LOCUS       NC_022873              26444 bp    DNA     circular CON 15-AUG-2024
DEFINITION  Bacillus thuringiensis YBT-1518, complete sequence.
ACCESSION   NC_022873
VERSION     NC_022873.1
KEYWORDS    RefSeq.
SOURCE      Bacillus thuringiensis YBT-1518
  ORGANISM  Bacillus thuringiensis YBT-1518
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 6002284)
  AUTHORS   Wang,P., Zhang,C., Guo,M., Guo,S., Zhu,Y., Zheng,J., Zhu,L.,
            Ruan,L., Peng,D. and Sun,M.
  TITLE     Complete genome sequence of Bacillus thuringiensis YBT-1518, a
            typical strain with high toxicity to nematode
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6002284)
  AUTHORS   Wang,P., Zhang,C., Guo,M., Guo,S., Zhu,Y., Zheng,J., Zhu,L.,
            Ruan,L., Peng,D. and Sun,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2013) State Key Laboratory of Agricultural
            Microbiology, College of Life Science and Technology, Huazhong
            Agricultural University, 1 Shizishan Road, Wuhan, Hubei 430070, P.
            R. China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 1.04
            Reference-guided Assembly         :: NC_005957.1
            Genome Coverage                   :: 190X
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497525.1-RS_2024_08_15
            Annotation Date                   :: 08/15/2024 02:37:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,968
            CDSs (total)                      :: 6,823
            Genes (coding)                    :: 6,362
            CDSs (with protein)               :: 6,362
            Genes (RNA)                       :: 145
            rRNAs                             :: 15, 15, 15 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 15, 15 (5S, 16S, 23S)
            tRNAs                             :: 95
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 461
            CDSs (without protein)            :: 461
            Pseudo Genes (ambiguous residues) :: 0 of 461
            Pseudo Genes (frameshifted)       :: 191 of 461
            Pseudo Genes (incomplete)         :: 266 of 461
            Pseudo Genes (internal stop)      :: 128 of 461
            Pseudo Genes (multiple problems)  :: 100 of 461
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:11:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3937211
            Orig. end                         :: 3963655
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP005935.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26444
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="11"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26444
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26444
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16444](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16444)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(255..268)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.07"
                     /tool="antismash"
     misc_feature    complement(927..938)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.51"
                     /tool="antismash"
     gene            1046..2095
                     /locus_tag="YBT1518_RS19610"
                     /old_locus_tag="YBT1518_19925"
     CDS             1046..2095
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="YBT1518_RS19610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19925"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_241752576.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.7e-45, bitscore:
                     153.4, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQWDMKELTHNGESYKKETGSHNVVVGIIDSGVDVDHPDLVKNLI
                     PGSKNFVPKGGLRGTEPEETGDINNINDINGHGTLVTGSIAANGEIKGVAPNTGIRAYR
                     VFGNKSADAAWVINAIIEAAKDDVDVINLSLGSYYVNGKVYENGKLVDNGWAEVEGYKR
                     AIEYANQRGSIVVASAGNDSINVANKQELNNFLKQKYEKEGKTYTGVGIEAPGELPGVV
                     TVSSTGPTGQRSVFSNYGEGFIDISAPGGDYRLWQQYGEEVWWNTGLFRQEEVLTTFNT
                     GRYLFAAGTSMAVPKVSATLALIINHYNYKNQPNRSISHLYKNGIKKDIAPDKASWGYG
                     QLDVYNAIK"
     gene            complement(2107..3561)
                     /locus_tag="YBT1518_RS19615"
                     /old_locus_tag="YBT1518_19930"
     CDS             complement(2107..3561)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002185398.1"
                     /locus_tag="YBT1518_RS19615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19930"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_043924693.1"
                     /transl_table=11
                     /translation="MLKKLSLKNQFILTFAAVIFLSIVSTVCTLILIYSFLFIYNEKSV
                     LPANHYEKQVPSIEKFVEMNGDKIVDLSYQKKIEKVIPMQGITYQVMNTNGNRLYGTLS
                     DELLKNDKEVYHKINTSTQNGKLITKYIPIMSNDQLVGVLAVRYILAASIDYYIEYVFI
                     IAFLIPFIFLTLYSYLLAKRLGKQLNKPIKEVIMASQKIKNKDLDFEIKYESENEIGIL
                     IDSFNSMKEELKNSLYVQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMEPMPNNQK
                     RLHHYLQTIKNNTERVLHLTEEMRRISEVDNPDFTLMICNIAPAEMIPEMLEEFKELAK
                     NEDIQLTYTLLIKPEEKNLKFALDPNRLHQILTNIISNSIRFTPKKGRINVQVEVKKDV
                     MSFSISDSGVGFNTKDIPFLFSKFYQGDLSRSNQLHHGLGLYIVEKLVEKHGGEIHAEN
                     NEIQGARISFTIHALFSNKKRNYELS"
     gene            complement(3561..4241)
                     /locus_tag="YBT1518_RS19620"
                     /old_locus_tag="YBT1518_19935"
     CDS             complement(3561..4241)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001014563.1"
                     /locus_tag="YBT1518_RS19620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19935"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023522741.1"
                     /transl_table=11
                     /translation="MNGTILVVDDESEIVDVLSDIFCDRGYKVLKAYNGEQALNHLKTQ
                     VDLVILDIMMPKMDGFEFCKVVREQIKCPILFLSAKHSEIDKVKGFTLGGDDYITKPFQ
                     VKELIARVEAHLRREKRERVNLQNQRFLGNLTINYLQHDVFIDGVKIDVTSKEFKILEL
                     LTVNLGQIFSKEQIYEKIWGLDAVGDLNTIIVHINNLRAKLSLGMSTYHIKTVWGVGYK
                     LEKC"
     gene            complement(4303..6150)
                     /locus_tag="YBT1518_RS19625"
                     /old_locus_tag="YBT1518_19940"
     CDS             complement(4303..6150)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128190.1"
                     /locus_tag="YBT1518_RS19625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19940"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_023522742.1"
                     /transl_table=11
                     /translation="MSIFSLALKNITRNFSLYIVYLVSSILSVTIFYMYAAFLSYPKVS
                     GIEQLLIACEFIILLFSCFFISYSYDHFLTERKKEIGIWKTFGASKKQLFIIIVLENTI
                     IGAISIVIGIILGIALSKSFFEFIGKSLFLSESFSYFFSPIATFFTVILFGVLFFFVSL
                     RSYYKIGRISVLELFQETKKTKDLPRFSKKKFIISLLILVISYVFILYATLPVLLFSFL
                     PLSALLLLGTYLFCSHGLVGTVSYLINKEKKHLNGIRMLIFISLRKKLYYNAKIIFLVS
                     IFLSMIMILISSIYLYSELNDQRMRSSHPQPAVFIVDKKQENTLESDLEKNFKGEVEGF
                     HKKKWEGVLLKSSKEEGQTLILQTDSFFIKNWTKTKKDNLLFSKKNANIDKLNIQTNKG
                     NTKLIVKNVVEGHAINPVSGIDNVVFVPADILNELEKGILPTQHVSFYTLDFKEDNKSY
                     SALKTLFEALPLEIKEQSSVRLLHYENTVQLTSVLWIIALFIGFILLIALSSLLWFKLY
                     EDISNDRKIFHALRKIGLNFNEIKKTLRVQIAIIFFVPIILGGINLFIAIYALQNILGG
                     FKIYSIILIFFIFLVFQLVFCFISNHVYYKKVVHEKNIN"
     gene            complement(6125..6904)
                     /locus_tag="YBT1518_RS19630"
                     /old_locus_tag="YBT1518_19945"
     CDS             complement(6125..6904)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128192.1"
                     /locus_tag="YBT1518_RS19630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19945"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023522743.1"
                     /transl_table=11
                     /translation="MIMLEAKGIEKVYKTKFREYPVLNNVNLTVHEGDFVGIMGPSGSG
