LOCUS       NZ_CM002285            22569 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5326558
            Orig. end                         :: 5349127
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22569
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="28"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22569
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22569
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12569](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12569)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(19..34)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            68..913
                     /locus_tag="M878_RS72805"
                     /old_locus_tag="M878_24735"
     CDS             68..913
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /GO_process="GO:0008150 - biological_process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013002833.1"
                     /locus_tag="M878_RS72805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24735"
                     /product="TIGR03619 family F420-dependent LLM class
                     oxidoreductase"
                     /protein_id="WP_031225539.1"
                     /transl_table=11
                     /translation="MRIAVTIFLTDETIAPVRLARELEQRGYAGLYLPEHTHIPVERTT
                     PYPAGGELPREYGRTLDPFVALGQAVAVTERLGLGTGITLVAQHDPIALAKQIATLDHL
                     SGGRFTLGLGYGWNVEEAADHGVTWRTRRELVRDRVRLMQALWSGEPTPYDGEFGGVRA
                     SDAYPKPAQKPRGPVTGPRTLVGGAAGPKLFAHIAEYADGWLPIGGRGLTESLPVLRSA
                     WTAAGRDPSALQIVPYAVLPAPGKLAHYAELGIEEVVLQLPPAGEAEVLRVLDEYASFL
                     "
     misc_feature    complement(944..957)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.73"
                     /tool="antismash"
     misc_feature    944..957
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.02"
                     /tool="antismash"
     gene            962..3547
                     /locus_tag="M878_RS72810"
                     /old_locus_tag="M878_24740"
     CDS             962..3547
                     /EC_number="2.5.1.147"
                     /EC_number="4.3.1.32"
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673305.1"
                     /locus_tag="M878_RS72810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24740"
                     /product="bifunctional FO biosynthesis protein CofGH"
                     /protein_id="WP_023549511.1"
                     /sec_met_domain="PF04055 (E-value: 2.6e-15, bitscore: 56.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSATSGTGPTENSMRRALKRARDGVALDVAEAAVLLQARGEAL
                     ADLAASAARVRDAGLEQAGRPGVITYSKSVFIPLTRLCRDKCHYCTFVTVPGKLRRAGH
                     GMFMSPDEVLDIARKGAALGCKEALITLGDKPEDRWPEAREWLDAHGYDDTIAYVRAVS
                     IRILEETGLLPHLNPGVMTWTDFQRLKPVAPSMGMMLETTATRLWSEPGGPHYGSPDKE
                     PAVRLRVLEDAGRSSVPFTSGLLIGIGETYEERAESLFALRKVSRAYHGIQELIIQNFR
                     AKPDTAMRGMPDAELDELVATVAVARHIMGPSACLQAPPNLVDSEYERLIGAGIDDWGG
                     VSPLTIDHVNPERPWPQIEELTERSRAAGFELRERLCVYPEFVRRGEPWLDPRLRPHVA
                     ALADPETGLAREDAVVEGHPWQEPEEAFVPTGRTDLHRTIDTEGRTTDRRDDFDEVYGD
                     WEALREAAAPGMAPERIDTDVRQALRTAADDPTRLTDAEALALLHADGPALDALCRVAD
                     DVRKSAVGDDVTYIVTRNINFTNVCYTGCRFCAFAQRRTDADAYTLSLEQVADRAQQAW
                     EVGAVEVCMQGGIHPDLPGTAYFDIAKAVKDRVPGMHVHAFSPMEVVNGATRTGMPIRE
                     WLSAAKEAGLDSIPGTAAEILDDEVRWVLTKGKLPTATWIEVITTAHEVGIRSSSTMMY
                     GHVDQPRHWLGHLRTLARIQRETGGFTEFVTLPFIHTNAPVYLAGISRPGPTTRDNRAV
                     TAMSRLLLHPWIPNIQTSWVKLGAEGAAEMLRSGANDLGGTLMEETISRMAGSSYGSYK
                     SIRDLVAVAEAAGRPAKPRTTLYGEVSAERQRAAGASDGHLPELLPVLD"
     gene            3616..4179
                     /locus_tag="M878_RS72815"
                     /old_locus_tag="M878_24745"
     CDS             3616..4179
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018567145.1"
                     /locus_tag="M878_RS72815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24745"
                     /product="hypothetical protein"
                     /protein_id="WP_023549512.1"
                     /transl_table=11
                     /translation="MAARLPSWAWVTGLTVGATAAVVALAVQADHGPHPTAAVASPSAS
                     ASAGAHASTRPKPPAPPVLPAASGVGRRIVYSIGGKRVWLVDATGKATRTFTVWPGTVN
                     PQPGRYSIIKRIQSLKGSDGVEIEHVMYFTVASGVNIAFSNALDGSSPPPADGKKLGGI
                     RMDKEDGAALWSFGDQGTGVAVVN"
     gene            complement(4172..4690)
                     /locus_tag="M878_RS72820"
                     /old_locus_tag="M878_24750"
     CDS             complement(4172..4690)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673302.1"
                     /locus_tag="M878_RS72820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24750"
                     /product="DUF2165 domain-containing protein"
                     /protein_id="WP_023549513.1"
                     /transl_table=11
                     /translation="MTTTPTRHSGLRPAAGVLTGILALYIALVAFGNITDFGTNQQFVR
                     HVLAMDTTFKDHDLMWRAVSSTGLQDTAYVLIIVWETASALVLIWGTWLWAWRKDDLAR
                     RISTYGLLMLLLLFGAGFIGIGGEWFSMWQSKTWNGLEAATRIFTLSGVALIVNQLPSR
                     RGEVRQDAS"
     gene            4776..8102
                     /locus_tag="M878_RS72825"
                     /old_locus_tag="M878_24755"
     CDS             4776..8102
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1272: TPR
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121696.1"
                     /locus_tag="M878_RS72825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24755"
                     /product="ATP-binding protein"
                     /protein_id="WP_023549514.1"
                     /transl_table=11
                     /translation="MAQARPSMQELIGRRRRSGFVGRSDERAAFRENLDLPPEDERHRF
                     LFHIHGNAGVGKTFLVRELEQIARERGALTVYVDEGVGSVPEAMAVVSRECARQGTEFK
                     KFDRALASYRERRHEAEAVAAGLDSAQDGPSPVTATVARAGLAGLGLIPGAGPFVGAVD
                     AAQLAQYADRLRRGLSARFSSQDDVQLVLSPERALTPRLLDELTDVASAVPWIILFFDT
