LOCUS       NZ_CM002285            21086 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3146873
            Orig. end                         :: 3167959
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="22"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11086)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    117..132
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: strong, score: 24.62"
                     /tool="antismash"
     gene            173..958
                     /gene="nagB"
                     /locus_tag="M878_RS63290"
                     /old_locus_tag="M878_14375"
     CDS             173..958
                     /EC_number="3.5.99.6"
                     /GO_function="GO:0004342 - glucosamine-6-phosphate
                     deaminase activity [Evidence IEA]"
                     /GO_process="GO:0006046 - N-acetylglucosamine catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="nagB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984448.1"
                     /locus_tag="M878_RS63290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14375"
                     /product="glucosamine-6-phosphate deaminase"
                     /protein_id="WP_023546867.1"
                     /transl_table=11
                     /translation="MEVVIVPDAAAGGELIAEAMAQLLRRKPDAVLGVATGSTPLPIYQ
                     ALTAKVRSGAVDTSRARVAQLDEYVGLPADHPESYRSVLRREVLEPLGIGMDSFLGPDG
                     TAEDIQAACEAYDRALAEAGGVDLQLLGIGTDGHIGFNEPCSSLASRTRIKTLTEQTRV
                     DNARFFDGDIDQVPHHVITQGIGTILEARHLVLLATGEGKADAVAATVEGPVAAVCPAS
                     ALQLHRHATVVADEAAASKLKLADYFRHTYANKPEWQGI"
     misc_feature    complement(1265..1280)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.27"
                     /tool="antismash"
     gene            1416..2180
                     /locus_tag="M878_RS63295"
                     /old_locus_tag="M878_14380"
     CDS             1416..2180
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="M878_RS63295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14380"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_023546868.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEAGTTVRTARVPKYYRLKKHLLDMTETQAPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDISAGGRVLRIERLRMANGEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRH
                     SLDREGKPVEWVRSVYRGDRYKFVARLKRPAE"
     misc_feature    2245..2259
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.35"
                     /tool="antismash"
     gene            2332..2595
                     /locus_tag="M878_RS63300"
                     /old_locus_tag="M878_14385"
     CDS             2332..2595
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010984454.1"
                     /locus_tag="M878_RS63300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14385"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_031224888.1"
                     /transl_table=11
                     /translation="MSETPEVRPPVVTPVRVIIALCLVAPFVAMLWVGSYAETDPAFIG
                     IPFFYWYQMLWVLVSTALTMTAYKLWQRDQRARAAQKGGAAQ"
     gene            2592..4211
                     /locus_tag="M878_RS63305"
                     /old_locus_tag="M878_14390"
     CDS             2592..4211
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437916.1"
                     /locus_tag="M878_RS63305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14390"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_023546870.1"
                     /transl_table=11
                     /translation="MKNGVNGVALGVFIFFFLAVTVMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHKHGYVTTSDFVRGRFGSKGLSLAVALTGILATMPYIALQLVGIQAVLDVMGVGGD
                     SSSNWFVRDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVITVAIIYIPIKLGG
                     FDDIFAKAGHAFSQVNPATGKPRGALAPPEAGQWTYATLALGSALALFMYPHSITATLS
                     SKSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVTNGQLAIPQLFEDMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPKQEAQVSKIVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMAYGTVAAY
                     GVASPTQKHFGGSAKQIPGIGEIGYIGLTAFVLNVAVAVVLTIVLKAVKAPEGVDETEP
                     EDYTADAGEPGVQTELTPTATP"
     gene            4335..4838
                     /locus_tag="M878_RS63310"
                     /old_locus_tag="M878_14395"
     CDS             4335..4838
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992857.1"
                     /locus_tag="M878_RS63310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14395"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_031224890.1"
                     /transl_table=11
                     /translation="MDIQIRPADPADYDALGDITAQAYLQDGLLDFGESDTYLGELRDV
                     AKRAAAAEVLVAVRDGVLGGVTFVPFPGPMTDIARPGEAEIRMLAVAGAARGQGAGEAL
                     VQACLDRARATEGCRAVVLSTQRTMRAAHRIYERLGFVRTPERDWNPLPEQLDITLLTY
                     QLTL"
     misc_feature    4849..4863
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     regulatory      4878..5016
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    4880..4894
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.4"
                     /tool="antismash"
     gene            5141..7525
                     /locus_tag="M878_RS63315"
                     /old_locus_tag="M878_14400"
     CDS             5141..7525
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="M878_RS63315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14400"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_023546872.1"
