggcgacgg cactggcgcc cgcgctgacg gtagcggttt
       61 ccctgctcgg gctttgcctg ctgtggaacc ttgcggcagg cgtctggcca agccgtgcct
      121 ttccaggacc tgggcaggtc tggcaggtgc ttctcaggga ggctgcgagc ggcgacctct
      181 tttaccatct cggcgtgacc ctcggccggg tcgccgcggc gtatatcgtc gcaatgatca
      241 tcggatccgt catcggcgtt ttgctcggca gctatcgtcg cgtcgaccgt tttttcaacc
      301 cgtgggtgat cctgttcctc aacatcccgg cgctggtggt catcgtcctc ggctacatct
      361 ggttcggcct caacgaggcg gcggcgatcg gcgcggtggc ggtgaacaag atcccgaatg
      421 tcgtggtgac gatgcgtgaa ggcgccagga cgcttgaccc aagctacgcc gaaatggcca
      481 ccgtctatcg cttcggccgc cttgatcgca tccgccatat cctgctgccg caactgcagc
      541 cctatcttgc cgccgcgtcg cgatccggca tcgccctcat ctggaagatc gtcctggtcg
      601 tcgaactgct cggccgctcg aacggtgtcg gcttccagat ccatctctat ttccagcttt
      661 tcgatgtcgc cgccattctt gcctacacgc tggctttcgt ggcggtgatg cttgtcattg
      721 aacttctcct ggtgcagccc gttgaacgac atgcaacccg ttggcgccgt cgtcccgctt
      781 aaggtcgaca tcgccgaaaa gaccttcagg tccgcgcgag gcgtctcgat cacggcgctt
      841 caggaccttt ccttcgaggt ccggcaaggc gaattcgcct gcttgcttgg accgtcgggc
      901 tgcggcaaga ccacgacgct gcgtatcctg cttggcttgg acaaagactt ttccggctcc
      961 ttccagttgc cgcaaggagg ttcgaaccgc atcgccgccg tattccagga accgaccctg
     1021 ctgccgtggc gaacggtgga gcagaatgtc aggctggcgt tgccgaaaag cttgagggcg
     1081 aaaaatctcg acgggctgtt cgacacgctc ggcctcgcgg ccatgcgctc gctctatcct
     1141 gccgaactgt cgctcggcct tgcgcgcagg gcagcacttg ccagggcttt cgccacggag
     1201 ccggcggtgc ttttcctgga cgaacccttt gtctcgctcg acgaacagac cgccgagcgg
     1261 cttcggcatc tgcttttgac cgtgtggtcg gcacggccca cgaccgcctt gatggtgacc
     1321 cacaatctac gcgaggcact gatgctctcg gaccgcatca tcgtgctcgc gccgcggcca
     1381 acccatgtgc tcggcgtgtt cgacgtacgg ttgccacggc aacatcgcaa ttcgcaggtg
     1441 atgagcgacc ttctgcggtc gttccatcat agatttccgg acgtcacctg atcgcctgca
     1501 ggtgaaatgc atatcggagg ccttcatgtc gatcgatcgg ctaagacgca ggcttgtgag
     1561 tggcttcgcc tgtaccgccg ccagcgccgc cttgatgccg tgctgcctcg gacgagccgc
     1621 ggctggcaac ctgggattct cgctcaggca gatcgccgac ggcgtcttcg ccttccaggg
     1681 cacggatgaa ttgatgaccg ccgccaacga cggtgcgatc tgcaatctgg gcgccgtcat
     1741 cggtaccgat gcggttgccg tcatcgacag cggtggcagc ctgatcgagg cgcacgcctt
     1801 tctcgccgcg atcggaaagg taaccgcaaa gccggttcgc ttcctggtca acacccacat
     1861 gcaccccgac cacatcttcg gcaatgcggc attccgggag atcggcgcga ccatcgtcgg
     1921 tcaccgcaat ctgccgcgcg ccctcgacgc gcgtggcgcg ttctatctgc acaactatcg
     1981 cgaacagctt ggcgaggcgc tgatggaggg ggtcgagatc gtgtcgccga ccaggctggt
     2041 cgacgatcac ctgcaactcg acctcggcgg gcgcacgatc gaactgcggg catggaaggc
     2101 ggcgcacacc gacaacgacc tgaccgtatt cgataccacg accagaacgc tctttgccgg
     2161 cgatctggtg ttcatgggct ccttgccgac gctcgacgga tcactgcttg gatggctccg
     2221 ccagatggat gcactcaccg cgatcgacgc cgcgcgcgtc gttccaggtc atggtcctgt
     2281 aacggccgac tggccacagg cactggcggg ggagcgacgc tatttcgagg ttctggcgcg
     2341 cgatatccgc aaggcgatcg ccgacggaac gccgctgcgc gaagcagtca aaaccgcagg
     2401 cggaagcgaa cgggacaatt ggcacctgtt cgacgattac aacgagcgca acgcaacggc
     2461 cgcatttgcc gaactcgaat gggaatagac gacgccgaca tgcgctaggc ggccgcaaag
     2521 cacggcgatt tgccaaggcg tcgccaaagg cttatcctca acgccagcct gggcaccacc
     2581 tctcttgcat tggtggaggc atcgaaatgc aaaatcaagc ttactcgagc cggcagctcg
     2641 catccgtttt cgccgcgatc atcttgacca tcggcacgtt gctcggctcc tcgggagccg
     2701 ccaacgcaca gcaaacaacc gcgtcctcgg atagaatctg gcatgacttg aagggcgacg
     2761 tgttcggcga tcgggcaatt ctggtcgata ccggcgtcgt caggatcgaa gcaccgaagc
