LOCUS       NZ_CM002273            11368 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces sp. PVA_94-07 strain PVA 94-07 chromosome, whole genome
            shotgun sequence.
ACCESSION   NZ_CM002273
VERSION     NZ_CM002273.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. PVA_94-07
  ORGANISM  Streptomyces sp. PVA_94-07
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Draft sequence of Streptomyces sp. PVA 94-07, a marine actinomycete
            isolated from the sponge Phakellia ventilabrum collected in the
            Trondheim fjord (Norway)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Assembly Name                     :: PVA94-07.23
            Genome Coverage                   :: 158.81x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495755.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:29:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,173
            CDSs (total)                      :: 6,079
            Genes (coding)                    :: 5,859
            CDSs (with protein)               :: 5,859
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 220
            CDSs (without protein)            :: 220
            Pseudo Genes (ambiguous residues) :: 0 of 220
            Pseudo Genes (frameshifted)       :: 97 of 220
            Pseudo Genes (incomplete)         :: 166 of 220
            Pseudo Genes (internal stop)      :: 15 of 220
            Pseudo Genes (multiple problems)  :: 55 of 220
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:06:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6542194
            Orig. end                         :: 6553562
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002273.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Department of Biotechnology,
            Norwegian University of Science and Technology, 7491 Trondheim,
            Norway.
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="25"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            275..1330
                     /locus_tag="B590_RS28395"
                     /old_locus_tag="B590_28769"
     CDS             275..1330
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894130.1"
                     /locus_tag="B590_RS28395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28769"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_037788141.1"
                     /transl_table=11
                     /translation="MSAARTAAPVLRRGWTGTGLKAAVLMVLALAAGAAGLVAGPAVTT
                     ADVAEVLAGGGDPLARHIVLNLRLPRALVAVTAGACLALAGLVLQSALRNPLAGPEVTG
                     VTPGAVLGAVTATGLGLAGWQSPTAVLVAACLGGCAGAGLLWLLAGRERGDPEQTAVHG
                     VLVSAVLTGATAVVLLIAPGELGSVVQWLVGSTEGRVWRHWELLWPWALCWGAVAWLLA
                     GPLTLMRCGDEQAAALGLDTGRARAAALACAVALTAGAVSAVGALGFVGLLVPHVALAV
                     FGADLRATLPGAALLGAVVVGGADAGAQLLSRALAQALDADRLTVPVGALTTCAGAALL
                     LIVARRRADLR"
     misc_feature    1394..1409
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            1452..2288
                     /locus_tag="B590_RS28400"
                     /old_locus_tag="B590_28774"
     CDS             1452..2288
