LOCUS       NC_022873              25239 bp    DNA     circular CON 15-AUG-2024
DEFINITION  Bacillus thuringiensis YBT-1518, complete sequence.
ACCESSION   NC_022873
VERSION     NC_022873.1
KEYWORDS    RefSeq.
SOURCE      Bacillus thuringiensis YBT-1518
  ORGANISM  Bacillus thuringiensis YBT-1518
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 6002284)
  AUTHORS   Wang,P., Zhang,C., Guo,M., Guo,S., Zhu,Y., Zheng,J., Zhu,L.,
            Ruan,L., Peng,D. and Sun,M.
  TITLE     Complete genome sequence of Bacillus thuringiensis YBT-1518, a
            typical strain with high toxicity to nematode
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6002284)
  AUTHORS   Wang,P., Zhang,C., Guo,M., Guo,S., Zhu,Y., Zheng,J., Zhu,L.,
            Ruan,L., Peng,D. and Sun,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAY-2013) State Key Laboratory of Agricultural
            Microbiology, College of Life Science and Technology, Huazhong
            Agricultural University, 1 Shizishan Road, Wuhan, Hubei 430070, P.
            R. China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 1.04
            Reference-guided Assembly         :: NC_005957.1
            Genome Coverage                   :: 190X
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497525.1-RS_2024_08_15
            Annotation Date                   :: 08/15/2024 02:37:33
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,968
            CDSs (total)                      :: 6,823
            Genes (coding)                    :: 6,362
            CDSs (with protein)               :: 6,362
            Genes (RNA)                       :: 145
            rRNAs                             :: 15, 15, 15 (5S, 16S, 23S)
            complete rRNAs                    :: 15, 15, 15 (5S, 16S, 23S)
            tRNAs                             :: 95
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 461
            CDSs (without protein)            :: 461
            Pseudo Genes (ambiguous residues) :: 0 of 461
            Pseudo Genes (frameshifted)       :: 191 of 461
            Pseudo Genes (incomplete)         :: 266 of 461
            Pseudo Genes (internal stop)      :: 128 of 461
            Pseudo Genes (multiple problems)  :: 100 of 461
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:11:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2772148
            Orig. end                         :: 2797387
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP005935.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="7"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            296..1222
                     /gene="bla"
                     /locus_tag="YBT1518_RS13960"
                     /old_locus_tag="YBT1518_13965"
     CDS             296..1222
                     /EC_number="3.5.2.6"
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="YBT1518_RS13960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13965"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_043924791.1"
                     /transl_table=11
                     /translation="MILKNKRMLKIGICVGILGLSITSLEAFTGGALQVEAKEKTGQVK
                     HKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIATLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRQMGDRITMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RKILTEWMKGNTTGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPIIIAIL
                     SSKDEKEASYDNQLIAEATEVIVKALR"
     gene            1483..2325
                     /locus_tag="YBT1518_RS13965"
                     /old_locus_tag="YBT1518_13970"
     CDS             1483..2325
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="YBT1518_RS13965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13970"
                     /product="metallophosphoesterase"
                     /protein_id="WP_000727180.1"
                     /sec_met_domain="Metallophos_2 (E-value: 2.8e-07, bitscore:
                     29.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICILVGFTIFLYLQNNLISITEIKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKMKSIDPDIIAITGDLIDSKSYDAEVSMQLIREM
                     VKKYPVYFVTGNHEQWSGKYNSLEKELKKYGVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     GTGNRDEGNIIIDEIKKAKIEMQPDRYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYVEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            2540..2791
                     /locus_tag="YBT1518_RS13970"
                     /old_locus_tag="YBT1518_13975"
     CDS             2540..2791
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="YBT1518_RS13970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13975"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            2979..3704
                     /locus_tag="YBT1518_RS13975"
                     /old_locus_tag="YBT1518_13980"
     CDS             2979..3704
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="YBT1518_RS13975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13980"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023522003.1"
                     /transl_table=11
                     /translation="MQQPSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNINMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKTRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVSS"
     gene            3701..4720
                     /locus_tag="YBT1518_RS13980"
                     /old_locus_tag="YBT1518_13985"
     CDS             3701..4720
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="YBT1518_RS13980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13985"
                     /product="ABC transporter permease"
                     /protein_id="WP_006928521.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKNQEASIYEYSKENAISELEKQKVDAILRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            4745..5398
                     /locus_tag="YBT1518_RS13985"
                     /old_locus_tag="YBT1518_13990"
                     /pseudo=""
     CDS             4745..5398
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168191.1"
                     /locus_tag="YBT1518_RS13985"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13990"
                     /product="TetR/AcrR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKKNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYERLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKF"
