LOCUS       NZ_CM002285            21017 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8687444
            Orig. end                         :: 8708461
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21017
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="42"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21017
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21017
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11017](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11017)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(226..240)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.2"
                     /tool="antismash"
     assembly_gap    668..1530
                     /estimated_length=863
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <1531..2318
                     /locus_tag="M878_RS87330"
                     /old_locus_tag="M878_40725"
     CDS             <1535..2318
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126109.1"
                     /locus_tag="M878_RS87330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40725"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_023552973.1"
                     /transl_table=11
                     /translation="GCAPWGPDHPDTLRCRHNLACTLGRLGRLEDACRMAQEAADARAR
                     VLGADHPDTLVSRCEVAYAQGQSGHWQEALGIYREVAGIRARVLGADHPDTLAARYETA
                     LSLGRLGRSTDALRLYRELIVDRTRVQGPAHSDTLRARHGLGVNLGRLGRWEDALAEAR
                     DVCLLREQTLGPAHPDTLVSRREVAVALGWLGRWAEALIEYRRVTATREQILGPDHPDT
                     LAGRSDEAHCLERLGRGTEAGELYRRVAVDRRRAASDGA"
     gene            2546..4111
                     /locus_tag="M878_RS87335"
                     /old_locus_tag="M878_40730"
     CDS             2546..4111
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670835.1"
                     /locus_tag="M878_RS87335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40730"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_023552974.1"
                     /sec_met_domain="DAO (E-value: 1e-09, bitscore: 37.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPANAHTRTYDAVIVGGGHNGLVAAAYLARAGRSVLVLERLDHTG
                     GAAVSTRPFAGVDARLSRYSYLVSLLPQKIVRDLALDFRVRARTVSSYTPAERDGRPTG
                     LLVGGGEQRTREAFARLTGGEREYAAWQRFYGRTAHVAERVFPTLTEPLPSRDELRRRI
                     DDETAWRALFEEPIGVAVEENFADDLVRGVVLTDALIGTFADAHDPSLVQNRCFLYHVI
                     GGGTGAWDVPVGGMGALTDALAAAARSAGAVIATGHEAVRIATDGQTAEVTYRTADGEG
                     VAAARHVLVNASPQELAVLTGDPSPEPAEGAQLKVNMLLTRLPKLRDPAVDPREAFAGT
                     FHIAEGYRQLATAHAQAAAGELPATPPSEIYCHSLTDPTILGPDLAARGYQTLTLFGLH
                     TPARLFDRDNDTVREELLKATLAQLDAHLAEPLADCLATDADGRPCIEAKTPLDLERDL
                     RLPGGNIFHRALSWPYAQQDTGRWGVETRHPNVLLCGAGAVRGGGVSGVPGHNAAMAVL
                     ETTA"
     gene            4211..5323
                     /locus_tag="M878_RS87340"
                     /old_locus_tag="M878_40735"
     CDS             4211..5323
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016703 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of one atom of oxygen (internal
                     monooxygenases or internal mixed function oxidases)
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988006.1"
                     /locus_tag="M878_RS87340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40735"
                     /product="nitronate monooxygenase"
                     /protein_id="WP_023552975.1"
                     /transl_table=11
                     /translation="MQTELSRTLGVEHAVFGFTPFPAVAAAISRAGGFGVLGAVRYTAP
                     DDLKRDLDWIEAHAGDRPYGLDVVMPAKKVEGVSEADVEAMIPEGHRQFVRDTLAEHGV
                     PELAEGEASGWRITGWMEQVARTQLDVAFDYPIRLLANALGSPPSDVVARAHDRGVLVA
                     ALAGSARHARKHQEAGIDIVVAQGYEAGGHTGEIATMVLTPEVVEAVDPLPVLAAGGIG
                     SGQQVAAALTLGAQGVWLGSVWLTTTEADLHSPALTRKLLAAGSGDTVRSRALTGKPAR
                     QLRTEWTDAWDDAAGPGTLPMPLQGLLVAEAVSRIQKYEVEPLLGTPVGQIVGRMNSER
                     SVQAVFDDLTRGFERAVDRINRIAGRSGQS"
     gene            5320..6870
                     /locus_tag="M878_RS87345"
                     /old_locus_tag="M878_40740"
     CDS             5320..6870
                     /NRPS_PKS="Domain: AMP-binding (7-411). E-value: 8.4e-76.
                     Score: 247.1. Matches aSDomain:
                     nrpspksdomains_M878_RS87345_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988005.1"
                     /locus_tag="M878_RS87345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40740"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_023552976.1"
                     /sec_met_domain="AMP-binding (E-value: 5.5e-79, bitscore:
                     264.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPPAGFWAQAAQHPDRTVLVAPDGEEWTAGRLHGAANRLVHGL
                     RAAGLERGDAFAVVLPNGVEFVTAYLAATQAGLYLVPVNHHLVGPEIAWIVADSGAKVL
                     IAHERFTDAARAAADEAGLPATHRYAVGAVDGFRPYAGLLDGQPESPPTGRELGWVMNY
                     TSGTTGRPRGIRRPLPGKAPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYHTAVLQFAGA
                     SLHIGHRLVLMDKWTPGEMLRRIDAHRCTHTHMVPTQFHRLLALPDEVKARYDVSSMRH
                     AIHGAAPCPDHVKRAMIDWWGHCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISEL
                     AVFDDDGNRLPPGELGTVYMKMSTGGFSYHKDDAKTRKNRIGDFFTVGDLGFLDEDGYL
                     FLRDRKIDMIISGGVNIYPAEIESVLLSHPAVADAAAFGIPHDDWGEEVKAVVEPAPGH
                     DPGPALAAALLDHCASQLAGYKRPKSVDFITEMPRDPNGKLYKRRLREPYWEGRTRAV"
     aSDomain        5341..6552
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS87345_AMP-binding.1"
                     /evalue="8.40E-76"
                     /label="M878_RS87345_AMP-binding.1"
                     /locus_tag="M878_RS87345"
                     /protein_end="411"
                     /protein_start="7"
                     /score="247.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FWAQAAQHPDRTVLVAPDGEEWTAGRLHGAANRLVHGLRAAGLER
                     GDAFAVVLPNGVEFVTAYLAATQAGLYLVPVNHHLVGPEIAWIVADSGAKVLIAHERFT
                     DAARAAADEAGLPATHRYAVGAVDGFRPYAGLLDGQPESPPTGRELGWVMNYTSGTTGR
                     PRGIRRPLPGKAPEEAYLGGFLGIFGIKPFDDNVHLVCSPLYHTAVLQFAGASLHIGHR
                     LVLMDKWTPGEMLRRIDAHRCTHTHMVPTQFHRLLALPDEVKARYDVSSMRHAIHGAAP
                     CPDHVKRAMIDWWGHCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAVFDDDG
                     NRLPPGELGTVYMKMSTGGFSYHKDDAKTRKNRIGDFFTVGDLGFLDEDGYLFLRDRKI
                     DMIIS"
     CDS_motif       5803..5841
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS87345_0001"
                     /evalue="4.50E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="M878_RS87345"
                     /protein_end="174"
                     /protein_start="161"
                     /score="13.2"
                     /tool="antismash"
                     /translation="NYTSGTTGRPRGI"
     gene            complement(6904..9813)
                     /locus_tag="M878_RS87350"
                     /old_locus_tag="M878_40745"
     CDS             complement(6904..9813)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571014.1"
                     /locus_tag="M878_RS87350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40745"
                     /product="AAA family ATPase"
                     /protein_id="WP_031226979.1"
                     /transl_table=11
                     /translation="MAMEPRQPITEQRTLIERRRELQVLEAAFRELRRTADGAPRTRHR
                     GLLAFSGSAGLGKTALITEARDRAAAYGLAVLSGRGGETEQGSAFRVVRQLVQPSLARM
                     DGAELRTFLGTWYDILAAVLGLEARGPAPAPDPTGVREGLDWVMTRLTVKKAPVVLLLD
