LOCUS       NZ_CM002285            20970 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6780948
            Orig. end                         :: 6801918
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20970
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="35"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20970
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20970
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[<10000:10970](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      <10001..10970
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     CDS             complement(161..>686)
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126976.1"
                     /locus_tag="M878_RS79020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31745"
                     /product="hypothetical protein"
                     /protein_id="WP_063750631.1"
                     /transl_table=11
                     /translation="APAGVREVCRALCEEMSARRGGRPVELRFERFPDEIEVTGLWVEF
                     ADFDLVIVEERAEAVQQLVILGHELWHLHAGHRHHHLAGDAAARALADAPGWRGMPLTV
                     AARNGSREADEAEADDFGHRLATLFRPHLTDSATGAPQGQAQRSLSPVQRTLGYRGRDE
                     ANGAPRKREADR"
     gene            complement(161..>690)
                     /locus_tag="M878_RS79020"
                     /old_locus_tag="M878_31745"
     assembly_gap    691..1528
                     /estimated_length=838
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <1717..2175
                     /locus_tag="M878_RS79025"
                     /old_locus_tag="M878_31750"
                     /pseudo=""
     CDS             <1717..2175
                     /GO_function="GO:0046556 - alpha-L-arabinofuranosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046373 - L-arabinose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042338.1"
                     /locus_tag="M878_RS79025"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31750"
                     /product="alpha-L-arabinofuranosidase C-terminal
                     domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LAQLVNVIAPIMTEPGGPAWRQTTFFPFAQASRCGRGEVLDVRVD
                     SPTYETRKYGETDLLHASAVRAADGTVTVFAVNRSRTDALPLEVTLTGMELTTVAEHSA
                     LADADPDARNTLDDPGRVAPHPVEGTTVADGTLTAVLEPLSWNVIRLA"
     misc_feature    complement(1718..1733)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.76"
                     /tool="antismash"
     gene            complement(2162..5116)
                     /locus_tag="M878_RS79030"
                     /old_locus_tag="M878_31755"
     CDS             complement(2162..5116)
                     /EC_number="3.2.1.23"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672508.1"
                     /locus_tag="M878_RS79030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31755"
                     /product="beta-galactosidase"
                     /protein_id="WP_023551048.1"
                     /transl_table=11
                     /translation="MALSRRNFSALAGSTALGLALGGSDGTGAPSAYAAHSVPTGPAPA
                     PPSADGERHTIGYDRYSLLVDGRRLVVWSGEMHPFRLPSPSLWRDVLQKMRAHGYNAVS
                     IYVAWNYHSPAPGRYDFTGVRDLDLFLRMAAETGLYVILRPGPYINAEVDGGGFPGWLT
                     AAKGTARTDDPAYLGHVDAWLTQVNRIARKHLFTQGNGTILLYQIENEYDAHTDETGRA
                     YMSHLYKKVRADGIDVPLFHNDKGRNGYWVPGSFDTGGEKGGWLYGFDGYPSPSQTPPD
                     WGTFGPGGAKGGAGASPSTPGFVPEFGGGWFDPWGGAWFDGKGYAESRRTRDAAYERRF
                     YLTNLANGLTLHNVYMTFGGTSWGWLPAPVVYTSYDYGAAIDEARNVTGKIAPMHQLGH
                     LLQRVPDFAKLDRAADVHAEGLKVYHLTNPDTGAHVYVARNDGSHAVTTDLPTDAGRVR
                     ITVPGKDARLLTTGLRLGRRTLKYATAEPVLCVTAGRQDIALFSGRRGEMTELVLKCRA
                     EPDVMRLDPEAAWAFDGADELHVNTPLGQGGLTRVLVQKGETETPLLLLFADDATAVRV
                     FPYDTPSGTLLVYGPALLRHVELRGSEVHLTGDVTNTTSMEVWGPRGIDTLVWNGRRLP
                     TRVTLSGSLMTTGMLPAVPEVRLPGLGGWRMRTENPEVGPSFDDSGWKAADKKSSFSTT
                     PVPDGGPVLFADDYGFHYGDVWYRGTFTDSTGLEEISLAYSTGTQGLLMAWLDGEPLGT
                     HRMPVPDKNTTTRQGTWTATAAFPVREALRSPGRHVLSVLVRRMQHDQDGKGLDTHKAA
                     RGLTAASFKGASPSVSWRIQGEKAPDPVRGPMNNGGLYGEREGWHLPGFRDHDWEKTAF
                     PRAARYQGVTWYRTTFRLSVPADIDASIGLTLEDDPYRAYRAQIFLNGWNMGQYINNVG
                     PQHTFVLPNGVLRTRGTNTLALAVLSEFTTLSGPGKVSLTLLGRATGGLPVTPV"
     gene            5194..>5521
                     /locus_tag="M878_RS79035"
                     /old_locus_tag="M878_31760"
                     /pseudo=""
     CDS             5194..>5521
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126969.1"
                     /locus_tag="M878_RS79035"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="M878_31760"
                     /product="Rrf2 family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRISARADYAVRAVLELAVRQGNDPREGGGNRRRAGHPAQVPGRD
                     PGRSEAGRDRRQPAGRRRRLPAGAGRGRRHGRGCDPGGGRPDRAGPRRTPHGPRLHRQR
                     SAPAP"
     misc_feature    5530..5545