                     KSTLLNVLSSLDFPSNGDITIKGQNLTNMDGDQLSNYRRENIGFIFQNYNLLDHLTIEE
                     NILLPAALRMGSKKGVRDKLNTLGNELNIESLLPKYPYEISGGQQQRAAIIRSLINDPY
                     LLFADEPTGNLDSKSAYDVLNILKTLNETHKTTILMVTHDSVAASFCNRVIFLKDGKIV
                     HEMQRSYEEKQFSFNQRILLYISKEVGENDVNIFTRT"
     misc_feature    complement(6866..6877)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.12"
                     /tool="antismash"
     gene            complement(6931..7689)
                     /locus_tag="YBT1518_RS19635"
                     /old_locus_tag="YBT1518_19950"
     CDS             complement(6931..7689)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000646187.1"
                     /locus_tag="YBT1518_RS19635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19950"
                     /product="ABC transporter permease"
                     /protein_id="WP_023522744.1"
                     /transl_table=11
                     /translation="MKALVISEWERLWNQKKSKWMLGIFTVIVFLQAWFLKYYGVGIYN
                     DGQQVPLNSWNFSWFLLKESSFLITLIFMPVCFLNSLNVEYNSGAYRLFLIRPFQRITF
                     LMSKWFSLSIMVLLYLFVVLFVGIVLGLVFFKADDAFMFYGQQKTAIEAILYTVQVYGL
                     FFIIQMCGLALASLISVIISNAVISFFLLIGIYIGCLYISQLSFFLLSVQSIFHALSTG
                     SNTLYVLILGIMIISVSVCISIWNKKEFTC"
     gene            complement(7709..8539)
                     /locus_tag="YBT1518_RS19640"
                     /old_locus_tag="YBT1518_19955"
     CDS             complement(7709..8539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161130.1"
                     /locus_tag="YBT1518_RS19640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19955"
                     /product="ABC transporter permease"
                     /protein_id="WP_023522745.1"
                     /transl_table=11
                     /translation="MRGLFISEFERLWTQKITWLILFFLPLMVVASVKYYLNWNQHTSP
                     GRPDYVTALNFPIISISEHLVVSFNIIAIILISTVIAYEVENGQLRMILIRPFSTSQLF
                     VAKLATILTTMFLYLTLFWIFNSIAGYLFFPKVDTLITFIDETKVSIAGAILYNLKYLF
                     ACFITMVCIVSVFTLIGALSRSTMITLGSGVAFIFFAIAIPQILEFSNQTIISANTVLH
                     LMYMSIVKIQHTGIAFILSTSNSINIYIVIVEAIYIFLFGMFAYLSFVKRDYFI"
     gene            complement(8536..9270)
                     /locus_tag="YBT1518_RS19645"
                     /old_locus_tag="YBT1518_19960"
     CDS             complement(8536..9270)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058380.1"
                     /locus_tag="YBT1518_RS19645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19960"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023522746.1"
                     /transl_table=11
                     /translation="MNNEIVLEANHLTKTVGGKTIVNDFSTKIYKGDICGFLGPNGAGK
                     TTVMRMFTGLIRPTKGAIKISGQDVNQNRQQALMNMGAIIESPIFFPYMTGRKMLQNLA
                     RLYPALSRKEQLEQVEAILSIVRLTEDANVKIKNYSLGMRQRLGIAQALLGDPDVILLD
                     EPANGLDPMGMRELRELILELREKKNLTFFISSHLLDEIQQMCDRLVIIRNGKLITQGR
                     KDELITDPTKRLEDVFVEMMTS"
     gene            complement(9367..9975)
                     /locus_tag="YBT1518_RS19650"
                     /old_locus_tag="YBT1518_19965"
     CDS             complement(9367..9975)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128197.1"
                     /locus_tag="YBT1518_RS19650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19965"
                     /product="flavoprotein"
                     /protein_id="WP_023522747.1"
                     /sec_met_domain="Flavoprotein (E-value: 2.3e-33, bitscore:
                     113.3, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQMKQLLSSKKILVGVSGSIAVAGIFQYLAILKANFSEVKVIMT
                     KSAIKLIPAETVKLYCNEVFVDEELTLSGKPGHVELARWADLLMVLPATGNTISKVAHG
                     LADDLLSTVILAHDKPVLFFPNMNKLMWEKKVVQNNVSLLGEYDHIVIPPLKTTAFEIA
                     TMSLKPNYVLPNNQEVLHILFKEFEKRKSVTVHETVEMH"
     gene            complement(10001..11356)
                     /locus_tag="YBT1518_RS19655"
                     /old_locus_tag="YBT1518_19970"
     CDS             complement(10001..11356)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001177658.1"
                     /locus_tag="YBT1518_RS19655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19970"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_023522748.1"
                     /sec_met_domain="LANC_like (E-value: 2.9e-70, bitscore:
                     235.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLTTEKKSFWLQGISIEKRNKALKLVRDIAERLKDPMYVEKIVM
                     EPDNIPNGGTLHPWDPITLSHGYPGTIMLFAELDRQFPEEGWDLIAHSHLIEIQKAIEK
                     QGVNSISMFGGVSGIAYATSYASRNYERYHIFLKKLNEFVLSQLHLVLNYQKEECGVHP
                     FMYDTIQGATGVGRYLLQNIQLESNSEALKKILNCFINMSNDIEVNGEVVPGWYVPYAN
                     QFLETDKILFPDGNFNCGHAHGMPGPLSLMALAIEQGIEVPGQKQAIRKMIDWLIRWQD
                     EGSWPARLSFKEVVNDQAYHVYPKRKGWCYGNPGVARALYLAGRSLKDQKSMKIALSSY
                     QDTLLQSEEEWDLASPTFCHGRAGLLQMSIRMAKDENGEISMQSIIKLIDYVMDAYDPQ
                     APFGFKDLQSNEQTSNELNKVGLLEGVSGVLLTLLSLSAVEEPWWDGVFLIS"
     gene            complement(11374..13257)
                     /locus_tag="YBT1518_RS19660"
                     /old_locus_tag="YBT1518_19975"
     CDS             complement(11374..13257)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129903.1"
                     /locus_tag="YBT1518_RS19660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19975"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023522749.1"
                     /transl_table=11
                     /translation="MKQILNHVPEDEKLSFINILKSFHYWPGLFKLLWETHRGYFFCVL
                     TLNFLNGLLPAALILTIQYLVNTVQNIYQNGYQDAYFTHVLPFFIAFALVTILTGVTGS
                     VLETYKQLYRNLLSNKINVKLIEKAKRLPYSSFDNPEIYNKLQRARQDSTYKPFAIFEE
                     LMGIIKSGITVISISGILMIWNWQFTLILILLPLISSWSIMKIGKEIFLISHKRAEETR
                     KQFYYYYLLTTDITVKEVKLFGLGNLLLKNYSNIFNLFYQQDRHLLLKKMRIDLFFQLI
                     SVAFVMFVQFMVVMDAVTGIIAIGSLIAYFQAVNTTQKTSNELMYMIFNMHQNNLYMTQ
                     LFSFLDIPEERDVSNNRDNTYIESISFEEKGIRFINVSFKYPGQKEYILKKVNFHIKPG
                     ETLALVGSNGSGKSTIVKLITKLYTDFEGIILLDGKSIHQYSTNEWQDKVSAIFQDFVR
                     YELDVKDNIGYGDYKKADQVMAIQAAAKKSGALKMINNLPNKMDTQLGKTFANGIQLSG
                     GQWQRIAISRAYMRDAGLYILDEPTAALDPEAEEEVFRDFKEITKNCMGLFISHRYSTV
                     RHATKIMVLDKGRVAELGTHNELLKVKGIYARLFELQAKNFINHSKIQVKV"
     gene            complement(13229..16444)
                     /locus_tag="YBT1518_RS19665"
                     /old_locus_tag="YBT1518_19980"
     CDS             complement(13229..16444)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128200.1"
                     /locus_tag="YBT1518_RS19665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19980"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_023522750.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.5e-173,
                     bitscore: 575.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.6e-24,
                     bitscore: 83.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4e-40, bitscore:
                     136.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISEKRKPIHTSNKTACNNIFEPLPFFMIRSPFLPFNALYQIKNQ
                     EVLIKKLREYAEMDYIKEAIAIASPSLLESLKHIHGDLSSRKTQQVISSVLRYMLRMTT
                     RPTPFGAFSGVASGEFKEKSLLEMSHFEQFKKRTRPDMEWLLGVVSSLEKNPSILQSLM
                     VSKNHAAYRVGNRLYLPFSTECGQLRKKDMEKKENISILYSEVVRKVLDLAETHIKVKE
                     LLQKLQNDYPGTEVKVMENFILQLVEQEYLITELRPPLTYDSPFDYVIDKLKIRVGENQ
                     IWEDLLKVKDLILVYDQLPLGKGLSVYNNLILLMKRIYEVTTPLQVDFALNTQDLAIGK
                     NVANDVSKAAQVLWSIADSGVGFPHLQKYHIDFLEKYGTTREVPLVELLSEELGLGAPA
                     TYKNPKGNRDGENFTLPLDEERNVQLSYMLIEAIHNQQKEIEITDEIISRIGIEKDTRY
                     APDSFEVYGELYATSQEELDNGKYTLCLSPNPGSHAAGSTFGRFLDILDPNVRRKIQQQ
                     EVEIDHQFNNDIVMVEGSFLPATGRSANVAIGKTTREVTVTLGTNGDDDTLQIPIDDIV
