LOCUS       NZ_CM002273            21725 bp    DNA     linear   CON 11-AUG-2024
DEFINITION  Streptomyces sp. PVA_94-07 strain PVA 94-07 chromosome, whole genome
            shotgun sequence.
ACCESSION   NZ_CM002273
VERSION     NZ_CM002273.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. PVA_94-07
  ORGANISM  Streptomyces sp. PVA_94-07
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Draft sequence of Streptomyces sp. PVA 94-07, a marine actinomycete
            isolated from the sponge Phakellia ventilabrum collected in the
            Trondheim fjord (Norway)
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7007517)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Assembly Name                     :: PVA94-07.23
            Genome Coverage                   :: 158.81x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495755.1-RS_2024_08_11
            Annotation Date                   :: 08/11/2024 02:29:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,173
            CDSs (total)                      :: 6,079
            Genes (coding)                    :: 5,859
            CDSs (with protein)               :: 5,859
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 220
            CDSs (without protein)            :: 220
            Pseudo Genes (ambiguous residues) :: 0 of 220
            Pseudo Genes (frameshifted)       :: 97 of 220
            Pseudo Genes (incomplete)         :: 166 of 220
            Pseudo Genes (internal stop)      :: 15 of 220
            Pseudo Genes (multiple problems)  :: 55 of 220
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 00:06:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1862907
            Orig. end                         :: 1884632
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CM002273.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Department of Biotechnology,
            Norwegian University of Science and Technology, 7491 Trondheim,
            Norway.
FEATURES             Location/Qualifiers
     region          1..21725
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="11"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21725
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21725
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11725](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11725)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(1024..1770)
                     /locus_tag="B590_RS07660"
                     /old_locus_tag="B590_07775"
     CDS             complement(1024..1770)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029046.1"
                     /locus_tag="B590_RS07660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07775"
                     /product="site-specific DNA-methyltransferase"
                     /protein_id="WP_023416946.1"
                     /transl_table=11
                     /translation="MSYTLHRGDALAVLKSLPDESVQAVITDPPYNSGGRTSSDRTGRT
                     ARAKYVTSNSAHDLANFPGENRDQRSYRSWLTELLTEAYRASTEHAVAMVFTDWRQEPT
                     TSDALQMAGWTWSGTIPWIKPSSRPRKGGPKQDSEFIIWGVKGSLDNTRDLYLPGHYIA
                     SQPRKGRVHITQKPVEVMQQLVQVCPEGGTVLDPFTGSGSTGVAALREGRRFVGVELSA
                     HYADVAEERLRAELTKDDFELAGPEA"
     misc_feature    2217..2233
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.77"
                     /tool="antismash"
     gene            2349..3494
                     /locus_tag="B590_RS07665"
                     /old_locus_tag="B590_07780"
     CDS             2349..3494
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153410.1"
                     /locus_tag="B590_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07780"
                     /product="C40 family peptidase"
                     /protein_id="WP_023416947.1"
                     /transl_table=11
                     /translation="MKKTTGALVGLCATGPLLLALPILGIGAGTASASCSTDGAQGVDA
                     SAVAKQVKAILDGGDKGSVSVPGLDAPADQVPNAKTIQATGVAMNIPARGQVVALATAL
                     QESGLRNLTYGDRDSLGLFQQRPSMGWGTASQILDPVHASTKFYEGLKKVSGWQSLSVT
                     QAAQAVQKSGFPEAYAKWEPLATALQKAIEPLLQNAGGASPSPSPSGSADTGSPSPDSA
                     GGCSADGDGTDFGTIPAGALPDEYKIPASAPPKVQTAIRWALGQLGTPYQWGGTCTDSH
                     GKNPMGRCDCSSLMQGAYKAAGVTLTRTTYTQVKDGKAVSVDALKPGDLLFTEGTAAVP
                     EHVGMAIGQGLIVHAPHTGDVVRITTVASWKSRILAARRVV"
     gene            3742..4994
                     /locus_tag="B590_RS07680"
                     /old_locus_tag="B590_07795"
     CDS             join(3742..4024,4024..4994)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1164: transposase
                     IS3/IS911 family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_086558251.1"
                     /locus_tag="B590_RS07680"
                     /note="programmed frameshift; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="B590_07795"
                     /product="IS3 family transposase"
                     /protein_id="WP_255219929.1"
                     /ribosomal_slippage=""
                     /transl_table=11
                     /translation="MARPSSYPVELRKRAVRMVAEVRGDYPNESAAVRAVAQKLGIGSA
                     ETLRNWVKRDEVDSGKRPGTTTEESAQIKAMKKEIAELKRANDILKAAAKFLRGRARPA
                     THTLVAFIDEHRARFGGVEPICRVLTEHDCKIAPSTYYAHHKRLQDPSARTVRDAELKP
                     LIREIFEVNYRVYGARKVWRELHRQGHVVARCTVERLMRELGVTGAVRGKKIITTIPDS
                     SVERAPDLLDRNFVAPAPNRCWVADFTHISTWSGVVYVAFVVDTFSRRIVGWSAATSKE
                     TRLVLDALDMALWQRDRDEQPYQEGELIHHSDAGSQYTSFRLAEHLDAAGIAASIGSVG
                     DAYDNALMESTIGLFKTELIKPGRPWRTLSQVELATAEWIDWYCHRRLHGEIGHIPPVE
                     YETNYYLTSTKPQVTTTT"
     gene            <5016..5225
                     /locus_tag="B590_RS33300"
                     /pseudo=""
     CDS             <5016..5225
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972945.1"
                     /locus_tag="B590_RS33300"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF6112 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GSINLFGLIAVVGALAVSAGVWAWGHHSGGHQAEANGKKGVLVSA
