LOCUS       NZ_CM002285            22163 bp    DNA     linear   CON 29-APR-2024
DEFINITION  Streptomyces roseochromogenus subsp. oscitans DS 12.976 chromosome,
            whole genome shotgun sequence.
ACCESSION   NZ_CM002285
VERSION     NZ_CM002285.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces roseochromogenus subsp. oscitans DS 12.976
  ORGANISM  Streptomyces roseochromogenus subsp. oscitans DS 12.976
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Kalinowski,J., Heide,L. and Apel,A.K.
  TITLE     Draft Genome Sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976, Producer of the Aminocoumarin Antibiotic
            Clorobiocin
  JOURNAL   Genome Announc 2 (1), e01147-13 (2014)
   PUBMED   24407645
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Draft genome sequence of Streptomyces roseochromogenes subsp.
            oscitans DS 12.976
  JOURNAL   Unpublished
REFERENCE   3  (bases 1 to 9663240)
  AUTHORS   Ruckert,C., Szczepanowski,R., Heide,L., Kalinowski,J. and Apel,A.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-SEP-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.5.3
            Assembly Name                     :: S.roseochromogenes_v1
            Genome Coverage                   :: 20.4x
            Sequencing Technology             :: 454
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000497445.1-RS_2024_04_29
            Annotation Date                   :: 04/29/2024 03:44:08
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,098
            CDSs (total)                      :: 9,013
            Genes (coding)                    :: 8,393
            CDSs (with protein)               :: 8,393
            Genes (RNA)                       :: 85
            rRNAs                             :: 6, 6 (16S, 23S)
            complete rRNAs                    :: 6, 6 (16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 620
            CDSs (without protein)            :: 620
            Pseudo Genes (ambiguous residues) :: 0 of 620
            Pseudo Genes (frameshifted)       :: 227 of 620
            Pseudo Genes (incomplete)         :: 534 of 620
            Pseudo Genes (internal stop)      :: 54 of 620
            Pseudo Genes (multiple problems)  :: 178 of 620
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:03:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2063190
            Orig. end                         :: 2085353
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002285.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="14"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12163](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12163)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(12..563)
                     /locus_tag="M878_RS58935"
                     /old_locus_tag="M878_09550"
     CDS             complement(12..563)
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385491.1"
                     /locus_tag="M878_RS58935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09550"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_023545888.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDAERDKALQVLRDGVAMGRLSHDTFVRRME
                     LALAARRSDELAALVADLPRENRFSRAVLGTVEAVSGFTVRLRRAWQAERLPKLLLPNP
                     ARTHPLRIGRDPANGLRLNHETVSRVHAELSHQGGIWVLRDLGSTNGTTVNGRRVIGSV
                     VVREGDQVAFGRTAFRLAVN"
     gene            754..2499
                     /gene="treZ"
                     /locus_tag="M878_RS58940"
                     /old_locus_tag="M878_09555"
     CDS             754..2499
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675705.1"
                     /locus_tag="M878_RS58940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09555"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_031224583.1"
                     /sec_met_domain="Alpha-amylase (E-value: 1.9e-10, bitscore:
                     39.9, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLHCEGATRALARDPARAGWWTGEAEAEDGTR
                     YGFALDDGPVLPDPRSRRQPDGPDGLSAVVDHGRHAWRTRWTGRGLPGAVLYELHVGTY
                     TPEGTLDAAASRLEHLVELGITHVELMPLCPFPGRRGWGYEGVSPWAVHEPYGGPEALK
                     RFVDQAHELGLGVVLDVVHNHLGPSGNHLPAFGPYFTETHHTPWGTAVNLDAPGSDEVR
                     AYFLGSALAWLRDYRIDGLRLDAVHALYDTRACHFLEELSAAVDGLAGELGRPLFLIAE
                     SDLNDPRIITPRAEHGLGLHAQWNDDFHHALHTALTGESQGYYADFAEAPFAALAKALT
                     GGYFHDGTYSSFRGRHHGRPLDRTRVAGHRLLGYSQTHDQVGNRAQGDRLSARLSPGLL
                     ACAATLTLTSPFTPMLFMGEEWAAGTPWQFFTDHTDPELAEAVRRGRRREFAAHGWAEE
                     DVPDPQDPATRDRSVLDWSEPEREHHARVLAWYRRLIALRHEQPDLTDPDLADTRVAYD
                     EESRWLAFRRGDVRVAVNLGKEPAAIPLGTRPALVLAAWDPVDPPGPDGLLHVPGESCV
                     ILSQP"
     gene            complement(<2580..2714)
                     /locus_tag="M878_RS000000101370"
                     /pseudo=""
     CDS             complement(<2580..2714)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241837.1"
                     /locus_tag="M878_RS000000101370"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DNA-binding response regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVELPGARGCEVVATSGTAPELLAAVDEHRPNVAVVDIGMPPTHS
                     "
     gene            complement(2920..3858)
                     /locus_tag="M878_RS58945"
                     /old_locus_tag="M878_09560"
     CDS             complement(2920..3858)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675704.1"
                     /locus_tag="M878_RS58945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09560"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_023545890.1"
                     /sec_met_domain="APH (E-value: 3e-20, bitscore: 72.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLKEGGDGTAGPDVRPVREGGEHSTWW
                     VGTRHVLRLAPDREATVRQRRELRLRDLARPHLPVAVPASVAHGEWAPGLGYTLDTAIP
                     GGSAEEHDVSAVGEADLAGLLTGLRAVPVRQVEALGVPRTAPRSLEALRRMAVHAAERL
                     ATADEFDAARLHQLTPPGAAQLAAQSGTAVLVHHDLKGEHLVVSADGRVRGVLDWTGAA
                     LGDPAEDIAGLVLAVGSGAAVRAATLAGYGPRPCLRGLWLARCDTVVSLADRLDGRDDS
                     PLPLLRTQLERAWEPILLERLTDFKEDEQEP"
     misc_feature    3913..3933
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.03"
                     /tool="antismash"
     gene            complement(3960..5087)
                     /locus_tag="M878_RS58950"