                     YERTGPFLDGWLHGMMTTDDYGALPANVVVVTAGQHPFDRARWGGFADFMTEIPLGPFT
                     EAEARGLLTERGVVAEPVVTEVLRLTGGLPLLVSTLAEQQPADLEDIGDPSATAVERFL
                     KWEQDPVRRAVALACALPRGLDMDVFRAAVDSPDEEADSLFAWLRGLPFVDDRGDRLRY
                     HDLVRETMLRLLRRRSPQGWKERHERLATVYGRWCEEAADGIRPAYTWEHERWRELRLE
                     QAYHLVCARPRTEVAQTLMSVVEACWWDQVDGRRWARMLEEAGTVADDADLRDWGRRLR
                     DALADDQHGVSRTVDLLLSRPGLDVSGRALAHGLRGRQLRRGGEHRRALAEYDRAVALS
                     ERASLPEMHLASLYFGRGVTCQMLDDFPAAMADLDRADALCPDDAEILYGRGETHRLAG
                     RLEEAVTEFDRALAVDPADPDSLSSRAACLHALGRLDEALADFDRALGLAQGFLWALVR
                     RARLRRDRGEWEEAFADLDRAVTLAPESAWVASERGDAYRLAGRFEEAVTELGRALELK
                     LDYASALAGRGVALRELGRIEEALADFDRAVELIPEYAWALGHRAICKQQLQDSEGELT
                     DLRRAVAADPDLGWIHTALGDAHWRADQYREALPFLQRALELGPDDAWALALLGAAYRG
                     LGNYPEAFRCLDRAVALDSGYGWALSQRAMAAMAVGRTERALADLDRCIALETRVDWAR
                     EQAVDLLMRCGRWPEAMERLAEADRLGLPEEALEAQRAEAYRHARQWAAARRQAERIRV
                     RSPAAGIFELALTVGGSDGASAARSLWREAERWLQSVDLEASDRALTRCLVSCALGDWR
                     IADATLTHLLAEEQDWDDLALLASVLTELMAAPGADRARMAPRLAAVEAARDAVQARYA
                     E"
     gene            complement(8169..10004)
                     /locus_tag="M878_RS72830"
                     /old_locus_tag="M878_24760"
     CDS             complement(8169..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="M878_RS72830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24760"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023549515.1"
                     /transl_table=11
                     /translation="MTGPTAPHAERADAAEGDGSTLAAVDTMYRLTAGHRGAIAVATVL
                     TLVGSALGLAQPLVAKDVVDASGRGQVIWPLLGLLGALFVVEAAAGAAGRFLLERMGEG
                     VVRQLRHGLVGRLLRLEMREYDRHRGGDLISRVTADTTVLREVVSQALVDLVTGSMVSA
                     GAIILMAWLDPLLLLLVAVTVAAAAVVVASLLTGIRGASAHMQAAVGAVAADLERALGA
                     LPMVRVHRAEQREAAGIGARVDAAYGSGVRAAKLAAVMSSAVELAVQGSFLIVLVVGGL
                     RVSGHAGSLGDLVAFLLYASYLVLPLSSVFRAVGLVQRGMGAYQRVEEALRLPVEPTTA
                     QIPADHAPAPRPPATRERPALALHDVHFGYDPRRPVLRGVSFTVPQRRHVALVGRSGAG
                     KSTVFALVARFYEPDAGTVLFDGRPAAELTRDACRRGIAVVDQNTHVVHGTLRDNITYA
                     VPDAPEAEIRRVVELVRLEEVVDRLPGGLAAVIGERGSTLSGGERQRVALARALLARPA
                     LLLLDEPTSHLDAINEAALTTVMKDVAQECALLVIAHRLSTVQHADHIVVLQDGRTAAV
                     GRHEELLTGSALYRELAASQMLRPGELRPPPAGGR"
     gene            complement(10001..10438)
                     /locus_tag="M878_RS72835"
                     /old_locus_tag="M878_24765"
     CDS             complement(10001..10438)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988507.1"
                     /locus_tag="M878_RS72835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24765"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_031225541.1"
                     /sec_met_domain="PF13471 (E-value: 4.1e-24, bitscore: 83.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPLPRRLAARLVLLPALAIALLPPRRIRAVLGI
                     LRRGARPATAAEARNARDAMCAASLRCAGPKGCLPRSLGAALLCRLGGTWPTWCTGVRI
                     VPPFTAHAWIEAEGGPVGEGAPEGYFARLVAVGPLPRATDR"
     gene            complement(10435..10689)
                     /locus_tag="M878_RS72840"
                     /old_locus_tag="M878_24770"
     CDS             complement(10435..10689)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988506.1"
                     /locus_tag="M878_RS72840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24770"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_023549517.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-23,
                     bitscore: 82.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.9e-16, bitscore: 59.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLRFGDNVSTAQTDYGTVLLDERGGAYWELNPTATLVVRTLFEG
                     GEEADAAAALVQEFDIDEAQALRDVEALVRQLRDSGLAS"
     aSDomain        complement(10441..10683)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M878_RS72840_Stand_Alone_Lasso_RRE.1"
                     /evalue="3.70E-26"
                     /identifier="RREFam002.1"
                     /label="M878_RS72840"
                     /locus_tag="M878_RS72840"
                     /protein_end="83"
                     /protein_start="2"
                     /score="82.0"
                     /tool="antismash"
                     /translation="LRFGDNVSTAQTDYGTVLLDERGGAYWELNPTATLVVRTLFEGGE
                     EADAAAALVQEFDIDEAQALRDVEALVRQLRDSGLA"
     gene            complement(10719..12569)
                     /locus_tag="M878_RS72845"
                     /old_locus_tag="M878_24775"
     CDS             complement(10719..12569)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988505.1"
                     /locus_tag="M878_RS72845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24775"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_023549518.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.4e-45, bitscore:
                     155.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELHASAGTGPGDAHFAVFPDRADAAAVARSFARPGSRTLAHAS
                     GRPWLVGHWHDDEVVTAGAGGACVAVVGCCPADADELRRRTARLRDLAELDALARSLPG
                     SFHLVGALDGRIRVQGTASGLRLVFHAEIDGVQVAATRADTLAAALGLDPDIEELAVRL
                     LWPAPYPLFETSMWRSVTAVAPQDAVVVAADGRTVRHTRWWTPPEPVRPLAEAAPQIRT
                     ALEEAVGARTRQGGVVSCDLSGGLDSTSVCFLADRSPAHVVASTWPGRDPADTDLHWAE
                     RAMGHLPDVEHVVWDADASPLVYEDLLGIDDLLDEPTIGVMDRSRVLHHLPGLTARGSR
                     LHLTGIGGDHVAWCSDAYYHRLLRTRPLFALRQLRGYRALWHWPLGGTARALADSRPYG
                     KWLADAAGRLRGPLPPSVTTSLGWGMTPRLFDWVTPETERMARRALLAAAATAAPLHPD
                     RGLHTDLEQIRSCTRIIRQWDRMAALAGLPMASPFLDDRVIEACLAVRPSERVTPWRYK
                     PVLTAAMRGVVPEDCLRRANKATAAMDAANGLRDHRADLLALWEDSRLAELGLVDGAEL
                     RRLAQRPASKGLSDAILYSTIAAEVWLRGLDRSRTRAAHP"
     gene            complement(12596..12706)
                     /locus_tag="M878_RS96600"
                     /old_locus_tag="M878_24780"