                     GAALLLGAANGVVAFFSTLGTQVH"
     gene            5225..5905
                     /locus_tag="B590_RS07690"
                     /old_locus_tag="B590_07805"
     CDS             5225..5905
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327558.1"
                     /locus_tag="B590_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07805"
                     /product="hypothetical protein"
                     /protein_id="WP_023421642.1"
                     /transl_table=11
                     /translation="MAQHSTHPGGASRVRRRALLGTAVLAVLVALAGLAAYLTREGRSP
                     SDTASPPPSSPTASSSPAAPSGPHTRPRALPVPPKTHDPITYGKAAAAALWSYDTRAYS
                     QAELRKALRGWLTTESKYADPASVDQAVPSAVLWKEMAANKQVATAKINEGHFPHTFTQ
                     ALQDDPGAITQAYVYAVTVSGKQSIRWKGSTAGGAESRSTTLAVQCRPNHPCALVGVMP
                     SVAP"
     gene            5934..7343
                     /locus_tag="B590_RS07695"
                     /old_locus_tag="B590_07810"
     CDS             5934..7343
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011029050.1"
                     /locus_tag="B590_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07810"
                     /product="ATP-binding protein"
                     /protein_id="WP_023416951.1"
                     /transl_table=11
                     /translation="MGVCDFPLMDKVCGAVDFATNPAGTVTDGLGAWIAKSAGELASSA
                     ADLAAKAVNKTTAIDLNAGWFRDNYELLLPIGLALTVGIFCIQLMTAAWRRDERALAKA
                     AFGTMTGVLFSFSAIAFTTVAITVVDALSDGLFKAANTSIDDAIRRVIKVDQMGAMYGL
                     GWGVPALVAFGCAIGAFLYWGVMVARKVGVLIMVALAVFAGAGGGWEVAKRWRRGWIEA
                     TGTLIVSKLLMTVVFLIGVSAMGKTDASDGMAALSDAMAGIVVMVLVLLCPYATYKFVH
                     WASDGGGHDDMHRTGVAGMAVASGAAKTAGSLAMRASTGTPAPQGPNQVPGAGTDGVAS
                     GINPSGGNLSKEGIDAGPPKQQTRFRYGEDPDASGDKGRALIQRPGIPPLITRPGEDEP
                     EGSESTAQGVAGGSGHLAAASAPGGDMTSMPPADPGPSASGTPASASGPSATGSATPTN
                     WVYPTQPPSGS"
     gene            7475..8941
                     /locus_tag="B590_RS07700"
                     /old_locus_tag="B590_07815"
     CDS             7475..8941
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972948.1"
                     /locus_tag="B590_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07815"
                     /product="SCO6880 family protein"
                     /protein_id="WP_023416952.1"
                     /transl_table=11
                     /translation="MSGKHQSSTPTVKFPHRSRRGVLLGLSVPQLVVAGLTGLLLLAVI
                     LARGVVGALQFIPLWAVIALLVFVRHRGRALADWAPIVVRYALRRMRGQLVWLTRPSRR
                     PTREGLLHLPGTAASLRVTTAPDGKYGAVHNPHTGTLTVVVKVSSRAYALLDPGTQQAN
                     VGGWGRALAALARTGQIARIQVIERTIPDSGDALRRYWEEHGRPDTPMAGAIYNELIQS
                     AGPAAAPHEAYVAVSLDTKAARRLINQAGGGLTGAFSVLAQLTSTFDQAARTAGLTPTG
                     WLTAREIAAVVRTSYDPKALATLDRWSTAGRPEAEPAAAGPVVVVERADHIATDSAVHA
                     TYWVENWPRTETSAGFLHQLLFTGGVRRTLSLSYEPKNLDAALRDVQRKKSSVIADAAE
                     RARRGQVDSEADSIEYQDIKSRERQLIAGHADVALTGLLTVSADTEDDLRTACAVVETA
                     AVGAQLDLRPLTWQQAEAFTAAALPLALAA"
     gene            8971..9423
                     /locus_tag="B590_RS07705"
                     /old_locus_tag="B590_07820"
     CDS             8971..9423
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143503.1"
                     /locus_tag="B590_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07820"
                     /product="DUF6238 family protein"
                     /protein_id="WP_023416953.1"
                     /transl_table=11
                     /translation="MSRTASPTAQDFVPFATAALDFHRALNIPGGPLVTTRAELDTLHA
                     HLISLYGLLDAHASRTGQLVAVEGDQLRTARTRIWQAAEHLHAAYHAAPRPDSGEIPAP
                     EACQAGLPEGAPELTICQRHQRTAHLVRRRTTPADLHAPFTGLVRR"
     gene            9450..>10043
                     /locus_tag="B590_RS33305"
                     /pseudo=""
     CDS             9450..>10043
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016327556.1"
                     /locus_tag="B590_RS33305"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPRTRASASPLFVPRKTTRAEQRAARAGFTEARRQARLAGSPPKH
                     RAEQTLDPDLRPTYPLSGRPGPASARGGKLALPAHRMTTATASGAYPFVAEGGLGAEGV
                     FIGRDVHAEAAFCFDPFSLYNSGRVEGFTNPNAVLAGIIGMGKSALAKSIATRSIAHGY
                     RIYIPCDPKGEWTAVSQALGGYSIALGPGLPGRLN"
     gene            complement(10001..11725)
                     /locus_tag="B590_RS07710"
                     /old_locus_tag="B590_07830"
     CDS             complement(10001..11725)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="B590_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07830"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_369679373.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-147,
                     bitscore: 490.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.1e-16,
                     bitscore: 59.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASRAAAGYLWQGVAMLRATTSPGPADIPRTLDLDNVAVTRGWLN
                     RIWQREDFRRALELATPVLSDAIEAVVRGRQTEPRQVRRTALSTVSYLLRWQHRPTPLG
                     LFAGIAPVSVGPRASARWRDKHRAVIRPDAEWVTDMVLRLQRTTALLKRLPVVANNAAR
                     ARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAMEAACTPVPYSGLHGDLRARFPQ
                     AAPEKIDALLASLVEQQFLITSLWAPMTTVDAFQHLCHELDRLQADSIPEVRDLVHELY
                     ALRDELSAHQPTLSDTSVSTVATRMRALTPVTPTPLLIDTALDCETTLPQSVIAEAQAA
                     VSALYRTTPQPYGYQHWRDYHRRFRARYGVGALVPVMDLVADSGLGLPAGYVGSERGAA
                     LKVRTDRDELLLAMMQQVLLGGGRELRLTDDMVDALEKAAGKDERLFVPRVEVAFEVHS
                     SSTRALSSGAFDILLTAVPRPGSSMAGRFAHALPPEHQDALAATYHGAPHSLTAQLVFP
                     PRRHRNENVTRTPRLLPHVIELSGHQKTDETTIPLADIAVIADRFNRPGSPGPRAML"
     aSDomain        complement(10982..11260)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_B590_RS07710_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="5.20E-19"
                     /identifier="RREFam001.1"
                     /label="B590_RS07710"
                     /locus_tag="B590_RS07710"