                     DLHWADAESLSWLASFASRVDDLPLLIVVAYRPEELPAETGELRTLLGGDRPHDLAHLT
                     ADGVARIVRNEIGEQAEDQFCKECWSATDGSPFEAVELAIGLAERKLSGTKDDLPTMRE
                     LAAAIKGPGLIERLERLDTATIRFAQTAAVLGSPFSPQLAATIAVLGDEAVAEATQALR
                     AARILADGHGPEGELEFLHPLIATTIYRSIRTGFRVGLHNTAAQTVLAAGYGPTAAARH
                     LLEVPCEGSPETVACLREAAREYLRAGATEAAGRLLTRALQEPPLPEDRAALLHELGCA
                     TFLIEPTATVRHLRQALEEPDVDPDLRASIVYRLTTALAHTDQLAEAVAVAAEEARQAT
                     NPRVKLRLQADQFVWSMVRTDDPDSPARSRTLARLAEQLPGRSLEERYILGLRAWDAAK
                     RGEPRQTALTYAEKALRGGMSWTDENRGFEVPLSVALVFMYGDQPRRAEELFEEGIAEC
                     AGKGWHGSHLAFGQTIAGYVRYRRGCLAEAEDLVREGLRIADKMEGVVAAQLFGVSILI
                     QTLLARGRVTEARALADEHHFGDVIPNAVIYPDPRTVYAELLLEEGRHAEAASLLSSVG
                     DWLDKRAWRNPAWCPWQLHLASALARSAPDEAVGHAQDAVKRARDFGAASTIGQALCTL
                     AEVTSGPAALGLYAEAVDHLEQSPAAYELARAQVGHGAALSHDGRLQEAADRLYQGLEG
                     AVHCGAEALAARARAELSAAGMRPLPLRYAQADTLTTQERRTAELTVQGQSVEVIAKEL
                     HLTEQGVRQLLASVYRKIGTDAAGLARSLESLPHRHYGH"
     gene            complement(10001..11017)
                     /locus_tag="M878_RS87355"
                     /old_locus_tag="M878_40750"
     CDS             complement(10001..11017)
                     /EC_number="4.2.3.162"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988562.1"
                     /locus_tag="M878_RS87355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40750"
                     /product="(-)-alpha-amorphene synthase"
                     /protein_id="WP_023552978.1"
                     /sec_met_domain="T1TS (E-value: 9.5e-57, bitscore: 192.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLTTTHEEIALGVRGAAPVPNLRDLIDTHLHMPFPFQWNPHES
                     EAAAGVEAWLSRWGLTREPGVAAMIARTRPAELASRTSPTVDSGLLQIVANQIAYQFVF
                     DDRAEDLGRRSPGRLLPMLCESIAILRDGSPPSTALGAALADLHRQVRARCTPAQAARW
                     AWKSREYVHGLLYEAVAQAQPFLLRTGECTSIRSLTAGVEPFYPLYEAAQPCELAAAEL
                     HSPVVRRLSRLSADAAVWTADLFSAAKEQRAGEMINLALAYQRAHRCSLQDAVFLAIQQ
                     INGTITEFQRLYLEIEPELSPAGVGYMAGMIGWIRGCYDWSRTVPRYADAASVPAVP"
     gene            complement(10992..12458)
                     /locus_tag="M878_RS87360"
                     /old_locus_tag="M878_40755"
     CDS             complement(10992..12458)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="M878_RS87360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40755"
                     /product="cytochrome P450"
                     /protein_id="WP_078630495.1"
                     /sec_met_domain="p450 (E-value: 1e-65, bitscore: 221.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAVPEHKRKWTTGTAPGIFPLLGHGIAFYRRPLAFLNSLPAHG
                     DLVEIRLGPQRAWMVCHPELTHEVLMDPHTFDKGGPLYDRLGKLMGDGLVTCRQPTHRD
                     KRRLLQPGFRPSHVAAYTDLVIEEATSVLDTWPVGRTVPVTEAMMTLTTRVISRVLLSD
                     ALDDATTAEVRDCLTDVVRGLFVRTVVPIDALFRLPTPPNRRYRRALSRLHAIIDKAIA
                     ERRGGAERDDVLGTLLAATRGDGDGAAITDQEVHDHLITLLLTGVEAPALCLADAFSLL
                     ARHPAAEHKLHAELDAVLPGGRRPGPDDLPHLVQTRCVISETLRHSSPGWLFTRVATRE
                     TELAGCRLPAGATVLYSPYLLHHDPSSFPDPERFDPDRWLPGRPTAAQRRALMPFSAGN
                     RKCLGDEFAMVEATLALATLAGHRRLRHLPGYVDEIPRPGITMGPRALVMACQARSAAP
                     SSAASLAPRTVADPGASDSRTAGDHLDDNA"
     gene            12739..14235
                     /locus_tag="M878_RS87365"
                     /old_locus_tag="M878_40760"
     CDS             12739..14235
                     /NRPS_PKS="Domain: AMP-binding (13-404). E-value: 1.9e-98.
                     Score: 321.7. Matches aSDomain:
                     nrpspksdomains_M878_RS87365_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007446661.1"
                     /locus_tag="M878_RS87365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40760"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_023552980.1"
                     /sec_met_domain="AMP-binding (E-value: 7.6e-100, bitscore:
                     333.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQGHGSTVDGVLRRSARRTPARLAVEYGERRWTYEELDDAVSRA
                     ASVLLAQGLTPGDRVGAYGHNSDAYLIAFLACARAGLVHVPVNQNLTGDDLAYLIDQSG
                     STLVLADPDLTVRLPDSMRALPLRDAEGSLLARLADAPPYDGPEPRTDDLVQLLYTSGT
                     TALPKGAMMTHRALVHEYLSAITALDLSAGDRPAHALPLYHSAQMHVFLLPYLAVGATN
                     IILDAPDGDRLFDLVEAGRVDSLFAPPTVWIGLAGRPDFATRDLDGLRKAYYGASIMPV
                     PVLERLRARLPRLAFYNCFGQSEIGPLATVLGPDEHEGRLDSCGRTVLFVDARVVDDKG
                     KDVPDGTPGEIVYRSPQLCEGYWDKPEETAEAFRDGWFHSGDLAVRDADGYFTIVDRVK
                     DVINSGGVLVASRQVEDALYTHESVAEAAVIGLPDERWIESVTAVVVPRGEVTEDQLIA
                     HVKETLTPFKAPKRVLFVAELPRNASGKILKRELRDRFSG"
     aSDomain        12778..13950
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS87365_AMP-binding.1"
                     /evalue="1.90E-98"
                     /label="M878_RS87365_AMP-binding.1"
                     /locus_tag="M878_RS87365"
                     /protein_end="404"
                     /protein_start="13"
                     /score="321.7"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="RRSARRTPARLAVEYGERRWTYEELDDAVSRAASVLLAQGLTPGD
                     RVGAYGHNSDAYLIAFLACARAGLVHVPVNQNLTGDDLAYLIDQSGSTLVLADPDLTVR
                     LPDSMRALPLRDAEGSLLARLADAPPYDGPEPRTDDLVQLLYTSGTTALPKGAMMTHRA
                     LVHEYLSAITALDLSAGDRPAHALPLYHSAQMHVFLLPYLAVGATNIILDAPDGDRLFD
                     LVEAGRVDSLFAPPTVWIGLAGRPDFATRDLDGLRKAYYGASIMPVPVLERLRARLPRL
                     AFYNCFGQSEIGPLATVLGPDEHEGRLDSCGRTVLFVDARVVDDKGKDVPDGTPGEIVY
                     RSPQLCEGYWDKPEETAEAFRDGWFHSGDLAVRDADGYFTIVDRVKDVINS"
     CDS_motif       13207..13260
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS87365_0001"
                     /evalue="2.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="M878_RS87365"
                     /protein_end="174"
                     /protein_start="156"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LLYTSGTTALPKGAMMTH"
     CDS_motif       13768..13857
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS87365_0002"
                     /evalue="9.90E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="M878_RS87365"
                     /protein_end="373"
                     /protein_start="343"
                     /score="27.5"
                     /tool="antismash"
                     /translation="PDGTPGEIVYRSPQLCEGYWDKPEETAEAF"
     gene            14533..15162
                     /locus_tag="M878_RS87370"
                     /old_locus_tag="M878_40765"
     CDS             14533..15162
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M878_RS87370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M878_40765"
                     /product="hypothetical protein"
                     /protein_id="WP_209445591.1"
                     /transl_table=11
                     /translation="MSAPMRLPREERDPRRSRLCQGTVFAGSSAAGTAPTLLVTRPAYG
                     MGAPAVGVLGLVGAASVHCTPLAGRAADRRGPDDVTLWRLLQVIGSAGVPARGGIGGAA
                     GLVAPAGGRVLLDVAVQGGQVADQARDFALRPDARARIDTAYMTCAFLSGSAGSWLGVR
                     GYGRLGWPGVTALVALTAVIALTRHLTRGRMTAVPAQDEVTPSRVP"
     gene            complement(15217..16521)
                     /gene="paaK"
                     /locus_tag="M878_RS87375"
                     /old_locus_tag="M878_40770"
     CDS             complement(15217..16521)
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (90-335). E-value: 5.7e-23.
