LOCUS       NZ_CM002273            22574 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces sp. PVA_94-07 strain PVA 94-07 chromosome, whole genome
            shotgun sequence.
ACCESSION   NZ_CM002273
VERSION     NZ_CM002273.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. PVA_94-07
  ORGANISM  Streptomyces sp. PVA_94-07
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Draft sequence of Streptomyces sp. PVA 94-07, a marine actinomycete
            isolated from the sponge Phakellia ventilabrum collected in the
            Trondheim fjord (Norway)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Assembly Name                     :: PVA94-07.23
            Genome Coverage                   :: 158.81x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495755.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:29:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,173
            CDSs (total)                      :: 6,079
            Genes (coding)                    :: 5,859
            CDSs (with protein)               :: 5,859
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 220
            CDSs (without protein)            :: 220
            Pseudo Genes (ambiguous residues) :: 0 of 220
            Pseudo Genes (frameshifted)       :: 97 of 220
            Pseudo Genes (incomplete)         :: 166 of 220
            Pseudo Genes (internal stop)      :: 15 of 220
            Pseudo Genes (multiple problems)  :: 55 of 220
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:06:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2912897
            Orig. end                         :: 2935471
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002273.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Department of Biotechnology,
            Norwegian University of Science and Technology, 7491 Trondheim,
            Norway.
FEATURES             Location/Qualifiers
     region          1..22574
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="15"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22574
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22574
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12574](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12574)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            381..1841
                     /locus_tag="B590_RS12235"
                     /old_locus_tag="B590_12403"
     CDS             381..1841
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896356.1"
                     /locus_tag="B590_RS12235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12403"
                     /product="MFS transporter"
                     /protein_id="WP_023417789.1"
                     /transl_table=11
                     /translation="MRRAARVVGRALRTPVTGPARGIRKVTHAQGAGESGLGRLIELHG
                     VNGAGDVMITVALASTVFFSVPTDEARGRVALYLAVTMLPFTLLAPVVGPLLDRLPHGR
                     RAAMAGSMLARAVLALVLSGAVATGSLEMYPAALGVLVASKAYGVVRSAVVPRLLPQGF
                     SLVKANSRVTLGGLLATGVAAPVGAGLQMIGPGWPLYGACLLFLGGAFLSFRLPPKVDS
                     ARGERRALLAADEQHLAAAVDARWDPVAEPVAEPAAEPVATGADRSDGTRNRGREKDRD
                     KERRRKGPGLRTVGPAVTHALAANACVRCQSGFLIFFLAFLLREHPLTGQSAAVSLAVV
                     GVAAGAGNALGTAVGAWLRARAPEVIIVTVVGALVAVAVSAAVFFGAAVVAVLGAVAGF
                     TQALAKLSLDALIQRDVPELVRTSAFARSETLLQMAWVVGGAIGIALPLRGPLGLSVGA
                     LIVALGWLTTVRALMASARRGASHPRVA"
     gene            1871..2395
                     /locus_tag="B590_RS12240"
                     /old_locus_tag="B590_12408"
     CDS             1871..2395
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415563.1"
                     /locus_tag="B590_RS12240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12408"
                     /product="hypothetical protein"
                     /protein_id="WP_023417790.1"
                     /transl_table=11
                     /translation="MTSLPRGGAARQFSPATRRGFAVLGAVSAGLLVLSACDKPTAVAT
                     VTIGSDSVNSEATCWNGGSKIDEKKLQQCLQDKGEGDSGNGAEVKTVKVDTEADVHIGV
                     DPKIADKGWTILMNGQPLTDASNKTFRTIPGSVFFNQQYGASGDSTVLSILENDGSSAT
                     GLWSFKLEKES"
     gene            2416..3141
                     /locus_tag="B590_RS12245"
                     /old_locus_tag="B590_12413"
     CDS             2416..3141
                     /EC_number="3.2.2.26"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643335.1"
                     /locus_tag="B590_RS12245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12413"
                     /product="futalosine hydrolase"
                     /protein_id="WP_023417791.1"
                     /transl_table=11
                     /translation="MRLLVATAVPPERDAVARAFGAPDTPEETALPGAVLLRTPGADVL
                     AAGVGPAAAASATSAALTAARLAGNPYDLVVSAGIGGGFAERAPVGAVVAADRIVAADL
                     GAETPEGFVPVTGLGFGTDVHVPPAALVEAAREAGLVPGAVLTVSTVTGSAGRASELLA
                     RHPSAVAEAMEGFGVAEAAAAHGVPVLEIRAISNAIGPRDRDAWRIPAALTALTSAFVR
                     LAPAEAGSPFALARARLVP"
     gene            3209..4105
                     /locus_tag="B590_RS12250"
                     /old_locus_tag="B590_12418"
     CDS             3209..4105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415567.1"
                     /locus_tag="B590_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12418"
                     /product="1,4-dihydroxy-6-naphthoate synthase"
                     /protein_id="WP_023417792.1"
                     /transl_table=11
                     /translation="MSESGTGGGVRGTADEAGRLSIAYSPCPNDTFVFDAVAHGRVPGA
                     PALDVTFADIDLTNGMAERGEYDVLKVSYAALPWLLDEYALLPCGGALGRGCGPLVLTR
                     EASLPGALAGRTVAVPSERSTAYLLFRLWAADQVPGGVGEIVVMPFHEIMPAVRDGKVD
                     AGLVIHEARFTYQNYGLHKLADMGEHWEATTGLPIPLGAIIARRSLGAGRLTALAQALR
                     TSVRMAWDDPAASRPYVMAHAQEMDADVADQHIGLYVNEFTADLGEDGYAAVRGLLTRA
                     AAEGLVPPLAPDALRFP"
     gene            complement(4193..4576)
                     /locus_tag="B590_RS34325"
                     /old_locus_tag="B590_12423"
     CDS             complement(4193..4576)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642928.1"
                     /locus_tag="B590_RS34325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12423"
                     /product="cold-shock protein"
                     /protein_id="WP_023417793.1"
                     /transl_table=11