                     /protein_end="248"
                     /protein_start="155"
                     /score="59.7"
                     /tool="antismash"
                     /translation="VVANNAARARGDRLVAPGPPSDGHAVLLAPVEISVRNARPVAAAM
                     EAACTPVPYSGLHGDLRARFPQAAPEKIDALLASLVEQQFLITSLWAP"
     misc_feature    complement(11264..11266)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11817..12014)
                     /gene="fxlA"
                     /locus_tag="B590_RS07715"
                     /old_locus_tag="B590_07835"
     CDS             complement(11817..12014)
                     /codon_start=1
                     /gene="fxlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012380187.1"
                     /locus_tag="B590_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07835"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_023416956.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 1.7e-14, bitscore:
                     51.9, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSATLAPPPVAPAADLEDDFAPLDVKVVIAEHSYGHLMCSTGDG
                     CGTTCATGASACGSFTEDPA"
     gene            complement(12067..13305)
                     /gene="fxlM"
                     /locus_tag="B590_RS07720"
                     /old_locus_tag="B590_07840"
     CDS             complement(12067..13305)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018490583.1"
                     /locus_tag="B590_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07840"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_023416957.1"
                     /sec_met_domain="PCMT (E-value: 2.5e-37, bitscore: 127.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTTVESDEATRLRNKVVDELRADGNISSSEIEAVMRKVPRHEF
                     TPADTPLDKAYDTYAAVITKTDEHGVQLSSVSAPQIQAMMLEQAQVKPGMRVLEIGSGG
                     LNAAYLAELVGDDGEVVTVDIDPVVTDRARRLLDEHGYGRVHVVTADAAEPVPDLGEVD
                     VVMVTAGAWDISPAWTAQLKSGGRLVVPLRMRGLTRSVSFIQVKGEHGPYLESESAKIC
                     GFVPMQGSNAHREELLLVNGTPEIGLKFDDGLPADPHRLDNAVTFPRHELWTGVSVRIQ
                     ELIDTLQMAMAISLPGFCTMAVDENSDTGLVDPVNKRFALAAVEDDTFAYLVTRRTEDN
                     KHLEYGVHALGPHAEQFADKIAGVLRDWEANRRGGPSPVIRAYPASTPDEQIPGDRVID
                     KVHSRISLSWPSA"
     gene            complement(13511..14176)
                     /locus_tag="B590_RS07725"
                     /old_locus_tag="B590_07845"
     CDS             complement(13511..14176)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014143560.1"
                     /locus_tag="B590_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07845"
                     /product="hypothetical protein"
                     /protein_id="WP_023416958.1"
                     /transl_table=11
                     /translation="MKRTSAAPRLVPYITQREGEYGGLESELTLSMNAFGAVRLAYQDE
                     TPADRGPRGELWARCSQSLNAAGKPTGKPQWRMVNPARQREAMEQLRCQVSFCPAETDQ
                     GYIFLAGNSEGASHRAGEPVRTAQPPVCLKHLRPAIELCPHLRKGHIAFRARATSPWGV
                     IGTRYRLTATGLEPLPADDDDAPVAYGHPQSGWFLASQLISELRDYEVVNLDDLVPAA"
     gene            complement(14173..14368)
                     /locus_tag="B590_RS07730"
                     /pseudo=""
     CDS             complement(14173..14368)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746445.1"
                     /locus_tag="B590_RS07730"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF5999 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MCAHNPPCPTAEAPDREAARPLAHRPEQEPAVQRSAPLRGHR"
     gene            complement(14413..14880)
                     /locus_tag="B590_RS07735"
                     /old_locus_tag="B590_07855"
     CDS             complement(14413..14880)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746446.1"
                     /locus_tag="B590_RS07735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07855"
                     /product="DUF6302 family protein"
                     /protein_id="WP_023416960.1"
                     /transl_table=11
                     /translation="MLTAAATLPRHSAAVSLRPAAEAYDYAHFRSRLAEPALLTDAVAV
                     RVFRAPLLAVPVGGPRRGGYMSFDLLTHATETHVLLAEHPGFPRLRVRSSPYRDTCHTV
                     EWGDAAPDWREDDAVFGRFYGYSEAAIAAFTRRHHQTPSSAVLEPCFPTAP"
     gene            complement(14874..15332)
                     /locus_tag="B590_RS07740"
                     /old_locus_tag="B590_07860"
     CDS             complement(14874..15332)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746447.1"
                     /locus_tag="B590_RS07740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07860"
                     /product="DUF6415 family natural product biosynthesis
                     protein"
                     /protein_id="WP_023416961.1"
                     /transl_table=11
                     /translation="MSLTVLVPENDVVPPPADEPRTPQWTPPLDAEGLRSVLDRIKNWR
                     PLDVEAVFDDLDTTIGNQPPPVATSDALVDRLRGHLKQLSDIAVADGRYPPTAEMVQLV
                     ERGRSLRDEPTPADYQRAVGLARRLAFVTSDLIEALIEARYIKGQLEC"
     gene            complement(15372..15845)
                     /locus_tag="B590_RS07745"
                     /old_locus_tag="B590_07865"
     CDS             complement(15372..15845)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024970.4"
                     /locus_tag="B590_RS07745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07865"
                     /product="ATP-binding protein"
                     /protein_id="WP_078493260.1"
                     /transl_table=11
                     /translation="MELLVDTREPDASVRATSRSVDGQLDMSFNVRAEDLGTVRDIVAA
                     HLCWWRIDTGTAHRMLTVVNELLTNVLQHTSAGADGCRMASLLLQKVPDGVTAIVRDQD
                     PCPPVYASPDLLAEEGRGLMLLRALADDTSVSVTPTGKDVWVFIGTPEPTEHF"
     misc_feature    complement(15938..15954)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 23.25"
                     /tool="antismash"
     gene            16021..17412
                     /locus_tag="B590_RS07750"
                     /old_locus_tag="B590_07870"
     CDS             16021..17412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031332.1"
