LOCUS       NZ_CM002285            27954 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4194944
            Orig. end                         :: 4222898
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27954
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="triceptide"
                     /product="lanthipeptide-class-i"
                     /region_number="25"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..27954
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="triceptide"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..21378
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21378
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11378](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11378
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            348..1289
                     /locus_tag="M878_RS67865"
                     /pseudo=""
     CDS             348..1289
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004928353.1"
                     /locus_tag="M878_RS67865"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MARIRTIKPEAFVSESLATVSLTAERTFLGLLTQADDQGRHRDHA
                     AIIAGQLWVLRPEHTPSDVETDLAQLADAGLICRYKGPDDKRYLHIVTWHQHQKINRPS
                     KSRLPSCPHHDTPVGTAPGVAAPTARASITEPAPQPHGALRE"
     gene            1286..1984
                     /locus_tag="M878_RS48160"
                     /old_locus_tag="M878_19290"
     CDS             1286..1984
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1151: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004928356.1"
                     /locus_tag="M878_RS48160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19290"
                     /product="ATP-binding protein"
                     /protein_id="WP_031225202.1"
                     /transl_table=11
                     /translation="MTATLTREPHRVGPLADRLNGILASRGIDPGVTGEEPPAEPVTAL
                     ELADARIPARYRRAMADQPQVSAWADEIARAGRPGPGGPGIAEGPSLLIAGPTGTGKTY
                     QAYGAVCGLLSRGVRLRWEATTTADLHARIRPRTGHDAERDLQTLARCPLLLLDDLGAA
                     KTSEWTEELTYRLINHRYEHMLPTLITTNLPTAELRATLGDRVASRLAEMTERVVLTGP
                     DRRRHTAATA"
     gene            2214..3503
                     /locus_tag="M878_RS67870"
                     /old_locus_tag="M878_19295"
     CDS             2214..3503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019982997.1"
                     /locus_tag="M878_RS67870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19295"
                     /product="hypothetical protein"
                     /protein_id="WP_031225203.1"
                     /transl_table=11
                     /translation="MTVVLLVLLVLSALFAGWTIRQQHRRPSATNRWRGTIAVPVAAMA
                     AIGCTTYSADTSWRFAADYLDMGGTTERVAMFAAAELALFATALMARQNLNGPKQAPGT
                     PGTLTWVITAVQILPAYAESGLLGGTVRAFVGPVLAAILWHLAMGIELRHRTPDATSRS
                     LAAILVRQARERLLARLGIADQDADAARLIRERALTEAVALILRAESMTDKKRGKRRRR
                     RLTERLHQALERADVDGDPLQDELLLRKLATRRQALGLASLILPPRWQAPASYTARESG
                     QSRQGSARPASVPRAEQDAARPHPADPGDDEVPPAARLRPARSAPGLPARADTEDSPPL
                     TGNTSGSAPGRRERKPAARKKRNDGKPRASDEVILKYTRRMYEETGSVGRDRVEDALRV
                     DDYTISSDDVGRVVRDFKGQVKAEADAAPR"
     gene            3551..4177
                     /locus_tag="M878_RS67875"
                     /old_locus_tag="M878_19300"
     CDS             3551..4177
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015662421.1"
                     /locus_tag="M878_RS67875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19300"
                     /product="mobilization protein"
                     /protein_id="WP_245238123.1"
                     /transl_table=11
                     /translation="MYSPHHPDPTTHEDSLPITPAPGGASWRSGHSPAGGAPEPDPALG
                     VAGSVRHQGAPDGKAATEDGPQPGKASPKGEARKGKSRPRDKKQRPAHSVRLNEQELAI
                     IQSGADHVDMSVAGFLAHSALAAARDQSRTAAAIATERDILTALFGVRRQLGWAGSNVN
                     QAVKALNSGADALHFAAALADLQRAAQAVQRAADRITNRQEDQAA"
     cand_cluster    3729..27954
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    3729..27954
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[13728:17954](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(13729..17954)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     gene            4174..5910
                     /locus_tag="M878_RS67880"
                     /old_locus_tag="M878_19305"
     CDS             4174..5910
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643942.1"
                     /locus_tag="M878_RS67880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19305"
                     /product="relaxase/mobilization nuclease domain-containing
                     protein"
                     /protein_id="WP_023547799.1"
                     /transl_table=11
                     /translation="MIPRIHEQGSNTLGLLHYLYGKGTHEEHIDPHLVASFDGMAPDPG
                     RDPSVTKKDLQHLLDQPLSLLAADQRPAQHVWHCSVRAAPDDPILSDEQWGDIARRMVA
                     ATGIDPGDGAGCRWAAVRHADDHIHIIATLVREDGRRPDHHRSGKRAQAECRLIEKELG
                     LHQIAPGDGTAAKRATSAERHKAERQGRERPAREELRETVRRAVAGAASEEEFFDRLAA
                     AGLLIRKRVAPSGDLLGYKVALPDDRNKDDEPVFYAGSTLAPDLSLPRIRERWALSAEA
                     AASADGSGPEQPALPAVTGPAFARRRATDATWQALLIIDHGDDGTAAAQIAAAGEILDA
                     LAKTSAAHTRAELRKAAFAFERASRSHIKAVRGHDHALRQAARDLVHSGPALGRGEDGA
                     TTAMLIDMAFFLAIAAANWHARKHHSQQAAAAREAAEHLRAAYEAAAAGSMAILRQRGH
                     RLAPRVRQRQAGLLHQVLPEQAEQVLAEADWPALAATLDDAQRAGHDPAALLTEAAQRR
                     ELDTADSISDVLVWRLRRSAHLPALPESPRDSSARGNRRTPSPAPTTPAATSAVNDSRH
                     QR"
     gene            6016..6402
                     /locus_tag="M878_RS67885"
                     /old_locus_tag="M878_19310"
     CDS             6016..6402
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143639.1"
                     /locus_tag="M878_RS67885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19310"
                     /product="hypothetical protein"
                     /protein_id="WP_023547800.1"
                     /transl_table=11
                     /translation="MPETDIRPRLDIVALLCDADFKYRPDTNTWSHRDGRPFSKEEQAL
                     TFTATRVEFEEVSEQLARYREYRRTWEEASEAFQRFLAPFMEQLTEKNLGNAVQLMSEN
                     DRIEFDRLLGLMIHPLRPFTPNTF"
     misc_feature    6053..6068
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.82"
                     /tool="antismash"
     gene            complement(6682..>6864)
                     /locus_tag="M878_RS98390"
                     /old_locus_tag="M878_19315"
                     /pseudo=""
     CDS             complement(6682..>6864)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005483574.1"
                     /locus_tag="M878_RS98390"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19315"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="APDLGDERWSQLLTYSVRGQRSIVKQTAIRTGKVLVIVSGSPGLV
                     DANLAKALDKTQAAF"
     gene            7108..9873
                     /gene="haaT"
                     /locus_tag="M878_RS67895"
                     /old_locus_tag="M878_19320"
     CDS             7108..9873
                     /codon_start=1