                     /old_locus_tag="M878_09565"
     CDS             complement(3960..5087)
                     /EC_number="3.4.11.9"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="M878_RS58950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09565"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_023545891.1"
                     /transl_table=11
                     /translation="MTGSTPAPFTAADYRARMERAARSAADAGLAGLLVAPGPDMVWLT
                     GYTPTAVTERLTVLLLTPGHEPVLVVPTLEAPDAEHATGASALTLRDWTDGKDPYTVTA
                     ALLDGRGRFGISDNTWAMHLLGFQRALPDTSYASLTDALPMLRAVKDAAELELLAAAGA
                     AADATFEEIRKVPFAGRRESDVGRDLADLLRRFGHSQVDFTIVGSGPNGANPHHEVGDR
                     VIQHGDMVVLDFGGLKDGYGSDTTRTVHVGEPSDEERRVHDIVREAQEAGCQAVRPGAA
                     CQEVDRAARAVITDAGYGAYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTVTEDGGRRLNNTTREMVIVD"
     gene            complement(5367..5942)
                     /locus_tag="M878_RS58955"
                     /old_locus_tag="M878_09570"
     CDS             complement(5367..5942)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657043.1"
                     /locus_tag="M878_RS58955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09570"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_023545892.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQDRREAGTPGPAHRPHAAPRRGRRLRTVLFGL
                     FTGGVLVLSGVGIGTVGATVIGMSRLAELQRQAPSAAPPAKATPTTPAGTPGPAPAHLP
                     GATLGIEAVDADKVGALVVGVHVPGPGYAAGLVRGDDVLQFGSARVESAADLARAVDRA
                     RPGKPVLLTVRHSGGGYQQLAVVPGVVT"
     gene            complement(6192..7067)
                     /locus_tag="M878_RS58960"
                     /old_locus_tag="M878_09575"
     CDS             complement(6192..7067)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125299.1"
                     /locus_tag="M878_RS58960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09575"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_023545893.1"
                     /transl_table=11
                     /translation="MDPHLLRTFVTVARLASFSEAARKLGYTQSAVSQHIAALEQDLGA
                     PLLTRRPVVPTAAGERLLEHAGPLLLRLDAARADVVRMTAAPRHGLTLATTPTALGVGV
                     LAALPPAGVTLRVLTREEIPAAVATGTADLGLVDGLAAPSDPLRLPDVAPLTTHGVAEE
                     PVSVLLPEGHPLAARTGLRLGDLADARWLDAPDAALPLDHLRAATGGGAFRSALRYEGT
                     DLHTLTALAAAGHGLTLLPRRVATAVPGTAAVPLTAPRVVHRTELIHGGRPGGSAEGVV
                     RRLVGAGRVG"
     misc_feature    complement(7147..7161)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            7161..7883
                     /locus_tag="M878_RS58965"
                     /old_locus_tag="M878_09580"
     CDS             7161..7883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547157.1"
                     /locus_tag="M878_RS58965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09580"
                     /product="hypothetical protein"
                     /protein_id="WP_023545894.1"
                     /transl_table=11
                     /translation="MNTTATLALVGDRSPDVVSHTRVPLLLEALAERDRLVLDAYWIPS
                     EEAEAEGAVRGFDAVWVLPGSPYRSEAGVLAAVRTAREEGIPFLGTCGGFQHALLEYAR
                     NVCGLTGVAHAENDPEATDPLIEPLACSLVGHEAAVTIEPGSLAESVIGSARTVERYFC
                     AYGPSRHLDTLRAHGLRFSGHDEDGHPRVAELPGHPFFLASLFQPELAGDGSRPHPMIR
                     ALARAAVEHASSRIAPPA"
     gene            complement(7997..9886)
                     /gene="phsA"
                     /locus_tag="M878_RS58970"
                     /old_locus_tag="M878_09585"
     CDS             complement(7997..9886)
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675701.1"
                     /locus_tag="M878_RS58970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09585"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_023545895.1"
                     /transl_table=11
                     /translation="MTETIGRLTEGTRQTGEQEQAVDELAPYMAPLTVPPVLCPAADDV
                     PRETEIAVRPTWVRLHPQLPPTLMWGYDGQVPGPTIEVRRGQRVRIAWTNRIPKDAEYP
                     VTSVEVPARAPGTPPASTEPGREGVEPDKDVAALPAWTVTHLHGAQTGGGNDGWADNAV
                     GHGDAQLSEYPNDHQAVQWWYHDHAMNITRWNVMTGLYGTYLLRDDEEDALHLPSGERE
                     IPLLLADRNLDTDEDGRLNGRLLHKTVIVQQSNPETGKPVSVPFTGPYTTVNGRIWPYA
                     EVDAAWYRFRLLNASNARIFQLVLIDEDGNPVPGVVYQIGSDGGLLPRPVPVGFDGELP
                     TLTAAPAERFDLLVDFRALAGRTLRLVNKGPNQPAGVPDPAGDVRYPAVLEFRVGETGE
                     EDIFELPEVLSGSFRRLTHDLPHGHRMVLLTPPATKGAGGHPEIWELTEVEDPSGLRLP
                     ADGIVQVTGLDGTTKTYRRTSRTFNDGLGFTIAEGGYEQWSFLNLAPIVHPMHIHLADF
                     QLLGRDAYDVSGFDPALGGTRTPLRYDADRVIPLAPNERGNKDVFRVPGSQMLRVMGRF
                     DGAYGRFMYHCRLLEHEDMGMMRPFVVMPAEAMKFDHGAGHGGHGGHGEGHMG"
     gene            complement(10001..12163)
                     /gene="cyc2"
                     /locus_tag="M878_RS58975"
                     /old_locus_tag="M878_09590"
     CDS             complement(10001..12163)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675700.1"
                     /locus_tag="M878_RS58975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09590"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_023545896.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-80, bitscore: 270.9,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHLDEARAHSTEWAREMGMLEGSGIW
                     EQADLEAHDYGLLCSYTHPDCDGTALSLITDWYVWVFFFDDHFLDMFKRTQDRAAGKAH
                     LDRLPLFMPLDPATPVPEPENPVEAGLKDLWARTVPSMSVDWRRRFSVATEHLLNESMW
                     ELSNMNEGRIANPVEYIEMRRKVGGAPWSSGLVEYATAEVPAAVAGTRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGENSNGVLVLETFFGCTTQEAAETVNDILTSRLHQFEHTAL
                     TEVPAVALEKGLTPEQTAAVAAYTKGLQDWQSGGHEWHMRSSRYMNKGARPDAPWQLLT
                     GPGTSAADVAALLATAARERLRAYGHVPYQKVGPSILPEFHMPYELGLSPHLDGARRNL
                     LAWSHRMGILEEGVWDEDKLAAYDLALCSAGLDPDATPEALDLSAQWLAWGTYADDYYP
                     LVYGRRRDLAGARLSTARLSACMPVEGEPSVVPADAMERGLVDLWARTTAGMTTEQRQT
                     LKDAVDVMTESWVWELSNQLQNRIPDPVDYLEMRRATFGSDLTLILCRMGHGPAIPPEV
                     YRSGPVRALENAAIDYACLINDVFSYQKEIEYEGEIHNAILVVQNFFGVDYPAALGVVH
                     DLMTQRMQQFEHVIAQELPVLYDDFGLSEEGRAAMDGYVLDLQNWLAGILNWHREVDRY
                     KAEWLGRRSHGFVPDRAPAVPALSFG"
     gene            12328..>13092