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="B590_RS28400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28774"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023420771.1"
                     /transl_table=11
                     /translation="MDHREPGAVVAEGLRFGYPGREVLRGVDLRIGAGELVALVGLNGC
                     GKSTFLRLAAGLLRPDGGRVLLDGEEVARLSRRGAARRVALLHQSAPPVPGLTVRQLVR
                     QGRYAARGPLGMLRDGDDAVSARALADAGVADWAGRPVDALSGGERQRVRLAMALAQDT
                     RTLLLDEPTTYLDLRHQLEVLQTVVRLRAERGLTVVMVVHDLNHAARFADRIVALRDGR
                     VAADGKPADIVTPALLADVLGVEGRVAPDERGGWPVCYPDHPLEAARPLRTENHIH"
     gene            2357..2491
                     /gene="amiA"
                     /locus_tag="B590_RS33785"
                     /old_locus_tag="B590_28779"
     CDS             2357..2491
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="B590_RS33785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28779"
                     /product="streptamidine family RiPP"
                     /protein_id="WP_023420772.1"
                     /transl_table=11
                     /translation="MEHDKVFAPIADPGQLAHLSATHSNALVENPFDDADETGAADDK"
     gene            2634..3478
                     /locus_tag="B590_RS28405"
                     /pseudo=""
     CDS             2634..3478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470988.1"
                     /locus_tag="B590_RS28405"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTSSRLAPGAGIVTVPGGRPAVRTAEGEFLHLDTGAADLAALTRR
                     LVSGEAASDAEVARVAAAFEREGHAVRPAPEEGGRLTGRTVLLLGDARLTGPLARYATA
                     EGALARHATPEHVARLADGEGADASTAVVWCLDEPVPPGLWDVADRLPAHGTAWLRCHR
                     EGAHLWTEPLAAAPGDVTSAHVRLRPSPPPPPTASSPPTGPDTAPPTTARTPARPPPPW
                     SPPSSPPTSSPGPCRARTPGSPRDAGSAASTCATSPSPNTPCCPYRRWPRCPAGGAARH
                     "
     gene            3475..5004
                     /locus_tag="B590_RS28410"
                     /old_locus_tag="B590_28789"
     CDS             3475..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639446.1"
                     /locus_tag="B590_RS28410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28789"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_023420774.1"
                     /transl_table=11
                     /translation="MTPATTRLTTPDGTTLATDLHLPATPGSHPAVLIRTPYDRRAHRA
                     ELRGWAERGFAAVAQDVRGRHGSAGEWHPYRDHEAEDGVATLDWIRAQPWSDGRVVAAG
                     ASYAAYCALAAALSPGAPGPDAVIAAVPALGLTETAREPTGPERLWARLGWWAAHGDRP
                     DSAPDALARTLARDPRLPEHLPLTRIADRLDRPLPSWPALWEDCRRGRLVAHGSAARLP
                     LLAVGGTRDPFAEDTVALWRGWGGPARLLLGPWGHTLTAGTRPGTPGRLDLGALYARWA
                     RAALDGEIGPGRRGVIGLAQSGRWHHLTDSVTRPEGYEVAGAVWRFGAADGLRLLAGAE
                     FTADPDRPVRSDDLTVPRGRTPADRCLLATPPLPRPLDLAGSAEARLTVVADTPRADWA
                     VRVVALDPAGRADPLAFGIVRRDAPPGTPHPVTVPLGTLGRTLAAGTTLRVEIAGHHFP
                     AHARNPHTGEDPVTATRLAASRRTVRTEGSALHLPVAGRPRPVDPVPETCR"
     gene            5001..6368
                     /locus_tag="B590_RS28415"