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 19.33"
                     /tool="antismash"
     gene            5660..6313
                     /locus_tag="M878_RS79040"
                     /old_locus_tag="M878_31765"
     CDS             5660..6313
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016435458.1"
                     /locus_tag="M878_RS79040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31765"
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_031226214.1"
                     /transl_table=11
                     /translation="MAGGLLLSGAVAALLSTAIPAQRPAGGPIDNPPPDKIVIDVATVN
                     GSGCPEGTAAVAVSPDNTAFTVTYSSYLAQAGGNSDPTAFRKNCQLNLVVHVPQGFTYA
                     IASADYRGFLSLQPGASATQKASYYFQGSPNTVPKSHPFNAPFNDNWEATDSTDWAQLV
                     WAPCGVLRNFNINTELRVNAGTTNPDKVSFMTMDSTDGDISTVYHLAWKQCPSA"
     misc_feature    complement(6535..6548)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.82"
                     /tool="antismash"
     gene            6596..8029
                     /locus_tag="M878_RS79045"
                     /old_locus_tag="M878_31770"
     CDS             6596..8029
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058032.1"
                     /locus_tag="M878_RS79045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31770"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_023551051.1"
                     /transl_table=11
                     /translation="MPLDTVTAPAAGPESEQRQQEQQSLSTAAARNLATTTKSEPQMQG
                     ITSRWATRMLPWVNVPGATYRVNRRLSYTVGDGRVTFVKTGSKVQVVPAELGELPLLRG
                     FSDADVLGALADKFVQKEYAPGDLIVQAGRKADQVFLIAHGKVEKIGEGPYGEEAVIGL
                     LADGDTFGGRVMSGQAKKWEFTARAATATTVLALPMTAYKAVADRHEALRAHVRHISSN
                     GHRKLNRSGEAAIELSSGHVGEETLPQTFADYEAEPREYELSVAQTVLRVHSRVADLFN
                     EPMNQTQQQLRLTIEALRERQEYELINNEEFGLLNNADFDQRISTFSGPPAPDDMDELL
                     SMRRKTRCFLAHPKAIAAFGRQCNKRGIYFGGIELNGNHLPAWRGVPLLPCSKIPISEH
                     GTTSIIAMRTGEDDQGVIGLYQTGIPDEVEPGLNVRFMGINEQAVISYLVSTYYSAAVL
                     VPDALGILENVEIARTNGS"
     misc_feature    8635..8647
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     assembly_gap    8792..9996
                     /estimated_length=1205
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            <9997..10970
                     /locus_tag="M878_RS79050"
                     /old_locus_tag="M878_31775"
     CDS             <10001..10970
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=3
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009333277.1"
                     /locus_tag="M878_RS79050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31775"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_023551052.1"
                     /sec_met_domain="T1TS (E-value: 2.7e-42, bitscore: 144.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PPAVRDDPALGESVTERLVEWTEEIGIYPGRSGEIRKADFGRLVM
                     LAHPESDDPDRLLAAAKCALSEWAVGGHYAEDLGQRLADARSVIDQSHLPLGYAPSSKR
                     SVTADPVMRALRDSLRNLRTYATTSQVRRLRHELGIMLDACDQEGRWQSSGHVPPVGEF
                     LMHRHENSFVPRMVLIDAIAGYEVPYGEFSDPRVRRALTKAGTAGVLVNDLYSMAKEDP
                     ADFSLPRLIAAEDGCSPAEAVDRTVGIHNELMLTFEAEAAALARTGSPELRRFLAGTWA
                     WLGGSREWHAGSGRSHEAPSPESASHEPAPEPAPEPAPEPAA"
     gene            11027..11902
                     /locus_tag="M878_RS79055"
                     /old_locus_tag="M878_31780"
     CDS             11027..11902
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640631.1"
                     /locus_tag="M878_RS79055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31780"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_023551053.1"
                     /transl_table=11
                     /translation="MSKISTQMESIAMRDVLRTEYQKSVAEYWNKEKDPVNIKLGEVDG
                     LYHHHYGLGEWDPSVLAGPPETRDQRIIEELHRLESAQAEVLLDHLGDITPDDRLLDAG
                     SGRGGTSFMANARFGCHMDGVSISEQQIDFANEQARQRGVTDKVRFHFRNMLDTRLETG
                     SRRAIWTNETTMYVDLFELFAEFSRLLEYGGRYVCITGCSNDVTGMRSKAVSRIDEHYT
                     CNIHPRSEYFRALAANDLVPIQVVDLTPDTIPYWELRAKSSVATGIEDPFLTAYKEGSF
                     HYLLIAADRI"
     gene            12024..13394
                     /locus_tag="M878_RS79060"
                     /old_locus_tag="M878_31785"
     CDS             12024..13394
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="M878_RS79060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31785"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_051430127.1"
                     /transl_table=11
                     /translation="MRTDRPWAKAVVIGGSYAGLVTARVLADFFREVILVERDAVDEDT
                     GVHPGAPQGYHAHAMLAKGGQILERLFPGLRDELRAAGAPVFDYGEGIDFLLPVGLAPR
                     RRTGVRIQTFTRDELERRLRRKVLALPQVTLVPSTQCTGLTRDPSGRVTGVTCRSQHTD
                     ASDPAAAEPFELAADLVIDASGRTSSLTDWLGAMGITVRPKRTVKAKVTYTSMNFDRPH
                     TSQPGHPDYYVAYQMLFAPSVPRAGVLLAVERNRWTCSLFGFQDQPPIDDEGYLKFAES