                     /locus_tag="B590_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07870"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_023416963.1"
                     /transl_table=11
                     /translation="MKQLDPGASPQEWFGSELRRLRLEQGLSAKALGRLVQVSDDMILS
                     IEKGKYPSCRRDVVQRLDDALGTGGLLDRAWPMVFGDGDADKKRADADKAPPRRGEVRV
                     QAPAGRILGRDEPTLRPGSHEPVIRRSFLGIGGLAAIAPLSFTDAFAPAELSLPSHVNP
                     SHVDQVLAVANALSGMDNKLGGGGVVRDVAARAMQWSAGLLQAQFPEHLRTDLFAAVSR
                     LGIVVGASAFDAYHHDEATKTFRFAADCAEEAGDWHLRAKTYSFLARQAVWIGAPDDGL
                     TYAEKGLVRSDRLTATEQAMLHTARARAFGKMGNVRDTMAAVGAADEAFTRARPAEDPS
                     WMAYYDEAQHNGDTAHALFDLALLAGQDPGRAARRFDTAVKGHTDAYKRSRAISRTKLA
                     SLLMAKGDPRKAAALGHDALNEVGRLTSRRAADDLRQLGRFASKHRTVQEVSALRDRIA
                     ATVSA"
     misc_feature    16123..16125
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17409..18296
                     /locus_tag="B590_RS07755"
                     /old_locus_tag="B590_07875"
     CDS             17409..18296
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746450.1"
                     /locus_tag="B590_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07875"
                     /product="phosphotransferase enzyme family protein"
                     /protein_id="WP_037787063.1"
                     /sec_met_domain="APH (E-value: 2.2e-22, bitscore: 78.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSAAAPARHVLKQACSAVGLDSDGAEPLRLAENQIWRLPGRRV
                     IVRISRAGQSDAAAREVRVARWLAQENVPAVRLVDVEQPVESDGRPVTFWVELPPQQHG
                     SVEDVAELLARLHSLPTPAIDLGYLDPFVRVGERLHAATTIRDDDKQWLHSLHRDLVAA
                     WAERPTGLPDRAVHGDAWPGNIVRTADGVLMMDLERFSVGPPEWDLVSTAVRAKTTGAV
                     SAREYDRFCAVYGYDVTAWEGYPVLARARELRMVTYAAQHAANNAEWRSQAQYRIDCLR
                     GRSGPRPWSWTGIL"
     gene            18688..18954
                     /locus_tag="B590_RS07760"
                     /old_locus_tag="B590_07880"
     CDS             18688..18954
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024139.4"
                     /locus_tag="B590_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07880"
                     /product="AlpA family transcriptional regulator"
                     /protein_id="WP_023416965.1"
                     /transl_table=11
                     /translation="MSEPRAASQTAFLTLPRAAEYLGISPNTLYVWRHRRQGPPSFRMG
                     RRVMYRITALDEWVRDQERADSRSNRALDPLNRKPQQRSKAVK"
     gene            19075..20511
                     /locus_tag="B590_RS07765"
                     /old_locus_tag="B590_07885"
     CDS             19075..20511
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1077: phage integrase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349993.1"
                     /locus_tag="B590_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07885"
                     /product="site-specific integrase"
                     /protein_id="WP_023416966.1"
                     /transl_table=11
                     /translation="MAGYIEDRWLKKRPDKLTGKRERTAIYGSGKRYRVKGIPGIQDRS
                     FHTSEDAKRWLASAKTDSSRGEFVDPRKGEILLADYIAEYWWAGRSDEPSTADPMRSRI
                     WNHIIPLVGDCALREIDAAALRTFKAGLLTRVEESTAEVIWGHLCSILGSAVDDQRLLR
                     NPMKTKNSVKPPRAIDSKAKAWSREVVDAVRAGLQDRYQIAVDLGIGLGLRQGEAFGLA
                     EEDFDFAAGVVHIRRQLRWDIKGRPYFSLPKGRKTREVPLPANLVLRARDHFRRFPSTS
                     STLPWRNPEAPTTALEERQRKPITVDLILTSSHGNRIYYRTWNDRSWKRALAAAGLIKP
                     VGEKVRHDGNRVRRVPCYAAPREDMFHVLRHTYASVQLEAGESIVSLSKWLGHSTPKVT
                     LDHYAHFMPGAGQRGLAAMDAWLQDPSRPKVPEKSLPVPSIPRLPTNMQVKGMVRQGDD
                     MSVKYKETARGGLAVNIIEC"
     gene            complement(20585..21370)
                     /locus_tag="B590_RS07770"
                     /old_locus_tag="B590_07890"
     CDS             complement(20585..21370)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642092.1"
                     /locus_tag="B590_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B590_07890"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_037970259.1"
                     /transl_table=11
                     /translation="MRDGQRIAHNARVWNYWLGGKDHYAADAEVGEQVAGFHPGIRDVA
                     RADRAFLGRAVTYLVREAGVAQFLDVGTGLPTVDNTHEVAQRIDPGARVVYVDNDPIVL
                     THARALLAGTPEGATSYLDADAHDPAAILAGAARTLDLTRPVAVMLLGILNFVSETTEA
                     RRIVRHLVDALPSGSHLALTHPTLELGGTANAEAMAFWNANAKPPITARSAADLTGLLD
                     GLELLEPGIVSCSRWRATPGPDGALPEEVPQYGLVARKP"
ORIGIN
        1 atgatgttcc ggcgggactc ggacggacgg gatgtcgagt tgtcgagttc gacggtggcg
       61 ctggaggtgg agctgcagcg gcgggtcgag gccggcctgg agcagatgct gggcgtccgt
      121 ttcctggcct cggagtatcc gaccgggcct tggcaccggg ggcggatcga caccctggga
      181 ctcgatgaga acggcagccc ggtggtgatc gagttcaaga agggctcgga cagcggggtg
      241 atgtcccagg ctgtctccta cctgtcctgg ctggagtcgg cgcaccacga gttcgaggcg
      301 ctcgtgcgga aggtgctggg ggcggaggcc gccgagtccg tcgactggcg tcgtccgcgg
      361 atgatctgca tcgcggcggg cttctcgcac cacgaccggg tggcggtgca gaggttgccc
      421 gagcggatcg acctggtgcg ctaccggatc ttcgacggtg gcctgctggg gctgctgctc
      481 gtggactccg cgtccggctt cccgagtgct gcctcgtttc gccggggtcg ggagcgggcg
      541 cccgtggtgg acagcgtgcc gacggcttcg gtggtctctc cgcctgcggg tggaggggcg
      601 gtgccggagt gcctgcggga cctgtacgcg gagttggacg aggcgctcac ggcgtggggc
      661 gaggtggagg tggcgtccct gcggcattac atcgcctacc ggcggttggt gaacgtggcg
      721 tcggtgatct tccgtccgaa gcacgaggcg atcctggtgt acctcagact cgaccccgac
      781 acggtcgagc tagaggaggg cttcacccgg gacatgcgcg gtatcggaca cctcgggacc
      841 ggcgacctgg aggtccgtat cgtctcggca gccgacttgg agaaggcagc gccgctgatc
      901 cggcgggcgt tcgaggcggc ctgacgcaac aggaggggcg gctggtgcat cggttagttg
      961 atgctccagc cgcccctctg gcgtctgtgg gccgccggcc ctggcctctc ttcgctctca
     1021 cgctcatgcc tccggtccgg ccagctcgaa gtcgtccttc gtcagttcgg cccgcagccg
     1081 ctcctcggcg acgtcggcgt agtgcgcgga cagctcgacg ccgacgaagc ggcgtccctc