                     VGASLENFYLKSKKLGKRIKVVAGNVLNYQSGPNIYRFMREVSLNDLDHWRIFNWGNMT
                     SSPYYPRIRYKNITLSPAIWKLNRETIGMKNKPKSDDEFLILFEKWREKWTVPRHVYMT
                     YSDNRILIDLENILHLRELKNELFKQGRLQLRESLQDINKNCLSSPLGSHAMEVVFPLK
                     KMNDVAKRKSIGAVEDGKKEMVSEKMIYRLPGSEWLYVKLYVPQARENEFISKYMTSFS
                     NYIVQSGMAQSWFFMRYRDPDAHIRLRFYGDPEKLNASVLTYLRDWANNLMDSGFIHKM
                     TVDTYEREVERYGGPYLIELAENFFHYDSRSVTMLLNVIGQQAELPVHVLASLNIIEIM
                     DNFGLTYEQQLETIESNTDKYEFIDEFRPMRKLLSNIGNSEGDWSNLRNYNSAIGQEIY
                     KSLLVRRESLKEYVSSIQQYKNEDMLWNKQQTIMGAIIHMHCNRLLGANRELEKKALAF
                     TRHILSSQRYWRNQNETDTQSRT"
     aSDomain        complement(15668..15958)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_YBT1518_RS19665_Lanthipeptide_LanB_RR
                     E.1"
                     /evalue="2.60E-26"
                     /identifier="RREFam001.1"
                     /label="YBT1518_RS19665"
                     /locus_tag="YBT1518_RS19665"
                     /protein_end="259"
                     /protein_start="162"
                     /score="83.1"
                     /tool="antismash"
                     /translation="MVSKNHAAYRVGNRLYLPFSTECGQLRKKDMEKKENISILYSEVV
                     RKVLDLAETHIKVKELLQKLQNDYPGTEVKVMENFILQLVEQEYLITELRPP"
     gene            complement(16530..16670)
                     /locus_tag="YBT1518_RS19670"
                     /old_locus_tag="YBT1518_19985"
     CDS             complement(16530..16670)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="YBT1518_RS19670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19985"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_023522751.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.2e-18, bitscore:
                     63.9, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 4.7e-08, bitscore:
                     31.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINEKNLFDLDVQVTTATGDVDPQITSISACTPGCGNTGSFNSFC
                     C"
     CDS_motif       complement(16599..16670)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEKNLFDLDVQVTTATGDVDPQ"
                     /locus_tag="YBT1518_RS19670_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16530..16598)
                     /prepeptide="core"
                     /locus_tag="YBT1518_RS19670_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.60"
                     /molecular_weight="1998.3"
                     /monoisotopic_mass="1996.9"
                     /core_sequence="ITSISACTPGCGNTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEKNLFDLDVQVTTATGDVDPQ"
                     /leader_location="[16598:16670](-)"
                     /alternative_weights="2016.3"
                     /alternative_weights="2034.3"
                     /alternative_weights="2052.3"
     gene            complement(16720..16860)
                     /locus_tag="YBT1518_RS19675"
                     /old_locus_tag="YBT1518_19990"
     CDS             complement(16720..16860)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="YBT1518_RS19675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19990"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_023522752.1"
                     /sec_met_domain="TIGR03731 (E-value: 3.4e-16, bitscore:
                     57.4, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 7.6e-08, bitscore:
                     30.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINEKNLFDLDVQVTTATGDVDPQITRISACTPGCGNTGSFNSFC
                     C"
     CDS_motif       complement(16789..16860)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEKNLFDLDVQVTTATGDVDPQ"
                     /locus_tag="YBT1518_RS19675_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16720..16788)
                     /prepeptide="core"
                     /locus_tag="YBT1518_RS19675_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="11.60"
                     /molecular_weight="2085.4"
                     /monoisotopic_mass="2083.9"
                     /core_sequence="ITRISACTPGCGNTGSFNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEKNLFDLDVQVTTATGDVDPQ"
                     /leader_location="[16788:16860](-)"
                     /alternative_weights="2103.4"
                     /alternative_weights="2121.5"
     gene            17101..17274
                     /locus_tag="YBT1518_RS37620"
                     /old_locus_tag="YBT1518_19995"
     CDS             17101..17274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030236.1"
                     /locus_tag="YBT1518_RS37620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_19995"
                     /product="hypothetical protein"
                     /protein_id="WP_023522753.1"
                     /transl_table=11
                     /translation="MNKALWEFLMEMKKNKLTFENYELCPSLETLSVEERIVLDEYAKD
                     FRVKNDGGNQWV"
     misc_feature    complement(17145..17158)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 20.81"
                     /tool="antismash"
     gene            17249..18217
                     /locus_tag="YBT1518_RS19680"
                     /old_locus_tag="YBT1518_20000"
     CDS             17249..18217
                     /EC_number="4.2.3.-"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129906.1"
                     /locus_tag="YBT1518_RS19680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20000"
                     /product="class 1 isoprenoid biosynthesis enzyme"
                     /protein_id="WP_023522754.1"
                     /transl_table=11
                     /translation="MMVEISGFRDCLINHIAYHISYRNQSDESEILLFIQKCLSQKGKV
                     LNPESSGFSWGELYLALSFLTKRQPITKRELDKAMGIEFIFLSADIIDDLCDGDILNPL
                     YFKNEYPRFLLVSQYLLMQGLIYLTYKTKDTATGDLLQQLIHSCCGEWKDIQFCFSIDK
                     KIILSEEEYMKLIEKKSGLLTETIFRTINPENRILKEITSYIGIAGQLRNDANDAMTDN
                     KNDLQELKAYLPFLKAYEYSYITQDDFFKNLTDKQISSSPEVRALVRDYIEQSGALHYC
                     RVLSRLYYRKAFALLEKNFILSTDEMTYFQMMVIGRDYFYA"
     gene            18210..20351
                     /locus_tag="YBT1518_RS19685"
                     /old_locus_tag="YBT1518_20005"
     CDS             18210..20351
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001244598.1"
                     /locus_tag="YBT1518_RS19685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20005"
                     /product="sensor histidine kinase"
                     /protein_id="WP_023522755.1"
                     /transl_table=11
                     /translation="MRNIGFCIPLSILYLLILLTNNYYFHSSNFKESVNSLLISHFYMI
                     SVISLIFFTIGLISCLKKRQSIVAKKFFSLTSVFGIAILTSLLSSYDINIFKAIEVSSI
                     FMLSYLLISFFSNFPVSTKPKYVKIFNLVSFLISTGLTIIYIFFCCFGYMSNNNFSFLF
                     KVLLITNLFLSISICVFLISLHLRENNLKVKSQLYILIFGIILSFLPIVLLNLIPGLLF
                     GESKIPFTYCLPSIIIFPLTISYLLIKQEVIEFEIRISKWLTNSLFYLLNLFLLNLSVE
                     QFIDLSQKEIFILCSLSVLSVVLSVYIYKLILSLFRYFNIKNDAQSGLHKIELFQTLSK
                     EKHAKELAKLIGQLINQMFNINGVSIIWNSNSIYHSLYETGIFQDMDKFELFNQLNQLE
                     QNLLLKEGTTPIHIQFEKYHLICFPILIYQGMQGAIIIGEKNDYTLFKPKEINELEEVV
                     INSANLLLSVNTLNSNKKEIRKAKVKAQNWKQFNYQIIQSLEDERKRLSIFLHDEILQI
                     LILQLNEIRMLQTKRNFSIDILNSMDEQLEDIIYSIRKMCHNLHPIIVEDLGLEASLHT
                     LKREFELNYRILIHIQFNCKLKILSKNLEIQIYRIIKELLNNAIKHSKGNNVQIHIIEE
                     KGCYVCTVEDDGIGFCVPNSFSEFSTSNHLGLMTIQRQVSELNGNLRISSEKDHGTLVT
                     FTIPVNWEEKNEYTYTTSG"
     gene            20323..20931
                     /locus_tag="YBT1518_RS19690"
                     /old_locus_tag="YBT1518_20010"
     CDS             20323..20931
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128205.1"
                     /locus_tag="YBT1518_RS19690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20010"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023522756.1"