                     LQNPRLAEQIGRRTAQEPTRRYTNADNQWRLYHTVKDWPDRLLAVGDAVCVFNPVYGQG
                     LTVAAMEAELLQGMLKRHSASGRLDGLAGGFQKKVGRLVLGPWTLSTNSDLMWNPEGQP
                     LAARFAHWYNTRLFHVAVKDAAVWARFVRVVNMVASPAVLFHPLVALKVLTVTPRRT"
     gene            complement(13375..13677)
                     /locus_tag="M878_RS79065"
                     /old_locus_tag="M878_31790"
     CDS             complement(13375..13677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142131.1"
                     /locus_tag="M878_RS79065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31790"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_023551055.1"
                     /transl_table=11
                     /translation="MSTSELAWFKSSYSSSGSGDCVEVALNWLKSSYSSSGDGDCIEVA
                     LNWRKSTYSSGSGDDCVEVAVCPATIHVRDSKAKEGPQLALSPTAWSAFVTYAGE"
     gene            complement(13674..14501)
                     /locus_tag="M878_RS79070"
                     /old_locus_tag="M878_31795"
     CDS             complement(13674..14501)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660649.1"
                     /locus_tag="M878_RS79070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31795"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_245238249.1"
                     /transl_table=11
                     /translation="MGTGNGGEPESSGSLRTFGAVLQALREYHGLSREELGDLVGFSKH
                     TVASIELGRRMPDPDFVEAAEKALGNTGALRRAAEHLEREAGLASWFRRWAGLEKQAIS
                     LYTYECRMIPGLLQTEAYARQLFMDELPILTDEQIEANWVARANRQRLLRERQNSAFSF
                     IIEEQVLLRGTGGVDITRESVDQLLEIAQLRNVELQIMPLARESHAGLHGPMQLLEDPS
                     NKWFAYLEAPECGMLLSDAKVVSRLYGRYARMRSQALPLQDSVSLLQRIRGDL"
     gene            14619..15083
                     /locus_tag="M878_RS79075"
                     /old_locus_tag="M878_31800"
     CDS             14619..15083
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326261.1"
                     /locus_tag="M878_RS79075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31800"
                     /product="ATP-binding protein"
                     /protein_id="WP_023551057.1"
                     /transl_table=11
                     /translation="MTAPPLPTHTVTQRLSSTPRGARLARHLTLAQLDTWGIPHGTDTA
                     EAVAAIVAELAANAVTHGRVPGRDFELRLVRLVGSIRVEVSDTYDERRPPGPEDVTEPA
                     PLAEAGRGLVLVDALADRWEVVDRDPPGKTVRAEVDMPPWLSRRLRVRRG"
     gene            complement(15052..16992)
                     /locus_tag="M878_RS79080"
                     /old_locus_tag="M878_31805"
     CDS             complement(15052..16992)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127600.1"
                     /locus_tag="M878_RS79080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31805"
                     /product="glycoside hydrolase family 9 protein"
                     /protein_id="WP_023551058.1"
                     /transl_table=11
                     /translation="MSEQHNRVIVLAVAGVATAVLAVSCLPPSRPGAGPTAGPPAAVVR
                     VDQVGFAPGETKHAYLMTSRPADRAPFRVLDASGREVLSGTAGPSTGRWNSTYGSVRTL
                     DLSRLTTPGSYQVEVTGPLHATSPKFRVAPAHELFDKVVQDNVRFFTAQRDGAEVDPGV
                     LRRKPSHLADRQATVYDTPVYGEDAERLLAPLKPVGGPVDVAGGWFDAGDFLKFTHTAS
                     YATASLLLAQRTAPAGGAKPAEEARHGLDWLDKMWDASSGTLYVQVGIGVGDTDDGSGK
                     VRSDHDVWRLPEADDAMRVRPGDPDYTIKHRPVFRAAPPGEPISPNLAGRVAAAFALAA
                     QLDAVDAPERARTELEKAARIYALADTSPKGQLVTAFPHGFYPESSWEDDMEFGAAELA
                     LAGEALGDDRTQEWSRQAGHWAKQYLNSDNLGTLGLGDVSALAHADLAKLIDDGRPSGE
                     VSRAQLVADLKRQLDDGQARAARDPFRAGADYTDFDSVPHAFGLATTALLYHRVTGDSR
                     YDSFATQQRDWALGANAWGSSFVIGEGSTFPNCPEHQAANLAGSLTGTGDILVGGVVNG
                     PNDAAKLKELNSFPAMRPCPAGTGDPFSAFNGHGGGYRDHVGAWQTVEAADDFTATALL
                     TFSLFARGVSD"
     gene            complement(17110..18384)
                     /locus_tag="M878_RS79085"
                     /old_locus_tag="M878_31810"
     CDS             complement(17110..18384)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069794.1"
                     /locus_tag="M878_RS79085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31810"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_023551059.1"
                     /transl_table=11
                     /translation="MIADSPAVSRLRRLRWMLTGLFTLTTTVCLAALAAVALAIDARSR
                     ADALDGDLNRRATALARAVYYDQGVLHLGPLREDDLVQGPAAVAVVEWDAADHARQRFA
                     RRPALLPRPAGLSEAGERARHDQETVVERGTAADGRTVRLAAAPVWDDDRIGAVVVAVG
                     DPAAGQRDHDRLVRWLVLGGLGLVTAAAGAGHLLSGRSMRPALRALDQQEQFLSEAAHE
                     LRTPLATLRLVTEAGARSPGESAKALGDATRLVDQMGRLVAGLLTRARVQVGTQRVERT
                     ALRLDQVVEQVVGELPASGAEVTVRAEPTVVHGDPELLAQAVRNLIDNALKHGAAPGER
                     ARVDVVVAEGRVAVRDHGPGVAPAARERVFGRRAAGPGGGTGIGLAIVRWVADLHSGTA
                     RISDAPGGGAVAELVIPRESSGPPV"
     gene            complement(18381..19076)
                     /locus_tag="M878_RS79090"