     2821 gggcgcagga tgccgccatc gtgcccgtcg atatctatct cgatccagcc aaggcgccag
     2881 acggcatcaa atccgttacc ttgatcatcg atgcgaaccc tgcaccggtg gcggcaacgt
     2941 tccagctcgg caaggatgcc ggcgtgacgc atctgtcgac gcgcgtgcgc gtcaacgact
     3001 attcctatct gcgcgccatc gctgagacgc agggtggtca actccatatg gtacagacct
     3061 tcgtcaaggc gtcaggtggc tgctccgccc ctgcggtcaa gaaccaggac gaggccaacg
     3121 cgacaatggg tcagatgaag ctgcgccagt tcccgcccaa agagacgatg accaagaccg
     3181 aggaactgca gttgatgatc cggcacccta acaattcggg gctgcagcgg gatccgctga
     3241 cccaatattt cataccggcg cattttgtcc agaaactgtc gatctcccaa gccggccggc
     3301 cgatcctctc catggaaggt ggaatatcga tttcggaaga ccccaacttc cgattcgatt
     3361 tcaccgtgca cggcaatggc gaaatccagg ttgaagcgat cgatacggac ggcaaaacat
     3421 ttcgcaatca gtggccgctc gagacagcgg gactctgaag tctcgatatc ttgcgctgga
     3481 ctgccgggtg cttgccactt gatcccgaaa atggagctcg ttcgggaaga tcacgcccag
     3541 gcagaggacg gagctccatc cggcttccgg atggagcagg ctctaaaagc agcgcacgtc
     3601 ggcttccgac tgcgcgcgct tcaattcggt acgggctgcc ttcgccggtg cgctttcgcg
     3661 aaacagcgcc gcgctttcgc ctgtggtcaa agacatgctc ttgaaagtct cggctctctc
     3721 atagtggtcg tagggaagga tcgaggcgat gacgtcgatc gagcaggaac agctttccag
     3781 cgcctgacgt gtctggccgt tcgtctgcat gcagccgagc acgtagtcgg cgatcgttgc
     3841 tgtcgggtaa tcacccgcgg cgcccgcggg gtttgcgaag gccagcggcg cggcaaggag
     3901 cagcggcaaa gtcgaaaatc caacatatct gatcacggga aaacctccgg ttagcctagg
     3961 cgcgatgcgc ccagtcggga tcaccgtggc agttggcaac gtgcagcaga gtcagtcaag
     4021 cgcccatggc ttccgtatgc gaccaaagga ggaatgcggg gcttgtcgac cgtggttccg
     4081 catggcggct ccgtggcctg ctccacgccc cgactccaac gatcatctca tgcttggccc
     4141 actatcgatt cccaatggag cacgcgcatg accatgccga gacatcgaag cgaatacctc
     4201 caaataaaat caacgcttag gcgaaatgta aaaatcaaaa aataactaaa ttttatgtgc
     4261 cccatcgtta tttcgcggtc ataaatactt tatctaacaa ataccgtcct gcttattttc
     4321 ttatattgca ccgcatcatt tatgatattg cggtgcaaaa acaccagcag gcttttttgc
     4381 ttgcctagcc ttttacgatg acatagcctc accctgtttc cggcttcaag ggcgtcaccg
     4441 tcattaggga gcggcgacag tctttcgtag gccaaggtga ggtgggcagt aacggtgccc
     4501 tctgcacatc tggcttaggt cgtgacacgc tgccggaaat atttcccccc cgtgaatcgc
     4561 ttgggcaagc ccttgtgggc tcagcaaatg attcatcact atgaacctcg ggaggaattc
     4621 ggatgcgtgt acttacgaaa gctacctata ttctaaccac tgcggcgttt ctgtcgctcg
     4681 gcgcggccta tacggcgtcg gctaatgagg accttgcaaa gctggcttcg gattcgaaga
     4741 actgggcaat gcagacgggt gactacgcca acacccgcta ttccaaactc aaccagatta
     4801 ctgcggacaa tgtgaagaac ctgcaggtca agtggacctt ttccaccggc gtgctacgag
     4861 gccacgaggg tggaccgctt atcatcggcg atgtgatgta tgtccacacg cctttcccga
     4921 acaatgtctt tgcgctcgat ctcaagaatg acgggaagat cctttggaag tacgaaccca
     4981 agcaggatcc caacgtcatt ccgatcatgt gttgcgatac ggtcaatcgt ggcgttgcct
     5041 atggtgacgg caagatcatt ctcaatcagg ccgacaccac ggtcgtcgcc ctggacgcga
     5101 agactggcaa ggtcgtctgg tcggtcaaga acggcgacca gaccgatggc ggcaaaggcg
     5161 aatccggtac ggctgccccc gtcgtcgtca aggacaaggt gctcatcggc gtctccggcg
     5221 ccgaattcgg cgttcgcggc tggctggccg cctacaatct gaaagatggc aaactcgcct
     5281 ggaaagccta ttcggaaggt ccggacgcag acaccctgat cgatcccgag aagaccacgc
     5341 aactcggcaa gccggttggc aaggattccg gcacgaacac ctgggaaggc gagcagtgga
     5401 agaccggcgg cggcacgaca tggggatggt attcctatga tcccaagctg aacctggtct
     5461 actatggcac cggcaatccc tcgacgtgga acccggtcca acgccccggc gacaatcgct
     5521 ggtcgatgac gatcatggcc cgcgatgcgg atactggtgt tgccaaatgg ctctaccaga