                     /transl_table=11
                     /translation="MSIHTLLVDDHLLVMLGIQRLLESEEDIKVINTVNDPSILIKTVA
                     ETRPDVIVTDIRMKQYNGIELTKDLLAKFPDVKVVILSGYDHEEYYNAAFEAGASAYIT
                     KERSAFDLANAIRQSHMGYILFSKNQIMGNNIEALTSAEQRILHLISKDKTNYEISMDL
                     SISKRTVEYHISSIIRKLGVDSRVGAVVKGIKKGLIEGF"
     gene            complement(21645..21848)
                     /locus_tag="YBT1518_RS19695"
                     /old_locus_tag="YBT1518_20015"
     CDS             complement(21645..21848)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000810191.1"
                     /locus_tag="YBT1518_RS19695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20015"
                     /product="hypothetical protein"
                     /protein_id="WP_023522757.1"
                     /transl_table=11
                     /translation="MKQKTVQTCSNCGSHNIGEGEFVGYAQIRKKETMFTSSPVDAYIC
                     TDCGSILLLKVRNYQKFKQKPL"
     gene            22001..22807
                     /locus_tag="YBT1518_RS19700"
                     /old_locus_tag="YBT1518_20020"
     CDS             22001..22807
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000214346.1"
                     /locus_tag="YBT1518_RS19700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20020"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_023522758.1"
                     /transl_table=11
                     /translation="MTTVITLGIATEIENAEIDMLSSRLERLQTISGNPMQVQMKKFGS
                     ATAFSSKIIAGPAFNTVKGITNADAIDAIISYYESLQIPCRFEITPAQGTTELFQYLSQ
                     KGFYQSSFHTALYSIPREGSSLLPSNITIRKLKENEFDIFADIYVHGFNMPSFTKDSMR
                     QNNEILYNEPGWHFFIAEVQNIPAGIGVLYINKGVASLAASATLPEFQRKGCHTALIQK
                     RIKTAIESNCTLIVGQARFGSGSQNNMERAHMKIAYTKSIWTAKDI"
     misc_feature    complement(22930..22942)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            22979..23191
                     /locus_tag="YBT1518_RS19705"
                     /old_locus_tag="YBT1518_20025"
     CDS             22979..23191
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000160420.1"
                     /locus_tag="YBT1518_RS19705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20025"
                     /product="CsbD family protein"
                     /protein_id="WP_000160410.1"
                     /transl_table=11
                     /translation="MTKHDHGLKEKVEGAIDKVKGEVKEVVGKVTDNKKLQAEGKWDKV
                     KGTAKDTVGNVKEKVHEYKEHKKEK"
     gene            complement(23216..23464)
                     /locus_tag="YBT1518_RS19710"
                     /old_locus_tag="YBT1518_20030"
     CDS             complement(23216..23464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000981064.1"
                     /locus_tag="YBT1518_RS19710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20030"
                     /product="DUF2164 domain-containing protein"
                     /protein_id="WP_000981066.1"
                     /transl_table=11
                     /translation="MMNIKIPNDKKEELVAQIQQFFMEEDLDEIGRFQAERLIEEMIKL
                     VGPFAYNQAIGDARKLVSEKLTNMEEDLYVLEKNEGK"
     gene            complement(23484..23936)
                     /locus_tag="YBT1518_RS19715"
                     /old_locus_tag="YBT1518_20035"
     CDS             complement(23484..23936)
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000402975.1"
                     /locus_tag="YBT1518_RS19715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20035"
                     /product="peptidoglycan recognition family protein"
                     /protein_id="WP_000403999.1"
                     /transl_table=11
                     /translation="MEIKRVNLTFQDELVPLEKVNKLIIHHTAEDGWDVYKTHEFHQTV
                     RGWSGIGYNYFIEKDGTVVEGRGLHIGAHAKDHNRHTIGICMTGNFDKYDPTPAQVNAL
                     YSLCKLFMKQFAIKKENILGHRELEGVTKSCPGNRFSMVELRKILS"
     gene            complement(23952..24773)
                     /locus_tag="YBT1518_RS19720"
                     /old_locus_tag="YBT1518_20040"
     CDS             complement(23952..24773)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002028193.1"
                     /locus_tag="YBT1518_RS19720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20040"
                     /product="protein phosphatase 2C domain-containing protein"
                     /protein_id="WP_002041632.1"
                     /transl_table=11
                     /translation="MKGDTVVKIKTYQQKSPLKQECEDSYFCNKEKKIYGVCDGATPLV
                     PFRDEKGHNGAYIASHLFASYFTALRENHSLQFAVAKANEALQSKMLEYEVDTRKKEHL
                     WCTCIAAVQIVGEKIEYAQLGDCMIVATFQNGTMQVLTKDTVEGISKRAKKKREEDRKK
                     GLSVPEEYVFQDVREQLKYNRYLANMPNGYSVANGMKEAIHYLQHGELHTDEVSGIFIC
                     SDGLFHPDWSLEQTVAYIRKNSINEYIAIIEELEAEKRIRPDDKTIIMIDF"
     gene            24900..25709
                     /locus_tag="YBT1518_RS19725"
                     /old_locus_tag="YBT1518_20045"
     CDS             24900..25709
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000251344.1"
                     /locus_tag="YBT1518_RS19725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20045"
                     /product="YitT family protein"
                     /protein_id="WP_000251344.1"
                     /transl_table=11
                     /translation="MVRFLGVIIGSIIIAVAFNLFLIPHKILSSGIGGIAIILGIVTPV
                     NTGIINFVLNLPILILGYIGLGKKVIFNTVVSVVVLSVALYYVPVKVVATDPLLSSIFG
                     GVIAGAGIGLVFNCNGSTGGFDIIGMLLSRKRDIKLGGFLIILNAVVVIIAGFFFTWDV
                     ALTSLLSIYVTGKVIDAVHTKHRKVTLMIVTNEAEKMKKQLLSTVVRGITLLDGEGAYS
                     SEKKRVLMTVVSREELASMKLTISEIDPNAFVNITETVEVLGLFRRS"
     gene            complement(25729..26100)
                     /locus_tag="YBT1518_RS19730"
                     /old_locus_tag="YBT1518_20050"
     CDS             complement(25729..26100)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017763509.1"
                     /locus_tag="YBT1518_RS19730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_20050"
                     /product="VOC family protein"
                     /protein_id="WP_000800772.1"
                     /transl_table=11
                     /translation="MKNYIQGIDHVQVAAPVGCEEEARDFYGNTIGMEEIPKPEELKKR
                     GGCWFKCGNQEIHIGVERNFTPAKKAHPAFYVNEINEFKQTLIEQGVKVIDDYARPDVI
                     RFYVSDPFGNRIEFMQNKD"
     misc_feature    26199..26215
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 23.4"
                     /tool="antismash"
ORIGIN
        1 aaatgcttgg agaaaaggaa cagaaattag aaaacgtaag actgattcca ttgacgcaac
       61 cttaattgca gacgtgattc gctttggacg atttacagag acacctttag ctaatgaaac
      121 catgctggca ttaaaacaat tgagtcgttt cagaagctcc cttgtacata gcgtgagtga
      181 tttaaaacga aaagctattg tggtattaga tcagacattt ccggaatacc atacggtatt
      241 ctctgatatt tttggcaaaa catctgccga agttttaatg gaatatacta cccctagtga
      301 ttttgaacat gtctccgtag atcaattaac tgaaatgatg gaaaaagcta gtcgcaagaa
      361 gattggcgaa aataaggcaa aacatctcct tcaaatcgct tcacaatcct ttggtgtgac
      421 attttgtaaa gatgcttttt cttttcaatt aaaaatgtta ctcgaacaaa ttaaatttat
      481 tgaagagcaa attaaacatt gtgaacaaca aatgggtgag tacttagttg aactgaatac
      541 ccctatcacg accatccctg gaattggctc cattttagga gccactattt taagtgaaat
      601 tggtgatatt catcgttttg ataaacccgc taaacttgtt gcttatgcag gaattgatgc
      661 ctctatctct caatcagggc aatacgaagc atcgaaaagt agcatgtcta aacgcggttc
      721 ctctcacctt agacgggcat tatttcaagc cgccatttca ggatatcgga gcgatccagt
      781 tttaaaagcc ttttatgaaa aaaagagagc tcaaggaaaa cattattacg tctgtattgg
      841 agctgtagct agaaagttgt gttacattat ctatgccgtt ctgaaaaata ataaacctta
      901 cgagattcct catcatacac ccgaaagata accttttcat ttttttaact tcttaaggtt
      961 tatttggttt gccttttttc tgaaacaaca tcaaatattt tcattggatt tcacccttga
     1021 cttttcatag ttggtcttat gggatatgca gtgggacatg aaggaactta ctcataatgg
     1081 agaaagttat aaaaaggaaa ctggctctca taatgtggtt gttggaatta ttgattcggg