                     /transl_table=11
                     /translation="MTIAPADPASVGEVSEPETDGPGTALLRTLTELTADLPDADPGRV
                     AAAALRGRSARAGEAELRELATEAAAGLISEDPAYSRLAARLLTLSIRAEAASQGVTSF
                     TESVAVGHREGLIADRTAEFARLHAERLDALVDRAADDRFGYFGLRTLHSRYLLRHPLT
                     RKVIETPQHFMLRVAAGLAEDDTVRSVDEVAALYRLMSRLDYLPSSPTLFNSGTRHPQM
                     SSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVP
                     FLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWI
                     PDEFMRRVNADAQWSLFSPADVPELVDLWGEEFDAAYRKAEEKGLAKKTIPARELYGRM
                     MRTLAQTGNGWMTFKDAANRTANQTALPGHVVHSSNLCTEILEVTDDGETAVCNLGSVN
                     LGAFVDLSTGDLDWQRLDETVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGL
                     QDVFFKLRLPFDSPEARALSTRIAERIMLAAYEASTDLAERSGPLPAWEKTRTAQGVLH
                     PDHYGVELTWPERWEALRRRIAETGLRNSLLLAIAPTATIASIAGVYECIEPQVSNLFK
                     RETLSGEFLQVNSYLVQDLKNLGVWDARTREALRDSSGSVQDFVWIPEDVRALYRTAWE
                     IPQRGLIDMAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPAT
                     RIARAAQAQAQTPVPIPVQQVADPDAIACSLENPESCEACQ"
     gene            7525..8550
                     /locus_tag="M878_RS63320"
                     /old_locus_tag="M878_14405"
     CDS             7525..8550
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009307556.1"
                     /locus_tag="M878_RS63320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14405"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_023546873.1"
                     /transl_table=11
                     /translation="MTTPTTTRNTNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEE
                     VDLHSDVADLAKLTPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQ
                     LFEEAVHVQFYLTLLDTYLPHPEDRAAAFAAVENIPSIREKAEFCFKWIDSVEQIDRLE
                     TKADRRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMS
                     FAFDVVDTVRKEEPDLFDDELRQQVIDMLKEAVEAELQFARDLCGDGLPGMNTESMRQY
                     LECVADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDED
                     F"
     gene            complement(8634..10004)
                     /locus_tag="M878_RS63325"
                     /old_locus_tag="M878_14410"
     CDS             complement(8634..10004)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058302.1"
                     /locus_tag="M878_RS63325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14410"
                     /product="cytochrome P450"
                     /protein_id="WP_023546874.1"
                     /sec_met_domain="p450 (E-value: 7.9e-68, bitscore: 228.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESAQPLTPETSELREPPLAGGAVPGLGHGLKLVRDPLAFMSR
                     LREHGDVVRLKLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGKEGVATANG
                     PRHRRQRRTIQPAFRLDAIPDYGPIMQEEAHALTERWRPGETIDCTSESFRVAVRIAAR
                     CLLRGDYMDERAERLSVDLASVFRGMYRRMVVPLGPLYRLPFPANREFNRALADLHLLV
                     DEIVAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETVASTIMWL
                     LQVLAEHPEHAEKVRTEVESVTGGRPVGFEHVRTLTHTNNVVVEAMRLRPAVWILTRRA
                     VTDTELGGYRIPAGADIVYSPYAIQRDAHSYDRHLDFDPDRWLPERAKDVPKYAMSPFS
                     VGNRKCPSDHFSMTQLSLITAAISAKYRFEQVSGSNDTTRVGITLRPHDLRLRAMPW"
     gene            complement(10001..11086)
                     /gene="cyc1"
                     /locus_tag="M878_RS63330"
                     /old_locus_tag="M878_14415"
     CDS             complement(10001..11086)
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="M878_RS63330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14415"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_031224891.1"
                     /sec_met_domain="T1TS (E-value: 8.4e-64, bitscore: 215.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAFPHSTTATPTAVVVPPSLVLPVIESAFPRQLHPYWPRLQQMT
                     RRWLLEKRFMPADKVHEYADGLCYTDLMAGYYLGAPEEVLQAIADYSAWFFVWDDRHDR
                     DRVHGRVGAWRRLRYRLHAALDAPRHHLHHPDPLVAGFADSVLRLYGFLPRTWNQRFAR
                     HFHAVVEAYDREFRNRTTGYIPGVEEYLALRRHTFAHWIWTDLLEPSAGCELPNAIRKN
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHEGLSLEEAVDEVRRRVE
                     ECISEFLEAEQVALRFADQLADGTVRGKELSTAVRACVGNMRNWFSSVYWFHHESGRYM
                     VDTWDDRSTPPYVTNEAAGEK"
     misc_feature    complement(11284..11296)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.85"
                     /tool="antismash"
     gene            complement(11388..12038)
                     /gene="def"
                     /locus_tag="M878_RS63335"
                     /old_locus_tag="M878_14420"
     CDS             complement(11388..12038)
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="M878_RS63335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14420"
                     /product="peptide deformylase"
                     /protein_id="WP_023546876.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVVDTEDCEEREKAWRERGTSRPIT
                     VVGNPVLHKECKDVTEFGEELGQLAADMFASQRTAEGVGLAANQIGVDLKVFVYDCMDD
                     EGARHVGVVCNPKLVDLPADKRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEQGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMGENEPRYPVVAND"
     gene            complement(12165..13145)
                     /locus_tag="M878_RS63340"
                     /old_locus_tag="M878_14425"