                     /old_locus_tag="M878_31815"
     CDS             complement(18381..19076)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017236454.1"
                     /locus_tag="M878_RS79090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_31815"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023551060.1"
                     /transl_table=11
                     /translation="MRVLVVEDDRELGRVVLSGLRSAGFAVDLADRLAEADLKLAVSAY
                     DCLVVDRGLPDGDGLALVRDLRRAGARVPVLMLTARDAVADRVAGFDDGADDYVVKPFA
                     FAELAARVGALCRRAEQPRPPVAVVGDLEVDLARRRVRRSGVLLTLTAKEFAVLELLVA
                     RVGQVVSRTDLIECCWDEMAEPASNVVDAVIAQLRRKLGAPAVIGTVRGAGFVIDAGEG
                     PAAGGPVDR"
     assembly_gap    19228..19757
                     /estimated_length=530
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
ORIGIN
        1 acggcgcgca gcatcgggtc ccgccacatc ttgatgatgc tgggcagctt gatcgccagg
       61 gcggcggtca ggacggccgt ggggatccag aaggagacgg agacgtcgct gagggatccc
      121 ggggaatgga gcgccagggt cgaggaatcg agcgccaggg tcaccggtcg gcctctcgtt
      181 ttctgggcgc tccgttcgct tcgtcgcgtc cgcgatagcc gagggtccgt tgcaccgggc
      241 tgagggaacg ttgcgcctgg ccttggggag cgccggtggc ggagtcggtc aggtggggcc
      301 ggaacagggt ggccaggcgg tgcccgaagt cgtccgcctc ggcctcgtcg gcctcccggg
      361 agccgttgcg ggcggccact gtgaggggca tgccgcgcca gccgggcgcg tcggcgagcg
      421 cgcgggccgc cgcgtccccg gccaggtggt ggtgccggtg cccggcgtgc agatgccaca
      481 actcatggcc cagtatgaca agttgctgta ccgcctcggc ccgctcctcc acgatcacca
      541 ggtcgaagtc ggcgaactcc acccacagcc cggtgacttc gatctcgtcc gggaagcgct
      601 cgaagcgcag ctcgaccggc cgtccgccgc gccgtgcgct catctcctcg cacagggccc
      661 ggcacacctc tcgtacgccg gcgggcgccg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     1501 nnnnnnnnnn nnnnnnnnnn nnnnnnnncc cgcgatgccc atgcctcccc cttctggccg
     1561 ccgctgtgga gcccgtccga gggtacgcgc ccgggtgtgt gcgcgtcatg cgatccggcg
     1621 agcgtcgttc aacgggtaac gacccggtga gacttgtgtc cggcctcatg agcttgtgtc
     1681 cgacccattg acgcggaagc gcttcgaatc tacggtctcg cccagctggt caatgtgatc
     1741 gccccgatca tgaccgagcc gggcggcccg gcctggcggc agacgacgtt cttcccgttc
     1801 gcgcaggcgt cgaggtgcgg ccggggcgag gtgctcgacg tgcgggtgga ctcgccgacg
     1861 tacgagacgc ggaagtacgg cgagacggat ctgctgcacg cctcggccgt ccgcgcggcc
     1921 gacggcacgg tcaccgtgtt cgccgtcaac cgcagccgga cggacgccct gccactcgaa
     1981 gtcaccctca ccggaatgga gttgacgacc gtcgccgagc acagcgcgct cgccgacgcc
     2041 gatcccgacg cccgtaacac cctcgacgac cccgggcggg tcgccccgca cccggtcgag
     2101 ggcaccaccg tggcggacgg caccctcacc gccgtactgg agccactgtc ctggaacgtg
     2161 atcagactgg cgtgaccggc agtcctcccg tcgctctgcc gagcagcgtc aggctcacct
     2221 tccccggccc cgacagcgtg gtgaactccg agaggaccgc cagcgcgagg gtgttggtgc
     2281 cccgggtgcg caggacgccg ttcggcagga cgaaggtgtg ctgcgggccc acgttgttga
     2341 tgtactggcc catgttccag ccgttgagga agatctgcgc ccggtaggcg cggtacgggt
     2401 cgtcctccag ggtcaggccg atcgacgcgt cgatgtccgc cgggaccgag agccggaagg
     2461 tggtccggta ccaggtcacg ccctggtacc gggcggcacg cgggaaggcc gtcttctccc
     2521 agtcgtggtc ccggaagccg ggcagatgcc agccctcccg ctcgccgtac aggcccccgt
     2581 tgttcatcgg gccgcgcacg gggtcggggg ccttctcgcc ctggatccgc cagctcaccg
     2641 aaggggaagc ccccttgaag gaggccgccg tcaggccacg ggccgccttg tgggtgtcga
     2701 ggcccttgcc gtcctggtcg tgctgcatac gccgtacgag cacggacagc acatgccggc
     2761 cgggggagcg cagcgcctcc cgcacgggga aggcggcggt cgccgtccaa gtcccctgcc
     2821 tggtggtcgt gttcttgtcc ggtaccggca tccggtgggt gcccagcggt tcgccgtcca
     2881 gccaggccat caacaggccc tgggtgccgg tgctgtaggc gagcgagatc tcctccaggc
     2941 cggtggagtc ggtgaaggtg ccccggtacc agacgtctcc gtagtggaag ccgtagtcgt
     3001 cggcgaagag gaccggcccg ccgtcgggga cgggcgtggt gctgaacgac gacttcttgt
     3061 ccgccgcctt ccagcccgag tcgtcgaaac tgggcccgac ctccgggttc tccgtgcgca
     3121 tccgccagcc gcccagcccg ggcagcctca cctcggggac ggcaggcagc atgccggtgg
     3181 tcatcaggct gccggacagc gtcacccggg tgggcagtct gcgcccgttc cacaccaggg
     3241 tgtcgatgcc gcgcggcccc cacacctcca tgctcgtcgt gttcgtgacg tcacccgtca
     3301 agtggacctc ggagccgcgc agttcgacat ggcgcagcag cgccgggccg tacaccagca
     3361 gggtcccgga cggggtgtcg tacgggaaca cgcgtacggc ggtggcgtcg tcggcgaaga
     3421 gcagcagcag cggcgtctcg gtctcgccct tctgcaccag cacccgggtc agtccgccct
     3481 ggccgagcgg cgtgttcaca tgcagttcgt cggcgccgtc gaaggcccag gcggcctcgg
     3541 ggtccagccg catgacgtcc ggctcggccc ggcacttcag caccagctcg gtcatctcgc
     3601 cgcggcggcc cgagaacagc gcgatgtcct gccgccccgc cgtcacgcac agcacgggct
     3661 cggcggtggc gtacttgagg gtccgcctgc ccagcctcag cccggtcgtc agcagcctgg
     3721 cgtccttgcc gggcacggtg atccgcaccc ggccggcgtc ggtcggcaga tcggtggtga
     3781 ccgcgtgcga gccgtcgttg cgggctacgt agacatgggc gccggtgtcc gggttggtca
     3841 ggtggtagac cttcaggccc tcggcgtgca cgtccgccgc ccggtccagc ttggcgaagt
     3901 cgggaacgcg ctgcaggaga tggccgagct ggtgcatcgg ggcgatcttg ccggtgacgt
     3961 tccgggcctc gtcgatggcg gcgccgtagt cgtacgacgt gtagacgacc ggcgcgggca