                     /gene="haaT"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017238995.1"
                     /locus_tag="M878_RS67895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19320"
                     /product="cyclophane-containing RiPP biosynthesis TPR
                     protein HaaT"
                     /protein_id="WP_023547802.1"
                     /transl_table=11
                     /translation="MRLRRGIAIAVVAGGGAVTTLLVGLVTNAVSNKSRWPGWLGWLQE
                     HAWFSFVVLGVAMAGLTALLAGLSETRPPSPPGRPEDGAGPGAAQVLRSLPRDTAAFTD
                     RAAELERLVGSVRASQERGEGVPVHVIDGMPGVGKTTFAVHAGHLLSERFPDGQLFVNL
                     NGYTPGRTPVQASEALASLLTAAGVPTQQIPVGDGVGAVTEARAAMWRSRLAGKKALLI
                     LDNAASYRQLEPLLPGGSGCLVLVTSRKRLVANEEVVMSVDALPPDHAVELFVRLSGRP
                     ADALDRDVVDELVRLCGCLPLGVSLLAARLRHHPSWTAEDLRGRLVTAQDRLGELRAGE
                     RAVTATFGLSYRDLAPERQRFFRQLGFFPGTDLDAHVGAALGEVSVVVARLHLEALYDD
                     HLIDEHPGSRYRLHDLLRDYARGLAAEGDSMDHAQAVQRVCTYYLAALAVANEHIVRSG
                     AAVPPAPDGASRVETPVLESRTDALSWLETERATILACVRRANGLALYALVARLAAAMA
                     PFLRQAGPWDQAVALHRTAAEAARHTGDQRARGDALAELGVVRRFMAAYPQAIEALNDA
                     VTAYEAVDDRRGKAEALNQLGIVWYLTADNEDAARAQTEALALYRELGYRLGQANALAD
                     LGMTHRQMSRFDAAVEAQTEALSIYRELGDRYGEANSLRDLGVVHSLMGAYDLAARHHQ
                     EAFDIYLELDDRVHQAYALNELGVVRRLTGDIEAARTAHSQALTHFTELGERFGRANSI
                     RHLGVVERVTGDAAEAIRLLEEALGAYRELGSRGGEAASLSELGVARGIVGERDGAIEA
                     FQRGLEILRGLGDRCGEAEALSHWGMLLLTSDEPTAARRHFGQALTLARDIRCPLEEAR
                     ALEGIGRCDWTVDGPGHGVSSLRAAVTVYRRLGVSAAVDDIERLLVSRSG"
     misc_feature    7234..7236
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..10204
                     /gene="haaA"
                     /locus_tag="M878_RS67900"
                     /old_locus_tag="M878_19325"
     CDS             10001..10204
                     /codon_start=1
                     /gene="haaA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061149.1"
                     /locus_tag="M878_RS67900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19325"
                     /product="HaaA family cyclophane-containing RiPP peptide"
                     /protein_id="WP_023547803.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSPTSVTEPRTITPVGPASAEPTAAGTAVLDRVTARVRQRLEAE
                     EGATGRVGDGAHAASLIWPWPL"
     gene            10218..11378
                     /locus_tag="M878_RS67905"
                     /old_locus_tag="M878_19330"
     CDS             10218..11378
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014061150.1"
                     /locus_tag="M878_RS67905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19330"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_023547804.1"
                     /sec_met_domain="PTHR43273 (E-value: 7.4e-73, bitscore:
                     244.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 2e-125, bitscore:
                     417.5, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-07, bitscore: 31.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPEGPVPFRTFILKVANRCNIDCDYCFVFNSRDQAARRLPARM
                     DLAVARAAARRIGEHASAHRLRAIHVVLHGGEPLLVGVGHMAGLFQAVRDSVPAGTRVL
                     FELQTNGTLLSDAWLDLFERYEVAVGVSLDGPPLANDRHRLTHAGRSSAASAVRGIELL
                     RSRPHLFAGLLAVVDLANDPVEVHDYLAAFEPPVIDFGLPHATHDDPPHRSDPSVPEYG
                     LWMSRVYDAWLDRPEYRHSVRMLEDIVALSSGVRGSVETLGLAPPTSVVIESDGSIEAV
                     DTLRSVEEGATWLGLDVLRHSFDEALSHPKLLHRQHGKEALAEQCRACPLVDVCGGGYL
                     PHRFSEAQGYQNPSVYCADLEYLIRHVQGSLRQHGWNPYAQAASSP"
     gene            11471..11950
                     /gene="haaN"
                     /locus_tag="M878_RS67910"
                     /old_locus_tag="M878_19335"
     CDS             11471..11950
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene="haaN"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142306.1"
                     /locus_tag="M878_RS67910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19335"
                     /product="cyclophane-containing RiPP N-acetyltransferase
                     HaaN"
                     /protein_id="WP_023547805.1"
                     /transl_table=11
                     /translation="MTVTIRPAEKRDVPAVAELIEEIERFYGATDTDIQPIEERRLQVE
                     EALFGVPPLASALLVEDETGDILGLAAYSFLWPAAGSSHSLFLKELYVRDTLRRQGIGA
                     RLMDELRALAAARPGCSRVEWMADRDNPGARAFYESRGFTESEGKIVYRVDSGTA"
     misc_feature    complement(11517..11531)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(12418..13641)
                     /gene="fxlM"
                     /locus_tag="M878_RS67915"
                     /old_locus_tag="M878_19340"
     CDS             complement(12418..13641)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063718.1"
                     /locus_tag="M878_RS67915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19340"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_023547806.1"
                     /sec_met_domain="PCMT (E-value: 1.1e-36, bitscore: 125.6,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTTGASPEDLRNRLVDAILKEDLSGLRDAHVESTMRTVPRHAF
                     LPDAPIEEAYANKSVTIKENPDEDALPLSCASQPDIVHFMLVQLAVREGDNVFEIGAGT
                     GYNAALLKHLTGKSGQVTTCDIDPDVTAYARRTLDANGYEDVRVVTRDGALGAPEFSPY
                     DRMIATVGMWDLPGAWWDQLAVGGRLVVPLRWRGLSRAVAFQREEGRMRSDSVKMCGFL
                     PVIGQDGERNDYIDDDRLVRLYWDEDQSIAPELLRDALTRPKSVVWTDVTVGPVESFDG
                     VWLRLSATERVTCRITAKPAAVEAGLHRPASPALSPALVEGDSIAYLTLERTAEDPGAE
                     PRFRLGAVGYGPAGADLAERICAQIRAWSPARTAEPLVTAYPADTPDSDLADGAVIDRP
                     SVRLVIAY"
     misc_feature    complement(13683..13698)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.53"
                     /tool="antismash"
     gene            complement(13729..14904)
                     /locus_tag="M878_RS67920"
                     /old_locus_tag="M878_19345"
     CDS             complement(13729..14904)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063717.1"
                     /locus_tag="M878_RS67920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19345"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_063750654.1"
                     /sec_met_domain="LANC_like (E-value: 2.4e-43, bitscore:
                     147.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYDAPPTPTGPGWGQSLHSGAAGVALLHAVRAHTGEDDRDALRP
                     WAAAMLKGPIQAAAEACGLYEGAPAVAYVLSFTHTNTATRALATLDTHIADVTRQRLKR
                     AYARIDRGALPTLGEFDLISGLTGLGVYHLHRGHKTELQDVLAYLVRLTEPITFEAQRL
                     PGWWTGDSPDLRPTPRWPGGHGNFGLAHGITGPLALLATALRHGKTVPGQTQAITQICD
                     WLDRWRNGTGSRAWWPDLITRAEHRRGELQRPGPRRPSWCYGTPGIARAQQLAGIALGD
                     RDRQRQAEQALAGCLADDQQLAQLTDASLCHGWAGLIQTVSRAAADALDDELASHLRRL
                     NVRLNKHLDHHGLPDGAGLMDGTAGIHLVRLTDPVNTAITAPWDRCLLLTG"
     gene            complement(14904..17954)
                     /locus_tag="M878_RS67925"
                     /old_locus_tag="M878_19355"
                     /pseudo=""
     CDS             complement(14904..17954)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="M878_RS67925"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19355"