     gene            complement(5520..5819)
                     /locus_tag="YBT1518_RS13990"
                     /old_locus_tag="YBT1518_13995"
     CDS             complement(5520..5819)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="YBT1518_RS13990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_13995"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728157.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSTQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDKNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            6053..7021
                     /locus_tag="YBT1518_RS13995"
                     /old_locus_tag="YBT1518_14000"
     CDS             6053..7021
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="YBT1518_RS13995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14000"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_023522005.1"
                     /transl_table=11
                     /translation="MRQFAKTTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTEKMEQFSNDFLQTIPDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGSGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHSKNIKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNEKIEVVFE
                     NYEKTLYELFMRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7238..8383
                     /locus_tag="YBT1518_RS14000"
                     /old_locus_tag="YBT1518_14005"
     CDS             7238..8383
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="YBT1518_RS14000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14005"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397279.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.2e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.3e-57, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8399..9736
                     /locus_tag="YBT1518_RS14005"
                     /old_locus_tag="YBT1518_14010"
     CDS             8399..9736
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="YBT1518_RS14005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14010"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486742.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 3e-10, bitscore:
                     38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 4e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3.3e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 5.3e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="YBT1518_RS14010"
                     /old_locus_tag="YBT1518_14015"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="YBT1518_RS14010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14015"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="YBT1518_RS14015"
                     /old_locus_tag="YBT1518_14020"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="YBT1518_RS14015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14020"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775436.1"
                     /sec_met_domain="HMGL-like (E-value: 1.9e-47, bitscore:
                     160.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISVTAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="YBT1518_RS14020"
                     /old_locus_tag="YBT1518_14025"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 3.3e-74. Score:
                     241.2. Matches aSDomain:
                     nrpspksdomains_YBT1518_RS14020_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="YBT1518_RS14020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14025"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_023522006.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLEELQNILTQI
                     SEESNTRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGVQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPTYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YBT1518_RS14020_ECH.1"
                     /evalue="3.30E-74"
                     /label="YBT1518_RS14020_ECH.1"
                     /locus_tag="YBT1518_RS14020"
                     /protein_end="254"
                     /protein_start="14"
                     /score="241.2"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLEELQNILTQISEESNTRVVILTGA
                     GEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGVQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="YBT1518_RS14025"
                     /old_locus_tag="YBT1518_14030"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="YBT1518_RS14025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14030"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886744.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="YBT1518_RS14030"
                     /old_locus_tag="YBT1518_14035"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 3.9e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_YBT1518_RS14030_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="YBT1518_RS14030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14035"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806481.1"
                     /sec_met_domain="AMP-binding (E-value: 8.1e-88, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13596..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_YBT1518_RS14030_AMP-binding.1"
                     /evalue="3.90E-82"
                     /label="YBT1518_RS14030_AMP-binding.1"
                     /locus_tag="YBT1518_RS14030"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YBT1518_RS14030_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="YBT1518_RS14030"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_YBT1518_RS14030_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="YBT1518_RS14030"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            15574..15789
                     /locus_tag="YBT1518_RS38200"
     CDS             15574..15789
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="YBT1518_RS38200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_000236251.1"
                     /transl_table=11
                     /translation="MVIMTLAIVPGESRSEAVTVTVPGPLAARNTAVKLPEALVMTARG
                     TMKARDGLLNEKLTTTPGVGLPFTNT"
     misc_feature    15809..15826
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            15835..16056
                     /locus_tag="YBT1518_RS38205"
     CDS             15835..16056