     1141 agtcgatgtg gatcatcctg acttagtaaa aaaccttatt cccggatcta aaaatttcgt
     1201 tccaaaagga ggattgagag gtactgaacc tgaagaaaca ggcgatatta ataatatcaa
     1261 tgatatcaac ggccatggaa ctctcgttac tggatctatt gctgcaaatg gggaaataaa
     1321 aggtgttgct cctaatacgg gaatcagagc atatcgtgta tttggaaata aatcagctga
     1381 tgcagcttgg gtcattaatg ccatcatcga agcagctaag gatgatgtag atgtcatcaa
     1441 ccttagtctt ggttcctatt atgtaaatgg aaaagtctat gaaaatggaa aacttgtaga
     1501 caatggatgg gcagaagtag aaggttacaa acgtgctata gaatatgcca atcaacgtgg
     1561 tagtatagta gtagcttctg caggaaatga ttctataaac gtggctaata aacaggagct
     1621 aaataacttt cttaaacaaa aatatgaaaa agagggtaaa acatatactg gtgtaggaat
     1681 agaagcacct ggggaattac caggagtagt aacagtatcg tctactggtc caactggaca
     1741 acgttctgta ttctctaatt acggagaagg attcattgac atatctgctc caggaggaga
     1801 ttatcgtttg tggcaacaat atggcgaaga ggtatggtgg aatactggtc ttttccgaca
     1861 agaagaagta ctgacaactt ttaatactgg aagatactta tttgccgctg gaacatcgat
     1921 ggcagttccg aaagtatccg ctacactagc tctaattatc aatcactata attataaaaa
     1981 tcaaccaaat cgatcaattt cacaccttta caaaaatgga ataaagaaag atatagcacc
     2041 tgataaagct tcttgggggt acggacagct ggatgtatat aatgctatta aataacggag
     2101 aaggaactat gacaattcat agttcctttt tttattacta aacagagcgt gtatcgtgaa
     2161 tgaaatccga gctccttgaa tctcattatt ttcagcatga atttctccac catgtttttc
     2221 aaccaatttt tctacaatat acaaacctag tccatgatgt agttgatttg accttgaaag
     2281 atccccttgg tagaatttac taaataaaaa tggaatatct ttagtattaa atccaactcc
     2341 agaatccgag atagaaaaag acataacgtc ttttttcacc tccacttgca cattaatcct
     2401 tccttttttt ggcgtaaagc gaatactatt agaaataata ttcgtcagaa tttgatgcaa
     2461 gcgatttgga tcaagtgcaa acttaagatt tttttcttct ggtttaataa gtaaagtata
     2521 ggttaattgg atatcttcat tttttgccaa ttccttaaac tcttcaagca tttctggaat
     2581 catttcagct ggagctatat tacaaatcat aagagtgaaa tcagggttat ccacttcaga
     2641 aattcttctc atctcttcgg ttaaatgcaa tactctttcg gtattattct ttattgtttg
     2701 taagtagtga tgaagtcgtt tttgattatt tggcatgggc tccattaata cttctacatg
     2761 agacaaaata atagtgagcg gtgttcgcaa atcatgtgca atggaagcaa ccatatcccg
     2821 acgttcctgt tctaatttcc attgaacata taatgaattt tttaattctt ccttcatact
     2881 gttaaatgaa tcaattaata tacctatttc attttcactt tcatatttta tttcaaagtc
     2941 taaatctttg tttttaattt tttgtgaggc cattattact tctttaatag gtttattcaa
     3001 ttgttttcct aaacgtttag ctaatagata agaataaagc gttaaaaata taaaaggaat
     3061 aagaaaagca ataataaaaa catattctat gtaataatca atagatgcag ctagtatgta
     3121 tcgtacagca agcacaccaa ctagttgatc attactcata attggaatgt attttgtaat
     3181 tagtttacca ttttgagtag aggtatttat tttatgatac acttctttat cgtttttcaa
     3241 taattcatca ctcaatgtac catataacct atttccattc gtattcataa cttgataagt
     3301 aattccttgc attggaatca ctttctctat ttttttttga taggataaat ctactatttt
     3361 atctccattc atttctacaa atttttcaat gctaggcact tgtttttcat aatggttggc
     3421 aggtaaaaca gatttttcat tataaataaa aagaaaagag tatattaaaa ttaacgtaca
     3481 aaccgtactg acaatactta aaaatattac agctgcaaat gttagaataa attggttttt
     3541 caacgataat ttttttaaca ttaacatttc tccaacttat agccaactcc ccatacggtt
     3601 ttaatatggt aagttgacat acccaaactt aatttagctc ttaagttatt aatatgcact
     3661 attattgtat tgagatctcc tactgcatcc aatccccaaa ttttctcata aatttgttcc
     3721 ttagaaaaaa tttgtcctaa atttaccgtt aaaagctcta atattttaaa ctctttactc
     3781 gttacatcta tttttactcc atcaataaaa acatcatgct gtaaatagtt aatggtcaag
     3841 tttcctaaga aacgttgatt ttgcaagttt acacgttctc ttttctcacg cctcaagtgg
     3901 gcctccacac gtgcgatgag ctccttaact tggaatggtt ttgtaatata atcatctcca
     3961 cctaaagtaa agcctttcac tttatctatt tctgaatgtt tagcactcaa aaatagaatc
     4021 gggcatttta tttgttcacg aacgacctta caaaattcaa aaccgtccat ttttggcatc
     4081 ataatatcta aaatgactaa atcaacttgt gttttcaaat gatttagagc ttgttctcca
     4141 ttgtaagcct tgagaacttt ataaccccga tcacagaata tatcagagag tacatctaca
     4201 atttctgact catcatctac aacaagaatc gttccattca aaaaaacact cctctctagt
     4261 ttattttaaa actcttatta ttttgtgaaa tatattttct tgctaattaa tattcttttc
     4321 atgaacaacc ttcttataat aaacgtggtt tgaaatgaag caaaatacca attggaatac
     4381 caagaaaata aaaaatatta atattattga gtaaatttta aatcctccca atatattttg
     4441 caaggcatag attgctatga atagatttat tcccccgaga ataattggta caaagaaaat
     4501 tattgcaatt tgaactctta atgttttttt tatttcattg aaattcaaac caatttttct
     4561 taaagcgtga aatatttttc tatcattaga tatatcttcg tataacttaa accaaagaag
     4621 actggataaa gcaattagca agataaaacc aataaataat gctattatcc ataaaactga
     4681 agttaattga actgtatttt cataatgaag aagacgaacg ctggactgtt cctttatctc
     4741 taaagggagt gcctcaaata aagtttttag tgcactataa ctcttattat cttccttgaa
     4801 atctaatgta taaaatgaaa catgttgagt aggtaatatt cccttctcta attcattaag
     4861 tatatctgct ggtacaaaaa ctacattatc tatcccagat accgggttta tcgcatgtcc
     4921 ttcaactaca ttttttacta tcaattttgt attcccttta tttgtttgga tattcaactt
     4981 atcgatatta gcattttttt tactaaataa caggttatct ttttttgttt ttgtccagtt
     5041 ctttataaag aatgaatctg tttgtagtat aagagtttgt ccttcttcct ttgatgattt
     5101 cagtaataca ccttcccatt ttttcttatg aaatccctca acctctcctt tgaaattttt
     5161 ttctaaatca gattctaatg tattctcttg ttttttatca acaataaata cagctggctg
     5221 tgggtggcta cttcgcattc tttgatcatt caactccgaa tataaatata tagagctgat
     5281 taatatcatt atcattgata agaatattga aacaagaaag atgattttag cattataata
     5341 aagttttttc cttagactta taaatattag cattcgaatg ccatttaaat gttttttttc
     5401 tttattaatt aaatacgata cagttcctac taatccgtgt gaacaaaaaa ggtacgtccc
     5461 taacaataaa agagcagata aaggcaaaaa agaaaataat agtacaggta aagttgcata
     5521 aaggataaaa acatacgaaa taaccaaaat taacagggaa attatgaatt tcttcttaga
     5581 aaacctaggt aaatcttttg ttttttttgt ctcttgaaat aactccaaaa cagaaatgcg
     5641 tccaatttta taataactac gtaatgaaac aaaaaagaat agaactccaa acaaaataac
     5701 tgtaaaaaaa gtagcaattg gagagaagaa ataggaaaat gactcactta agaagagcga
     5761 tttcccgatg aattcaaaaa agctttttga tagtgctata ccaagtataa ttccaattac
     5821 gatagaaatt gctccaatta tcgtattctc taaaacaatg ataataaata attgtttttt
     5881 agaagctccg aacgttttcc aaataccaat ttcctttttc cgttcagtaa gaaaatggtc
     5941 ataagaatag gaaatgaaaa aacatgaaaa tagcaggata atgaattcac atgcaattaa
     6001 cagttgctct attccagaaa cttttggata tgaaagaaat gctgcataca tataaaaaat
     6061 tgtaactgat agaatactac ttacaagata cactatatac agtgaaaaat tgcgagttat
     6121 atttttaagt gcgagtgaaa atattgacat cattctcccc cacttcttta gagatataca
     6181 gtagtatacg ttgattgaaa ctgaattgct tttcttcata ggaacgttgc atctcatgaa
     6241 caatcttgcc atctttcaaa aatatgaccc tgttgcaaaa actagcagct acagagtcgt
     6301 gagttaccat taaaatagtt gttttatgtg tttcattcaa tgtttttagt atattcaata
     6361 catcataagc agattttgaa tctagatttc ccgtcggttc atcagcaaat aacagataag
     6421 gatcattaat taatgaacgg ataatagctg ctctttgttg ttgtccccca gagatttcat
     6481 agggatactt tggcaaaagt gattcaatat ttagttcatt ccctaatgta ttgagtttat
     6541 ccctgacacc ttttttactc cccattctta aagctgcggg tagaagaata ttttcttcaa
     6601 ttgttaagtg atctaacaaa ttataatttt gaaaaataaa accaatattt tcacgacgat
     6661 aattgcttaa ttgatcacca tccatattag ttaaattttg tcctttaatt gtaatatctc
     6721 catttgaagg aaaatcaaga gaggaaagta catttaaaag tgtagacttt ccactccctg
     6781 aaggtcccat aattcctaca aaatctcctt catgaacagt taagttgaca ttatttaaaa
     6841 ctggatattc tcggaattta gttttgtaaa ctttttcgat tcctttagct tctaacataa
     6901 tcatggtata cctccattct atcctgtgca ttaacatgta aattcttttt tattccaaat
     6961 gcttatacaa acgctaacac taataatcat gatacctaga atcagaacgt ataaagtgtt
     7021 acttcctgtg ctgagcgcat ggaagatact ctggacagat aataaaaaga acgataattg
     7081 actaatgtac aagcacccga tgtagattcc gatcagaagg aaaaagctaa taactgcatt
     7141 tgaaattatg acacttatta aactagcaag agctaagcca cacatttgaa taataaaaaa
     7201 caatccatat acttgtactg tatataatat cgcttctatc gcggtctttt gttggccgta
     7261 gaacataaaa gcatcatcgg ctttaaaaaa caccaaccca agtactatgc caacaaaaag
     7321 aacaacaaat aagtagagta acaccattat agaaagagaa aaccattttg acataagaaa
     7381 ggttatacgt tgaaaaggcc taattaaaaa tagacgatat gctcctgagt tgtattctac