                     /old_locus_tag="B590_28794"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="B590_RS28415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28794"
                     /product="YcaO-like family protein"
                     /protein_id="WP_023420775.1"
                     /sec_met_domain="YcaO (E-value: 5.2e-43, bitscore: 146.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAALPLDALVDPHCGLVRDVAPVPHPEGAPPRYTAMTAHVADAR
                     RFGAWPADRVSLGTTFGDPAGAWTAAVAEAVERYCGNRLPPPGHPDAPRRATAAQLTAE
                     GHQLYGPDDVPAYAPWQYRRPAFPYAPLTPDTPALWARGTENGRDCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLADAAERALLEVVERDALELWWHLDGPTRGIDPGSVP
                     GLDADLAGCGLEVSIVEMPSEFAPCVAALVHDARRGVHAAGFACRFDPAEAARKAVLEA
                     VHTWVFTLGAEAADGWVHQAVEAGVLARGLYLDHRADRRYLDDCGEEFAAVRDLGAHVQ
                     AWLDPRLAPLARRFTAPALGTVPVAELAHGSRDRLDTALAEGGHRVLTFDLTTEDVAET
                     ALRVARVLVGGLVPNAPAAFGYYGCPRFATAAPARGWRSQPPREPGDFTLAPAPHM"
     gene            6382..7689
                     /locus_tag="B590_RS28420"
                     /old_locus_tag="B590_28799"
     CDS             6382..7689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508299.1"
                     /locus_tag="B590_RS28420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28799"
                     /product="nitroreductase"
                     /protein_id="WP_023420776.1"
                     /transl_table=11
                     /translation="MTTDAILGHALALARSPRTPARATPPPRRPYPWTGTPLALPATAP
                     DPDGPVDLDHLLRHALRARPGTGGRLRPAASAGALHPVRAHLLIGPGCTLPPGRYAYDP
                     EVHRVFRRGPAPHGAAPGMIAVLTATAERTAAHYGHRAWPLLLLDTGHAAAALALAPQG
                     PGVRVSLDADAATLAAAAGLPPADRWQRIRPGTETEHPLAAVQLTPRRTQCTTPALDRW
                     SALPLPDRIRTPTRPPARPCGTGRLLELLGAATGTEPTWHPVRRPDAVTGRALLDRRSA
                     DPAALGHPPDGGTVARILRTAATAWPGGPAWCAAVAAPTPALFAPGHRTADPHRLARGD
                     ARPSLAHWAAGQLWLADTGAVLLAHGCPSDAPAHQVRQDHLAAGFAAGTAHAHAAAEGI
                     AARPVGSWQQADLGAALGETPGRDWVLHGLALGAAR"
     gene            7748..9490
                     /locus_tag="B590_RS28425"
                     /old_locus_tag="B590_28804"
     CDS             7748..9490
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894136.1"
                     /locus_tag="B590_RS28425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28804"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_023420777.1"
                     /transl_table=11
                     /translation="MIPPPELRRAARPAALPLAGATALLALVGATHIGQAVLLALVLAR
                     VARGETAGLPALLAAVAAVVLARALLGRAQRLLAVRAGALVRVRLRDDLLAHLGGTGPG
                     ALAGARAGAVRATLVDGVEGVDAYVSRHLPHLIVTCALPPLLLVAVALVEPYAVAALAP
                     ALLLALAGPRLWDRLLARRGREHWDSYEALAADHLEALQGMAALRAAGAVGRTRARLER
                     RSAALHRATVAKMRVSLADTGLTDLAVQGGTVAAVLVACAAATTGGTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGHLGLSAVDGIAALRHAEGGVPDEGTAADWATPPEVRFENVHF
                     THPGRIRPALAGVAFTAPAGRVTALVGPSGAGKSTLLSLLLRQRDPDSGRVTVGGLDTA
                     AYRLDALRRGIAVVSQDTYLFRATVADNLRLARPAATSAQLHEAARAAGIHEELTRLPD