     CDS             complement(12165..13145)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="M878_RS63340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14425"
                     /product="hypothetical protein"
                     /protein_id="WP_023546877.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWLSESWFNLALLHKFRHDWEQARAAGLRAVALLDREAGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGATVATEPVGMELGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSTGHAYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            complement(13246..14538)
                     /locus_tag="M878_RS63345"
                     /old_locus_tag="M878_14430"
     CDS             complement(13246..14538)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674893.1"
                     /locus_tag="M878_RS63345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14430"
                     /product="HD domain-containing protein"
                     /protein_id="WP_023546878.1"
                     /transl_table=11
                     /translation="MTALRIVHGAAALTAAGSLAVTLWTGLDDRGVALAFGVLIAVGEL
                     TRWSGAQVRQAAPLGTAGSLSYALLGADAGRPTQAGPAQVVTVVLAAALLGAVPHIWSG
                     RTPTLDPLARRVLTVGFTAVCFQPLYNKGLFAAWNGPAYALLLVTLLGLTALCDAVLAA
                     ALARSRTRWPFGPLLREELRGLLGIGSAVCATGAVMALAVAVVGLWALPVFCLPLLLTQ
                     LSVRRYAAVRATYRQTIASLARATEIAGCAPAGHARRVAALSLAVGRDLGLTEGELTVL
                     EYAALMHDIGQLSLLDPVPAGATAELPPEEQRRIALLGGAVVRQTGVAAAVAVMVERQA
                     DPYREQPLAARIIRAVNAYEEKSRDAGPEGPLRALEELRLGTAGDYAPEVVESLARVLA
                     RPRAWPQRAPVDDDGRGTALSDPARRWVTHG"
     CDS             complement(14535..>15501)
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=3
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019072151.1"
                     /locus_tag="M878_RS63350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14435"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_031224892.1"
                     /transl_table=11
                     /translation="ARVHWALGGRNAVVDCHFPYALLPVGAAVLAFCLILTVLDGGIRA
                     VALGVPLRRAWRGLLSRSLAPVAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWIF
                     AQYHRERAAHQATIRALVQAVDIKDGYTRGHSERVGQASVMIARELGMDDERVEVLRFA
                     GILHDVGKLGVPTRLLRKDGPLTPEERRIIELHPEYGHEMVRGISFLGEARAAILHHHE
                     RLDGTGYPYGLVGTQIPECARVVAVADAFDAMTSTRSYRRARPVEAAVAELGRCAGTQF
                     DPRMVGALARALGRYGWHPTVTADETPYELRGRKPVSGAPR"
     gene            complement(14535..>15505)
                     /locus_tag="M878_RS63350"
                     /old_locus_tag="M878_14435"
     assembly_gap    15506..16598
                     /estimated_length=1093
                     /gap_type="within scaffold"
                     /linkage_evidence="unspecified"
     gene            complement(<16599..16828)
                     /locus_tag="M878_RS47800"
                     /pseudo=""
     CDS             complement(<16599..16828)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973754.1"
                     /locus_tag="M878_RS47800"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="metal-dependent phosphohydrolase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEADSARARGFVAVVALLALFCLLPLPTIRTPWWALSLLSALYAG
                     CEHVVRRRFGGTFYPVLLAGAFLLPPPAAAL"
     misc_feature    complement(16923..16938)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(16946..17248)
                     /gene="rsrA"
                     /locus_tag="M878_RS63355"
                     /old_locus_tag="M878_14445"
     CDS             complement(16946..17248)
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645393.1"
                     /locus_tag="M878_RS63355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14445"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_023546880.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDIDRDKFRHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPADLRAKVMGRIDLIRSGQAVPEHDITATPQDG"
     gene            complement(17245..17940)
                     /gene="sigR"
                     /locus_tag="M878_RS63360"
                     /old_locus_tag="M878_14450"
     CDS             complement(17245..17940)
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="M878_RS63360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14450"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_023546881.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAEQPEGQGVSAEAAAESTAERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARDRGLVPAGAGE
                     SNEAKGSGS"
     gene            complement(18251..18877)
                     /locus_tag="M878_RS63365"
                     /old_locus_tag="M878_14455"
     CDS             complement(18251..18877)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="M878_RS63365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14455"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_023546882.1"
                     /transl_table=11
                     /translation="MIEIVETDAGTARITWHRAEDPGLVLALSHGAGGGVEARDLQALA
                     HALPAHGVTVALVEQPWRVAGKKVAPAPKTLDAGWRDIWPALAGMELPVVSGGRSAGAR
                     VACRTAAGLGAHAVLALSFPLHPPGKPEKSRAAELLGAGVPTLVVQGGNDPFGKPEEFP
                     KGSYELVEVAYGDHGFAVPKRAGITQERALEIITESVAEWLASLG"
     gene            complement(18879..19694)
                     /locus_tag="M878_RS63370"
                     /old_locus_tag="M878_14460"
     CDS             complement(18879..19694)