                     /locus_tag="M878_RS47430"
                     /old_locus_tag="M878_09595"
                     /pseudo=""
     CDS             12328..>13092
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-239). E-value:
                     5.1e-25. Score: 80.4. Matches aSDomain:
                     nrpspksdomains_M878_RS47430_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675699.1"
                     /locus_tag="M878_RS47430"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09595"
                     /product="alpha/beta hydrolase"
                     /pseudo=""
                     /sec_met_domain="Abhydrolase_6 (E-value: 2e-16, bitscore:
                     60.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.3e-19, bitscore: 69.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFVLPHEVHGDGAHKVFAVHGWFADRSAYAAVLPDLDRTAFTY
                     ALVDLRGYGEAQDAVGAYTTAEAAADLVELADRLGWQRFSVLGHSMGGAVAQRLAAVVP
                     HRLRRIVGVSPVPASGVPLAGEQAALFSDAAHKPENRRAILDLTTGGRRPAAWLDRMVA
                     RSLERSDAKACRAWLDSWAGDDFHADVEGSEVPALAVAGGLDPALSPEVMRQTWLSWYP
                     RAELVTLPFAGHYAMDECPLELIRVVEDFLRAD"
     aSDomain        12388..13044
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M878_RS47430_Abhydrolase_1.1"
                     /evalue="5.10E-25"
                     /label="M878_RS47430_Abhydrolase_1.1"
                     /locus_tag="M878_RS47430"
                     /protein_end="239"
                     /protein_start="20"
                     /score="80.4"
                     /tool="antismash"
                     /translation="VHGWFADRSAYAAVLPDLDRTAFTYALVDLRGYGEAQDAVGAYTT
                     AEAAADLVELADRLGWQRFSVLGHSMGGAVAQRLAAVVPHRLRRIVGVSPVPASGVPLA
                     GEQAALFSDAAHKPENRRAILDLTTGGRRPAAWLDRMVARSLERSDAKACRAWLDSWAG
                     DDFHADVEGSEVPALAVAGGLDPALSPEVMRQTWLSWYPRAELVTLPFAGHYAMDE"
     CDS_motif       12583..12630
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M878_RS47430_0001"
                     /evalue="2.20E-05"
                     /label="NRPS-te1"
                     /locus_tag="M878_RS47430"
                     /protein_end="101"
                     /protein_start="85"
                     /score="17.0"
                     /tool="antismash"
                     /translation="VLGHSMGGAVAQRLAA"
     gene            13278..14540
                     /locus_tag="M878_RS58980"
                     /old_locus_tag="M878_09600"
     CDS             13278..14540
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493378.1"
                     /locus_tag="M878_RS58980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09600"
                     /product="cytochrome P450"
                     /protein_id="WP_031224585.1"
                     /sec_met_domain="p450 (E-value: 3.9e-17, bitscore: 61.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVREAPPVPDVFDPRRYAAGVPHDDYRVLRDHHPVAWQEEPEVL
                     GWPAGPGFWAVTRHADVVRVLKDATTYSSHLGATQIRDPDPADLPFIRSMMLNQDPPQH
                     GWLRRLVSRAFTPGRVDRFAAFARERARTLLAGALQRAREGDGTVDLVDCVTDEYALLN
                     LADLLGVPESDRRRLLHWTRRVIGYQDPDEAGPPVLDGTGKPVDPRSPAMLEDMFDYAR
                     RLAAYKRRHPADDVMTTLAGDAELTGAELEMFFFLLTVAGNDTVRSAAPGGLLALTEHP
                     ESYASLRAGKIEMPSAIEELLRWHPPVLTFRRTAARDTELAGQRIRAGDKVVVFHASAN
                     RDERAFADPARLDLTRSPNPHVSFGDGPHVCLGAHFARLQLRLLYEEVLRVLPEPRLAA
                     PPERLVSNFINGIKTLSFDIT"
     gene            complement(14533..15551)
                     /locus_tag="M878_RS58985"
                     /pseudo=""
     CDS             complement(14533..15551)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675697.1"
                     /locus_tag="M878_RS58985"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="damage-control phosphatase ARMT1 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPHAPFASVILGNEPGSFPHSVPAVGVPPAPFRSRGGTPRSSGRC
                     GSPSRTAQGSIGRSWCDVPPAVVRPPAVVRELLLPLAARRGRLVRPRRPAGYRPLPPVQ
                     ARRAPRTGDRRGTGRAGRPALPEEGQACALLHGSLWGNRADLGFRLSAEGAEAREAAPS
                     LVADDSEALWSLLPPDGSATLVLVADNAGRALVPDLPLIAHLLAGGRACGAARQAAPVL
                     RLRCHVR"
     gene            complement(15574..16221)
                     /locus_tag="M878_RS58990"
                     /old_locus_tag="M878_09615"
     CDS             complement(15574..16221)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675696.1"
                     /locus_tag="M878_RS58990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09615"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_023545901.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIITAAADLFDRHGYESTSLSDIVAHAKVTKGA
                     LYFHFAAKEDLAQAILELNARAGKQLVAEVESRGYSSLEALMRTTFGVARLAVEDPVPR
                     AALRLATADIAVRPPLRHPFTEWLEFATRKFTAAVRESDVHSDLDVGVVAHSLVSFFVG
                     TRVAGRSLEPVGRLPRRIAEMWHLLIRGLVPVHRRPRYVTLATQLEREIRTA"
     misc_feature    complement(16207..16209)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16415..16432
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.85"
                     /tool="antismash"
     gene            16718..17488
                     /locus_tag="M878_RS58995"
                     /old_locus_tag="M878_09620"
     CDS             16718..17488
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125293.1"
                     /locus_tag="M878_RS58995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09620"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_023545902.1"
                     /transl_table=11
                     /translation="MTRATARLSVPVAVAAPPLPLLPWAAGSAQAHGAPTAPASRVYAC
                     SPEGGETARPAACRAAVAANGAPFTVWDNLRVAGVNGHDRQVIPDGRLCSGDLPAYRGL
                     DLRRDWPATRLTPGSRLTMTYASTIAHTGTFRLYLTKPGYDPAKPLTWPDLPERPFTQV
                     TDPPLRKGAYHIGARMPTDRTGRQILYTVWQNRSTPETCYSRSDVVFPEKGETPAADKP
                     VAGSGVSTHMPAGGAAAVLVCTGGAALAVRLRRR"
     gene            complement(17507..18160)
                     /locus_tag="M878_RS59000"
                     /old_locus_tag="M878_09625"
     CDS             complement(17507..18160)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="M878_RS59000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09625"
                     /product="hypothetical protein"
                     /protein_id="WP_023545903.1"