                     Score: 73.0. Matches aSDomain:
                     nrpspksdomains_M878_RS87375_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670831.1"
                     /locus_tag="M878_RS87375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40770"
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_023552982.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-28, bitscore:
                     98.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADATDLLDAGERLGPGELRELQLERLRTSLRHAYDHVPFYRESF
                     DKAGVRPEDCRSLADLARFPFTTKADLRENYPYGMFAVPRERIRRLHASSGTTGRPTVV
                     GYTDNDLSMWADMVARSIRAAGGRPGDIVHVAYGYGLFTGGLGAHYGAERLGCTVVPAS
                     GGMTARQVQLIRDLEPAVIMVTPSYMLTLLDEFERQGVDPRGTSLRVGVFGAEPWTQQM
                     RREIEERFAIDAVDIYGLSEVIGPGVAQECVETKDGLTIWEDHFYPEVVDPITGEVLPE
                     GEPGELVFTSLTKEAMPVVRYRTRDLTRLLPGTARVFRRMEKITGRSDDMVILRGVNLF
                     PTQIEEIVLRTPGVAPHFQLRLTREGRLDRLTVRAEARPDAVPETRAAAARSIVAAVKD
                     GIGVSVDVEIVEPESLERSVGKIRRIVDLRQRDAG"
     CDS_motif       complement(15487..15549)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS87375_0001"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="M878_RS87375"
                     /protein_end="345"
                     /protein_start="324"
                     /score="13.3"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     aSDomain        complement(15517..16251)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS87375_AMP-binding.1"
                     /evalue="5.70E-23"
                     /label="M878_RS87375_AMP-binding.1"
                     /locus_tag="M878_RS87375"
                     /protein_end="335"
                     /protein_start="90"
                     /score="73.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LHASSGTTGRPTVVGYTDNDLSMWADMVARSIRAAGGRPGDIVHV
                     AYGYGLFTGGLGAHYGAERLGCTVVPASGGMTARQVQLIRDLEPAVIMVTPSYMLTLLD
                     EFERQGVDPRGTSLRVGVFGAEPWTQQMRREIEERFAIDAVDIYGLSEVIGPGVAQECV
                     ETKDGLTIWEDHFYPEVVDPITGEVLPEGEPGELVFTSLTKEAMPVVRYRTRDLTRLLP
                     GTARVFRRMEKITGRSDDMVILR"
     misc_feature    complement(16523..16534)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            16728..17594
                     /locus_tag="M878_RS87380"
                     /old_locus_tag="M878_40775"
     CDS             16728..17594
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-265). E-value:
                     4.8e-24. Score: 77.2. Matches aSDomain:
                     nrpspksdomains_M878_RS87380_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569439.1"
                     /locus_tag="M878_RS87380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40775"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_031226985.1"
                     /sec_met_domain="PF00561 (E-value: 1.7e-17, bitscore: 62.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.7e-16, bitscore:
                     60.5, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATFTTSDGTRLAYHQRGAGEPLVVLPGGPMRASAYLGDLGGLTA
                     HRRLALLDLRGTGDSAVPADPATYRCDRMVEDVEVWRAHMGLEHMDLLAHSAGAALAML
                     YAARHPQRVRRLLLITPNPSALGMRATPEDRLAAARLRADEPWFAGAFPAFRAWLAGEA
                     DFDDVFLPFFYGRWDEVARAHTDAELEQTNEEAGERYFADGAFTPDATRTALAALTAPV
                     LVHAGERDGGPCPDLARRTAAAFPKAEFTVQPGAGHYPWLDDPEWFRKRVLAFLDGPAD
                     AAPPSAE"
     aSDomain        16791..17522
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS87380_Abhydrolase_1.1"
                     /evalue="4.80E-24"
                     /label="M878_RS87380_Abhydrolase_1.1"
                     /locus_tag="M878_RS87380"
                     /protein_end="265"
                     /protein_start="21"
                     /score="77.2"
                     /tool="antismash"
                     /translation="PLVVLPGGPMRASAYLGDLGGLTAHRRLALLDLRGTGDSAVPADP
                     ATYRCDRMVEDVEVWRAHMGLEHMDLLAHSAGAALAMLYAARHPQRVRRLLLITPNPSA
                     LGMRATPEDRLAAARLRADEPWFAGAFPAFRAWLAGEADFDDVFLPFFYGRWDEVARAH
                     TDAELEQTNEEAGERYFADGAFTPDATRTALAALTAPVLVHAGERDGGPCPDLARRTAA
                     AFPKAEFTVQPGAGHYPWLDDP"
     gene            17733..18161
                     /locus_tag="M878_RS99095"
     CDS             17733..18161
                     /NRPS_PKS="Domain: Abhydrolase_1 (1-103). E-value: 1.9e-15.
                     Score: 49.1. Matches aSDomain:
                     nrpspksdomains_M878_RS99095_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="M878_RS99095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_342452760.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.2e-06, bitscore:
                     28.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 3.1e-11, bitscore: 42.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHCRGADGADWTAVAARLAAPSRPRPVHAPDLSGHGHSDWPGDCR
                     AEAMGDDIRALPAALGHDSADGVDHSLGGIVACLLAQRHPGVVRRLVLEDGCAPDAQRN
                     APDPVWWDHMDRITMRRWSSGVVPPASSHRTRSRSPPP"
     aSDomain        17736..18041
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS99095_Abhydrolase_1.1"
                     /evalue="1.90E-15"
                     /label="M878_RS99095_Abhydrolase_1.1"
                     /locus_tag="M878_RS99095"
                     /protein_end="103"
                     /protein_start="1"
                     /score="49.1"
                     /tool="antismash"