     CDS             complement(12596..12706)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638602.1"
                     /locus_tag="M878_RS96600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24780"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_023549519.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGTFRKETGLLQRSGNDRLIFSKN"
     misc_feature    12944..12957
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    complement(12944..12957)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            13229..14344
                     /locus_tag="M878_RS72850"
                     /old_locus_tag="M878_24785"
     CDS             13229..14344
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003974547.1"
                     /locus_tag="M878_RS72850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24785"
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_023549520.1"
                     /transl_table=11
                     /translation="MGATSGAVWGRAEQQDFRSRVRGTLLGAAVGDALGGPADPLSLEE
                     IRATYGPEGLLDLAFGHGRRGTVTHHTQLTLFTLDGLIRAQVRRDTGAWHPPTDLHRAY
                     RRWAATQRDWGPDERRKDDGWLAREEWLYARREPTRALLVGFGDDTLGTLESPKNPGEL
                     GPEAVARSAPFGLLVGWEPQLVAQLAVECATQSHGHPIAYLSAGAYAVIVHALARGESL
                     DGAVQRALALLAARPGHQPVSDALQHALGAVRQGIPSPTRVEELAGDGTADGLLAASVY
                     CALVGEDVRHGLCLAVNQGGPSAAAGALTGGLLGALHGETALPPGWLTELEGRATMLEL
                     ADDFAMEMTQGPALHGPAGSAPGWLARYPRA"
     gene            complement(14394..15935)
                     /locus_tag="M878_RS72855"
                     /old_locus_tag="M878_24790"
     CDS             complement(14394..15935)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014673300.1"
                     /locus_tag="M878_RS72855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24790"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_031225542.1"
                     /transl_table=11
                     /translation="MNSLDWAVLIGYFGVMVAIGVWSHKRVDNVSDFFTAGGKMPWWLS
                     GISHHMSGYSAVMFTGYAGIAYTYGVTSFVTWSFPIALGIAIGSRLFAPRINRLRSRLH
                     VASPLEYLKNRYNLSTQQALAWSGMLLKIVDVGAKWAAIATLLSVFTGVSLNQGILITG
                     AITAVYCTIGGLWADALTELGQFVIQLLAGVSMFVAVVLKLNDKHIGFFDAWSQPALHG
                     HGKPLVGPYGTVFLFAFLFIKLFEYNGGMLNQAQRYMATGSAHEAERSARLSAILWLVW
                     PVVLFFPMWMSPLLVHAQKPDGSDSYGLMTEQLLPHGLLGLVIVGFFSHTMAMCSSDAN
                     AISAVFTRDVAPVLSARARAWSARSGLIAARVTTVLFLGLSMAVATQVNSPTFKDIITV
                     VIKWVAGLMGPIAIPMMLGLLRPFRRSGPTAALTSWAAGLLAFWLVNYPVSWNVSGGVA
                     LQYQVSVPLAVSLALYIVIGYVKPEDTPERLAIIEKVNTDGDGVAVPAGDVVGAP"
     gene            complement(16073..16861)
                     /locus_tag="M878_RS72860"
                     /old_locus_tag="M878_24795"
     CDS             complement(16073..16861)
                     /NRPS_PKS="Domain: PKS_KR (7-177). E-value: 7.2e-14. Score:
                     44.0. Matches aSDomain:
                     nrpspksdomains_M878_RS72860_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005486082.1"
                     /locus_tag="M878_RS72860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24795"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_023549522.1"
                     /transl_table=11
                     /translation="MPLLTGKTVVVSGVGAGLGHQVAAAVVRDGGNAVLGARTEANLAK
                     SAAEIDPDGTCTAYRATDITDEGQCAALAELARERFGGIDAVVHVAAWDSHFGGLQDAD
                     FATWQSVIDVNLLGTLRMTRACLPSLKAGGGGCVVFIGTQSAVAAPSQVKQAAYAASKG
                     ALTSAMYSLARELGPHRIRVNTVLPGWMWGPPVQAYVQFTAQTEGVPEAEVLGRLTERM
                     ALPELATDGDVADAVVFLSSDRARAITGQSLLVNAGELMR"
     aSDomain        complement(16331..16840)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS72860_PKS_KR.1"
                     /evalue="7.20E-14"
                     /label="M878_RS72860_PKS_KR.1"
                     /locus_tag="M878_RS72860"
                     /protein_end="177"
                     /protein_start="7"
                     /score="44.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVVVSGVGAGLGHQVAAAVVRDGGNAVLGARTEANLAKSAAEIDP
                     DGTCTAYRATDITDEGQCAALAELARERFGGIDAVVHVAAWDSHFGGLQDADFATWQSV
                     IDVNLLGTLRMTRACLPSLKAGGGGCVVFIGTQSAVAAPSQVKQAAYAASKGALTSAMY
                     SLARELG"
     gene            16966..17805
                     /locus_tag="M878_RS72865"
                     /old_locus_tag="M878_24800"
     CDS             16966..17805
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382721.1"
                     /locus_tag="M878_RS72865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24800"
                     /product="hypothetical protein"
                     /protein_id="WP_031225543.1"
                     /transl_table=11
                     /translation="MSEDTRSETYGELAAVGPYGVRPGHALITMVEPHPGHEHAYNRWY
                     EDDHYYAGAMAMPWMYAGRRWVATRDLQLLRSPEKSAVAQPVTAGCYLSTYWITDGRYD
                     HHMKWTVAINKRLNRDARVYHDRTHVFTSFQDHETTVYRDGAAGPRDFHALDHPYAGLV
                     LEVIDSESAGQRAELLRWLRGRHLPKRLAGSPAALVTVFRPTPLPGDRMSYVKQVEGTD
                     TRLTLLWFLERDPRECWEEHFTGLDADVSDSGLGRVELVAPFIPTIPGTDTYVDRLR"
     gene            complement(17836..19731)
                     /locus_tag="M878_RS72870"
                     /old_locus_tag="M878_24805"
     CDS             complement(17836..19731)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020137723.1"
                     /locus_tag="M878_RS72870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24805"
                     /product="hypothetical protein"
                     /protein_id="WP_031225544.1"
                     /transl_table=11
                     /translation="MATAEPTRADDADPGPGSGPRIRASEAGPEGHTDHTGPPDGPTDR
                     DRPGPPDGPGVRPGGLARLLTAAEPLRPRLLRHPVLSITALAGVLHILWFFTFANSGGD
                     LAAQDAWAEFVGRHPDSAYNLAWYGGMHPVSYSVVSPYLMAVLGVRTTMMIAGTVSAGL
                     LTLVLIRSRAVRNPLWASLAGVVALLCNAISGRVTFGLGTMFALGAVAAVFCWPYRWRH
                     KRWAKAAVAAPLAGLSTMASPVSGLFVGLVAVALFLQKRRPGAWALGLAPTVVVAASYF