                     /translation="MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVEALKPGQR
                     VEFGVVAGQRGDQALSVVLLDPAPSVAAAQRRKPDELASIVQDLTTVLENVSRSLERGR
                     YPDKASGAKVAGMLRAVADQLDV"
     misc_feature    complement(4624..4633)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.3"
                     /tool="antismash"
     gene            4718..4969
                     /locus_tag="B590_RS12260"
                     /old_locus_tag="B590_12428"
     CDS             4718..4969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950020.1"
                     /locus_tag="B590_RS12260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12428"
                     /product="hypothetical protein"
                     /protein_id="WP_023417794.1"
                     /transl_table=11
                     /translation="MSDTTQQTPAPGDRLVKTGGIVFIIGALATLVTVAPLFLGSDPFP
                     TAAYLVSMLMGVGFLIAGAGLVRSISAQRRETRAAVEG"
     gene            5241..5912
                     /locus_tag="B590_RS12265"
                     /old_locus_tag="B590_12433"
     CDS             5241..5912
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142169.1"
                     /locus_tag="B590_RS12265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12433"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023417795.1"
                     /transl_table=11
                     /translation="MSRVQVIHSSGVLRSALVALLERERFQVTGSAGFTRASSGTTAAP
                     AAVTVVDSSCPVGAAHLERRSLQGSAKEPTHATPALAAARPGLGLAGAGGGRAALVVLA
                     GAEHPGVLRLAYAAGALGLVDRDGPAGHLATAIRLAAGGGRYVDDGLAVSLLRAMDMPL
                     SPREVRVLSRAAQGDSVAEIARGLCLSHGTVRNYIASATRKVGARNRVDAIRISRAAGW
                     V"
     gene            complement(5887..7911)
                     /locus_tag="B590_RS12270"
                     /old_locus_tag="B590_12438"
     CDS             complement(5887..7911)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890596.1"
                     /locus_tag="B590_RS12270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12438"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023417796.1"
                     /transl_table=11
                     /translation="MTDRHAPGATPRPLLRPALTFARRRKGPLGALAAWSLLESARTFL
                     TGYAVARALDDGFLASDVRTGLLWLLALAAAALTGGLADAGVFRSLGSVIEPLRDSLVR
                     RVVRATLTRAATSPTPADTARVSRLTAQTEIARDAAGGVLLTVRSFLFTSVGALTGLAA
                     LSPRLLPLVLIPLAAGLALFAATLRPMAARQRDLLDADEHLAAFAGRTDHAARDIAATG
                     AAPSVTAEAAPLITAEATAASALARWSAVRVTALGLAAHLPVATLLLAAPTLLPTGLTP
                     GELLAALTYVTTALLPAVNALLTALGTAGSRLLVVLHRLLGEEGDVRGKQADVLGVTDR
                     VRGPGASSHGRADEGPAIPAPPLPGPGHVPEPSRAEPSTLGPRPTRPAPPAATLRGVTF
                     AYGPDATPVLDHLDLTVQPGEHLLVVGPSGAGKSTLLALLAGTAHPRHGQIHLGGHTAR
                     HARTLGTAARVLVPQEPYIFEAPLRDNLTYLAPDAPGSRITEALDTFALTSLATDASRP
                     LRPDRLTPSERRRIALARAWLTPSPLLLLDEPTAHLDAGARAATEPAFASHPATVITVS
                     HHFPVPEPGQRVLLLDGATPYLGTHASLLQESALYRELAAEGGAAFDGGDPEHRVDLGV
                     SGEQPRPGALTTRPEPTRQGPPPPRPGPQQPLRPTPPRG"
     gene            complement(7908..9629)
                     /locus_tag="B590_RS12275"
                     /old_locus_tag="B590_12443"
     CDS             complement(7908..9629)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471139.1"
                     /locus_tag="B590_RS12275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12443"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023417797.1"
                     /transl_table=11
                     /translation="MTAAPADADRARATPGPPPDEGRLLREAVRRGRGPAALVLAATVL
                     GAAAAVTLPLALGRAVDLLIARADAGFWVLLCSALIAAEVATDALVARTGGRTGAATTA
                     WLRRRALAGFLAAPPAATTGTGLPTRLTANALDAGTAPVAAATAAAAGLAPLGGLAGLF
                     LVDPWAGAAFVCGVPLLLMILRALLRDGRAALTTYQEEQGRMARLLTGALTGAATIAAA
                     GTARAEERRVLAPLAGMRAAGERTWRVQGRAAGLSGALMPLLVAAVLAVGGVRLVAGHL
                     TPGDLLALSRYAVLAAGAGALAGALNGWVRAKAGTARVETVTALPPTPHGTRDLPPHGD
                     GTLALCGVHVTRDGIPLLHDITLTLPGGTTTALVGPSGAGKSLLAAVAGRLTDADQGSV
                     LLDGTDLRTLSADALRRAVAYAFERPALFGTTVADAVACGPLPEADLRQALRRAAADTF
                     TDRLPHGTRTPLAEAPLSGGELQRLGLARAFTRPTRLLILDDATSSLDTVTAHLVGRAL
                     TEAPGTRLTVTHRLSAAARADQVVWLDKGRVRGTGPHHTLWHDPAYRAVFGTETDT"
     gene            complement(9790..9921)
                     /locus_tag="B590_RS12280"
                     /old_locus_tag="B590_12448"
     CDS             complement(9790..9921)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="B590_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12448"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_008415578.1"
                     /transl_table=11
                     /translation="MALLDLQAMDTPQEEAVGDLATGSQISLLICEYSSLSVTLCTP"
     CDS_motif       complement(9856..9921)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQAMDTPQEEAVGDLAT"
                     /locus_tag="B590_RS12280_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9790..9855)
                     /prepeptide="core"
                     /locus_tag="B590_RS12280_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="30.10"
                     /molecular_weight="2088.4"
                     /monoisotopic_mass="2087.1"
                     /core_sequence="GSQISLLICEYSSLSVTLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQAMDTPQEEAVGDLAT"
                     /leader_location="[9855:9921](-)"
                     /alternative_weights="2106.4"
                     /alternative_weights="2124.5"
                     /alternative_weights="2142.5"
                     /alternative_weights="2160.5"
                     /alternative_weights="2178.5"
     gene            complement(10001..12574)
                     /gene="lanKC"
                     /locus_tag="B590_RS12285"
                     /old_locus_tag="B590_12453"
     CDS             complement(10001..12574)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507351.1"
                     /locus_tag="B590_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12453"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_023417799.1"
                     /sec_met_domain="micKC (E-value: 1.2e-226, bitscore: 753.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4.5e-12, bitscore: 44.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 0.00018, bitscore:
                     18.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYALYSGADRWFYDTPRRAGRAGDGNGNDGHRYALALRPAPG
                     GWESAERGDWFSLAPAGRQLPAQGWKIHVSATPDNAEQVLETVAGICQERATAFKFLAG
                     PALLLHRNTKYADRAGSGKFVTVYPATTAACGELAAELADALKGSAGPVVLSDLRWGEG
                     PVHVRYGAFAPRFTRTADGSLVPAVADPTGRLVPDTRGPAFRLPDWVALPDFLRPHAEA
                     RAAQGTNGLPYTVERALHFSNGGGVYAGSHRETGEAVVLKEGRPYAGLAADGADAVTRL
                     EREYAALRALEGLACVPRVHGLHTVGEHRFLAMEFIPGTPLNTVFARRFPLSAAEPAAE
                     ALAEHTAWALRTHQLVTEAVEALHARGIAFGDLHMNNIMVAPDQLSVTLLDFEAATPAA
                     ERRPQIVANPAFVAPPHLRGTEVDRYALACLRLALFVPLTTLLPLDRDKAAHLADLAAD
                     RYGIDRALFDEAVTELAGPARPEAATPRGRPPVSATDWPAARDSMVAALLASATPDRDD
                     RYFPGDIAQFATPAGGQSYGYGAAGVLHALHTVGARCEEAEEWLIRTTRRPASGTPAGF
                     YDGLTGIAWTLDRLGHREDALRLAHLVAAEPLDALGPGLHSGAPGVALALRDLADGADD
                     PALGKAAGRAEAAALRSAAPGGKAGLLHGPAGTALLCLRRHARTGEPALLDTAATALRQ
                     ELSRCVPGPDGSLVVSEARRTMPYLGSGSAGIAMVLDDYLAHRPDPAFEEARTALLRAT
                     GSAFYIQPGLFRGVAGLLLHLARTTTPVDRAARTALLARQTALLDWHALTYEGQLAYPG
                     EQLTRLSMDLSTGTAGVLLALAATHGEPAAHLPFLPPLRRPTDRP"
     gene            complement(12770..13744)
                     /locus_tag="B590_RS12290"
                     /old_locus_tag="B590_12458"
     CDS             complement(12770..13744)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126551.1"
                     /locus_tag="B590_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12458"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_023417800.1"
                     /transl_table=11
                     /translation="MTRRTARPLLAATGALALAVTLTACGSGEETAADAGKDAGATRTV
                     KTAMGEVEVPEAPKRVVVLDTAELDSALTLGVKPVGAVRSDAAGGFAGYLPQRELAGIE
                     NVGVIAQPNLEAIAALKPDLILTSKVRDEARYAQLSKIAATVMTENTGYPWKENFQLHA
                     EALGKQKEADRATAAYEKRTAEVTEAVGGPAKAKETEVNVVRFVEGADIRIYGRKNYIG
                     TLLADVGLGRPAVTDKAADGFSYDVSPEKIDLADADVVFTATYGDPEKARETRTTRSAL
                     WRSLDAVKSGAVHKVEDELWIQGIGYTAAQQILDQLEEALTPS"
     gene            complement(13741..14598)
                     /locus_tag="B590_RS12295"
                     /old_locus_tag="B590_12463"
     CDS             complement(13741..14598)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950013.1"
                     /locus_tag="B590_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12463"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023417801.1"
                     /transl_table=11
                     /translation="MTRPAARLTARDLTLAYEDRTVVPGLDLDVPDGRVTVIIGPNACG
                     KSTTLRALGRLLRPAGGAVLLDGTELARLPTRQIARRIGLLPQTPVAPEAITVADLVAR
                     GRQPHQRWWQQWSAEDERAVTEAMARTATTDLADRPVDALSGGQRQRVWIAMALAQETD
                     LLLLDEPTTYLDLAHQVEVLDLVRRLNREQGRTVVLVLHDLNQAARYADHLIAFREGRV
                     VAEGAPAEVVTAGLVREIFGLECVVVPDPVTGSPLVVPGAPWDARQPAPEPAAPTREES
                     RATP"
     gene            complement(14595..15674)
                     /locus_tag="B590_RS12300"
                     /old_locus_tag="B590_12468"
     CDS             complement(14595..15674)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896363.1"
                     /locus_tag="B590_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12468"
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="WP_023417802.1"
                     /transl_table=11
                     /translation="MLKAGPVPARVRPAGYVPVRLGAVSLLVPVRAVATGAVLAAVLAV
                     VCVAYLSVGESFVAPGSVVDVLLGRPSPDTLVVGELRLPRMVAGLYVGAAFGIAGALIQ
                     TVARNPLASPDLIGVSQGASAATVAALTFGVTSYAVLPWISLGGGLLAALLVYLFAWRG
                     GLQATRFVLVGVGFAVALRALTTLFLTKGDQTVAQQAQVWMSGSLNGRAWPEAALVGWT
                     LLAALPALVWAARVQRTVTLDDATATGLGAHLGRARLGLVLIGVVLASVATGAAGPVDF
                     VALLAPQIARRLTRTAQIPLVCSALAGAVTVVAADLLARRLFAPTELPVGVLTAAVGAP
                     YLIWLLVTRHGPRATGGTS"
     gene            complement(15682..16746)
                     /locus_tag="B590_RS12305"
                     /old_locus_tag="B590_12473"
     CDS             complement(15682..16746)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896364.1"
                     /locus_tag="B590_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12473"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_023417803.1"
                     /transl_table=11
                     /translation="MPPAPPAAPPLAKAPPPASRPRRDSAVHRAAWTVAALVALLVAVV
                     LSLAVGARTVAPGTVVEALFQGATGPDAEVVREMRLPRTLIGVMVGAALAVAGTALQGI
                     TRNPIADPGILGISQGASVGVVLAIAFAGVHTLAGYVWFAFAGAGLAAVAVYAVAAGGR
                     GGATPVKLALSGAAVNALLVSVTTAVLTTSSSALDEFRFWNVGALQGRDAEVAVQVWPF
                     LLVGLALVASSARGLDALALGEDVAKGLGQRVGAVRITAGAGAAVLTGVGVAAAGPVAF
                     VGLAVPHLVRHLAGGDHRWVLPLAALTGPVMLLASDTVGRVLFPPGEVPAGVMTALIGV
                     PFLVALVRGRVVTG"
     misc_feature    16834..16854
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(16835..16855)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            16884..17570
                     /locus_tag="B590_RS12310"
                     /old_locus_tag="B590_12478"
     CDS             16884..17570
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507353.1"
                     /locus_tag="B590_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12478"
                     /product="HAD family hydrolase"
                     /protein_id="WP_023417804.1"
                     /sec_met_domain="HAD_2 (E-value: 6.1e-08, bitscore: 31.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEHLTSPAAPTPSGPAVPAARPAPGGAGPVVGFDLDMTLIDSRP
                     GIGAAYRVLAAETGVPIDVDLVVSRLGPPLETELACWFPAEQVPAAAARYREVYPSTAV
                     APSLALPGAAQALEAVRAHGGRSLVVTAKNEEHARLHLDHLGLRAELVVGSLWAEAKGG
                     ALRAQGATVYVGDHVGDVRGAQAAGAFSVAVATGGCTPDELRAAGADVVLPDLAAFPAW
                     LAEFAR"
     gene            complement(17641..17856)
                     /locus_tag="B590_RS32775"
                     /old_locus_tag="B590_12483"
     CDS             complement(17641..17856)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B590_RS32775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B590_12483"
                     /product="hypothetical protein"
                     /protein_id="WP_023417805.1"
                     /transl_table=11