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="YBT1518_RS38205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_241752517.1"
                     /transl_table=11
                     /translation="MVSLEVKVIDAGPAGRLNPVGPVDPVGPVNPVSPVNPVGPVDPVN
                     PVDPVGPVGPVDPVNPVAPVEPVGPVGN"
     gene            complement(<16074..16130)
                     /locus_tag="YBT1518_RS38920"
                     /pseudo=""
     CDS             complement(<16074..16130)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="YBT1518_RS38920"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDKFLSFAALNPGSIGPTL"
     gene            complement(16328..16696)
                     /locus_tag="YBT1518_RS14040"
                     /old_locus_tag="YBT1518_14050"
     CDS             complement(16328..16696)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="YBT1518_RS14040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14050"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_000526886.1"
                     /transl_table=11
                     /translation="MGNIPKVSSHQSNPNIPSQQVNPNTQQGSIKKTRRRIITTLAFIL
                     PIIFVLQYSLNNQQEMIKEKQITLNTEQQKLSSVKKDGHSLNKDVKALTSSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            complement(17088..17498)
                     /locus_tag="YBT1518_RS14045"
     CDS             complement(17088..17498)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="YBT1518_RS14045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_175056335.1"
                     /transl_table=11
                     /translation="MKGGRNKCPGKMIAGVLRKSIVVMIGGNLKKSIIVMIIGVLRKSI
                     VMMIGGNLKKSVIVMTIGVLRKNIVMMIGGNLKKSVIVMMIGVLNEISVVVNVSLFVAI
                     VKEKIGNIFNVNVKERICLLEPINTRMYYTKS"
     gene            18062..18418
                     /locus_tag="YBT1518_RS14050"
                     /old_locus_tag="YBT1518_14055"
     CDS             18062..18418
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="YBT1518_RS14050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14055"
                     /product="hypothetical protein"
                     /protein_id="WP_000535577.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDVVRLAAIPGSVGVIISICKIEAIFPPVTTVT
                     ADFDFNGIDVANKA"
     misc_feature    18433..18448
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            18524..19057
                     /locus_tag="YBT1518_RS14055"
                     /old_locus_tag="YBT1518_14060"
     CDS             18524..19057
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002163646.1"
                     /locus_tag="YBT1518_RS14055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14060"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_000990082.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLESFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTLAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDELKLHRVTLGVYDFNTSAISCYEKIGFVKEGLLRESKRVGETYW
                     NLWEMSMLEYEWKK"
     gene            19103..19672
                     /locus_tag="YBT1518_RS14060"
                     /old_locus_tag="YBT1518_14065"
     CDS             19103..19672
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000513267.1"
                     /locus_tag="YBT1518_RS14060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14065"
                     /product="hypothetical protein"
                     /protein_id="WP_370451638.1"
                     /transl_table=11
                     /translation="MGIVDNKTKIISIAAVSGGGKTTITERLKHKFKNSKALYFDSYTF
                     DNSPADICKWIDDGANYDEWVLTPLIHDIEQLIQNNILDYIIVDYPFAYLNSEMRKFID
                     VTIFIDTPLDIAMARRILRDFKEGTIDEIHNDLEHYMTYARKAYLEAIHTVKPNSDIIL
                     DGSLSVSEIINHAVEELGRREVIVNG"
     gene            19724..>19959
                     /locus_tag="YBT1518_RS34935"
                     /pseudo=""
     CDS             19724..>19959
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="YBT1518_RS34935"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYTLFQYNWQVRDDWFKWCEQLSEEDLLCKLGVC"
     gene            20835..22109
                     /gene="ltrA"
                     /locus_tag="YBT1518_RS14065"
                     /old_locus_tag="YBT1518_14070"
     CDS             20835..22109
                     /EC_number="2.7.7.49"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ltrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000421374.1"
                     /locus_tag="YBT1518_RS14065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14070"
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="WP_023520826.1"
                     /transl_table=11
                     /translation="MELLETILSNQNMNEAYLRVYKNKGASGVDGVTVDELKQYLKENK
                     DELRQRIRTRKYQPQAALRVEIPKENGKMRKLGIPTVVDRVVQQAIHQILSPIFEKQFS
                     EFSYGFRPKRSCEMAIVKSLEFLNAGYEWIVDIDLERFFDTVHHDKLMRIISNTISDGD
                     VISLIRKYLVSGVMVNGKYEETSVGTPQGGNLSPLLSNIMLNELDKELESRELQFVRYA
                     DDALIFVKSEKAASRVMKSIVRFIEKNLGLIVNTEKSKISRPEDLKFLGFGYYYNSKDE
                     RYQTKPHPISVQKLQRKLRQLTKRNWSVPLDYRILKLKQVIFGWVNYFRITNMKGVMKQ
                     VDKKLRSRIRVIIWKQWKIPKKQIKSLVQLGIPEEEAKGLTYCRKGYRYIGLSKVVQRA
                     MSNQRLKKRGVPSSLERYLKVRTAI"
     gene            complement(22198..22335)
                     /locus_tag="YBT1518_RS34940"
                     /old_locus_tag="YBT1518_14075"
     CDS             complement(22198..22335)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="YBT1518_RS34940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14075"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     misc_feature    complement(22488..22497)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            <22501..22611
                     /locus_tag="YBT1518_RS36680"
                     /pseudo=""
     CDS             <22501..22611
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288863.1"
                     /locus_tag="YBT1518_RS36680"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DNA damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVI"
     gene            complement(22672..23688)
                     /locus_tag="YBT1518_RS14070"
                     /old_locus_tag="YBT1518_14080"