                     LFPFSGTQPMTIGSVILPLAYGLLCLFLVPREWVTVRLTAAVYSLGVVLVWLVNSQIGS
                     NISRLPMLFAGATLVAALPFTVRKSRRWYVTVLALLGFAGWIGFKSVDDIVHTTPAASW
                     ARELAPLVHQLQKAGAEKGRVEVVPARSHREASALAPYVNLARGWNRQADMERNPLFYD
                     DTLNSANYHEWLQRWAVHFVVLPKDNPDGDGGERERQLLRRGMPYLKQVWGDANWQLFQ
                     VTDATPLAEPDAVVDHAGQGEMTLQVRKAGRILIRIPYSPWLSIVDEHGKSLKAPQQTT
                     AKTYVNTNGCLMETPQDAKGDKWTMLVAPKPGTYRLAAPYQLPRGTPCPDVFKTR"
     gene            complement(19931..22318)
                     /locus_tag="M878_RS72875"
                     /old_locus_tag="M878_24810"
     CDS             complement(19931..22318)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493274.1"
                     /locus_tag="M878_RS72875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_24810"
                     /product="D-alanyl-D-alanine carboxypeptidase"
                     /protein_id="WP_031225545.1"
                     /transl_table=11
                     /translation="MAGESPDRSKQRESSAEPTSGSAGPVPETRDPRLAVAREKDSAQA
                     SADTATKILSIPDAPKPDTKETPAEDAALRQAVSAWVRTAAPANNSDTPANTPPTTPSA
                     TAGTETEAETAGARNGTAEEGKPETTDADADAKGYAEAESAGAKPDTDVKAGAKADAAP
                     KAGDDGETADAGAAAEARTRAEAGSEAAPVAEAGSDGDAEAKAEAGSGAEPKAEAEEAK
                     DGPKARGGSENEDRPEDANGGDAPQGPPAADDESRTGGAGGNTDADGEAEADAPHAEAP
                     QAKAAVDQPTAVFKTVKPKQVDQPTTMLKLGGRTNTPKTPESESERTSKFVALKNDMAP
                     ATKPPAAKPDVTTPVPQVGPERTTQQPLPPKPPLDLLAELTNTPPPPETAVRTIVRRVK
                     IWTPLVLLLAVIFAVVQAVRPLPAPALGLTAKDSYTFDGAGANLPWPGEGQGWMDVDGI
                     GTMSRFGKQTPVAIGSVAKTMTSYIVLRDHPLKPGQEGPKITVDPQAEKEGGYSKSGES
                     TVNTLKAGDRISEKQALSAVMIPSANNIARLLARWDAGSEAAFVKKMNDTAKELGMTST
                     TYTDPSGLKETTVSTAEDQVKLGRMVVKNPALVAITSAASWTDPTGHNWPNWNKLPFQM
                     GAIGIKTGSTTAAGGNLLFASRKTVGGQTVTIVGAILGQHKGPSILDTVNAVSKTALLA
                     AQDALTSSTILKKGDVVGYVDDQLGGHTPVVITKDVTAVGWAGLKVKLSFAPGGVPHTA
                     KAGTKVGTLTVGDGSAAAVKVPVALQKDLAEPGFGAKLTRLG"
     misc_feature    complement(22470..22485)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
ORIGIN
        1 cgggagagcc ggctgatgcc gaccagtcgg tatggacagc ggggttccgg cccggtacag
       61 atgggacatg cgtatcgccg tcaccatctt cctcaccgac gagaccatcg cgccggtccg
      121 gctcgcccgc gaactggagc agcgcggcta cgccggcctc tacctgcccg aacacaccca
      181 catccccgtc gagcggacca ccccgtaccc ggccggcggt gagctgccgc gcgagtacgg
      241 ccgcaccctc gacccgttcg tcgccctggg ccaggccgtg gccgtcaccg agcggctcgg
      301 cctcggcacc ggcatcacgc tggtggccca gcacgacccc atcgccctcg ccaagcagat
      361 cgccaccctg gaccatctgt ccggcggccg cttcacgctc ggcctcggct acggctggaa
      421 cgtggaggag gccgccgacc acggcgtcac ctggcgcacc cgccgggaac tggtccggga
      481 ccgggtgcgg ctgatgcagg ccctgtggtc cggggaaccg acgccctacg acggtgagtt
      541 cggcggggtc cgggccagcg acgcgtaccc caagccggcg cagaagccgc gcggcccggt
      601 caccggtccg cgcacgctgg tcggcggagc ggccgggccg aagctgttcg cgcacatcgc
      661 cgagtacgcc gacggctggc tgcccatcgg cggccgcggc ctcaccgagt ccctgccggt
      721 actgcgctcg gcctggacgg ccgcgggccg cgacccgtcc gccctccaga tcgtcccgta
      781 cgcggtcctg ccggccccgg gcaaactcgc gcactacgcc gagctgggca tcgaggaggt
      841 ggtgctgcaa ctgccgccgg cgggggaagc cgaggtgctg cgggtgctgg acgaatacgc
      901 gagcttcctg taggcctgat ggagccgtag gccctgatca cgccgaacgt atggttgagg
      961 gatgacgact tccgcgacct ccggaaccgg cccgaccgag aactccatgc gtcgcgccct
     1021 caaacgtgcc cgggacggcg tcgccctcga cgtcgccgag gcggcggtgc tgctccaggc
     1081 tcgcggcgag gccctggccg acctcgccgc gtccgccgcc cgggtgcgcg acgcgggcct
     1141 cgaacaggcg ggccggcccg gtgtcatcac gtactcgaag agcgtcttca tccccctcac
     1201 ccggctgtgc cgggacaagt gccactactg caccttcgtc accgtccccg gcaagctgcg
     1261 ccgggccggg cacgggatgt tcatgtcccc ggacgaggtg ctggacatcg cccgcaaggg
     1321 cgccgccctc ggctgcaagg aagccctgat caccctcggg gacaagccgg aggaccgctg
     1381 gcccgaggcg cgcgagtggc tcgacgcgca cggctacgac gacaccatcg cctatgtccg
     1441 cgccgtctcc atccgcatcc tggaggagac gggcctgctg ccccacctca acccgggcgt
     1501 gatgacctgg acggacttcc agcgactcaa gcccgtggcc ccgtccatgg gcatgatgct
     1561 ggagaccacg gccacccgcc tctggtccga acccggcggc ccccactacg gctccccgga
     1621 caaggaaccg gccgtacgcc tgcgggtgct ggaggacgcc ggccgctcct cggtgccctt
     1681 cacctccggc ctcctcatcg gcatcggcga gacctacgag gagcgggccg agtcgctctt
     1741 cgcgctccgc aaggtctccc gggcgtacca cggcatccag gaactgatca tccagaactt
     1801 ccgcgccaag ccggacacgg cgatgcgcgg catgccggac gccgaactgg acgagctggt
     1861 cgccacggtg gctgtggccc ggcacatcat ggggccgtcc gcctgcctcc aggccccgcc
     1921 gaacctggtc gactccgagt acgagcggct gatcggcgcc ggtatcgacg actggggcgg
     1981 ggtgtcgccc ctgaccatcg accacgtcaa tcccgaacgc ccctggccgc agatcgagga
     2041 actcaccgaa cgctcccggg cggccggctt cgaactgcgt gaacgcctct gcgtctaccc
     2101 ggagttcgtg cgccgcggcg agccctggct ggacccacgg ctgcgcccgc acgtcgccgc
     2161 gctcgccgac ccggagacgg ggctcgcgcg cgaggacgcg gtggtcgaag gccacccgtg
     2221 gcaggagccg gaggaggcct tcgtacccac cggccgcacg gacctgcacc gcaccatcga
     2281 caccgagggc cgtacgaccg accggcgtga cgacttcgac gaggtgtacg gcgactggga
     2341 ggcgctgcgc gaggcggccg cccccggcat ggccccggag cgcatcgaca cggacgtccg
     2401 ccaggcgctg cgcaccgccg ccgacgaccc gacgcggctg accgacgccg aggccctcgc
     2461 cctgctgcac gcggacggac cggcgctgga cgcgctgtgc cgggtggccg acgacgtacg
     2521 caagtcggcg gtgggcgacg acgtcaccta catcgtcacc cgcaacatca acttcaccaa
     2581 cgtctgttac acgggctgcc gcttctgcgc cttcgcccag cgcagaaccg acgcggacgc
     2641 gtacaccctc tccctggagc aggtcgccga ccgcgcccag caggcctggg aggtgggcgc
     2701 ggtcgaggtg tgcatgcagg gcggcatcca ccccgacctg ccggggacgg cgtacttcga
     2761 catcgcgaag gcggtgaagg accgggtccc gggcatgcat gtgcacgcct tctcgccgat
     2821 ggaggtcgtc aacggcgcga ccaggacggg gatgccgatc cgcgagtggc tgtccgccgc
     2881 caaggaggcc ggcctggact ccatcccggg gacggcggcg gagatcctcg acgacgaggt
     2941 ccgctgggtg ctgaccaagg gcaagctgcc gacggccacc tggatcgagg tgatcacgac
     3001 ggcccacgag gtgggcatcc gctcgtcctc gacgatgatg tacggccatg tcgaccagcc
     3061 ccgccactgg ctcggccatc tgcgcacgct ggcccggatc cagcgcgaga cgggcggctt