                     /product="lantibiotic dehydratase"
                     /pseudo=""
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.9e-208,
                     bitscore: 690.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.1e-16,
                     bitscore: 60.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-06, bitscore:
                     27.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGSDGKLYQHTGAALLRAAAMPLTGLPTWWPDPSDTEACGRWLKQ
                     VWADARFADAVRQASGDLATRVDAICTGQRTRSKQVRRAAMATVRYLLRATGRPTPFGL
                     FAGVTAASVGSTPHVRWGDTHQAVARVDTEWLDNVIVRLEACPALLERLDVVLNNLATR
                     RGGRLHVPHGGPMGATVRRTSAVRVIERLAGGPVRFAALAEQLAASFPRTEPQNIRTLL
                     GALVREKFLITSLRAPMTNTDPLSHLIDRLHGADAGTVPQVAQVLHELEAVQRAVHGHN
                     RRPASAQGLAREELTGRLRGLSEAGRSPLAVDLRLDAEVRIPESVAQEMERAADALLRL
                     TRRPAGQGVWKEYQVAFWERYGTGTLVPVKEVVDPASGLGYPAEYPGSRMTAPPPTVSE
                     RDERLLALAWQALADGSREIVLTDDLIDRLAGDAPTGQEAPPHVEMCARLHADSLSALE
                     RGDFTLTVTPARAAGTLTSRFTPVATGTGLDEIYRQVPTGVENALTAQLSFPPLYPRTE
                     NVARIPAYLPHVIPLGEHHGPDDTSTTLIDVDDLAVTATHTRLYLVSISRRRLVDPQVF
                     HAMALDKQPPPLARFLAHLTRSFGPAWSGFDWGPHGARLPFLPRVRYGRVILSPSRWNL
                     TADDLPSYGADMREWSDALGRWRKLWHCYGAVELREDDRTRRLQLDVPAHATVLRAHLD
                     REGHAVLTEAPAEETYGWIGGHVHEIALPMTSTRPPIPDPLSGFLPVLTNSTLGPVPGA
                     VQAPWLNAKIYSHPEQFEELIGTHLGRLVAQLPGTPEWWFVRYRTPHDLDHVRLRIRTR
                     SPGQYAACAELVAGWAAGLRR"
     misc_feature    complement(15252..15254)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(17241..17492)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M878_RS67925_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="3.30E-19"
                     /identifier="RREFam001.1"
                     /label="M878_RS67925"
                     /locus_tag="M878_RS67925"
                     /protein_end="238"
                     /protein_start="154"
                     /score="60.3"
                     /tool="antismash"
                     /translation="VVLNNLATRRGGRLHVPHGGPMGATVRRTSAVRVIERLAGGPVRF
                     AALAEQLAASFPRTEPQNIRTLLGALVREKFLITSLRAP"
     gene            complement(18034..18237)
                     /gene="fxlA"
                     /locus_tag="M878_RS67930"
                     /old_locus_tag="M878_19360"
     CDS             complement(18034..18237)
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063715.1"
                     /locus_tag="M878_RS67930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19360"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_023547810.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.1e-09, bitscore:
                     37.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATMLSPITTATTGASAATAAPEAPADPFDIDLTIVTEIGADLL
                     PKACGTGDGCAASCASSCASAV"
     gene            complement(18423..18590)
                     /locus_tag="M878_RS97535"
                     /old_locus_tag="M878_19365"
     CDS             complement(18423..18590)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676477.1"
                     /locus_tag="M878_RS97535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19365"
                     /product="hypothetical protein"
                     /protein_id="WP_023547811.1"
                     /transl_table=11
                     /translation="MRQRSLLQLLDQVGWVLRHPATYVGRFGFGTFQVLFLPVLVTGTT
                     LTTLYAGQSR"
     gene            complement(18599..19006)
                     /locus_tag="M878_RS99955"
                     /old_locus_tag="M878_19370"
     CDS             complement(18599..19006)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M878_RS99955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M878_19370"
                     /product="hypothetical protein"
                     /protein_id="WP_245238125.1"
                     /transl_table=11
                     /translation="MSSSARQTAPHEVPPGTRLVLYACLPASLGEAADHSVASARRYVA
                     DAGWEAVETHVDRAAPFESRALCEGWHNALAAVEQGKAAGIVTPLLVMLGHLEGDRANL
                     AAWQARTGALITTPWAVVDAAGATVARRSAA"
     gene            19219..19779
                     /locus_tag="M878_RS99960"
     CDS             19219..19779
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="M878_RS99960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_245238128.1"
                     /transl_table=11
                     /translation="MDAVDEERLCRRTPVRRHWVKLADCTEPSGLARRHVREFLDGRAA
                     PERVDDAVLIASELVGNALRHTAGGPDCMCVEVYRNVAVLRVHDAGRDVSRVQARSPEE
                     SVDQLTGNGLGLLLVGELASAWSVRPTAIGKEVVVILALDAGGLPERDALPHIPTVRPP
                     LTAELHQLDGGHGEFDSRKSAKP"
     gene            complement(19660..20364)
                     /locus_tag="M878_RS67935"
                     /old_locus_tag="M878_19375"
     CDS             complement(19660..20364)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063714.1"
                     /locus_tag="M878_RS67935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19375"
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_023547813.1"
                     /transl_table=11
                     /translation="MPLLSVDPAAFPAEPPADTHDPAVTAAHDWAAFSALDEMTDHWAR
                     PGWSDGSRAYYWMLTFPDDQRLATLAGHCQEELTPLGLDPVPTDGLHITLARVGTPDVV
                     TPGQLDSLARDAEALLPSAFSVHAMPLAGSRGAVRLSLGPWEPLLRLHHALAKTGSSVG
                     LAPKKPTSAFRPHLSLAYNNRRRPAAPVVETVSGLRALPAVELSVSAVQLVELRREGRT
                     YRWDVRKSVTLG"
     gene            complement(20420..21760)
                     /locus_tag="M878_RS97540"
                     /old_locus_tag="M878_19380"
     CDS             complement(20420..21760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063713.1"
                     /locus_tag="M878_RS97540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19380"
                     /product="hypothetical protein"
                     /protein_id="WP_031225205.1"
                     /transl_table=11
                     /translation="MPRTTLLRQLLQQRHLTTHEAFAGQYERAAARLAELDRDPRLASL
                     QVSPRQFDRWYGGELLTLPRPDACRVLEHMLGRPVSELFSTAYDGDSAHDRDEESSTGQ
                     QATSAPPPREDDENPLDIVTRTRQLTASNADDAMLAFLDSSLEGIASRYEQDGPYVLRP
                     QARQVRQLAHTLLDGRQPPRTRRELFRLAARASGLLGYMAVNTGDFALSAAYCTEARDL
                     SREIGDLDTDLWACGTLSFSLYYAGRYDEADACAAAAVERAPRHAQCIRLLANGRARAL
                     GKTGDRRAVEQAIGQALRLSDLHEVPVGLTSCISFEPYGRARTLANAVTSHVALRNTAQ
                     VLRDAELIDDLVEHSASSWSRSLVRLDVAAALLQQRTPDVDHAMALGREALRLCGDTPI
                     SSVYQRSRDLHEQAGPWRDHPAVRDYGDEFRTWSSQPAALAMASSAS"
     gene            21982..22863
                     /locus_tag="M878_RS67945"
                     /old_locus_tag="M878_19385"
     CDS             21982..22863
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019063712.1"
                     /locus_tag="M878_RS67945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19385"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_023547815.1"
                     /transl_table=11
                     /translation="MALKRSLVPQSVYRRQLAARLKELRDATGLTLTEVADQLEVNQGS