                     /transl_table=11
                     /translation="MRTRPLLALAGTATALALALAAPASADGSAVLTTGSAGGTAAATG
                     DTLTAPLASGTSATFYSSATGTSGVTCTSSQFTAKVTGNPTAPGTATESVTGHTFDASS
                     CTSNVPGVTGVSSITVDNLPYTATVGSDGTLTVSPATGSTIQTTVKLKTLLGTITCVYQ
                     APSLSGKADNTDSSISFTSQQFTKSSGSSLCFASGYFTAKYAPVTDGGARVYVN"
     misc_feature    complement(18586..18602)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.45"
                     /tool="antismash"
     misc_feature    18641..18656
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.09"
                     /tool="antismash"
     gene            18836..19579
                     /locus_tag="M878_RS59005"
                     /old_locus_tag="M878_09630"
     CDS             18836..19579
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996942.1"
                     /locus_tag="M878_RS59005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09630"
                     /product="DUF6230 family protein"
                     /protein_id="WP_023545904.1"
                     /transl_table=11
                     /translation="MASSPDVPSAGNTPENPGNGSPSEATEPVRASAAPETDAAPPTAG
                     TAGGGERRGRVRARRAAVMAVPATLVVAGLAVLTAQGALGVQFAISGMPFTVTATELNG
                     TGFEQFGGLDNMADGSPNAGDSGGQELVVTSAIKNATLTKLCQSVDLGGTNLLITAGSG
                     ADKVTASDLTTDSTQLSGDAAFNNIEIGNDASTLTKAGVKGPIGVFSQQADTVRIANLR
                     QTNYATTAGVFKLPGLKLRFSGSGC"
     gene            19591..20088
                     /locus_tag="M878_RS47440"
                     /old_locus_tag="M878_09635"
     CDS             19591..20088
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547164.1"
                     /locus_tag="M878_RS47440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09635"
                     /product="DUF6114 domain-containing protein"
                     /protein_id="WP_245238381.1"
                     /transl_table=11
                     /translation="MSDRPREGARAAFRRWRARRPFWGGLLLALAGGEILLTEKASLKV
                     VMHIGMQGLAGYLLPSLMALLGLLVLFNPAQRLFYSITGVLVSLGTWMTSNLGGFFIGL
                     LLGITGSCLTFGWVPDQEPRISRRERRKQARATVGGHVVGTLPEGATGNQSGSAGTPRA
                     SR"
     gene            20160..20615
                     /locus_tag="M878_RS59010"
                     /old_locus_tag="M878_09640"
     CDS             20160..20615
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675687.1"
                     /locus_tag="M878_RS59010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09640"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_023545906.1"
                     /transl_table=11
                     /translation="MALWDRVKESASQMQTQLTAKKNDLKSGAFRDASMAMCALVAAAD
                     GTVDPSERQRVAQLIATNEVLQNFPADDLRRRFEENLNKLTTDFAFGKVSVLQEIAKAK
                     KKPAEARAVVQIGIVIGGADGDFDKTEQAVVREACYTLDLTPHEFDL"
     gene            20644..21663
                     /locus_tag="M878_RS59015"
                     /old_locus_tag="M878_09645"
     CDS             20644..21663
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983671.1"
                     /locus_tag="M878_RS59015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M878_09645"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_023545907.1"
                     /transl_table=11
                     /translation="MLDALDRALIHALHLDGRVPFSRIAEVLGVSAQTVARRYRRLRAE
                     AGLRVVGLADPDRAGRAQWLVRLTATARSAQDIAGALVRRPDTSWVKLTSGGTEITAVI
                     HAAAEDASPGSLLLHDIPRTGGITAVSAHLLLHTYLGGPANWRRSAQALDEEQQRALEY
                     RGDAVAGEGDREAGDGVRQPGPGDGELFAALERDGRAGQGELARATGWSPTTVARRLAE
                     LRAAGALFFDVEVDAGLFGVRARALLWLSVRPADLEQVALALADHDELAFVAATTGRTN
                     LVAQALCRDPADLHRYLTRRLGSLREIDALETSPVLRTLKSASPVRVAGPRTPTHRAG"
     misc_feature    complement(22071..22086)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
ORIGIN
        1 gccggcgccc ctcagttcac ggcgagccgg aacgccgtcc ggccgaaggc tacctggtcg
       61 ccctcgcgga cgacgaccga gccgatcacg cggcggccgt tgaccgtggt gccgttggtg
      121 gagccgaggt cccgcaggac ccatatgccg ccctggtggc tcagttcggc gtgcacacgg
      181 gagacggtct cgtggttcag gcgcagcccg ttggccgggt cgcggccgat gcgcagcggg
      241 tgggtgcgcg cggggttcgg cagcagcagc ttgggcaacc gctcggcctg ccaggcccgg
      301 cgcagtcgta cggtgaaccc ggagacggcc tcgacggtgc cgaggaccgc acgggagaaa
      361 cggttctcgc ggggcaggtc ggccacgagg gcagccagtt cgtcgctgcg gcgggcggcc
      421 agcgccagct ccatgcggcg cacgaacgtg tcgtgcgaga gccggcccat ggcgacgccg
      481 tcccgcagca cctgcagcgc cttgtcacgc tccgcgtcgg acagccgcgc ggggtacgtg
      541 gagaactcga aagacgacgt cacgctggtg attgtcggtc agtgaacccc gggtgtccag
      601 aaaaccggga atcggcgccg aaccgcgcat acgcccacga caccaccggg aaagggcata
      661 ttcgaaggcg gaatgatcgt cccggcgggc acgatgggga cgcgggacat cacggtgagc
      721 agacgatcca tcacaggcga aggggaaccg tccgtgcagt tcgaggtgtg ggcaccgcag
      781 gcagaccgag tgacgctcca ttgcgagggc gccacgcgcg cgttggcgcg tgatcccgcg
      841 cgcgccggct ggtggacggg ggaggcggag gccgaggacg gaacccggta cgggttcgcg
      901 ctggacgacg gcccggtgct gcccgacccg cgctcgcgcc gccagccgga cggcccggac
      961 gggctgagcg cggtcgtgga ccacgggcgc cacgcgtggc gtacgcgatg gacggggcgg
     1021 gggctgccgg gtgccgtgct gtacgagctg cacgtgggca cgtacacccc cgagggcacc
     1081 ctggacgcgg cggcctcccg gctggagcac ctggtggaac tgggcatcac gcacgtggag
     1141 ttgatgccgc tgtgtccgtt cccggggcgg cgcgggtggg gctacgaggg agtgtcgccg
     1201 tgggcggtgc acgagccgta cggcggcccg gaggcgctga aacgcttcgt cgaccaggcg
     1261 cacgaactcg gtctcggcgt cgttctggac gtcgtgcaca accacttggg cccgtccggc
     1321 aaccatctgc cggccttcgg gccgtacttc accgagacgc accacacgcc gtggggtacg
     1381 gcggtgaacc tggacgcgcc cggctcggac gaggtgcgcg cctacttcct cggcagcgcg
     1441 ctggcatggc tgcgggacta ccggatcgac gggctgcggc tggacgcggt gcacgcgctg
     1501 tacgacacgc gcgcgtgcca cttcctggag gagctgtcgg cggccgtgga cggcctcgcc
     1561 ggggagctgg gccggccgct gttcctcatc gccgagtcgg acctgaacga cccgcggatc
     1621 atcaccccgc gcgcggagca cggcctcggg ctgcacgcgc agtggaacga cgacttccac
     1681 cacgccctgc acaccgcgct gaccggcgag tcgcagggct actacgcaga cttcgccgag
     1741 gctcccttcg ccgccctcgc caaggcgctg accggcggct acttccacga cggcacctac
     1801 tccagcttcc ggggccggca ccacggccgg ccgctggacc ggacgcgggt ggccgggcac
     1861 cggctgctcg gctacagcca gacccatgac caggtcggca accgcgccca gggcgaccgg
     1921 ctctccgccc ggctctcccc ggggctgctg gcctgcgcgg cgacgctcac gctgacctcg