                     /translation="HCRGADGADWTAVAARLAAPSRPRPVHAPDLSGHGHSDWPGDCRA
                     EAMGDDIRALPAALGHDSADGVDHSLGGIVACLLAQRHPGVVRRLVLEDGCAPDAQR"
     CDS_motif       17940..17981
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS99095_0001"
                     /evalue="1.30E-03"
                     /label="NRPS-te1"
                     /locus_tag="M878_RS99095"
                     /protein_end="83"
                     /protein_start="69"
                     /score="11.3"
                     /tool="antismash"
                     /translation="HSLGGIVACLLAQR"
     gene            complement(18280..19800)
                     /locus_tag="M878_RS87385"
                     /old_locus_tag="M878_40780"
     CDS             complement(18280..19800)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010033020.1"
                     /locus_tag="M878_RS87385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_40780"
                     /product="sulfatase"
                     /protein_id="WP_342452738.1"
                     /transl_table=11
                     /translation="MAFVRLPGEGVLLATALLMLPPRARRAGAVAVGVLIGLVALLKCL
                     DIGFYTVLYRPFDLVLDWGLLGNAADYLRETSGRTGELAALAGALVLTVAVLLLTTGAT
                     VRLTALMARHRARAVRVVLVLGTVWVTCVVLGLRTGGAPVASTLDADLLGDRAKQVRVS
                     LADARLFRRQAAVDAFARTPSNQLLTGLRGKDVLFTFIESYGRSAIEDPTMGPPIDAVL
                     KQSTMTLKAAGFRARSGWLTSPVTGGGSWLAHSTFLSGLWISNQQRFRSLTSSDRTTLS
                     GSFRRTGAWRTVGVVPGVLVAWPEGRFFGLDHVYDGHHLDYHGPDFGWSQVPDQYALEA
                     FQRREFGKRGRGPLMAEIILTSSHYPWAPVPRMVDWASLGDGSVFQRVRRGGKTENEVW
                     SNPESVRAEYRTSIEYSLNSLVGFLRRYGNPNTVLVFLGDHQPVPTVTANSPRKDVPVT
                     IVAHDPRVLDRISGWGWTEGLKPAAGAPIWGMDNFRDRFLKAFGPQGR"
     misc_feature    complement(20283..20296)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.4"
                     /tool="antismash"
ORIGIN
        1 cgcccggaac tgccccgtca cctcgacgag atcatcctcg gcctgctggc caaagatccc
       61 ggggaacggc cctgcgacgc gggtgtgttg gcccggcgga tcgggcgagg acacgcaacg
      121 cccttctcca gcaaggccgt tcagatgccg gacgcgcgag gcggaaccca cctgccgtcc
      181 tggacccgcg acatgaccac cggccacaag gcgctcgccg ccggactggg cgcgctcccc
      241 ccggacgcgg gggcggcact gtcgtgccgg tggctcgcag cgcccccaag gggcgcgggg
      301 ctccatcgat atgcggctcc gcctcggggc gcgaccggct gcgacggacc cgcagacgct
      361 ccacggcccg caccggcact tcctgcggag cgcttggctc tcgccgcccg gcaccgcgag
      421 ggcgtcaggc tggccgggct cggccggtgg gccgaggcgg gcgaggcgca ccgggccgtg
      481 gccgccgagc gggccgcgct gctcggcccc gaccatcccg agaccctggc gagccgctac
      541 gagaccgcct tcgccctcgt ccgcgccggc cgcgtcgccg aggcgctggc cgcctacacg
      601 agcctcgccg aggccagagc gcgcgtgctc ggcgccgacc atcccgacac cctcgccgcc
      661 cgccaggnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ccgggtgcgc gccatggggt cccgaccacc
     1561 ccgacaccct gcgctgccgc cacaacctcg cctgcaccct cggcaggctc ggccgcctgg
     1621 aggacgcctg ccgcatggcc caggaggcgg ctgacgcccg agcccgggtg ctcggcgccg
     1681 accaccccga caccctggtc tcgcgctgcg aagtcgccta tgcccagggt cagtcgggcc
     1741 actggcagga ggcgctcggc atctaccgtg aagtcgccgg gatccgggca cgcgtgctcg
     1801 gcgccgacca tcccgacacc ctcgccgccc gctacgagac cgccctcagc ctcggccgcc
     1861 tcggccgcag cacggacgcc ctgcgcctgt accgggagct gatcgtggac cgcacccgcg
     1921 tacagggtcc cgcccattcc gacacgctcc gggcccggca cggcctcggg gtcaacctcg
     1981 gccgtctggg ccggtgggag gacgccctgg ccgaggctcg ggacgtctgc ctgctccgcg
     2041 agcagaccct cgggcccgcc cacccggaca cgctcgtcag ccgccgcgag gtcgcggtcg
     2101 ccctgggctg gctgggccgc tgggcggagg ccctcatcga gtaccggcgg gtcaccgcca
     2161 cccgcgagca gatcctcggc ccggaccacc ccgacacgct cgccggccgc agcgacgagg
     2221 cccactgcct ggagcggctc ggccggggca ccgaggccgg cgagctgtac cgcagggtcg
     2281 cggtggaccg ccggcgcgcc gcgtccgacg gcgcctgacc acgtccgggt gaaggcgcgt
     2341 ggctgtgatc ggggtggaag cgcgtggccg tgctcggggc ggacgagcct gacgacggtc
     2401 ggggcgcggg cacgtggtta cggtggggac ggaggcgcgt gaccagggtc ggcagacgcg
     2461 cctggccaag gccgggacgg cggcgcgtga ccgccgtcga ggcccgcctc tggccgccgt
     2521 ggatcatcac gtgttacgaa gaaccatgcc tgccaacgcg cacacccgca cctacgacgc
     2581 cgtcatcgtc ggcggcggac acaacggcct ggtcgccgcc gcctacctgg cccgggcggg
     2641 ccgctcggtg ctggtgctgg aacggctgga ccacaccggc ggcgccgccg tctccacccg
     2701 cccgttcgcc ggcgtcgacg cccggctgtc gcgctactcc tacctggtca gcctgctgcc
     2761 acagaagatc gtccgcgacc tcgcgctgga cttccgggtc cgcgcccgca cggtctcgtc
     2821 gtacaccccc gccgagcgtg acggccggcc caccggactc ctcgtcggcg gtggcgagca
     2881 gcgcacccgg gaggccttcg cccggctgac cggcggcgag cgcgagtacg cggcctggca
     2941 gcgcttctac ggccggacag cgcacgtcgc cgagcgggtc ttcccgaccc tcaccgagcc
     3001 cctgcccagc cgcgacgaac tgcgccgccg catcgacgac gagaccgcct ggcgggccct
     3061 gttcgaggag cccatcggcg tcgccgtgga ggagaacttc gccgatgacc tggtccgggg
     3121 cgtggtcctc accgacgccc tcatcggcac cttcgccgac gcccacgatc cttcgctcgt
     3181 ccagaaccgc tgcttcctct accacgtcat cggcggcggt accggcgcct gggacgtgcc
     3241 cgtcggcggc atgggcgccc tcaccgacgc gctggccgcc gcggcccgtt cggcgggcgc
     3301 ggtcatcgcg accgggcacg aggcggtccg gatcgccacc gacggacaga ccgccgaggt
     3361 cacctatcgc acggccgacg gcgagggcgt cgccgccgcc cggcacgtcc tcgtgaacgc
     3421 ctccccgcag gagctggccg tcctgacggg ggatccgtca cccgagcccg ccgagggcgc
     3481 ccagctcaag gtcaacatgc tgctcacccg gctgccgaag ctgcgcgacc cggccgtcga
     3541 cccgcgggaa gccttcgccg gcaccttcca catcgccgag ggctaccggc agctcgccac
     3601 cgcccacgcc caggcggccg ccggtgaact ccccgccacg ccgccctcgg agatctactg