     5581 tgaccccgca tgacgaatgg gactatgacg gcatcaacga gatgatcctc gtcgatggca
     5641 tggaggtcaa cggcgccaag cacgacgtgc tggtgcattt cgatcgcaat ggttttgcct
     5701 acaccatgga tcgcgccacc ggcgaccttc tcgtcgccaa gaaatacgat ccggccgtga
     5761 actgggcgac cgaagtcgtc atggacccca agagcgaaca gtatggtcgc ccgcaggtcg
     5821 tggcgaaata ttcgacccag cagaacggcg aagacaccaa ctcgacgggc atctgcccgg
     5881 cggcgcttgg aacgaaggac cagcagcctg cggcttattc gccgaaaacc gggctgttct
     5941 atgtcccgac caaccatgtc tgcatggact atgagcctta caaggtgagc tacaccgccg
     6001 gtcagcctta tgttggcgcc acagtgtcga tgtatcccgc acctggcggc gacggcaaca
     6061 tgggcaactt cattgcctgg gatgcggcca agggcgagat cgtctggtcg aagcccgagc
     6121 agttctcggt gtggtcgggc gcgttggcga cagatggcga cgtcgtcttc tacggtacac
     6181 tcgaaggcta catcaaggcg gtcgataagg acggcaagga actctacaag ttcaagaccc
     6241 cgtccggcat catcggcaac atcacgacct acgagcaggg cggcaagcag tatatcgccg
     6301 ttctgtcggg cgtcggtgga tgggctggta tcggcctggc aggcggcctg ctttcgcctg
     6361 acaacgccgc tgcctggcat ggcgccgtcg atcagggccg cgcgcaaggc gaccaagccg
     6421 ctgtcgttgg tacagctggc ctgggtgccg tcggcggcta cgcggcactt gccgactaca
     6481 cgacgctggg cggtcagctc accgtcttcg gtctcccgga ttgatgcgct gggaaccttg
     6541 agcatgcctc aggtcttgtg agaccaaagg cttgaagaac gagagcccgg acatccggaa
     6601 gccatggccg ggctctcgat tcggttacgc acccaaaaac accgatcaat gccggtcgcg
     6661 acagcaaaac cgtgtccatt ggcaaatgaa ggaagcgttt gaatgtccgt tcgcattgta
     6721 atttcggctt tcgtcctggc tctgctgcct ctggcaagct cgagcctcgc ccgggccgac
     6781 gacagcatgg aaaaagccaa ggcggtaaag gaagaaggcg gcaagtattt ggatgcggat
     6841 ggaaatccga cctacaagat cgaaaacgga accgtcgatt ggtacacgtt cagcggctac
     6901 cgccggtatc attccgattg ccatgtctgc cacggacagg acgcgacagg ttcgagctat
     6961 gcgccggctt tggtcaacag cctgaaaacc atggattacg ccacattcct ctcgatcgtc
     7021 gccgaaggcc gcaagaatgt cggcggcggc aaggaaaacg tcatgcctgc ctttggcgac
     7081 aacaagaacg tctattgcta cctggacgat ctctacgtct atctgcgcgc gcgcgcagat
     7141 ggcgcggcgc cccgcggaag gccgcccaag cacgaagaca aggcccaggc ggcgaaggat
     7201 gccgaagcat cctgcatggg tggatgacat gatcggccgc gatgcattga agctgcgcgt
     7261 cgttctgccg atcctcggca cgctcgcctt gctgccgtcg aacgcgcatg cgcaaagcgc
     7321 cggccttggc gcggcgggag aactggtcga ccctgacatt ctgcgcgtct gcgccgatcc
     7381 ctcgaatatg cccttcaccg acaagagcgg cgaaggcttc gaaaacaagc tggccgaact
     7441 ggttgccgcg aaaaccgggc gcaagtccgt ctcctacacc tggtttccca cgatcaccgg
     7501 cttcgtgcgc aatacgttgg gggccaaccg atgcgacatc atcatgggct atgctcaagg
     7561 cgatgagctg gtgcagaaca ccaacgccta ctatcgctcc gcctatgtgc tggtgcatcc
     7621 gaaaagccac gatatggaag gcgtggaaac gatcgaagat cccagactca caggcaaaac
     7681 gatcggcgtc gttgaaagca cgccgccaac cgccaacatg gccgccaaca agcttctgcg
     7741 gaccgccaag atctatccgc ttgcggtgga tacgcgcgtc accccatcaa tgggggaggt
     7801 catgatcaag gacatgctgg cacacaagat cgatgcggcg gtgctgtggg gaccgatggc
     7861 aggttactac gccaaggaac tcggagctga tgtgacgatc gttccactgg tgaaggaaaa
     7921 aaccggctcg cgcatgtctt accgcatcac catgggcgta cgtccgtcgg accaggaatg
     7981 gaagcggacg ctcaaccggg tgatcaggga aaaccaggcg gagatcacca ggatcctgct
     8041 gagctacaac gtgccgctga tcgacgaaca cgacaacctg attacccaat gaatggaagg
     8101 gagactattt tcgtgctggt cgccgcgagc cttctgggtc tggccgagcc gacatgggct
     8161 ggcgacatcg ccgaacccag cggtttccgg atggacgact atcgggcgcc ggtgccgcgg
     8221 acgctgcaag gcgcgagggt ggtgacgacg gtggaagcgg aagcgctgtg gcgagcgaaa
     8281 aaggcgatct tcttcgacgt gatgccggac acgcccaaac cggccaattt gccggcaggg