     1981 ccgttcacgc cgatgctgtt catgggcgag gagtgggcgg ccggcacgcc ctggcagttc
     2041 ttcaccgacc acaccgatcc ggagctggcc gaggcggtac ggcggggtcg gcggcgggag
     2101 ttcgcggcgc acggctgggc cgaggaggac gtaccggacc cgcaggaccc ggcgacgcgg
     2161 gaccgctccg tcctggactg gtcggaaccg gaacgcgagc accacgcgcg cgtgctcgcc
     2221 tggtaccggc ggctgatcgc gctccggcac gagcagcccg acctcaccga ccccgacctg
     2281 gccgacacga gggtggcgta cgacgaggag tcccgctggc tcgccttccg gcgcggtgac
     2341 gtacgcgtgg cggtgaacct cggcaaggaa ccggcggcga tccccctggg cacccgcccc
     2401 gcgctggtcc tcgcggcctg ggacccggtc gaccccccgg gccccgacgg cctcctccac
     2461 gtccccgggg agtcctgcgt gatcctgagc cagccctgag cggaggcgaa gaaaggcccc
     2521 acaggctcct gacttccggg gcggcacggc agccccctgt ccccccgggg ggccgatgcg
     2581 ctgtgggtgg gcggcatccc gatgtccacg acggccacgt tcggccggtg ctcgtccact
     2641 gcggcgagca gctcgggtgc cgtcccggag gtggccacca cctcgcatcc gcgggccccg
     2701 ggcagttcga ccatgccgtc acggagaacg acggagtcct cggccagtac cacacgcggc
     2761 tgcctgtcgg tcacggcgcc atgatcgggc acgccgacgc ggcccagggc ctgtccggcg
     2821 gatcaggtcg caggacatcg acggcgcgcc tcatcagagc aggtgagtgg gggcgaaggg
     2881 ggtgccctcg cgtctgcgac aggatccgcc gcaccggccc tacggctcct gctcgtcctc
     2941 cttgaagtcc gtcaggcgct ccagcaggat cggctcccag gcgcgctcca gctgggtgcg
     3001 caggaggggc agggggctgt cgtcgcggcc gtccaggcgg tcggcgaggc tgacgacggt
     3061 gtcacagcgg gccagccaaa ggccgcgcag gcaggggcgg gggccgtagc cggcgagggt
     3121 ggccgcgcgg accgccgcgc cggagccgac cgcgaggacg agcccggcga tgtcctcggc
     3181 ggggtccccg agggccgctc cggtccagtc gaggacgccg cgcaccctgc cgtcggcgct
     3241 gaccaccaga tgctcgccct tgaggtcgtg gtggacgagg acggcggtgc cggactgtgc
     3301 ggcgagctgg gccgcgccgg gcggggtgag ctggtgcagc cgggcggcgt cgaactcgtc
     3361 ggcggtggcg aggcgttcgg ccgcgtgtac ggccatacgg cgcagcgcct ctagggagcg
     3421 cggggcggtg cgtggcacgc cgagcgcctc gacctgccgt acgggtaccg cgcgcagccc
     3481 ggtgagcagc ccggcgaggt cggcctcgcc gacggccgag acgtcgtgtt cctcggcgct
     3541 gccgccgggg atcgccgtgt cgagcgtgta gccgaggccg ggcgcccatt cgccgtgcgc
     3601 cacactggcc gggacggcga cggggaggtg cggccgtgcc aggtcgcgca ggcgcagttc
     3661 gcggcgctgg cgcacggtgg cctcgcggtc gggggcgagc cgcagcacat ggcgggtacc
     3721 gacccaccac gtggagtgct caccgccctc cctcaccggc cgcacatcgg gtcccgcggt
     3781 gccgtcgccg ccctccttga gcagcgaacg gaccagtctg cggacggtgt ccgcggtggg
     3841 tgtcggtgcc tgggtcatgg gtcacgcgtc gccgttccgg gatgtcatcg atgtatgtcg
     3901 acgatgttgt cgatgtcgtc gaagagtcga agaggtgtct cctgggtccg tccgtggtct
     3961 cagtccacta tcaccatctc gcgcgtggtg ttgttgaggc ggcggccgcc gtcctcggtc
     4021 accgtgacga tgtcctcgat acgcaccccg aagcggccgg gcagatagat gccgggctcg
     4081 acggagaagc acataccggg cacgaggggc tgttcctcgc cctcgatcat gtacggcggc
     4141 tcgtgcgtgg tgacgccgat gccgtgcccg gtgcggtgga tgaagtacgc gccgtacccc
     4201 gcgtcggtga tcaccgcgcg ggcggcacgg tcgacctcct ggcaggccgc gccgggccgt
     4261 acggcctgac agccggcctc ctgggcttcg cgcacgatgt cgtgcacccg gcgctcctcg
     4321 tcgctcggct cgcccacgtg gaccgtgcgg gtggtgtcgg agccgtagcc gtccttcagg
     4381 ccgccgaagt ccaggacgac catgtcgccg tgctggatga cgcggtcgcc gacctcgtgg
     4441 tgcggattgg cgccgttggg acccgagccg acgatggtga agtcgacctg ggagtggccg
     4501 aagcggcgca gcaggtcggc taggtcgcgg ccgacgtcgg actcgcggcg gccggcgaag
     4561 ggaaccttcc ggatctcctc gaacgttgcg tcggcagcgg ctccggccgc tgcgaggagt
     4621 tcgagttccg ccgcgtcctt gacggcgcgc agcatgggga gggcgtcggt gagagaggcg
     4681 taggaggtgt cgggcagggc ccgctggaag cccagcaggt gcatggccca ggtgttgtcg
     4741 ctgatgccga accggccgcg gccgtcgagg agggcggcgg tgacggtgta ggggtccttg
     4801 ccgtcggtcc agtcgcgcag ggtgagcgcg gacgcgccgg tcgcgtgctc ggcgtccggg
     4861 gcctccaggg tcggcacgac gagcacgggt tcgtggccgg gggtgaggag cagcacggtg
     4921 agccgttcgg tgaccgcggt gggcgtgtag ccggtgagcc agaccatgtc cggtcccggt
     4981 gccacgagca gccccgcgag accggcgtcg gccgcggagc gcgcggcacg ctccatgcgg
     5041 gccctgtagt cggcggcagt gaagggcgcg ggcgtactac cggtcatccg ggcctccagg
     5101 cgcgagtacg ggtgcgaaaa cgggcgaggg cgtctcgggc agcatcctgc ccgggaggac
     5161 agggtgacgc gagccgatcg ccggcgttcc ccgcaggctg cggtcggcgc ggaagggact
     5221 cggcatgggg ccatcatggc gcgcggggcg gatggtgacc aacgggtttc cgggagtgac
     5281 cggccatcga ttttccgggg tcactcaccg agagggcagg cggtacgggc ccggggtcgg
     5341 caggtatggg ctctcgccgc cccggctcag gtcaccaccc cgggcacgac cgccaactgc
     5401 tggtagccgc caccgctgtg acgcacggtg agaagcaccg gctttccggg ccgggcacgg
     5461 tccacggctc gggcgaggtc ggcggcggat tcgacgcggg cggagccgaa ctgcagcacg
     5521 tcgtccccgc ggaccagacc ggccgcatag ccgggtccgg gcacatgcac gcccacgacc
     5581 agcgcaccca ccttgtcggc gtccacggcc tcgatgccca gggtcgcccc gggcaggtgg
     5641 gccggggcgg ggccgggggt gccggcgggg gtggtgggcg tggccttggc cggcggcgcg
     5701 gccgacgggg cctggcgttg cagctcggcg agcctgctca taccgatcac cgtggcaccg
     5761 acggtaccga tgcccacccc ggacagcacc agcacgccgc cggtgaacag gccgaacagc
     5821 acggtccgca gccgccgtcc gcgccggggc gcggcatgcg ggcggtgggc ggggccgggg
     5881 gtgccggcct ctcgcctgtc ctggccgggc atcggcttgg gacgcagggc agtctgttcc
     5941 atggttcgct cgcctccggc tggtgctcta cccggggcgc cgggctgcca cgagacacga
     6001 aagagtgaga ctggccggaa agtggcggag ggtagtcatc acccccaggg gcgagcacac
     6061 aggacacgcc tcacgctccg gacctctccg ggccctctcc ggaccgctca gaaccactca
     6121 ggaccgccgc gcggcacacg gctcgcacgc atcgccccac tcaccccgcg ccgctcaccc
     6181 cgctcaccca ctcaccccac tcgccccgct cccaccagcc tccgcaccac cccctccgcc
     6241 gatcccccgg gacggccgcc gtggatgagt tccgtgcggt ggacgacccg gggtgcggtg
     6301 agcgggacgg cggccgtgcc gggtacggcg gtggcaacgc gccggggcag cagggtgagg
     6361 ccgtgtccgg cggcggcgag ggcggtgagg gtgtgcagat ccgtgccctc gtagcgcagg
     6421 gcggagcgga aggcgccgcc gccggtcgcg gcgcgcagat ggtccagcgg aagcgccgcg
     6481 tcgggcgcgt cgagccagcg agcgtcggcg aggtcgccga ggcgcaggcc ggtccgggca
     6541 gcaagggggt gcccttcggg cagcaggacg ctcacgggtt cctcggcgac gccgtgcgtg
     6601 gtcagcggcg ccacgtcggg caggcgcagc ggatcgctcg gcgcggccag cccgtcgacg
     6661 aggccgaggt cggcggtgcc ggtggcgacg gcggccggga tctcctcgcg ggtgagcacg
     6721 cgcagggtga ctccggccgg cgggagggcg gcgaggacgc cgacgccgag tgcggtcggc
     6781 gtggtggcga gggtcaggcc gtgccggggt gcggcggtca tacggacgac gtcggcgcgg
     6841 gccgcgtcca ggcgcagcag cagtgggccc gcgtgctcca gcaaccgctc gccggccgcg
     6901 gtgggcacga ccggccgccg ggtcagcagg ggcgcgccca ggtcctgttc gagcgcggcg
     6961 atgtgctggg agacggccga ctgggtgtag cccagcttgc gggcggcctc cgagaaggag