                     LSRIENGERGTTPVLVRALLDLYGVKDEDRRADVLDLVRADKEQQKPWWRKYSTVLTPT
                     RYDGYLALEAGATHLASYQPMLVPGLLQTEDYARAVISQMRKDLSPPQVESLVRVRMER
                     QNSRLGGEAPARLWAILDEAVLRRTVGSVEVMRDQMRKLVEASERSNVTVQLLPFSLGA
                     HPGLYGPFVILTFPPPTPDLVWLENPKNSVYLESPEDVENYTDIFDQLRSTALDPSETR
                     TLIARISKELEE"
     gene            22860..23117
                     /locus_tag="M878_RS67950"
                     /old_locus_tag="M878_19390"
     CDS             22860..23117
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018561635.1"
                     /locus_tag="M878_RS67950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_19390"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_023547816.1"
                     /transl_table=11
                     /translation="MSTPSTSAPHDVTTAPHDADLAHARWRKSSYSGGANDCVEVAALG
                     DRAAVRDSKDISRGPLLFSKAAMRALVSGIACGSVSERWS"
     misc_feature    23898..23907
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    27035..27049
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.1"
                     /tool="antismash"
ORIGIN
        1 tgtgttgtag cttcgccgtc gccagcgcgt caatggcttc ccgatgtgat gcttctggct
       61 cggtcggcag ggcaactatt tggtcaaccg gcgatcgtgc cctacggttt tggtcccgcc
      121 ctctaccagc ctgatttcct gcggcctttc tgccgtgaga gattgcgccg gatcgggctg
      181 gacttgcgcg gcccgggtgt ggctatgttg acgacacctc cggaaaacgc agtcgactcg
      241 cggcgcaccc cgcgccaaca gcccgacccc tccgttcgaa tcccgccccg accgacggtg
      301 agccgtggtg tccgcccaca ggccgccgag tgaggaccgc cccgctcttg gcacgaatcc
      361 gcaccatcaa gcccgaagcc ttcgtctccg agtccctggc caccgtctcc ctgaccgcgg
      421 aacgcacctt cctcggcctg ctcacccaag ccgacgacca gggccgccat cgcgaccacg
      481 ccgcgatcat cgcgggccag ttgtgggtcc tgcgcccgga acacacgcca tccgatgtcg
      541 agacggacct cgcccagctc gccgacgccg ggctgatctg ccgctacaag gggccggatg
      601 acaagcggta cctgcacatc gtcacctggc accagcacca gaagatcaac cgacccagca
      661 agagccgcct cccctcctgc ccccaccacg acacaccggt cggcaccgcg ccaggcgtcg
      721 ccgcgccgac tgcgcgggcc agcatcacgg agcccgcacc gcagcctcac ggagccctcc
      781 gtgaatgatc cgggcaagtg cgcgagcctg cggtgaatcc cagcgctgat gacgaagccg
      841 caggtcagat cggcttcacg gagccctccg tgagggggcg gggaggactc agtgcggcag
      901 ccgtgacgcc tcacggttcg gatctaggac ctaggatcat ggatctagga gatacccctt
      961 cggggggcgc gagcgccccc gcacccgaca ccgtctcggc ccagcagctc atcgccgagt
     1021 acgccgccgc ctgcgcccac cgcccgccca aggacgtcct gggccacctc ggccgggagg
     1081 tgcgcaagct cgtcgacgag ggcatcgccc ccgcccatat ccgggccgga ctcgaacggc
     1141 accggaccaa ggggctgcac cccagcaccc tgccgagcct cgtccacgag gccatgaacg
     1201 cgacctccgc cacgccaacc gcgccggtta tccacagggc gtggacaaat ccgaccgatg
     1261 tcgaagccgc cttcggaggt gacctctgac cgccaccctc acccgagagc cccaccgggt
     1321 cggcccgctc gccgaccggc tcaacggcat cttggccagc cgcggcatcg accctggtgt
     1381 cacaggcgag gaaccaccgg cggagcctgt cacggccctt gagctggcgg acgcccgtat
     1441 ccccgcccgc taccgccgcg ccatggctga ccagccgcag gtcagcgcct gggctgacga
     1501 gatcgcccgc gctggacgcc ccggccccgg tggacccggt atcgcagaag gcccgtcgct
     1561 gctgatcgcc ggccccaccg gcaccggcaa gacatatcag gcgtacggcg ccgtctgcgg
     1621 cctcctcagc cgtggcgtcc gcctgcgctg ggaagcgacc accaccgccg accttcacgc
     1681 gcgcatccgt cctcgtaccg gccacgacgc cgaacgcgac ctacagacac tggcccgctg
     1741 cccgctgctg ctcctggacg acctcggtgc agccaagacc agcgagtgga ctgaggagct
     1801 gacctaccgg ctgatcaacc accggtacga gcacatgctc cccaccctca tcaccaccaa
     1861 cctccctacc gcagagctcc gcgccaccct cggcgaccgc gtcgcctcgc gcctcgccga
     1921 gatgaccgaa cgcgtcgtcc tcaccggccc cgaccggcga cgccacaccg cggccaccgc
     1981 ctaaccggcc accccagccg ccttcccctg ccctgcctcg ctgcaccgct cgcgctcaca
     2041 cctgccctgg cccgcgcaga ctcatcgcgc aggggcactc agcactccgc cgcgttcgcc
     2101 ctcctcttcc ctctacacct tggagaccca ccctgcttcc actcctcttc gcgcccctcg
     2161 ctgcccagag cagcggcacc ccgctcctgc cggactgggc cacctcctcc acgatgactg
     2221 tggtgctcct cgtcctgctc gtgctatccg ccctgttcgc tggatggacg atccgccagc
     2281 agcaccgccg gccgtccgcc accaaccgct ggcgcgggac catcgccgtg cccgtcgcgg
     2341 ccatggccgc gatcggctgc accacctaca gcgcggacac cagctggcgg ttcgccgccg
     2401 actacctcga catgggcggc accaccgagc gtgtcgcgat gttcgccgcc gccgagctcg
     2461 ccctgttcgc caccgcgctg atggcacgcc agaacctcaa cggcccgaag caggcgcccg
     2521 gtacgcccgg aaccctcacc tgggtcatca ccgccgtcca gatcctgccc gcctacgccg
     2581 agtccgggct gctcggcggc acagtacgag cctttgtcgg ccccgtcctg gccgcgattc
     2641 tctggcacct ggccatgggc atcgaactgc gccatcgcac ccccgacgcc acctcacgca
     2701 gcctggccgc catcctcgtc cgccaggcac gtgaacgcct gctcgcccga ctcggcatcg
     2761 ccgaccagga cgccgatgcc gcccgactca tccgcgagcg cgcgctgacc gaagccgtcg
     2821 ccctgatcct gcgcgccgag tcgatgaccg acaagaagcg cggcaaacgg cggcgacgac
     2881 gcctgacaga gcgcctgcac caggctctgg agcgggccga tgtcgacggc gatccgctcc
     2941 aggacgagct gctgctgcgc aagctcgcca cgcgcaggca ggccctcggc ctcgcctccc
     3001 tcatactgcc gccgcgctgg caggccccgg cctcgtatac cgcccgcgaa tccgggcaga
     3061 gccgccaggg ctccgcccgc ccggcgtcag tgccacgggc agagcaggac gctgcccgcc
     3121 cgcacccagc agacccgggc gacgacgagg tgcctccggc tgcccgcctg cggcctgccc
     3181 gttcggcgcc agggctgccc gcccgggcag acaccgaaga cagcccgccg ctcacgggca
     3241 acacctcggg cagcgctccg ggcaggcgcg agcggaaacc ggctgcccgg aagaagcgca
     3301 acgacggcaa accccgcgcc tccgacgagg tcatcctcaa gtacacccgc cgcatgtacg
     3361 aggagaccgg cagcgtcgga cgcgaccggg tggaggacgc cctgcgcgtc gatgactaca
     3421 ccatttccag tgatgacgtc ggacgagtcg tccgtgactt caagggccag gtcaaggccg
     3481 aagccgacgc tgcacctcgg tgatcccctc agcaccaacg ctccccacca cgcccctcac
     3541 ggaaggcccc atgtactctc cgcaccaccc agaccccacc acccacgagg actccctgcc
     3601 gatcacccct gccccaggcg gagcaagttg gaggtccgga cactcccccg cagggggagc
     3661 gcccgaaccc gaccccgccc tgggggtggc ggggtccgtc cggcaccagg gggcgccgga
     3721 cgggaaagct gcgaccgagg acggaccgca gccaggcaag gccagcccga agggcgaggc
     3781 caggaagggg aagtcacgtc cgcgcgacaa aaagcagcgc cccgcccaca gcgtccgcct
     3841 caatgaacaa gaactcgcca tcatccagtc cggcgccgac cacgtcgaca tgagcgtggc
     3901 cgggttcctg gcccactccg ccctggccgc cgcccgcgac cagtcccgca ccgccgcggc
     3961 catcgcgacc gaacgggaca tcctgacggc cctgttcggc gtgcgccgtc agctcggctg
     4021 ggccggcagc aacgtcaacc aggccgtcaa ggcactcaac tccggtgccg acgcactgca
     4081 cttcgccgct gccctcgccg acctgcaacg cgccgcacag gccgtccagc gagcggccga
     4141 caggatcacc aaccgacagg aggaccaggc ggcttgatcc cccggatcca cgagcagggc
     4201 agcaacaccc tcgggctcct gcactacctg tacggcaagg gcacccacga ggagcacatc
     4261 gacccgcacc tggtcgcgtc cttcgacggc atggcccccg accccggccg cgacccttcg
     4321 gtcacgaaga aggacctcca gcacctcctc gaccagcccc tgtccctgct cgctgcggac
     4381 cagcgccccg cccagcacgt ctggcactgc tccgtacgcg ccgcccccga cgacccgatc
     4441 ctgtccgacg agcagtgggg tgacatcgcc cgccgcatgg tcgccgccac cggcatcgat
     4501 cccggtgacg gcgccggctg ccgctgggcc gccgtccgcc acgccgatga ccacatccac
     4561 atcatcgcca ccctggtccg cgaggacggc cgccgccccg atcaccaccg ctccggcaaa
     4621 cgcgcccagg ccgagtgccg cctgattgaa aaggaactcg gcctgcacca gatcgcgccc
     4681 ggtgacggaa ccgctgccaa gcgggccacc agtgccgagc ggcacaaggc cgaacggcag
     4741 ggcagggagc gccccgcgcg ggaggagctg cgggagaccg tacggcgcgc ggtggccggc
     4801 gccgccagcg aggaggagtt cttcgaccgc ctggccgccg ccggtctgct gatccgcaag