                     GYDTVIGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDERAEARITRELLAAG
                     RGRTCLLVAHRLEAVRHADHIVVLDHGRVDAAGTHSELLAADGLYARLVAAGRTVTPMQ
                     QEAA"
     gene            9487..11271
                     /locus_tag="B590_RS28430"
                     /old_locus_tag="B590_28809"
     CDS             9487..11271
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470983.1"
                     /locus_tag="B590_RS28430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_28809"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023420778.1"
                     /transl_table=11
                     /translation="MTPPTPPEPPAGPPPHKALRSLLPVLAAHRAMTARTCAAALVDQA
                     ALVVLVTLAAHTVGTAVIDGRPPSAATMALLVALAAVRALATWREMDLSHDLAYRVLAL
                     LRVRVFDGIARSAPARVAGRRSGDLASTALGDVEALEFFYAHALAQLLATGTVFTVSAA
                     LLGTREPWLLALVLPAAALLLALPVLDGRGRAARGARTRTALADLSAETVETVDGLREL
                     LAFGALNRRRARLRAYGRRLARAQRAEQSWEAGAAALRDLLVVAAVIGVVAVAGHSAVE
                     GRLHGAWTPAAMALALGALAPVADAAASLGQAGSLRAAAARVRAAADAPAGAPAPSTPR
                     PLPEGPLGLRLRGVRFGYGGTPVLDGVDLTVRPGETVALVGASGAGKSTCAHLLARYWD
                     PQEGTVTLVPEDGRPPVALRDLGDAELRSAVAVVGQEAPLFHGTLAENLLLAAPDAPPD
                     ALDRAVRACGVDTLAAGLPDGLGTAVGERGATLSGGQRARVALARALVAAPRVLVLDET
                     TAHLDHTGDAELAAALAASAPGRATLVIAHRPATVRRADRVAVLEDGRIVEEGTWEELA
                     SAGGALTRLLSREATATA"
ORIGIN
        1 tcggcttcct cgccccgcac ctggcccggc gactgcggcc cggcgccgac gcggcggggc
       61 tgctcgggta cgcggccgcc tgcggcgccg tcgtcgtggt ctgcgccgac ctgcccgccc
      121 ggctgctgct cgcccccgtc gagaccccgg tcggcgcctg gaccgccctg ttcggggtgc
      181 cggtcggcgt ggccctgctc aaatggcgcg cgcccgcccg cagttcaccg gcccccgcgc
      241 ccggcgaccg ggccgccctg cggaaggccg agcggtgagc gccgcgcgga ccgccgcacc
      301 ggtgctccgg aggggctgga ccggcaccgg gctcaaggcg gccgtcctga tggtcctcgc
      361 cctcgcggcc ggggcggcgg ggctcgtggc cgggcccgcc gtgaccacgg ccgacgtcgc
      421 cgaggtgctc gcgggcggcg gcgatccgct cgcccggcac atcgtgctca acctccgtct
      481 gccgcgcgcc ctggtcgccg tcaccgccgg ggcctgcctc gcgctggccg ggctggtcct
      541 ccagtcggcc ctgcgcaacc cgctggccgg tcccgaggtc accggtgtca ccccgggcgc
      601 ggtgctcggg gcggtcaccg cgaccggact cggcctcgcc ggctggcagt cgcccaccgc
      661 cgtgctggtg gccgcctgcc tcgggggctg cgccggggcc gggctgctct ggctgctcgc
      721 cgggcgagag cggggagacc ccgaacagac cgccgtccac ggcgttctgg tctccgccgt
      781 gctgaccggc gccaccgccg tggtgctgct gatcgccccc ggcgaactcg gcagcgtcgt
      841 gcagtggctg gtcggctcca ccgagggacg cgtctggcgg cactgggaac tcctgtggcc
      901 gtgggccctg tgctggggcg ccgtcgcctg gttgctggcc gggccgctga cgctgatgcg
      961 gtgcggcgac gagcaggccg ccgcgctggg cctcgacacc gggcgggccc gcgccgccgc
     1021 cctggcctgt gcggtggcgc tcaccgccgg ggcggtctcg gcggtgggcg cgctcggctt
     1081 cgtggggctg ctggtcccgc acgtcgcact cgccgtcttc ggcgccgacc tgcgagccac
     1141 cctgcccggc gccgctctgc tcggcgcggt cgtggtgggc ggcgccgacg cgggggccca
     1201 actgctctcc cgtgccctgg cccaggccct ggacgcggac cggctcaccg tccccgtggg
     1261 cgccctgacc acctgcgcgg gcgccgccct gctgctgatc gtggcccgcc gccgcgccga
     1321 cctgcgatga gcgggcggca ccgcacgccc ccgaggcgta ccgaagcacg gccgtgcggg