     4021 gccagcccca ggaggtcccg ccgaaggtca tgtacacgtt gtgcagggtg agcccgttgg
     4081 cgaggttggt gaggtagaag cggcgctcgt aggcggcgtc ccgggtgcgc cgagactcgg
     4141 cgtacccctt gccgtcgaac caggccccgc cccacgggtc gaaccagccg ccgccgaact
     4201 cgggcacgaa gccgggcgtg gacggtgagg cgccggcccc gcccttcgcc ccgccgggcc
     4261 cgaacgtccc ccagtccggc ggagtctggg acggcgacgg atacccgtcg aagccgtaca
     4321 gccagccgcc cttctcgccg ccggtgtcga acgacccggg cacccagtag ccgttgcgcc
     4381 ccttgtcgtt gtggaacagc ggcacgtcga tgccgtccgc ccgcaccttc ttgtacaggt
     4441 gggacatgta cgcccggccg gtctcgtcgg tgtgggcgtc gtactcgttc tcgatctggt
     4501 acagcaggat cgtgccgttg ccctgcgtga acaggtgctt gcgggcgatc cggttcacct
     4561 gggtcagcca cgcgtcgacg tgccccagat acgccgggtc gtcggtccgg gccgtgccct
     4621 tggccgcggt cagccagccg gggaagccgc cgccgtccac ctcggcgttg atgtacgggc
     4681 cgggccgcag gatgacgtac aggccggtct cggcggccat gcgcaggaac aggtccaggt
     4741 cccggacgcc ggtgaagtcg taccggccgg gtgcggggga gtggtagttc caggccacgt
     4801 agatgctcac ggcgttgtag ccgtgggcgc gcatcttctg cagcacgtcc cgccacaggg
     4861 aggggctcgg cagccggaag ggatgcatct cgccggacca cacgaccagc cgtctgccgt
     4921 ccacgagcag cgagtaccgg tcgtagccga tggtgtgccg ctcgccgtcg gcgctcggcg
     4981 gggcgggcgc cgggccggtc ggcacgctgt gtgccgcgta tgccgagggc gccccggtgc
     5041 cgtcgctgcc gcccagggcg agcccgaggg cggtcgagcc ggccagggca ctgaaatttc
     5101 gtctgctgag cgccaaggtt ggatcctccc gggcgatctt acggggcgcg ggcgaaggcc
     5161 attctccatg cggcgacgtc ccacaacgga ttcatgagga tctcggcacg ggcggattac
     5221 gcggtacggg cggtactgga gttggccgta cggcagggta acgacccccg tgaaggcgga
     5281 ggaaatcgcc gccgcgcagg gcatcccgca caagttcctg gaagggatcc tgggcgatct
     5341 gaggcgggcc gggatcgtcg acagccggcg gggcggaggc ggcggctacc ggctggcgcg
     5401 ggacgcggcc gacgtcacgg tcgcggatgt gatccgggcg gtggacggcc cgatcgtgcc
     5461 ggtccgcggc ggacgcccca cgggcctcgc ctacaccggc aacgctcagc ccctgctccc
     5521 cacagcgcga tacacagatg tgaacggccg gttgtgaatg gccggagttg tatctcccgg
     5581 gggtgagcgg ggctttctac gatgcggagc gcttcacagg ctccacacag accccccaca
     5641 cccgaccatg ggagaaatca tggctggtgg actcctcctg agcggtgccg tggcggcgct
     5701 gctctccacc gcgatacccg ctcagagacc cgccggtggc ccgatcgaca acccgccccc
     5761 ggacaagatc gtcatcgatg tggcgacggt gaacggctcc ggctgccccg agggcaccgc
     5821 ggcggtcgcc gtctcaccgg acaacaccgc cttcacggtg acctacagca gctacctggc
     5881 ccaggccggc ggcaactccg accccacggc cttccgcaag aactgccagc tgaacctggt
     5941 ggtccacgtc ccccagggct tcacctacgc catcgccagc gccgactacc gcggcttcct
     6001 gtccctgcag cccggcgcga gcgcgaccca gaaggcctcg tactacttcc agggctcccc
     6061 gaacaccgtg cccaagagcc atcccttcaa cgcccccttc aatgacaact gggaggccac
     6121 cgacagcacg gactgggccc agctggtctg ggcgccctgc ggggtcctgc ggaacttcaa
     6181 catcaacacc gagctgcggg tgaacgcggg caccaccaat cccgacaagg tcagcttcat
     6241 gaccatggac tcgacggacg gtgacatcag cacggtgtac cacctggcgt ggaagcagtg
     6301 cccgagcgcg tagggcgact cccgccacgc cggtcactcc gagtaggcga tgactttcgc
     6361 cggttctggc cggttcacgc cagcgaaccg tcatccatcg gttgacctgc ggaaacgtta
     6421 gaccaggagt gatgccgatc aggggagcgc gagaggcgca ctgtgagtcc atggactgcc
     6481 ttcgcgcgcc cctgatgtgg ttactcaacg taagcgaggc tctgctagtt ctgtgtacgc
     6541 agcgtgacga cagcagttcg ttgcgaccta cgtgcatgaa agacgaggta gagccatgcc
     6601 cctcgacaca gtgacagcac cggcggcggg cccggagtcg gagcagcggc agcaggagca
     6661 gcagagcctc agcaccgcgg cggcgcgcaa tctcgccacc accaccaagt ccgaacccca
     6721 gatgcagggc atcacctccc gctgggcgac ccgcatgctg ccctgggtga acgtgcccgg
     6781 cgcaacctac cgggtcaacc gccgtctctc ctacaccgtc ggcgacggcc gcgtgacctt
     6841 cgtgaagacc ggctccaagg tccaggtggt ccccgccgaa ctgggtgaac tgcccctgct
     6901 gcgcggcttt tccgacgccg acgtgctcgg cgcgctggcc gacaagttcg tgcagaagga
     6961 gtacgcgccg ggcgatctca tcgtgcaggc gggccgcaag gccgaccagg tgttcctgat
     7021 cgcgcacggc aaggtcgaga agatcggcga gggtccgtac ggcgaagagg ccgtgatcgg
     7081 gctgctggcc gacggggaca ccttcggcgg ccgggtgatg tccggccagg ccaagaagtg
     7141 ggagttcacg gcccgtgccg cgaccgccac gaccgtcctc gcgctgccga tgaccgcgta
     7201 caaggcggtg gccgaccgcc acgaggcact gcgcgcgcat gtgcggcaca tcagctccaa
     7261 cgggcaccgc aagctgaacc ggtccggtga ggcggcgatc gagctcagct cggggcacgt
     7321 gggcgaggag accctgccgc agaccttcgc cgactacgaa gccgagccgc gcgagtacga
     7381 gttgagcgtg gcgcagacgg tgctgcgggt gcacagcagg gtggccgacc tcttcaacga
     7441 gccgatgaac cagacccagc agcagttgcg gctgaccatc gaggcgctgc gcgagcggca
     7501 ggagtacgag ctgatcaaca acgaggagtt cggcctgctc aacaacgccg acttcgacca
     7561 gcggatctcc accttctcgg gcccgccggc cccggacgac atggacgagc tgctgagcat
     7621 gcggcgcaag acccgctgtt tcctcgccca ccccaaggcg atcgccgcgt tcggccgcca
     7681 gtgcaacaag cggggcatct acttcggcgg catcgaactg aacggcaacc acctgcccgc
     7741 ctggcgcggg gtgccgctgc tgccgtgcag caagatcccg atcagcgagc acggcacgac
     7801 gtcgatcatc gccatgcgta ccggtgagga cgaccagggc gtcatcggcc tctaccagac
     7861 cggtatcccg gacgaggtcg agcccggcct gaacgtccgc ttcatgggca tcaacgagca
     7921 ggcggtcatc tcctacctgg tcagcaccta ctactcggcg gccgtcctgg tgcccgacgc