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="M878_RS63370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14460"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_031224894.1"
                     /transl_table=11
                     /translation="MCGRYASSRRPEDLAGVFEIEKWEPEETLEPDYNVAPTKEVYAVL
                     DRPLKDADSPRPVRQLRKLKWGLVPSWAKTPEGGARMINARAETVHEKPSYRRAFAARR
                     CILPADGYYEWVTGKDERELEAEGKKKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPRAWWATCSVITTEAERTPLAVAPAEGPHALADIHPRMPLMLTPDRWDAWLDPGRT
                     DPDDLRELLAPPPPGLMRAYPVSTAVSNVRNNGPELLKELAAPEEGTLF"
     misc_feature    19728..19742
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
     gene            19744..20466
                     /locus_tag="M878_RS63375"
                     /old_locus_tag="M878_14465"
     CDS             19744..20466
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992842.1"
                     /locus_tag="M878_RS63375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_14465"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_023546884.1"
                     /transl_table=11
                     /translation="MDSLAATSLTGLWDRLTGTQPDPALWVVLATLAAALAVIVPHGPW
                     RISRNAITIAHEGGHGLIALLTGRQLTGIRLHSDTSGLTVSRGKPHGLGMILTAAAGYT
                     APSLLGLGGAALLATGRITLLLWVATALLVVMLVMIRNAYGVLTVVLTGGAFLLVSWLA
                     GPQVQAAFAYAVVWFLLFGGVRPPFELQLKRSRGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVTLSSLIGGGRWLLEL"
ORIGIN
        1 gggtgacggg ccattggctg gacgcgacgg gaggctccct cacctgaggc tttccctgag
       61 gctttccctg accttcgccg tccctttcct gggccgtcga acgccacttc tgttagattg
      121 gtctaaacca catagagacg cacagagccc acttcagaac ggcaggccca gcgtggaagt
      181 tgtcatcgtt ccggacgccg cggcgggcgg cgagctgatc gccgaggcca tggcccagct
      241 gctgcgacgc aagcccgacg ccgtgctcgg cgtggccacc ggctcgaccc cgctgcccat
      301 ctaccaggcg ctgaccgcga aggtgcgctc cggcgccgtc gacacctcgc gggcccgcgt
      361 agcccagctc gacgagtatg tgggactgcc cgccgaccac cccgagtcct accgctcggt
      421 gctgcgccgc gaggtgctgg agccgctcgg catcggcatg gactccttcc tcggccccga
      481 cggcaccgcc gaggacatcc aggcggcgtg cgaggcgtac gaccgtgcgc tcgccgaggc
      541 cggcggggtg gacctccagc tgctcggcat cggcacggac ggacacatcg gcttcaacga
      601 accctgctcg tccctcgcct cgcgcacccg gatcaagacg ctgaccgagc agacccgcgt
      661 cgacaacgcc cgcttcttcg acggtgacat cgaccaggtg ccgcaccacg tcatcaccca
      721 gggcatcggc accatcctgg aggctcggca cctggtgctg ctggcgacgg gcgagggcaa
      781 ggcggacgcg gtcgccgcga ccgtcgaggg gccggtcgca gccgtctgcc cggcctccgc
      841 actccagctg caccgccacg ccacggtggt cgccgacgag gcagccgcgt ccaaactgaa
      901 gctggcggac tacttcaggc acacctacgc caacaagccg gagtggcaag ggatctaggc
      961 cggatcgacg cggggccagc ggggagccgg ccagggggtg ggcaaggggt tccggtcggg
     1021 agcggcaggg ggccgggagc cgatccagcg ggaggggggc cgggggtcag gagccgatcc
     1081 agcgggatcg gccgggggcc gggggcggat ccagcgggat cggccggagt cggccggggt
     1141 ctggcagtag atccagcggg gtcggccggg gattcagccg cggtcggcac gggtctggca
     1201 gcgaagccgg caggggggcg cggcgggctc ttcccgctcg cccgggcgtg ctcaccgggc
     1261 gcccgatgga ctagaccagg agcgggtgcg acggtatata gaggggatca cggagggtgt
     1321 gggtggactc cagacccccg aagccgtgcc acgatgtgag ccgtggccga tgccaggtcg
     1381 gtcgatttcg gcatccggag ccgggaaggc agagcatgag caccgacgtc agcagtgcgg
     1441 agaacgaggc tgggacgacc gtccgtacgg cgcgcgtgcc caagtactac cgcctgaaga
     1501 agcacctgct cgacatgacg gagacgcagg ctccgggcac gccggtgccg cccgagcgca
     1561 cgctggccgc cgagttcgac acctcccgca ccaccgtccg ccaggccctg caggaactgg
     1621 tcgtggaggg ccggctcgag cgcattcagg gcaagggcac gttcgtcgcc aagcccaagg
     1681 tctcccaggc gctccagctc acctcctaca ccgaggacat gcgcgcccag ggtctggagc
     1741 cgacctcgca gctgctggac atcggctaca tcacggccga cgaccggctc gccgggctgc
     1801 tcgacatcag cgccggcgga cgcgtgctgc gcatcgagcg gctgcgcatg gccaacggtg
     1861 agccgatggc catcgagacc acgcatctga gcgccaagcg cttcccggcc ctgcgccgct
     1921 ccctggtgaa gtacacatcc ctctacaccg ccctcgccga ggtctacgac gtccacctcg
     1981 ccgaggccga ggagaccatc gagacctcgc tggccacccc gcgcgaggcg ggcctgctcg
     2041 gtaccgacgt gggcctgccg atgctgatgc tctcccgtca ctccctggac cgcgagggca
     2101 agccggtgga gtgggtgcgg tccgtgtacc ggggggaccg ctacaagttc gtggcacgcc
     2161 tcaagcggcc ggcggagtag ggcccgtcaa cgcccctgcg gagcacggcc ggtggacgtt
     2221 cgctgaatcg atataccgat atgcggacga ggtcttccac tgccacgaca ccgtcaccta
     2281 gattgcctgc gcattacaca ggtgatcagc gaggggacgg agagccgtgg catgtccgaa
     2341 acacctgaag tgagaccacc ggtcgtcaca ccggtccggg tgatcatcgc cctgtgtctg
     2401 gtcgcgccct tcgtagcgat gctctgggtc ggttcctacg ccgagacgga ccccgcgttc
     2461 atcgggatcc cgttcttcta ctggtaccag atgctctggg tgctggtctc caccgcgctc
     2521 accatgaccg cgtacaagct gtggcagcgc gaccagcgcg cccgggcggc ccagaagggc
     2581 ggtgcggcgc agtgaagaac ggcgtcaacg gcgtcgcgct cggcgtcttc atcttcttct
     2641 tcctggccgt cacggtcatg ggcttcctcg ccgcgcgctg gcgcagggcc gagaacgagc
     2701 actccctgga cgaatggggc ctgggaggac ggtcgttcgg cacctggatc acctggttcc
     2761 tgctcggcgg cgacctgtac acggcgtaca ccttcgtcgc cgtaccggcg gcgatctacg
     2821 cggcgggcgc gtccggcttc ttcgcggtgc cgtacacgat cctggtctac ccgctgatct
     2881 tcaccttcct gccgcgcctg tggtcggtgt cccacaagca cggctatgtg acgacctcgg
     2941 acttcgtgcg cggccgcttc ggctccaagg gcctgtcgct ggcggtcgca ctgaccggca
     3001 tcctggcgac gatgccgtac atcgcgctcc agctcgtcgg catccaggcg gtgctggacg
     3061 tgatgggcgt cggcggggac agcagcagca actggttcgt acgcgacctg cccctgctca
     3121 tcgccttcgg cgtgctggcg gcgtacacct actcctccgg actgcgcgcc cccgcgctga
     3181 tcgcgttcgt caaggacacg ctgatctaca tcgtcatcac ggtggcgatc atctacatcc