     4861 cgcgtcgcgc cctccggtga tctgctcggc tacaaggtcg ccctccccga cgaccgcaac
     4921 aaggacgatg agccggtctt ctacgccggt tccacactcg cacccgacct gtccctgccc
     4981 cgcatccgcg aacgctgggc cctttccgca gaggctgccg cctcggcgga cggctctggg
     5041 ccggagcagc ccgccctgcc ggccgtgaca ggtcccgcgt tcgctcggcg ccgggccacc
     5101 gacgccacgt ggcaggccct gctgatcatc gaccacggcg acgacggcac agcagcggcc
     5161 cagatcgccg ctgcagggga gatcctggac gcgctcgcca agacctccgc cgcgcacacc
     5221 cgcgctgaac tccgcaaggc agccttcgcg ttcgagcggg ccagccgctc ccacatcaag
     5281 gccgtacggg ggcacgacca cgctctgcgt caggccgccc gcgatctcgt ccacagtggg
     5341 cccgccctcg gccgcggcga ggatggcgcc accaccgcca tgctcatcga catggccttc
     5401 ttcctcgcga tcgccgcggc gaactggcac gccaggaagc accacagcca gcaggccgcc
     5461 gcagcccggg aagccgctga acaccttcgc gccgcctacg aagccgctgc ggccgggtcc
     5521 atggccatcc tccgccagcg aggccatcgt ctggcaccgc gtgtccggca gcggcaggcc
     5581 ggccttctcc accaagtgct gccggagcag gccgaacagg tcttggccga ggccgactgg
     5641 cccgccctgg ccgccaccct cgacgacgcc cagagagccg gccacgaccc ggccgccctg
     5701 ctcaccgaag ccgcccagcg gcgcgagctc gacactgccg actccatcag cgacgtcctc
     5761 gtatggcgcc tgcgccgcag cgcccacctg cccgccctgc ccgaaagccc ccgcgactca
     5821 tccgcccgcg gcaaccggcg cacaccctcc ccggcgccca ccacaccggc ggcgaccagc
     5881 gcagtgaacg actcccgcca ccagcgctga ccgggaaaaa cggcgaaaca tagccgacga
     5941 tcgccggttg ggcaaaccgg cgatcctccg gaccattgat gcctgcaccc acccgactcc
     6001 cgtataggag cacctatgcc cgaaaccgac atccgacccc gactcgacat cgtcgccctc
     6061 ctgtgcgacg cggacttcaa gtaccggcct gacaccaaca cctggagcca ccgcgacgga
     6121 cgcccgttca gcaaggagga acaggccctc accttcaccg ccacccgcgt cgaattcgaa
     6181 gaggtgagcg aacagctcgc gcggtacagg gagtaccggc gtacatggga ggaagcgtcg
     6241 gaagccttcc agcgtttcct cgccccgttc atggaacagc tcaccgagaa gaacctcggc
     6301 aacgccgtcc agctcatgag cgagaacgac cgcatcgagt tcgaccggct gcttggcctc
     6361 atgatccacc cgcttcggcc cttcaccccg aacaccttct gacgacggcc cgcgtcccgc
     6421 cacgaccaat gtgaggaagt gaccgggcca gggggcagat cccggaatct ccggcaccca
     6481 ggcacgaagc cgggcctccc caacgggagg cccggcttcc cagcgtgaga agccctcagc
     6541 cagctggagc gcgcaagagt cggtcgtgtg tgctctccga cagcacccga cgcagcaccg
     6601 gtgcgctgcc actgagggag tcggcgaacg cggcgacgag gtcgtgcggc acgctgccgc
     6661 tgaacgagac tggcagggtg atcagaaggc ggcctgggtc ttgtcgagcg ccttggccag
     6721 gttggcgtcc acgagccccg gcgagccgga gacgatcacc aggaccttgc cggtgcggat
     6781 cgccgtctgc ttgacgatgc tgcgctgccc acgaacggag taggtgagca gctgactcca
     6841 ccgctcgtcg cccaggtcgg gggccgccgt cacctgccgt acccacgttg ggccggtggg
     6901 gaagcggcca ccgcgccttg cggaagctgg tgcacgccgt ggctcagacg cgcccttgac
     6961 caaggtctac gaggactgtt ccgttaggga agttggggcg ttctactcgg gggttgcctt
     7021 cgtgaccagg tcggttggca gtgcgtggtg cgtcattagc ggcaccaggc aggaatcggc
     7081 cgttccctcg gctgctgggg cctccgcatg agactccggc gcgggatcgc gatcgccgtc
     7141 gtcgccggag gcggcgctgt gaccacgctg ctggtcggac tcgtcacgaa cgccgtgtcc
     7201 aacaagtcgc ggtggcccgg ctggctgggg tggttacagg agcacgcctg gttctcgttc
     7261 gtcgtgttgg gcgtggcaat ggctgggctg acggccctgc tcgccgggct ctccgagacg
     7321 cggcctccca gcccgccagg gcgaccggag gatggagcag ggccaggggc cgcccaggtg
     7381 ctgcgttcgt tgccacgcga caccgccgcg ttcaccgacc gtgccgcgga gctggagcgg
     7441 ctggtgggct cggtgcgggc ctcacaggag cgtggcgagg gggtgcccgt tcacgtgatc
     7501 gacggcatgc ccggcgtcgg gaagaccacc ttcgctgtgc acgccggcca cctgctctcc
     7561 gagcggttcc ccgacggaca gctcttcgtg aacctcaacg ggtacacgcc ggggcgtact
     7621 ccggtacagg ccagcgaggc gctcgcctcg cttctcacgg ccgccggcgt gccgacgcag
     7681 cagattcccg tcggtgacgg cgtcggagcg gtcacggagg ctcgggccgc catgtggcgg
     7741 agcaggctcg cgggcaagaa ggcgctgctg attctcgaca acgcggccag ctaccgacag
     7801 ttggagccac tgctccccgg tgggagcggg tgtctggtgt tggtgaccag tcgcaagcgg
     7861 ctggtggcga acgaggaggt ggtcatgtcg gtggacgcac tgccgccgga tcacgcggtc
     7921 gaactcttcg tacggctcag tgggcggccg gccgacgctc tcgaccggga tgtggtggac
     7981 gagttggtgc ggctgtgcgg gtgtctgccg ctgggggtgt cgcttctcgc ggcacggctg
     8041 cggcaccatc cgtcctggac cgccgaggac ctgcgcgggc ggctggtgac ggcacaggac
     8101 cgcctgggag agctgcgcgc cggggaacgc gccgtcaccg cgacgttcgg tctctcctac
     8161 cgggatctcg caccggaacg gcagcgcttc tttcgacagc tcggcttctt tccgggcacc
     8221 gatctcgacg cgcacgtcgg tgcggcactt ggtgaggtct cggtcgtggt ggctcgtctg
     8281 caccttgagg cgctctacga cgaccacctg atcgacgagc acccggggag tcgctaccgg
     8341 ctgcacgatc tcttgcgcga ctacgctcgc ggtctcgccg ctgagggaga cagcatggac
     8401 cacgcacagg ccgtccagcg tgtgtgcacc tactacctgg ccgctctcgc cgtcgcgaac
     8461 gagcacatcg tgcgcagcgg agccgcggtg ccaccggcgc cggacggtgc ctcgcgggtg
     8521 gagaccccgg tcctggagtc gcggacggat gccctgagct ggctggagac cgagcgggcc
     8581 accatcctgg cctgcgtccg tcgggcgaac ggccttgccc tgtacgccct cgtggcccga
     8641 ctcgccgcag ccatggcgcc cttcctgcgc caggccggcc cctgggacca ggccgtcgcg
     8701 ctccatcgga ccgccgccga agccgcccgc cataccggcg accagcgggc gcggggtgat
     8761 gccctcgccg agctgggtgt cgtacgccgt ttcatggccg cctacccaca ggcgatcgag
     8821 gccctcaacg acgccgtgac ggcgtacgaa gcggtcgacg atcggcgtgg caaggccgag
     8881 gcactgaacc agctcggcat cgtctggtac ctgaccgcgg acaacgagga cgcggcccgc
     8941 gcccagaccg aggccctcgc cctctatcga gagctggggt accggctcgg gcaggcgaat
     9001 gcgctcgcgg atctcggcat gacacaccgg cagatgagcc ggttcgacgc cgcggtggag
     9061 gcccagaccg aggccctgtc gatctaccga gaactcggtg accgatacgg agaggcgaac
     9121 tccctgcgcg acctgggcgt cgtgcacagc ctcatgggcg cgtacgacct ggccgcgcgg
     9181 catcaccagg aagcgttcga catctacctg gagctggacg accgtgtgca ccaggcttac
     9241 gcgctgaacg agttgggcgt cgtccgacgg ctgaccggag acatcgaggc agcgcggacg
     9301 gcacacagcc aggccctgac gcacttcacc gagctcggtg aacggttcgg ccgcgcgaac
     9361 agcatccgtc accttggcgt cgtggagcgt gtgaccgggg atgcggcaga ggcgatccgg
     9421 cttctggagg aggccctggg cgcctaccgc gagctcggca gccgaggggg tgaggccgcc
     9481 tctctgagcg agctgggcgt ggcgcgcggc atcgtcggtg agcgcgacgg cgcgatcgag
     9541 gcgttccaac gcggtttgga gatcctgagg ggcctgggcg accggtgcgg cgaggcggag
     9601 gcactgagcc actgggggat gctgctgctc acctccgatg aaccgacagc cgcccgtcgg
     9661 cactttggtc aggcgctcac gctcgcgcgg gacatccgct gcccgctgga ggaggcgagg
     9721 gcgctggagg gcatcggccg ctgcgactgg acggttgacg ggcctggtca cggcgtgagc
     9781 tcgctgcgag ccgccgtgac cgtgtaccgg cgtttgggag tgagcgcggc cgtggacgac
     9841 atcgaacggt tgctggtgtc gcggtccggc tgacgccgac catgtggccg aatttcctgt
     9901 gccaggtggg tggttgagga tgctacgttt ccggctaatc tgtcgcttca cccccgtcgc
     9961 accgtgccac ctccggcacg tacctcacga ggagcgttgg atgccgtcac ccacgtccgt
    10021 caccgagcca cgcaccatca cgcccgtcgg cccggcgtcc gcggagccga cggcggccgg
    10081 caccgccgtc ctggaccgcg tgaccgcccg cgtccggcag cggctggagg ccgaggaggg
    10141 cgcgacgggc cgggtcggtg acggtgccca cgcggcctcg ctcatctggc cctggccgct
    10201 gtgagcacgt ccgctcgatg acagaacccg aaggccccgt tcctttccgg acgttcatcc
    10261 tcaaggtcgc caaccgctgc aacatcgact gcgactactg cttcgtcttc aactccaggg
    10321 accaggcggc gcggcgcctg cccgcccgaa tggacctcgc tgtggcccgg gctgcggccc
    10381 ggcggatagg tgagcacgcc tccgcacacc gccttcgggc catccacgtc gtcctgcatg
    10441 gcggggagcc gcttctcgtc ggcgtcgggc acatggccgg tctgttccag gccgtccggg
    10501 acagcgtgcc ggccgggacc cgggtccttt tcgagctcca gaccaacggg actcttctgt
    10561 ccgatgcgtg gctggacctc ttcgaacggt acgaggttgc ggtcggcgtc agcctcgacg
    10621 ggccgccgct tgccaatgac cggcaccggc tgacgcacgc cgggcggtcg agcgccgcct