     7441 atttaagcta ttcaagaaac atacaggcat gaaaatcaaa gtaattaaga aagaagattc
     7501 ctttaataaa aaccatgaaa aattccaaga atttagtgga acttgttgcc catcattata
     7561 aatccccact ccatagtact ttaaaaacca agcctgaaga aaaacaatga cagtaaaaat
     7621 ccccaacatc catttgcttt ttttctgatt ccatagtcgt tcccattcac ttataactaa
     7681 tgctttcaat taaactccct cctagttttc aaataaaata atctcttttc acaaatgaca
     7741 ggtatgcgaa cattccaaat aggaaaatat aaatcgcttc cactataaca atataaatgt
     7801 ttatactatt acttgttgaa agtataaatg ctatacctgt atgctgaatt ttaacgattg
     7861 acatgtacat aaggtgtagt acagtattag cgctaattat cgtttggtta gagaattcta
     7921 aaatctgtgg aattgcaata gcaaagaaaa taaaggctac tcctgatcca agagtaatca
     7981 tcgtacttct acttaacgcc cctattaatg taaatacaga aacaatacaa accatagtaa
     8041 tgaaacatgc gaagagatac tttaagttat ataatatcgc ccctgcaata gacaccttgg
     8101 tttcatctat aaatgttatt aatgtatcta cctttggaaa gaataaataa cccgctatag
     8161 aattaaaaat ccaaaacaaa gttaaatata gaaacatggt agttaatata gtagcaagtt
     8221 tagctacaaa caattgtgag gtagagaatg gacgaattaa aatcattctt aattgtccat
     8281 tttctacttc atacgctata acagtggaaa tcagtattat agcgataata ttaaacgaaa
     8341 ccacaagatg ctcagaaata cttattatag gaaaatttaa agcagtaacg taatctggtc
     8401 ttccaggaga agtatgttga ttccagttta agtaatattt cactgacgca actaccatta
     8461 aaggtaagaa aaacaagatt aaccaagtta ttttttgcgt ccaaagcctt tcgaattcag
     8521 aaataaaaag tcccctcatg atgtcatcat ctccacaaac acatcttcca acctttttgt
     8581 tggatctgta attaattcat ctttccttcc ttgcgtaata agttttccat ttctaattat
     8641 gacaagacgg tcacacattt gctgaatttc atctagtaaa tggcttgaaa taaaaaaggt
     8701 taaatttttc ttttcacgaa gttcaagaat taattccctt aactctctca tgcccatagg
     8761 atccaggcca tttgctggct catctaacaa aataacatca ggatcaccta gaagagcttg
     8821 tgcaatgcca agtcgctgtc tcattcctaa tgaataattt ttaattttca cattcgcatc
     8881 ctcagttaac cttacaatag atagtattgc ttctacttgt tccaattgtt cttttcgcga
     8941 aagagcaggg tataatctcg ctaaattttg tagcattttt ctacccgtca tatatgggaa
     9001 gaatattggt gattcaataa ttgcccccat attcatcaaa gcctgttgtc tattttgatt
     9061 tacatcttga ccacttattt ttatggcccc ttttgtcggg cgaattaatc ctgtaaacat
     9121 acgcataaca gttgtttttc ctgccccatt cggccccaga aaaccacaaa tatctccttt
     9181 atatatttta gttgaaaaat catttactat tgtcttacca cctactgttt ttgttaagtg
     9241 atttgcttct aaaactattt cattattcat ataaaatccc tccttatgga ctaatataga
     9301 agacaaatat aaaaaaaaaa taaagaaaag aaagaaaaaa ataaaaaact cacatttttg
     9361 tgagttttag tgcatttcaa ctgtttcatg tacagttact gactttcttt tctcaaattc
     9421 cttaaagagt atatgcaata cttcttgatt attaggtaaa acatagttcg gtttcaaaga
     9481 catagtcgca atttcaaaag ccgttgtttt caaaggcgga atcactatat gatcatattc
     9541 tcctaaaaga ctaacattat tctgaactac ttttttctcc cacattaatt tgttcatatt
     9601 aggaaaaaag agaactggtt tatcatgagc aagaatgact gtacttaata aatcatcagc
     9661 taaaccatga gctacttttg aaatagtatt tcctgtagcc ggtagtacca ttagtaagtc
     9721 tgcccatcta gccaattcca catgacctgg tttaccactt agagtaagtt cctcatcaac
     9781 aaatacctca ttacaatata atttcacagt ttctgcaggg ataagcttta ttgcactttt
     9841 tgtcatgata acctttactt cactaaaatt cgctttcaat atagctaaat attgaaaaat
     9901 cccagctact gcaatagatc cgcttactcc tactaatatt ttcttagaac tgagcaattg
     9961 cttcatttgg tccatactgt aacatcctct caatttttta ttaggaaatt aaaaatactc
    10021 cgtcccacca tggctcctct actgcgctta gacttaataa agttaaaagt acaccactta
    10081 caccttccaa tagtccaacc ttgtttaact cattggatgt ttgctcattg gattgtaagt
    10141 ctttaaaacc aaatggtgct tgaggatcat atgcatccat tacataatct attaatttta
    10201 taatggactg catcgatatc tccccatttt catcctttgc catcctaata gacatttgta
    10261 ataatcccgc tcttccatga caaaatgttg gagatgctaa atcccattcc tcctcacttt
    10321 gcaaaagtgt atcttgataa gaacttaaag ctattttcat ggatttctga tccttcaaag
    10381 atctcccagc caaatagaga gctcttgcta ctcctggatt tccatagcac caaccttttc
    10441 gctttggata cacatggtat gcttggtcat tgaccacttc tttaaaacta agcctggcag
    10501 gccacgaacc ttcatcttgc catcttatta accaatctat cattttacga atcgcttgct
    10561 tttgcccagg gacttcaatt ccttgttcaa tagccaacgc catcaaggaa agcgggccag
    10621 gcattccatg agcatggcca caattgaaat tcccatccgg aaatagtatc ttatcagttt
    10681 ccaaaaactg attggcgtac ggtacgtacc aaccaggtac aacttcacca ttcacttcaa
    10741 tgtcattaga catattaata aaacaattga gaattttttt gagtgcttct gaatttgatt
    10801 caagttgaat attttgcaac aaataacgcc ctactccagt agcgccctga attgtatcgt
    10861 acataaatgg atgaacacca cactcttctt tctgatagtt caatacaaga tgtaactgcg
    10921 ataatacaaa ttcatttaac tttttcaaaa atatatgata tctttcatag ttacgcgaag
    10981 catatgaagt cgcatacgca ataccagaaa caccgccaaa catagaaata ctattcacac
    11041 cttgtttttc tattgccttt tgtatttcta tcaagtgact atgtgcaata agatcccatc
    11101 cctcttctgg aaactgtcga tctaattctg caaataacat aatagttcct ggataaccat
    11161 gggataaagt aatggggtcc catggatgaa gtgttcctcc gtttggtata ttatcaggct
    11221 ccataacaat tttttctaca tacatcggat cctttaatcg ctctgctata tcacgaacta
    11281 actttaatgc tttatttctt ttttcaatac taattccctg taaccaaaat gatttttttt
    11341 ctgtagttaa tcgcatagtt ttctcctctc taattacacc ttcacttgaa ttttagaatg
    11401 atttataaaa tttttagctt gcaactcaaa tagtcttgcg tatattcctt ttacttttag
    11461 taattcatta tgagtaccta gttccgcgac tctaccttta tcaaggacca taatctttgt
    11521 agcatgcctt acagttgaat accgatgaga tataaaaagc cccatacaat tcttggtaat
    11581 ttctttaaaa tctctaaaaa cctcttcttc tgcttctgga tctaatgcgg cagtaggttc
    11641 atctagaata tataggcccg catccctcat gtatgctcgt gaaatggcga ttctttgcca
    11701 ttgtcctcca gataactgta ttccgttcgc aaaagtttta ccaagttgtg tatccatttt
    11761 gttaggcaaa ttattaatca tctttaatgc tccagatttt ttagcagccg cttgtatagc
    11821 catcacttga tcggcttttt tataatcacc atagccaata ttatctttaa catctagttc
    11881 atatctaaca aagtcttgga aaatggcact aaccttatcc tgccattcat ttgtactgta
    11941 ttgatgaatg gattttccat ctaatagaat aatcccttca aagtccgtat aaagttttgt
    12001 aattaacttt acaattgtag atttacccga accattagat ccgacaagag ccaatgtttc
    12061 acctggtttt atgtgaaaat tcactttttt taatatatat tctttttgac cgggatactt
    12121 aaaagagaca tttataaatc gaataccttt ttcttcaaaa gagatacttt ctatataagt
    12181 attgtctcta ttatttgaaa catccctttc ttcagggatg tccaaaaatg agaatagttg
    12241 agtcatataa agattgtttt gatgcatatt aaaaatcata tacattaatt cattagatgt
    12301 tttttgtgta gtatttacag cttgaaaata agcgataaga cttccaatag caataatccc
    12361 tgttacagca tccataacca ccataaactg cacaaacatt acaaaagcaa cactaattaa
    12421 ttggaaaaac aggtcaatcc tcatcttttt taaaagcaaa tgtctatctt gctgataaaa
    12481 tagattgaag atattcgaat aatttttgag aagcaaattg cctaatccaa ataatttcac
    12541 ttcttttact gtgatgtctg ttgttagcaa atagtagtaa taaaattgtt ttcgtgtttc
    12601 ttcagcacgc ttatgactaa ttaaaaaaat ttcttttcca attttcatga tggaccaaga
    12661 agagattagt ggtaacagaa ttaaaattag ggtaaactgc caattccaaa tcattaagat
    12721 accggaaata gaaatcacag ttattccact ttttataatc cccataagtt cttcaaaaat
    12781 ggcaaatggt ttatatgtgg aatcttggcg cgctctttga agtttattgt aaatttctgg
    12841 gttatcaaaa ctggaataag gtaatctttt tgctttttct attaatttta cattgatttt
    12901 attagaaaga agatttcggt aaagctgttt atatgtttcc aaaacggatc ctgtaacacc
    12961 cgttaaaatt gtaactagtg caaaagctat aaaaaacggt aaaacatggg taaaataagc
    13021 atcctggtac ccattctggt agatgttctg tactgtatta acgaggtatt ggattgtcaa
    13081 aatcaatgct gcaggtaata atccatttaa aaaatttaag gtaagcacac agaagaaata
    13141 ccctctgtgc gtttcccata aaagtttaaa taaaccaggc caataatgaa aagactttag
    13201 aatatttata aatgatagtt tctcatcttc aggtacgtga ttgagtatct gtttcattct
    13261 gattcctcca atatcgctgg cttgataaga tatgccgcgt aaaggcaagt gcttttttct
    13321 ctagttctcg attagctccc aatagtcgat tacaatgcat atgaataatt gctcccataa
    13381 ttgtttgttg tttattccag agcatgtctt catttttata ttgttgaatg ctggaaacat
    13441 attcttttaa ggattctctc cgaactaata aacttttata aatttcttgt ccaattgctg
    13501 aattgtaatt acgtaaatta ctccaatcac cttcagaatt tccaatgtta cttaataatt
    13561 ttctcattgg tctaaattca tcaatgaatt catatttatc cgtattgctt tctatggttt
    13621 ccaattgttg ttcataagtt aatccaaaat tatccatgat ctcaattatg tttaaggatg
    13681 ctaatacatg tactggcagt tccgcttgtt gtcctatcac attaagaagc attgttactg
    13741 acctactatc gtaatggaag aaattctcgg ccaattctat cagatacgga ccaccatatc