     1381 cgaccgcgcc gccggcaccg acgagtcacg gccccgcccg gcgagcgcgg gcggggccgg
     1441 aaggaggagt gatggaccat cgggaacccg gtgccgtggt cgcggaaggg ctgcggttcg
     1501 gctatccggg acgcgaggtg ctgcgcgggg tcgacctgcg gatcggcgcg ggcgaactgg
     1561 tcgccctggt cggcctcaac ggctgcggca agagcacctt cctgcggctc gccgccgggc
     1621 tgctgcgccc ggacggcggg cgggtcctgc tggacgggga ggaggtggca cggctctccc
     1681 gccggggcgc cgcccgccgc gtcgccctcc tccaccagtc ggcgccgccc gtaccggggc
     1741 tgaccgtccg ccagctggtc cggcaggggc ggtacgccgc ccgggggccg ctcgggatgc
     1801 tccgcgacgg ggacgacgcg gtgagcgcgc gggcgctggc cgacgccggg gtcgccgact
     1861 gggccgggcg gccggtcgac gcgctctccg gcggtgagcg gcagcgcgta cggctggcca
     1921 tggcgctggc ccaggacacc cggaccctcc tcctcgacga accgaccacg tacctggacc
     1981 tcaggcatca gctggaagtg ctccagaccg tggtccggct gcgcgcggaa cggggtctga
     2041 cggtggtgat ggtggtgcac gacctcaacc acgccgcccg gttcgccgac cggatcgtcg
     2101 ccctccggga cggccgggtg gccgccgacg gcaagcccgc cgacatcgtc acccccgccc
     2161 tcctcgccga cgtgctgggt gtcgaggggc gggtggcgcc ggacgagcgg ggcggctggc
     2221 cggtctgtta cccagatcac cctctggagg ccgcacgccc cttgcggact gaaaatcata
     2281 ttcattaagg tccgtgatgc ggcaggcgcc acgccgttca cgtccaccac gcaacgaacc
     2341 gaatggagct caactcatgg agcatgacaa ggtgttcgcc ccgatcgccg acccgggcca
     2401 gctggcccac ctctccgcca cccactccaa cgccctcgtc gagaacccct tcgacgacgc
     2461 cgacgagacc ggtgccgcgg acgacaagta gtcggacccg gccgccggtg acggcggccg
     2521 gctgacaccc gtgacgggcc cgcccggcga acccccgggc gggcccgttg cgttcggcgc
     2581 cccacggcac cggcgccgcc catcccctcg tactccatcc gacggaggtt tccgtgacca
     2641 gcagccgact cgccccgggc gccgggatcg tcaccgtccc cggcggccgg cccgccgtac
     2701 gcaccgccga gggcgagttc ctgcacctcg acaccggcgc cgccgacctc gccgcgctca
     2761 cccgccgcct ggtgagcggc gaagccgcct ccgacgccga agtggcgcgc gtcgcagcgg
     2821 cgttcgagcg cgagggtcac gcggtccggc ccgcccctga agagggcggc cggctcaccg
     2881 gccgtaccgt cctgctgctc ggcgacgcgc ggctcaccgg cccgctcgcc cggtacgcga
     2941 ccgctgaagg cgccctggcc cggcacgcca cccccgagca cgtcgcccgg ctcgccgacg
     3001 gtgaaggggc ggacgcgtcg accgccgtcg tctggtgcct cgacgagccg gtgccgcccg
     3061 ggctctggga cgtcgccgac cggctccccg cacacggcac ggcctggctg cgctgccacc
     3121 gcgagggcgc ccacctgtgg accgaaccgc tcgccgccgc acccggcgac gtcacctccg
     3181 cccacgtccg cctccgcccc tcgccgccac ctccgcccac cgccagctcg ccgcctactg
     3241 ggccggacac cgcacccccg acaacggccc gcaccccggc gaggccgccg ccgccctggt
     3301 cgccgccctc ctcaccgccg acctcctcgc ctgggccgtg ccgggcccga actccgggct
     3361 ccccgcgcga cgcaggctcc gccgcgtcga cctgcgcgac ctcaccgtca ccgaacaccc
     3421 cgtgctgccc gtaccgccgg tggccccgct gcccggccgg gggagcggcc cggcatgacg
     3481 cccgcgacca cccgcctcac cacccccgac ggcaccaccc tcgccaccga cctccacctc
     3541 cccgccaccc cgggctccca ccccgccgtg ctgatccgca ccccgtacga ccgccgtgcc
     3601 caccgggccg aactgcgcgg ctgggcggag cgcgggttcg ccgccgtcgc ccaggacgtg
     3661 cgcggccggc acggctcggc gggggagtgg cacccgtacc gcgaccacga ggcggaggac
     3721 ggcgtggcca cgctggactg gatacgcgcc cagccgtgga gcgacggccg cgtggtcgcc
     3781 gccggggcct cgtacgccgc gtactgcgcc ctcgccgctg ccctctcccc cggcgccccc