    10681 ccgccgtgcg cggcatcgaa ctcctgcggt cgcggccaca cctgttcgcg gggctgctcg
    10741 ccgtcgtgga cctggccaac gaccccgtgg aggtccacga ctacctggcg gcgttcgaac
    10801 cgccggtgat cgacttcggc ctgccgcacg cgacccacga cgacccgccg caccgctccg
    10861 acccgagcgt gcccgagtac gggctgtgga tgagcagggt gtacgacgcc tggctcgacc
    10921 ggcccgagta ccggcacagc gtccggatgc tggaggacat cgtggccctc agctctggcg
    10981 tgcgcggctc ggtggagacg ctcggcctgg ccccgccgac aagcgtcgtg atcgagtccg
    11041 acggctccat cgaggccgtg gacaccctgc ggtcggtcga ggagggtgcc acctggctcg
    11101 ggctcgacgt cctccgccac tccttcgacg aagctctgtc ccatccaaag ctgctgcacc
    11161 ggcaacacgg caaggaagcg ctcgccgagc agtgccgcgc ctgcccactt gtggacgtgt
    11221 gcggcggtgg ctacctccca caccgcttca gcgaagccca gggctaccag aatccgtctg
    11281 tctactgcgc ggacctggag tacctcatcc gacacgtcca gggctccctg cggcagcacg
    11341 gctggaaccc gtatgcgcag gccgcctcgt cgccgtagac gcgtgtgccg taccgccagg
    11401 aggggatcac gcgttggaac gaacgagtgc agcagcgacc gaagcaatcg aggaaggaca
    11461 ggaggcgccg atgaccgtga cgatccgtcc cgcggagaag cgggacgtcc cggccgtggc
    11521 cgaactgatc gaggagatcg agcggttcta cggggcgacc gacacagata tccagccgat
    11581 cgaggagcgc cgcctccagg tggaagaagc cctcttcggc gtgccaccgc tggcttccgc
    11641 cctgctcgtc gaggacgaga ccggggacat tttgggcctc gccgcctatt ccttcctctg
    11701 gccggccgcc ggttcctcgc actccctgtt cctgaaggag ctctacgtcc gcgacaccct
    11761 gcgtcggcag ggcatcggtg ctcgcctcat ggacgaactc cgcgccttgg ccgccgcgcg
    11821 ccccgggtgc agccgggtgg aatggatggc tgaccgcgac aacccaggcg cacgggcctt
    11881 ctacgagtcg cgcgggttca ccgagtccga agggaagatc gtctaccggg tcgactccgg
    11941 cacggcgtga gggtggtacg aggccagtgg aagtagagcg ctgcgacgag tgcggcggca
    12001 agatagtcat cgggctcgga tgcgagtgtc cgccgggctc gtcggcgtcg gcgcccccgc
    12061 gttcggtagg cacgttcgtg aagaggaggt ggcgtactca cccggatgac acgatcctga
    12121 tctccccgac gcagtgcgcg cacaggcccg gctggtgcga ccacatgacc gaggacgatg
    12181 tacgaccccc gcggtggggg tggatcccga atcctccacc tgggctctgg gagcggttga
    12241 gcagtgcttc tccggcgacc gccaccgcgg gcaatccgag gcgacgggct gtgcggcggt
    12301 gcaccgactg ttaggcgaac ctcgcgcagg gctgaccacc gtgctccgac gccgcgctgt
    12361 tctcgtttcg gtgggcgcgg ccgcacctgc caacggccac gcccgcctgc gtcgggatca
    12421 gtaggcgatg acgagccgca cggagggccg gtcgatcacg gctccgtcgg cgaggtcgct
    12481 gtccggtgtg tccgcggggt aggccgttac caggggttcg gcggttcggg ccgggctcca
    12541 ggcgcggatc tgcgcgcaga tccgctcggc gagatcggcg ccggcggggc cgtagccgac
    12601 ggctccgagc cggaaccggg gttctgcccc cgggtcttcg gcggtccgct ccagagtgag
    12661 gtatgcgatg gagtccccct cgacgagggc ggggctcagc gcgggtgagg cgggccggtg
    12721 gaggccggcc tccaccgctg cgggcttcgc ggtgatgcgg caggtcactc gctcggtggc
    12781 gctcaaccgc agccagacgc cgtcgaacga ctcgacgggg ccgaccgtca catcggtcca
    12841 gacgaccgac ttcggtcggg tgagcgcgtc gcgaagaagt tccggggcga tggactggtc
    12901 ctcgtcccag tagagcctga cgagccggtc gtcgtcgatg taatcgttcc gctctccgtc
    12961 ctggccgatc accgggagga agccgcacat cttgacggag tcggaccgca tccgcccctc
    13021 ctcgcgttgg aaggccacgg ccctggagag cccgcgccat cgcagcggga ccacgaggcg
    13081 tccgccgacg gcgagctggt cccaccaggc gccggggagg tcccacatgc caaccgtggc
    13141 gatcattcgg tcgtacgggc tgaactccgg ggcgccgagg gcgccgtccc tcgtgacgac
    13201 gcgaacgtct tcgtatccgt tcgcgtccag cgtccggcgg gcgtaggcgg tcacgtcggg
    13261 gtcgatgtcg catgtggtga cctgtccgga cttcccggtg aggtgcttga gcagggcggc
    13321 gttgtagccg gtgccggccc cgatctcgaa gacgttgtcg ccttcgcgga cagcgagctg
    13381 gaccagcatg aagtgcacga tgtcgggctg ggaggcgcag ctcagcggga gtgcgtcctc
    13441 gtcggggttc tccttgatcg tcacgctctt gttggcgtac gcctcctcga tgggtgcgtc
    13501 ggggaggaag gcgtggcggg gtacggtccg catggtgctt tcgacgtgtg cgtcgcggag
    13561 gccggagagg tcctctttca ggatggcgtc gaccaggcgg ttgcgcaggt cctcggggga
    13621 ggcgccagtg gtggtgttca tcgcgtcctt tcggaaggtg cccggctgtg cgtacgacag
    13681 gggtagatcg ttctcatttg ttctggtgtg cggatgcggt tcgcggcgtc accctgtcag
    13741 gagcaggcag cggtcccagg gggcggtgat cgccgtgttg acggggtcgg tgagacggac
    13801 caggtggatg cctgccgtgc cgtccatcag gccggcgccg tccggtagtc cgtggtggtc
    13861 caggtgcttg ttgagccgga cgttcaggcg gcgtagatgc gacgcgagtt cgtcgtcgag
    13921 ggcgtcggca gcggcacggg agacggtctg tatgagcccc gcccagccgt ggcaaaggga
    13981 tgcgtcggtg agctgggcga gctgttggtc gtcggccagg catccggcca gggcctgctc
    14041 ggcttggcgt tgccggtcac ggtcgccgag ggcaatgccg gcgagttgct gggcgcgggc
    14101 gatgccgggg gtgccgtagc accaggacgg gcgtctcggt cctgggcgct ggagttcgcc
    14161 gcgtcggtgt tcggctcggg tgatcaggtc cggccaccag gcgcgcgagc cggtgccgtt
    14221 gcgccaccgg tcgagccagt cgcagatctg ggtgatggct tgcgtctgtc cgggcaccgt
    14281 cttgccgtgt cgcagggccg tggccagcag cgccagcggt ccggtgatgc cgtgggcgag
    14341 gccgaagttg ccgtgtccgc cgggccatcg cggcgtcggt cgcagatcgg ggctgtctcc
    14401 cgtccaccag ccgggcagac gttgcgcttc gaaggtgatc ggttccgtca gccgcaccag
    14461 ataggcgagg acgtcctgaa gttccgtctt gtggccacgg tgcaggtggt acacgcccag
    14521 cccggtcagt ccgctgatga ggtcgaactc gcccagggtg ggcaacgcgc cgcgatcgat
    14581 gcgggcatat gcacgcttga gtcgttggcg tgtgacgtcg gcgatgtgtg tgtccagggt
    14641 cgccagggcg cgagtagcgg tgttcgtgtg cgtgaagctg aggacgtacg cgacggccgg
    14701 ggcaccctcg tacagaccgc atgcttcggc ggcggcctgg atcgggccct tgagcatggc
    14761 ggcggcccac ggccggagcg cgtcccggtc gtcttcaccg gtgtgcgccc tgactgcgtg
    14821 cagcagcgcg actcccgccg cgccggagtg cagcgactgc ccccagccgg gcccggtggg
    14881 tgtgggtggc gcgtcgtagt tcatcagcgg ctctcccccg gccaggcggc ccatgcgacg
    14941 gcggactgac gggcaaggcg gcggcagatc ctctcgtcct cccggtccag gccacgcagg
    15001 cggttgtcgt gcatgtgcag caaggattcc aggacggagt cgaggtccat gctctcggcg
    15061 aggccctcgc gatacagcgc cagggccacg gcgcgacggt gccacgcttg ggcgagctct
    15121 tcgccccagc cccgggcacg aggcgtagcg cggcgaacga gttcgatggc ctggtcgctg
    15181 atgcctcgct cgacgcgagc cggagctgcg gggcggttcg ccagccaccg cattccctcg
    15241 tcggggccga gtaagccgca ggcgatgtcc accatgccga ccgcggccag cgcgcgtccg
    15301 tcgacgccgt cgactccggg gccctgcagg gcagcgaggg cgtaggccga gtcggccgtg
    15361 aacaccgcct cagcacagcg tagggcggcg cctgggccgt agcggccgat ctccggggtg
    15421 tatgtgtcga acacgagcct gctgctgagc ccctagcggc gcagcccggc ggcccatccg
    15481 gcgacgagct cggcgcaggc ggcgtactgt ccgggactgc gggtgcggat gcgcaagcgg
    15541 acgtggtcga ggtcgtgcgg ggtgcggtag cggacgaacc accactcggg tgtacctggg
    15601 agttgggcca cgagccgccc gaggtgagtg ccgatcagct cctcgaactg ttcgggatgg
    15661 ctgtagatct tggcgttcag ccagggtgcc tgcaccgccc ccggtacggg tccgagggtg
    15721 ctgttggtga gcacggggag gaagccggag agcgggtcgg gtatcggcgg gcgggtgctg
    15781 gtcatcggca gggcgatctc gtggacgtgg ccgccaatcc agccgtaggt ctcctcggcc
    15841 ggcgcttccg tgagcacggc atgaccttcc cggtccaggt gggcgcgcag gacggtggcg
    15901 tgggcgggca cgtcgagttg gagccgacgt gtccggtcgt cctcccgcag ctcgacggca
    15961 ccgtagcagt gccacaactt ccgccaccgg ccgagggcgt ccgaccactc ccgcatgtcc
    16021 gcaccgtagc ttggaaggtc gtcagcagtc aggttccagc ggctgggaga gagaatcacg
    16081 cgcccgtagc ggacgcgcgg caggaacggc agccgtgcgc cgtgcggccc ccagtcgaag
    16141 ccgctccagg cagggccgaa ggagcgggtc aggtgcgcca ggaacctggc caggggaggg
    16201 ggttgcttgt ccagggccat agcgtggaag acctgcgggt ccaccaggcg acggcgggag
    16261 atgctgacca ggtacaggcg ggtgtgcgtg gccgtgaccg cgaggtcgtc gacgtcgatg
    16321 agcgtcgtcg aggtgtcgtc ggggccgtgg tgctcgccca acgggatcac gtgtggaaga
    16381 taagcgggga tgcgggcgac gttctccgtg cgcgggtaga gcggcgggaa ggacagctgc