     1141 gcgcagggcc gcgaccccgg tggagccgct gccggtgaac gggtcgagga cggtgccgcc
     1201 ctcggggcag acctggacga gctgctgcat gacctcgacc ggcttctggg tgatgtgaac
     1261 ccggcccttg cggggctggg aggcgatgta gtgccccggc aggtagagat cgcgggtgtt
     1321 gtcgagggag cccttgacgc cccagatgat gaactccgag tcctgcttgg gcccgccctt
     1381 gcggggccgg ctggacggct tgatccacgg aatcgtgccg ctccaggtcc accccgccat
     1441 ctgcagggcg tcggaggtgg tcggctcctg gcgccagtcg gtgaagacca tcgcgaccgc
     1501 gtgctcggtc gaggcccggt acgcctcggt gagcagttcg gtcagccagg agcggtagga
     1561 gcgctggtcg cggttctcgc ccgggaagtt ggcgaggtcg tgcgccgagt tgctcgtgac
     1621 gtacttggca cgtgcggtac ggccggtccg gtcggagctg gtgcggcccc cggagttgta
     1681 cggcggatcg gtgatcaccg cctggacgct ctcgtccggg agggacttca ggacggccag
     1741 ggcgtcgcct cggtgcagcg tgtagctcat ggggagggcc tctcttcggg cgcggcggag
     1801 tctggacctg ctccgggcag cgctcaacgg cgcgcatccg gtgcgaggtt gcagcggagg
     1861 ttaacggcga attccggccg cgcctaacga ggtggctccc tgcttcgggc ccctggatgg
     1921 cagtcgtttg gcgcggccgg aatcccggtc tactgtctcg ccgtgccacc gggaaggagc
     1981 gctgctccac ccccgttgag ctgtgctaat ccgtgctgtc tcgtccaatc gagcagcgtc
     2041 ggaggcatgt tgcccatctg cccgcgagcg ccgtgaggag gcccctgtgc actgcctgag
     2101 attacgagcg cggctggctg ccgcgcgtga cctgaaactg gcgtcctgga gctaccaact
     2161 cctctgaccc gggcccgccg agaggcggat gcacatcggc gcggcgccga cggctttgca
     2221 cgagaagtcg gcaccgcgtc tccttcgaac accgaggagc cgctgcgatg cagcatgccc
     2281 tgacacaccc gccccgaccc acctccgtcg ccccgtccgc accgccgtcg cgctgaacgg
     2341 cggcggccgt gaagaagacg acgggagccc tcgtcggtct gtgcgccacc ggaccgctcc
     2401 tgctggcact gccgatcctt ggcatcgggg ccgggaccgc ctcggcttcg tgctcgaccg
     2461 acggtgcaca gggtgtggac gcctccgccg tcgccaagca ggtgaaggcc atcctggacg
     2521 gcggcgacaa gggctcggtc tccgtgccgg ggctggacgc gcctgccgac caggtgccca
     2581 acgccaagac gatccaggcc acgggcgtcg cgatgaacat ccccgcccga gggcaggtcg
     2641 tcgccctggc gaccgctctg caggagagcg gcctgcggaa cctgacctac ggcgaccgcg
     2701 attcgttggg tctcttccag cagcggccgt cgatgggctg gggtacggcc agccagatcc
     2761 tggacccggt gcacgcctcg acgaagttct acgaggggct caagaaggtc tccggctggc
     2821 agtccctctc tgtcacccag gccgcgcagg cggtacagaa gtcgggcttc ccggaggcgt
     2881 acgccaagtg ggagccgctg gccaccgccc tgcagaaggc catcgagccc ctgctgcaga
     2941 acgccggcgg cgcatcgccg agcccgtcgc cgtccggctc tgccgacacc ggcagcccct
     3001 ctcccgattc cgcggggggt tgttcggcgg acggcgatgg gacggacttc ggcaccatcc
     3061 cggcgggcgc cctgccggac gagtacaaga ttcccgcctc cgcgcccccg aaagtgcaga
     3121 cggcgatccg gtgggcgctc ggccagctcg gtaccccgta tcagtggggc ggcacgtgca
     3181 ccgactccca cggcaagaac ccgatgggcc gctgcgactg ctcctccctg atgcagggcg
     3241 cgtacaaggc ggccggggtc accctgacgc ggaccacgta cacgcaggtc aaggacggca
     3301 aggccgtctc ggtcgatgcc ctcaagccgg gtgacctcct cttcaccgag gggacggccg
     3361 ccgtaccgga acacgtcggg atggcgatcg gacagggcct gatcgtccac gccccacaca
     3421 ccggcgacgt cgtccggatc accaccgtcg cgtcctggaa atcgcggatt ctcgcggccc
     3481 gccgagtcgt ctgaccggcg ctcctccccc tcctcacctc cccctcgcac cgctggttcg
     3541 ccccgccggg ctttggcgtg cgctcattcg gactggagtt cccatgtatc tcgctgacca
     3601 ggtcatacag ctcgcctacg accccggaat caagcccaac gagggcgggc tccctggcct
     3661 caacgtcctc aagcaggtga tgggctcgat ctgaaccgtt ccgggttcgg tagagactcg
     3721 attccgtgaa aggatcgagt catggcacgc ccttcctcct atcccgttga gctgcgcaaa
     3781 cgagcggtcc gcatggtcgc cgaggtccgc ggcgactacc cgaacgagtc ggccgccgtg
     3841 agggcggtcg cccagaaact cgggatcggt tcggccgaga ccctgcggaa ctgggtgaag
     3901 cgggacgagg tcgactccgg gaagcggccg gggacgacca cggaggagtc cgcgcagatc
     3961 aaggcgatga agaaagagat cgccgagctg aagcgggcga acgacatcct gaaggctgcg
     4021 gcgagtttct tcgcggccga gctcgaccgg ccacacacac gctcgtagcg ttcatcgacg
     4081 agcaccgggc ccgcttcggc ggtgtcgagc cgatctgccg cgtgctcacc gagcacgact
     4141 gcaagatcgc cccctccacg tattacgccc accacaaacg actccaggac ccgtcggccc
     4201 gcaccgtccg cgatgctgaa ctgaagccgc tcatcaggga gatcttcgag gtcaactacc
     4261 gtgtctacgg ggccaggaag gtttggcgtg agctgcaccg tcaaggccac gtcgtggccc
     4321 ggtgcacggt cgaacgcctg atgcgtgagc tcggcgtcac cggtgccgtc cgtgggaaaa
     4381 agatcatcac tacgatcccg gacagctccg tcgagcgggc gccggacctc ctggaccgca
     4441 acttcgtcgc gccggccccg aaccgctgct gggttgccga cttcacccac atcagcacct
     4501 ggtccggagt ggtctacgtc gccttcgtcg tggacacctt ctcccgccgg atcgtcggct
     4561 ggtccgccgc cacgtcgaag gagacacggc tcgtcctgga cgccctggac atggctctgt
     4621 ggcaacgcga ccgagacgaa cagccgtacc aggaaggtga gttgatacat cattccgatg
     4681 ccgggtcgca atatacgagt ttccggctcg ccgagcacct ggacgccgcc ggcatcgcgg
     4741 cctcgatcgg ctcggtcggc gacgcctacg acaacgccct catggagtcc acgatcggcc
     4801 tgttcaaaac cgagctgatc aagcccggac ggccctggag aaccctttcc caggtcgaac
     4861 tcgccaccgc cgagtggatc gactggtact gccaccgccg actccacggt gaaatagggc
     4921 acataccacc cgtcgaatac gagaccaact actacctcac cagcacgaaa ccccaggtca
     4981 caaccacaac ctgaagtctc taccgaaccc ggaacggttc aatcaacctc ttcggactca
     5041 ttgccgtagt cggagccctt gccgtcagtg cgggcgtgtg ggcctggggt caccactccg
     5101 gtggtcacca ggccgaggcg aacgggaaga agggcgtgct ggtaagcgcg ggcgcggccc
     5161 ttcttctcgg tgcggccaac ggggtagtgg cgttcttctc gacgctcggg acgcaggtcc
     5221 actgatggct cagcactcca cccaccccgg cggcgcatct cgcgtgcgcc gccgggcgct
     5281 gctcggcact gccgtcctgg cggtgctcgt cgccctcgcc ggcctggccg cctacctcac
     5341 ccgcgagggc cgaagcccct ccgatactgc ttccccaccg ccgagttcgc ccaccgcgtc
     5401 ctcgtcgccc gcggcaccgt ccgggccgca cacccggccc cgcgctctgc ccgttccgcc
     5461 gaaaacccac gacccgatca cgtacgggaa ggccgccgcc gcagcgctgt ggtcgtacga
     5521 cacccgcgcg tactcgcagg ccgagctgcg caaggcgctg cgcggctggc tgaccacgga
     5581 gtcgaagtac gccgacccgg cctccgtcga ccaggcggtc ccctcggccg tgctgtggaa
     5641 ggagatggcg gccaacaagc aggtcgccac cgccaagatc aacgaggggc acttcccgca
     5701 caccttcacc caggccctcc aggacgaccc cggggcgatc acccaggcgt acgtctacgc
     5761 cgtcacggtc tccggcaagc agtcgattcg ctggaagggc tcgaccgccg gcggcgcgga
     5821 gagccggtcc accaccctcg cggtccagtg ccggcccaac cacccctgcg ccctggtcgg
     5881 cgtcatgccg tccgtcgcgc cctgaccctc gccccagaac ggaggtacga cccatgggag
     5941 tctgcgactt cccgctgatg gacaaggtgt gcggcgctgt cgacttcgcc accaaccccg