     3841 ggcccggacg cggtgatcgc cgccgtcccc gccctcggcc tgaccgagac ggcccgcgaa
     3901 cccaccggac ccgaacgcct gtgggcgcgc ctcggctggt gggcggccca cggcgaccgg
     3961 cccgactccg cacccgacgc cctcgcgcgc accctcgccc gcgacccgcg cctgcccgag
     4021 cacctgccgc tgacccggat cgcggaccgg ctcgaccgcc cgctcccctc ctggcccgcg
     4081 ctgtgggagg actgccggcg cggccgcctg gtcgcccacg gctccgccgc ccggctcccg
     4141 ctgctcgccg tcggcggcac ccgcgacccc ttcgccgagg acaccgtcgc cctctggcgc
     4201 ggctggggcg gccccgcccg gctgctgctc ggcccctggg gccacacgct cacggcgggg
     4261 acccgccccg gcaccccggg ccgcctcgac ctcggcgccc tctacgcccg ctgggccagg
     4321 gccgcgctcg acggggagat cggccccggg cggcgcggcg tcatcggcct cgcgcagagc
     4381 ggacgctggc accacctcac ggactccgtg acccggccag aagggtatga agtggccggc
     4441 gccgtgtggc ggttcggtgc cgccgacggc ctgcgcctcc tcgccggagc cgagttcacc
     4501 gccgacccgg accgtcccgt acgctccgac gacctcaccg tcccgcgtgg gcgcaccccc
     4561 gccgaccgct gcctgctcgc caccccgccg ctgccccgcc ccctcgacct ggcgggctcc
     4621 gccgaggccc ggctcaccgt cgtcgcggac acgccccgcg ccgactgggc cgtacgtgtc
     4681 gtcgccctcg acccggccgg acgcgccgac cccctcgcct tcgggatcgt ccggcgcgat
     4741 gccccgcccg gcaccccgca tcccgtcacc gtgccactcg ggaccctggg gcggaccctg
     4801 gccgccggga ccaccctgcg cgtcgagatc gccggccacc acttccccgc gcacgcccgc
     4861 aacccgcaca ccggcgagga ccccgtcacc gccacccgcc tggccgcctc ccgccgcacc
     4921 gtccgcaccg agggcagcgc cctccacctg cccgtggccg gccgcccccg ccccgtcgac
     4981 cccgtaccgg agacctgccg atgaccgccg ccctgcctct cgacgccctc gtcgaccctc
     5041 actgcggact cgtccgcgac gtcgcccccg tcccgcaccc cgagggcgcg ccgccgcgct
     5101 acaccgccat gaccgcgcac gtcgccgacg cccgccggtt cggggcctgg cccgccgacc
     5161 gggtctcgct cggcaccacc ttcggcgacc cggccggcgc ctggaccgcc gcagtcgccg
     5221 aagccgtcga acggtactgc ggcaaccggc tcccgccacc cggccacccc gacgcacccc
     5281 gccgcgccac cgccgcccag ctcaccgccg agggacacca gttgtacggc ccggacgacg
     5341 tgcccgccta cgcgccctgg cagtaccgcc gccccgcctt cccctacgcc ccgctcacgc
     5401 ccgacacccc cgcgctttgg gcgcgcggca cggagaacgg ccgcgactgc tgggcgccgg
     5461 tcgccctcac ccacctcaac tggcgccagg gagagctgcg ttcactgccg cgcacccacc
     5521 acctgaacta cgccggcatc gccaccggac agggactcgc ggacgccgcc gaacgcgccc
     5581 tcctcgaagt ggtcgagcgt gacgccctcg aactgtggtg gcacctggac gggcccaccc
     5641 ggggcatcga ccccggcagc gtccccgggc tcgacgccga cctcgccgga tgcggcctgg
     5701 aggtgagcat cgtcgagatg ccctcggagt tcgcgccctg cgtggccgcc ctggtccacg
     5761 acgcccggcg gggtgtccac gcggccgggt tcgcctgccg cttcgacccg gccgaagccg
     5821 cccgcaaggc cgtcctggag gccgtgcaca cctgggtctt caccctgggc gccgaagccg
     5881 ccgacggctg ggtgcaccag gccgtcgagg ccggtgtcct ggcccgcggg ctctatctgg
     5941 accaccgggc cgaccgccgc tacctcgacg actgcggcga ggagttcgcc gccgtacggg
     6001 acctcggcgc ccacgtccag gcatggctcg acccgcgcct cgcgcccctc gcccgccgct
     6061 tcaccgcacc cgccctcggc accgtccccg tcgccgagct cgcgcacggc agccgggacc
     6121 ggctcgacac cgccctcgcc gagggcggcc accgcgttct caccttcgac ctgaccaccg
     6181 aggacgtcgc cgagaccgcc ctgcgcgtcg cccgcgtcct ggtcggcgga ctcgtcccca
     6241 acgcccccgc cgccttcggc tactacggct gcccccgctt cgccaccgcc gctcccgccc
     6301 ggggctggcg ctcccaaccc ccgcgcgagc cgggcgactt cactctcgcc cccgccccgc