                     /translation="MADVWAGEKLRLRGVEPEDWRDFRELARDLDGVCAAGPAGPPRSD
                     GNLRGGAAPPGQDGERTAKPYGPAGV"
     gene            18066..19088
                     /locus_tag="B590_RS12320"
                     /old_locus_tag="B590_12488"
     CDS             18066..19088
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507354.1"
                     /locus_tag="B590_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12488"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_037969551.1"
                     /transl_table=11
                     /translation="MKQPARTAGGAVAEEARPVEGVEGDEPGRAAEWWVALRRTPGAFW
                     RDDVSDFAAALTYYAILAVLPALLVVVIAFGLVSPDTAERFVGQVTAWAPGGSGASLRE
                     VLTRVVRVDSTAWTLLVTGGASALWSASSYLAVSRRALHRMYGVRDRRSPWGKAHRIVA
                     TALALLSLLLVSSLLLMLTEPVAESIGRLLGLDAGVAWAWSVVRWPLLLCLVACLVVVV
                     FRNGPAAARRRAHSIPGGVLAATLWLTASAGLALYASVLSTYSRLYGSLAGIVVFLVWL
                     WLSNVALLLGAQFTAELCRAEGGPGAPACRPGPVEGMAAEDVPADTDAAQEHGRAPTGA
                     "
     gene            19209..21134
                     /locus_tag="B590_RS12325"
                     /old_locus_tag="B590_12493"
     CDS             19209..21134
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950008.1"
                     /locus_tag="B590_RS12325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12493"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_269469413.1"
                     /transl_table=11
                     /translation="MTHGQLGPIHDSLATVTLQSVITEREIPLRHSSISASASVADDLL
                     FATRGEEHLRWRELFSTEEFGHRDLPHRERVELSYRRLRTVAAAIPDPRALALSAPALT
                     ALHEWAGPADPGMATLASIHYNLFLGSLLDHDHAERDLGPWLRMDRIGTFLCTEAEHGN
                     DAVNMETTAEYDRASRQFVLNTPGPGAAKWMPNTSLTGGPKDAVVAARLLVDGRDLGIF
                     LFLTPLSDERGHLPGVSVERLPHTSGAPVDHCATRFHHVRLPHSAMLQGDHGRLSPEGE
                     FESTLGSPRIRFLRSIGRVSMGKLCMSGYSLGATRQAIAVAVRHGSTRLTSGMTKGRRV
                     PLMAHRSHHEPLLDALATTYAATLLHRSVVRQWEVAEEAEREEVDRLVAVTKGWITWAA
                     RETMTTCRERCGAKGLLLTQGIAGQLAANEGTITAEGDNKVIWVKAAGELLMGGFTPKP
                     PSETAPEQRSLRDGTHLQDLMADVERIWHERARTRLRSGGVRGNPMARWNGAVTPALEL
                     VAAHAHRLAGEALLEGTDRVSADEAERIRDLHRLFALRQVAAHSGELLAGERLTAEQVR
                     RLPDEVERVVADLEPHILALTERFFVPENLPGSDPAGLVEAAPEALAAGTEARTGGLRE
                     SEPDAA"
     misc_feature    complement(19224..19237)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(19255..19268)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.71"
                     /tool="antismash"
     misc_feature    19260..19262
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21247..22563)
                     /locus_tag="B590_RS12330"
                     /old_locus_tag="B590_12498"
     CDS             complement(21247..22563)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643357.1"
                     /locus_tag="B590_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_12498"
                     /product="cytochrome P450"
                     /protein_id="WP_023417808.1"
                     /transl_table=11
                     /translation="MHDANFAADPQAVYEQLREQGPAGPVELAPGVDATLVVGYETALR
                     VLQNPTSFPRDARRWAALNEGRVPMDSPVLPMMAYRPNALFTDGAVHLRLRKAVTDSLA
                     KLNITRIRRDVEPIADYLIDQFSERGRADLLAEYAKLLPLLLFNKLFGCPAEIGDTLTT
                     EMSAMFDGKDPVRTKARLDACLMQLIAIKRREPADDVISWLIQHPAGLTDEELKDQLVM
                     LMGAGIEPERNLIGNALLELLSGGAGGRGAGMMVEEAVDHVLWHRTPIANYAAHYPAQD
                     TDFGNGVIAPAGSPVLISFAGANSDPALAEARRSAGRGAHLAWGAGSHACPAKDPAQVI
                     AVTAVEKILNALPDLTLGVPEEELQWRPGPFHRALVSLPVAFSPTPATRMAAALQSRGV
                     PQQQVAPATPQPQHTAPASSDGGGRRKGFWSSFLDIFRV"
ORIGIN
        1 agtcgcatgc ggcggagacg ggcagcggac ggagcggacc gctgggccgc gtcgacgtcc
       61 gcgcccgatc gtccagggca cgcccacgcg aaccattctg ggggatcgcg aagaggcgcg
      121 cggccgggag taccgtcgca ggcgcgtgag tgcacgctac cctctcgcgg gcccgtctcc
      181 cacaccgacg tgggaagccg ggccgctcag gggcgtcggc ggcgcgtcgt acgggtgcgg
      241 gcgagcggcc cggcgagggg tggcgcggcc ccgcttcggc cacaggggtt gctcgggaca
      301 cttcgggtca tactcggccc gccagggggc actatcacca cgtgaccgcc tcaggctcgc
      361 cacgcgtgga gcgcagcccg gtgcgcaggg ccgcccgggt tgtgggccgc gcgctgcgga
      421 ctcccgtgac gggcccggcg cgcggcatcc gcaaggtgac gcacgcgcag ggcgcgggcg
      481 agtcggggct cgggcggctg atcgagctgc acggggtgaa cggcgccggc gacgtgatga
      541 tcacggtggc gctggcctcg acggtcttct tctcggtgcc gacggacgag gcgcggggcc
      601 gggtggcgct ctatctggcc gtgacgatgc tcccgttcac gctgctggcg ccggtggtgg
      661 gtccgctgct ggaccggctg ccgcacggac ggcgggcggc gatggccggg tcgatgctgg
      721 cccgggcggt actggcgctg gtgctgtcgg gggcggtggc gaccgggagc ctggagatgt
      781 acccggccgc gctcggcgtc ctggtggcct cgaaggcgta cggggtggtg cgcagtgccg
      841 tggtgccccg gctgttgccg caggggttct cgctggtcaa ggccaattcg cgggtgacgc
      901 tcggcgggct gctggccacc ggggtggcgg cgccggtcgg ggcggggctc cagatgatcg
      961 gcccggggtg gccgttgtac ggggcgtgtc tcctcttcct cggcggcgcg ttcctctcgt
     1021 tccggctgcc gccgaaggtc gactcggcgc gcggcgagcg gcgggcactg ctggcggcgg
     1081 acgagcagca tctcgcggcg gcggtggacg cccgctggga cccggtggcc gagccggtcg
     1141 ccgaaccggc ggccgagccg gtggcgacgg gggccgaccg cagtgacggg accaggaaca
     1201 gggggaggga gaaggacagg gacaaggagc ggcggcggaa ggggccgggg ctcaggacgg
     1261 tggggccggc ggtgacacac gcgctggcgg ccaacgcctg tgtgcggtgt cagagcggct
     1321 tcctcatctt cttcctggcg ttcctgctgc gcgagcatcc gctgacgggg cagagcgcgg
     1381 cggtgtcgct ggcggtggtc ggtgtggcgg cgggggcggg gaacgcgctg gggacggcgg
     1441 tcggcgcgtg gctgcgggcc cgggcgccgg aggtgatcat cgtgacggtg gtgggggcgc
     1501 tggtggcggt cgcggtgtcg gcggcggtgt tcttcggtgc ggcggtggtg gcggtactgg
     1561 gggcggtggc cgggttcacc caggcgctgg ccaagctgtc gctggacgcg ctgatccagc
     1621 gtgatgtgcc ggagctggtg cggacgtcgg cgttcgcccg ttcggagacc ttgctgcaga
     1681 tggcgtgggt ggtgggcgga gcgatcggga tcgcgttgcc gctgcgcggg ccgctggggc
     1741 tgagcgtggg cgcgctgatc gtggcactcg gctggctgac gaccgtacgg gcgctcatgg
     1801 cgtcggccag acgcggcgcg tcgcaccccc gcgtggcgtg accctccaac gggcccgata
     1861 gccttcgccc atgacatccc tgccccgcgg cggagccgca cgtcagttca gcccggccac
     1921 gcgccgcggg ttcgccgtcc tcggcgcggt gtccgccggc ctgctcgtcc tgtccgcctg
     1981 cgacaagccg acggcggtcg ccaccgtcac catcggctcc gactcggtga actccgaggc
     2041 gacgtgctgg aacggcggct ccaagatcga cgagaagaag ctccagcagt gcctccagga