     CDS             complement(22672..23688)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="YBT1518_RS14070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14080"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_023522009.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSATLSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTVLMNKKAKELKLLQPSPFLNS
                     TGINHDTNKQSTTTAIDAAKLAARLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSYSALQAFKDALTSWTILLQFKNLIIQTIMIFLIITTLMFLHIRQKKSEDFN"
     gene            complement(23864..25021)
                     /locus_tag="YBT1518_RS14075"
                     /old_locus_tag="YBT1518_14085"
     CDS             complement(23864..25021)
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="YBT1518_RS14075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="YBT1518_14085"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_001243312.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
ORIGIN
        1 tgtatatttt gatttaaaac agcaacgtat acatggtgaa tctactagta cagatagttc
       61 taagcaaaat tagagtaatt ttctcaggga atagaccctg tttatataaa gccatttata
      121 agtaaaaaaa tgaaatgtga aataagagat agcggcgatc atagctacta tctcttattt
      181 tgttaataac tctcatacta gctataaaat ttttttcagt ttatggaaca aatttggttc
      241 ggtgattgtc tattatgtgt acgtataaaa aggtgctaaa aatttggaag gaatgatgat
      301 tttgaaaaat aagaggatgc taaaaatagg aatatgcgtt ggtatattag gtttaagtat
      361 tacaagtcta gaagctttta caggaggggc actgcaagtt gaagcgaaag aaaagactgg
      421 acaagtgaaa cataaaaatc aggcgacgca taaagagttc tctcaacttg agaaaaaatt
      481 tgatgctcga ttaggtgtat atgcgattga tactggtaca aatcaaacaa tctcttatcg
      541 atctaacgaa agatttgcct tcgcatcaac ctacaaggct ttagccgcag gagtattact
      601 acagcaaaac tcaattgcta cattaaatga agtaatcaca tttacgaaag aagacttagt
      661 ggattattca cctgttacag agaaacatgt agatactgga atgaaactag gagaaattgc
      721 tgaggctgct gttcgttcaa gtgataatac tgcagggaac attttattta ataaaatagg
      781 cggacctaaa ggatatgaaa aagcgcttag gcaaatgggg gatcggatca ctatgtctga
      841 tcgctttgaa acagaattaa acgaagctat tccaggagac attcgtgaca ctagtacagc
      901 gaaagcaatt gctacgaatc ttaaagcttt tacggtcgga aatgcacttc cagctgaaaa
      961 acgtaaaatt cttacagagt ggatgaaagg aaatactaca ggggacaaac ttattcgggc
     1021 aggcgtacca actgactggg tagttggaga taaatcaggt gctggcagtt acgggacaag
     1081 aaatgatatt gctattgttt ggcctccgaa tagagcacca attatcatcg caattttatc
     1141 tagtaaagat gagaaagagg ctagctatga taatcaactc attgcagagg caactgaagt
     1201 tatagttaag gctcttaggt aatagtattt tagttttcgc atttttaaca tgaaagtatt
     1261 aaaagtataa agttagaaaa cgactctttt cgtgtgataa gagtcgtttt tgtattctta
     1321 ttattaaaaa ggtaaaagta aaaatataac gaatatatat gacatatctc atatgaaatt
     1381 tcatgtactg tattatttta ttaatttaaa taaatttcaa gaaagtataa tataattcag
     1441 ttagcatata gaagtgtttg atgagaatgt aaaggagaaa atatgaaaaa gaagattaat
     1501 agaattgtaa tgattatttg tatattagta ggttttacaa tctttttata tttacagaac
     1561 aatttaataa gtataactga gattaaaata acctctagta aaataccatc ctcttttaaa
     1621 gggtataaaa ttctacaaat ttcagactta cacaataaaa aatttggcga taatcaagat
     1681 gtgttaattc aaaaaatgaa aagtatagac ccagatatta ttgcaattac gggtgattta
     1741 attgacagta aatcatacga tgcagaagtt agtatgcaat taatacgaga aatggtaaag
     1801 aagtatcctg tatattttgt gacaggaaac catgaacaat ggtctggaaa gtataacagt
     1861 ttagaaaaag agttgaagaa atatggtgtc aatgttttaa ggaatgaaca tgtaggcatt
     1921 cgaaagggtg agcaagagat aaacttgcta ggtattgatg atccagagtt tggtactgga
     1981 aaccgtgatg aaggaaatat tataatagat gaaattaaaa aagcaaaaat tgaaatgcag
     2041 ccagatagat ataatgtatt attatcccac aggcctgaat ttataaagga atatacgaat
     2101 gagaggttgg atttggtttt atcgggacat gctcatggag ggcaagttag attgccattt
     2161 atcggtggat tagttgctcc aaatcaaggt attttaccta aatatacagc aggtttatat
     2221 gtagaacaaa atacatcaat ggtagtgagt agaggattag gaaatagtat cattccgcaa
     2281 agaattttga ataggccaga gattgtagtc gtgcagctaa attaagttgt acgatttttt
     2341 tatacaataa tgagtaaagg tgttttatgt attttgcagg agttaacatt acaattttgt
     2401 taaaaatttt ctacgttaca taaagtaaca aaatttgacc ctgattgttt gttatagtgt
     2461 aaataatcaa aaaacttaaa atttgtcgag tgaaaattgt gataagtaat tcatgtaaaa
     2521 aacttaaagg ggtgtacaca tgcataaaga atatgaaatt gaagaataca cagcgattga
     2581 ggaacaaata cattattatt gtaaatgttt attagtaagt catcctgatc aaataataaa
     2641 gtatttagaa aaaaggttag aaaaatatgc agaaacatta caatatgcac acttatatcc
     2701 tgacacagtt attttaccgt tacagcaatt agttattgaa tattctttag atgttgctag
     2761 aattcggaag tatatgaatt taaaaacgta aagtgaaatt tatagtttaa atgaaacaga
     2821 gtcgacatta ggaaatgaaa tgctaatgtc gactctgttt cattgttcca tatcgttgct
     2881 tgaacataca tactaatcaa tgaagtttga catataatta agcaagggta aaataaaagt
     2941 gagtactcac tcattttatt ggaaaaggag gatgaaacgt gcaacaacct tcaattattt
     3001 tacggactgt atcaaaaagt tttgggaaaa aagaagtgtt acacaatctt tcattgcaag
     3061 ttgaaaaagc agaaattttt ggttttgttg gaccttctgg atcggggaaa acaacgctca
     3121 ttaaaatgat tgcaggtatt aatgaggcga cgaaaggtga agtgcttgtt aataatatta
     3181 atatgcctaa tttaaatgaa atgaaaagaa ttggttatat ggcccaggcg gatgcattat
     3241 acgaagaatt gtcagcgtat gaaaatgcag attttatagc aacgatgtat ggactaaagg
     3301 gaaaacgtaa aaagacaaga attgcagagg tttttgaact tgtacaattg tcacagtata
     3361 tgaaaaagca agtacaacaa ttttcaggtg gaatgaaaaa acgcttatca ttagcaatag
     3421 cgctccttca cgaaccagaa atattaattt tagatgagcc tacagtgggg atagatccgc
     3481 ttcttagaaa aacgatttgg gaaaaatttt atgatcttaa aaagaaaggc acaacgatta
     3541 ttgtaacgac gcacattatg gatgaagctg aattttgtga gcgtctaggg ttaattagag
     3601 aagggaaact agttgcggtt ggaacaactg aagaattgaa aaaacgcgtg tcatctggac
     3661 ggattgaaga tgtctttttg ttggaagagg tggtgtcatc atgagagtta ctggtgtaat
     3721 cattcgtatt attcgccaat tttttcgaga taagcgttcg ttagcgatga tgtttggggc
     3781 accaatgtta ttactttggc tattatcgct agtgtttaca caaaaagact atataccgca
     3841 aattgctgtt gttgatatgc ccgctcaaat agtaaaagtg atgaaaaatc aagaagcgtc
     3901 aatttatgaa tacagtaaag aaaacgcgat ttctgagtta gaaaaacaaa aggtagatgc
     3961 aatacttcga atagagaatg gaaaaatgaa acttctgttg gaaggtagtg attcgtcaaa
     4021 aaatcgtgct gtacttcaag tattgcaaaa aagcacagag aagaatgatg tatcgattat
     4081 gaaacctgaa gtaaattatt tacatggctc taaagacttt acgatgtttg atgggcttgg
     4141 tcctgtatta attggtttct ttacattttt ctttgtattt atattatcag gtgtatcttt
     4201 cgtaagagaa cgtttaagtg gtacgctaga aaggttatta tccaccccag taagaagatg
     4261 ggaaatagtc gcaggttata ttattggttt tggaatcttt gcctttatac aatccattat