     6361 acatgtgacc ccggccctcc catgaccacc gacgccatcc tcggccacgc cctggccctc
     6421 gccagatcac cccgcacccc ggcccgcgcc accccacccc cgcgccgccc ctacccctgg
     6481 accggcaccc cgctcgccct ccccgccacc gcccccgacc ccgacggccc cgtcgacctc
     6541 gaccatctgc tccggcatgc gctgcgcgcc cgccccggta ccggtggccg gctgcgcccc
     6601 gccgcctccg ccggagcgct ccaccccgtc cgcgcccacc tcctgatcgg ccccggctgc
     6661 accttgcccc cgggacggta cgcctacgat cccgaggtcc accgggtgtt ccggcgcggc
     6721 ccggcacccc acggagcggc ccccggcatg atcgccgttc tcaccgccac cgccgaacgc
     6781 accgccgccc actacggcca ccgcgcctgg cccctgctgc tcctcgacac cggccacgcg
     6841 gccgccgccc tcgcactcgc cccgcaggga cccggcgtcc gcgtcagcct cgacgccgac
     6901 gccgccacgc tcgcggccgc cgccgggctg cccccggccg accgctggca gcggatacgg
     6961 cccggcaccg agaccgaaca ccccctcgcc gccgtccagc tgacgccccg ccgtacccag
     7021 tgcaccactc ccgccctcga ccgctggtcg gccctgccgc tcccggaccg catccgcacc
     7081 cccacccggc ccccggcccg gccctgcggc accggccgcc tgctggaact gctgggcgcc
     7141 gccaccggga ccgaaccgac ctggcacccc gtccgccgac ccgacgccgt caccggacgc
     7201 gccctgctgg atcgccgcag cgccgacccg gccgccctcg gccacccgcc ggacggcggg
     7261 acagtggccc gcatcctgcg caccgccgcc accgcctggc ccggcggccc cgcctggtgc
     7321 gccgccgtcg ccgcccccac ccccgccctg ttcgcccccg gccaccgcac cgccgacccg
     7381 caccgcctcg cccggggcga cgcccgcccc agcctcgccc actgggccgc aggccagctc
     7441 tggctcgccg acaccggagc ggtactcctc gcccacggct gtccctcgga cgcccccgcg
     7501 caccaggtcc gccaggacca cctcgccgcc ggcttcgccg cgggcaccgc ccatgcccac
     7561 gccgccgccg agggaatcgc cgcccgcccc gtcggctcct ggcaacaggc ggatctgggc
     7621 gcggccctgg gggagacccc gggacgcgac tgggtcctgc acggcctggc gctgggagcc
     7681 gcccgatgag ccgccgcccg cggcccgacc ctgaccaccc caccccgccc ggagagacgt
     7741 acccgcgatg atcccgcccc ccgaactgcg gcgcgccgcc cggcccgccg ccctgccact
     7801 ggccggcgcc accgccctgc tcgccctggt cggcgccacc cacatcgggc aggcggtgct
     7861 gctcgccctc gtcctcgccc gggtcgcccg gggcgagacg gccgggctgc ccgcgctgct
     7921 cgccgccgtg gccgccgtcg tgctggcccg cgcgctgctc ggccgcgccc agcggctgct
     7981 ggccgtccgc gccggagccc tggtccgcgt ccgcctccgc gacgacctcc tcgcccacct
     8041 cggtggaacc ggcccgggcg cgctcgccgg agcccgggcg ggagcggtgc gggccaccct
     8101 cgtcgacgga gtcgagggcg tggacgcgta cgtctcccgc catctgcccc acctgatcgt
     8161 cacctgcgcc ctcccgcccc tgctgctggt cgccgtcgcc ctcgtcgagc cgtacgccgt
     8221 ggccgcgctc gcccccgccc tcctgctggc gctcgccggg ccccgcctct gggaccggct
     8281 cctcgcccgc cggggccgcg agcactggga ctcctacgag gccctagccg ccgatcacct
     8341 ggaggccctc caggggatgg cggccctgcg cgccgccggc gccgtcggcc gcacccgggc
     8401 ccggctggag cggcgttcgg ccgcgctgca ccgggccacc gtggccaaga tgcgggtctc
     8461 cctcgccgac acgggcctca ccgacctcgc cgtgcagggc ggcaccgtcg ccgccgtcct
     8521 cgtcgcctgc gccgcagcca ccaccggggg caccgccgcg accggcacct atctgctgct
     8581 gttgctggcc tccgagtgct tccgcccggt ccgcgacctc tcccgcgagt ggcacgccgg
     8641 gcacctgggg ctgtcggccg tcgacggcat cgccgcgctg cgccacgccg agggcggcgt
     8701 ccccgacgag ggcaccgccg ccgactgggc cacgcccccc gaagtacgtt tcgagaacgt
     8761 ccacttcacc cacccgggac ggatccgacc cgccctcgcc ggcgtcgcct tcaccgctcc
     8821 ggccggacgc gtcaccgccc tggtcggccc ctccggcgcc ggaaagtcca ccctgctgag