     3121 caccgagttc gtgacgctgc cgttcatcca cacgaacgcg ccggtctatc tggcgggcat
     3181 ctcccgcccg ggcccgacga cacgggacaa ccgtgcggtg acggccatgt cccgtctcct
     3241 cctgcacccc tggatcccca atatccagac aagctgggtc aaactgggtg cggaaggtgc
     3301 ggcggagatg ctccgttccg gtgcgaacga cctgggcggg acgctgatgg aggagacgat
     3361 ctcccgcatg gcgggttcct cctacggctc gtacaagtcg atccgcgacc tggtggccgt
     3421 ggccgaggcg gccggccgtc cggcgaagcc gcgcaccacg ctctacggcg aggtctccgc
     3481 cgagcggcag cgggcggccg gggcctccga cgggcacctg ccggaattgt tgccggtcct
     3541 cgactgagta cgatgatccg accccggacc gagaaggggc cccagagcgc cccctagcgg
     3601 aggagatgcg tacccgtggc tgcccgactg ccctcgtggg cctgggtcac cggtctgacc
     3661 gtgggagcga ccgcggccgt cgtcgccctc gccgtccagg cggaccacgg gccgcatccc
     3721 acggccgccg tggcgagccc cagcgcttcg gcgtccgcgg gcgcccacgc gtccacgcgc
     3781 ccgaagcccc cggccccgcc cgtgctgccg gccgcgtcgg gcgtgggccg ccggatcgtc
     3841 tactcgatcg gcgggaagcg ggtgtggctg gtcgacgcga cgggcaaggc gacgcgtacg
     3901 ttcacggtgt ggccgggcac ggtgaacccg cagcccggcc ggtactcgat catcaagcgc
     3961 atccagtccc tcaagggctc ggacggcgtg gagatcgagc acgtcatgta cttcaccgtc
     4021 gcgtccggcg tgaacatagc cttctccaac gcactggacg gctcctcgcc gccgccggcg
     4081 gacggcaaga agctgggcgg catccgtatg gacaaggagg acggcgccgc cctgtggtcc
     4141 ttcggtgatc agggcaccgg cgtggcggtc gtcaactagc gtcctgccgg acctctcccc
     4201 ggcgggaggg aagctggttg acgatcaggg cgaccccgct gagggtgaag atccgggtcg
     4261 ccgcttccag cccgttccag gtcttggact gccacatcga gaaccactca ccgccgatcc
     4321 cgatgaaccc ggcaccgaag agcagcaaca gcatcagcag gccgtaggtg gagatgcggc
     4381 gggcgaggtc gtctttgcgc catgcccaca gccaggtccc ccagatcagc acgagggcgg
     4441 acgcggtttc ccacacgatg atgaggacat acgcggtgtc ctgaagaccg gtgctggaga
     4501 cggcccgcca catcaggtcg tggtccttga acgtcgtgtc catcgccagc acatgccgta
     4561 cgaactgctg gttcgtcccg aagtcggtga tgttcccgaa ggcgacgagg gcgatgtaga
     4621 gggcgagtat gccggtgagc acaccggcgg ctggcctgag gccggagtga cgtgtggggg
     4681 tggtggtcat ggctgaattc tccctcatcg caagccaggt cagcgcgtgg ccattgcgcc
     4741 agaatgagaa cgcgggctgc gggaggggcg tacggatggc gcaggcacgg ccgtcgatgc
     4801 aggagctgat cgggcggcga aggcggtctg gtttcgtcgg ccgcagcgat gaacgagctg
     4861 cgttccgcga aaacctcgac ctccctcctg aggacgaacg ccaccgcttc ctcttccaca
     4921 tccacgggaa tgcgggcgtc ggaaagacct tcctggtacg ggagttggag cagatcgcgc
     4981 gggagcgcgg ggcgctgacg gtgtacgtgg acgagggcgt ggggagcgtg ccggaggcaa
     5041 tggcggtcgt cagccgcgaa tgcgcccggc agggaaccga gttcaagaaa ttcgaccgcg
     5101 cgctggcctc gtaccgggag cgccgccacg aggccgaggc ggtggccgcc gggctggact
     5161 cggcacagga cggtccctcg ccggtgacgg ccacggtggc gagggccgga ctggcgggcc
     5221 tgggactgat acccggcgcg ggcccgttcg tgggcgcggt cgacgcggcc caactcgccc
     5281 agtacgccga ccgattgcgg cgcgggctca gcgcgaggtt cagcagccag gacgacgtac
     5341 agctggtgct gtcgcccgag cgggcactga cgcccaggct gctggacgag ctgacggacg
     5401 tggcgtccgc cgtgccgtgg atcatcctgt tcttcgacac gtacgagcgg accggaccgt
     5461 tcctcgacgg ctggctgcac gggatgatga ccaccgacga ctacggcgcc ctgcccgcca
     5521 acgtggtcgt ggtcacggcg ggccagcacc ctttcgacag agcccgctgg ggcggcttcg
     5581 cggacttcat gacggagata ccgctcgggc cgttcacaga agcggaggcg cgggggctgc
     5641 tgaccgaacg gggagtggtg gccgagccgg tcgtgacgga ggtcctgcgg ctcaccgggg
     5701 gactgccgct gctggtgtcg acactggccg agcagcaacc cgccgacctg gaggacatcg
     5761 gcgaccccag cgcgacggcg gtggagcggt tcctgaagtg ggagcaggat ccggtgcgcc
     5821 gggcggtggc actcgcgtgt gcgctgcccc gggggctgga catggacgtg ttccgggcgg
     5881 ccgtggacag cccggacgag gaagcggaca gcctcttcgc ctggctgcgg gggctgccgt
     5941 tcgtggacga ccgaggtgac cggctgcgct accacgacct ggtgcgggag acgatgctgc
     6001 ggctgctgcg ccgaaggtct ccacaggggt ggaaggaacg ccacgagagg ctcgcaacgg
     6061 tctacggccg ctggtgcgag gaggccgccg acggcatccg ccctgcctac acgtgggagc
     6121 acgagcgatg gcgcgagctg cggctggagc aggcgtatca cctcgtgtgc gcccgtccgc
     6181 gtacggaggt ggctcagacg ttgatgagtg ttgtcgaggc ctgttggtgg gaccaggtgg
     6241 acggccgccg ctgggcgcgc atgctggagg aggcgggcac cgtggcggac gacgcggatc
     6301 tgcgggactg gggccggcgg ctccgggacg cgctcgccga cgaccagcac ggggtgagcc
     6361 ggaccgtgga cctgctcctg tctcgccccg ggctcgatgt ctccgggcga gcgctggccc
     6421 acgggttgcg gggaaggcag ctgaggagag gcggtgagca ccggcgggca ctggccgagt
     6481 acgacagggc agtcgcactc agcgagcgcg cttccctccc cgagatgcac ctggcctcac
     6541 tgtatttcgg tcgtggcgtc acctgccaga tgctggatga cttcccggca gcgatggccg
     6601 acctggaccg ggcggatgcc ctgtgtcccg acgacgcgga gatcctctac gggcgtgggg
     6661 agacccatcg gctggccggc cggctggagg aggccgtcac cgagttcgac cgcgcccttg
     6721 ccgtggaccc ggccgacccc gactcgctct cgtccagagc agcttgtctg catgcgcttg
     6781 gccgcctgga tgaggcgctc gccgacttcg accgtgcgct cggtctcgcg caggggttcc
     6841 tgtgggcact ggtccgcagg gcacggctgc gtcgtgaccg tggggagtgg gaggaggcgt
     6901 tcgcggatct cgacagggct gtaaccctcg cgccggagtc ggcctgggtg gcgtccgagc
     6961 gaggcgacgc ctaccggctg gcgggccggt tcgaggaggc ggtcactgag ctgggtcgcg
     7021 ccctcgaact caaactggac tacgcctcgg ccctggcagg ccgtggtgtg gccctccgtg
     7081 agctgggccg gatcgaggag gcactggccg acttcgaccg cgcggtcgaa ttgatacccg
     7141 agtacgcctg ggcgctgggg caccgcgcca tctgcaagca acaactccag gacagtgaag
     7201 gcgagttgac cgacctgcgc cgggccgtcg cggcggatcc ggatctcggc tggatccaca
     7261 ccgcgctggg cgatgcgcat tggcgcgccg accagtaccg ggaagcactg ccctttctcc
     7321 agcgggcact ggaactgggt cccgacgacg cctgggccct ggccctcctc ggcgccgcgt
     7381 accgcggtct ggggaactac ccggaagcct tccggtgcct ggaccgggcg gtggccctgg
     7441 actccgggta cggctgggcg ctgagccagc gcgcgatggc cgccatggcg gtcggccgca
     7501 cggagcgggc cctggccgac ctggaccggt gcatcgccct ggagacgcgc gtggactggg
     7561 cccgggagca ggccgtggac ctgctgatgc ggtgcggtcg atggccggag gccatggaac
     7621 ggctggccga ggcggaccgc ttggggcttc ccgaggaagc cctggaggcg cagcgcgcgg
     7681 aagcgtaccg gcacgctcgc cagtgggcgg cggccagacg gcaggccgag cggatacgag
     7741 tgcggagtcc ggccgcgggc atcttcgaac tcgccctgac cgtcggcgga tccgatggtg
     7801 ccagtgcggc gcggtcacta tggcgggagg ccgaacgatg gctgcagtcg gtcgacctgg
     7861 aggcttcgga ccgcgccctc acccggtgcc tcgtgagctg tgccctgggt gactggcgca
     7921 tcgccgacgc gacgctcacc cacctgctgg ccgaggaaca ggactgggac gacctggcgt