     8341 acgatatgga gagacaaggt cagaaaggac attccaggca gcatatggct ggccaatgtg
     8401 ggatacggcg ctatttcgca ggagaccgcc agctattttc gccaaggcct cgcggccaag
     8461 gccgggacgg acaagtcgcg cacggttctg ttctactgca tgacgaattg ctggatgtcg
     8521 tggaatgcgg cgaaacgggc cgtccagtgg ggctacagtt cagtgatctg gtatccgctc
     8581 ggcgccgatg gatgggaaga tgcaaacctt ccactggagg agaaaaaacc ctacgcaacg
     8641 aacaattgaa ataaggactg caattattct cgatagtttg ttttcaattt ttcaaaacct
     8701 attgtttcat ttgtccattt ttgaaacttg atggacgagc cattgcgtcg gtgccctgca
     8761 atggttggct aacgacagga tcggtccctt cgggctggta taagaggaga aatgtcatga
     8821 agaagaactg gaaaaaaccg accatgtgtc aggttgccgc tggcttcgaa atttcacggt
     8881 atctgcctgc tgaaattact cccaagaagt aggccgcaga ggtgcgcgtc cctggcgaca
     8941 ggggcgcgca tcccctcccc gcatggaatt tccgtgaaag attttgacgc acgcaaagcg
     9001 cgcggactgt cgtttgtgac tgcaaattgc ctgcaggtca gagaagccgg cgcgcgggca
     9061 ttttcatgca tttgaggata atcggatcgg cggcgggcgg cggctttccg caatggaact
     9121 gcaactaccg tctcagtcgt gcggctcgca acggcatggc aagcgtgcat ccacgaaccc
     9181 agtcaagtgt cgccgcctcg gcggacgggt tgggctgggt tcttttcaat gcctcgcccg
     9241 acattcgcca gcaaatcgct gcaacacctg aattacaacc tgcgggcgat gcgccgctgc
     9301 gctcgacacc tattcgcgct gtggtgctga ccaatgccga cgtcgatcat atcgccggac
     9361 tgctcagcct gcgcgagcgg cagcctttcg ccatctatgc aacggcgcag gttctggcga
     9421 cgctggaggc gaattcgatt ttcaacgttc tcgatccagc gcttgtgccg cggcgcatcc
     9481 tgccgccggc gaaagagttg gccatctgcg acgcagaagg ccgcgatacc ggcgtaatga
     9541 tcgagccctt tcccgtgccc gggaagatag cactctatct ggaggataga gaccatccgg
     9601 atgccaattt cagctccgac gcaggtgaca cgatcggagt ccgaattgcc ggcatcggca
     9661 gccgcggctc cgtcttctat atcccaggct gcgcgcgcat cgatgcgcgg ctacgcgcgc
     9721 gtctcaccga tgccgcctgt cttttgttcg acggcacggt ctacaccgac gacgagatga
     9781 tcgtcgccgg cgtcggtcag aaaaccggcg cgcgcatggg gcatctggcg atctcgggag
     9841 aattgggttc gattgcaggc ttggccaatg tgaaggtcgg ccgtcgcgtc ttcgtccaca
     9901 tcaacaacac caaccccatc cttgacgaga gttccgccga acacgcggcg gtcaaggcgg
     9961 caggctggga aatcgcaaac gacggtatgg agatggaatt ttgagcgact tccgcgatgc
    10021 agccaaaggc ggactctcca cgagcgctct cgaagccgtg ctgaggcagg ttggcgccga
    10081 gcgctatcac aatcgccatc cctttcacca caggatgacc agcggcgcgt tgtcgaaggc
    10141 cgagatgaag gcctgggcgc tgaaccgcta ttgctatcag gcggtcatcc cacgcaagga
    10201 tgccatgata ctcgtacatg ccgaggatcc agcgtttcgt gccgcgtggc gcaagcggat
    10261 cgaggatcat gacggcgagg acggctggag cggcggcatc gcgcgctggc tgcatctggc
    10321 aacttcgctc ggcctggacg ccgaggccgt gaagagcgaa aggctggcac tgccggcgac
    10381 acgcttcgcg gtgggcgctt acctttcctt ttgcacaaac cggacgctgt tcgaggcggt
    10441 cgcgtcctcg ctgaccgaga tgttctcgcc actcatcatc ggcgagcggg tgccggcaat
    10501 gctggccaaa tacgactaca tcaccgagga tacgctggcc tatttcaagc aacggcccga
    10561 acaggcctcg cgtgacgccg acttcgccct tgactacgtg ctcagccacg ccgatacggc
    10621 ggagcgccag cagcaggcaa tcgatgcact ggtgttcaaa tgcgatatac tctgggccat
    10681 gcttgacgcg cttcaacacg cctatggcga gcggggaaac ataccgcccg gcgccttcca
    10741 gcccgaggca gccctgtgat ggcgctgcgc gaaagagctg tggtgtcgtt gcgatcggta
    10801 ccttcgctgc cgaagcacgt gcgcatacaa tacgatccct tgcggcaggc atttgccgtg
    10861 ctttcaccgg aaaagatatt ctggccgaac gatgtcagtc tcgacatatt gcgacgctgc
    10921 gatggacggt ccacggtcgg cgacatcatt gccggccttg ccgccgatta tgaggccgaa
    10981 caggaggccg tggcgaccga cgtcatcgcc ttcctgcagg aatggtcgga caagctgctg
    11041 gtgaggctat gagcacgccc ctcctccctc caatcggcat gctggcggaa ctgacgcatc