     4321 tatcgtaagt ttttccgttt atattttaga tttatacgta gctggctcca tatggctaac
     4381 gttacttatt acatgtatgc tctctttaac tgcactaaca ttaggtacgt ttttatcggc
     4441 atacgcaaat aatgaatttc aaatgattca atttataccg cttgttattg tgccacaaat
     4501 cttcttttct ggattgtttc caatggaatc tatgaataag tggctacaaa tgttagggaa
     4561 agtatttcca ctcacatacg gcgctgacgc aatgagacaa gtgatgattc ggaatcaagg
     4621 gtttacagag attgcattag atcttactgt attattactt ttttcactat tatttgcagt
     4681 aggaaatgta tttgctttaa agaaacatcg caaaatataa taatgacaaa aaggagcttt
     4741 ataaatgcag aaggattggc tggaggaatt aatagctgca actaatacgg ataaaaaaaa
     4801 tgaacgtcaa atgcgaatat tagaggcggc tgttgatatg tttggagaaa aaggatacgc
     4861 ttcaacttca acaagtgaaa ttgcaaaacg ggctggtgta gcggaaggaa caatcttccg
     4921 ctactataag acgaaaaaag atttattact agcggtcgta atgccaactt taactaagtt
     4981 cgctgcacca tttttcgtac aaacctttgc aaaagaaata tttaaatcgg agtatgaatc
     5041 atatgaaaga cttttaaggg ttgtaattca taataggttt aaatttgctc aaaaacactt
     5101 tcctatgata aaaatattaa ttcaagaggt gccattccaa ccagaactga aaaatgaaat
     5161 acagcaatta gtagaaacag aactgttttc acatttcaaa aagttgattg tgaaatttta
     5221 agaagaaggg gaaattattg agataccacc atcttccgta ctacgtctta ctttatcagc
     5281 tgtattaggt ttattattaa cacgattttt attattgcct gaagaaaaat ggaatgatga
     5341 agcggaaatt gaaaatacga ttcaatttat attgtatgga ttaactccac gattttaatc
     5401 gttgaagtgt gaattacata cattactttt aagtaaaaat aaatcgcctt taaaaaggcg
     5461 atttattttc attatatatt tttgataaat aagtacttgt ttactaaaaa cattctaaat
     5521 cagcgtgttt ctttgtctct tcttctaaga cctaataatc ctgctagtcc taataaacca
     5581 agccaagccc aattattatt tttatcacga ttatcattta aatcatttgt tgtatttaca
     5641 tttcgagttc ttacatcatt attaactctg tctaagttat tgtcatttac tcgagttgaa
     5701 atatcagtgt tattaactct attcatatta tttccatcgt attcagcttg cgtagatgta
     5761 cctaaaaaca taatagatag tgctaaaaca cttaaaatag atgataattt ctttttcata
     5821 acaatccctc ctttcttaat cattaatttc tccgaagcaa gtgtgtatta ttcatttcac
     5881 aatatctaaa ccctcattaa taaggcgcac atttatagaa aatagagttg aatgattgtt
     5941 aatatatcat tggatatata tttctcataa aaataaatga atcaaacttt gcttaaaatg
     6001 ttaatcttag tacaatttat attatacggg ctagcactaa ggaggtaata agatgcgaca
     6061 atttgcaaaa acaacaatcg tcgtaagtaa atgtttagaa tttgatgctt gtcgttataa
     6121 tggagagatg attccagatg taacaatacg aaatttgcag ccatttgtta catttatacc
     6181 tgtttgtcca gaagtcgaga ttggattggg gactcctcgt gaaacgatac gaattgtaga
     6241 agaaaatggt gagaatagac ttgtgcaacc gtcgacacga gaagatgtaa ctgaaaaaat
     6301 ggagcagttt tcaaatgact ttttacaaac gataccggat gtggatggtt ttattttaaa
     6361 gaatcgttca ccaagttgtg gtacgcgtga tgtgaaaatt tattctggtt ttgaaaaagc
     6421 gccagcaaag ggaaaaggat cgggcttatt tggcggagca gtagtaaaaa aattttcgca
     6481 tcttcctatt gaagaggaag gcagattgtc gaattttatt attagagagc atttctttac
     6541 aaggctattt acaatcgcat attacaaaat gattaaacat agtaaaaata taaaagacct
     6601 tgtatcgttt cagtcggaca ataaatattt atttatggca tataatcagg tgaaacaaaa
     6661 ggaattaggg cgtataattg caaatcaaaa aaatgaaaag attgaagtgg tatttgaaaa
     6721 ctatgagaag actttatatg aattatttat gcgtgcgccc cgttatacat cgaatgtaaa
     6781 tgtatgcgag cacatttttg gatattttaa aacaaagtta aaaaaacaag aaaaagatca
     6841 ttttatagaa ctgttacaaa agtatgcaga aaagaaaata ccacttagta gtttacttac
     6901 aattttaaaa tcatgggcta ttcgatttga tgaaaagtat ttattaagac aaacatattt
     6961 cgaaccatac cctgaagcat tagtagaaat ttctgattcc ggaaaaggta gagattatta
     7021 aacaataaat tacataattc gacacaaaac ctcctatgtt gttgtagaac aatgtaggaa
     7081 tttttttgtg cattagtaca gaatctgttt taaaattaag ttatgacaga attgtagcaa
     7141 ttgtctaact aatattcttg tctttaaagt tgttatgttt gtagtagaaa ctcgcacgct
     7201 gtcgaaactc aatattcgat aaggggtgtg tagcggaatg gaatttactc taactcgcga
     7261 aaaacaaatg attaaagaaa tggtacgtga ctttgctgaa aaggaaatcg caccgaaagc
     7321 tgtatattat gacaaaactg cagagtttcc atatgaaaca tttcaaaaaa tgggcgaact
     7381 aggattatta ggcatcccat tcccagaaga gtatggaggt tcaggtggcg atacggtatc
     7441 gtatgcgtta gcagttgaag aaattggtcg cgcttgtggt ggcaccggtt taagctatgc
     7501 tgcaacaatt tcattaggtg cttctccaat ttattatttc ggtacagaag aacaaaaaca
     7561 aaagtattta gttccaatgg cgtcaggtaa aacattaggt gccttcggat taacggagcc
     7621 gaatgctggg tcagatgcag gtggtactca aacgaaagcg gtattagatg gtgatgagta
     7681 tgtaatcagt ggtgagaagt gttggattac aaacgcagag tatgcaaata caattattgt
     7741 aaccgctgtc aacggtattg aagagaatgg tagaaaacgt atttctgcat ttatcgtgcc
     7801 tactacgagt gaaggattaa cgatttcaag tccttacgat aagatgggtg ttcgcgcttc
     7861 taatacttgt gaaatcgtac ttgatggtgt tcgtgtaccg aaagaaaata ttcttggtga
     7921 tgtaaataaa ggctttaaac aatttttata tacacttgat ggagggcgta tttcaatcgc
     7981 tgcattggca gttggtattg cgcaatcagc ctttgaacgt gcattacaat atgcgaaaga
     8041 acgtcaacaa tttggaaagt caatctctaa tttccaagcg attcaattta aattagctga
     8101 tatggcgact gaagtagagc tagcacgcaa tttagtacat aaagcagctt ggttaaaaga
     8161 taacgataaa cctttcggca aagaagcggc aatggcaaaa ctatttgcat cggaagcagc
     8221 aagccgtatt gcgaatcaag cagtacagat tcatggtgga tatggttata tgcgtgaata
     8281 tgaagttgaa cgacatattc gtgatgcgaa actattagaa attggtgaag gaacttctga
     8341 aattcaacgt ctcgtaattg ctagacattt aggatgtaga taaaagggag gaatcactat
     8401 gtttcaaaaa atattaattg cgaatcgcgg ggaaattgct gttcgtatta tgaaaacttg
     8461 tcaaaaactt ggcatacgca ctgttgctat ttattctgaa gcagatgaaa atgcccttca
     8521 tgtgaagatg gcaaatgaag cttacttagt aggtggaccg cgtgttcaag aaagttattt
     8581 aaaccttgaa aaaattattg aaatagctaa gaagacaaat gcagaagcga ttcatccggg
     8641 ttatggttta ttatcagaga atccgtcttt tccggttcgt tgcaaagaag aaggaatcgt
     8701 atttatcggt ccttcagaag aaatcattac gaagatggga agtaaaatcg aatcacgtat
     8761 cgcaatgcaa gcagcagatg tcccagtagt cccaggtatt actacaaata ttgaaactgc
     8821 tgaagaagca attgaaattg caaaacaaat tggttatccc ttaatgctta aggcatccgc
     8881 aggcggcgga ggcattggta tgcagttgat ggaaactgag caaacgctca ccaaagcgtt
     8941 tgaaagtaat aaaacaagag cgcaaaactt ctttggtaac ggagaaatgt atttagagcg
     9001 atatatagca gatgcgcatc atattgaaat tcagctttta gcagatacac atggtaacac
     9061 agtgtattta tgggagcgtg aatgttcggt acagcgccga aatcaaaaag taatcgaaga
     9121 agcaccttca ccatttttag atgaaggtac acgaaaggcg atgggagaag ttgctgtaca
     9181 agctgccaaa gcacttggct atacaaatgc aggtacagtt gagtttcttg tagatgatca
     9241 gaagaacttc tatttcttag agatgaatac gagattacaa gtagagcatc cagtgacaga
     9301 agaaattacg ggattagacc ttgtagaaca gcaactcctt atcgcaagtg gagagaaact
     9361 atcatttact caggatgatg taaaacgtag tggtcatgcc attgaagctc gtatttatgc