     6001 ccggcaccgt caccgacggc ctcggcgcgt ggatcgcgaa gtcggcgggc gagctggcgt
     6061 ccagcgcggc cgacctggcc gccaaggccg tcaacaagac gacggccatc gacctcaacg
     6121 ccggatggtt ccgcgacaac tacgagctgc tgctgcccat cggcctcgcc ctgaccgtcg
     6181 gcatcttctg catccagctc atgaccgcgg cctggcgccg agacgaacgc gccctcgcca
     6241 aggcggcgtt cggcaccatg accggagtcc tcttcagctt ctccgccatc gccttcacga
     6301 ccgtcgccat caccgtggtc gacgcgctgt ccgacggcct cttcaaagcc gccaacacct
     6361 cgatcgacga cgcgatccgt cgtgtgatca aagtcgatca gatgggggcc atgtacggcc
     6421 tcggctgggg tgtacccgcg ctggtggcct tcgggtgcgc gatcggtgcc ttcctctact
     6481 ggggcgtgat ggtggcccgc aaggtcggcg tcctgatcat ggtcgcgctc gcggtgttcg
     6541 ccggggcggg cggcggctgg gaagtcgcca aacggtggcg gcgcggctgg atcgaggcca
     6601 ccggcaccct gatcgtctcc aagctgttga tgaccgtggt cttcctgatc ggcgtctccg
     6661 ccatgggcaa gaccgacgcc agcgacggaa tggcggccct ttccgacgcg atggccggca
     6721 tcgtcgtgat ggtcttggtg ttgctctgcc cctacgcgac gtacaagttc gtgcactggg
     6781 ccagcgacgg tggtggccac gacgacatgc accgtaccgg cgtcgctggc atggcagtcg
     6841 cttccggagc cgcgaagacc gcgggcagtc tcgcgatgcg ggccagcacc ggcacccccg
     6901 ctccgcaggg gccgaaccag gtccccggtg cagggaccga tggcgtcgcc tccggcatca
     6961 acccctccgg cggcaacctc agcaaggagg gcatcgacgc cgggccgccc aagcagcaga
     7021 cccgcttccg gtacggcgaa gacccggacg cgagcggcga caagggccgg gctctgatcc
     7081 agcgccccgg gatcccgccg ctgatcacac gtcctggcga ggacgaaccg gaagggtccg
     7141 agtcgactgc ccagggcgtc gcgggcggct ccggtcacct cgcagccgca tcggctccgg
     7201 gcggcgacat gacctccatg ccgccagccg accccggacc ttcggcctcg ggcactccgg
     7261 cgtccgcgtc cggaccgtcg gccaccggct ccgcgacgcc gacgaactgg gtgtatccca
     7321 cccagccgcc gtcgggttcc tgacccacat ccccgggggc gggccgcatt ccacggcccg
     7381 cccccgcccc ccaccagcag gaaggtttcg ccatgacgtc cagaagagcg ccgcgcgccc
     7441 cgtcctccgc ccgctcccac cgtctggaac caccatgtcc ggcaagcacc agtcctccac
     7501 gcccaccgtg aagttcccgc accgcagcag gcgcggcgtc ctgctgggcc tgtccgtccc
     7561 gcagttggtc gtcgccgggc tcaccggcct tctccttctc gccgtgatcc tcgcccgcgg
     7621 tgtggtcggc gccctccagt tcataccgct gtgggccgtg atcgccctgc tcgtcttcgt
     7681 ccgccaccga ggccgtgctc tggcggactg ggccccgatc gtcgtccggt acgcgctgcg
     7741 ccggatgcga ggccagctcg tctggctcac ccggccctcc cgccggccga cccgcgaggg
     7801 cctgctccac cttcccggca ccgctgccag cctgcgcgtg accactgctc ccgacggcaa
     7861 gtacggcgcc gtccacaacc cgcacaccgg gacgctgacc gtggtggtca aggtctcctc
     7921 ccgcgcctac gccctgctcg accccggcac ccagcaggcc aacgtcggcg gctggggacg
     7981 cgcgctggca gctctcgccc gtaccggaca gatcgcccgc atccaggtga tcgagcgcac
     8041 catccccgac tccggcgacg cgctgcgccg ctattgggaa gagcacggcc gccccgacac
     8101 cccgatggcc ggcgcgatct acaacgagct gatccagagc gccggtcccg cagccgcccc
     8161 gcacgaggcg tacgtcgcgg tgtccttgga caccaaggcg gcccgtcggc tgatcaacca
     8221 ggccggtggt ggtctgaccg gtgccttcag tgtcctcgcc cagctcacct ccacgttcga
     8281 ccaggcggcg cgaaccgccg gtctcacccc gacgggctgg ctcaccgccc gcgagatcgc
     8341 cgccgtggtg cgtacctcct acgacccgaa ggcgctggcg acactcgacc gctggtccac
     8401 ggccggtcgc cccgaggccg agcccgccgc cgccggcccc gtcgtggtcg tcgaaagggc
     8461 ggaccacatc gccaccgact ccgccgtgca cgccacctac tgggtggaga actggccgcg
     8521 caccgagacc agcgccggct tcctgcacca gctcctgttc accggcggcg tccggcgcac
     8581 tctatcgctc tcctacgagc cgaagaacct cgacgccgcc ctgcgcgacg tgcagcgcaa
     8641 gaagtccagc gtgatcgccg acgccgccga acgcgcccgg cgcggccagg tcgactccga
     8701 ggcggactcg atcgagtacc aggacatcaa gtcccgcgaa cgccagctca tcgccgggca
     8761 cgccgacgtc gccctgaccg gtctgctgac cgtctcggcc gacaccgagg acgacctgcg
     8821 caccgcctgc gccgtcgtgg agaccgccgc tgtcggcgcc cagctcgatc tgaggcccct
     8881 gacctggcag caggccgagg cattcaccgc cgccgccctg ccgctcgcgc tcgccgcctg
     8941 agcatccctt cccttcgaaa gagcaccctc atgtcccgca ccgccagccc gaccgcgcag
     9001 gacttcgtgc ccttcgccac cgccgcgctc gacttccacc gggcactcaa catcccgggc
     9061 ggcccgctgg tcaccacccg ggccgagctg gacaccctgc acgcccacct catctcgctg
     9121 tacgggctgc tcgacgccca cgccagtcgc accgggcagc tcgtggcggt cgagggcgac
     9181 cagctccgca ccgcccgcac tcgcatctgg caggccgccg agcacctcca cgccgcctac
     9241 cacgcggcac cccggccgga ctccggcgag atccccgcac cggaggcgtg ccaggccggc
     9301 cttccagagg gcgcaccgga actgaccatc tgccagcgcc accagcgcac cgctcatctc
     9361 gtgcggcggc gcaccacccc ggccgacctg cacgccccgt tcaccggcct cgtccgccgc
     9421 tgacccaccc ctcatctgga gaaacgctca tgccccgtac ccgcgccagc gcctcccctc
     9481 tgttcgtgcc ccgtaagacg acacgcgccg aacagcgggc tgcccgagcc ggtttcaccg
     9541 aggcccgccg ccaggcacgc ctcgccggaa gcccgcccaa gcaccgcgcg gagcagaccc
     9601 tcgacccgga tctgcggccc acctatccgc tctccggtcg ccccggtccg gcgtccgccc
     9661 gcggcggcaa gctcgccctt cccgcccacc ggatgaccac cgcgacagcc agcggcgcgt
     9721 acccgttcgt ggccgagggc ggcctgggcg ccgaaggggt gttcatcggc cgcgatgtgc
     9781 acgcggaggc ggctttctgc ttcgacccgt tctcgctcta caacagcggc agggtggagg
     9841 gcttcacgaa ccccaacgcg gtcctggccg ggatcatcgg catggggaag tcggcgctgg
     9901 cgaagtcgat cgccacccgg tcgatcgccc acggctaccg gatctacatc ccctgcgacc
     9961 ccaaggggga gtggaccgct gtctcccagg ccctcggcgg ctacagcatc gccctgggcc
    10021 cggggctccc cggccggttg aaccggtcgg cgatgacggc gatgtcggcg agcgggatcg
    10081 tcgtctcgtc tgtcttctgg tggccggaca gctcgatgac gtggggcagc agccgcggcg
    10141 tgcgggtgac gttctcgttg cggtggcggc gcggtgggaa gacgagctgc gccgtgaggc
    10201 tgtgcggcgc tccgtggtac gtggcggcga gcgcgtcctg atgctcgggc ggcagggcgt
    10261 gggcgaaccg gccggccatg ctgctgccgg gccgggggac tgcggtgagg aggatgtcga
    10321 aggcgccgct ggagagtgcc cgggtgctgg aggagtgcac ttcgaaggcg acctccaccc
    10381 gggggacgaa cagccgctcg tccttcccgg cggccttctc cagggcatcg accatgtcgt
    10441 ccgtcagccg cagttcacgg ccgccgccga ggaggacctg ctgcatcatc gcgagcagca
    10501 gttcgtcgcg gtcggtgcgc accttcaggg cggcgccgcg ttcggagccg acgtatccgg
    10561 cgggcaggcc caggccgctg tcggcgacca ggtccatcac cggcaccagg gcgccgacgc
    10621 cgtaccgggc ccggaagcgg cggtggtagt cgcgccagtg ctggtagccg tagggctgcg
    10681 gggtggtgcg gtagagcgcc gagacggctg cttgcgcttc cgcgatcacg gactgcggga
    10741 gcgtggtctc gcagtcgagg gcggtgtcaa tgagcagcgg tgtcggcgtg acgggggtga