     3661 ccactccctg accgacccca ccatcctcgg ccccgacctc gccgcgcgcg gctaccagac
     3721 gctcacgctg ttcggactgc acactccggc ccggctcttc gaccgggaca acgacaccgt
     3781 acgcgaggag ctgttgaagg ccaccctcgc ccaactcgac gcccacctcg ccgaacccct
     3841 cgccgactgc ctggccaccg acgccgacgg ccgcccctgc atcgaggcga agaccccgct
     3901 cgacctggaa cgggacctgc ggctgcccgg cggcaacatc ttccaccgcg ccctgtcctg
     3961 gccctacgcc cagcaggaca cgggccgttg gggagtggag acccggcacc cgaacgtcct
     4021 gctgtgcggc gccggcgcgg tgcgcggggg aggggtgagc ggggtgccgg ggcacaacgc
     4081 ggcgatggcg gtgctggaga cgactgcatg acgcacggtg cgcggcgagc gcgcgttccg
     4141 gagcaaagaa tctgacggga cgtcagaaaa acctcttccg ccgtcaggcc ggctgcggca
     4201 tcctgcgccc atgcagacgg agctgagcag gacactggga gtcgagcacg ccgtcttcgg
     4261 cttcacgccg ttccccgccg tcgccgcggc catcagccgg gccggcggct tcggagtcct
     4321 cggcgcggtc cgctacaccg cccccgacga cctcaaacgc gacctcgact ggatcgaggc
     4381 ccacgccggc gaccggcctt acggcctgga cgtggtgatg cccgcgaaga aggtggaggg
     4441 cgtctccgag gcggacgtcg aggcgatgat cccggaaggg caccgtcagt tcgtacggga
     4501 caccctcgcc gaacacgggg tgccggagct ggccgagggc gaggcgtccg ggtggcgtat
     4561 caccggctgg atggagcagg tcgcccgcac ccagctcgac gtcgccttcg actatccgat
     4621 ccggctcctc gccaacgccc tcggctctcc gccctccgac gtcgtcgccc gcgcacatga
     4681 tcggggggtg ctggtcgcgg ctctcgcggg cagcgcccgg cacgcccgca aacaccagga
     4741 ggcgggcatc gacatcgtgg tcgcccaggg ctacgaggcc ggcggccaca ccggcgagat
     4801 cgccaccatg gtgctcacgc cggaggtggt ggaggccgtc gatccgctgc cggtactggc
     4861 ggcgggcggc atcggcagcg gccagcaggt ggcggccgcc ctcacactcg gcgcgcaagg
     4921 tgtgtggctc ggctctgtat ggctgaccac cacagaggcc gacctgcact cacccgccct
     4981 gacccgcaaa ctcctcgccg ccgggtccgg tgacaccgtc cgctcccgtg ccctcacggg
     5041 caagcccgca cgccagctcc gtaccgagtg gaccgacgcc tgggacgacg cggccgggcc
     5101 gggcaccctg cccatgccgc tgcagggcct gctggtggcc gaggcggtct cccgcatcca
     5161 gaagtacgag gtcgaacccc tgctcggcac cccggtcggg cagatcgtcg gccggatgaa
     5221 cagcgaacgc agcgtccagg ccgtcttcga cgacctcacc cgcggcttcg aacgagccgt
     5281 ggaccgcatc aaccgcatcg ccggaaggag cggccagtcg tgagcacacc ccccgccgga
     5341 ttctgggccc aggccgccca gcaccccgac cgcacggtcc tcgtcgcccc cgacggcgag
     5401 gagtggaccg ccggacgact gcacggcgcc gccaaccggc tcgtccacgg gctgcgcgcg
     5461 gccggcctgg agcgcggcga cgccttcgcc gtcgtcctgc ccaacggcgt cgagttcgtc
     5521 accgcctacc tggccgccac ccaggccggc ctctatctgg tcccggtcaa ccaccacctc
     5581 gtcggacccg agatcgcctg gatcgtcgcc gactccggcg ccaaggtgct catcgcccac
     5641 gagcggttca ccgacgccgc ccgcgccgcc gccgacgagg cgggcctgcc cgccacccac
     5701 cggtacgcgg tcggcgcggt cgacggcttc cggccgtacg ccgggctcct cgacggacaa
     5761 ccggagtcgc cgcccaccgg ccgcgaactc ggctgggtca tgaactacac ctccggtacg
     5821 acgggacgcc cgcgcggcat ccgccgcccg ctgcccggca aggcgcccga ggaggcctac
     5881 ctgggcgggt tcctcggcat cttcggcatc aagccgttcg acgacaacgt ccacctggtc
     5941 tgctcgccgc tctaccacac ggccgtcctg cagttcgcgg gcgcgtcctt gcacatcggc
     6001 caccggctgg tgctgatgga caagtggacc cccggggaga tgctccgccg catcgacgcc
     6061 caccggtgca cccacaccca tatggtcccc acccagttcc accgcctgct ggccctcccg
     6121 gacgaggtga aggcccgcta cgacgtctcg tccatgcggc acgccatcca cggcgccgcc
     6181 ccctgccccg accacgtcaa acgcgccatg atcgactggt gggggcactg tgtggaggag
     6241 tactacgcgg ccagcgaggg cggcggcgcc ttcgccaccg ccgaggactg gctgaagaag
     6301 cccggcacgg tcggcaaggc ctggcccatc agcgaactcg cggtcttcga cgacgacggc
     6361 aaccggctcc cgcccggcga actcggcacc gtctacatga agatgagtac cggcggcttc
     6421 tcttaccaca aggacgacgc caagacccgc aagaaccgca tcggcgactt cttcaccgtc
     6481 ggcgacctcg gcttcctgga cgaggacggc tatctcttcc tccgcgaccg caagatcgac
     6541 atgatcatct ccggcggggt caacatctac ccggccgaga tcgagtccgt gctgctctcc
     6601 cacccggccg tcgccgacgc ggccgccttc ggcatcccgc acgacgactg gggcgaggag
     6661 gtcaaggccg tggtcgaacc cgcgcccggc cacgaccccg gcccggccct cgccgccgcc
     6721 ctgctcgacc actgcgcgag ccaactcgcc ggctacaagc ggcccaagag cgtcgacttc
     6781 atcaccgaga tgccccgcga ccccaacggc aagctgtaca aacggcggtt gcgggagccg
     6841 tattgggagg ggcggactcg ggcggtgtga cccggccccg cacggggtcc gcgatccgtg
     6901 gcttcagtgg ccgtagtggc ggtgcggaag actctccagg gacctcgcga gaccggctgc
     6961 gtcggtgcct atcttgcggt agacgctggc aagcaactgc cgcacgccct gctcggtgag
     7021 gtgcagttcc ttggcgatca cttccacgga ctgcccctgt acggtcagtt cggcggtacg
     7081 gcgttcctga gtggtcagcg tgtccgcctg cgcataccgc aggggcagcg gacgcattcc
     7141 ggccgctgag agttccgccc tggcccgggc ggcgagtgcc tcggctccgc agtggacggc
     7201 tccttccagt ccctggtaga gccgatcggc agcctcttgc agccgcccgt cgtgggacag
     7261 tgccgcgccg tggccgacct gggcgcgggc gagttcgtac gcggcgggcg actgctccag
     7321 gtggtcgacg gcctccgcgt acaggccgag tgccgccggc ccgctggtca cctcggcgag
     7381 agtgcacagg gcctggccga tggtggaggc ggcgccgaag tcccgggcgc gcttcacggc
     7441 gtcctgggcg tggccgactg cctcgtccgg agcggagcgg gccagcgcgg aggcgagatg
     7501 cagctgccat ggacaccatg ccgggttccg ccaggcccgt ttgtccagcc agtctcccac
     7561 cgaggacagc agcgatgccg cttcggcatg ccgtccctcc tccaggagca gttccgcgta
     7621 cacggtgcgt gggtcgggat agatgacggc gttcgggatc acgtcaccga agtggtgctc
     7681 gtcggcgagc gcgcgcgctt cggtgacgcg ccctcgggcg agcagggtct ggatgagaat
     7741 gctgacaccg aacaactggg cggccacgac cccttccatc ttgtcggcga tgcgcagacc
     7801 ttcccgtacc aggtcttcgg cttcggcaag acagccgcgg cggtagcgga cgtagccggc
     7861 gatggtctgg ccgaatgcca gatgagagcc gtgccagcct ttgcccgcgc actcggcgat
     7921 cccctcctcg aacaactcct cagcccgtcg cggctggtcg ccgtacatga acaccagggc