     2101 caagggtgag ggcgactccg gcaacggcgc cgaggtgaag accgtgaagg tcgacaccga
     2161 ggccgacgtg cacatcggcg tcgacccgaa gatcgccgac aagggctgga cgatcctcat
     2221 gaacggccag ccgctgaccg acgcgtccaa caagaccttc cggacgatcc ccggcagcgt
     2281 cttcttcaac cagcagtacg gcgcctccgg cgactccacc gtcctctcca tcctggagaa
     2341 cgacggcagc tccgccaccg gcctgtggtc gttcaagctg gagaaggagt cctgacccgc
     2401 ctgcccacgc ccgccgtgcg gctgctcgtc gccaccgctg tcccgcccga gcgggacgcg
     2461 gtggcgcgcg cgttcggggc gccggacacc ccggaggaga cggccctgcc cggcgcggtg
     2521 ctgctgcgca ccccgggcgc cgacgtactg gccgccgggg tcggcccggc cgccgcggcg
     2581 agcgccacct cggcggcgct gacggcggcc cggctcgcgg gcaaccccta cgacctggtc
     2641 gtctcggccg ggatcggcgg cggtttcgcc gagcgggcgc cggtcggcgc ggtggtggcc
     2701 gcggaccgga tcgtcgcggc cgacctgggc gccgagacac cggagggctt cgttccggtg
     2761 accgggctcg gtttcggtac ggacgtgcac gtgccgccgg ccgcgctggt cgaggcggcc
     2821 cgcgaggccg ggctcgtgcc gggcgcggtg ctcaccgtct ccacggtgac gggcagcgcg
     2881 ggccgtgcct ccgagttgct ggcccgccac ccgtcggcgg tggccgaggc gatggagggc
     2941 ttcggtgtcg cggaggcggc cgccgcacac ggcgtaccgg tgctggagat ccgcgccatc
     3001 tccaacgcca tcggcccgcg cgaccgtgac gcctggcgca ttcccgccgc cctcaccgcg
     3061 ctgacctcgg ccttcgtccg cctcgccccc gccgaggcgg ggagcccctt cgccctggcc
     3121 cgcgcccggc tcgtaccgtg agcggtggca gtacgcgcgg cacaggcggc gcgagcagtg
     3181 gcagcagcag ggaaggcgag gcggcgacat gagtgagagc ggtacgggcg gcggcgtccg
     3241 ggggacggcg gacgaggccg ggcggctgag catcgcctac tccccctgcc ccaacgacac
     3301 cttcgtcttc gacgcggtcg cccacggccg ggtcccgggc gcgccggcgc tcgacgtgac
     3361 cttcgccgac atcgacctga ccaacggcat ggccgagcgc ggcgagtacg acgtcctcaa
     3421 ggtctcgtac gcggcgctgc cctggctgct cgacgagtac gccctgctgc cgtgcggcgg
     3481 ggcgctcggc cgggggtgcg gcccgctggt gctgacccgc gaggcctcgc tgccgggggc
     3541 gctggccggg cggacggtgg cggtgcccag tgagcggtcg acggcctacc tgctcttccg
     3601 gctctgggcg gcggaccagg tgccgggcgg ggtcggggag atcgtggtga tgccgttcca
     3661 cgagatcatg ccggcggtcc gggacggcaa ggtcgacgcg ggcctggtca tccacgaggc
     3721 gcgcttcacc taccagaact acggcctgca caagctggcc gacatgggcg agcactggga
     3781 ggcgacgacg ggcctgccga tcccgctcgg cgcgatcatc gcccgccgct cactcggcgc
     3841 cggccgcctg accgcactgg cccaggcgct tcgtacctcg gtccggatgg cgtgggacga
     3901 ccccgcagcc tcccgcccgt acgtcatggc gcacgcccag gagatggacg cggacgtcgc
     3961 cgaccagcac atcggcctgt acgtcaacga gttcaccgcc gacctcggcg aagacgggta
     4021 cgcggccgta cgcggcctgc tgacccgggc ggcggccgag ggcctggtcc cgccgctggc
     4081 cccggacgcg ctgcgtttcc cgtgaccgaa acggctggac cacgtacgac gagacctccg
     4141 gatcacgctg gttccggcgg tctcgtcgta ggcgctgaag ggtgcagctc gctcagacgt
     4201 cgagctggtc ggcgacggcg cggagcatgc cggcgacctt ggcgccggag gccttgtccg
     4261 ggtaccggcc gcgctccagg ctgcggctga cgttctccag gacggtggtg aggtcctgga
     4321 cgatggaggc cagctcgtcg ggcttgcggc gctgcgcggc ggcgaccgag ggcgccgggt
     4381 cgaggagcac cacggaaagt gcctggtcac cgcgttgacc ggcgaccacg ccgaactcca
     4441 cccgctggcc gggcttgagc gcttcgacgc cggcgggcag cacggacgag tgcacgaaga
     4501 cgtcgccgcc gtcgtcgcgg gagaggaagc cgaagccctt ctcgctgttg aaccacttga
     4561 ccttgccagt cggcaaagca ctgtcccttc tcgccctgcc gccgtccggc cgcagtgtcc
     4621 tggtcacata tcagggggga tgtacccacg gcgaagctat cccatccgct ccaccccggc
     4681 gcggagatta cgggggccgg gcaactaccc tggacccgtg tccgacacca cccagcagac
     4741 cccggccccc ggcgaccgcc tcgtgaagac cggcggcatc gtcttcatca tcggcgccct
     4801 ggcgaccctc gtcaccgtcg cgcccctctt cctcggctcc gacccgttcc cgaccgccgc
     4861 ctacctggtc tccatgctga tgggcgtcgg cttcctcatc gcgggagccg ggctggtccg
     4921 ctccatcagc gcgcagcggc gcgagacgcg ggctgccgtc gagggctgag cgccatgccc
     4981 cgcccggcac gctccggctc acttccgaac gttccgggcg ccacgcgcgc ccccttccgc
     5041 gccctccccc gctctccggc tcccgccgat gatgggcccg ccgccgatct gcggcgacca
     5101 cggacgccgc cgctccgctg gcggaaccgt ttcgccttcc ggacggcgac ggccgtcggc
     5161 caaggctgaa cagtgagggc gccgcctccc acccggagcg cgacgccacg ctgagtctcc
     5221 ggaaagcgga aggcggaacg atgtctcgcg tacaggtgat ccacagctcg ggtgtcctgc
     5281 gatcggccct ggtggccctg ctggaacgcg aaaggttcca ggtcaccggc tcggccggct
     5341 tcacgagagc ctcgtccggc accaccgccg cccccgccgc ggtgaccgtc gtggacagct
     5401 cctgtcccgt gggagcggcc cacctcgaac gccgctccct gcaaggctcc gccaaggaac
     5461 ccacccacgc cacccccgcc ctcgccgccg cccggccggg gctgggcctc gccggagcgg
     5521 gcggggggcg agcggccctg gtcgtcctcg ccggggccga acaccccgga gtcctccgcc
     5581 tcgcctacgc ggccggcgca ctcggcctgg tcgaccgcga cggccccgcc ggccacctgg
     5641 ccaccgcgat acggctggcc gccgggggcg ggcggtacgt ggacgacggg ctggcggtga
     5701 gcctgctccg ggcgatggac atgccgcttt caccgcgtga ggtgcgggtg ctgagcaggg
     5761 ccgcgcaggg ggattcggtg gcggagatcg cgcgggggtt gtgcctgtcg cacgggacgg
     5821 tgcggaacta cattgcttcg gccacccgga aggtgggggc caggaatcgg gtggacgcga
     5881 ttcggatcag ccgcgcggcg gggtgggtct gaggggctgc tgcgggcctg gacggggtgg
     5941 gggcgggcct tggcgagtgg gctcggggcg ggtcgtcagt gctcctgggc gtggctgctc
     6001 cccgctcacg ccgaggtcga cgcggtgctc cggatcccca ccgtcgaagg ctgccccacc
     6061 ctccgctgcc agttcccggt acagggccga ctcctgcagc agcgaggcgt gggtccccag
     6121 gtaaggcgtc gccccgtcca ggagcaggac gcgctgccct ggttcgggta ccggaaagtg
     6181 atggctcacc gtgatcaccg tggccgggtg ggaagcgaaa gctggctccg tggcagcccg
     6241 cgcccccgcg tccaggtggg ctgtgggctc gtccaggagg agcaggggcg aaggcgtcag
     6301 ccacgctcgg gcgagggcga tgcgacggcg ttcggacggg gtgaggcggt ccgggcggag
     6361 agggcgggac gcgtccgtcg cgagggaggt cagggcgaag gtgtcgaggg cttcggtgat
     6421 gcgggagccg ggggcgtccg gggcgaggta ggtgaggttg tcgcggagag gggcctcgaa
     6481 gatgtagggc tcctggggga cgaggacgcg ggcggccgtg ccgagggtgc gggcgtggcg
     6541 ggcggtgtgg cccccgaggt ggatctggcc gtgtcggggg tgggcggtgc cggcgaggag
     6601 ggcgagcaag gtggacttgc ccgcgccgct ggggcctacg accaggaggt gttcgccggg
     6661 ttggacggtg aggtcgaggt ggtcgaggac gggggtggcg tcggggccgt aggcgaaggt
     6721 cacgccgcgc agggtggcgg cggggggtgc cgggcgggtg gggcgaggcc ccagggtcga
     6781 gggttccgcg cgggacggct caggcacgtg tccggggccg gggagcgggg gcgcggggat
     6841 ggcggggccc tcgtccgccc tcccgtgcga gctggccccc ggcccgcgta cgcggtcggt
     6901 gacccccagc acgtcggcct gcttgccccg cacgtccccc tcttccccca gcagtcggtg
     6961 cagcacgacc agtagccgcg accccgccgt gcccagggcg gtgagcaggg cgttgacggc
     7021 ggggaggagg gcggtggtga cgtaggtgag ggctgcgagg agttcgccgg gggtgaggcc
     7081 ggtggggagg agggtggggg cggcgaggag gagggtggct acggggaggt gggcggcgag
     7141 gccgagggcg gtgacgcgga cggctgacca gcgggccagg gcggaggcgg cagtggcctc