    11101 gctgcccgct gcaatgccct tattgctcca atccgctcga actgctcaag gccaatcgcg
    11161 aactcgacac agagacctgg ctcgccctgt tctcggaggc cgccgatctc ggagtgctcc
    11221 aggtgcatct gtccggtggc gagccgacac tgcgccgcga cctcgagcaa ttgatcgccg
    11281 ggcttgcggg gcgcggcgtc tacaccaatc tgattaccgc gggcgttggc atcgtcgagg
    11341 gccgtgtcga ggcatttgcc gaagccggtc tagaccatct gcaactgagc tttcagggcg
    11401 cgcggccggc gaccacggat cgcatcggca accacaaggg tgcccacgaa aagaagctgg
    11461 agacggcacg ccgcgcgcgc gcggccggtc tgcctcttac cgtcaacgcg ccgatccatc
    11521 gccataacat cgaggaggtg ccggaattca tcgatctcgc cctttcgttg ggcgcggaga
    11581 ggctcgagat cgccaatgtg caatatgccg gctgggcgtt gaccaatcgc gatcaactga
    11641 tgccggagcg tgaagcggtc gataggcagg cggagatcgt cgcggaggca caggagcggt
    11701 tggccggcat catcaacatc gattttgtga cgccggacta tttcgcgatc tatcccaagc
    11761 cgtgcatggg cggctgggcg cgggacgcct tcatggtgac gcctgacggc accgtactgc
    11821 cctgccatgc cgcacagacg atcccgtcgc tcagcttcga gcgtttcgaa ccacacaggc
    11881 tgtcctcaat ctgggccgat tcgccggcgt tcaatgcctt tcgcggtacg gactggatgc
    11941 aggagccatg ccgcggctgt gagcggcgcg agatcgactg gggcggctgc cgctgccagg
    12001 cgatggcgat cgccggcgat gccgctgcaa cggacccggc ttgcgcgaaa tcgccgatcc
    12061 atgctcgcat ggcaatgctg atcgacgaag ccaggcgcat tgccacagtt ccttcgagag
    12121 aagaagcatt cgtctaccgg cggatcggtg cggtgaccga atccgcctga cctggcgaga
    12181 aagcgcttct caccccctcg gcaagacgcg tagcgtctgc tcgtcaaaca atggctcgtc
    12241 ctggccgatg cgcacaaaaa gcaggctgtg cccctcaccc gcgggcacct cgaaatactg
    12301 catgccgtca ggcatttcac cccagtcgcc gcagggcggt tcgggaatct cgtcggagct
    12361 ggcaagtgct ttcagctctt tcgcataggc ggcgtcgggg ctgaatgtgt agcgtttgac
    12421 gccggcgggt accgtgccct cggtgtaagg cgccagcaca cagcgggcgc tgacggcctt
    12481 gtcggtcttt tccaggaaca ggcgctgcaa cgcagcctcg gcggtttcgc caggcttgat
    12541 gtcaaagacc tcgacaagag ggtcagccgc gccgccgtcg ctgtatttga tggcgagcgc
    12601 tttgccggcg aattcgaaat ggatctggcg gaaagccgaa atcgcagcgc tgcgtccagg
    12661 cggccagccc gacagttttg tcagacaatt tttcccaggc gcatttgtcg atgggcgggc
    12721 gcgacggcgc cggctcgtcc gccatggctg gtatcgtcgc ggatgcaagc agggcactgg
    12781 cccagatggt cgatcgcacg ctattcatcg ctgcatcctg ttaaaatgaa ggcgtcccag
    12841 gccgaaccgc ctggattggc attggcgaaa tcggctcctt cggtgaaagc cacgccgaaa
    12901 ccgggcaaga gcagccctct cggcgccggt gtcgcttcgc gcgaattcaa ctgctcggcg
    12961 ccgccgccgg tcaaggcata gacctggccc tcccatagcc tgcacaatcc gctaccgtcc
    13021 tgcaggccgc cttcccggtc gtcgtcggtg caggcgtggc gaatggtgcc gagcgggaaa
    13081 gaattcttgc cgttggtcca ggtgatgtcg gcgggcaggc tcgtgccggt tttgggcacg
    13141 gccagcgaaa acacttcggc cgtcagcgcc gccggctcgt tggcgagcgg ccggaattgc
    13201 acgacggcac ccgagcgcgg ctcctgatag gtggcgtgac tcaggaggca ttcttttgcc
    13261 aaggccgcct gcatcgggcc gagcaggccc aggaggaaaa aggccagtat gcgggtgatc
    13321 atccgatgtc tctgggaaag cgttgagtcg gcccgcacag tcgcatcatt cacgcaaaag
    13381 catagcaaaa tccggaacgg cggcgtttgt ccgctcctgg acaaaacttg tccacgcaaa
    13441 atcccaccag cctgtatggt cgagcgcact gatcgaagga gtggtgatgc ggcgtttggt
    13501 gatgacgacg gcaatatccg cattcgccgg tggctccgcg ctggcggcgc cgccttatgt
    13561 tgggacatgg tctaccgaca ggctgaactg ccacgcggct cccgacatcc aacgcgagac
    13621 tgtgttcaca gtggaccagg cgtcgctgtc gttccccgat ctcggctgcg agcaggcgac
    13681 atttcgcaaa agctcgaccg gctgggtggt gcatgccagc caatgctacg gttccgaccc
    13741 gtcgatcgag gagccgttcg cgcgtgtcat ccatatcgtc aggcatgggg ccacgctgcg
    13801 gttcacctgg cctggcttca acagcggacc gctcgtccgc tgttgaaggc gtccggcgcc