    10801 gggcacgcat ccgcgtggcg acggtgctca cgctggtgtc ggagagggtc ggctggtggg
    10861 cggacagctc gtcgcgcagg gcgtacagct cgtggaccag gtcccgcact tcggggatgc
    10921 tgtccgcttg gagccggtcc agttcgtggc acaggtgctg gaaggcgtcc acggtggtca
    10981 tgggcgccca cagactggtg atgaggaact gctgctcgac caggctggcg agaagtgcgt
    11041 cgatcttctc cggagcggcc tgcggaaagc gggcgcgcag gtcgccgtgg agaccgctgt
    11101 aggggacggg ggtgcaggcc gcttccatgg ctgcggccac cggccgggcg ttgcgcacgg
    11161 atatctcgac cggggctagg aggacggcgt ggccgtcgga gggcggaccc ggcgccacaa
    11221 gccggtcacc gcgagcgcgg gcggcgttgt tggcgacgac cggtaaccgc ttcagcaacg
    11281 ccgtggtgcg ctggagccgg aggaccatgt cggtgaccca ttcggcgtcc ggccggatca
    11341 ccgcacggtg cttgtcgcgc caccgtgcac tcgcccgggg cccgacggag accggggcga
    11401 tgccggcgaa caggccgagc ggggtcggcc ggtgctgcca ccgaaggagg taagagaccg
    11461 tcgacagtgc ggtgcggcgc acctgacggg gctcggtctg ccggccccgg acgacggcct
    11521 caatggcgtc ggacagaacg ggggtggcca actccagcgc gcggcggaag tcctcgcgct
    11581 gccagatgcg gttcagccat ccgcgggtga cggccacgtt gtccaggtcg agggtacgag
    11641 gaatgtctgc cggcccgggg ctggtggtgg cgcgcagcat cgcaacgcct tgccacaggt
    11701 atccggcggc tgctcgggaa gccatgaagc ccttccatga ggcggcgcgg gaggagaggg
    11761 ggcctgtggc cgggcgaagc gcttcgcccg gccacaggtg aggaggtcgg cctggatcag
    11821 gccgggtcct cggtgaagga accgcaggcg gaggcaccgg tcgcgcaggt ggtgccgcag
    11881 ccgtcgcccg tcgagcacat gaggtggccg tacgagtgct cggcgatgac gaccttcacg
    11941 tccaggggcg cgaagtcgtc ctccaggtcc gccgcaggcg caaccggggg cggggcgaga
    12001 gtggcgctcg tcatgttggt gcccttcttc tcgttggggt ggtgcgggac gacctgactc
    12061 ccggcgttac gccgagggcc aggagagcga gatccggctg tgcaccttgt cgatgacccg
    12121 gtcgcccggg atctgctcat cgggggtgct ggccggatag gcccggatga ccggactggg
    12181 gccgccacgc cggttggcct cccagtcgcg gagcacaccg gcgatcttgt cggcgaactg
    12241 ctccgcgtgc gggccgaggg cgtgcacgcc gtactccaga tgcttgttgt cctcggtgcg
    12301 gcgggtgacg aggtaggcga aggtgtcgtc ctcgacggcc gcgagcgcga accgcttgtt
    12361 cacggggtcg accaggcccg tgtccgagtt ctcatcgacg gccatggtgc agaagcccgg
    12421 caggctgatc gccatcgcca tctggagggt gtcgatgagt tcctggatgc ggacggagac
    12481 gccggtccac agctcgtggc gcgggaacgt gacggcgttg tcgagccggt gcgggtcggc
    12541 cgggaggccg tcatcgaact tgaggccgat ctccggggtg ccgttgacga ggaggagttc
    12601 ttcccggtgg gcgttcgagc cctgcatcgg gacgaagcca cagatcttcg ccgactcgct
    12661 ctccaggtag gggccgtgct cgcccttgac ctggatgaag gagaccgacc gggtcaggcc
    12721 gcgcatccgc agcggcacca cgagccggcc gccggacttg agctgcgcgg tccaggccgg
    12781 ggagatgtcc caggcgccgg cggtcaccat cacgacgtcg acctcgccga ggtccgggac
    12841 gggctcggca gcgtcggcgg tgacgacgtg cacccggccg tagccgtgct cgtccaggag
    12901 ccggcgcgcg cggtcggtga cgacggggtc gatgtccacg gtgacgactt caccgtcgtc
    12961 gccgacgagc tcggcgaggt aggccgcgtt cagcccgccc gagccgatct ccaggacccg
    13021 catcccgggc ttcacctggg cctgctccag catcatggcc tggatctgcg gcgcggagac
    13081 ggagctgagc tgcaccccgt gttcgtccgt cttggtgatc acggcggcgt aggtgtcgta
    13141 cgccttgtcc agcggcgtgt cggcgggggt gaactcgtgc cggggcacct tgcgcatcac
    13201 cgcttcgatc tccgaggagg agatgttgcc gtccgcgcgc agctcgtcca ccaccttgtt
    13261 ccgcaggcgg gtcgcctcgt cggactcgac ggtcgtgttc gtcatggctt ccttcggtcg
    13321 ttcgtgttca gggagggggt aggtcggcac ggtgtgccgg cgggccggga ggctatcggc
    13381 gaacgctctc cgttcttgcc ggacctccga aggtcggcgg tttcgtgccg gacggcgcgc
    13441 gaagggctcg gcgccggtgg tgagccgccc aggagccccg tccgtatcac tcagggcccc
    13501 gggcggccgt ctaggcggcg ggtacaagat cgtccagatt gacgacctcg tagtcccgca
    13561 gttcgcttat gagttggctc gccaggaacc agcccgactg ggggtgcccg tacgccacgg
    13621 gcgcgtcatc gtcgtcggcg ggaaggggtt ccaggccggt ggcggtgagg cggtaccggg
    13681 tgccgatgac gccccagggg gacgtcgccc gcgcgcggaa ggcgatgtgc cccttccgta
    13741 gatgcgggca cagctctatg gccggccgca ggtgcttcag gcacaccggc ggctgggccg
    13801 tcctcaccgg ctcaccggcg cggtgggaag cgccctccga attcccggcg aggaagatgt
    13861 agccctggtc ggtctcggcc gggcagaagc tgacctggca ccgaagctgc tccatcgcct
    13921 cccgctgccg ggcggggttg accatgcgcc actgcggctt gcccgtcggc ttcccagccg
    13981 cgttcagcga ctgggagcac cgggcccaca gctcgccgcg gggcccgcgg tcagccgggg
    14041 tctcgtcctg gtaggcgaga cgcacggcgc cgaaagcgtt catgctcagc gtgagttccg
    14101 actccagccc gccgtactcg ccctctcgct gggtgatgta cgggacgagc cgaggcgccg
    14161 cgctggtccg cttcacgcgg ctgccctcgc cacgttgagg gcgcggtgcg gggcgatgac
    14221 ctggccgtcc ggcagtagct caccggtgtc ctcgaagagg agcactccgt tgcacagcag
    14281 gctcctgctc aggccgatgc gcgaggggcc gcgcggcctc cctgtcggga gcctcagccg
    14341 tggggcacgg cggattgtgc gcacacatga tgctcgtcct ctcgggtggg aagtcgggcc
    14401 ctcttcggcc agctacggtg ccgtggggaa acacggttcg agcacggccg aagagggagt
    14461 ctggtggtgc cgccgagtga aggcggctat cgcggcttcg ctgtagccgt agaagcgtcc
    14521 gaagaccgcg tcgtcctccc gccaatcggg tgcggcgtcg ccccactcga cggtgtggca
    14581 ggtgtcgcgg tacggcgacg atcgaacgcg caggcgcggg aagccggggt gctccgcgag
    14641 gaggacgtgc gtctccgtcg cgtgggtcag caggtcgaag gacatgtatc caccgcggcg
    14701 cggcccgccg acgggaaccg cgaggagcgg cgcccggaag acacggactg ccacggcgtc
    14761 cgtgaggaga gcaggttcgg cgagacggct gcggaagtgc gcgtagtcgt acgcttccgc
    14821 agccggacga agggagacgg cagcggagtg gcgcggcagc gttgcggcgg cggtcagcat
    14881 tcgagctgcc ccttgatgta gcgagcttcg atcagcgctt cgatcaggtc ggacgtcacg
    14941 aaggccaggc ggcgagcgag accgacggct cgctggtagt cggccggcgt gggctcatcc
    15001 cggagggagc gacctcgctc aacgagttgg accatctccg cggtgggcgg gtaccgcccg
    15061 tccgcgacgg cgatgtcgct gagctgcttc aagtggccac ggaggcggtc gaccagggcg
    15121 tcgctcgtcg cgacgggcgg cggctgattg ccgatcgtcg tgtcaaggtc gtcaaagacc
    15181 gcctccacat cgagcggcct ccagttcttg atccgatcca ggacggacct caagccctct
    15241 gcatcgagtg ggggtgtcca ctgcggtgtg cggggctcgt cggctggcgg gggaaccacg
    15301 tcgttctccg gaaccagaac ggtgagggac atcgggtact cctggagagg gccaagtgcc
    15361 ggccgtgggg gctagaagtg ctcggtgggt tccggggtcc ctatgaagac ccacacgtcc
    15421 ttgcccgtcg gggtcacgga cacggacgtg tcgtcggcca gggcacgcag cagcatcagg
    15481 ccgcgcccct cttcggccag gaggtccgga gacgcgtaca caggcgggca ggggtcctgg
    15541 tcgcggacga tggcggtgac gccgtccggc accttctgga ggagcaggct ggccatacgg
    15601 catccgtcgg cgcccgcgga ggtgtgctgc aagacgttgg tgaggagttc gttgaccacg