    13801 gttctacttc tcgttcatac gtatcaaccg tcattttgtg gataaatcca gagtccatta
    13861 aattatttgc ccaatccctt aaataggtaa gaacagatgc attcaacttc tcgggatctc
    13921 cataaaaacg caaacgaata tgagcatccg gatcacgata tcgcataaag aaccatgatt
    13981 gagccatacc actttgcaca atataattag aaaatgatgt catatatttt gaaataaatt
    14041 cattctctct tgcttgtgga acataaagct taacatatag ccattcactt ccaggcaaac
    14101 ggtaaatcat tttctcacta accatttctt ttttcccgtc ttcaacagct cctatacttt
    14161 ttcttttagc gacatcgttc atttttttca atggaaaaac aacttccatt gcatgactac
    14221 caagcggact gcttagacaa tttttattga tgtcctgtaa tgactctctc aactgtaatc
    14281 taccctgctt aaaaagttca ttctttaatt ctcgaaggtg aagaatattt tcaagatcaa
    14341 ttaaaatcct gttgtcgcta tacgtcatat atacatggcg tggaaccgtc catttctctc
    14401 tccatttttc aaataggatt aaaaattcat catcactttt aggtttattt ttcatgccaa
    14461 tagtctctct atttaacttc caaattgcag gagaaagagt gatatttttg taacgaatcc
    14521 ttggataata aggtgaagat gtcatattac cccaattaaa tattctccag tggtctaaat
    14581 catttagaga aacttctctc atgaagcgat aaatattagg gccactttgg taatttaata
    14641 cattaccagc tactacttta attcttttcc ctaatttttt agatttcaga taaaagtttt
    14701 ctaatgatgc tccaacaaca atgtcatcaa ttggaatttg caaagtatcg tcatctccat
    14761 ttgttccaag agttaccgtt acttctcttg tagtttttcc aattgccaca ttcgctgaac
    14821 ggccagttgc cggaagaaaa cttccctcta ccataacaat atcgttatta aattgatggt
    14881 caatctccac ttcttgttgc tgaattttac gtctaacatt tggatctaag atatctagaa
    14941 atcgaccaaa tgtgcttcct gctgcatgag accctggatt tgggcttagg catagcgtgt
    15001 actttccatt gtctaattcc tcttgcgaag tagcatacaa ttctccatat acttcaaatg
    15061 aatccggagc gtatcgagta tctttttcta ttccaattct gctaattatt tcatctgtaa
    15121 tttcaatttc tttttgctga ttatgaatag cttcaataag catatatgat aattgaacat
    15181 tacgttcttc atctaaaggc agcgtaaaat tttctccatc cctattccct tttgggtttt
    15241 tatatgtcgc gggtgctcca agccctaatt cctcacttaa aagttctacc aatggaactt
    15301 ccctggtagt tccatatttc tccaaaaaat caatatgata tttttggaga tgagggaatc
    15361 caactccact atcagctata ctccataaca cctgagctgc tttactaaca tcatttgcta
    15421 cgttttttcc aatggctaaa tcttgcgtat ttagagcgaa atcgacttga aggggtgttg
    15481 taacttcata aatcctcttc attaatagga taagattgtt gtaaacagaa agccccttcc
    15541 caagcggtaa ttgatcataa acaagtatta aatcttttac cttcagtaaa tcttcccata
    15601 tttgattttc accaactctt atttttaact tgtcaatcac ataatcaaat ggagagtcat
    15661 atgtaagtgg cggtcttagt tcagttataa ggtattcttg ttctaccaac tggagaataa
    15721 agttttccat tacctttact tctgtgcctg gatagtcatt ttgcaacttt tggagaagct
    15781 ctttcacttt aatatgtgtt tcagctaaat ctagaacttt cctaacaact tcactataca
    15841 aaattgaaat attctccttt ttctccatat ccttcttgcg aagttgtcca cattcagttg
    15901 aaaaaggtaa atataggcgg tttccgacac gataagcagc atgattttta ctaaccatta
    15961 aagattggag aatactagga tttttttcaa gtgatgaaac cactcccaat aaccattcca
    16021 tatcaggacg agttcttttc ttaaattgtt caaaatggct catttcaagt aaagattttt
    16081 ccttaaactc tccggatgct accccagaaa aagctccaaa aggtgttggg cgtgttgtca
    16141 ttcttaacat atatcgtaat acagaagata ttacttgttg tgttttccta ctacttaaat
    16201 caccatgtat atgtttaaga gattcaagca aagaaggact tgcaatggca atagcttcct
    16261 taatgtaatc catttctgca tattctctta attttttaat caatacttct tgattcttaa
    16321 tttgatataa cgcgttaaat ggtaaaaacg gggatctaat cataaaaaat ggtagaggtt
    16381 caaatatatt attacatgcg gttttatttg atgtatggat aggcttcctt ttttctgaaa
    16441 tcattttgaa tcttcctttc tgttctaatc aagtattgta ataggagaaa agagggacac
    16501 atctgtgttc cctctttttg ggcattcaat tagcaacaga agctattgaa tgaacctgtg
    16561 tttccacaac caggcgtaca agctgagata cttgtaattt gtggatctac atcgcctgta
    16621 gctgttgtta cttgtacatc taaatcaaaa aggttttttt cattaatcat tttcttttcc
    16681 ccctaaagtt tttttaagac aatatgtctt atttagcaat tagcaacaga agctattgaa
    16741 tgaacctgtg tttccacaac caggcgtaca agctgagatt cttgtaattt gtggatctac
    16801 atcacctgta gctgttgtta cttgtacatc taaatcaaaa aggttttttt cattaatcat
    16861 tttcttttcc ccctaaaaat tttttaagac gttatgtctt atgtgtctaa tttatcagat
    16921 aaatatccta gtagaatccg tatattccgc aagcttatat tgtaaattca cgcattataa
    16981 aataaaaaat atgtaaatta agtattgaaa atttaaggac tatattgaaa acatcccgtt
    17041 tttattgtat ttttttatac agaacaaaaa tacagaatat ttagaaagag ggttgttttt
    17101 atgaataaag cactatggga atttctaatg gagatgaaaa aaaacaaact tacctttgaa
    17161 aattatgaat tatgtccttc attggaaact ctatcagttg aagagcgaat tgtattagat
    17221 gagtatgcaa aggatttccg ggtgaaaaat gatggtggaa atcagtgggt ttagagattg
    17281 tttaatcaat cacattgctt accatatctc ctaccgtaat caaagtgatg aatctgaaat
    17341 acttctattt attcagaaat gtctttccca aaaaggaaag gttttaaatc cagaatcttc
    17401 cggtttctct tggggagagc tatatctagc tctttctttt ttgaccaaac gacaaccaat
    17461 aacaaagaga gaattggata aggcaatggg gattgaattt atttttttat cagcggatat
    17521 aatagatgat ttgtgtgatg gagacatatt aaatccatta tattttaaaa atgaatatcc
    17581 ccgttttttg ttagtttctc aatatttact tatgcaagga ctgatatact taacttataa
    17641 gacaaaagat actgcaacag gagatcttct ccaacaacta atacattcgt gttgtgggga
    17701 atggaaagat atccaatttt gtttttcaat agataaaaaa ataattttaa gtgaagaaga
    17761 atatatgaag cttattgaaa agaaatcggg tctactaaca gaaactatct ttcgaactat
    17821 taatcctgaa aatagaattt taaaagaaat cacatcatat atagggatag ctggccagct
    17881 aagaaatgat gctaatgatg ccatgacaga taataaaaat gaccttcagg aattaaaggc
    17941 ttatcttcct tttttaaaag cttatgaata tagttacata acacaagatg atttttttaa
    18001 aaatttaacg gacaaacaaa tttcttcttc acctgaagta cgggcattgg ttcgggatta
    18061 catagaacaa tctggagcac ttcactattg tcgtgtccta tctcggctat attatagaaa
    18121 agcatttgca ctcttagaaa agaattttat tctttctaca gacgaaatga cttattttca
    18181 aatgatggtt ataggcaggg attacttcta tgcgtaatat tgggttctgt attcctttaa
    18241 gcattttata tttactaata cttttaacga ataactacta ttttcactct agtaatttta
    18301 aagaaagtgt taactcttta ttaattagtc atttttatat gatcagcgtt attagtctta
    18361 tttttttcac tatagggtta attagctgtt taaaaaaaag acaatctatt gtagcaaaaa
    18421 aattcttttc tctaacatct gtctttggga tagccattct aacatcttta ttatctagct
    18481 atgatataaa tatttttaaa gctatagagg tgagtagcat ttttatgctt tcttatctat
    18541 taataagttt tttctctaat ttccctgtat ctaccaaacc aaaatatgtg aaaatattca
    18601 accttgtatc atttttaatt tcaacaggat tgactattat ttatatattt ttttgttgtt
    18661 ttggatatat gtctaacaat aattttagct ttttatttaa agttttacta atcactaacc
    18721 tatttctcag tattagcatc tgtgtttttc ttatttcatt acatttacga gaaaataatc
    18781 ttaaggtgaa aagtcaatta tatattctaa tttttggtat tatccttagt tttttaccaa
    18841 ttgttctact taatctgatt cctggtctac tttttgggga atctaaaatt ccatttacat
    18901 attgtttacc tagtattatt atatttcctt taactatttc ttatttatta ataaagcaag
    18961 aagttattga atttgagatt agaatttcta aatggctaac aaactcactc ttttacttgc
    19021 tcaatttatt ccttttaaat ttatcggttg aacaattcat agatttgtca caaaaagaaa
    19081 tattcatact atgcagctta agtgtattat ctgttgtact ctctgtatat atatataaac
    19141 ttattctctc attatttagg tatttcaaca taaaaaatga tgcgcaatca ggtttacata
    19201 agattgaact ttttcaaaca ctctctaagg agaaacatgc taaagagctt gcaaaattaa
    19261 taggacagct tattaaccag atgttcaaca ttaatggtgt gtctataata tggaactcaa
    19321 atagtattta tcattcatta tatgagacag gtatttttca ggatatggat aaatttgagc
    19381 tatttaacca attgaatcaa cttgaacaga atctgttact aaaggaaggt actactccta
    19441 ttcatattca gtttgaaaaa taccacttaa tttgttttcc aatacttatt taccaaggca
    19501 tgcagggagc tattattatt ggtgaaaaaa atgattatac attatttaaa cctaaagaaa
    19561 ttaatgaact tgaagaggtt gtaataaact cggcaaattt actattaagt gttaataccc
    19621 tcaatagtaa taaaaaagaa attcggaaag caaaggtaaa ggctcaaaac tggaaacaat
    19681 ttaactacca aattatacag tcgctagagg acgaaaggaa aaggctttcg attttcttac
    19741 atgatgaaat tcttcaaatt cttattttgc aattaaacga aataagaatg cttcagacta
    19801 agagaaactt ttctatagat atattaaatt caatggatga gcaacttgaa gatattatct
    19861 atagtattag aaaaatgtgt cataatcttc accctattat cgtagaagat ttaggcttag
    19921 aagcgagttt acacacacta aaacgcgagt tcgaattaaa ttatcgcatt ctcattcata
    19981 tacaatttaa ttgcaaatta aaaattctct cgaagaatct cgaaatacag atctatcgca
    20041 taataaaaga gctactgaat aatgctatta agcattccaa ggggaataat gttcaaatac