     7201 ggcggtgatg aggggggctg cctcggcggt gaccgacggg gctgcgccgg tggcggcgat
     7261 gtcgcgggcg gcgtgatcgg tgcggccggc gaaggcggcg aggtgttcgt cggcgtcgag
     7321 gaggtcgcgt tggcgggcgg ccatggggcg gagggtggcg gcgaacaggg ccaggccggc
     7381 ggccaggggg atcaggacga gggggaggag cctcggggag agcgccgcca gtcccgtgag
     7441 ggcgccgacc gaggtgaaga ggaaggagcg caccgtcagc aggacgccgc cggccgcgtc
     7501 gcgggcgatc tcggtctggg cggtgaggcg ggagacgcgt gccgtgtcgg ccggggtggg
     7561 tgaggtggcg gcccgggtca gggtggcgcg gaccacgcgg cggaccaggg agtcgcgcag
     7621 gggttcgatc acgctgccga gtgagcggaa gaccccggcg tcggcgaggc ccccggtgag
     7681 ggctgcggcg gcgagggcga gcagccagag gaggcccgtg cggacgtctg aggcgaggaa
     7741 gccgtcgtcc agggcgcggg cgacggcgta gccggtgagg aaggtacggg ccgattcgag
     7801 gagggaccag gcggccagcg ccccgagcgg acccttgcgg cggcgggcga aggtgagggc
     7861 ggggcgcagg agggggcggg gcgtggcgcc aggggcatgc cggtcggtca tgtgtccgtc
     7921 tccgtgccga agaccgcgcg gtaggcgggg tcgtgccaga gggtgtggtg ggggcccgtg
     7981 ccgcgcacgc ggcccttgtc gagccagacg acctggtcgg cccgggcggc ggcggagagg
     8041 cggtgggtga cggtgaggcg ggtgccgggg gcctcggtga gggcgcggcc tacgaggtgg
     8101 gcggtgacgg tgtcgaggct ggaggtggcg tcgtccagga tcaggagacg ggtgggacgg
     8161 gtgaacgccc gtgccaggcc gaggcgttga agttcgccgc cggagagggg ggcttcggcc
     8221 aggggggtgc gggtgccgtg cgggaggcgg tccgtgaagg tgtcggcggc ggcgcggcgc
     8281 agcgcttggc ggaggtcggc ctcgggcagg gggccgcagg cgacggcgtc ggcgaccgtc
     8341 gtgccgaaga gggccgggcg ttcgaaggcg tacgcgacgg cgcggcgcag ggcgtcggcg
     8401 gagagggtgc gcaggtcggt tccgtcgagg aggacgctgc cctggtcggc gtcggtgagg
     8461 cggccggcca ccgccgccag cagggacttg ccggcgccgg acgggccgac gagggcggtg
     8521 gtggttccac cggggagggt gagggtgatg tcgtggagga gcggtatgcc gtcgcgggtc
     8581 acgtggaccc cgcacagggc gagggtgccg tcgccgtgcg gcgggaggtc gcgcgtcccg
     8641 tggggggtgg gcggcagggc ggtgacggtc tcgacgcggg cggtgcccgc cttggcccgt
     8701 acccagccgt tgagggcgcc ggccagcgct ccggctccgg cggcgaggac ggcgtagcgg
     8761 gagagggcga ggaggtcgcc gggggtgagg tgaccggcga cgaggcgtac gccgccgacg
     8821 gcgaggacgg cggcgaccag gagcggcatc agggcgccgg agaggccggc ggcgcggccc
     8881 tggacgcgcc aggtgcgctc gccggccgcg cgcatcccgg ccagcggggc gaggacgcgg
     8941 cgttcctcgg cgcgggcggt tccggcggcg gcgatggtgg cggcgccggt gagggcgccg
     9001 gtcagcaggc gggccatgcg gccctgttcc tcctggtacg tggtgagggc ggcgcggccg
     9061 tcgcggagca gggcgcgcag aatcatcagg aggagcggga cgccgcagac gaacgcggcg
     9121 ccggcccacg ggtcgacgag gaagagcccg gccagcccgc cgaggggggc gaggccggcg
     9181 gcggcagcgg tggcggcggc gacgggggcg gttccggcgt cgagggcgtt ggcggtgagc
     9241 cgggtgggca ggccggtgcc ggtcgtcgcg gcggggggcg cggcgaggaa gccggcgagc
     9301 gcgcggcggc gcagccaggc cgtggtggcg gcgccggtcc ggccgccggt gcgggcgacc
     9361 agggcgtccg tggccacctc ggcggcgatc agcgcgctgc acagcaggac ccagaacccg
     9421 gcgtcggcgc gggcgatgag caggtcgacc gcgcggccga gggcgagggg cagcgtgacg
     9481 gcggcggcgg cgccgagcac ggtggccgcg aggacgaggg ccgcgggccc cctgccccgg
     9541 cgtaccgcct cccgcagcag gcgcccctcg tcgggcggcg ggccgggagt ggcgcgggcc
     9601 cggtcggcgt cggcgggggc ggcggtcatg gctgctccgt tcgggcgggc gggcaggcgg
     9661 gcgggttgtc cgggagcggc gcggaacgcg ggaggtcccg ggcgctgggg cgcccgggac
     9721 caagggctgt cgcacgcgcc cggcccgtga gggccaggcg cgcggcggac agccgggttc
     9781 agctccgcgt cacggggtgc agagggtgac gctcagcgag ctgtactcgc agatgagcag
     9841 cgagatctgg ctgccggtgg cgaggtcgcc caccgcctcc tcctgcgggg tgtccatcgc
     9901 ctggaggtcg agaagcgcca tgacgtactc cttcgtgtcg agcggtcggg cgaccgccac
     9961 ctgggaaaac gagtggtgct ggtggtgcgc gaccctgagg tcagggccgg tctgtgggcc
    10021 gccggagcgg cgggaggaag ggcaggtgcg cggcgggttc gccgtgtgtc gcggccaggg
    10081 cgagcaggac gccggccgtg ccggtggaga ggtccatcga caggcgggtc aactgttctc
    10141 ctgggtaggc gagctgccct tcgtaggtga gcgcgtgcca gtccagcagg gcggtctggc
    10201 gggccaggag ggcggtgcgg gcggcccggt cgacgggggt ggtggtgcgg gccaggtgga
    10261 ggaggagtcc ggccacgccc cggaagaggc cgggctggat gtagaaggcg gagccggtgg
    10321 cccgcaggag ggcggtccgg gcctcctcga aggcggggtc ggggcggtgg gccaggtagt
    10381 cgtcgaggac catcgcgatg cccgcgctcc cggagccgag gtatggcatg gtccgccggg
    10441 cctcggagac gacgagcgag ccgtccggtc ccggcacgca gcggctcagc tcctggcgga
    10501 gggcggtggc ggcggtgtcg agcagggcgg gttcgccggt acgggcgtgg cggcgcaggc
    10561 agagcagggc ggtgccggcc gggccgtgca gcagtccggc cttgccgccg ggggcggcgg
    10621 agcggagtgc ggcggcctcg gcgcggccgg cggccttgcc gagggcgggg tcgtcggcgc
    10681 cgtcggccag gtcgcgcagg gccagggcga cgccgggggc gccggagtgc aggccgggcc
    10741 cgagtgcgtc gaggggttcg gcggcgacca ggtgggcgag gcgcagggcg tcctcacggt
    10801 ggccgaggcg gtccagggtc caggcgatgc cggtgaggcc gtcgtagaag ccggccgggg
    10861 tgcccgaggc gggccggcgg gtggtgcgga tcagccattc ctcggcctcc tcgcagcggg
    10921 cgccgacggt gtgcagggcg tgcaggacgc cggcggcgcc gtagccgtac gactgtccgc
    10981 cggccggggt ggcgaactgg gcgatgtcgc ccgggaagta gcggtcgtcg cggtcggggg
    11041 tggcggaggc gagcagggcg gccaccatcg agtcgcgggc ggcgggccag tcggtggcgc
    11101 tcaccggcgg gcggccacgg ggtgtcgcgg cctccggcct tgccgggccc gcgagttcgg
    11161 tgaccgcctc gtcgaagagg gcacggtcga tgccgtaccg gtcggcggcg aggtcggcga
    11221 ggtgggccgc cttgtcgcgg tcgaggggca gcagggtggt gagcgggacg aagagggcga
    11281 ggcggaggca ggccagggcg taccggtcga cctctgtgcc gcgcaggtgg ggcggggcga
    11341 cgaaggcggg attggcgacg atctgcgggc ggcgctcggc ggccggggtg gcggcctcga
    11401 agtccagcag ggtgacggag agctggtccg gcgccaccat gatgttgttc atgtgcaggt
    11461 cgccgaaggc gatgccccgg gcgtgcagcg cctcgaccgc ctccgtgacg agctggtggg
    11521 tgcgcagggc ccaggcggtg tgctcggcga gggcttcggc ggccggctcg gcggcggaga
    11581 gcgggaagcg gcgggcgaag accgtgttga gcggggtgcc ggggatgaac tccatggcca
    11641 ggaagcggtg ttcgcccacg gtgtgcagtc cgtgcacgcg cgggacgcac gccagccctt
    11701 cgagggcgcg cagggccgcg tactcccgct ccagccgggt gaccgcgtcg gccccgtcgg
    11761 cggcgagccc ggcgtacggc cggccctcct tgagcaccac ggcctcaccg gtctcccggt
    11821 gcgaaccggc gtacaccccg cccccgttgg agaagtgcag ggcgcgttcg acggtgtacg
    11881 ggaggccgtt cgtgccctgg gcggcgcggg cctcggcgtg cgggcgcagg aagtcgggga
    11941 gtgccaccca gtcggggagg cggaaggcgg ggccgcgggt gtccgggacg aggcggcccg
    12001 tcgggtcggc caccgccggg accagggagc cgtcggcggt gcgggtgaag cggggcgcga
    12061 aggcgccgta gcggacgtgg accgggccct cgccccagcg caggtcgctg aggacgaccg
    12121 ggcccgcgct gcccttgagg gcgtccgcga gctcggcggc cagttcgccg caggcggcgg
    12181 tggtggccgg gtagacggtg acgaacttgc cgctgccggc gcggtcggcg tacttggtgt
    12241 tgcggtggag cagcagggcg ggcccggcga ggaacttgaa ggcggtggcg cgctcctggc
    12301 agatcccggc gacggtctcc aggacctgct cggcgttgtc cggcgtcgcg gagacgtgga