     7981 caccgaaagc ggtacctcga agccccggtt ctcgtcggtc cagctcatgc cgccgcgcaa
     8041 ggctttctcg gcataggtga gggcggtctg ccgtggttcg ccccgttttg cggcatccca
     8101 ggctcgcagt cccaggatgt agcgctcctc caggctgcga ccgggcaact gctcggccag
     8161 acgtgccagt gtccgggagc gggcgggtga gtcgggatcg tcggtgcgga ccatgctcca
     8221 gacgaactga tcggcctgca ggcgcagttt gacgcgcggg ttcgtggcct gcctcgcctc
     8281 ctcggcggcc acggccaccg cctcggccag ctgatcggtg tgggccagcg ccgtcgtcag
     8341 ccgatagacg atggaggcgc ggagatcggg gtcgacgtcg ggctcctcca gagcctggcg
     8401 gagatgcctc accgtggccg tgggctcgat caggaacgtg gcgcacccga gttcgtgaag
     8461 gagcgcggca cggtcctcgg gcaggggcgg ctcctgcagg gcgcgggtca gcaggcgccc
     8521 ggcggcctcg gtcgccccgg cgcgaaggta ctcgcgagcc gcctcacgca gacaggcgac
     8581 cgtctcgggg ctgccctcgc acgggacctc cagcagatgc cgggcggcgg cggtggggcc
     8641 gtatcccgcg gccagcacgg tctgcgcggc cgtgttgtgc agaccgaccc ggaagcccgt
     8701 gcggatggaa cggtagatcg tcgtggcgat cagtgggtga aggaactcca gctcgccctc
     8761 ggggccgtgg ccgtcggcca ggatccgggc cgcgcgcaac gcctgggtcg cctcggcgac
     8821 ggcctcgtcg ccgagcaccg cgatggtcgc ggcgagctga ggtgagaagg gcgaacccag
     8881 tacggcggcg gtctgtgcga agcggatggt cgccgtgtcg agccgttcca gccgctcgat
     8941 cagtcccggg cctttgatcg ccgcggcgag ctcacgcatc gtgggcaggt cgtccttggt
     9001 gccgctcagt ttccgctcgg cgagtccgat cgcgagctcc accgcttcga aggggcttcc
     9061 gtcggtggcc gaccagcatt ccttgcagaa ctggtcctca gcttgctccc cgatctcatt
     9121 cctgacgatc cgcgccacac cgtcggcggt aaggtgcgcc aggtcgtggg ggcggtcccc
     9181 gccgaggagt gtgcggagtt cgcccgtttc ggccggcagc tcctcaggcc ggtaggcgac
     9241 cacgatcagc aggggaaggt catcgacccg tgatgcgaag gaagcgagcc agctcagcga
     9301 ctcggcgtcc gcccagtgca ggtcgtccag gagcagcacg acgggtgcct tcttcaccgt
     9361 gagccgcgtc atgacccagt cgagaccctc gcggaccccg gtcgggtccg gtgcgggggc
     9421 ggggcctctc gcttcgaggc cgagaacggc ggccaagatg tcgtaccaag tacccaggaa
     9481 ggtgcggagt tccgccccgt ccatccttgc caacgagggc tgcaccagtt ggcgtaccac
     9541 gcggaacgcc gacccctgct ccgtctcccc gcccctgccc gaaagcacgg ccaatccgta
     9601 cgcggcagcc cggtcacgtg cttccgtgat cagcgccgtc ttgcccagtc cggccgaacc
     9661 gctgaaggcg agcagccccc tgtgccttgt tcgcggggcg ccgtccgcgg tgcgtcgtag
     9721 ctctcggaaa gcggcctcaa ggacctgaag ttcccgtcgg cgctcgatca acgtccgttg
     9781 ctctgtgatc ggttgccgcg gctccatcgc catgtaccgt accgccttct ctcgttcggc
     9841 caggggcagc cgagcgtacg cctcgttgag gtgaggcagg ccggattggg caccaaaggg
     9901 tgaatcatga accgcgggtg ggagaatgcc cgctccgtcg ggtacgaggt ccgaatgggc
     9961 acctcccggt ggtaccgccg gcggagcgcg ccaggagcca ctacggcacg gcgggcaccg
    10021 acgccgcatc cgcgtagcgc ggcacggtgc gggaccagtc gtagcaccct ctgatccagc
    10081 cgatcatgcc ggccatgtag ccgacgcctg cggggctcaa ctccggttcg atctccaagt
    10141 agagcctctg gaactccgtg atcgtgccgt tgatctgctg gatggccagg aagacggcgt
    10201 cctgcagaga gcatcggtgc gcgcgctggt aagccagggc caggttgatc atttcgcccg
    10261 cgcgctgttc tttcgccgcg gagaacaggt cggctgtcca caccgccgcg tcggccgaca
    10321 gccggctcag ccgccgtacg acggggctgt ggagttcggc agcggcgagt tcacatggct
    10381 gggcggcctc gtacagcggg tagaacggct cgacgccggc ggtcagcgac cgtatggagg
    10441 tgcactctcc ggtccgcaac aggaagggct gagcctgagc caccgcttcg tacaacaggc
    10501 cgtgcacgta ttcgcggctc ttccaggccc accgcgcggc ctgcgcgggt gtgcaccggg
    10561 cccggacctg ccggtggaga tcggccaggg ccgctccgag ggcggtgctg ggtggtgaac
    10621 cgtcccgcag aatcgcgatg ctctcgcaca gcatgggcag cagccggccg ggagagcgcc
    10681 ggccgaggtc ctccgcccgg tcgtcgaaga cgaattgata ggcgatctga ttggccacga
    10741 tctggaggag gccggaatcc acggtggggc tggtgcggga cgcgagttcg gcggggcgag
    10801 tgcgggcgat catcgccgcc acgcctggtt cgcgggtcag cccccacctg ctcagccagg
    10861 cctcgacgcc ggccgcggcc tcggattcat gcgggttcca ctggaacgga aagggcatgt
    10921 ggaggtgggt gtcgatcagg tccctgaggt tggggaccgg cgctgcgccc cgtaccccga
    10981 gagcgatttc ctcatgcgtt gtcgtcaagg tggtcacctg ccgtccggga atccgatgcg
    11041 ccagggtcgg ccaccgttcg gggcgcgagt gaggcggcgg aggacggggc ggctgaacgg
    11101 gcttggcagg ccatgaccag tgcacgcggt cccatcgtga tgccggggcg aggtatctcg
    11161 tcgacgtagc cgggcagatg ccgcagccgc cggtgcccgg cgagggtcgc gagcgccagg
    11221 gtggcctcca ccatggcgaa ttcgtcgccg aggcatttcc ggttgcccgc cgagaacggc
    11281 atcagcgcgc ggcgctgtgc ggccgtgggc cgcccgggca gccagcggtc ggggtcgaaa
    11341 cgctcggggt cggggaacga cgagggatcg tggtgcagca ggtaggggct gtacaggacg
    11401 gtggctcccg cgggcagccg gcacccggcg agttccgtct ccctcgtggc gacccgggtg
    11461 aacagccagc cgggcgacga gtggcgcagc gtctcggaga tgacgcaccg ggtctggacg
    11521 aggtgcggca gatcgtcggg tccgggccgt cggcctccgg ggagtacggc gtccagctcg
    11581 gcgtgcagtt tgtgctccgc cgccggatgg cgggcgagca ggctgaaggc gtcggcgagg
    11641 cacagtgccg gggcctcgac gccggtgagc agcagcgtga tcagatggtc gtggacctcc
    11701 tggtcggtga tcgccgcccc gtcgccgtcg ccgcgcgtgg ccgccagcag cgtacccagc
    11761 acatcgtcgc gctcggcgcc cccgcggcgc tctgcgatcg ccttgtcgat gatggcgtgc
    11821 aggcgggaga gggcgcgccg gtagcggcgg ttggggggtg tgggcaggcg gaacagggcg
    11881 tcgatcggta cgaccgtgcg gacgaagaga ccacggacga cgtcggtgag acagtcccgc
    11941 acctcggcgg tcgtcgcgtc gtccagcgcg tcggagagga ggactcggct gatcacgcgg
    12001 gtcgtcaagg tcatcatcgc ctcggtgacg ggaaccgtcc ggccgaccgg ccatgtgtcc
    12061 agcaccgacg tggcctcttc gatgacgagg tccgtgtatg cggcgacgtg ggaggggcgg
    12121 aagccaggtt gcagcagcct gcgcttgtcc cggtgcgtcg gctggcggca ggtgacgaga
    12181 ccgtcgccca tcagcttccc gagcctgtcg tacagcgggc cccccttgtc gaaggtgtgc
    12241 ggatccatga gcacctcgtg ggtcagctcc gggtggcaca ccatccaggc gcgctggggg