     3241 cgatcaagct gggcggcttc gacgacatct tcgccaaggc cggccatgcg ttcagccagg
     3301 tcaacccggc gacgggcaag ccacgcggcg cgctcgcgcc cccggaggcg ggccagtgga
     3361 cctacgccac cctggccctc ggctcggccc tggccctgtt catgtacccg cactcgatca
     3421 ccgcgaccct ctcctccaag agccgtgagg tgatccgccg caacaccacc atcctgccgc
     3481 tgtactccct gatgctcggc ctgctggccc tgctgggctt catggcgatc gcggccgggg
     3541 tcaaggtcac caacggccag ctggcgatcc cgcagctgtt cgaggacatg ttcccggact
     3601 ggttcgcggg cgtggcgttc gcggcgatcg gcatcggcgc gctggtaccg gcggcgatca
     3661 tgtccatcgc ggcggcgaac ctcttcaccc gcaacatcta caaggacttc atcaaaccgg
     3721 acgccacacc gaagcaggag gcccaggtct ccaagatcgt ctcgctgctg gtgaaggtcg
     3781 gcgcgctggt cttcgtcctc accatggaca agaccgtcgc catcaacttc cagctgctgg
     3841 gcggtatctg gatcctgcag accttcccgg ccctggtcgg cggcctgttc acccgctggt
     3901 tccaccgctg ggccctgctc gccggctggg cggtcggcat ggcctacgga acggtcgccg
     3961 cgtacggcgt cgcctccccg acccagaagc acttcggcgg ttcggcgaag cagatccccg
     4021 gcatcggcga gatcggctac atcggcctca cggccttcgt cctcaacgtc gccgtggccg
     4081 tggtcctcac catcgtcctc aaggccgtga aggcccctga gggcgtcgac gagaccgagc
     4141 cggaggacta cacggcggac gcgggagaac ccggcgtgca gacggaactg acgcccaccg
     4201 caaccccata agggaggcgc ggggccgtat cgacatgcgg ctccgccgcg tgggcgcgag
     4261 tgaccacgga caacccgcag cgggccgccg gaaagcaagt gctacggcgg cccgctcgct
     4321 tgcacactca caccatggac atccagatcc gccccgcaga ccccgccgat tacgacgcac
     4381 tcggcgacat cacagcccag gcctacctcc aggacggcct cctggacttc ggcgagagcg
     4441 acacatacct cggtgaactc cgggacgtgg ccaaaagagc cgccgccgca gaggtcctgg
     4501 tggccgtacg cgacggagtg ctcggcggcg tcaccttcgt ccccttcccc ggccccatga
     4561 ccgacatcgc gcgccctgga gaggcggaga tccgtatgct ggccgtggcc ggcgccgccc
     4621 gtggtcaggg agccggcgag gccctcgtac aggcgtgcct cgaccgcgca cgggccaccg
     4681 agggctgtcg ggccgtcgtt ctgtcgaccc agcgcaccat gcgcgccgcc caccggatct
     4741 acgaacgcct cggcttcgtt cgcacacccg agcgggactg gaatccgctg cccgagcagc
     4801 tcgacatcac tctgctcacc tatcagttga cgctctgaga ccaccgcgac acaacatctg
     4861 ggggtgccac gacagcccgg cactagatgt atgctcgtcc tcgctgtcgc cgcaggggaa
     4921 tccggtgcga atccggaact gtcccgcaac ggtgtacttg cgtgcattcg cacgctcgcg
     4981 tcagtccgag gacctgccgg cagcgcaccc ggccgtccgg tccgggtgcc ctgagacgtc
     5041 cgggcctcgt ggaatgggcc ggtggacgcg acgccgtgtg cgctcgtggc tgcctcctgc
     5101 cctccacaag gcccccgtgc cgagcgaggg agagccccac gtgaccatcg cgccagcaga
     5161 tccggcttca gtcggcgaag tcagcgagcc ggagacggac ggtcccggta ccgcgctgct
     5221 gcggaccctg accgagctga ccgccgacct ccccgacgcc gaccccggcc gggtcgccgc
     5281 cgccgcgctg cgcggccggt ccgcccgcgc cggcgaagcg gagttgcgcg aactggccac
     5341 cgaggccgcc gccgggctca tctccgagga ccccgcctac tccaggctgg ccgcccggct
     5401 gctgaccctc tccatccgcg ccgaggccgc ctcgcagggc gtgacgtcct tcaccgagtc
     5461 cgtcgccgtc ggccaccgcg agggcctgat cgccgaccgc accgcggagt tcgcgcggct
     5521 gcatgccgaa cgcctcgacg ccctggtcga ccgggcggcc gacgaccgct tcggctactt
     5581 cggtctgcgc accctgcaca gccgctatct cctgcggcac cccctcaccc gcaaggtcat
     5641 cgagacgccc cagcacttca tgctccgggt cgccgccggt ctcgccgagg acgacaccgt
     5701 ccgctccgtc gacgaagtcg ccgcgctcta ccggctcatg agccgcctcg actacctccc
     5761 gtcctccccc acgctcttca actccggcac gcggcacccg cagatgtcgt cctgctatct
     5821 cctcgactcc ccgctggacg agctggactc catctacgac cgctaccacc aggtggcccg
     5881 gctctcgaaa cacgccggcg gcatcggtct gtcgtactcc cggatccgca gccgcggttc
     5941 gctgatccgc ggcaccaacg ggcactccaa cggcatcgtc cccttcctga agaccctgga
     6001 cgcctcggtg gccgcggtga accagggcgg ccggcgcaag ggcgccgcgg ccgtctacct
     6061 ggagacctgg cactcggaca tcgaagagtt cctggagctg cgggacaaca ccggtgagga
     6121 cgcgcgccgt acgcacaacc tgaacctcgc gcactggatc ccggacgagt tcatgcgccg
     6181 ggtcaacgcc gacgcgcagt ggtccctctt ctcccccgcc gacgtgccgg agctggtgga
     6241 cctgtggggc gaggagttcg acgccgccta ccgcaaggcg gaagaaaaag gcctcgcgaa
     6301 gaagacgatc ccggcccgtg agctgtacgg ccggatgatg cgcaccctcg cgcagaccgg
     6361 caacggctgg atgaccttca aggacgccgc caaccgcacc gccaaccaga cggccctgcc
     6421 gggtcacgtc gtccactcct ccaacctctg cacggagatc ctggaggtca cggacgacgg
     6481 cgagacggcg gtctgcaacc tggggtccgt caatctgggc gcctttgtcg atctgtcgac
     6541 cggcgacctc gactggcagc ggctggacga gacggtccgt acggccgtca ccttcctcga
     6601 ccgcgtcgtc gacatcaact tctatccgac cgagcaggcg ggtcggtcga acgccaagtg
     6661 gcgtcccgtc ggtctcggcg cgatggggct gcaggacgtc ttcttcaagc tgcgcctgcc
     6721 cttcgactca ccggaggcca gggccctgtc cacgcggatc gccgagcgga tcatgctcgc
     6781 cgcgtacgag gcctccaccg acctcgccga gcgcagtggc ccgctgccgg cctgggagaa
     6841 gacccgtacg gcccaggggg tgctgcaccc cgaccactac ggcgtcgagc tgacctggcc
     6901 cgagcgctgg gaggcgctgc gccggcgtat cgccgaaaca gggttgcgca actcgctgct
     6961 gctcgccatc gccccgacgg cgaccatcgc ctccatcgcg ggcgtgtacg agtgcatcga
     7021 gcctcaggtg tcgaacctgt tcaagcgcga gacgctgtcc ggtgagttcc tccaggtcaa
     7081 ctcctacctg gtgcaggacc tgaagaacct cggcgtgtgg gacgcgcgca cccgcgaggc
     7141 gctgcgcgac tcgagcggct cggtgcagga cttcgtctgg atccccgagg acgtgcgcgc
     7201 gctgtaccgc acggcctggg agatcccgca gcgaggcctg atcgacatgg ccgcggcccg
     7261 cacccctttc ctggaccagg cgcagtcctt gaacctgttc ctggagacgc cgaccatcgg
     7321 caagctctcc tcgatgtacg cgtacgcctg gaagtcgggc ctgaagacga cgtactacct
     7381 gcgctcgcgt ccggcgaccc ggatcgcccg cgccgcccag gcgcaggcgc agacccccgt
     7441 ccccatcccc gtccagcagg tcgccgaccc cgacgcgatc gcctgctccc tggaaaaccc
     7501 cgagtcctgc gaggcctgcc agtaatgacc accccgacca ccacccgtaa caccaacctg
     7561 ctggacccgg gcttcgaact gactctccgc ccgatgcgct acccggactt ctacgagcgc