    12361 tcttccagcc ctgggcgggg agctggcgcc cggcgggggc gagcgagaac cagtcaccgc
    12421 gctcggcgct ctcccagccc ccgggggcgg gccgcagggc gagggcgtaa cggtggccgt
    12481 cgttgccgtt gccgtcaccc gcacggccgg cccggcgcgg ggtgtcgtag aaccagcggt
    12541 cggcaccgct gtagagcgcg tactccggat tcaccggtcc ccctcgcctt ctgcgttccc
    12601 gtgccgtgct gtgcgtcgat gacgggttcc acactgcccg tggccgggcg gcgccggtaa
    12661 gtaacgcttg tcatcggcga gttgtgggaa acgcatggtc cgaacgggtc atggcggacg
    12721 ggctcggagc gtgctgcggg gggccggtgg ctgccggagc gagggcggct caggaggggg
    12781 tcagggcctc ctccagctgg tccaggatct gctgggcggc ggtgtaaccg atgccctgga
    12841 tccacagctc gtcctcgacc ttgtggacgg cgccggactt gacggcgtcc agggagcgcc
    12901 agagggcgga cctggtggtc cgcgtctccc tggccttctc cgggtcgccg taggtggcgg
    12961 tgaagaccac gtcggcgtcg gccaggtcga tcttctcggg gctcacgtcg tacgagaagc
    13021 cgtcagcggc cttgtcggtg acggcggggc ggccgaggcc gacgtcggcg aggagggtgc
    13081 cgatgtagtt cttcctgccg tagatgcgga tgtcggctcc ctcgacgaag cggaccacgt
    13141 tgacctcggt ctccttcgcc ttcgccgggc cgccgaccgc ctcggtgacc tcggcggtcc
    13201 gcttctcgta ggcggcggtg gcgcggtcgg cctccttctg cttgccgagg gcctcggcgt
    13261 gcagctggaa gttctccttc caggggtagc cggtgttctc cgtcatcacg gtggcggcga
    13321 tcttgctgag ctgggcgtag cgggcctcgt cgcggacctt cgaggtgagg atcaggtccg
    13381 gcttgagcgc cgcgatcgcc tccaggttgg gctgggcgat gacgccgacg ttctcgatcc
    13441 cggccagttc cctctgcggc aggtagcccg cgaacccgcc ggcggcgtcg gagcggacgg
    13501 cgccgaccgg cttcactccg agggtgagcg cggagtccag ctcggcggtg tccaggacga
    13561 cgacccgctt cggcgcctcg gggacctcca cctcgcccat cgcggtcttg acggtacggg
    13621 tggctcccgc gtccttgccc gcgtcggcgg cggtctcctc gccggagccg caggcggtga
    13681 gggtgacggc gagcgcgagg gcgccggtgg cggcgaggag cggacgggcg gtacgtcggg
    13741 tcatggcgtg gccctgcttt cttctcgggt gggggcagcg ggttccggcg ccggctgccg
    13801 ggcgtcccag ggcgcccccg ggacgacgag cggggagccg gtgacggggt cggggacgac
    13861 gacgcactcc aggccgaaga tctcccggac caggccggcg gtgacgacct cggcgggggc
    13921 gccctcggcg acgacgcggc cctcccggaa ggcgatgagg tgatccgcgt agcgggcggc
    13981 ctggttgagg tcgtgcagga cgaggacgac ggtgcggccc tgctcgcggt tgaggcggcg
    14041 gaccaggtcg aggacctcga cctggtgggc gaggtcgagg taggtggtgg gctcgtcgag
    14101 caggagcagg tcggtctcct gggcgagggc catggcgatc cagacgcgct gccgctggcc
    14161 gccggagagg gcgtccacgg gacggtcggc gaggtcggtc gtggcggtgc gggccatcgc
    14221 ctcggtgacc gcccgctcgt cctccgccga ccactgctgc caccaccgct ggtgcggctg
    14281 gcggccgcgc gccaccaggt cggccacggt gatcgcctcc ggtgccaccg gggtctgcgg
    14341 cagcagcccg atccgccggg cgatctgccg ggtgggcagc cgggccagtt ccgtgccgtc
    14401 gagcaggacg gcgccgccgg cggggcggag cagccggccg agcgcccgca gggtggtgga
    14461 cttgccgcag gcgttgggcc cgatgatgac ggtgacccgg ccgtcgggga cgtccaggtc
    14521 gaggccgggg acgacggtgc ggtcctcgta ggcgagggtg aggtctcggg cggtgaggcg
    14581 ggcggcgggg cgggtcatga ggtgcctccg gtggcgcggg ggccgtgtcg ggtgacgagc
    14641 agccagatca ggtacggggc gccgaccgcc gcggtgagca cccccaccgg cagttcggtc
    14701 ggcgcgaaga ggcggcgggc cagcaggtcg gcggcgacca cggtgacggc cccggccagc
    14761 gcggagcaga ccagcgggat ctgcgcggta cgggtcagcc gccgggcgat ctgcggggcg
    14821 aggagcgcga cgaagtcgac gggcccggcc gcgccggtgg cgaccgaggc gaggaccacg
    14881 ccgatcagga cgagtccgag gcgggcgcgt cccaggtggg cgccgagtcc cgtcgcggtg
    14941 gcgtcgtcca gggtgacggt gcgctggacg cgggcggccc agaccagcgc gggcagggcg
    15001 gcgagcaggg tccagccgac gagggcggct tccggccagg cgcggccgtt gagggacccg
    15061 ctcatccaca cctgggcctg ctgggccacg gtctggtcgc ccttggtcag gaagagcgtg
    15121 gtcagcgccc gcagggccac ggcgaaaccg accccgacca gcacgaaccg ggtggcctgg
    15181 agcccgcccc gccaggcgaa gaggtagacg agcagcgccg cgaggagccc gccgcccagg
    15241 gagatccagg gcagcacggc gtacgaggtg acgccgaagg tcagcgcggc gaccgtggcg
    15301 gcgctcgcgc cctggctgac accgatcagg tccgggctgg ccagcgggtt ccgggcgacg
    15361 gtctggatga gcgcgcccgc gatcccgaac gccgccccga cgtacagccc cgccaccatc
    15421 cgcggcagcc gcagctcccc caccaccagc gtgtccggcg agggacgccc cagcagcacg
    15481 tcgaccaccg acccgggcgc gacgaagctc tcgcccacac tcaggtacgc cacacagacc
    15541 acggccagca cggccgccag gacggcgccg gtcgcgaccg cccgcacggg gacgagaaga
    15601 ctgacggccc ccagccgtac ggggacgtac ccggcggggc gtacgcgggc ggggaccggc
    15661 cccgccttca gcacctgccg ctcacccggt caccaccctg ccccggacca gcgccaccag
    15721 gaagggcacg ccgatcagcg ccgtcatgac cccggcgggg acctcgcccg gcgggaagag
    15781 gacgcggccg acggtgtcgg aggcgaggag catcacgggg ccggtcaggg cggccagcgg
    15841 gaggacccag cggtggtcgc cgccggccag gtggcggacg aggtgcggga cggcgaggcc
    15901 gacgaaggcg accggcccgg cggcggccac cccgaccccg gtcagcacgg cggctccggc
    15961 ccccgcggtg atccgtacgg ccccgacccg ctgccccagc cccttcgcca cgtcctcccc
    16021 cagcgccagc gcgtccagcc cccgcgccga ggacgccacc agcgccagcc ccaccagcag
    16081 gaacggccac acctgcacgg ccacctcggc gtcccgcccc tggagcgcgc cgacgttcca
    16141 gaagcggaac tcgtccaggg cgctggaact ggtggtcagc acggcggtgg tgaccgagac
    16201 cagcagggcg ttgaccgcgg cgccgctcag cgccagcttg accggggtcg cgccgccccg
    16261 gccgcccgcc gcgaccgcgt acacggcgac cgccgcgagc cccgcgcccg cgaaggcgaa
    16321 ccagacgtac ccggccaggg tgtgcacccc cgcgaaggcg atggccagga cgaccccgac
    16381 cgaggcgccc tggctgatgc cgagaatgcc cgggtccgcg atcggattac gggtgatgcc
    16441 ctgcagggcg gtcccggcga cggcgagggc ggcgccgacc atcacgccga tcagcgtgcg
    16501 cggcagccgc atctcccgga ccacctcggc gtccggaccc gtggccccct ggaacagggc
    16561 ctccacgacc gtgccggggg ccaccgtacg agcgccgaca gccaggctga ggacgaccgc
    16621 gaccagcagc gccaccaggg ccgccaccgt ccaggccgcc cggtgtacgg cgctgtcccg
    16681 gcggggccgg gaggctgggg gcggtgcctt cgccaggggc ggggcggcgg gcggtgcggg
    16741 gggcatcggg tcctttccgg tccgggctgt ctccgggccg gcggccggga gcggacatga
    16801 cggcacaccg ccccaattgc ccgttccgcg acggcactta ggcttggcta agtgtacggc
    16861 cgtcggggct gcacaatgga gggatgcccg agcacctcac ctcccccgcc gcgcccactc
    16921 cctccggccc cgccgtaccg gccgcacgtc cggctccggg cggggccggg cccgtcgtcg
    16981 ggttcgacct cgacatgacg ctgatcgact cccggccggg gatcggcgcg gcctatcgcg
    17041 tactcgccgc cgagaccggc gtccccatcg acgtcgacct ggtcgtctcc cggctcgggc
    17101 cgccgctgga gaccgagctg gcctgctggt tcccggccga gcaggtcccc gccgccgccg
    17161 cgcgctaccg cgaggtctac ccgtccaccg cggtagcccc ctcgctcgcc ctgcccgggg
    17221 ccgcgcaggc gctggaggcc gtacgggccc acggtgggcg ctcgctggtc gtcaccgcca
    17281 agaacgagga gcacgcgcgg ctccacctgg accacctcgg cctccgggcc gagctcgtcg
    17341 tgggcagcct ctgggccgag gccaaggggg gtgcgctgcg cgcacagggg gccaccgtgt
    17401 acgtcgggga ccacgtcggc gacgtccgcg gcgcccaggc cgccggggcc ttctccgtgg