     7021 gcgaggcgcg ccacggtgac gaaggtacgc agcagatgcg ggtccatgtg tccagcatcc
     7081 cagctccatc agcatcgctt atcgaaggtg cagaaatcat cgttggacgt gaacgagcgt
     7141 cggcccgaaa aatgaggtcc atgaacacca ccgcaaccct cgccctcgtc ggcgaccgct
     7201 cccccgacgt ggtctcgcac acgcgcgtgc cgctcctgct ggaggctctg gccgaacgcg
     7261 accggctggt cctggacgcc tactggattc cctccgagga ggcggaggcc gagggcgcgg
     7321 tgcgcgggtt cgacgctgtg tgggtgctgc cgggcagccc ctaccgcagt gaggcggggg
     7381 tcctcgcggc cgtgcgcacc gcgcgcgagg agggcattcc gttcctgggt acgtgcggcg
     7441 gcttccagca cgcgctgctg gagtacgccc gcaacgtgtg cggtctgacc ggtgtcgcac
     7501 acgccgagaa cgacccggag gccacggacc cgctcatcga gccgctggcc tgctcgctgg
     7561 tgggccatga ggccgcggtg acgatcgagc cgggctcact ggcggagtcg gtgatcggct
     7621 cggcacgcac ggtcgagcgg tacttctgcg cctacggccc ctcccgccac ctggacacgc
     7681 tccgcgccca tggtctgcgg ttctccgggc acgacgagga cggtcacccc cgggtcgccg
     7741 aactgcccgg gcatcccttc ttcctggcgt ccctgttcca gccggagctg gccggcgacg
     7801 gctcgcgccc gcacccgatg atccgggcac tggcgcgggc cgcggtcgag cacgcgtcgt
     7861 ccaggatcgc cccgccggcg tgactcccac cggcccgggg ccgaccgccc tgcggtccgc
     7921 cgccctgcag caccgggctg tccggggcag gcgtgaccgt caccgtgcgc cggccgctcg
     7981 gccccggggc cgtgtctcag cccatatgcc cctcgccatg accgccgtgc cctccgtgtc
     8041 cggcgccgtg gtcgaacttc atggcctcgg ccggcatgac gacgaacggc cgcatcatgc
     8101 ccatgtcctc gtgctccagc agacggcagt ggtacatgaa ccggccgtac gccccgtcga
     8161 agcggcccat gacccgcagc atctgactgc cgggcacccg gaagacgtcc ttgttgcccc
     8221 gttcgttggg tgcgagcggg atcacccggt cggcgtcgta gcgcagtggc gtacgggtgc
     8281 cgcctagggc cgggtcgaag cccgagacgt cgtaggcgtc ccggccgagc agctggaagt
     8341 cggccaggtg gatgtgcatg gggtggacga tgggcgcgag gttgaggaag ctccactgtt
     8401 cgtagccgcc ctcggcgatg gtgaagccga gtccgtcgtt gaacgtccgg gaggtgcgcc
     8461 ggtatgtctt cgtggtgccg tcgagcccgg tgacctgcac gatgccgtcg gccgggagcc
     8521 gcaggccgct cgggtcctcg acctcggtca gctcccagat ctccgggtgg ccgccggcgc
     8581 ccttggtggc gggcggggtg agcaggacca tgcggtggcc gtgcggcagg tcgtgggtga
     8641 ggcggcggaa ggagccggag aggacctcgg gcagttcgaa gatgtcctcc tcgcccgtct
     8701 cgccgacccg gaactccagg actgccgggt agcgcacgtc accggccggg tccggcacgc
     8761 ccgccggctg gttggggccc ttgttcacca gccgcagggt gcggcccgcc agggcacgga
     8821 agtcgaccag caggtcgaag cgctcggccg gcgcggcggt cagcgtgggc agctccccgt
     8881 cgaagccgac cggcaccggg cgcggcagca gcccgccgtc gctgccgatc tggtacacga
     8941 cgcccggcac cggattgccg tcctcgtcga tcagcacgag ctggaagatg cgtgcgttcg
     9001 aggcgttgag caggcggaag cggtaccagg cggcgtccac ctcggcgtac ggccagatgc
     9061 ggccgttgac cgtggtgtac gggccggtga agggaacgga gaccggcttc ccggtctccg
     9121 ggttgctctg ctggacgatc accgtcttgt gcagcagccg gccgttgaga cggccgtcct
     9181 cgtcggtgtc gaggttgcgg tcggcgagca gcagcggtat ctcccgctcc ccggacggca
     9241 gatgaagggc gtcctcctcg tcgtcacgca ggaggtaggt gccgtacagg cccgtcatca
     9301 cgttccaccg cgtgatgttc atggcgtggt cgtgatacca ccactgcacc gcctggtggt
     9361 cgttcggata ctccgacagc tgggcgtcgc cgtggccgac ggcgttgtcc gcccagccgt
     9421 cattgccacc accggtctgg gcgccgtgca gatgggtcac cgtccaggcg ggcagggcgg
     9481 cgacgtcctt gtccggctcg acgccctcgc ggcccggctc ggtcgaggcg ggcggggtgc
     9541 cgggcgcacg ggcgggcacc tcgacggagg tgaccgggta ctcggcgtcc ttcggtatgc
     9601 ggttggtcca ggcgatgcgg acgcgctgtc cgcgccgcac ctcgatggtc gggccgggca
     9661 cctggccgtc gtacccccac atcagggtcg gtggcagctg cgggtggagg cgcacccagg
     9721 tcgggcgcac ggcgatctcg gtctcgcgcg ggacgtcgtc cgcagcgggg cacaggacgg
     9781 gcgggacggt caacggcgcc atgtacggcg ccagttcgtc caccgcctgc tcctgctccc
     9841 ccgtctgcct ggtcccttcg gtgagcctgc cgatggtctc ggtcaaggtc gaacaccccc
     9901 gtgtgttcgc ggtctgttgt tccccttact ccacaagact cccgagggct caccgaagtt
     9961 cccagaatgc ccggttccgt acgcgaagat tccgcgactc tcagccgaac gacagggccg
    10021 gcacggcggg cgcgcggtcg ggcacgaagc cgtgcgagcg gcggccgagc cactcggcct
    10081 tgtagcggtc gacctcacgg tgccagttca ggattccggc gagccagttc tgcaggtcga
    10141 gtacgtagcc gtccatggcc gcgcgtccct cctccgacag cccgaaatcg tcgtacagca
    10201 cgggaagttc ttgcgcgatg acgtgctcga actgctgcat ccgctgggtc atcaggtcgt
    10261 gtacgacgcc gagcgcggcg gggtagtcca cgccgaagaa gttctgtacg acgaggatgg
    10321 cgttgtggat ctcgccctcg tactcgatct ccttctggta tgagaagacg tcgttgatga
    10381 ggcaggcgta gtcgatcgcg gcgttctcca gggccctgac cgggccgctg cggtacacct
    10441 ccggtgggat cgcggggccg tggcccatcc ggcacaggat cagggtgagg tcggagccga
    10501 aggtggcgcg ccgcatctcc aggtagtcga ccgggtcggg gattcggttc tgcagctggt
    10561 tggacagctc ccacacccag ctctcggtca tcacgtccac ggcgtccttg agggtctgcc
    10621 gctgctcggt ggtcatcccg gcggtcgtgc gcgcccacag atcgaccagc ccgcgttcca
    10681 tcgcgtcggc ggggacgacg gacggctcgc cctcgaccgg catgcacgcc gacagccggg
    10741 ccgtgctcag ccgcgcgccg gccaggtccc ggcggcggcc gtagaccagc gggtagtagt
    10801 cgtcggcgta cgtcccccag gcgagccact gggcgctgag gtcgagggcc tcgggggtgg
    10861 cgtcggggtc gagtcccgcg gagcacagcg cgaggtcgta ggcggcgagc ttgtcctcgt
    10921 cccagacgcc ctcctccaag atgcccatgc ggtgcgacca ggccaggaga ttgcgccggg
    10981 cgccgtccag atgggggctc aggcccagtt cgtacggcat gtggaactcg ggcaggatcg
    11041 aggggccgac cttctggtag ggcacgtggc cgtaggcgcg caggcgttcc cgggcggcgg
    11101 tggcgagcag cgcggcgacg tcggcggccg aggtgccggg gccggtcagg agctgccagg
    11161 gcgcgtcggg gcgcgcgccc ttgttcatat agcggctgga ccgcatgtgc cattcgtggc
    11221 cgccggactg ccagtcctgc agccccttgg tgtaggcggc gaccgcggcg gtctgctccg
    11281 gggtgagacc tttctccagg gccacggcgg ggacttcggt gagcgcggtg tgctcgaact
    11341 ggtgcaggcg tgaggtgagg atgtcgttga cggtctcggc ggcctcttgg gtcgtacagc
    11401 cgaagaacgt ctccaggacg agcacgccgt tgctgttctc accctcgtcc tcgacctcgc
    11461 gctggtacga gaacaggtcg ttacgcaggt ggacggcgtc ggagaaggtc tccatgagga
    11521 cgcgcagggg ccgggtgccg gcgacggcgg cgggcacctc ggcggtcgcg tactccacga
    11581 gtcccgacga ccagggggcg ccgcccacct tccggcgcat ctcgatgtac tcgacggggt
    11641 tggcgatccg cccctcgttc atgttcgaca gttcccacat cgactcgttg agcagatgct
    11701 cggtggccac ggagaagcgg cggcgccagt ccacggacat cgacgggacc gtgcgcgccc
    11761 acaggtcctt caggcccgcc tcgacggggt tctccggctc gggtacgggg gtggccgggt
    11821 cgagcggcat gaacagcggc aggcggtcca ggtgggcctt tccggcggcg cggtcctggg
    11881 tgcgcttgaa catgtcgagg aagtggtcgt cgaagaagaa cacccacacg taccagtcgg
    11941 tgatcagcga gagagcggtt ccgtcgcagt cggggtgggt gtaggagcac aggagcccgt
    12001 agtcgtgcgc ctccaggtcg gcctgctccc agatcccgga gccttcgagc atgcccatct