     7981 cctcggcatc ctggagaacg tcgagatcgc ccgcacgaac gggagctgac gacggtgtcg
     8041 ttgatctccc gggtcacggc tcctgccggg tcccacgaca cggcgggcct ggtacgggcc
     8101 ctgctgtcgg ccgggacctc cccgccgacg gccgggcccg ccccgccggt ggccgggtcc
     8161 gcctcccacg agccgcgcct gccttcgggc cgcaccggcc caggcacctc gtcgtcccac
     8221 atccccacgg aaccgtcccc caccccaccc cgaacggccg cactccctct gcccctgccc
     8281 accccagcag tcgcccacca gccgacagcg gtccaaccgc cggtgacggc gcatccgccg
     8341 acggcagtgc ctgcgtcgca gggggcgcgt ctggcggcgg cggtgaaatc gccggaggcg
     8401 gtgccttcac cggagggggc acggccgtct gaggccggga agtcaccggc ggccgggcat
     8461 gcgccgacgg ccgggaattt gccgacggcc ctgcaagcac cgtcggttgg ggccccttct
     8521 ggggctgggc aggtgccgtc ggtcggtggc cctttggcgg ccggggacgt gccgtcggcc
     8581 gggagtcctt tcgtggccgg ggacgtgtcg ggggctgtgc gttcgccggc ggaggtgccg
     8641 ttgtcagggg atgcgggtcg gccggtgctg gtccagttgc cgactggtcc caccggtctc
     8701 ggtacgtcgg cggcggccct tgccctcgcc ggttccggca ccccggcggc agcgcgcgcc
     8761 cgcgtcggtc gtgacgcctc ggcggtgggc cnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8941 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9001 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9061 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9121 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9181 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9301 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9361 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9421 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     9961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtcc gcccgccgtg cgggacgacc
    10021 ccgccctggg ggagagcgtc accgagcggc tggtggaatg gactgaggag atcgggatct
    10081 atccggggcg gtcgggcgag atccgcaagg ccgacttcgg gcggctcgtc atgctggccc
    10141 accccgagtc cgacgacccc gaccggctgc tcgcggctgc caagtgcgcg ctgtcggagt
    10201 gggccgtggg cggccactac gcggaggatc tgggccaacg gctcgccgac gcccgctcgg
    10261 tgatcgacca gtcccacctc ccgctcggct acgcccccag ctcgaagagg tcggtcacgg
    10321 cggacccggt catgcgggcc ctgcgggaca gcctgcgcaa cctccgtacg tacgcgacga
    10381 catcacaggt gcgccggctc cgccacgagc tgggcatcat gctcgacgcc tgcgaccagg
    10441 agggccgctg gcagtcctcc gggcacgtcc cgcccgtcgg ggagttcttg atgcaccggc
    10501 acgagaacag cttcgtaccg cgcatggtgc tcatcgacgc gatcgccgga tacgaggtgc
    10561 cctacggcga gttctccgac ccccgcgtac ggcgtgccct caccaaggcg ggcaccgccg
    10621 gcgtgctcgt caacgacctc tactccatgg ccaaggagga cccggcggac ttcagcctgc
    10681 cccggctgat cgccgccgag gacggctgct cgccggcgga ggccgtcgac cgcaccgtcg
    10741 gcatccacaa cgagctgatg ctcaccttcg aggccgaggc ggccgcgctc gcccggaccg
    10801 gctccccgga actgcgccgc ttcctggccg gcacctgggc ctggctcggc ggcagccgtg
    10861 agtggcacgc gggcagcggc cgctcccacg aggccccgtc gcccgagagc gcgtcccacg
    10921 agcccgcgcc cgagcccgcg cccgagcccg cgcccgagcc cgccgcctga cccgagcgcg
    10981 cggcccctgc gcgcgttccc caccccgctt cacgtaagga acatccatgt ccaagatctc
    11041 cacccagatg gaaagcatcg ccatgcgcga tgtcctgcgc accgaatacc agaagtcggt
    11101 cgcggagtac tggaacaagg agaaggaccc agtcaacatc aagctcggcg aggtcgacgg
    11161 cctctaccac caccactacg gcctcggcga atgggacccc tcggtcctcg ccggcccgcc
    11221 cgagacccgc gaccagcgca tcatcgagga gctgcaccgc ctggagtcgg cacaggccga
    11281 ggtactcctc gaccacctcg gcgacatcac cccggacgac cggctgctgg acgccggttc
    11341 cggccgcggc ggcaccagct tcatggccaa cgcccgcttc ggctgccaca tggacggcgt
    11401 cagcatctcc gagcagcaga tcgacttcgc caacgagcag gcgcggcagc gcggcgtgac
    11461 cgacaaggtc cgcttccact tccgcaacat gctcgacacc cgtctggaga ccggatcccg
    11521 ccgggcgatc tggaccaacg agacgaccat gtacgtcgac ctgttcgaac tcttcgccga
    11581 gttctcgcgc ctgctggagt acggcggacg ctatgtctgc atcaccggct gctccaacga
    11641 cgtcaccggt atgcgctcca aggccgtcag ccggatcgac gagcactaca cctgcaacat
    11701 ccacccgcgc agcgagtact tcagggccct cgccgcgaac gacctcgtgc cgatccaggt
    11761 ggtggacctg accccggaca cgatccccta ctgggagctg cgcgccaagt cctcggtggc
    11821 taccggcatc gaggacccgt tcctcaccgc ctacaaggag ggcagcttcc actacctgct
    11881 catcgcggcc gaccggatct gacgttacgg cgtgcgggcc catggacgca tgatcgtggg
    11941 cctgcacgcg ctccccgggt gcttcccgag ccccgtgtcg gggctctcgg cggtgccgtt
    12001 gactttgttg gatgggagac gacatgagaa cagatcgccc ttgggccaag gccgttgtca
    12061 tcggtggcag ctacgcgggc ctggtgaccg cacgcgtcct ggccgacttc ttccgcgagg
    12121 tcatcctggt ggaacgggac gccgtggacg aggacaccgg cgtccatccg ggcgctccgc
    12181 agggctatca cgcacacgcg atgctcgcca agggaggtca gatcctggag cggctgttcc
    12241 cggggctgcg cgacgagttg cgcgcggcgg gagcgccggt gttcgactac ggagagggta
    12301 tcgacttcct gctgcccgtc ggactcgcgc cacggcggcg tacgggcgtc cgcatccaga
    12361 ccttcacccg cgacgagctg gaacgccgcc tgcgccgcaa ggtgctcgcg cttccccagg
    12421 tcacactggt gccgtccacc cagtgcacgg gcctgacccg ggacccctcg ggccgggtga
    12481 ccggcgtgac atgccgctcg cagcacacgg acgcctcgga ccccgcggcc gcggaaccct
    12541 tcgagctggc cgccgatctg gtcatcgacg cctccggacg gaccagctcc ctgacggact
    12601 ggctgggcgc gatggggatc acggtgcggc ccaaacggac cgtgaaggcg aaggtcacgt