     7621 taccgggacg cgatcaagaa cacctggacc gtggaggagg tcgacctcca ctcggacgtc
     7681 gccgacctcg cgaagctgac gccggaggag cagcacctca tcggccggct ggtggccttc
     7741 ttcgcgaccg gcgactcgat cgtcgcgaac aacctggtcc tgacgctgta caagcacatc
     7801 aactcccctg aggcgcggct gtacctcagc cgtcagctct tcgaggaggc cgtgcacgtc
     7861 cagttctatc tgacgctgct ggacacctat ctgccccatc cggaggaccg ggcggcggcc
     7921 ttcgcagccg tcgagaacat cccctcgatc cgcgagaagg ccgagttctg cttcaagtgg
     7981 atcgactcgg tggagcagat cgaccggctg gagacgaagg ccgaccgccg tcgcttcctg
     8041 ctcaacctga tctgcttcgc cgcgtgcatc gagggcctgt tcttctacgg cgcgttcgcg
     8101 tacgtctact ggttccgcag ccggggtctg ctgcacggcc tcgccaccgg caccaactgg
     8161 gtgttccgtg acgagacgat gcacatgtcc ttcgccttcg acgtggtcga caccgtccgc
     8221 aaggaggagc cggacctctt cgacgacgag ctccggcagc aggtcatcga catgctgaag
     8281 gaggccgtcg aggccgagct gcagttcgcc cgcgacctgt gcggcgacgg cctgccgggc
     8341 atgaacaccg agtcgatgcg gcagtacctg gagtgcgtgg ccgaccagcg gctcacgcgc
     8401 ctgggcttcg ccccggtgta cggctcggag aacccgttct ccttcatgga gctgcagggc
     8461 gttcaggagc tgacgaactt cttcgagcgc cgcccgtcgg cgtaccaggt cgcggtcgag
     8521 ggcacggtcg acctggacga ggacttctga gcccgtctcg ccgtcaaccg aacgcctgcc
     8581 ggcgcgcgtt ccgggcccgc aggccgcttg agcgcacgcc ggtagcaggt gatctaccag
     8641 ggcatcgccc gcagtcgcag atcgtgcggg cgcagggtga tgcccacccg ggtcgtgtcg
     8701 ttcgacccgc tgacctgctc gaagcggtac ttcgccgaga tcgccgcggt gatcaggctc
     8761 agctgggtca tcgagaagtg gtcgctgggg cacttgcggt tgccgacgct gaaggggctc
     8821 atggcgtact tcggtacgtc cttggcccgc tccggcagcc atcggtcggg gtcgaagtcg
     8881 aggtggcggt cgtacgagtg ggcgtcgcgc tggatcgcgt acgggctgta gacgatgtcc
     8941 gccccggccg gaatgcgata cccgccgagt tcggtgtccg tcaccgcgcg ccgcgtcaat
     9001 atccatacgg cgggcctgag ccgcatggcc tcgacgacga cattgttggt gtgcgtgagt
     9061 gtgcggacgt gctcgaatcc gaccggtcgg ccgccggtca cggattcgac ctcggtccgt
     9121 accttctcgg cgtgttccgg gtgttccgcg agcacctgca gcagccacat gatcgtggag
     9181 gcgactgttt cgctgccggg ggtgagtatc gcgacgacct ggtcgtggat ctcctgttcg
     9241 ccgatggggt cgccattgtc gtccttcgcc tccagcaatg ccgtcagcaa atcgtccggc
     9301 ttttgaccag atgccctccg ctcggcgacg atctcgtcga ccagcagatg caaatcggcc
     9361 agcgcccggt tgaattcgcg gttggccggg aacggcagcc ggtacagcgg cccgagcggg
     9421 acgaccatgc gccggtacat gccgcggaag acggaggcga ggtcgacgct gagccgctcg
     9481 gcgcgctcgt ccatgtagtc gccgcgcagc aggcagcggg cggcgatgcg gacggcgacc
     9541 cggaaggact cggaggtgca gtcgatggtc tcgccgggcc gccagcgctc ggtcagcgca
     9601 tgcgcctcct cctgcatgat cggtccgtag tcggggatgg cgtccagccg gaacgcgggc
     9661 tggatggtgc ggcgctggcg gcggtgccgg ggcccgttgg cggtggccac gccctccttg
     9721 ccgagcagcc cttccaggga ctcccacagg ggtccgtcga tcttgaagtc ggggctgagc
     9781 gcgagcgcgc cggtgagcgc cggggtggtg acggcgtaca ccgtcttggg gccgagcttg
     9841 aggcgtacga cgtcgccgtg ctcgcggagc cgggacatga aggcgagcgg atcacggacc
     9901 agtttcaggc cgtgcccgag gcccggcacg gccccgccgg ccaggggcgg ttcgcgcagt
     9961 tcggaggtct cgggggtcag gggctgcgca gactcgacgg tcatttctca cctgccgctt
    10021 cgttcgtgac gtacgggggc gtggaccggt cgtcccaggt gtcgaccatg taccggccgg
    10081 actcgtggtg gaaccagtac acggagctga accagttgcg catattgccg acacaggcgc
    10141 gcaccgcggt gctcaattcc tttccgcgga ccgtaccgtc ggcgagttgg tcggcgaacc
    10201 gcagggcgac ctgctctgct tcgaggaatt cgctgatgca ttcctcgacg cgccgcctta
    10261 cttcgtccac cgcttcctcg agactcagcc cctcatgggt gatgaggctg attccgagat
    10321 tgtggacctc gtcgcccgct atttccttcg gcagcgagca gagatcgttg taccaggcgg
    10381 cgaattcctg gctgagcaga gccgcccggc gataggccgg gtttttcctt atggcgttcg
    10441 ggagttcgca ccccgcactc ggctcgagca ggtccgtcca aatccagtgc gcgaaggtat
    10501 gccggcgcag ggcgagatat tcctcgacac cgggtatgta tcccgtggtg cggttgcgga
    10561 actcgcggtc gtaggcctcg accaccgcgt ggaagtgccg ggcgaaccgc tggttccagg
    10621 tgcgcggcag gaagccgtac agccgcagca cgctgtccgc gaaccccgcg accagcggat
    10681 ccgggtggtg cagatggtgc cggggtgcgt cgagggccgc gtgcaggcgg tacctcagcc
    10741 gccgccaggc accgacccgg ccgtggaccc tgtcccggtc gtgacggtcg tcccagacga
    10801 agaaccacgc gctgtagtcg gcgatggcct gcaggacctc ctcaggggcg ccgaggtagt
    10861 agcccgccat caggtccgtg tagcaaagtc cgtcggcata ttcatgcacc ttgtccgccg
    10921 gcatgaaccg tttttccagc agccagcgtc gtgtcatctg ctggagccgc ggccaatacg
    10981 gatgcagttg ccggggaaag gcggactcga tcaccggaag taccagtgag ggtggtacta
    11041 cgaccgccgt cggcgtcgcg gtggtgctgt gtgggaaagc ttgcacggac aaacccctct
    11101 cagccgcctg gagcgcacgc cccccggtgt gccgggcgcg cgccgctgcg tatcccgccc
    11161 tccccattca gcaccacaac tgaccgccag gggaacggat ttgcttcact cactacccca
    11221 aggtgccgag aatctccccc cacatgaccg attagggatc acaacaagca cagaagggac
    11281 cggttgcaca acgcacggac ggacacacgg acgagcgagg cgtgctcgta cgaagggcgc
    11341 ccgacaggga gtgatccccg tcgggcgccc aggcaggccg gtgccggcta gtcgttcgcg
    11401 accaccggat aacgtggctc gttctcgccc atctgccgca gcgcatcctt gcggtcccgc
    11461 ttggacagcc ggtcgatgta caggtagccg tagaggtggt cggtctcgtg ctgcaaacac
    11521 cgtgcgaagt aaccggtgcc gcggaccttg atcgggttgc cctgttcgtc ctggccggtg
    11581 acctcggcgt agtcgggacg ggcgagcggc gcgtaggccg tcggcacgga gaggcagccc
    11641 tcgttgctgt cgtccagccg gcgcttgtcg gccggcaggt cgaccagctt cgggttgcac
    11701 accacgccca cgtgccgggc gccctcgtcg tccatgcagt cgtagacgaa gaccttcagg
    11761 tcgacaccga tctggttggc ggcgaggccc acgccctcgg cggtgcgctg gctggcgaac
    11821 atgtcggcgg ccagctgccc cagctcctcg ccgaactcgg tgacgtcctt gcactccttg
    11881 tgcagcaccg ggttgccgac gaccgtgatg ggccgcgagg tcccacgctc ccgccaggcc
    11941 ttctcgcgct cctcgcagtc ctccgtgtcg acgacatagc cctcgtcgtc gacggggagc