     8881 cctcctgctc cgccagcgcg accccgactc cggccgggtc accgtcggcg gcctggacac
     8941 cgccgcgtac cggctcgacg cgctccgccg gggtatcgcc gtggtctccc aggacaccta
     9001 cctcttccgc gccaccgtcg ccgacaacct ccgcctcgcc cgccccgcag ccacctcggc
     9061 ccagctccac gaggccgccc gcgccgccgg catccacgag gagctgaccc ggctccccga
     9121 cgggtacgac acggtgatcg gcgaacgcgg cgccaccctc tccggcggcc agcgccagcg
     9181 cctcgccctg gcccgcgccc tgctcgccga cgccccggtc ctcgtcctcg acgaggccac
     9241 cagcgccgtg gacgaacgcg ccgaggcccg catcacccgg gaactcctgg cagccggacg
     9301 gggccgcacc tgcctgctcg tcgcccaccg cctcgaagcc gtccgccacg cagaccacat
     9361 cgtcgtcctc gaccacggcc gcgtcgacgc cgccggtacc cactccgaac tcctcgccgc
     9421 cgacggcctg tacgcccgcc tggtggccgc aggccggacc gtcaccccga tgcagcagga
     9481 ggccgcatga ccccgccgac cccgccggag ccaccggccg gcccgccccc gcacaaggcc
     9541 ctgcgctcgc tgctgcccgt gctcgccgcc caccgcgcca tgaccgcccg tacctgtgcg
     9601 gccgccctcg tcgaccaggc ggccctcgtc gtcctggtca ccctcgccgc ccacaccgtc
     9661 gggaccgctg tgatcgacgg gcggcccccc tcggcggcca ccatggcgct gctcgtcgct
     9721 ctggccgccg tgcgggcgct ggccacctgg cgcgagatgg acctctccca cgacctcgcc
     9781 taccgggtcc tggcactcct gcgcgtccgc gtcttcgacg ggatagcccg cagcgccccc
     9841 gcccgtgtcg ccggccgccg cagtggcgac ctcgcctcca ccgcgctggg cgacgtcgag
     9901 gcgttggagt tcttctacgc ccatgctctc gctcaactcc tcgccaccgg aacggtgttc
     9961 accgtctcgg cggccctgct gggcacccgc gaaccctggc tgctggccct cgtcctgccc
    10021 gccgccgcgc tcctgctcgc cctgcccgtt ctcgacggac gtggccgcgc cgcacgagga
    10081 gcccgcaccc gcacggccct cgccgacctc tccgccgaga ccgtggagac cgtcgacggg
    10141 ctgcgcgaac tcctcgcctt cggcgcgctg aaccgccggc gcgcccggtt gcgcgcgtac
    10201 gggcggcggc tggcccgcgc gcaacgggcc gagcagtcct gggaggccgg tgccgccgcc
    10261 ctgcgcgacc tgctggtggt ggccgccgtg atcggcgtcg tcgccgtcgc cggccacagc
    10321 gccgtcgagg gccgcctgca cggcgcctgg accccggccg ccatggcgct ggcgctcggc
    10381 gccctcgccc ccgtcgccga cgcagccgcc tcgctcgggc aggccggcag cctgcgggcc
    10441 gccgccgccc gggtccgggc cgccgccgac gcccccgccg gagcccccgc gccgagcacg
    10501 ccgcgcccgc tgcccgaggg ccccctcggc ctccggctgc gcggcgtgcg gttcgggtac
    10561 ggcggcacgc ccgtgctcga cggggtggac ctcaccgtcc gcccgggcga gaccgtcgcc
    10621 ctggtcggcg cctccggcgc gggcaagtcc acctgcgcgc acctgctggc ccgctactgg
    10681 gacccccagg agggcaccgt caccctcgtc cccgaggacg gacgaccgcc ggtcgccctg
    10741 cgagacctgg gcgacgccga gctgcggagc gccgtcgccg tcgtcggcca ggaagctccc
    10801 ctcttccacg gcaccctcgc cgagaacctg ctgctggccg cccccgacgc cccgccggac
    10861 gcgctggacc gcgcggtacg ggcctgcggc gtcgacaccc tcgccgccgg actccccgac
    10921 gggctgggta cggccgtggg ggagcggggt gccaccctct ccggtgggca gcgggcccgg
    10981 gtcgccctgg cgcgggcgct ggtcgccgct ccccgcgtac tggtcctgga cgagaccacg
    11041 gcccacctgg accacacggg ggacgcggaa ctcgccgccg ccctcgccgc ctcggccccc
    11101 gggcgcgcca cgctggtcat cgcccaccgg cccgccaccg tgcgccgggc cgaccgcgtc
    11161 gccgtcctgg aggacggccg gatcgtggag gagggcacct gggaggagct ggcgtccgcc
    11221 ggcggcgcgc tgacacgcct gctctcccgg gaggcgacgg caaccgcctg acctgtgccg
    11281 acgcgcacgc ccgcgtgcac gtggaagggc cggggtccct cgcggggacc ccggccctgt
    11341 cgtccggggg aggaatgctg cggctcag
//