     9421 agaggatccg aaaacattct tcccatcacc tgggaaaatt acagatttaa cattaccgtc
     9481 aaatgtacgg attgatcact tcttagaaaa tcatgtaacg attacacctt tctatgatcc
     9541 aatgattgcg aaagtcattg cacatggcga gactcgtgaa gaagcaattt cgaaattaca
     9601 tgatgctcta gaagaattaa aagtagaagg tattaaaacg aacacgccaa tgctactgca
     9661 agttttggaa gacgaagtgt tcaaagaggg tatttataca acggggtttg taacgaaaca
     9721 actcgttaaa aaataagatt taacaatatt aagggggaaa aaaatgatga cgaaagtata
     9781 cgcatcgatg gcaggaaacg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agccggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attattagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtaggac cacgtgatgg tttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagca ggattgtcgt atgttgaagt
    10141 ttcctcattc gttcacccaa aatgggtccc agcattagcg gatgcaaatg atgtgttttc
    10201 tgagctgaaa agggatccaa atgttacata tgctgcgctt gttccgaacc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcaat taaagaagca ttagttgtaa tcgaagatat
    10381 aacaaaacag gcattattcg aagggaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgtcac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctcttgg ggatacaatc ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgccatgca
    10621 ttttcataat acgtatggaa tggctctagc aaatgtagtt aaatcattag aatacggtat
    10681 tacaacattt gatagttctt gtggtggact cgggggctgc ccttatgcac caggagcatc
    10741 aggtaatgtt gctactgatg acctagtaca tatgctccat aaattaggag ttcaaacgaa
    10801 tatagacgaa gaaaagttat tgcgagctag tcaatttatt caaagtaagc taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgattatg taacacctca cgttgtaaag atttcgttat
    10981 atcgtgaaag acaagcaaac tcattatctt tagcgttatt agaagagtta caaaacatat
    11041 taactcaaat aagtgaagag tccaatacgc gtgtagttat tctaacaggt gctggtgaaa
    11101 aagcattttg tgctggtgct gatttaaaag aacgtgctgg tatgaatgag gaacaagttc
    11161 gccatgctgt tagtatgatt cgcacgacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaatgga atcgcacttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgctgctgaa tctgcaagtc ttggtcttac tgaaacgaca cttgcaatta
    11341 taccaggagc gggtggtaca cagcgcttac cgagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggtaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctaat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg acctattgct gttcgattag caaaagaggc aatttcaaat ggtgttcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatagatt agaaggatta caagcattca aggaaaaacg cacaccaacg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc taattcattt gaagaacgag ttgaaacgat
    11761 taaacaaggc ggcgcaccaa agtatcatga acaaaataaa gcaaaaggaa aattatttgt
    11821 tcgagatcgt ttagcgcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 taactgtgaa caaacaggct tacctgcgga cggcgttgta acggcaacgg gtaaaataca
    11941 tggtcgtact gcgtgtgtaa tggccaatga ttctactgta aaagctggat catggggatc
    12001 acgcacagtt gaaaagattt tacgtattca agaaacagct gaaaaactac gtgttccgtt
    12061 attttattta gttgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgtggt gcaggaagaa tcttctataa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgctta ttatttggac cttctgcagc tggtggtgcc tatattccag ccttttgcga
    12241 cgttgtaatg atggtagaag gaaatgcatc tatgtattta ggatctcctc gtatggctga
    12301 gatggttatc ggtgagaagg taactttaga agagatgggc ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa gacagaagaa gatgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagaaaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttcattct atgaagtgaa
    12601 aaaattattt gctcaagagc taattacagg cttagcacgt attgatggta agccagttgg
    12661 tattattgca aatcagccgc gtatgaaggg cggcgtatta ttccacgatt cagctgataa
    12721 agctgctaag tttattaatt tatgcgatgc atatcatatt ccattattat tccttgcgga
    12781 tgtaccagga tttatgattg gtacaaaagt agagcgtgcc ggtattattc gccacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaag atttctatcg ttgttcgtaa
    12901 agcatatggt gctggtttat atgcgatggc aggtccagca tttgaaccag attgctgcct
    12961 ggcattaccg acagcctcta ttgcggtaat gggtccagaa gctgcggtta atgctgtata
    13021 tgcaaataaa attgcagctt taccagaaga agagcgtgct agcttcattg ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatattta tcatttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaagga cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gttaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtacaaggaa aaaacacgtt tatatggttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agtaggctat caatggatga aaccttatac agaagtgtta gacttagaaa
    13501 atggtacacc gtttgcacag tggtataatg gcggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gcttgcggat gaagagacga gaatacagcc agcacttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga caactgggta agccgtgttg
    13681 cgaatggttt gaaacacgcg ggtattgaga aaggtgatcg tgtaacaatt tatatgccga
    13741 tgattccaga aacagttgtt gcgatgctag ctgtaatgaa aatcggagca attatttcac
    13801 caatattctc aggctttgcg tctgatgcag tcatgacacg tgtgcaagcg gcaggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgaggtaa aattgtttct ttaaaagatg
    13921 aagtagataa agcttgtgaa cattgcccaa ctgttgaaaa agttgttatc gttcgtcatg
    13981 caggaaatga ttttacacca cataactatg acttttcgtg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgag gaaatgcaaa gtgatgatcc attaatgctc atttatacat
    14101 caggaacgac tggtaagccg aaaggaacag tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ttggatgatg gggccatttt tattattcgg ttcactcatt aatggagcaa
    14281 cgatggttat gtacgaaggt gttccagact tcccagaagc agaccggtta tgggagacag
    14341 ttgataaata tgaaattact catctaggta tttcgccaac gttaatccga gcattaatgg
    14401 caaaaggtga tgagtatgtc aataaacatt ctttaaagag tttggaagta ttcgcatcaa
    14461 caggagaacc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 atgttccaat ctgtaactac tcaggtggaa ctgaaatctc tggtgggatt ttcggtaatg
    14581 ttcttattaa gccaatcgca ccgattagtt ttaacgcatc tttaccagga atggcagctg
    14641 tcgtactgga tgatcaaggt aaaccaattc gagatgaagt cggagaatta tgcttagaga
    14701 aaccttgggt aggtatgacg aaaagcttct gggaagatga tgaacgttac gtgaacacat
    14761 attggtcgcg ttttgaaaat aaatgggtcc acggtgactg ggtcatttac gatggtgaac
    14821 aatatatcat cacagggcgt tcagacgata cgttaaatat tgcaggtaaa cgtattggac
    14881 ctgctgaata tgaatctatt cttgtgaaac ataacgatgt aatcgaagct gctgcaattg
    14941 gtgtacctga cgaagtaaaa ggtgaagttt gtcattgttt tgtagtgtta agagaccatg
    15001 taacattcac aggagaatta aagaaagaat taatgagttt agtaaactct catattggaa
    15061 aagcgttgtg tcctaaagac atccacgttg tagaagattt accgaaaaca cgtaactcta