    16441 gcggtcagcg cgttctcgac gcccgtggga acctggcggt agatctcgtc gagtcccgtg
    16501 ccggtggcga ccggagtgaa ccgggaggtg agcgtgcccg cggcgcgggc cggtgtcacc
    16561 gtgagcgtga agtccccgcg ttccagggcg gacaggctgt cggcgtgaag acgcgcgcac
    16621 atctccacgt ggggtggtgc ctcctgcccg gtcggcgcat cgccggccag gcggtcgatc
    16681 aggtcgtcgg tgaggacgat ctccctgctg ccgtcagcca gtgcctgcca ggccagggcc
    16741 agcagccgct cgtcccgctc ggagactgtc gggggcggtg cggtcatgcg actgccgggg
    16801 tactcggccg gatagccgag cccggacgcc gggtcgacga cctccttcac cggcacgagc
    16861 gtgccggtgc cataccgttc ccagaacgcg acctggtact ccttccacac accctggccc
    16921 gccggtcggc gcgtgagccg cagtagagca tcggcagccc tctccatctc ctgcgcgacg
    16981 ctctcgggga tccgtacctc ggcgtccagc ctcaggtcga cggccaaggg acttcgaccc
    17041 gcctcggaga gcccacgcag tcgacccgtg agttcctccc gagccagccc ttgcgcgctc
    17101 gccgggcgcc ggttgtgccc gtgtacggcg cgttgcacag cttccagttc gtgcaaaacc
    17161 tgcgcgacct gcggcacagt gcccgcgtcc gcgccgtgca gccggtcaat caggtgggac
    17221 agcggatcgg tgttggtcat cggcgcgcgc aaactggtga tcaggaattt ctcgcgcacc
    17281 aacgcgccga gcagtgtgcg gatgttctgc ggctcggttc gggggaagga ggcggccaac
    17341 tgctcggcga gggcggcgaa gcggaccggc ccgcccgcga ggcgctcgat cacgcgtacc
    17401 gcactcgtgc gccggacggt ggcccccatc ggtccgccgt gcgggacatg cagccgcccg
    17461 ccgcggcgcg tcgccaggtt gttgaggacg acatccaggc gctccagcag ggccggacac
    17521 gcctccaggc ggacgatgac gttgtccagc cactcggtat ccacccgcgc cacggcctgg
    17581 tgtgtgtcgc cccacctcac gtgtggcgtc gaacccacgc tggccgcagt gactcctgcg
    17641 aagaggccga acggggtcgg tcgcccggtg gcgcgcaaca agtagcggac ggtggccatg
    17701 gcggcgcgcc ggacctgctt ggagcgtgtc ctctgcccgg tgcagatcgc gtcgacccgc
    17761 gtggcgagat cgccgctggc ctgccggacg gcgtcggcga accgcgcatc ggcccacacc
    17821 tgcttcagcc acctgccgca cgcctctgtg tcggacgggt caggccacca tgtcggcaga
    17881 cccgtcagtg gcatcgcggc ggcccggagc agcgccgcgc ctgtgtgctg gtagagcttt
    17941 ccgtcgcttc ccatgccaat gcctccgccg tcagtgctgt gaacgagcgg ggtcgggggc
    18001 ggcagcgccc ccgaccccgt gcacgggccg tcgtcagacg gcgctggcgc aggacgaggc
    18061 gcaggaggcc gcgcacccgt caccggtgcc gcacgccttg gggagcaggt cggcgccgat
    18121 ctccgtgacg atggtcaggt cgatgtcgaa cgggtcggcg ggcgcctcgg gggcggccgt
    18181 cgcagcggac gccccggtgg tggccgtcgt gatcgggctg agcatggttg cggtcatcgc
    18241 acttcctctt ctgtcggaag gttccgaagg gttcgtcgtg ctgccctgcc cgcgtatgga
    18301 ttgccgcggg gccgggcttc tgcgttcgca ccttgggtgc ggcccctctc cggttgacca
    18361 aattccgtgg gggacatgga ttcggagcat ccggagaggg gggtcgagga cacgggccgg
    18421 ggctaccggg actggcccgc gtagagcgtg gtcaaggttg tgccggtcac caggacgggc
    18481 aggaacagca cctggaaggt gccgaagccg aaccgtccga cgtacgtggc cggatgccgc
    18541 agcacccatc cgacctggtc gagcagctgc aggagcgacc gttgccgcat ccgggccatc
    18601 acgccgccga ccgccgtgcg accgtggcgc cggcggcatc gacgaccgcc cacggggtcg
    18661 tgatcagcgc tccggtccga gcctgccagg cagcgaggtt cgccctgtcc ccctccagat
    18721 gccccagcat cacgagcaga ggggtgacga tcccggccgc cttcccctgc tcgactgcgg
    18781 ccagagcgtt gtgccagccc tcgcacaggg cgcggctctc gaacggtgcc gcccggtcca
    18841 cgtgcgtctc gaccgcctcc cagccggcat cggccacgta ccgccgtgcg ctggccacgc
    18901 tgtggtcggc ggcctcaccg agtgacgcgg gcagacaggc gtacaacacc aggcgcgtgc
    18961 ccgggggcac ctcgtgtggt gcggtctgcc tcgcactgct gctcattccg cgttacctcc
    19021 agccaggtga gccgagacgc caagggtccg gcgcctcgac gaagagcctc gtcgggggca
    19081 gtcggcggcg gtacgccgtc agcacgccgt ttgtccgccg tccggcggcg cgcgaggagg
    19141 cggaggcgcg gcgtaccgcc gcggctcacg cgagacgagg ctgatcggtc cagtgccaag
    19201 cggaaacgag aagcggcgat ggacgcggtg gacgaagagc gcctctgcag gcggacgcca
    19261 gtacggcgtc attgggtgaa gctggccgat tgcaccgagc cttcgggcct cgcgcgcaga
    19321 cacgtacgag agttcctcga cgggcgagcc gcgccggagc gggtcgacga cgccgttctg
    19381 atcgcctcgg agctcgtggg caacgcgctc aggcacacag ccggcggacc ggactgcatg
    19441 tgtgtggagg tctaccggaa cgtggcggta ctgcgagtcc atgacgcggg acgggacgtc
    19501 tccagggtcc aggcgcgctc tccggaggag tcggtggatc agctgacggg caatggcctc
    19561 ggactgctgc tcgtcgggga gttggcctcc gcgtggtcgg tccggccgac cgcgatcggc
    19621 aaggaagtgg tcgtaattct cgccctggac gccggtgggc tacccgagcg tgacgctctt
    19681 ccgcacatcc caacggtacg tccgcccctc acggcggagc tccaccaact ggacggcgga
    19741 cacggagagt tcgacagccg gaagagcgcg aagccctgag accgtctcta caacgggcgc
    19801 ggcggggcgc cggcggttgt tgtacgcgag gctcaggtgc ggccggaatg cggacgtcgg
    19861 cttcttcggg gccagaccga cgctgctccc tgtcttggcc agcgcgtggt gcagccggag
    19921 caggggttcc caggggccga gggacaggcg gacggcgcct cgggagccgg ccagcggcat
    19981 ggcgtgtacg gagaacgcgg agggcagcag cgcttcggcg tcccgcgcca ggctgtccag
    20041 ctggcccggg gtgacgacgt ctggcgttcc cactcgggcg agggtgatgt gcagtccgtc
    20101 cgtcggcacc gggtcgaggc cgaggggtgt cagctcctcc tggcagtgcc cggcgagagt
    20161 cgcgagccgc tgatcatccg ggaaggtcag catccagtag tacgcccggc tgccgtccga
    20221 ccagccgggg cgtgcccagt ggtcggtcat ctcgtcgagt gcgctgaacg ccgcccagtc
    20281 gtgggccgcg gtgaccgccg gatcgtgcgt gtcggcgggg ggctcggcgg ggaacgcggc
    20341 gggatcgacg ctgagcaggg gcacccgacg tactccttcg gcttcacact gccccggagt
    20401 acgacgacac cgacggcgcc tacgacgcgg atgacgccat ggccagggcc gctggctgcg
    20461 agctccaggt ccggaactcg tcgccataat cgcgtaccgc cgggtgatca cgccacggcc
    20521 cggcctgttc gtgcaggtca cgggagcgtt ggtagacgga gctgatcggt gtgtctccgc
    20581 acagccgcag ggcctcacgg cccagcgcca tcgcgtggtc gacgtcgggc gtgcgctgct
    20641 gcagcagcgc ggcggcgacg tcgaggcgta ctagcgatcg gctccaggag gaggccgagt
    20701 gctccaccag atcgtcgatg agctcggcgt cgcgcagtac ctgggccgtg ttgcgcagcg
    20761 ccacgtgtga cgtgacggcg ttggccagcg tccgcgcccg cccgtacggc tcgaaggaga
    20821 tgcaggaggt cagcccgacg ggtacctcgt ggaggtcgga gaggcgtagt gcctgtccga
    20881 tggcctgctc gacggcacgc cggtcgccgg tcttgccgag ggcccgggcc cggccgttgg
    20941 cgagcaggcg gatgcactgg gcgtggcgcg gggctcgctc gacggccgcg gccgcgcagg
    21001 cgtccgcctc gtcgtaccgg ccggcgtagt agaggctgaa ggagagggtt ccgcacgccc
    21061 agaggtcggt gtccaggtcg ccgatctcac ggctgagatc ccgggcttcg gtgcagtacg
    21121 ccgccgagag cgcgaagtcg cctgtgttca ccgccatgta gccgagcagg ccggaggcgc
    21181 gggcggcgag gcggaagagc tcccggcgcg tgcgtggggg ctggcggccg tcgaggaggg
    21241 tgtgggcgag ctgccgtacc tggcgggcct gggggcggag gacgtacggc ccgtcctgtt
    21301 cgtaccggct ggcgatgccc tccagcgagg agtcgaggaa ggcgagcatc gcgtcgtcgg
    21361 cgttgctggc cgtgagctgc cgggtccggg tgacgatgtc cagtgggttc tcgtcgtcct
    21421 cccgtggcgg aggcgcactc gtcgcctgct ggcccgtgct cgactcctcg tcgcggtcgt
    21481 gcgcggaatc gccgtcgtac gccgtggaga acagctcgga cacgggtctg cccagcatgt
    21541 gctccagaac tcggcaggcg tcaggacggg gcagagtcag caactccccg ccgtaccagc
    21601 ggtcgaactg gcgtggagag acctggaggg acgccaggcg ggggtctcgg tcgagttccg
    21661 ccagccgggc ggcggcccgc tcgtactggc cagcgaaagc ctcgtgcgtc gtcaggtgcc
    21721 gttgctggag cagctgccgg agcagcgttg tccgtggcat ggcccaccct cctggtgcgg
    21781 cgtgcaggac cgacgcggag gcgcgtgccg gcagcgaggt cgtggcctgc tcgcccatcg
    21841 gtcggctgcg gcgcatgccc gtacgaacgc gcgccgtgac tcctgacagc atgccgacgc
    21901 aaccaccaac taggcaatat gtctggtgaa gttgacccgt atgggttgta gaggtgtcgc
    21961 cggtatggag agacttccgg catggccttg aagagaagcc tggtcccgca gtcggtgtac
    22021 cggcgacagc tcgcggcacg gctgaaggaa ctgcgtgacg cgaccgggct caccctcacc
    22081 gaggttgccg accaactgga agtcaaccag gggtcgctga gccggatcga gaacggcgaa
    22141 cgcggcacga cgccggtcct cgtccgggca ctgctggacc tttacggcgt caaggacgag