    13861 tcagaccagg ccgaccagaa aggcggcgcc accgagaaag cctgccgagc agatccataa
    13921 cagccagagc ccccgtaccc ggcattccag caccgccgag ccggggttgg cggggtcata
    13981 gtggacgtcg accttgctgc cttcgacata ctgccgtgcc tggccgccga cgaggccggg
    14041 caacgaagcc gtcacggttc cgccgaaggt cacacgatcg gcgctgtagc gctggccggc
    14101 gacgtcatag gagtagacga tgcgggattt gaagacggtg cgccagcgac catagccaga
    14161 atggtttcgg agcgcctgca ggcccgaggc atcgatgcgg ccggcagtga ccggccattt
    14221 tgccgcctgc tcggccatcg atttctggac gaagcccatg cgcaaggcaa acaggcccat
    14281 gaacagcagc agcgccgccg cgccgaggtt ttgcggcttg ggcaaatgcg gcctgatcgc
    14341 ctccaggacg ccgccgacgg aaaacaccag caccagcgca ccgaccacca gcccggccga
    14401 gagctggatc atgaacttga aggcgccttc gggcatggtg cgcttgatca cggctttgct
    14461 cggatcggcc ggattgtaga agacagtcac ctccgcgccg cggggaaact gggcaagggt
    14521 ttcggtgact tcgaaattcc ccaaattctc cttcacgctg tagcgcgagc tttgaaattt
    14581 cttgccgccg accttgtatt cgaaggtgat cgccggaaaa ttgcgcattt cggtcgtatc
    14641 agtgctgtcc gaaccaacgc ccgagcttct gacctcgcgt gcctcgacgc gcgacgagat
    14701 gatctttccc ggcgtcggca gccagcggct gagtgccttc acctctcgcc atttcatgaa
    14761 ggtgatgaac gacagcgcgc ccgcgaccac gcaggcaaag ccgacaagca tgatcttgag
    14821 ttccaactcg tctcccccca ggggtgcagg aacccgcaca tagacagcat ggcggcggca
    14881 atgtcttgta ttttcgcaaa tctgaaaagg ctgagcagcg caaacggcaa cagcccacgc
    14941 cgcgttatgc aggcttcacg gccaggaacg tgttccattc ttcgctattg cggccgacgt
    15001 tgaaatcgtc cctgatgagg accagcccgg cgccttcgag acgggcggcg aagtcgtccc
    15061 tgcgccagta gaccatgtga tattcgcctg atgtctcgcc atcgccattg cgcatcgaga
    15121 cgaggaaggc gccgcccggg cgcagcgacc cggctatctt ggcaagcacc tggtcggtct
    15181 ggtcgcgagg cacgtggatc aggacgcata gggcaaggac cgcgtcgtag gggccgccga
    15241 gatcatcggt gatgagatcg agcaactcgc catgcttacc acgcgcggcc tgcagctcga
    15301 gaaaccgctt ggtggcgtcg gtgcgccgaa ccttgacgcc caaattttcc agaaaatccg
    15361 catcgtatcc ggctccggac ccgacttcca aaatccggcc acctgtgccg gcgattgcca
    15421 ccaggcgctt gagcgatgcc tgctccctct cgttgggaac atggcgcacg atggcatcat
    15481 attgttccgc ataatcctcg taagcgctga tcgtttgacg gctctgtgcc agagcctccg
    15541 atgacacacc catcttttcc tcccatgcgt ccttgttggt caaagagcca gacactttcc
    15601 tcagcgaatg ctgccagcgg aagcgtgtcc atcgagcagt ccgatatcgc gcttgaaatg
    15661 gtccgacagc gcacgctggt caagcaggcc gcgtgagcgg gtcctgaagg gagcggcgaa
    15721 gaggtcgagg acggcggaca cccgagaaag cgaacgacgc caagcctgat agcttgtctc
    15781 agttggcgtc ggctaccgtc tgccggcccc cggcccaggc gcgccattgc cgttcgtcgc
    15841 catggaagac attgaggtct atgcggccag tgacgccgtg cgacaggccg gagccggaat
    15901 actgccagaa cagccatttg cgaccgggat agacctttga cggatgctgg gcgaccgcac
    15961 gcagccaaaa cggatagtcg aggaattcgc ccctgagatt gtcgcggtag aaatcgggcg
    16021 cggtgtagat gatgggccgc tggccgtaat agcgctccag cttgtccatg aacacctgca
    16081 tcttttccag caccttttcg cgcgacggcc gccgcttgca gctggactcg ccgttccact
    16141 cgacgtcgat caccggcggc agcgcgcctt cgaccctggg cacgttgcgg atgaaccagt
    16201 ccgcctgctc gcccgccgtg cggcaccagt agaagaaatg gtaggcgccg cgcttcaagc
    16261 cggcggcgtc ggcgttgcgc cagtttttca tgaacatcgg atcgaggtgg tcgccaccgt
    16321 cggtcgcctt gatgtaggcg aagttggcgc cctgcgcccg cagcttgtcc cagttgacgt
    16381 tgccttgcca acgcgagacg tcgacgccgt gcactgcaag gcggcgaggc gaacccttgc
    16441 cgaaattgat cggcttggcg tcgcgaaaac cgtaacgggt gagcggcccg gcaagcatgg
    16501 ccggtgccgc gcgggtcaat aacttgggcg gcgacaccaa ggctgccggc tcgaccggca
    16561 gcccgccgac atcaggcact tggggatcag gcgcatcagg tgcggcaaac acccccgtct