    15121 aagtaatgcg ccgtgttatt aaagcagctt acttaggaaa agagttaggt gatttatcat
    15181 cgcttgtaaa tcctgaagta gttccgttta ttcaggggtt acagtctagt aaattataaa
    15241 gttagaaagg atctctgtat aaatagagat ccttttttat gtttataaaa agaaaagaag
    15301 tgaatttgat gaagaagaaa aattctacta ttagtgttaa gtatgtctgt tttatagttt
    15361 ttattaaaat acgatactgt ggcatgttta ttcattggag taattaaatt ttgttaagga
    15421 tgaaattcaa taaaagcgtt attttaatag gctgttacga aatttaattt gaaaggcaca
    15481 tccaaatgat aaaaaaagag cactataaat cagtgctctt tttattagaa attgcttagt
    15541 tcttaaaaat aaaatcttta cggacaattc acaatggtaa taatgacgct agccattgtt
    15601 ccaggagaat caagaagtga agcagtaacg gttactgttc caggcccatt agcggctaga
    15661 aatacagcgg taaagttacc tgaggcattg gtaatgacag caagaggaac catgaaagca
    15721 agagatgggt tactaaatga aaaactgacc actactcctg gagtaggact accgtttact
    15781 aatacttgac ccgaaaaaaa taaagtatta tttccttgag tggatacaca tgctgtggtt
    15841 tcgttagaag tcaaggtaat agatgcaggt ccagcaggaa gattaaatcc agttggccca
    15901 gttgatccgg taggtccggt taatccagtt agtccggtta atccagttgg tccggttgat
    15961 ccggttaatc cggttgatcc ggttggccca gtcggtccag ttgatccggt taatccagta
    16021 gctcctgtag aaccggtggg accggtaggg aattgaaaag gttgaacagg tggaagtgta
    16081 ggtccaatag aacccggatt aagtgcagca aaagataaaa acttgtccat tatttatcac
    16141 ctctaaaaat cgtattacta atagtaaatg taatgataga gcaaagtgaa acggacaagc
    16201 ggttttattt taacaaatta aacaaagtag ttatatgata gaaagagaga ttagtatgat
    16261 tcctttagaa attaaatata aaaaggcgat tatcttcaaa tcgcctttta ggtaatgccg
    16321 tgtaatttta ttcagttatt tgaaatatag tttcattcgg tttggaaaat ccatacagtt
    16381 tccttgcgaa ttttaaaatt tcttcttcac tacttgttaa agccttgaca tccttgttaa
    16441 gggaatgacc atccttcttt acagaagata atttttgttg ttccgtatta agtgtgattt
    16501 gtttttcttt aatcatttct tgttggttat tcagagaata ttgaaggaca aaaattatag
    16561 gtaatataaa agccaaagta gttataatac ggcgtcttgt ttttttaata ctaccttgtt
    16621 gggtattagg attcacttgc tgtgagggta tattaggatt tgattggtgt gatgatactt
    16681 ttgggatgtt tcccattaaa atgcctccat tactgattgt cgaatttaaa ccgtttaata
    16741 gtatataaat gttcaataag gattttagaa gatattttaa tataggtgag ttttgtaaag
    16801 tttaaacaaa atctttattt aaataaaaga aaccccgctt gtctctcggg tttctgaagg
    16861 caatgaaagt actcgactaa ttaaagattc catgaatttt ttggtgaaaa tactggtgaa
    16921 ttcgtctgaa ttaatgaggg catctaaagc tttatacgta cgtgaagtaa ttaaaaatcg
    16981 atttataaga gttagcttgt tttttcttaa tagcccacct aatcagtaaa tacatatgtc
    17041 tgttgaaatc tttacgtgtt cattgataaa aagctgacta tattcagtca gctttttgta
    17101 taatacattc tagtatttat cggttccaaa agacatattc tttcctttac gttgacatta
    17161 aaaatattac caattttttc ttttacaatg gcaacaaata aagaaacatt tacaacgaca
    17221 cttatttcgt ttagaactcc aatcatcatc acgatgacac ttttctttag atttccacca
    17281 atcatcatta caatgttttt cctgagaact ccaatcgtca tcacaatgac acttttcttt
    17341 agatttccac caatcatcat tacaatgctt tttctgagaa ctccaattat catcacaatg
    17401 atgcttttct ttagatttcc accaatcatc acaacaatgc tttttctgag aactccagca
    17461 atcatttttc caggacattt atttctacct cctttcaata gtgttcatag tattctatgt
    17521 tttaataaaa aaatggcttg tttattaacc tactatttta tctttatatg atagagtgtc
    17581 ttctactcga tatagaattc atacaaacta tgctaatttt taagagaaag tggagagaac
    17641 tactactagt tatggtattt ttcaataaac acttgttgaa gaaaatgttc tgattacaaa
    17701 taatatctta ttttcgagta cgctttttaa atgtatattt cacaatgaaa aatgggaaat
    17761 ccacaaataa agtctatgta tatgtgagtt aatgggaaaa tctagtgtgt ttttaagggg
    17821 cgtcttattt aaaagaaaaa aggtttgttt tagaaagtgg tgtctaaaca ttaaatggag
    17881 taggactaaa ttcacggccg ctcattaaaa agcttttaat taggagaagt ctgtttttat
    17941 aatgaataat gaaaagaaag tttggtacaa ttgtttgttt ttttcttttt atgtgtttgc
    18001 ctcgtaccct tttaagctag tggacatact ttactaatag aaaggattag ggggtgaggt
    18061 attgggttct cgatttaata attgtaaaaa gaagtgtaca tgtaaacaag atgattgttg
    18121 ggaagtattc gaagagtgta aaaaagaaca gcatgagaaa tgtgataatt cttgtgtaca
    18181 aggaattaga gatgaactta agaaattaat taatcgaaca gttcaaatta atacagaggg
    18241 acgtacttat gtaggtactg tttcgtctgt aagttgtgat gtagttaggc ttgcggctat
    18301 tcctggatcg gttggagtaa ttatttccat ttgcaaaatt gaagcaattt tcccaccggt
    18361 tacaacggtt actgctgact ttgattttaa tggtattgat gtagcaaaca aagcataatt
    18421 atgctgcttt tttgtaaagc cattcacatg aatggcttta ttttaatttt atataaaagg
    18481 agaatatatt ctttatatag aaataagttt gaggttataa agcatgatgt acgaaaggag
    18541 caaggaagtg attaaactag aaagctttaa gaaatctgat tttaaacaat taataaattg
    18601 gattaattcc gaagaatttc taatacaatg gtcaggaaat gcattcacat ttcctttaga
    18661 cgaacagcaa ttagagaagt atatagaaag tgcaaataca ctcgctttca aagtggtaga
    18721 tgaagagact tcagacgtta ttggacatat ttcgcttggg caaatagata atattaataa
    18781 gtccgctaga attggaaaag tattagttgg taatacgaag atgagaggac gttctatagg
    18841 aaaacatatg atgaaagcag tacttcatat tgcttttgac gaattaaaac tacatagagt
    18901 aactcttggt gtgtatgatt ttaatacatc ggccatttca tgttacgaaa aaatagggtt
    18961 tgtaaaagaa ggcttattaa gagagtcaaa aagagtagga gaaacgtatt ggaatttatg
    19021 ggaaatgagt atgttagaat atgaatggaa gaagtagcaa cgatagtaat ttataattat
    19081 attatgttaa caaaggggct tggtgggtat agtggataat aaaacaaaaa taatttcaat
    19141 tgcagctgtt tcggggggag gtaaaactac aattacagaa agattaaagc ataagtttaa
    19201 aaactcaaaa gctctatatt ttgatagtta tacatttgat aactctcctg ctgatatttg
    19261 taaatggatt gatgatgggg cgaattacga cgagtgggta ttaacaccat taattcatga
    19321 tattgagcaa cttatacaaa ataatatctt agactatatt attgtagatt atccttttgc
    19381 atacttaaat agtgagatgc gaaaattcat tgatgtaact atatttattg atacgccttt
    19441 agatattgcg atggctagaa ggattttgcg agattttaag gaaggtacaa tagatgaaat
    19501 acataatgat ttggaacatt acatgacata tgcgagaaaa gcttatttag aggcaattca
    19561 tactgttaag ccgaattcag atatcatatt ggatggttct ttatctgtaa gtgaaataat
    19621 taatcacgct gtagaggaac ttggccgaag agaagtgatt gtcaatggtt aaatgtataa
    19681 tagatgctgt taggtggata attgaagtaa gagagagata aatgtgtaca ctttatttca
    19741 atataattgg caagtaagag atgattggtt taagtggtgt gaacaacttt cagaggaaga
    19801 tttactttgc aaactggggg tatgttaaaa acatgatttc atattgtaga tgtagagtat
    19861 agttggatta gtgttcttca aggataagaa gatagagaac cgcaatttaa agattatcaa
    19921 tcgattcaaa aagtgaaagc gttatctgat ttatataaat gagaacttga agtttttttg
    19981 cagtcataat catctagcct agaatgctag cacacttaaa ataagccgta taaaaagtta
    20041 atcattggtg ctttgattat ataatgtcgg cgaaataaat agtgtgaagg acagctattc
    20101 taacaagtat tttatgtaac gttcgtatat ttaaattttc ttgtaattaa tcgaattcta