    12661 acacgtcgat gaacttcgac cggccgcaca cgagtcagcc cggccacccg gactactacg
    12721 tcgcctacca gatgctgttc gcccccagcg tgccccgggc cggggtcctg ctcgccgtgg
    12781 agcgcaaccg ctggacctgc tcgctgttcg ggttccagga ccagccgccg atcgacgacg
    12841 agggatatct gaagttcgcc gagagcctgc agaacccgcg cctcgccgag cagatcggcc
    12901 ggcgcaccgc ccaggagccc acccggcgct acaccaacgc cgacaaccag tggcggctct
    12961 atcacaccgt caaggactgg ccggaccgcc tgctcgccgt cggcgacgcc gtctgcgtct
    13021 tcaaccccgt ctacggccag ggtctgacgg tggcggcgat ggaggcggag ctgctgcagg
    13081 gcatgctgaa gcggcacagc gcgtcggggc ggctggacgg cctcgccggc ggtttccaga
    13141 agaaggtggg ccgcttggtg ctgggcccat ggacgctgtc caccaactcg gacctgatgt
    13201 ggaacccgga gggtcagccc ctcgccgcgc gcttcgccca ctggtacaac acgcgtctgt
    13261 tccacgtggc ggtgaaggac gcggccgtat gggcgaggtt cgtacgcgtg gtgaacatgg
    13321 tggcctcacc ggccgtcctg ttccaccccc tggtggccct gaaggtcctg acggtcactc
    13381 cccggcgtac gtgacgaacg ccgaccaggc ggtgggggag agggcgagct gagggccttc
    13441 cttggccttg gagtcgcgga cgtggatggt ggccgggcag acggccacct ctacgcaatc
    13501 gtctccggag ccgctgctgt acgtcgactt ccgccagttc agggcgacct cgatgcagtc
    13561 gccgtctccg ctgctggagt agctcgactt gagccagttc agggcgactt cgacgcagtc
    13621 accggaaccg ctgctgctgt agctgctctt gaaccacgcg agttcggagg tgctcatagg
    13681 tctcctcgga tccgttgcag caggctcacc gagtcctgaa gcggcagagc ctgtgaacgc
    13741 atcctggcat accggccgta gagacggctg accacctttg cgtcggagag gagcattccg
    13801 cactccggtg cttccaagta ggcgaaccac ttgttgctcg ggtcctccag aagttgcatg
    13861 ggcccgtgca gtccagcgtg tgactctcgc gccaagggca tgatctggag ttcgacgttc
    13921 cgcaactgcg cgatctccag cagctggtcg acggactcac gcgtgatatc cacgcctccg
    13981 gtaccacgga gaagtacctg ttcctcgatg atgaagctga aggcgctgtt ctggcgctcc
    14041 cgcagcagcc gctggcggtt ggcccgagca acccagttgg cctcgatctg ttcgtcggtc
    14101 aggatcggca actcgtccat gaacagctga cgtgcgtatg cctctgtctg tagcagtccc
    14161 ggaatcattc ggcactcgta ggtgtagaga ctgatcgcct gcttctccag ccccgcccac
    14221 cgtcggaacc aagaagccag ccccgcctct cgctccagat gctccgccgc cctcctcaac
    14281 gctcccgtgt ttcccagtgc cttctccgcc gcctccacga agtccgggtc cggcatcctc
    14341 ctccccaact cgatggatgc gaccgtgtgt ttggagaacc ccacaaggtc cccgagttcc
    14401 tccctgctca gcccgtgata ctcccggagg gcctgcaaga ccgccccgaa cgtccgcaaa
    14461 ctgcccgacg actccggctc accgccgttt cccgtaccca tgccgcacat ggttacgacc
    14521 tgtcacaagt actgtccaga acgtgaccgc gtacgctgcg cgagcgtacg cgggccgaac
    14581 ctggtgaagt gccgttcaca tcaaccacat tgggccccat gaccgcacca cccctcccca
    14641 cccacaccgt cactcagcgc ctcagttcca ccccgcgcgg cgcccgcctg gcaaggcatc
    14701 tcacattggc ccagctggac acctggggca tcccgcacgg caccgacacc gccgaggcgg
    14761 tcgcggcgat cgtcgccgag ctggccgcga acgccgtcac ccacgggcgc gtacccggcc
    14821 gggacttcga actgcggctg gtccggctgg tcgggagcat ccgcgtcgag gtgagtgaca
    14881 cgtacgacga acgacggccg cccgggcccg aggacgtgac cgagcccgcg ccgctcgcgg
    14941 aggcggggcg tgggctcgtg ctggtggacg cgttggccga tcggtgggag gtggtcgacc
    15001 gcgacccgcc cggcaagacc gtgcgggccg aggtcgacat gccgccgtgg ctcagtcgga
    15061 gactccgcgt gcgaagaggc tgaacgtcag caatgccgtc gccgtgaagt cgtcggccgc
    15121 ctcgacggtc tgccaggcgc cgacgtggtc ccggtagccg cccccgtggc cgttgaaggc
    15181 ggagaagggg tcgcccgttc cggccgggca cgggcgcatg gccgggaagg agttgagttc
    15241 cttcagtttg gccgcgtcgt tggggccgtt gaccacgccg ccgacgagga tgtcgcccgt
    15301 gcccgtgagg ctgcccgcga ggttggcggc ctggtgctcc gggcagttcg ggaaggtgga
    15361 cccttctccg atgacgaagg acgatcccca ggcgttggcg cccagcgccc agtcgcgctg
    15421 ctgggtggcg aaactgtcgt aacgggagtc gccggtgacc cggtggtaca gcagcgcggt
    15481 ggtggccagg ccgaaggcgt ggggcacgga gtcgaagtcc gtgtagtcgg cacccgcgcg
    15541 gaaggggtcc cgggccgcgc gggcctggcc gtcgtcgagc tgccgcttga ggtcggcgac
    15601 cagctgcgcg cggctgacct cgccgctcgg ccggccgtcg tcgatcagct tcgcgagatc
    15661 ggcgtgtgcc agggcgctga cgtcgcccag tccgagggtg ccgaggttgt ccgagttcag
    15721 gtactgcttg gcccagtggc cggcctgacg cgaccattcc tgtgtccggt cgtcgcccag
    15781 agcctcgccg gccagggcca gttccgcggc tccgaactcc atgtcgtcct cccaggacga
    15841 ctcggggtag aaaccgtggg gaaacgcggt gaccagctgg cccttcggcg aggtgtcggc
    15901 gagtgcgtag atccgggcgg ccttctccag ttccgtgcgt gcccgctccg gggcgtctac
    15961 ggcgtccagt tgtgcggcca gcgcgaaggc cgcggcgacc cgccccgcga gattggggct
    16021 gatgggctcg ccgggaggtg cggcccggaa gaccggccgg tgtttgatcg tgtagtcggg
    16081 gtcgccgggc cggacccgca tcgcgtcgtc ggcttcgggc agccgccaca cgtcgtgatc
    16141 ggaacgcacc ttgccgctgc cgtcatcggt gtcgcccacg cctatgccga cctggacgta
    16201 aagggtgccg gaggaggcgt cccacatctt gtccagccag tccagcccgt ggcgggcctc
    16261 ctcggccggc ttcgcaccgc cggccggggc cgtgcgctgg gccaggagga ggctcgcggt
    16321 ggcgtacgac gcggtgtgcg tgaacttcag gaagtcgccg gcgtcgaacc agccgccggc
    16381 gacgtcgacc gggccgccca cgggcttgag aggtgcgagc agccgctcgg cgtcttcacc
    16441 gtagacgggg gtgtcataga ccgtggcctg ccggtcggcc agatgcgagg gcttgcgccg
    16501 cagcacgccg gggtccactt cggctccgtc gcgctgcgct gtgaagaagc ggacgttgtc
    16561 ctggacgacc ttgtcgaaca gctcgtgggc gggcgccaca cggaacttcg gcgaggtcgc