    20101 atatcataga agaaaaaggc tgctatgttt gtactgtaga agatgatggc ataggctttt
    20161 gtgttccaaa cagtttttct gaatttagta caagcaacca ccttggccta atgactatcc
    20221 agcgtcaagt ttccgagtta aacggaaatt tgagaatatc ttctgaaaaa gaccatggga
    20281 cattagtcac atttaccatt ccagtaaatt gggaggaaaa aaatgagtat acatacacta
    20341 ctagtggatg accatttgct agttatgcta ggcatccaaa gactactaga atctgaggaa
    20401 gatattaagg taattaatac cgtcaatgat ccttccatat taattaaaac cgtggcagaa
    20461 acccgtcctg atgtaattgt tacggacatc aggatgaagc aatataacgg cattgaactt
    20521 acaaaagatt tattggcaaa atttccggat gtaaaggttg taattctatc aggatatgat
    20581 catgaagaat attataatgc ggcctttgaa gctggagcaa gtgcatacat cacgaaagaa
    20641 agatcagcat ttgacctagc taacgccatt cgtcaaagtc acatgggata tatactattt
    20701 tctaaaaatc aaattatggg aaataatatt gaagcactaa cttctgctga acaaagaata
    20761 cttcacttaa tctcaaaaga taaaacaaat tatgagatta gtatggacct ttccatcagc
    20821 aaaagaactg tagaatatca catttcttca attattagaa aattgggtgt agattcaaga
    20881 gttggagcag tcgtaaaagg gattaaaaaa ggattaattg agggttttta attacaaaag
    20941 gacattgcaa aacagttcca ttacaaagtc tcttgaaaga taaggtaatg cggaagtata
    21001 gctcattact accagagcca taaaatgaag aaataggtcc cagtgatgaa ggcctatttc
    21061 ttcattttaa acaactgtta tcctaatcat ttattgatat tttttaaaac cccaaaaata
    21121 aaatcctttc ttacattaac tgttacgcat acatcggaaa cttaaaagct tctcacaacc
    21181 tccatataaa tatgcctcct ttgttttgat aactaaactg tatgtaaaca ccgttcctat
    21241 ttctatatac tttatcaagt tatgattaca ctgatgttat ttaggaggtt ttatattatt
    21301 cacctgtcca ccttatattt tgacttcata gcgtacattt tttcctaata ctagagtata
    21361 acaatgccga taacagttcc tcttaataat agctttacta aactgtactt tcgttagaag
    21421 agagagaccc ttagacaaaa attatctaag ggaaaaatag cgtaacattt ttataaatct
    21481 tctttatttt tcgtatcact cagcgattta tgtaccctta tgcgatataa attaccaatt
    21541 atttccctgt atcatattca catatatgta aaatatcact tatatcaatt tccttaatat
    21601 aagacgattc gtaaacaagt tggggtataa tcatctttta atcatcataa cggtttctgc
    21661 ttaaactttt gatagttccg tacctttaac agaagtatac tgccacaatc tgtacaaata
    21721 taagcatcta ctggtgaaga tgtgaacatc gtctcctttt tccgtatttg tgcatatccg
    21781 acaaactcac cttctcctat gttatgagaa ccacaattag agcatgtctg cacggttttt
    21841 tgtttcatga gagcaccacc tttaatctgt ttccactccc ttcgacagct cacttccatt
    21901 tcccttccaa aaaacctctt attctctcac atttcaacag gaatctcaaa acaaaaatcg
    21961 tatatgtact atgaaatata tttattaacg gaggaatttt atgactactg ttattacact
    22021 cggtatagca acagaaattg aaaatgcaga aattgatatg ctctcttcta gattagagag
    22081 actacaaaca ataagcggaa acccaatgca agtgcaaatg aaaaaattcg gtagcgccac
    22141 tgccttttca tcaaaaataa ttgctggtcc tgcttttaat acggtaaaag gtattacaaa
    22201 tgcagatgcg attgatgcaa tcatttctta ttatgaatca ctacaaatcc cttgtcgttt
    22261 tgaaattaca ccagcacaag gtacaactga attatttcaa tacttatctc aaaaagggtt
    22321 ttatcaatct agcttccata ctgctttgta tagtataccg agagagggtt catcacttct
    22381 tccttctaat attacaatac gaaaactaaa agaaaatgag tttgatattt ttgcagacat
    22441 ttatgtacat ggatttaata tgccatcctt tacaaaagat agcatgcgcc aaaataatga
    22501 aattctttac aatgaaccag gatggcattt tttcatagct gaagttcaaa atatccctgc
    22561 tggtattggt gtcctgtata taaataaggg tgtcgcatca ttagctgctt ctgctacttt
    22621 gccagaattt cagcgtaaag gctgtcatac tgcattaatt caaaaacgaa ttaagacagc
    22681 tattgaatcc aattgtactt taatagttgg acaagcaagg ttcggtagcg gcagtcaaaa
    22741 taacatggaa cgtgcccaca tgaaaattgc ttatacaaaa tcaatatgga ccgcaaaaga
    22801 catataattt actttatttc tccttccgtt acatttttaa acattttatg acaaatcctt
    22861 ttctatccta ttaatcattt gaatattcaa actagatttg ttacgatatt actagataca
    22921 tcattcaact tgcaatatga aaagagaatt ctaatcaaac tacaaggagg agaaatgtat
    22981 gactaaacat gatcatggtt taaaagaaaa agtagaaggt gccattgata aggtaaaagg
    23041 tgaagtaaaa gaagttgttg ggaaagtaac tgacaataag aaattacaag ctgaaggaaa
    23101 atgggataag gtgaaaggca ctgctaaaga tacagttggt aatgtaaaag aaaaagtaca
    23161 tgaatataaa gaacacaaga aagaaaaata aaaaaagagc ccatcggctc tttttttatt
    23221 ttccttcatt cttctctagc acgtataaat cttcttccat attcgttaat ttctcactta
    23281 caagctttct tgcatctcca attgcttgat tatatgcaaa cggtccaact aatttaatca
    23341 tttcttctat taaacgctct gcttggaaac gcccaatttc atctaaatct tcttccataa
    23401 aaaattgctg aatttgtgct acaagttctt cttttttatc atttggtatt tttatattca
    23461 tcatcgttgt tactcctcta tatttaagat agtatcttcc ttaactctac catagaaaaa
    23521 cgattaccag gacagctttt tgtaactcct tctaactctc tatgaccgag tatattttct
    23581 ttctttatag caaattgctt cataaacagt ttacataaag aatataatgc attcacttgt
    23641 gcaggagttg gatcgtattt atcgaaattt cccgtcatac atattccaat tgtatggcgg
    23701 ttatggtctt tcgcgtgcgc tccaatatgt aaacctcgtc cttccactac agttccatcc
    23761 ttttcgataa aatagttgta accaattccg ctccaccccc ttacagtttg atgaaattca
    23821 tgcgttttat acacgtccca tccatcttca gctgtatggt gaataatcag tttgtttact
    23881 ttttctaaag gaactaattc atcttgaaat gttagattga cacgtttaat ttccatttga
    23941 actgcctcct cttaaaaatc aatcataata atcgttttat catctggcct tattctcttt
    24001 tccgcttcta gctcttcaat aattgctata tattcgttta tactattctt tcttatatat
    24061 gcaacagttt gttctaatga ccaatctggg tgaaataacc cgtctgaaca aataaaaatc
    24121 ccactcactt catctgtatg taattcacca tgttgtaaat aatgtatcgc ttctttcatt
    24181 ccatttgcaa ctgaataacc atttggcata tttgcaagat aacgattgta ttttaactgt
    24241 tctcgaacat cttgaaaaac atattcttct ggtacagata accctttttt acgatcttct
    24301 tccctcttct tttttgctct tttactaatt ccttcaactg tgtctttcgt taatacttgc
    24361 atcgttccat tttgaaaagt tgcgacaatc atacagtccc caagctgcgc atattcaatt
    24421 ttctcaccaa ctatttggac tgccgcgata catgtgcacc acaaatgctc tttttttctc
    24481 gtgtctactt catattctaa cattttgctt tgcaatgctt catttgcttt ggcaactgca
    24541 aattgtaaac tatgattctc tcgtaatgca gtaaaataac ttgcaaataa atgcgaagcg
    24601 atgtatgctc cattatgtcc cttttcatca cgaaacggga caagtggtgt tgcaccgtca
    24661 catacaccat aaatcttttt ttctttatta caaaaataag aatcctcaca ttcttgcttc
    24721 aacgggcttt tctgttgata tgtttttatc ttcacaactg tatccccttt caaatgataa
    24781 aatactcaaa ttcttttgat taatctaatt tacctaaata aactgttttt acccaaaact
    24841 ttcaatatca tatataatct tgaaataata tgaatttttc agtgaaggac gggaaagaaa
    24901 tggtcagatt ccttggtgtt attatcggtt ctattattat tgcggttgcc tttaatcttt
    24961 tccttatccc ccacaaaatt ttaagtagtg gaattggcgg aattgctatt attttaggga
    25021 ttgtaacccc tgtaaacaca ggcattatta actttgtatt aaacttacct atccttattt
    25081 tagggtacat aggtcttgga aaaaaagtaa tttttaacac agttgtctct gtagttgtat
    25141 tatctgttgc attatactac gttccagtaa aagtcgtagc aacagatcca ttgttatctt
    25201 ctatcttcgg aggtgtaatc gccggagctg gtattggtct tgtttttaac tgtaatggat
    25261 ccactggtgg atttgatatt atcggtatgc ttttatcccg caagcgagac attaaacttg
    25321 gcggattcct tattatttta aatgcagtcg ttgtaataat cgcaggattc ttcttcacct
    25381 gggatgttgc acttacaagc ttactttcaa tttatgtaac tggtaaagta attgatgctg
    25441 ttcatacaaa acatcgtaaa gttacactta tgattgtaac aaatgaagca gaaaaaatga
    25501 aaaaacaact tctttcaact gttgtacgtg gaataacgtt acttgatggc gaaggtgctt
    25561 attcaagcga gaaaaagcgt gtacttatga ccgtcgtttc tcgtgaagaa ttagcaagta
    25621 tgaaactaac aatttctgaa atcgacccga atgctttcgt taatattaca gaaactgtag
    25681 aagtgttagg acttttcaga agaagttaaa gactaggtgg gaatccacct agtctttatt
    25741 ttgcataaat tcaattcggt ttccaaatgg atctgacacg taaaatcgaa ttacatctgg
    25801 ccgtgcataa tcatcaatca ctttaacacc ttgctctata agtgtttgct taaattcatt
    25861 aatttcattc acataaaaag ctggatgagc ctttttagct ggtgtaaagt tccgctcgac
    25921 accaatatgg atttcttgat ttccgcattt aaaccaacat ccacctcgtt ttttcaactc
    25981 ttctggcttt ggaatttctt ccataccaat cgtattccca taaaaatcac gcgcctcttc
    26041 ttcacaccct acaggtgcag ctacttgcac gtgatcaatc ccttgaatat aatttttcat
    26101 tttctctccc cctcctctac cctaatgtta tacggaaaac agccgtctgt aacttacaaa
    26161 aggtttataa aacaatataa gctcccctta ttaccatcct gcattcacct tgcaaaaaat
    26221 aaaaaaaaca aaatttattc tataacttcc attttttata gaaatacaca ttacatctat
    26281 attatagtta tgaatagaca aatcttttta gatgctattt gtacggagga actattatga
    26341 gtcgtaaaaa atattcacca actcaaaaaa aacgtcatcc gaacatttct agacgtttgc
    26401 gaaaccatat acaagatcgt tcattaacag aaatgtacgc atct
//