    22201 gaccggcgcg ccgacgtgct cgacctcgtg cgagcggaca aggagcagca gaagccctgg
    22261 tggcggaagt attcgacagt gctcacgccg acccgctatg acgggtacct cgcgctggag
    22321 gccggcgcga cgcacctcgc cagctatcag ccgatgctcg tgccggggct gctgcagacc
    22381 gaggactacg cgcgtgccgt gatctcccag atgaggaagg acctgtcccc gccgcaggtc
    22441 gagtccctgg tcagggtccg catggagcgg cagaacagcc gcttgggtgg tgaggccccc
    22501 gccagactct gggcgatcct cgacgaagcc gtgctgcgca ggacggtcgg ctctgttgaa
    22561 gtgatgcgcg accagatgcg gaagctggtg gaggcgagcg agcggtcgaa cgtcaccgtg
    22621 cagctgctgc cgttctcgct cggcgcgcat cccgggctgt acggcccgtt cgtcatcctg
    22681 accttcccgc cccccacgcc ggacctggtg tggctggaga atcccaagaa ctccgtgtat
    22741 ctcgagtccc cagaggacgt ggagaactac acggacatct tcgaccagtt gaggagcacc
    22801 gccctcgacc cgtcggagac ccgcaccctc atcgcgcgca tcagcaagga gctcgaagag
    22861 tgagcacgcc cagcacgtcc gccccgcacg atgtcacgac agctccgcac gacgccgatc
    22921 ttgctcacgc gcggtggcgg aagagctcgt acagcggggg tgcgaacgac tgtgtggaag
    22981 ttgctgcact gggcgaccgc gccgcagtgc gcgattccaa ggacatcagc cgtgggccgt
    23041 tgctcttctc gaaggcggcg atgcgcgcgc tggtcagcgg gatcgcctgc gggtcagtca
    23101 gtgagcgttg gagctgaaaa gagggctgag gcgcgaggac atcccaggca gagctggctc
    23161 cacacggcct tcgcccggcg ggcgctgtcg gcctcgacgc agctgcggag ccaaaggagc
    23221 ccggttcgct tcgagccctc acagttcgcc cgcggtgccc tatgggcggt gaggctgtcg
    23281 gcgaccgcac cctcgaacgc ggcccgcagc gaaggccgcg ccccggtacc ggctcgccgc
    23341 agtggcggtg agcacggtgg gcgaagcgga tacgaccgtg acggggccgg ccatagtggg
    23401 gccgcctacg tccgcgagaa gcaggtcggc ggtgtcgatc tgctggcgga tcgtcggggt
    23461 catggcgtga cctcctccgg cttacgcacc gtctgcgcta cggcctcaat gtcgttcacg
    23521 aaccggtggg gtccggcacc gacgtgcccg acggatggac gccctcctga caccggcgga
    23581 tgaggtccac cgccccaggg ccgcagcgcc tgcgcatctc gcggtaaacg tcacctatcc
    23641 ctccgctcgt agcgtggagt ccgtgatcgc aggggaaact ccagatcaca tcaattgcga
    23701 taactgggca gactccgaca ccgcatgtca gtggcgtgcg cgatgatgta ggccgaccag
    23761 gggatgagag aggtttggcc gctgtggatg tctttgaact gcaccggaag cttgtcgctg
    23821 actaccggca gttcaccgag tcattcgtgg gcatccggga ccccagaatt cgtgaggccg
    23881 tcgagcgcga cctcgcagaa ggcggccaat ggccggacgc atggctgtcg atcaatcctc
    23941 tcttcgaacc ggggggctcg gttgacgcgc tcgtcaaggg ccagctgctg caccccgagt
    24001 gctccaagat cttccgcacc ggcaaagatg ccgaaggggc tcccggcgtt cccatctctt
    24061 tccaccggca ccagcgagaa gcgatcgagg tagctaccac cggcaggagc ttcgtgctca
    24121 ccaccggcac cggttcgggc aagagcctcg gctacatcgt gccaatcgtg gaccacatcc
    24181 tgcgtgcacg cgccgcgggc gatacggaac gccgtacgcg cgcggtgatc gtgtacccga
    24241 tgaacgctct ggcgaacagc cagcgcaagg agctcgagaa gttccttcag gcagggtacg
    24301 ggccagaggc gtcgccagcg acctttgccc gctacaccgg ccaggagtcc gaggaggagc
    24361 gccaccggat cctgcgcgat cgccccgaca tcatcctcac gaactacgtg atgctcgacc
    24421 tcctcctcac ccgcgacaag gagcgcggaa actttctgaa tgccacacgc gatctgcgtt
    24481 tcctcgtcct ggacgagctc cacacctacc gcggccggca gggagcggat gtcgctctgc
    24541 tggtgcggcg tgtgcgggac gcctgcgagg cgcggagcct tcagtgcatc ggcacctctg
    24601 ccaccatgtc gaacgaggga gatcatctgg agcgccgcaa ggacgtggcg cgcgtggcca
    24661 gccggatctt cggagggccg gaagacgttg caccggaaca tgtaatcggc gagacactcc
    24721 gccgcgccac ccgagggccg gatccgtcac cggcgcagct gaccgaagcc gttctcaggg
    24781 caccggaccg gctcacccgc gactacgacg atcttgctga ggatccgctc gcgatctgga
    24841 tcgagaacac cttcggtctg cgggaccagg ccgggcatct ggagcggcag cgcccgatca
    24901 cgctggctga tgctgcggtc ggcctggccg ccctggtgaa cctggacgag gacacgtgca
    24961 gggctgccat cgaggacatg ctgcgtgccg gagcgaaggc gaaggcccct gacacgcatc
    25021 gccccttgtt cgccttccgt ctgcaccagt tcgtgtcgaa gggggacacc gtctatgtaa
    25081 gccttgagcc cgaggcgaca cgctacgcca ccaggcgata ccagcgtgtg gtccaaggtg
    25141 accggggcaa gctcctgctg cccttgtcct tctgccgcga gtgcggccag gagtacctcg
    25201 ctgtgtcccg gacgatgaga gccggccagg tggcctacga gccgaggcac gaccacgagt
    25261 cggacgacga tcagaccgcg gacggctatc tgtatgtgag caccgccgca ccgtggccag
    25321 cggatcctgt cacggacggg cggctgccgg actcctggct cgtgcgcgac gaatccggta
    25381 tccatgtgac cgacaatcgt cggcgctatc ttccggtgcc tgtgaccgtg gccctcgacg
    25441 gtacggaaat ggggtacggc ggcgcagaga gcgagtcctc agccgcgggc gaccacggca
    25501 ctgaacctcc cgaggggctt agggctgcct tcgtccccgc cccgttcctg ttctgcctga
    25561 accccgagtg caaggtctcg tacgagcagg tccgtggccg ggacttcgcc aagctcgcca
    25621 gcctcgactc ggaggggcgc agctccgcga tgacggtgat cagcgcgagc atcgtccgga
    25681 gtctgcgcag ccagccaccc ggcgaggaga tgccgagaga ggctcagaag cttctcacct
    25741 tcgtggacaa ccgtcaggac gccagtctgc aggctgggca tttcaacgac tttgtccagg
    25801 tgacgcatct gcggggcgcc ctggtcaagg cgttgagtga cgccggtcca gccgggttgc
    25861 gctacgacac tctggcgcag cgtgtcaccg atgccctggc cctgccggtg gagtcctacg
    25921 cgggcagggc ggaggttcgc ttcagccatc agcgggagaa tgtcacctct gctctgcgcg
    25981 cggtggtgga actcctcctg taccaggacc tgcaggggtc ctggcgtgtg acgatgccgg
    26041 gcctggagca gaccgggctg ctggttttcg actatccggc tctcggtgag atcgccgctg
    26101 ccgaggacct ttgggagacc gggcacgcgg ctctcgccga cgccgccccg gagcagcgcg
    26161 agcagctgct ccggctggtg ctcgatgaga tgcgccgcaa tctcgccgtc gacgtcgagg
    26221 ttctgtcccg caccggtttc gagcgggtgc gttcgcgctc cgaccagtgg ctgactggcc
    26281 cttgggcgct ctcggagagt catccggagc cccgccctgc ggctgtgttc ccaacgccgg
    26341 cgcggcccgg cgggtaccgc agtgacgtcc acttcaccgg ccggtccatg ctcggccgct
    26401 atctgcgcgc gccgagctgt ttccctcacc tgtcggaccg cctgaccgtc gacgacgccc
    26461 agctcgtgat ccgcaggctg ctcgaagcgc tctgcgaagc agacctgatc acggagtccg
    26521 tgccacggtc ggagacgggt acccccggct acagagtgaa ggcgtcctcg ctgctctggc
    26581 tgccttcaga cggttccgaa ggcatgcgcg atctgctgcg tcgccgacac ggtgccaccg
    26641 cgccgcgcgt taatgccttc ttccgtggtc tctacgcgga tctcgcgcac agcctcgccg
    26701 ggctgcaagc cgcggagcac accgctcagg tccccacgcc cgtacgggag gaacgggagg
    26761 ctcggttcag ttctggccag ctgccgttgc tgtactgctc cccgacgatg gagctcggcg
    26821 tcgacatcaa gagcctcaac accgtcgcga tgcgtaatgt gccgcctacc ccggcgaatt
    26881 acgcgcagcg ttccgggcgc gctggacgtt ccggtgagcc cgccctggtc accacctact
    26941 gtgccaccgg gaacgcacac gatcagtact acttccgtcg gtcccacctc atggttcaag
    27001 ggcgggtggc gccgccacgc ctcgatctcg cgaacgaaga tctggtccgc agccacatcc
    27061 aggcgatctg gctcgccgag accggagccg acctgcactc gagcctgccc gaggtactgg
    27121 atctcgctga ttcgatgcgc ggttatccag tgcgcgagga gatctgggcg cagatgctcg
    27181 atcctgcgcc gggccgccgt gcggaggagc gggcccggaa cgtgctcgcg tccgtaccgg
    27241 acctcgacag ctcaagctgg tggagcccgc gctggctgga ggacgttgtc cgcaacgccg
    27301 cgcgaggctt cgaccgagcc tgcgaccgct ggcgcaacct ctaccggggc gctctcgcgg
    27361 agcaggagga acagaaccgc cgtgtcctcg accagtcgct gagcccccag tcccgtgagc
    27421 aggcggcccg gcgcaggcgc gaagccgaga accagctcaa gttgctgcgg aacgaggaca
    27481 gccagcgcct cggccacaac ttcagcgact tctacacgta ccgctacttc gcgtctgagg
    27541 ggttcctgcc cggatactcc ttcccacggc tcccgctggc tgcgtacatc ccgggctccc
    27601 gcaaagctcg gggtgcgggt gctgagggcg actacttgca acgcccccgt ttcctggcca
    27661 tcaacgagtt cggccccggt gccctcatct accacgaagg agcccgatac gaggtcaagc
    27721 gggtgcagtt gcccatcgcc gaaccgggcg agatcgacac cgaagcggcc cggctctgcc
    27781 gccactgcgg ctacttccac gagcagcagg ccgggacgga tctctgcgac aactgcgggg
    27841 aagcgctcac cgggctcatc cccaacctga tgcggttgac cacggtcgtc accgagcgtc
    27901 gcgaacgcat ctcctccgac gaggaagaac gacgccgggc aggcttcgag ctgg
//