    16621 cttcctcctc cgccaagccg aacgggcgcg ttttttcccc cggaccgttg tcagacatgg
    16681 gagccagtcc ggcccttgcc gccctgttgc cccttgccgc cggagcagcg gcgatcggtg
    16741 ccggcggccg gatcacggaa ctggtggtct cgttggaggg tttctgcaaa tccagcgcat
    16801 cgacgccggc cgttgacgag cagccggcaa ggcatagcga tgctatcaaa aaactgacga
    16861 cgcccggaat ccgcatctgg acctgtactc aaaacacaac agaccgaggg cgaaacgaca
    16921 gccgacggac aaaccggatc agttatgaat gagaaattac caataaagtt tgaatcaagt
    16981 tttttttcgc cataccgcat gcgggtaagc gcggtggaaa ctggctcagg atttcctgaa
    17041 gacgccgatc atcggcccga gattccagta gtcgtctttg cggccgatgg caggcgcaaa
    17101 caggctggat atcgtgccgt cgaggaacag cgcgttatcg caaccgagcg cgtcgcggaa
    17161 aagccgggcg aaggcatgga aggtcaccgt gccattcgaa atcgcaaaga ccgcgacgcc
    17221 atcctttcgc accccgacac cgtcgcgggt tttccgcgaa gtgccgtcgg cctggaattt
    17281 cggatgcagc ttgccgtcga tcaccagcat cggccccgat tgcgtcgcat agtcgacggt
    17341 cgggcgcctc ttcacgaagt ccctggtggc gcggaccgcg gccctgccgt cgcgtatgta
    17401 gaaaatgccg ttcggctgca gggaaaagtt gccgcttccc gaacccgttt tcaccgacgc
    17461 catctcctgg ccgcgctcga catagagacc gaccggcgcg aggttcgggt gatacatgcc
    17521 ggcattgatg ccgaacagca tcgtgcgccc gatcgcttgt tgcgcggcat gcagattgtg
    17581 cagcgactga aacggcttgc ccgccgcatc cttccagaac agctcgagct gatatcgttt
    17641 cggatcgacc tcgcaaacga gatagctggt cgcctcgaag gtgaagtccc ggcatggcgg
    17701 cagcgagaca acccactggc cgaacgacgc gccaagcgcc gccaccgacg gcagcgcccc
    17761 cttggccatc gccagcaaca gtggcaccga ttgcaggagg gtcaaaaaat ccatgtgcgt
    17821 accggaatcg aagttcgagg tccggtacgg atatagcccg tttcaagcga tactgtggaa
    17881 ctgcttagac gagccatccc atggcgacgc tcgacaacaa gacgatgccg agcaggccgc
    17941 gatagatgac gaacggccaa gccgagaaac gctccagcac gcgcatcagc ccccatatgg
    18001 cgaagaaggc ggagatcgac gcgacgacca gcccgacagc aagcaccgac cagccatggg
    18061 cgtcgagatg gaccttgtgc agttcccaga gttccttgag gccggcgagc gcgatggcag
    18121 gcagcccgag caggaatgag aagcgcgccg cttcggcccg cttgaagccg agccccagtg
    18181 ccgctgtcag ggtcgagccc gagcgcgaga cgccggggac aagcgcgccg atctgggcga
    18241 taccgacgag cagcgcatcg gtcagcgacg catcgcccat gctgcgccgg tgacgggcaa
    18301 agatctcggc cagcgccagc aggatcgcca tggcgatgca ggcccagcct atcaccgtca
    18361 ggctacgcag cggcgaattg caggcgttga gcaggcccga cagcgcaacg ccggcgatga
    18421 cgatggggat cgtcgccagc acgatccaga gcgccagctt gaaatgccgg tcggcgaaat
    18481 cgcgtcgcgc cagagcgtcg agcgatccaa acaggatatc cctgacgtcg ctccagaaat
    18541 agctgaccac cgcggcaagg gccgcaagct gcatggcggc ggagaaggcg gagccaggat
    18601 cctgccagcc gagcacggcc ggcacgatgc gcatatgggc agtcgaggaa attggcagca
    18661 gttccgtgat gccttgcacc acgccgagga acgccacctt ggcgaacccc aggccgacga
    18721 agcccgtgtc gaggccttgg gtgcagatat cggccaaaat cgaattccgt gcatgagaga
    18781 tcggagttgc gtggaccgac catcggtcaa tcccgggcaa gccttatcgt catgggccgg
    18841 ataatcaatt tacggatttg taagctggca cgccgaggtg cacgccgttc gaaaaccggc
    18901 ccaccttggg gccggcttga ggcacacagg gaaaatcgca aagcgactac gggcagagcc
    18961 agagtttctg gcatgtcctg gcgatcacat gcgccggcgg cacttcgggc tcatcggtcg
    19021 aaggccggcg agcccgttcg agcagcatgc gcacctgttc gggacgcaca cgatcgcgct
    19081 ccatcacaag caggaccatc ggatctctca aaagctcgtc cagggtgctg atgctgtcgt
    19141 tcatccgtcg tctcctcgaa tgccgtaccc gcgaccctta aataggacga caaagatggc
    19201 tcgccaatga cgctttgccg gctatctcgt gtcgatttgg attaaatttt ggccatgctt
    19261 gcgctcttcc cttcccctgg cgctgcgcgt cgatccacct tcttccacaa caaggggaga
    19321 agggaaaaat tagcctggcg gaggggcgcc ttcgtatttc ggcaggccgt catcaagcac