    12061 cgcgcgccca ctcggtggag tgggcacggg cctcgtcgag gtgcgggttg agccgcgcgg
    12121 gatacggcat gtagaagtgc gggagttcga acggctgcgt catggccggg ccctacccgc
    12181 gcccccagac ggccatccgc cacgcggcac atgatcacac catcgcgtga accgcccccg
    12241 aagcagggaa cttccgcgtc gttcacgggc gttcagggcc ccgcgcgcgc tcttgccgtg
    12301 tcctcgcgcg cgggccacgg taggcgcatg acctcctttg tgctgcccca tgaggtgcac
    12361 ggcgacggcg cccacaaggt gttcgccgtg cacggctggt tcgccgaccg gtccgcctac
    12421 gccgccgtcc tgccggacct cgaccgcacc gccttcacct acgccctggt cgaccttcgc
    12481 ggctacggcg aggcccagga cgcggtgggc gcgtacacga cggccgaggc ggccgcggac
    12541 ctggtggagc tggccgaccg gctgggctgg cagcggttct cggtgctcgg gcactccatg
    12601 ggcggcgcgg tggcacagcg gctggcggcc gtcgtcccgc accggttgcg ccggatcgtc
    12661 ggcgtctccc cggtgcccgc ctcgggcgtc ccgctggccg gcgagcaggc cgcgctgttc
    12721 tccgacgccg cgcacaagcc ggagaaccgg cgcgcgatcc tcgacctcac caccggcggc
    12781 cggcgtcccg cggcctggct ggaccggatg gtcgcccgct cgctggagcg cagcgacgcg
    12841 aaggcgtgcc gcgcctggct ggactcatgg gcgggcgacg acttccacgc cgacgtcgag
    12901 ggcagcgagg tgcctgccct ggccgtggcc ggcggactcg acccggcgct ctcgccggaa
    12961 gtcatgcggc agacctggct gtcctggtat ccgcgggcgg aactcgtgac actgccgttc
    13021 gccggacact acgccatgga cgagtgcccg ctggaactga tccgcgtggt cgaggacttc
    13081 ctgcgagccg acgccgactc cggcgcccac accgggcgta cgacggacac cgggaccgac
    13141 acaggcatca cggccgacac gggcaccacg gccgacacgg gcaccacggc cgacacgggc
    13201 accacggccg attcgggcac cgcggccgcg acagacgccg cgagcccctt ggccgcggcc
    13261 ggcgagagcg agccggtgtg agggtgcgtg aggccccgcc cgtgcccgac gtgttcgacc
    13321 cgcgccggta cgccgccggt gtgccccacg acgactaccg cgtgctgcgc gaccaccatc
    13381 ccgtcgcctg gcaggaggag ccggaggtgc tgggctggcc ggccgggccg gggttctggg
    13441 cggtgacccg gcacgcggac gtcgtacggg tgctgaagga cgcgacgacg tactcctccc
    13501 acctcggcgc gacccagatc cgcgacccgg acccggcgga tctgccgttc atccggagca
    13561 tgatgctcaa tcaggatccg ccgcagcatg ggtggttgcg gcggttggtg agccgggcgt
    13621 tcacccccgg ccgggtcgac cggttcgcgg cgttcgcccg ggagcgggcg cgcaccctgc
    13681 tcgccggggc gctgcagcgg gcgcgggaag gggacggcac ggtcgacctg gtggactgcg
    13741 tcaccgacga gtacgcgctg ctcaatctgg cggacctgct gggcgtcccg gagagcgacc
    13801 ggcggcggct gctgcactgg acgcggcggg tcatcggcta ccaggacccg gacgaggccg
    13861 gccccccggt gctggacggc acgggcaagc cggtcgatcc gcgctccccg gcgatgctgg
    13921 aggacatgtt cgactacgcg cgccggctgg ccgcgtacaa acggcgtcac ccggccgacg
    13981 acgtcatgac caccctcgcc ggcgacgccg aactcaccgg cgccgagctg gagatgttct
    14041 tcttcctgct cacggtcgcg ggcaacgaca ccgtacgcag cgcggccccc ggcggactac
    14101 tggcgctgac ggaacacccg gagtcgtacg cgtcgttgcg cgccggaaag atcgaaatgc
    14161 cctcagccat agaggagttg ctgcgctggc atccacccgt gctgaccttc cgcaggactg
    14221 ccgcgcggga caccgagctg gcggggcagc ggatccgggc cggtgacaag gtcgtggtct
    14281 tccacgcctc ggccaaccgg gacgagcggg ccttcgccga tcccgcccgg ctcgacctca
    14341 cccgttcccc caacccgcat gtgtccttcg gcgacggccc gcatgtatgc ctgggcgccc
    14401 acttcgcacg gctgcaacta cggctgctct acgaggaggt gttgcgcgtg ctcccggagc
    14461 cgcggctcgc cgcaccgccg gagcggctgg tgtcgaactt catcaacggc atcaagacac
    14521 tgtctttcga catcacttga ggtcgacctg gatcagcgcg tgcgtgccgc tggtgcgcca
    14581 gcgctgctcc tcgaccgcca ccggagcggc ctcggtcggc gaccacagcc ggtcgcccac
    14641 cagacgccgg tagttgaggt cacccttggg gacggtcagc gtggccgcgg cgaactcggc
    14701 gcacaggtcg tccggcatcc gttcgtacgg cagcggggcg caggagaagg ggtgagcgcg
    14761 cacggcgagg cggccgtccg ccatggccgg ccagagcacg cgcgcgtggt caccggcagt
    14821 gcccggccgc cgtccggagc cggtgcggcg cgtcgacgag gtcagcggac gtggcatcgg
    14881 agacgtagta cgggtgcggc ttgacgtgca gcaccgcacg cgcgcccccc ggcgaggagg
    14941 tgggcgatca gcggcagatc cgggacgagt gcgcggcccg cgttgtccgc gaccaggacg
    15001 agcgtggccg agccatcggg cggcagcagc gaccacaggg cctcgctgtc gtcggcgacc
    15061 agtgaggggg ccgcttcccg ggcctcggcg ccctcggcgg agagccggaa gccgaggtcg
    15121 gcgcggttac cccacagcga gccgtgcagc agggcacacg cctgcccctc ctccggcagg
    15181 gcagggcgtc cagcgcggcc agttccgcgt cggtctccgg tgcgtggagc tcggcgcgct
    15241 tgaacgggcg gaaggggtcg ataccccgca gggcgccggg gtcgaaccag ccgaccccgt
    15301 cgagcagcca gcggtagaag tagctctcgg accacagccg gcggtcggac cacagccggc
    15361 ggcacgtcgc accacgagcg tccaatgctt ccctgggccg tacgggaagg cgacccgcac
    15421 ctgccggatg atcgcggggt gcctccccta ctcctaaagg gcgcgggagg tacccccacg
    15481 gccggcacgc tgtgcgggaa cgagccgggt tcgttgccca aaatcacgga tgcgaacggg
    15541 gcgtggggca tgctcgtcac cgtatcgcgc gcctcaggcg gttctgatct cccgctccag
    15601 ctgcgtggcg agcgtgacgt agcgggggcg gcggtgcacc gggaccaggc cccggatcag
    15661 caggtgccac atctcggcga tccggcgcgg aagccgcccg accggttcga gcgaacggcc
    15721 ggcgacccgg gtgccgacga agaaggagac gagggagtgc gcgacgacgc cgacatcgag
    15781 atcgctgtgc acatcggact ccctgacggc cgcggtgaac ttgcgggtcg cgaactccag
    15841 ccattccgtg aacgggtgcc tgagcggcgg ccgtacggcg atgtcggcgg tggcgagacg
    15901 gagcgcggcg cggggcaccg ggtcctccac ggcgagccgg gcgaccccga acgtggtgcg
    15961 catcagggcc tccagcgagg agtagccgcg gctctcgacc tcggcgacga gctgtttccc
    16021 cgccctggcg ttgagttcga ggatggcctg ggcgagatcc tccttggcgg cgaagtggaa
    16081 atacagcgcg cccttggtga ccttcgcgtg tgcgacgatg tcgctcaggc tggtggattc
    16141 gtagccgtgc cggtcgaaca gatcggcggc ggccgtgatg atcgttgccc gggtctgctc
    16201 ggcgcgtaac tgcctcgcca tccttgggac ccctcctcgc agctgaaacg aacgggacat
    16261 gcggtttgtt ttaacccctt gcacacgata actcaccgag cggcagcggg agtccggagt
    16321 gcgggccggt gatacggcac gtgccacctg cggatccgac ggcgaacggc ccctcggcgg
    16381 tccgtgaacg gacgagacaa gaacggttcc ccccttgttg cacgactgtt gcccggctgt
    16441 tctcggcagt cgcggggcga cgggcgccgg atccatgatc gccaccctat gaggccgaac
    16501 gccggctcct caacggggcc tcgaagcagg cgtgaaacat cccaaccggt cggtgctttc
    16561 gcgcccctgg atccgcaatg cgccgggccg gctgaacgca ccgcttgcct gtgtcgtatt
    16621 ggacgccgaa gacaccgttc ccgcgcccac cgcggagatg ccccgatgct tcggacgacc
    16681 cgggcgaccc ggaacccgga cgacccggat ggctcggatg acccgggcga ccgcccgcct
    16741 gagcgtccca gtggccgtcg cggcgccccc gctcccgctc ctgccgtggg cggcggggtc
    16801 cgcccaggcg cacggagccc ccacggcccc ggccagccgg gtctacgcct gctcccccga
    16861 gggcggcgag accgctcgcc cggcggcctg cagggcagcg gtcgcggcga acggcgcccc
    16921 gttcacggtg tgggacaacc tccgcgtggc aggggtgaac ggtcacgacc ggcaggtgat
    16981 tccggacggc cggctgtgca gcggcgatct gccggcgtac cggggcctgg acctgcggcg
    17041 ggactggccg gcgacgcggc tcacgcctgg cagcaggctg acgatgacct acgcctcgac