    12301 cccaaccgta tttcgaccag atccccgtgc gcgggcaaag aattcagaaa cgccagcggc
    12361 cggcggtaga aggcgatacc gtgaccgagg agtgggaata tgccgggagc agtacctgtc
    12421 gtccactttc gtttgtgttc aggcacagca cggctcatgg atacctcctg cccaacgtgg
    12481 cacacgaaat gcgtgaactg ctacggactt gatgcccgca ccatttcctg cccaggttca
    12541 acggtgctcg gtatccggaa acctttctcc aaaggggcgc acagaagcac gcagaggcaa
    12601 aagtcgcctt cggcgaacga ccgttgatgc tctatgcatc gaaaacgtgg gcgacggcag
    12661 gatgttcttc cggacggtgc gggcaagcgc ctctcgggtg cttgacctgc cttcgtgccg
    12721 gaccgaggat catgagtcat gacgcaggga cacggcagta cggtcgacgg ggtgctgcgg
    12781 cgcagcgccc gacgcacccc ggcccgcctc gcggtggagt acggcgagcg ccgctggaca
    12841 tacgaggaac tcgacgacgc cgtctcccgc gcggcctcgg tactgctcgc ccagggcctg
    12901 acccccggtg accgggtcgg cgcctacggc cacaactccg acgcctacct catcgccttc
    12961 ctcgcctgcg cacgggcggg cctggtccat gtgccggtca atcagaacct gaccggcgac
    13021 gacctggcgt acctcatcga ccagtccggc agcacccttg tcctcgccga cccggacctc
    13081 accgtccgac tcccggacag catgagggcg ttgccgctcc gggacgccga aggctcgctc
    13141 ctcgcccggc tggcagacgc gccgccgtac gacgggcccg aaccccgcac cgacgacctg
    13201 gtgcagctgc tgtacacctc cggtacgacc gccctgccca agggcgcgat gatgacccac
    13261 cgggctctcg tgcacgagta cctgagcgcc atcaccgccc tcgacctcag cgcgggcgac
    13321 cggccggcgc acgcgctgcc gctgtaccac tcggcccaga tgcatgtgtt cctgctgccg
    13381 tacctcgccg tcggcgcgac caacatcatc ctggacgcgc ccgacgggga ccggctgttc
    13441 gacctcgtcg aagcgggccg tgtggacagc ctgttcgcgc cgcccacggt gtggatcggc
    13501 ctggcgggcc ggcccgactt cgccacccgt gacctggacg gcctgcgcaa ggcctactac
    13561 ggcgcgtcga tcatgcccgt cccggtcctg gagcggctgc gcgcacgcct gccgcggctc
    13621 gccttctaca actgcttcgg acagagcgag atcggcccgc tggccacggt gctcggccct
    13681 gacgaacacg agggccggct ggactcctgc ggccggaccg tgctgttcgt ggacgcacgg
    13741 gtcgtggacg acaagggcaa ggacgtgccc gacggcacgc ccggcgaaat cgtctaccgt
    13801 tcccctcagt tgtgcgaagg ctactgggac aagccggagg agaccgccga ggcgttccgg
    13861 gacggctggt tccactccgg cgacctcgcg gtgcgcgacg ccgacggcta cttcacgatc
    13921 gtggacaggg tgaaggacgt catcaactcc ggtggcgtcc tggtggcttc gcgccaggtc
    13981 gaggacgccc tgtacaccca cgagtccgtc gccgaggccg ccgtgatcgg cctgcccgac
    14041 gagcggtgga tcgagtcggt caccgcggtc gtcgtcccgc gcggcgaggt gacggaagat
    14101 cagctcatcg cccatgtgaa ggagacgctc acgcccttca aggcgcccaa gcgggtgttg
    14161 ttcgtggccg agttgccgcg caacgccagc ggaaagatcc tgaagcgcga actgcgggac
    14221 cgcttcagcg gctaggtgtg ctgttcggcg catcgggtcg cgggaaatcg gcgggcctca
    14281 tcagcgctgg tgggcggggg cgatggggga gcgtgcagct gcaaggcgga ggagggagtc
    14341 gacgatgggg gagtcgggga gcgacgacaa cgtcgctggg ggtgccccca cgcccttagg
    14401 gcagtgaggg agggggtgcc ggcccccgcg tctgcggcag gatccgccgg acaggcccca
    14461 gccctcgcgc tgacgctcgc ccgggtggtg ccggacacca caccctcgtc cgaacagcgg
    14521 tgcctcgacc ccatgtccgc cccgatgcgc ctgccgcgcg aggaacgcga cccgcgccgg
    14581 tcacgcctct gccaaggcac cgtcttcgcg ggctccagcg ccgccgggac cgcgccgacg
    14641 ctgctcgtga cccggccggc gtacggcatg ggcgcgccgg ccgtgggtgt gctcggactc
    14701 gtcggcgccg cgagcgtgca ctgcaccccg ctcgccgggc gagcggcgga ccgccgggga
    14761 ccggacgacg tgaccctgtg gcgcctgctg caggtgatcg gctcggccgg ggtgccggcc
    14821 cgcggcggca tcggcggcgc ggccggactc gtcgcgccgg ccggcggcag ggtgctcctc
    14881 gacgtcgctg tgcagggcgg ccaagtcgcc gaccaggcac gcgacttcgc actccgcccg
    14941 gacgcccggg cccggatcga caccgcctac atgacctgcg ccttcctcag cggcagcgcc
    15001 gggtcctggc tcggggtacg ggggtacggc aggctcggct ggccgggcgt gacggcgctg
    15061 gtggctctga ccgccgtgat cgcgcttacc cggcatctga ccagggggcg tatgacggct
    15121 gtcccggcgc aggacgaggt gacgccgagc cgggtgccgt gacctgtgtc cgccgggtca
    15181 ggtggttgac ccggcggagc tggggcgctg gtggccctac ccggcgtccc gctgccgcag
    15241 gtcgacgatc cggcggatct tgccgaccga ccgctccagc gactccggct ccacgatctc
    15301 cacgtccacg gacaccccga tgccgtcctt cacggccgcg acgatcgacc gggccgccgc
    15361 ggcccgcgtc tccgggaccg cgtccgggcg ggcctcggcc cggacggtca gccggtccag
    15421 ccggccctcc cgggtcagcc ggagctggaa gtgcggcgcc acaccgggcg tgcggagcac
    15481 gatctcctcg atctgggtcg ggaacagatt gaccccgcgc aggatcacca tgtcgtcact
    15541 gcgcccggtg atcttctcca tccgccggaa cacccgagcc gtaccgggca gcagccgggt
    15601 caggtcccgg gtgcggtacc ggacaaccgg catggcctcc ttcgtcagcg aggtgaagac
    15661 cagctcgccc ggctcgccct ccggtagcac ctcacccgtg atcggatcga ccacctccgg
    15721 atagaagtgg tcctcccaga tcgtcagccc gtccttggtc tccacgcact cctgggccac
    15781 acccgggccg atcacctcgc tcagcccgta tatgtcgacg gcgtcgatcg cgaaccgctc
    15841 ctcgatctcg cgccgcatct gctgggtcca gggctcggcc ccgaagacgc ccacgcgtag
    15901 cgaggtgccg cgcgggtcta cgccctgccg ctcgaactcg tccagcagtg tgagcatgta
    15961 ggacggggtc accatgatga cggctggttc caggtcgcgg atcagctgca cctgccgggc
    16021 cgtcataccg ccggaggccg gcacgaccgt acagcccagg cgctcggcac catagtgggc
    16081 gcccagacca ccggtgaaca gcccatagcc gtaggctaca tgcacgatat cgccgggccg
    16141 tccgccggcc gcccggatcg accgcgccac catgtcggcc cacatggaaa ggtcgttgtc
    16201 cgtatagccg accaccgtgg ggcgcccggt ggtgccgctg gaggcgtgca gccggcggat
    16261 ccgctcgcgc ggcacggcga acatgccgta cgggtagttc tccctgaggt cggccttggt
    16321 cgtgaagggg aaacgggcca gatcggcgag ggaacggcag tcctcggggc ggacaccggc
    16381 cttgtcgaag gactcccggt agaacggcac gtggtcatag gcgtgccgca gcgaggtgcg
    16441 cagccgctcc agctgaagtt cccgcagctc cccgggcccg agccgctcgc ccgcgtcgag
    16501 caggtccgtc gcatccgcca tcgcgttcgt ctccctcgcc gtcctcacat tccggacgac
    16561 cgatcattcg gtcgccccgt tcggggccag taattcaggc catacggctc caggcaaggg
    16621 ggcagcgcgg attttctgca ccggtccatc gccctgtgcg gcgcggcgct cccgccacgg