     7981 tgcttgcatc cgtactcacc gagctgatgg ccgccccagg agcggaccga gcccgcatgg
     8041 cgccccggct ggcggcggtg gaggcggccc gggacgccgt ccaggcgcgc tatgcggagt
     8101 gagcggcgaa gccgacgaac tctgcaacgt cacgtggtac ggctgaaaca ggccgcagct
     8161 tgccgggctc accgtcctcc tgcaggtggt gggcgtagct cgcccgggcg gagcatctgg
     8221 cttgccgcca gttcgcggta gagggcactg ccggtgagca gctcctcgtg gcgcccgacg
     8281 gccgcggtgc ggccgtcctg cagcaccacg atgtggtccg cgtgctgcac ggtggacaga
     8341 cgatgggcga tgacgagcag ggcgcactcc tgggcgacgt ccttcatgac ggtggtgagc
     8401 gccgcctcgt tgatcgcgtc gaggtgcgag gtgggttcgt ccagcaggag cagtgcgggg
     8461 cgggccagca acgcgcgggc gagggcgacg cgttggcgtt cgccgccgga gagcgtgctg
     8521 ccgcgttcgc cgatgacggc ggccaggccg ccgggcagcc ggtcgacgac ctcttccagc
     8581 cggaccagtt cgacgacgcg ccggatctcc gcttctgggg cgtcgggcac ggcgtaggtg
     8641 atgttgtcgc gcagggtgcc gtggacgaca tgggtgttct gatcgacgac ggcgatgccc
     8701 cgtcggcatg cgtcacgggt gagttcggcc gcgggccgtc cgtcgaagag cacggtgccc
     8761 gcgtcgggct cgtagaacct cgcgaccagg gcgaacacgg tgctcttgcc ggctccggac
     8821 cggcccacca gggccacgtg ccggcgctgc gggacggtga acgagacgcc gcggaggacc
     8881 ggccgccgcg ggtcgtagcc gaagtggacg tcgtgcaggg cgagggcggg ccgttcgcgg
     8941 gtggcgggcg gtcgcggcgc gggggcgtgg tccgccggga tctgggctgt ggtgggctcc
     9001 accggcaggc ggagtgcctc ctcgacgcgc tggtaggcgc ccatcccgcg ctggacgagg
     9061 cccaccgcac ggaagacgga ggacagcggc agcacgaggt acgaggcgta cagcaggaag
     9121 gcgacgaggt cgccgaggga tccggcgtgg ccgctcaccc gcaggccgcc gacgaccagg
     9181 acgatcagga aggagccctg gacggcgagt tcgacggcgg agctcatgac ggcggcgagc
     9241 ttcgcggcac gtacgcccga accgtaggcc gcgtcgacac gggcgccgat gccggccgcc
     9301 tcgcgctgct cggcgcggtg cacacggacc atcggcagcg ctccgagggc ccgttccaga
     9361 tcggcggcga cggcaccgac cgcggcctgc atgtgcgcgg acgcgcccct gatacccgtg
     9421 agcagcgagg cgacgaccac ggctgccgct gccacggtga cggccaccag gagcagcagc
     9481 agggggtcga gccacgccat gagaatgatc gccccggcgg agaccatgct gcctgtcacc
     9541 agatcgacca gggcctggga cacgacctcc cggagcacgg tggtgtcggc cgtcacccgg
     9601 gagatgaggt cgccgccccg gtggcggtcg tactccctca tctccagccg gagcagccgt
     9661 cccaccagcc cgtgacggag ctgccgtacg acgccttcgc ccatccgttc cagcaggaag
     9721 cgtcccgcgg ctcccgccgc cgcctcgacg acgaagagcg cccccaggag tcccagcagt
     9781 ggccagatca cctgtccgcg gccgctcgcg tccacgacgt ccttggcgac gagcggctgg
     9841 gccaggccca gggcggagcc cacgagggtc agtacggtgg cgacggcgat ggcgccgcgg
     9901 tgcccggcgg tgagccggta catcgtgtcc accgccgcca gggtcgaccc gtcaccctcg
     9961 gcggcatcgg cccgttcggc gtgcggggcc gtcgggccgg tcatcggtcc gtcgcccggg
    10021 gcagcgggcc gaccgccacc agccgggcga agtagccctc cggcgcaccc tcgccgacgg
    10081 gaccgccctc cgcctcgatc caggcgtgcg cggtgaaggg cgggacgatg cgtaccccgg
    10141 tgcaccaggt cggccaggtt ccgccgagcc ggcacagcag tgcggccccc agggagcgcg
    10201 gcaggcaccc cttcggtccg gcgcagcgca gactggcggc gcacatggcg tcgcgcgcgt
    10261 tccgggcctc cgcggcggtg gcgggtctgg cgccgcgccg caggatgccg agtacggcgc
    10321 ggatacggcg gggcggcagc agggcgatgg cgagggcggg gagcaggacg aggcgggcgg
    10381 ccaggcggcg gggcagaggc acaccggtcg gccgctccag cgcgctgggc gttgtcatga
    10441 ggcgagcccc gagtcgcgca gctgccgtac gagtgcctcg acgtcccgca gggcctgcgc
    10501 ctcgtcgatg tcgaactcct ggaccagggc ggcggccgcg tccgcctcct cgccgccttc
    10561 gaacagggtc cgcaccacca gggtggctgt cggattcaac tcccagtagg cgccgccccg
    10621 ttcgtccagc agtacggtgc cgtagtcggt ctgggccgtg gagacgttgt cgccgaaccg
    10681 cagaggcatg tgagggcctt tctgatgtgg ggatgcggtc aggggtgtgc ggcacgggtg
    10741 cggctgcggt ccagtccccg cagccacacc tcggcggcga tcgtggagta caggatggcg
    10801 tcggacagcc ccttggaggc gggccgctgg gcgaggcggc gcagctcggc gccgtccacc
    10861 aggcccagct ccgccagccg tgagtcctcc cacagggcca gcaggtcggc tcggtggtcg
    10921 cgcagtccgt tggcggcgtc catggcggcc gtcgccttgt tggcccgccg cagacagtcc
    10981 tcgggcacga ccccgcgcat cgcggcggtc aggacgggct tgtacctcca gggtgtgacg
    11041 cgctcgctcg gacgaacggc gagacacgcc tcgatgaccc ggtcgtcgag gaagggcgag
    11101 gccatcggca ggcccgcgag cgccgccatc cggtcccact gccggatgat gcgggtgcac
    11161 gagcggatct gctccaggtc ggtgtggagg ccgcggtccg gatgcagcgg cgcggccgtc
    11221 gccgctgcgg cgagcagcgc ccggcgggcc atccgctcgg tctcgggagt cacccagtcg
    11281 aacaggcgcg gggtcatgcc ccagccgaga ctcgtcgtga cggacggggg caacgggcca
    11341 cgcagccggc cggcggcgtc ggcgagccac ttcccgtacg gccgggagtc ggcgagagcc
    11401 cgggccgtgc cgccgagcgg ccagtgccac agcgcccggt acccgcgcaa ctggcgcagg
    11461 gcgaacagcg gacgggtgcg cagcagccgg tggtagtacg cgtcggagca ccacgccacg
    11521 tggtcgccgc cgatgccggt caggtgcagc cggctgccgc gtgcggtgag gccgggcagg
    11581 tggtgcagga cccgggagcg gtccatgacg ccgatggtgg gttcgtcgag gaggtcgtcg
    11641 atgccgagca ggtcctcgta gaccagcggc gaggcgtcgg cgtcccagac cacgtgctcg
    11701 acgtccggga ggtgccccat ggctcgctcg gcccagtgca ggtcggtgtc cgccggatcg
    11761 cgtcccggcc aggtactggc caccacgtgg gcgggggagc ggtcggccag gaaacagacg
    11821 gaggtcgagt ccaggccgcc ggacaggtcg cagctcacca cgccgccctg ccgggtacgc
    11881 gcgccgacgg cctcctccag cgccgtccgg atctggggcg ccgcctcggc gagcggccgc
    11941 acgggctccg gcggcgtcca ccaccgggtg tgccgtacgg tgcggccgtc cgcggcgacg
    12001 accacggcgt cctgcggggc gacggcggtg acggaccgcc acatcgacgt ctcgaacagc
    12061 ggatacggag cgggccacag cagtcgtacg gccagttcct cgatgtcggg gtcgaggccc
    12121 agggcggcgg cgagcgtgtc ggcgcgggtg gcggccactt gcactccgtc gatctccgcg
    12181 tggaagacga ggcgcagtcc ggaggcggtg ccctgcaccc tgatccgtcc gtcgagggcg
    12241 ccgacgaggt ggaaactgcc ggggagggat cgggccaggg cgtcgagctc cgcgagatca
    12301 cgcagccgcg cggtacggcg tcgtagttcg tcggcgtcgg ccgggcagca gccgacgacg
    12361 gcgacgcagg cgccgccggc gcctgccgtg acgacctcgt cgtcgtgcca gtggccgacc
    12421 agccagggcc ggcccgacgc gtgcgcgagg gtccggctac cggggcgggc gaaggagcgg
    12481 gccacggcgg ccgcgtccgc acggtccggg aagaccgcga agtgcgcgtc gccggggccc
    12541 gtccccgcac ttgcgtgcag ttcagtcatg gcgtcaggtc aaggaccgtc ggtcgtcagt
    12601 tcttgctgaa gatcagccgg tcgtttccgg agcgctgaag cagccccgtc tccttgcgga
    12661 acgtaccgag ccggacgagc gtcggcgcct cataagcctt cttcatgact actcctccca
    12721 tgcgggtttc cgaccactcc ccctgagcgc gggcccgggc tcgtcgggag ccggggccag
    12781 gaagcggccg cagcacatag ctagctgcag agcgtgaggc gaaggcaaga gcctcggtga