    20161 attttttaga aacggataat gaggtatggg tgttgatctt ttttattgaa taaaatggat
    20221 tgatttttcg gattttcatt acaatataaa aattaaaatt ttgttagttg ttaaaaaaaa
    20281 gatgagaaaa aaatagaaaa agaaggctaa tgcccgcttt ttcttttaat tgtgtgccag
    20341 gcatggcaac tgtctaggtg gtgaaagtcc actatggggg tacacatcga ccaaccatta
    20401 aggaagcgca aggtgcttac cgtgaggtgg gggctgaagg aagcgtggaa taaaatcttg
    20461 gctcgacgaa cagaaatctg atacgaaggc tctataaagg gataagactc caattcaagt
    20521 taaagtccaa atagatgtgc gtaactttgt agagtaaatc aggcgagtaa aagaggaaag
    20581 atagttgtct taccctggga gatcttgcgg atgtactaac agtacagtcg aaaatggtta
    20641 gccgcgagaa gtcagccgaa gccatagtag tgaactaagt tcatgaaggg ctgaacagtt
    20701 tatagtgttt caacgccacg aatgcgtaag tgacctactc tgaatgtgtt aatggtagaa
    20761 agtatgagcg tatctcaaag gataaccaaa acagaggtat cacttattac gtgaggggga
    20821 aaggagaaac gagtgtggaa cttttagaaa caatattaag taatcaaaat atgaatgaag
    20881 cctacttacg cgtgtataaa aacaaaggtg caagtggagt tgatggcgta acagtcgacg
    20941 aactaaagca atatctgaag gagaacaagg acgaactacg tcagcgcatt agaacaagaa
    21001 aataccaacc acaagctgcc ttaagagtgg aaatcccaaa agagaatggc aagatgcgca
    21061 agctgggaat accaacagta gtggatagag tcgttcaaca agccattcat caaatactta
    21121 gcccgatatt tgaaaagcag ttcagtgaat tcagttatgg ctttagacca aaaagaagtt
    21181 gtgaaatggc aattgttaaa agtttggagt ttctaaatgc tggatatgag tggatagtgg
    21241 atattgattt ggaaagattc tttgatacag ttcaccacga taaattgatg cgaattatat
    21301 ctaacacaat aagcgacgga gatgtaattt ctctcataag aaagtactta gtcagtgggg
    21361 ttatggtgaa tggaaaatat gaagaaacat cagtcggaac tccgcaagga ggtaatctca
    21421 gccctctttt aagcaatatt atgctgaatg aactggataa ggaacttgaa agtagagaac
    21481 tccaatttgt gagatatgcc gacgacgctc ttatctttgt gaaaagcgag aaagcggcga
    21541 gcagagtgat gaaatcaatc gtgagattta tagaaaagaa tctaggtttg atagtcaata
    21601 cggaaaagag taaaatctct cggccagaag atttaaaatt tttaggcttt ggatattatt
    21661 acaactctaa ggatgagaga tatcaaacga aaccacaccc aatctcagta cagaaacttc
    21721 aaagaaagct tcgacaactg acaaaacgaa actggagcgt tccgctagac tatcgaatat
    21781 tgaaactaaa acaagttata tttggatggg taaattactt caggattaca aatatgaaag
    21841 gcgttatgaa gcaagtagat aagaagcttc gctccagaat tagagtgatt atttggaagc
    21901 aatggaaaat accgaagaag caaatcaaat cgcttgttca attagggatt ccggaggaag
    21961 aagcgaaggg attaacctac tgtcgaaagg gctaccgata tataggatta tcgaaagtcg
    22021 ttcaaagggc tatgtcaaat caaagactaa agaagagggg cgttccttct tctctagaac
    22081 gctatctaaa agttcgcact gcaatataaa ctgaaccgcc gtatacggaa ccgtatgtac
    22141 ggtggtgtga gaggggcgag aataaattaa tttattttcc ctctactcga ttggtaatta
    22201 atcacagatt ggtatcccaa gcactcttag agctaatgct acttgaaggg aaatctctaa
    22261 tctagcaatt tcaataccag ctactgaaag aactaaaaaa ggttgtccgt ttacaaatac
    22321 aacgcaacta tccatagtta agcctccttt ctagtaatct actatagtat atgagtagaa
    22381 ctttaaagtg taatagttca attgttggat ttaatagaat taatagatta acctatttaa
    22441 actaaacaaa cgaacacaac gaaaggaaac agagatggat gtatgcctca aaaaacatag
    22501 gttttaagac atgtaatatg atatgaaatt tatcatattg gtcagctatc tatatgggcg
    22561 agagagttaa acttgcaacc agtttcagca aatttacttg gaagaggatg atagaattaa
    22621 aaaccgactt gcatctcaag cgcaagtcgg ttatatatat aagaagattt cttaattgaa
    22681 atcctcggat tttttttgac gtatatgtaa aaacattaag gtggtaatga ttaaaaaaat
    22741 cattatagtt tgtataatta aatttttaaa ctgaagcaat attgtccaag atgtaagggc
    22801 gtctttaaaa gcttggagtg cagagtacga ggaaggatca aaaccatact ggagcaactt
    22861 ttttgtttca ataaatgaaa tgttttcttc atctgcatct aatattactg aaattagtct
    22921 agtatctcca agttttgctg tactgacgaa actataatta ccgttagttg aaaaactagt
    22981 ttgtaagcca tcaacacctt gaagtttaat gttttcatta agggaatata tcattttatt
    23041 cgtattgaaa acctgggaat ctttgaaggt aaattggtaa gaggttagtt tcgtaatatt
    23101 caatacatct ggaaaatctt ttactaatcg tgctgctagt ttagctgcgt ctattgctgt
    23161 tgtagttgat tgtttatttg tatcatgatt aattccagta gagtttagaa atggagatgg
    23221 ttgtaataac tttagttctt ttgctttttt attcattaat actgtaaagt tatcttcatt
    23281 tccagcaatg tgttctgcta gggcgagtgc agaacgatta ttccctgcca gtagcaatgc
    23341 atgaagtaaa tcacgaaccg ttgttttatc attcgatgtt acttgtatag ggcttgtttc
    23401 tactcggaaa acttcgttac ttatttgtac gaagtcatct aactgtattt ttctatcatt
    23461 tagttgttcc aatacgatat attccgtcat taatttagat aaagtagctg attgtactgg
    23521 ggtttcttca ttttttttat aaacaatttc acctgaatta gcatttatta aaatagctga
    23581 tttagcttga ataatcggac catttacata aagataaaaa tataaaacga taagtgcagt
    23641 aatgaaaaaa gataataata aaatagcgaa tttttttaag aattgcataa gtgatcctcc
    23701 tattatgaca tcaataatag tattgtaaaa aggaatgctt aattaggaag aaagaaaagg
    23761 taaagaattt ctaaagaatt ataaaggatt attaaattta gggaaataat agaaaaagtt
    23821 caatttctta tatgataaga aattgaactt tttatttgta atattaacat ttgtatggaa
    23881 gtagttttac agtgaatgtt gttttttcgt catcactata tacttcaatt gttcctttat
    23941 gcaactcgac tatacttttt gcaattgcta atccaagtcc agatccacca gtgtttgtag
    24001 agcgagattt ctcaacgcgg taaaaacgtt caaaaatatg aggtaaatcc gtactaggaa
    24061 taggttgtcc gtaatttgtt atatcaattg taatcatatt attgctttca taagcagtaa
    24121 ggtcaatata gcgaccttcg cttccataag cgatagcgtt tataataaga ttttcaaaca
    24181 cacgcactaa tttgtcacca tcagctaata ccataagctt ttgagacggg aaagaaggcc
    24241 gacattctat attagcttct tgaacctgta tgcggaattg aacagttaat tgtccaagta
    24301 actctacaat atcaatagga acagaataca agcttaattc tttattttga acacgtgtat
    24361 attcgaacaa gtcattcatt aatgcattaa gacgagttac tttatcgtaa atgacttgaa
    24421 tatagtatcg caattccact tcatctctat aattatcatg atggattaaa tttacgtatc
    24481 caactataga agtaaggggg gtgcgtaagt catgtgatac atttgtaata agttcacttt
    24541 ttgcttgttc cgcttgtctt tcttcatcaa tggagacttt taattgttca acaatttcat
    24601 tgaccccgat tgctaattct tctagataat tatgatttac aatagaaact ttatgattga
    24661 agtttccatt tgcaatataa cgaatttctt ctatcatttt ttttatacaa gtttcataat
    24721 aaagtttttt ctcgtgacga taaaaaatgt aaagatagga tgaaaaaata gaaaataaaa
    24781 acaaataaga tacaatcatc atccataaag actctttaat ccctttatac ttttcataac
    24841 caaaaattcg aatgaattct ttaccgagtt cagttagagt aagtgaactc tcaattacac
    24901 tcgtaacgag gcgataaata attagttcag taataggagt gagtgtgata gctaataaaa
    24961 gccaaaaaat aagtttccat ttaggaatat cttttaatat atcaaatgct tcatttctca
    25021 attttatagc caactcccca aacagtatga atcaattttt ctccattcat tactgtttca
    25081 agtttatctc gtaagttgct aatatggacc attaccgtct tatttgaacc ataaccatct
    25141 tcattccaaa cgcgttcgaa aatttcttct gaactaaata ctcttcctgt attactcgca
    25201 agtaaatata aaatatcgaa ttcaatagag gttagttta
//