    12001 acgcccgcgt gctgctgatc ggtgtcctgc tgcgccatga ccgacgtacg ccttcctgca
    12061 caaaatctga gagtgaatgc tgatacaggg tacgtgggcg cgccccgcag gggcgcgggg
    12121 aactgcgcga ccagccacaa cggactctca gtcggcagac tgcctcagca cacctcttcg
    12181 agatcccgcc aatcacgcga gtccgggctg tcagccaccc acccgtccag caacccacga
    12241 accagcgagg ccggcgcagc caccccgcac tcccgctccg gcacccacag ctgcccgtcc
    12301 gtccgatggc cgagcggccc gggatgaccg ggctcactgt ggtcgtgcgg gtccaggtga
    12361 accccttcgc cctcatccga cggcatccgc gactccgagc acatccggca cagcagccgc
    12421 accgaggagg accagtcctc cgcggcgaac cccgcgtccg cggccagctg ctccagcgcg
    12481 tcccggtccg cctccgtggc cgcctccagc aggaccaccc aggtcggcac gggtgagggc
    12541 gcccacagct cgatctcgtc gaagaccggg taggcatggc cggtggacgt cgtgcgctcg
    12601 ccgtgcggga cgccgtcgtg caggacgacc tcgccccagc gccgcccgga cgagggaagc
    12661 gggatggaga gcacctcgat ccgcgccggg tccagcctgc ggccccagac gacctcggcc
    12721 tcaccctccg gagagagccg tacggccgcg ctgcccagct ccatgccgac cggttccgtg
    12781 gccacggtgg cgccgccggg caccttcagc ccgtacgcct gccaggcgcg gcgggccagc
    12841 ggccagtcct gcagggcggt ggcggcgata ccgacgttcc accagtcggg cgccccggcc
    12901 tcccggtcca gcagcgccac cgcgcggagc ccggccgcgc gggcctgctc ccagtcgtgc
    12961 cggaacttgt gcagcagggc gaggttgaac caggactccg acagccaggg ctccaggtcg
    13021 gcggcccgtg tcagcagctc gcccgcgtcc tcgtaccggc cgtcgccgat cagcgtgaaa
    13081 gcacggtcgg tggcctgccg ccaggaggcg gagggccggt gccgtccctt gccgaagatc
    13141 ctcacgattc ccgcctgcca gttccagttc cgctcagtgg gctggcttgt gcccccggac
    13201 accctctccc tcgcatccaa ccacgtacgg cgggaaaggc gctcattacc catgggttac
    13261 ccagcggcgg gcagggtcag acagtgccgt acctctcccg tcgtcgtcca ccggcgcgcg
    13321 ctggggccag gcccgtggcc gggccagcac ccgggcgagg gactccacca cctcgggagc
    13381 gtagtcaccg gcggtgccga ggcgcagttc ctccagtgcc cgcagggggc cctcggggcc
    13441 ggcgtcccgg ctcttctcct cgtaggcgtt cacggcccgg atgatccgcg cggcgagcgg
    13501 ctgttcgcgg taggggtccg cctgccgttc caccatcacg gcgacggccg cggccacccc
    13561 ggtctgccgg acgacggcgc cgccgagcag cgcgatgcgc cgctgttcct ccgggggcag
    13621 ctcggcggtg gcgccggccg ggaccgggtc gagcaggctg agctggccga tgtcgtgcat
    13681 gagggccgcg tactccagaa cggtcagttc tccctcggtc aggccgagat cccggccgac
    13741 ggcgaggctg agcgcggcga cccggcgggc gtgcccggcg ggggcgcacc cggctatctc
    13801 ggtggcgcgg gccagggagg cgatggtctg ccgataggtg gcgcggacgg ccgcgtaccg
    13861 gcgcacggac aactgggtga gcagcagggg cagacagaac acgggcagcg cccacagccc
    13921 gacgacggcg accgcgagcg ccatcaccgc gccggtcgcg cagacggcgg agccgatgcc
    13981 gagcagcccg cgcagctcct cgcgcagcag cgggccgaag ggccagcggg tgcgggagcg
    14041 ggcgagagcg gcggccagaa cggcgtcgca cagggcggtg agaccgagca gggtgaccag
    14101 gaggagggcg taggcggggc cgttccaggc ggcgaacagg cccttgttgt acaggggttg
    14161 gaagcagacg gcggtgaagc cgacggtgag cacgcggcgg gccagagggt cgagggtggg
    14221 ggtgcgcccg gaccagatgt gcggtacggc gccgagcagg gcggcggcga ggacgacggt
    14281 gacgacctgc gccgggcctg cttgcgtggg ccgcccggcg tccgctccga gcagggcgta
    14341 cgacagcgag ccggcggtgc cgaggggcgc ggcctgccgt acctgggcgc cgctccaccg
    14401 ggtcagctcg ccgacggcta tgagcacccc gaaggcgagc gcgacgcccc ggtcgtcgag
    14461 gccggtccac agcgtgacgg cgagggagcc ggccgcggtg agggcggcgg cgccgtggac
    14521 gatgcgcagg gcggtcaccg gggtgccccg gagaccggct tccggccccg cagctcgtac
    14581 ggtgtctcgt cggcggtgac cgtgggatgc cagccgtagc ggcccagcgc acgggcgagc
    14641 gccccgacca tccgggggtc gaactgcgtg cccgcgcagc gccccagctc ggcgacggcc
    14701 gcctcgacgg gccgggccct gcggtaggag cgggtggagg tcatggcgtc gaaggcgtcg
    14761 gcgacggcga cgacccgggc gcactcgggg atctgggtgc cgacgaggcc gtacgggtag
    14821 ccggtgccgt cgaggcgttc atggtggtgc agaatcgcgg cgcgggcctc accgaggaag
    14881 gagatcccgc ggaccatctc atggccgtac tcggggtgca gttcgatgat ccggcgttcc
    14941 tcgggggtga gcgggccgtc cttgcgcagc agccgggtgg ggacgccgag cttgccgacg
    15001 tcgtgcagga tgccggcgaa gcgcagcacc tcgacgcgct cgtcgtccat gccgagttcg
    15061 cgggcgatca tcacggaggc ctgtccgacg cgttcgctgt ggccgcgggt gtagccgtcc
    15121 ttgatgtcga cggcctgcac gagcgcgcgg atggtggcct ggtgggcggc gcgttcgcgg
    15181 tggtactggg cgaagatcca ccaggacacg cacatcggca gcagcaccag cagggccgcg
    15241 accgggccgt acgggctgcg ccacagcacg gccatcatca gcccggcgag tccgtgcacc
    15301 gcgaccggcg cgagcgagcg ggacagcagc ccgcgccagg cccggcgcag cgggacgccc
    15361 agggcgaccg cgcggatgcc gccgtcgagg acggtgagga tcaggcagaa ggcgaggacg
    15421 gccgcgccga cgggcagcag cgcgtacggg aagtgacagt cgacgacggc gttccggccg
    15481 ccgagcgccc agtgcacccg ggcggnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15541 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15601 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15661 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15721 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    15961 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16021 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16081 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16141 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16201 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16261 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16321 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16381 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16441 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16501 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    16561 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnac gagcgcggcg gccggcgggg
    16621 gcagcaggaa cgccccggcg agcaggacgg ggtagaaggt gccgccgaag cggcggcgta
    16681 cgacgtgctc gcaaccggcg tagagcgccg agagcaggct gagcgcccac cagggggtgc