    12841 aggtcggata ataggcacaa tccgtacgcc tcgggttgtg cgccccgctc gttctggctg
    12901 tcgtcagcgc ggcgttggca tgcggcctcg gtatgcgcat cctcaaataa acgttttgag
    12961 atgccgtccg gcagttgttg acggcatctg ccggaggcac ctgacggcag tcgcggacag
    13021 gcgccgccgg gcgcactcca ggccggggct cacctcttgg cggccgggac gaggcccggg
    13081 gcgaactggt aggagatcga ctccagcagc ggcttgcggg tcgccgggaa tgaccggcaa
    13141 cgggtgattt ggccccgtga acgcgccgtt cgctgtcgat tacagtgctg gatgtcgtac
    13201 ggacggacgg tgccgtgagg aggtctgcgt gggtgcgaca tccggcgccg tctggggccg
    13261 tgccgaacaa caggacttcc gcagcagggt gcgcggcacc ctgctcgggg ccgccgtggg
    13321 cgatgcgctc ggcgggcccg ccgacccgct ctccctggag gagatccggg cgacgtacgg
    13381 ccccgagggg ctgctcgacc tggccttcgg gcacggccgg cgcggcacgg tcacccacca
    13441 cacccagctc accctcttca cgctggacgg gctgatacgc gcccaggtgc gccgcgacac
    13501 cggcgcctgg catccgccga ccgatctgca ccgggcgtac cggcgctggg cggccaccca
    13561 gcgggactgg gggcccgacg agcgccgcaa ggacgacggc tggctcgccc gcgaagagtg
    13621 gctctacgcc cgccgcgagc cgacccgggc cctgctcgtc ggcttcggag acgacacgct
    13681 cggcaccctg gagtcaccga agaaccccgg cgagctgggc ccggaggccg tggcccgctc
    13741 cgcgccgttc gggctgctgg tcggctggga gccgcagctc gtcgcacagc tggcggtgga
    13801 gtgtgcgacg cagagccatg ggcacccgat cgcctacctc tcggcgggcg cgtacgccgt
    13861 gatcgtgcac gcgctggccc ggggcgagag cctggacggc gccgtgcagc gggccctcgc
    13921 cctgctcgcc gcccgccccg gccaccagcc cgtctcggac gccctgcagc atgccctcgg
    13981 cgcggtgcgg cagggaatac ccagcccgac ccgggtggag gagctggccg gggacggtac
    14041 ggcggacggg ttgctggcgg cgtccgtgta ctgcgcgctg gtgggggagg acgtacggca
    14101 cgggctgtgc ctggcggtga accagggcgg gccgtcggcg gcggcgggcg cgttgacagg
    14161 cgggctgctc ggcgcgctcc acggcgagac ggccctcccg ccagggtggc tgacagagct
    14221 ggagggccgg gcgacgatgc tggaactcgc ggatgatttc gccatggaga tgactcaggg
    14281 tcccgcgttg cacggtcctg cggggtccgc accgggctgg ctggcgcggt acccgcgggc
    14341 ctgagggagc gaacggccac gacggacccg cagccggcaa cggatccgca cccctacggc
    14401 gctcccacca cgtcccccgc cgggaccgcc accccatccc cgtccgtatt gaccttctcg
    14461 atgatcgcca gcctctccgg cgtatcctcc ggcttcacat agccgatgac gatgtacagg
    14521 gccagggaca ccgccagcgg caccgagacc tggtactgca gggccactcc gccggagacg
    14581 ttccagctga cggggtagtt caccagccag aacgccagca accccgccgc ccagctggtc
    14641 agcgccgccg tgggaccgga gcggcggaac ggccggagca gacccagcat catcgggatc
    14701 gcgatcggac ccatcagacc ggccacccac ttgatgacga cggtgatgat gtccttgaac
    14761 gtgggcgagt tgacctgggt ggcgacagcc atcgacaggc ccaggaagag gaccgtcgtc
    14821 acgcgcgccg cgatcagacc cgagcgcgca ctccaggccc gcgcgcgagc ggacagcacc
    14881 ggcgccacgt cccgcgtgaa caccgccgag atcgcgttcg cgtcggagga gcacatggcc
    14941 atcgtgtggg agaagaagcc gacgatcacc aggcccaaca gcccgtgcgg cagcagctgt
    15001 tcggtcatca ggccgtagga gtcggagccg tccggcttct gcgcgtggac caggagcggg
    15061 gacatccaca tcgggaagaa caacaccacc ggccagacca gccacaggat cgctgacagc
    15121 cgggcggagc gctcggcctc gtgcgcgctg cccgtcgcca tgtaccgctg cgcctggttg
    15181 agcatgccgc cgttgtattc gaagagcttg atgaacagaa acgcgaagag gaagacagtg
    15241 ccgtaagggc ccaccagcgg tttgccgtgg ccgtgcaggg ccggctggct ccaggcgtcg
    15301 aagaagccga tgtgcttgtc gttcagtttc agtacgactg cgacgaacat cgagacaccg
    15361 gcgagcaact ggatgacgaa ctggccgagt tcggtcagcg cgtccgccca caggccgccg
    15421 atcgtgcagt acacggcggt gatcgcgccg gtgatgagga tgccctggtt caacgacaca
    15481 cccgtgaaca ccgacaacag ggtggcgatg gcggcccact tggcgcccac gtccacgatc
    15541 ttcagcagca tgccggacca ggcgagtgcc tgctgggtgg acaggttgta acggttcttc
    15601 aggtactcca gcggggaggc cacatggagt cgggaacgga gtcggttgat ccggggcgcg
    15661 aacagcctcg acccgatggc gatgccgagc gcgatgggaa aggaccaggt cacaaatgaa
    15721 gtaacgccat acgtataggc gatgcccgcg taccccgtga acatcaccgc gctgtagccc
    15781 gacatgtggt gcgagatgcc ggacagccac cagggcatct tgccgccggc cgtgaagaag
    15841 tcggagacgt tgtccacgcg tttgtgcgac cagacgccga tcgccaccat cacaccgaag
    15901 tagccgatga gtacggccca gtcgagactg ttcatgtgct cgatcgtggg tgcggtcacg
    15961 tgaacgcgac aagcgagggt agggtcaagt caaagcaaag atgttcgctt tgatgattta
    16021 tgttcacgca cctgaacgca gctgaacgta tggacggcgg cgcggggcgg ggtcaccgca
    16081 tcagttcccc cgcgttgacc agcagcgact gccccgtgat ggcccgcgcc cgatccgagg
    16141 acaggaacac caccgcgtcc gccacgtccc cgtccgtcgc cagctccggc agcgccatcc
    16201 gctccgtcag ccgccccagc acctccgcct ccggcacccc ttccgtctgt gcggtgaact
    16261 gcacgtacgc ctgcaccggc ggcccccaca tccagcccgg cagcacggtg ttgacccgga
    16321 tccggtgtgg cccgagttcc cgggccagcg agtacatcgc gctggtcagc gcccccttcg
    16381 acgcggcgta cgcggcctgc ttcacctgtg agggtgccgc gacggccgac tgtgtcccga
    16441 tgaagaccac gcagccgccc ccgcccgcct tcagtgacgg caggcacgcc cgggtcatcc
    16501 gcagggtgcc cagcaggttc acgtcgatga ccgactgcca ggtcgcgaag tccgcgtcct
    16561 gaagcccgcc gaagtgggag tcccaggccg cgacatggac caccgcgtcg atgccgccga
    16621 accgctcccg cgccagctcc gccagcgccg cgcactgccc ctcgtcggtg atgtccgtcg
    16681 cccggtacgc cgtacacgtg ccgtccgggt cgatctcggc cgcgctcttg gcgaggttcg
    16741 cctcggtgcg tgccccgagc accgcgttcc cgccgtcccg tacgacggcc gcggcgacct
    16801 gatggccgag cccggccccg actcccgaga cgaccacggt cttgccggtg agcagtggca
    16861 tgaggacccc tcccggaccc tggcgcttta tctgacggag cgtcagagta tgggcgaccg
    16921 caggaggacg gaaggggacg gaaggggaaa cccatgagcg aggacatgag tgaggacacc
    16981 cgcagcgaga cgtacggcga actggccgcc gtgggcccgt acggcgtccg cccgggccac
    17041 gccctgatca ccatggtcga gccgcacccc ggccacgagc acgcctacaa ccgctggtac
    17101 gaggacgacc actactacgc cggcgcgatg gccatgccct ggatgtacgc gggccgccgc
    17161 tgggtggcga cccgggatct gcagctcctg cggtctcccg agaagtcggc cgtcgcccag
    17221 ccggtcacgg ccggctgcta cctctccacc tactggatca ccgacggccg ctacgaccac
    17281 cacatgaagt ggaccgtcgc catcaacaag cgcctcaacc gcgacgcccg tgtctaccac
    17341 gaccgtaccc acgtcttcac gtccttccag gaccacgaga cgaccgtgta ccgggacggc
    17401 gcggcgggcc ccagggactt ccacgccctc gaccacccgt acgccgggct ggtgctggag
    17461 gtgatcgaca gcgagtcggc cgggcagcgg gcggagctgc tgcggtggct gcgcggccgg
    17521 cacctgccca agcgcctggc cggctccccg gccgcgctgg tgaccgtgtt ccggcccact
    17581 ccgctgcccg gcgaccgcat gtcctatgtc aagcaggtcg agggcacgga cacccggctg
    17641 accctgctgt ggttcctgga gcgggaccca cgggagtgct gggaggagca cttcaccggg