    16681 ccgtagagcg ttgcgccgct gtgccgtggg ccgacatgat cacgaccatg gccaccttca
    16741 ccacgtccga cggcacccgg ctcgcctatc accagcgggg tgccggtgag cccctcgtcg
    16801 tcctgcccgg cggcccgatg cgtgcctccg cttatctcgg cgacctcggc gggctgaccg
    16861 cgcaccgtcg tctggccctg ctggacctac ggggcaccgg cgactccgcg gtgccggcgg
    16921 acccggcgac gtaccgctgc gaccggatgg tcgaggacgt ggaggtgtgg cgcgcacata
    16981 tgggtctgga gcacatggat ctgctcgccc actcggcagg cgccgccctg gccatgctct
    17041 acgcggcccg ccacccgcag cgggtccgac ggctgttgct gatcacgccc aacccgtccg
    17101 ccctgggcat gcgggcgacc cccgaggacc ggctggccgc ggcccggctg cgcgcggacg
    17161 agccgtggtt cgccggggcg ttccccgcct tccgggcctg gctggcgggc gaggcggact
    17221 tcgacgacgt cttcctgccg ttcttctacg gccgctggga cgaggtcgcc cgggcgcaca
    17281 cggacgccga actggagcag accaacgagg aggcggggga gcgctacttc gccgacggtg
    17341 ccttcacacc ggatgccacc cggaccgccc tcgccgcgct gaccgcgccg gtcctcgtgc
    17401 acgccgggga gcgcgacggc ggtccgtgcc ccgacctcgc ccgccgtacc gccgcggcct
    17461 tcccgaaggc cgagttcacc gtccagcccg gcgccggtca ctacccctgg ctggacgacc
    17521 cggagtggtt ccgcaagcgc gtcctcgcct tcctcgacgg gccggcggac gccgctccgc
    17581 cctcggcaga gtagacggcc agggacacca cggctccgca cacgtcaacg cgaacggcat
    17641 caggctggcc tgccggacct ggagcccggt ggactccccc aagtactcgg cttctctcga
    17701 acccggcggg acccccatcg cccggcctgc tgctgcactg ccgcggcgcc gacggcgcgg
    17761 actggacagc tgtcgccgcg cggctcgcgg caccctcgcg tccccgcccg gtgcacgccc
    17821 ccgacctgag cggccacggg cacagcgact ggccggggga ctgccgggcc gaggcgatgg
    17881 gcgacgacat ccgtgccctg ccggccgccc tcggccacga cagcgccgat ggcgtggacc
    17941 attcgctggg cggcatcgtc gcctgcctgc tggcgcagcg gcatcctggg gtcgtacgac
    18001 gtctggttct ggaggacggg tgcgcgcccg acgcacagcg caacgctccc gatcctgtgt
    18061 ggtgggacca catggaccgg atcaccatgc gacggtggtc atcgggggtg gtcccaccag
    18121 cctcatccca caggaccagg tcgcgcagcc cgccgccctg atcccggacg ccgtgctcgt
    18181 ggcccttgac gcgggcacct ggcgcacgag tcccactcgg cggacttcct cgacctggtg
    18241 cggaagttcc ccgaccgatg accgacgtca ccggcggatt cagcgcccct gcggcccgaa
    18301 cgccttcagg aaccggtcgc ggaagttgtc catcccccag atgggagcgc cggcggcggg
    18361 cttcaggcct tctgtccagc cccagccgga gatccggtcc agcaccctgg ggtcgtgggc
    18421 gacgatcgtg accggcacgt ccttgcgggg gctgttcgcg gtgacggtcg gtacgggctg
    18481 gtggtcgccc aggaagacca gaaccgtgtt cgggttgccg taccgccgca ggaacccgac
    18541 gaggctgttc agcgagtact cgatggaggt gcggtactcg gcgcgcacgc tctccgggtt
    18601 gctccagacc tcgttttcgg tcttgccgcc ccgtctgacc cgctggaaga ccgagccgtc
    18661 gcccagcgac gcccagtcga ccatgcgggg cacgggcgcc cacggatagt ggctggaggt
    18721 gaggatgatc tccgccatca gtggaccccg gccgcgcttg ccgaactccc gtcgctggaa
    18781 ggcctccagg gcgtactggt ccggcacctg cgaccagccg aagtccgggc cgtggtagtc
    18841 caggtgatgg ccgtcgtaga catggtccag gccgaagaac cggccctcgg gccaagccac
    18901 cagcactccg ggcacgaccc cgaccgtgcg ccaggcgccg gtcctgcgga aggagccgct
    18961 gagggtcgtc cggtcgctgg aggtgaggct gcggaatcgc tgctggttgc tgatccacag
    19021 gccggacagg aacgtcgagt gggccagcca gctgccgcca ccggtcaccg gcgaggtcag
    19081 ccagccgctg cgggcccgga atccggcggc cttgagcgtc atggtgctct gcttgaggac
    19141 cgcgtcgatc ggcgggccca tcgtcgggtc ctcgatcgcc gaacggccgt agctctcgat
    19201 gaacgtgaac agcacgtcct tgccgcgcag gccggtcagc agctggttcg acggcgtgcg
    19261 ggcgaacgcg tcgacggcgg cctggcgccg gaagagacgc gcgtccgcga gggagacgcg
    19321 gacctgcttg gcccggtcgc ccagcaggtc cgcgtccagc gtcgaggcga ccggtgcgcc
    19381 gccggtgcgc agtccgagca cgacacaggt gacccagacg gtgcccagca ccaggacgac
    19441 gcggacggcc cgggcgcgat gacgggccat cagggcggtc agccggaccg tcgcgcccgt
    19501 cgtcaggagg aggacagcga ccgtgaggac cagcgcaccg gcgagcgcgg ccagttcgcc
    19561 ggtgcggccg gaggtctccc gcagatagtc cgccgcgttg cccagcaggc cccagtccag
    19621 caccaggtcg aaggggcggt acagcaccgt gtagaagccg atgtccaggc atttgagaag
    19681 ggcgaccagc ccgatcagca cgccgacggc caccgccccg gcccgccgcg cccgcggcgg
    19741 cagcatgagc agcgcggtgg cgagcagcac accctcaccc ggcagccgca cgaatgccac
    19801 gggcgcgagc tgatcgggtt gatcaggcag caacagcgcg gccagaagaa ggccgacagc
    19861 gagaacgctg acccccacgg ccacactccg cgcgatacgg gtgcccccgc cgccccgtcc
    19921 gctcaacgcc ccgatcaacg caccgaagcc gaacccgctc cagacacacg caccgagccg
    19981 cccggccttt gccgccggcc cagcagggtc ttgggctccc gcctgcccgg cagaacctcc
    20041 ggcctccccc ggcccggcag gctctccgcc ctccgccggg cccccagacg ccccggctcc
    20101 agaccgcccg gctccagacc gcccggctcc ccccagcccg gtgttcgact cgtctgcgtt
    20161 ccccggcagg tggtctggcg tgcggtggga cacccgggat ccttccgtgc gtggccggtg
    20221 gcggtggcgg tgtcggtgcc ggggcggagg gccgggaccg gcgtcgctcg accgaccggc
    20281 ggtcactgag cgtggtcgga tggcgccgat cgtgcgcaca gagtagtcct gccgggcggt
    20341 gcgggcggtg ggacaccccg gggcgctacc gccgctcggc ggccaccgcc acctgccgtg
    20401 cccaccggta gtccgccttg ccgctcggag accgctggat ggagtccgtg atcaccagct
    20461 ggcgggggat cttgtaaccc gccagccggg tacggcagtg gccctggatg tcggcgagcg
    20521 aggggtgcgc cgctccctcg cgcagctgca ccacggccgc cacatggttg ccccaggtgg
    20581 cgtccggcac cccggcgacc agcgcgtcgt acacgtccgg atgcgccttg agcgcctgct
    20641 cgacctcctc cgggtagacc ttctcgcctc cggtgttgat gcactgcgag ccccggccga
    20701 gcacggtgac cacgccgtcc tcgtcgaccg tcgccatgtc gccgagcagg acccagcgct
    20761 gtccgtcctt ttcgaagaac gtctcggcgg ttttccgtgg gtcgttgtag tagccgagcg
    20821 ggacatgacc gcactgggcg acccggccga tctcgcccgt ggcgaccggc tcgtgtgtcg
    20881 ccggatccac cacgcgggta cgggagttga ccctgaggcg gaagccgcgc tcggggcccg
    20941 agtcctccgt cgccgtaccg ttgaagccgg actcggagga gccgaagttg ttgagcagca
    21001 tggcgttcgg gaccagc
//