    16621 gtggagcggg ccggtgacct ccacctggta gctgccggga gtcgtgaggc gggacaggtc
    16681 cagggtgcgg acggagccgt aggtgctgtt ccatcgcccc gtggagggcc cggccgtgcc
    16741 ggacagcacc tccctgccgg aggcgtcgag tacccggaag ggcgcccggt cggcggggcg
    16801 ggacgtcatc aagtaggcgt gcttggtctc gccgggtgcg aagccgacct ggtcgacgcg
    16861 gaccacggcg gcgggcggac cggcggtcgg gccggctccg ggacgggacg gcggcaagca
    16921 ggagacagcg aggacggcgg tggcgacacc ggcgacggcc aggacgatca cgcgattgtg
    16981 ttgctcggac atgccagaag gctgccgacg gcatcatgag gaaatcgtga ggcggcccgc
    17041 acagcccaca tcgcccgcgc agcgcgtaca gcgcacacgg ctccgcatcg cccctgcgcc
    17101 atcgcggcgt cacacgggcg gaccggatga ttcccgcggg atgaccagtt cggctacggc
    17161 cccgcctccg ggggcgtcgc tgatgcgcgc ggtaccggag tgcagatcgg ccacccaccg
    17221 cacaatcgcc agcccgatcc ccgtaccccc tccaggtcct gccgcccgac ggccgaagac
    17281 ccgctcccgc gcggccgggg ccacccctgg accgtggtcg cgcacggcga ccctgccctc
    17341 cgcgaccacc acatcgaccc gggcccgctc tcctggggca gccccgtgct tgagggcgtt
    17401 gtcgatcagg ttgcgcaccg cctgggccag cagttccgga tcgccgtgca cgaccgtggg
    17461 ctcggcccgc accgtcacct cggcgcccga ggccggtagt tcgccgacga cctgctcgac
    17521 gacctggtcg agccggagcg ccgtccgctc cacccgctgc gtgccgacct gtacccgcgc
    17581 acgggtcagc aggccggcca ccagccgccc catctgatcc accagtcgcg tcgcgtcgcc
    17641 cagcgccttg gcggactccc ccggtgaccg cgcaccggcc tccgtgacca gcctgagcgt
    17701 ggccagtggg gtgcgcagct cgtgggcggc ctcggacagg aactgctcct gctggtccag
    17761 ggcccgcagc gcgggacgca tgctccgccc cgacagcaga tggccggcgc cggccgccgc
    17821 ggtcacaagc cccagaccgc cgaggacgag ccaccgcacg agacggtcat ggtcgcgttg
    17881 ccccgccgca gggtcaccta cggcgacgac caccgcaccg atccggtcgt cgtcccacac
    17941 gggtgccgcc gccagccgga cggtccgtcc gtcggcggcg gtaccccgct ccacgacagt
    18001 ctcctggtcg tgtctggccc gctcaccggc ctcgctcagc ccggccggcc gtggcaggag
    18061 cgcggggcgg cgggcgaagc gctgccgcgc gtggtccgcc gcgtcccact ccaccaccgc
    18121 caccgcggcc gggccctgga ccaggtcgtc ctcgcgcagc ggccccaagt gcagtacgcc
    18181 ctggtcgtag tagaccgcac gggccaaggc cgtagcccgc cggttgagat cgccgtccag
    18241 cgcatcggcg cgtgatcggg cgtcgatcgc cagcgcgacc gcggccagag cagccaggca
    18301 cacggtggtg gtcaacgtga acaggccggt cagcatccac cgcagccgcc tcagccgcga
    18361 caccgccggg ctgtcggcga tcaccggtcc accggtccgc cggccgccgg cccctccccg
    18421 gcatcgatca cgaaccccgc accgcgcacg gtgccgatca ccgccggggc gccgagcttg
    18481 cggcgcagct gcgcgatcac cgcgtccacc acgttcgatg ccggctccgc catctcgtcc
    18541 cagcagcact cgatcaggtc ggtgcgcgac accacctgcc cgacccgggc cacgagaagt
    18601 tccagaaccg cgaactcctt ggcggtgagc gtcagcagga cgcctgaacg ccgcacccgg
    18661 cgtcgagcca ggtccacttc gaggtcaccg accaccgcca cgggcgggcg gggctgctcg
    18721 gcgcgccggc agagcgcacc gacgcgcgcg gccagctccg cgaacgcgaa gggcttgacc
    18781 acgtagtcgt cggcgccgtc atcgaacccg gccactcggt ccgccacggc atccctcgcc
    18841 gtgagcatca gcacgggaac ccgcgcaccc gcccggcgca ggtcccggac cagagccagc
    18901 ccatccccgt cgggcagccc cctgtcgacc accaggcagt cgtacgcact gacagcgagc
    18961 ttgagatccg cctccgccag ccggtccgcg agatccaccg cgaacccggc cgaccgcaga
    19021 cccgacagca ccacccggcc gagttcccgg tcatcctcca ccaccagcac gcgcatggcc
    19081 ttgagcgtag acggccacag ggaagcggtg tcacgcggcg gtgctccggc cgccgacgcc
    19141 tccggccggt caggcccccg cgcgctcggc cagctctggg cgttcggcca gccggtggcc
    19201 gggccgggac aggcctgtgg cgggggcnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19621 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19681 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    19741 nnnnnnnnnn nnnnnnntac cgcgcacctg ggccgccgtc aggccgccgc gtgccgggac
    19801 gcccggggga gtgggggcga tcgcggcggg ggccggcaca ggcacgggca ccggggcggg
    19861 tacgggggtc ggcgagggga agggtgtggg cgccggcagg ggagccggga ccggctgggg
    19921 agccgggacc ggtaccgggg tcggctgagg cgccgcaggc aggggctggg ctgccgccgg
    19981 catcggcatc ccggcgccgg gtgggggtac ggcggcgggg agcggcatgc cggtgccggc
    20041 ggccggagcg ggagcggcgg tcatggcctc ggcctgcgcg gccaggcccg gtacgccgcc
    20101 tccgttggtc tggctcatca gccggtccac cgccgccgta cccgagctgt agctggtccc
    20161 ggtgcccagc tcgggtacgg cggctcccct cctggacccg tagagcacct gctccaggcc
    20221 ggacaccagg cgacgcacgt cgacctgggg gcgcaccacg agtctcagga agcggctgga
    20281 ggaaccgatc ttgttgccgc actcgcggac caggatccgg tgctcggtga gcatccggtc
    20341 ccggaccacc gtgccctcgg ccccgacggg cagccgtacg aagaggaagt tcccttggga
    20401 ggggtagacc gtgagcccgg ggagcgcgga gaggtggctg gtcatctcca ggcggtcgcg
    20461 gcggatctgc agcaggctct gcgcgtactc cgcaccgtgg tcgcgcagca tgaacaccac
    20521 gtgctcggcg agggagttga ggttccactt cgggagcatc gaccggatgc ggcccgccag
    20581 cgccgggttc gccaccaggt agccgaagcg gatgccgtgc aggccgaagc ttttgccgag
    20641 gctgcgcagg acgatgacgt tggggcggag catggcctcc tggacgacgc tcgggtcggc
    20701 ctccgcgtcg gcgaactcca ggaaggactc gtccacgatc accaggtcca ggtccgccat
    20761 cgcgtccatg aactgcacca ccgactgctt gcgcagatag ccgccgtcgg ggttgttcgg
    20821 gttgcagagc accaccgcac gggtgccgcg ccgccggatg aactcggcgt actgggcgag
    20881 gtccagggcg aatccgctcg cctcctggag cgggaacatg tcgacccgct tgcccgtctc
    20941 catcggctgg tcggtccagc ggccgaaggt
//