    16741 ggatcgtcgg cagcggcagc agacagaaca gcgccagcag ggcgacgacg gccacgaagc
    16801 cgcgtgcccg cgccgaatcc gcctccatcg cccgtccctc cccgaccatg cctgtccggg
    16861 ctcggagcct agggcgggaa tcggggatgc agggcttatg acctgaggat tagcacgttc
    16921 gggtgacggg gtggtgaccc ggtgctcagc cgtcctgcgg ggtggcggtg atgtcgtgct
    16981 ccggcacggc ctgaccggaa cggatcaggt cgatccgccc catgaccttg gcccgcaggt
    17041 ccgcgggcac gtcgtcatgc ccgcagcacc gcttgaccag cttcttcacg gcctgctcca
    17101 ggccgtactt ctccaggcac ggagagcatt cctcgaagtg gtgccggaac ttgtcccggt
    17161 cgatgtccgg catctcgctg tcgaggaact cgtacagatg gtcgagtacc tcactgcagt
    17221 ccgtctcgtg cggctctccg cagctcatga gcccgagcct ttcgcttcgt tcgactctcc
    17281 ggcgcccgcc gggaccagcc cgcggtcacg ggcgtagtcc tccagcatgc cgcgcagctg
    17341 acggcggcct cggtgcagcc gggacatcac cgtaccgatg ggggtcccca tgatgtccgc
    17401 gatctccttg tacgcaaagc cctccacgtc cgcgagatag acggcgatgc ggaactcctc
    17461 ggggatcgcc tgcagcgctt ccttgacgtc cgagtcgggc aggtggtcga gcgcctgcga
    17521 ctcggcggag cgcagacccg tcgacatgtg cgactcggcg cgggcgagct gccagtcctc
    17581 gatctcctcc gcggcggagc gctggggctc gcgctgcttc ttgcggtagg agttgatgaa
    17641 ggtgttggtg aggatccggt acagccacgc cttgaggttg gtgccctcgc ggaactggtg
    17701 gaaggacgcg tacgccttcg cgtaggtctc ctgcaccagg tcctcggcgt cggccgggtt
    17761 gcgcgtcatg cgcagcgcgg ccgagtacat ctggtcgagg aattcgagcg cgtcccgctc
    17821 gaagcgcgca ctgcgctccg cggtcgactc ggctgccgcc tccgcgctca cgccctggcc
    17881 ctcgggctgc tccgcctggc cgttgtcggt ccctgcgtcg gtaccggtga ccggacccac
    17941 ctcctcaaga tcccgggcag gaccgagacc ggccccactc gattcggagg atagaacacg
    18001 acctgtgcct gccgcccctc gaatatgagc ggtcctggcc gcgtgcagca ccgtccagtc
    18061 caggtcggta cggctgctgc gggaatcgag agaggccgcg cgcagcgcgt cgctggaagg
    18121 gcggtggtgg gcgacgggcg ggcagatggt cgaacccatg cggcggactt cctctcctac
    18181 gacgtcggtg ccgaggcctc agcacttctg tccgccacaa cagtggtccg gcgcggagca
    18241 ttcccggccg tcacccgagt gacgccagcc actccgcgac gctctcggtg atgatctcca
    18301 gggcccgctc ctgagtgatc ccggcgcgct tggggaccgc gaagccatgg tccccgtacg
    18361 ccacctcgac cagctcgtac gagcccttgg ggaattcctc cggcttcccg aaggggtcgt
    18421 tgccgccctg cacgaccagc gtgggcaccc cggccccgag cagttccgcg gcgcgcgact
    18481 tctccggctt gcccggcggg tgcaacggga agctcagcgc gagcacggcg tgcgcgccca
    18541 gcccggccgc cgtacggcag gcgacccggg ccccggcgct ccgcccgccg gagaccacgg
    18601 gcagctccat cccggccagc gcgggccaga tgtcgcgcca cccggcgtcc agggtcttcg
    18661 gcgcgggcgc gaccttcttg cccgcgaccc gccagggctg ctcgacgagg gcgacggtga
    18721 cgccgtgcgc ggggagagcg tgggcgagtg cctggaggtc acgcgcctcg acgcctccgc
    18781 cggcgccgtg gctcagggcg aggaccagcc cgggatcctc cgcccggtgc caggtgatgc
    18841 gtgcggttcc tgcgtcggtc tcgacaatct cgatcacgct agaagagtgt gccctcttcc
    18901 ggggccgcaa gctccttcag cagctccggt ccgttgttgc ggacgttgct gacggccgtg
    18961 gagaccgggt aggcgcgcat caaaccgggc ggcggcgggg ccagcagctc gcgcaggtcg
    19021 tcggggtcgg tgcggcccgg gtcgagccag gcgtcccagc ggtccggggt gagcatcagc
    19081 ggcatgcggg ggtggatgtc ggccagggcg tgcgggccct cggcgggggc cacggccagc
    19141 ggcgtcctct cggcctccgt ggtgatcacc gagcaggtgg cccaccaggc ccgcgggtgg
    19201 tcgtcgggca gggtccggtc gcgccagaac tcgtacagac cggccatcgc gaacaccgag
    19261 ccgtcggccg gcagcacgaa gtacggctgc ttgcgcggcc gcttcttctt gccctcggcc
    19321 tccagttcgc gctcgtcctt gccggtgacc cactcgtagt agccgtcggc gggcaggatg
    19381 cagcgccggg cggcgaaggc acgccggtag gagggcttct cgtgcaccgt ctcggcgcgc
    19441 gcgttgatca tccgggcgcc gccctcgggc gtcttggccc aggacggcac cagtccccac
    19501 ttcagcttgc gcagctggcg aaccggacgc ggggagtccg cgtctttcag gggacggtcc
    19561 aggacggcgt agacctcctt ggtcggcgcc acgttgtagt ccggctcaag ggtctcttcc
    19621 ggctcccact tctcgatctc aaagactcct gcgagatcct cgggcctacg actcgatgca
    19681 taccgtccgc acatacgtgc cacactgcca gactccgcac gacgacagga gccactcgga
    19741 catatggaca gcctcgccgc cacctcgctg accggcctct gggaccggct caccggcacc
    19801 cagcccgacc cggccctgtg ggtggtgctc gccacgctgg ccgccgcgct cgccgtcatc
    19861 gtgccgcacg gcccgtggcg gatatcgcgc aacgcgatca ccatcgccca cgagggcggc
    19921 cacgggctga tcgcgctgct caccggccgg cagctcaccg gtatccggct gcactccgac
    19981 accagcggcc tcacggtcag ccggggcaag ccgcacgggc tgggcatgat cctgacagcc
    20041 gccgccggat acacggcgcc ctcgctgctg ggcctcggcg gcgccgcgct gctggccacg
    20101 ggccgcatca cactgctgct gtgggtggcg acggcgctgc tcgtggtgat gctggtgatg
    20161 atccgcaacg cgtacggcgt gctgaccgtg gtgctgaccg ggggcgcctt cctgctggtg
    20221 tcctggctgg cggggcccca ggtgcaggcg gcgttcgcgt acgcggtggt gtggttcctg
    20281 ctgttcggcg gggtacggcc gccgttcgag ctgcagctga agcggtcccg gggtggcgcg
    20341 ggcgactcgg acgcggacca gctgtcgcgg ctcacgcacg taccggcggg gctgtggctg
    20401 ttcctgttcc acgcggtgac cctgtcctcg ctgatcggcg ggggccgctg gctgctggag
    20461 ctgtgagggc agacgggcgc cggctccctg tccttgccgc gttttcgtcg ggatttcggc
    20521 gcttttgatc gagatctgcc gtggtcccca gccactaaag tggggcgcat gaccgttaac
    20581 cccgcacact ccgccctctg gcccgccccg cacgcgagcg gagccgtcga cgcgacggtc
    20641 cacgtgcccg ggtccaagtc ggtcaccaac cgcgcgctgg tgctggccgc cctcgcctcc
    20701 gagcccggct ggctgcgccg cccgctgcgc tcccgcgaca ccctgctgat ggccggtgcc
    20761 ctcagggcca tgggcgtgga gatcgaggaa ggggtcggcc ccgacggcac cggcgaggcc
    20821 tggcgggtgc tgccgacggg cctgcacggc ccggccacgg tcgacgtcgg caacgccggc
    20881 acggtgatgc gcttcctgcc gccggtggcc gcgctggccg acggccccat ccggttcgac
    20941 ggcgacccgc ggtcgtacga gcgccccctg cacggcgtga tcgacgcgct gcggcagctc
    21001 ggcgcccgga tcgacgacga cggccggggc gcgctgccgc tgaccgtgca cggcggcggg
    21061 gccctggacg gcggcccggt gtcggt
//