    17461 ccgtcgccac cgggggctgc acccccgacg agctccgggc cgccggcgcc gacgtcgtcc
    17521 tccccgacct ggccgccttc cccgcctggc tggcggagtt cgcccgctga cccgcctcat
    17581 gcgccggctg ggccgctctt cggctggacc cggtttgccc cacaccggtc aaggacggcc
    17641 tcaaacgccg gccgggccat agggtttcgc ggtgcgttcg ccgtcctggc cgggcggggc
    17701 cgcaccgccc cgaaggttcc cgtcggagcg gggcggcccg gccggaccgg cggcacacac
    17761 cccgtcgagg tcccgggcca gctcccggaa gtcacgccag tcctcgggct cgaccccgcg
    17821 cagccgcagc ttctcgccgg cccagacgtc cgccacgacg cccccggctc cgcatccccg
    17881 acgggcactc gggaccggcc cgcacgaccc cgccacggta ccggcgcccc gccccgcccg
    17941 ggccctgcgt accggcggcc cggcccgccc gcgtaccgtg caacccccgc gcccaggtcg
    18001 gccgcgcccc gaacggggta ggcacccccc gacccgtagg gcaccgggtg ccgcgaggag
    18061 gaacgatgaa gcaaccggct cggacagcgg gcggggccgt ggccgaggag gcgcggccgg
    18121 tggagggtgt cgagggggac gagccagggc gggcggcaga gtggtgggtg gcgttgcggc
    18181 ggacgccggg ggcgttctgg cgggacgacg tctcggactt cgcggcggcg ctgacctatt
    18241 acgcgatcct cgccgtgctg ccggcgctgc tggtggtcgt gatcgctttc gggctggtca
    18301 gtccggacac ggcggagcgg ttcgtgggcc aggtgacggc gtgggcgccg ggcggctcgg
    18361 gggcctcgtt gcgcgaggtg ctgacgcggg tggtgcgggt cgactcgacc gcctggacac
    18421 tgctggtgac cggcggcgcg agcgcgctct ggtcggcctc cagctacctg gcggtctcgc
    18481 ggcgcgcgct gcaccgcatg tacggggtac gggaccggcg ttcgccgtgg ggcaaggcgc
    18541 accggatcgt ggcgacggcc ctggccctgc tgtcgctgct gctggtcagt tcgctgctgc
    18601 tgatgctgac cgagccggtg gccgagtcga tcgggcggct gctggggctg gacgccgggg
    18661 tggcgtgggc gtggagcgtg gtgcgctggc cgttgctgct ctgcctggtg gcctgtctgg
    18721 tcgtggtcgt cttccggaac ggcccggcgg ccgcccgccg ccgcgcccac agcatccccg
    18781 gcggcgtcct cgccgcgacg ctctggctga ccgcgtcggc ggggctcgcg ctgtacgcct
    18841 cggtgctcag tacgtacagc cgcctctacg gctcgctcgc ggggatcgtc gtcttcctgg
    18901 tgtggctttg gctctccaac gtcgcgctgc tgctcggcgc ccagttcacg gcggagttgt
    18961 gccgcgcgga ggggggcccg ggcgcaccgg cctgccgccc cgggccggtc gagggcatgg
    19021 ccgccgagga cgtgccggcc gacaccgacg ccgcccagga gcacgggcgc gcccccaccg
    19081 gcgcgtgatc cccttccgcc tttcgccctg gcgggggcgt cccgcaccgc atgagggcaa
    19141 ggcgggtgat tccccgcaga gggtgcatac atcccgccag gagctggcct gaactggccg
    19201 cttgacatat gacacatggt cagttgggcc ctatccatga ctccctggcg accgttactt
    19261 tacaaagtgt gattactgaa cgagagattc cgctccgcca cagctccatc tccgcctccg
    19321 cttccgtcgc cgacgacctg ctcttcgcga cacgcggcga agagcacctg cgctggcggg
    19381 agctattcag cacggaggag ttcggccacc gggacttgcc ccaccgggaa agggtggagt
    19441 tgtcctatcg gcgcttgcgt accgtcgccg ccgcgatacc cgatccacgc gcgctcgccc
    19501 tgagcgcgcc ggcgctgacc gcgctccacg agtgggcggg cccggccgat cccgggatgg
    19561 ccacgctggc ctccatccac tacaacctct tcctgggcag cctcctcgac cacgatcacg
    19621 cggagcggga cctggggccg tggctgcgga tggaccggat cggcacgttc ctgtgcaccg
    19681 aggccgagca cggcaacgac gcggtgaaca tggagacgac cgccgagtac gaccgcgcct
    19741 ctcgtcagtt cgtcctcaac accccgggcc cgggggcggc caagtggatg cccaacacct
    19801 cgctgaccgg cggcccgaag gacgccgtgg tggcggcccg gctgctggtc gacggccgcg
    19861 acctgggcat cttcctcttc ctcaccccgc tcagcgacga gcgcggccac ctgccgggcg
    19921 tcagcgtcga gcggctgccg cacacgtccg gcgcgcccgt ggaccactgc gccacccgct
    19981 tccaccacgt gcggctgccg cacagcgcga tgctccaggg cgaccacggg cggctgagtc
    20041 cggagggcga gttcgagagc acgctcggga gcccccgtat ccgcttcctg cgctccatcg
    20101 gccgggtgtc gatgggcaag ctctgcatgt ccggttacag cctgggcgcc acccggcagg
    20161 cgatcgcggt cgccgtgcgg cacggctcca cgcggctgac ctccggcatg accaaggggc
    20221 gcagggtccc gctgatggcc caccgcagcc accacgagcc gctgctcgac gcgctcgcca
    20281 ccacgtacgc ggcgacgctg ctgcaccgct cggtggtacg ccagtgggag gtggccgagg
    20341 aggccgagcg cgaggaggtc gaccggctgg tcgcggtgac caaggggtgg atcacctggg
    20401 cggcccggga gaccatgacg acctgccgtg agcggtgcgg cgccaagggg ctgctgctga
    20461 cgcagggcat cgcgggccag ctcgccgcca acgagggcac catcaccgcc gagggcgaca
    20521 acaaggtcat ctgggtcaag gccgccggtg agctgctgat gggtgggttc accccgaagc
    20581 cgcccagcga gaccgcgccc gagcagcggt ccctgcggga cggcacgcac ctccaggacc
    20641 tgatggcgga cgtggagcgg atctggcacg agcgggcccg gacccggctg cgctcgggcg
    20701 gcgtacgcgg caacccgatg gcccgctgga acggcgccgt caccccggcg ctggagctgg
    20761 tcgccgccca cgcgcaccgg ctggccgggg aggcgctgct ggagggcacc gaccgggtca
    20821 gcgccgacga ggccgagcgc atccgcgacc tgcaccggct cttcgcgctg cgccaggtgg
    20881 cggcgcacag cggggagttg ctggccggag agcggctgac ggcggagcag gtgcggcggc
    20941 tcccggacga ggtcgagcgg gtcgtggcgg acctggagcc ccacatcctc gccctgacag
    21001 aacgtttctt cgtaccggag aacctgcccg gcagcgaccc cgccggcctg gtcgaggccg
    21061 cgcccgaggc cctcgccgcc ggcacggagg cccgtaccgg cggactccgg gagagcgagc
    21121 cggacgcggc atgacgggct gaggcgaacg aaggcgtgac gcgggacggc ccgccgcgcg
    21181 tgggcacgac gggccgtcct tgcgtctccc gtcctccggg cggcacaccg gccggaggcg
    21241 tttgggtcag acccggaaga tgtcgaggaa ggagctccag aagcccttcc tgcgaccgcc
    21301 gccgtccgag gaggccgggg cggtgtgctg cggctgcggg gtggcgggtg ccacctgctg
    21361 ctgcgggacg ccccggctct ggagggccgc ggccatccgg gtggccggag tcgggctgaa
    21421 ggcgaccggc agcgagacca gagcccggtg gaacgggccg ggccgccact gcagttcctc
    21481 ctccgggacg ccgagcgtca ggtccggcag ggcgttgagg atcttctcga ccgcggtgac
    21541 cgcgatgacc tgcgccgggt ccttggccgg gcaggcgtgc gagcccgcgc cccaggcgag
    21601 gtgggcgccg cgtcccgcgc tgcggcgggc ctcggcgagg gcggggtcgc tgttggcccc
    21661 ggcgaaggag atcaggacgg ggctgccggc gggcgcgatg acaccgttgc cgaagtccgt
    21721 gtcctgggcc gggtagtggg cggcgtagtt ggcgatcggg gtgcggtgcc acaggacgtg
    21781 gtcgaccgcc tcctcgacca tcatcccggc gccccggccg cccgcgccgc cggagagcag
    21841 ctccagcagg gcgttgccga tgaggttgcg ctccggctcg atgccggcgc ccatcaacat
    21901 caccagctgg tccttcagct cctcgtcggt cagcccggcc gggtgctgga tgagccagga
    21961 gatgacgtcg tcggccggct cgcggcgctt gatcgcgatg agctgcatca ggcaggcgtc
    22021 gaggcgggcc ttggtccgca ccgggtcctt gccgtcgaac atcgccgaca tctcggtggt
    22081 gagggtgtcg ccgatctcgg ccgggcagcc gaagagcttg ttgaacagca gcagcgggag
    22141 cagcttggcg tactccgcga ggaggtcggc gcggccgcgc tcgctgaact ggtcgatgag
    22201 gtagtcggcg atcggctcca cgtcacggcg gatgcgcgtg atgttgagct tggcgaggct
    22261 gtccgtgacc gccttgcgca gccgcaggtg gacggcgccg tcggtgaaca gggcgttcgg
    22321 ccggtacgcc atcatcggca ggaccgggct gtccatcggg acgcggccct cgttcagggc
    22381 cgcccagcgg cgggcgtcgc gggggaagct cgtcgggttc tggagaacgc gcaacgccgt
    22441 ctcgtacccc acgaccagcg tcgcgtcgac tccgggggcc agctcgaccg ggccggccgg
    22501 gccctgctcg cgcagctgct cgtagaccgc ctgggggtcg gcggcgaagt tggcgtcgtg
    22561 catcgggcat ctgc
//