    17701 ctcgatgcgg acgtctcgga ctccgggctg ggcagggtgg agctggtggc gccgttcatc
    17761 ccgacgattc cgggcaccga cacctatgtg gaccggctcc gctgaggctc agggcttcga
    17821 ctgaggctca gggcctcagc gcgtcttgaa cacgtccggg cagggtgtgc cccggggaag
    17881 ctggtacggg gccgccagcc ggtaggtgcc cggcttcggc gccaccagca tcgtccactt
    17941 gtcgcccttg gcgtcctgag gcgtctccat cagacacccg ttggtgttga cgtatgtctt
    18001 cgccgtcgtc tgctgcggag ccttcaggct cttgccgtgc tcgtcgacga tgctcagcca
    18061 cggcgagtac gggatcctga tcaggatccg cccggccttg cgcacctgaa gcgtcatctc
    18121 gccctgcccg gcgtgatcca ccaccgcgtc gggctcggcg agcggcgtcg catcggtgac
    18181 ctggaacagc tgccagttgg cgtcgcccca gacctgcttc agatacggca tcccgcgccg
    18241 cagcagctgc cgctcgcgct cgccgccgtc gccgtccggg ttgtccttcg gcaggacgac
    18301 gaagtggacg gcccagcgct ggagccactc gtggtagttc gccgagttga gggtgtcgtc
    18361 gtagaagagc gggttgcgct ccatgtcggc ctgccggttc cagccgcgcg ccaggttgac
    18421 gtacggcgcg agcgcggacg cctcccggtg cgagcgcgcc gggacgacct cgacccggcc
    18481 cttctcggca ccggccttct gcagctggtg gacgagcggg gcgagttcac gggcccagga
    18541 cgcggccggg gtcgtgtgca cgatgtcgtc caccgacttg aagccgatcc agccggcgaa
    18601 gccgagcagc gccagcacgg tcacgtacca cctgcgcgac ttccgcaccg tgaacggcag
    18661 cgcggccacc agcgtcgcac ccgcgaacag catcggcagc cgggagatgt tcgagccgat
    18721 ctgcgagttg accagccaga ccaggaccac acccaggctg tacacggcgg ccgtcagccg
    18781 gaccgtcacc cactccctgg ggaccaggaa caggcacagc aggccgtagg ccaggggcag
    18841 gatcaccgag ccgatggtca tcggctgggt accggagaac gggaacagga agtacgaggc
    18901 ggcgaccacc accgtcgggg cgagccccag cgcccaggcg ccgggccgcc gtttctgcag
    18961 gaacagcgcg accgcgacca gcccgacgaa cagcccggag accggcgagg ccatggtgga
    19021 cagaccggcc agcggggcgg ccaccgccgc cttggcccag cgtttgtgcc gccagcggta
    19081 cggccagcag aagacggccg cgacggcgcc gagcgcgaac atcgtgccga gcccgaaggt
    19141 cacccggccc gagatcgcgt tgcacaacag cgcgacgacc ccggcgagcg acgcccacag
    19201 cgggttgcgt accgcccggc tgcggatcag gaccagcgtc agcaggcccg ccgagaccgt
    19261 cccggcgatc atcatcgtcg tacggacgcc gaggacggcc atcagatatg gcgacaccac
    19321 gctgtacgac accgggtgca taccgccgta ccaggcgagg ttgtacgccg agtccgggtg
    19381 ccggccgacg aactccgccc aggcgtcctg cgccgcgaga tcgccaccac tattcgcgaa
    19441 cgtgaagaac cagaggatgt gcaggacccc cgcgagggcc gttatggaca gcacggggtg
    19501 ccgcagcagc cgcgggcgca ggggctcggc ggcggtgagc aggcgcgcga gcccgcccgg
    19561 gcgcacaccg gggccgtcgg gcggtccggg acggtcacgg tcggtagggc cgtccggggg
    19621 gccggtgtga tccgtgtgcc cctccgggcc ggcttcggac gcgcgtattc gcgggccgga
    19681 tcccgggccc ggatcggcgt cgtcagcgcg tgtcggctcc gctgtggcca cctgaaggca
    19741 ctccccgtgt cccgtcttct gttctcggtc gtgttccatg gtgttcccgg ccgcttcccg
    19801 tccagttcgc ggccctgtcc cgtgaccggc gacctgcccc gattcgtgac gctagcacgc
    19861 accccgtcac ggggctcccg ggtggagccc ccgccgacgg ggtgcgcggg gcggaccagc
    19921 agtggtgcga tcagcccaga cgggtcagct tggcgccgaa gccgggctcg gccagatcct
    19981 tctgcagggc caccgggacc ttcaccgctg cggccgaacc gtcacccacg gtgagcgtgc
    20041 cgaccttggt gccggccttc gcggtgtgcg gcacgccgcc cggcgcgaag gacagcttga
    20101 ccttcaggcc cgcccagccg accgcggtga cgtccttggt gatcacgacc ggggtgtgac
    20161 cgccgagctg gtcgtccaca tagccgacca catcgccctt cttcaggatc gtggacgagg
    20221 tcagcgcgtc ctgggcggcg agcagggcgg tcttgctgac cgcgttgacc gtgtcgagga
    20281 tcgacggccc cttgtgctgg ccgaggatcg cgccgacgat cgtcacggtc tgcccgccga
    20341 ccgtcttgcg ggaggcgaag agcaggttgc cgccggccgc ggtggtgctg ccggtcttga
    20401 tgccgatcgc gcccatctgg aacggcagct tgttccagtt gggccagttg tggccggtgg
    20461 ggtcggtcca gctggccgcg ctggtgatcg cgaccagagc cgggttcttc acgaccatgc
    20521 ggccgagctt cacctggtcc tcggcggtcg agacggtggt ctccttcagg cccgaggggt
    20581 cggtgtacgt cgtgctggtc atccccagct ccttggcggt gtcgttcatc ttcttgacga
    20641 acgccgcctc cgaacccgcg tcccagcgtg ccaggagccg ggcgatgttg ttggcggagg
    20701 ggatcatgac ggccgacagc gcctgtttct cggagatgcg gtcaccggcc ttgagggtgt
    20761 tgacggtgga ctcgccgctc ttgctgtagc cgccctcctt ctccgcctgg gggtcgaccg
    20821 tgatcttcgg tccctcctgg cccggcttca gcgggtggtc gcggaggacg atgtacgagg
    20881 tcatggtctt ggcgaccgag ccgatggcca cgggggtctg cttgccgaag cggctcatcg
    20941 tgccgatgcc gtcgacgtcc atccagccct gcccctcgcc cggccagggc aggttcgccc
    21001 cggcgccgtc gaaggtgtag ctgtccttgg cggtgagccc gagggcgggg gccggcagcg
    21061 ggcgcaccgc ctgtacgacc gcgaagatga ccgccaggag caggaccagg ggggtccaga
    21121 tcttgacccg gcgcacgatc gtacggaccg cggtctccgg gggcgggggc gtgttcgtca
    21181 gctccgccag gaggtccagc gggggcttcg gagggagggg ctgctgggtg gtgcgctcgg
    21241 ggccgacctg ggggacgggg gtggtgacgt ccggtttggc ggccggcggc ttggtggccg
    21301 gtgccatgtc gttcttgagc gcgacgaact tgctggtgcg ctcggattcg gactccggag
    21361 tcttgggggt gttcgtcctg ccgcccagct tgagcatggt cgtcggctga tcgacctgct
    21421 tgggctttac ggtcttgaag acggcggtgg gctgatcaac agccgccttc gcctgcggcg
    21481 cttcggcgtg gggggcgtcc gcctcggctt cgccgtcggc gtccgtgttc ccacccgcac
    21541 cacccgtgcg gctctcgtcg tcggctgcgg gtggcccctg tggggcgtcc ccgccgttgg
    21601 cgtcctccgg tcggtcctcg ttctccgacc cgcctcgggc cttcggcccg tccttggctt
    21661 cctccgcctc ggccttcggc tctgccccgg agcctgcctc ggccttcgcc tcggcgtcac
    21721 cgtccgaacc ggcctcagca accggggcgg cctcggagcc cgcctcagcc ctcgtcctcg
    21781 cctctgcggc agcgccggcg tctgccgtct cgccgtcgtc gccggccttc ggggccgcgt
    21841 cagccttcgc ccctgccttc acgtcggtgt ccggcttcgc ccccgcagac tctgcctccg
    21901 cgtacccctt cgcgtccgcg tccgcgtccg tcgtctcggg cttcccctcc tcggccgtac
    21961 cgttgcgcgc cccggctgtc tccgcctcgg tctccgtgcc ggcggtggcc gacggagtcg
    22021 tgggcggggt gtttgcaggt gtgtcggagt tgtttgcggg ggcggcggtg cggacccagg
    22081 cggagaccgc ctggcggagg gccgcgtcct ccgccggagt ttccttggtg tccggcttcg
    22141 gcgcgtcagg tatcgagagg atcttcgtcg cggtgtccgc gctcgcctgc gcggaatcct
    22201 tttcccgggc gaccgcgagc cgcggatcgc gcgtctcggg aaccggaccc gcgctccccg
    22261 acgtcggttc cgccgacgac tcgcgctgct tcgacctgtc gggggactcg cccgccaccg
    22321 atgcctcctc catgcgccgc acgcccacgc gcgcgccctg tccgaaccat gtaccagtgt
    22381 cctgtgtgag ggcttggccc ctgcggtaga cgagaacgac atacctaccg gttccctcac
    22441 gaaccggtca cgcaccctcg acagaccgat gtgagagggg tcaccctgtc attcatccac
    22501 gcggggaggc atggatgggc aggagccgca gaacacttcc ggaggagctt ctgctgctgg
    22561 cattggacc
//