    17101 gatcgcacac acgggcacgt tccggctgta tctgaccaag cccggttacg acccggcgaa
    17161 accgctcacg tggcccgatc tgccggagcg gccgttcacc caggtcaccg atccgccact
    17221 gcggaagggg gcataccaca tcggcgcgcg aatgccgacg gaccggacgg gccgtcagat
    17281 tctttacacc gtctggcaga accgcagcac accggagacc tgctactcgc gttctgatgt
    17341 ggtctttccg gagaaggggg agactcccgc cgctgataag cctgttgcgg gctcgggagt
    17401 ctccacgcac atgccggcgg gcggcgccgc cgcggtgctg gtgtgcaccg ggggcgccgc
    17461 cctcgccgta cgactacgac ggcgttgaac tcgcctaaat caagcctcag ttgacgtaga
    17521 cccgggcgcc gccgtccgtc acgggcgcgt acttggcggt gaagtagccg ctggcgaaac
    17581 acagcgacga accggaggac ttggtgaact gctggctggt gaagctgatg ctgctgtcgg
    17641 tgttgtcggc cttcccggaa agggacggcg cctggtagac gcaggtgatg gtgcccagca
    17701 gggtcttcag cttgaccgtg gtctggatgg tcgagccggt ggccggggag acggtgaggg
    17761 tgccgtcgga gccgaccgtc gccgtgtagg gcaggttgtc gacggtgatg ctgctgacgc
    17821 cggtgacacc ggggacgttg ctggtgcagg agcttgcgtc gaaggtgtgc ccggtgacgg
    17881 actcggtggc cgtgccgggg gcggtcgggt tcccggtgac cttggcggtg aactgggagg
    17941 acgtgcaggt gacaccgctg gtgccggtcg cactggagta gaacgtcgcg gacgtgccgg
    18001 acgccagggg cgcggtgagg gtgtcgccgg tcgccgcggc ggtgccgccc gcgctcccgg
    18061 tggtgagtac ggcgctgccg tcggcggagg cgggggcggc cagcgcgagg gcgagtgcgg
    18121 tggcggtgcc ggcgagggcg aggaggggtc gcgtacgcat gcgggtgcct ctttcctggg
    18181 tggggtccgg atgaggtggg gtggggggtg gggacagggg ctgggggtgg acgatgccgt
    18241 gcggcatcac gtggtgacgc gtgatggcac gtggtgatac ccggtggtgt gtgcggtgcc
    18301 gccgacgcag ggccgttgcg ccttctccgt acgcgacggg ccggcgccgg cggcgatccg
    18361 ggcacctgcc gaaggcctcg gggggagggc attcggcagg cccggcgggc ggtcgggcac
    18421 ggccaggggg aagggccgtg cgcagccgcg gtggggggaa cgctttctgt gcaccgtggt
    18481 gagcggtcgg cgtgacaggg ccgggaaacg cggccggtgc cgctcggcgg atccggcgcc
    18541 acggatccgt gaagcagggc aagttgtaga cctgatcaac catcaacgtc aaggtgtaac
    18601 aagggagttg gcgagtctcg gtcgcacccc acgcacatcc gacacccttt tttcacatct
    18661 cccttgaccc tccgaagtaa ccggcggtaa cttcctcgga aggctactgc cgcgtaacga
    18721 gaaagccctt gctccgccgg ggtgcgagga ggcgtacgcg acagtcgctg tccgcgccag
    18781 gacaacgttg ccgctgaagc ccaacccgca ttgatccatg cccatgggag cagacatggc
    18841 ctcgtccccg gacgtcccgt ccgccggcaa cacccccgag aacccgggaa acggttcacc
    18901 gtccgaagcg accgagcccg tccgggcctc cgcggcaccg gagacggacg cggcgccgcc
    18961 gaccgccggg accgccggcg gcggtgagag gcggggccgg gtccgggcgc gccgggccgc
    19021 ggtgatggcg gtgcccgcca ccctcgtcgt cgccggactc gcggtcctca ccgcgcaggg
    19081 ggcgctgggt gtgcagttcg cgatctccgg catgccgttc acggtcaccg cgacggaact
    19141 gaacggaacc ggtttcgagc agttcggcgg cctcgacaac atggcggacg gcagcccgaa
    19201 cgccggggac agcggcgggc aggagctcgt cgtcacctcc gctatcaaga acgccacact
    19261 caccaagctg tgccagagcg tcgacctcgg cggcacgaac ctgctgatca ccgcgggcag
    19321 cggtgccgac aaggtgaccg cgagcgatct gacgaccgac tccacgcagc tgtccggcga
    19381 cgcggcgttc aacaacatcg agatcggcaa cgacgccagc acgctgacca aggcgggcgt
    19441 gaagggcccg atcggcgtct tcagccagca ggccgacacc gtgcgcatcg ccaacctgcg
    19501 gcagaccaac tatgcgacga cggcaggggt gttcaagctc cccggtctca agctccgctt
    19561 cagcggctcg ggttgctgag agtgtccgag ctgtccgacc gtccacgtga gggagcgcgg
    19621 gccgcgttcc gtaggtggcg ggcccgccgg ccgttctggg gcgggctgct gctcgccctg
    19681 gccggcggcg agatcctgct gaccgagaag gcctcgctga aggtcgtgat gcacatcggc
    19741 atgcaggggc tggccgggta tctgctgccg tcgctgatgg cgctgctggg tctgctggtc
    19801 ctcttcaacc ccgcgcagcg gctcttctac tccatcaccg gcgtcctggt ctccctgggc
    19861 acctggatga cctccaacct gggcggcttc ttcatcggcc tcctgctcgg catcacgggc
    19921 agctgcctca ccttcggctg ggtccccgac caggagccgc gcatcagccg ccgcgaacgc
    19981 cgcaagcagg ctcgggcgac ggtgggcggc cacgtcgttg gcaccctccc cgagggggcc
    20041 acggggaatc agtccgggtc ggcgggaact cctcgggcgt ctcgttagtt tctacggtgt
    20101 tgtagaagtt gccgtcggcg tgtgggggaa gccgccggcc gttgatatga ggagtgcccg
    20161 tggccctgtg ggaccgcgtc aaggagtcgg cgtcgcagat gcagacccag ttgacggcga
    20221 agaagaacga cctgaagagc ggtgcgttcc gcgacgcgag catggcgatg tgcgcgctcg
    20281 tggccgccgc ggacgggacc gtcgacccgt cggagcggca gcgggtggcc cagctcatcg
    20341 cgacgaacga ggtgctgcag aacttcccgg cggacgacct gcggcgccgc ttcgaggaga
    20401 atctgaacaa gctgacgacc gacttcgcct tcggcaaggt gagcgtgctg caggagatcg
    20461 ccaaggcgaa gaagaagccg gccgaggcgc gggccgtggt ccagatcggc atcgtgatcg
    20521 gcggcgcgga cggcgacttc gacaagacgg agcaggccgt ggtgcgcgag gcgtgctaca
    20581 cgctggacct gactccgcac gagttcgacc tctgagcccg ccgcaccgcg cgaggatggg
    20641 ggcatgctcg acgctctcga ccgtgctctc atccacgcgc tgcacctgga cggccgggtg
    20701 ccgttcagca ggatcgccga ggtactcggg gtctcggcgc agaccgtggc ccgccggtac
    20761 cgccgactgc gtgcggaggc cgggctgcgt gtggtgggcc tcgccgaccc ggaccgggcg
    20821 ggccgcgcac agtggttggt ccggctgacg gctacggcac gctcggcgca ggacatcgcc
    20881 ggggcgctgg tacggcggcc ggacacgtcc tgggtgaagc tgacttcggg aggcacggag
    20941 atcacggccg tgatccatgc cgcggccgag gacgcctccc ccggctccct cctgctgcac
    21001 gacatcccgc gcaccggcgg cattaccgcc gtctccgcgc acctcctcct ccacacctac
    21061 ctgggcggac ccgccaactg gcgacgcagc gcccaggctc tcgacgagga gcagcagcgg
    21121 gcgttggagt accggggcga cgccgtggcc ggggaagggg atcgggaagc aggtgacggt
    21181 gtacgtcaac ccggcccggg ggacggcgag ttgttcgctg cgctggagcg ggacgggcgg
    21241 gccgggcagg gggagttggc ccgggctacc ggctggtcgc ccacgaccgt ggcccggagg
    21301 ctggccgaac tgcgcgcggc gggcgcgctg ttcttcgacg tggaagtgga cgcggggctc
    21361 ttcggcgtcc gtgcccgggc tctgctgtgg ctgtcggtgc gtccggcgga cctggagcag
    21421 gtcgcgctgg ccctggcgga tcatgacgag ctggccttcg tggccgcgac caccgggcga
    21481 accaacctgg tcgcccaggc cctgtgccgc gacccggccg acctgcaccg ctatctcacg
    21541 cggcggctcg gctcgctgcg ggagatcgac gcgctggaga ccagcccggt gctgcgtacg
    21601 ctcaagtcgg cgagccccgt gcgggtggcc gggccgcgca cgcccaccca ccgggccggt
    21661 tgagaccgta cgcggctgcg ggcgcgttgt ggctggtcgc ccccccgagt tctcggcttc
    21721 gcccgaacca gggggacccc catcgcggcg gagccgcaca tgcaacacag tcccgcgccc
    21781 cctagggagc agtccgccgc accccttgga gaaccgcagg cgccgcacgc ccaagacacg
    21841 ccgccgccta ccctccctcc cccgtcccga ccctgccgct cgccacccag gccacggtca
    21901 gcagtgccgc cgccacccag caggtggcct ggggcgcgtg cgcacctgaa ccggacaggt
    21961 acacgctgcc gagcaccgcc acccccagcg tggcccccag ttgctgtacc gcgttgagga
    22021 ggcccgccgc ggagccgacc tcgtgtgggc gcagaggtcg cagggcgagg gtgaagaagg
    22081 cgggagtgaa caggccggcg ccgaggccga tgagggcgag ggcgggcagc agcgcgaccg
    22141 ggaagtggcc cggctcggtc gtc
//