    19381 cagccaaggc tgcttcgagg ccgtgaaaat atgcatttgc ggcttgaaaa ccgtgggatc
    19441 gtcgagcgaa ccggtggtga tgccgataat gcctgcggaa tcacgtcggg agaacagcgt
    19501 tgtgccgcag ctcgggcaaa agccgcgctt gagatccggt gaagagccta tagtcgccag
    19561 cggcccatcg atcgtcacgt cctcgatgcg aaacagcacg cgtgcgttga aggcggcgcc
    19621 gatcgccttc tggcaaagcc ggcagtggca gacgcgttcg ttgatgggag ccgcgtccgc
    19681 gcggtagcgc accgccttgc acaggcatcc gccctcatat cttgccattg tctggatcca
    19741 ctggtgggag agaataggcg cgcaacgtat cggcggggcc gattgggtca attgaaaagc
    19801 tttgatgcaa tgtcatcgct tgtgctgatg cgagttggga tgaagccatg acgccgaaag
    19861 ccgtcatgga gccacggaat gccggctgcc cgccaacagc cggcggtttt ggcgttcact
    19921 ccatttcgcc gacgacctcg tcccaggtct tgaccttggt ctggccgttt aggaacggca
    19981 gcgcggcggc cgtcagctcc ggggcgaaga agacatcgta gtgggtgcgg ttgggcagga
    20041 tcaccaggcg gttctgcgac aggttctcgc gcatccagcc ggcgtccttc agtccgccgc
    20101 cgagcatctg atagaacttg atctcgtgtt cgggcttata catatcgctg tcgccataga
    20161 ccagcatgac aggcatcttc agcttggcga catcggccga gtaatcgcgg ttctgacgca
    20221 tgaagccgcc cagcgcatcg aggagcttcg ggaactcctc cggatgcggc gccaccgcga
    20281 cgtaggattt gtacatcggc gtgtccttca tgaactcagc cgcggctgcg ctcacctgtg
    20341 cctgctgcgg acgcatctcg tcatagaagc cgtccgtggc gtagccggtc gataccagga
    20401 cgaggcggtg caccgcttcg ggatgctgga cggccatgcg gaaggcgacg ccgccgccta
    20461 gcgaatagcc catgacatcg acctggctgt aaccgagcgc cttgacgatg gcggccatgt
    20521 cgtcgcccat cgcctccacg gtgaatggtc ggtcacccag cgcggtgcgg ccgtgaccct
    20581 gcaggtcgac gccgatgacg gtgcggtttt cggcaagttt cggcaggatc ggcgcgaaca
    20641 tatccgtggt gccaagacca ccatgcagca gaagcagcgg ctcgcccttg ccatagatcg
    20701 catagtagta gttcaggccg ttgatcgtca gaaggccgga cttttccggc ttcggcagtg
    20761 cattcgtttc agtcgtcatg gcaggttttg tctcctctgc attggtgatg cccgggcagg
    20821 caagcagtgc tgcggccgaa gcaaaaatgg cgaaaaacag ggttttgaac atatcgatct
    20881 cctctcctgt cgatatcaag gcgttatgcg gatcaaagcg ttttggcgag ttcttcgagc
    20941 tggtcggcgc actgtcccca gccctcgtgg aaccccatct tctcatgctg ttcgcggtcg
    21001 gcgacgctcc agtgcctgac ccgagcgatg tagcgggtct tgccgttgcc ctcgtcctcg
    21061 aaggtcagcg cgacggtcat gaacggcttt tccgaaggct gccaagcctc agtgtaggcg
    21121 tcggtgagga cgatcttcct gccggcaacg acttcgagga agacacctgg gttggggaac
    21181 tcgttgccgt ccgggctggc catgacgaca aggctcgagc caccggcgcg cacatccatc
    21241 tccgcgcgcg gcgtcgtcca cggttttgga gagaaccagc gcgtgatcag tttcggatcg
    21301 gtccagcagc gatagacgtt ctcgcgcggc gcatcgatga tgcgggcgag aaccagttcg
    21361 cggtcgttgg tgggggcgat gtcgagcttg gtggtcatga tggcgtcctg cgtttgatct
    21421 ggcttccgtc ccaaggacga gccgatgaac cgcaagccga catcggccag cgaaaatttt
    21481 gcgacaccgt ttcgattgac ccgaggcgtc actcaccttc gtcatccacg ggcggagcag
    21541 gaacgcagct ccgtcgcgga gacccgagga tgacgaagtg atcgatgggc caaagcctca
    21601 gtggcgcttg gcttgcacca gataggcctc gatctcggtc tcgccgagcc actttgccgc
    21661 ttccagccgg tgcaggcctt cgacgaggat gtggcgcttg ccgtcatggc ggacctggat
    21721 cggcgtcttc atgccgtttt ccagaatgtc ctcggcgaga tggcggacgg tctcgggatg
    21781 cagcgtcttc ttgcgcgccg tcggcacgta gatctcgtcg accttgacct tttgcactct
    21841 gagcatgccg acccccgtgg cggaaacgcc gccaaccctg agatagtccg tttgatggag
    21901 gcggccaagg gtgcggctaa cgaatacgaa gtccgaaggc cattctcggt tcgaagatgc
    21961 cagggacagc agatcgtttg cctgtcgtcg cgcgtttcga tattgcgtct gcgcgatcgt
    22021 cgagggccac ggagcaaatc cccatgagca aatctctcgt cacctttgtc ggcgtcgctc
    22081 atccctggat gtgcgacgtg atggggcacg tgaatgtgcg tcactacgcg gcgatgttcg
    22141 atgatgccag cttccagctt ctcggccata
//