    15661 gtcagcatgc ggtgcgcggt gccggtgtcg atgcgccacc agcacagatg cgccgcgacg
    15721 atgtcccgga cggttcccag gtcttcggcc cggacgttga agctcatgtc gagttggccg
    15781 tccacacttc tggacgtggc tcgaacagaa gcatccggct cgcgggtgtc gacgagtagt
    15841 tccatcgctg gttcctccgt tctgccataa ccccttcagc aggggtgggt tgcggtgtgt
    15901 actggtctgg aaccgatcag caaccattta ggcagagcgc accgagaacg tgcagagcct
    15961 gatgccgaga ggtgaagagt tcggcatcga cgacttcggg gacaggacat gccgcagcca
    16021 atgaagcagc tcgatccggg ggcgtccccc caggagtggt tcggcagcga gctgcgcaga
    16081 ctgcgcctgg agcaggggct gtctgccaag gcgcttggtc ggttagtgca ggtcagcgac
    16141 gacatgatct tgtcaatcga gaagggcaag tacccgagct gtcgtcgcga cgtggtgcag
    16201 cggctcgatg acgccctcgg cacgggtggg ctccttgacc gggcgtggcc gatggtattc
    16261 ggcgacggcg atgccgataa aaagcgggct gatgccgata aggctccccc gcgccggggg
    16321 gaggtgcgcg ttcaggcgcc cgcaggccgc atcctgggca gagacgaacc gactcttcgc
    16381 cctgggagcc atgagcccgt gattcgacgc tcgttcctcg gaatcggcgg cctcgccgcc
    16441 atagcccctc tcagcttcac cgatgccttc gcgcccgccg agctgtctct cccgtcccac
    16501 gtcaacccga gccacgtcga ccaggtcttg gccgtggcca acgccctcag cggcatggac
    16561 aacaagctgg gcggcggggg cgtggtacgt gacgtggccg cccgagcgat gcagtggtcg
    16621 gccggcctgc tgcaagcgca gttccccgag cacctacgaa ccgacctgtt cgccgccgta
    16681 tcgcgcctcg gcatcgtggt cggcgcctct gccttcgacg cctaccacca cgacgaagcc
    16741 accaagacgt tccgattcgc agcggattgc gccgaggagg ccggcgactg gcatctgcgg
    16801 gccaagacgt actcgttcct cgcacggcaa gccgtatgga tcggagcccc cgatgacggc
    16861 ctcacctacg ccgagaaggg gctcgtgcgc tccgaccgct tgacggcgac agagcaggcg
    16921 atgcttcaca cggcgcgggc cagggccttc gggaagatgg ggaacgtccg cgacaccatg
    16981 gcggccgtcg gcgccgcgga cgaggcattc acccgggccc ggcccgccga ggacccgtcg
    17041 tggatggcct actacgacga ggcgcagcac aacggggaca cggctcacgc tctgttcgat
    17101 ctcgcgctcc tcgccggaca ggacccgggc cgggccgcgc gccgattcga cacagcggtg
    17161 aagggacaca cagacgccta caaacggtcc cgggcgatct cgcggaccaa gctggcctct
    17221 ctgctcatgg ccaagggcga cccgcgcaag gcggcggcgc tcggccacga cgccctcaac
    17281 gaggtaggcc ggctcacctc ccggcgagct gccgacgacc tgcggcagct cggccgcttc
    17341 gcctcgaagc atcggaccgt ccaggaggtt tcggcgctgc gagatcggat cgccgctacg
    17401 gtttcggcat gacttcttcg gcagccgcac cggcgcgtca tgtcctgaag caagcatgct
    17461 ccgcagtcgg attggactcc gacggagcgg aacctcttcg cctggccgag aaccagatat
    17521 ggcggctgcc cggcaggcgg gtgatcgtac ggatatcacg ggcgggccag agcgacgcgg
    17581 cggctcgtga ggtccgagtc gcgcgttggc ttgcccagga gaacgtcccg gctgttcggc
    17641 tggtcgacgt ggagcagccg gtcgagtcag acggcagacc cgtgaccttc tgggtggaac
    17701 tgccgccgca gcagcacggc tcggttgagg atgtcgctga actcctcgcg aggctccact
    17761 ccctgcccac gccagcaatc gacctggggt acctcgaccc cttcgtccgg gtcggcgaac
    17821 ggctgcacgc ggccaccacg atccgcgacg acgacaagca gtggctgcac tcccttcacc
    17881 gcgacctcgt agcggcttgg gccgagcggc cgaccggtct ccccgatcgg gctgtgcacg
    17941 gtgatgcctg gcccggcaac atcgtccgca cggctgatgg ggtcctgatg atggacctgg
    18001 agcgcttttc tgtcgggccc ccggagtggg atctcgtgtc cactgccgtg cgcgcgaaga
    18061 ccacgggcgc cgtcagcgca cgcgagtacg accgcttctg cgcggtgtac gggtacgacg
    18121 tgacggcgtg ggagggctat cccgtcctcg cgcgcgcccg tgagctgcgc atggtgacgt
    18181 acgcagcgca gcacgcagcc aacaacgcgg agtggaggag ccaggcgcag tatcggatcg
    18241 actgtcttcg tggtcgatcc ggcccgcggc cgtggtcgtg gacgggaatc ctctgagacg
    18301 cgtgtctcca ccaccgtccg ggccggatcg aacaccccgg ccgctcccca ccccacggtc
    18361 aggacgacgc tccaccacgg accacaggcg cagtactcgc ccatcatctt gcccaccgct
    18421 gagtaactcg ggctgtagcg cgtgatcaga gggctctgag ctgatcgtgg tgcgcgtcgc
    18481 cgctggctgt cggcgttgca ggaccaactg attcagcggg ccgcaccccg tgaacctccc
    18541 gcctctcaga tccctgttcg aggtatcagg ccgatcgacg gcgctgcgga cgtcggctga
    18601 tcccttctat cccaggaatc cggttcgtcc aactcgctct ttctccggaa tctcgtcctg
    18661 tcatcgccac acgacaggag tcgacgcatg tcagagccgc gggcagcatc ccagaccgcc
    18721 ttcttgaccc tccccagggc tgccgaatac ctcggtatct cccccaacac gttgtacgtc
    18781 tggcgacacc gccgacaggg gcctcccagc ttccgcatgg gacggcgtgt gatgtaccgg
    18841 atcacggcgc tcgacgagtg ggtccgcgat caggagcgag cggactcccg ctccaaccgc
    18901 gcccttgacc cgctgaaccg gaagccgcaa cagcgctcga aggccgtgaa gtagcgcggt
    18961 ggctcacgcg tccggtctcc ccgagaagaa gtcctccgca cggggattgg atcgcgccgc
    19021 agatcgcgtt agcaccgacc agctcatgat cacgcaccac tggagggccc cgtcatggcg
    19081 ggttacatag aagaccgatg gctgaagaag cgccccgaca agctgaccgg gaagcgggag
    19141 cggaccgcga tctacggcag cgggaagcgc taccgggtga aggggattcc cggtatccag
    19201 gaccggtcgt tccacacgag cgaggacgcg aagcggtggc tcgccagcgc caagacggac
    19261 tccagccgtg gcgagttcgt cgatccccgc aagggggaga tccttctcgc cgactacatc
    19321 gccgagtact ggtgggcggg ccgctccgac gagccctcga cggcggatcc gatgcgcagc
    19381 cgcatctgga accacatcat tccgttggta ggcgactgcg ctctgcgtga gatcgacgct
    19441 gccgctctac ggactttcaa ggcggggctg cttacaaggg tcgaggagtc gacggcagag
    19501 gtgatctggg ggcacctgtg ctcgatcctc ggcagtgccg tcgatgacca gcggctgctc
    19561 cgcaacccga tgaagacgaa gaacagcgtc aagcccccac gagcgatcga cagcaaggcc
    19621 aaggcgtggt cacgtgaggt cgttgacgcc gtccgcgcag ggttgcagga tcgctaccag
    19681 atcgctgtcg atctcggcat cggcctcggg ctgcgccaag gcgaagcatt cggtctcgcc
    19741 gaagaggact tcgacttcgc ggctggagtc gttcacatcc gccgccagct caggtgggac
    19801 atcaaggggc gtccctactt ctcgctcccc aaggggcgta agacccgcga ggtccccctg
    19861 ccggccaatc tcgtgcttcg ggcccgagat cacttccgcc ggttcccttc gacttcctcc
    19921 acgctgccct ggcggaaccc ggaggccccc accaccgcgc tcgaagagcg ccagcgaaag
    19981 ccgatcacgg tcgacctgat cctcacctcg tctcacggca accgcatcta ctaccgcacc
    20041 tggaacgacc gcagctggaa gcgtgcgctc gccgccgccg ggctgatcaa gcccgtgggc
    20101 gagaaggtgc gacacgacgg caaccgggtt cggcgggtcc cgtgctacgc cgctccgcgc
    20161 gaggacatgt ttcacgtcct ccgccacacg tatgcgagcg tgcagctgga ggccggcgag
    20221 tcgatcgtca gcctctccaa gtggctgggg cactcgacgc cgaaggtcac cctcgaccac
    20281 tacgctcact tcatgcccgg cgcggggcag cgcggcctcg ccgccatgga cgcctggctg
    20341 caggatccct cgcggccgaa agtccctgag aagtccctgc cggtaccaag catccctcgg
    20401 ctacccacga acatgcaggt caagggtatg gtgcgacagg gggacgacat gtccgtgaag
    20461 tacaaggaga cggcccgggg cgggctggcg gtcaacatca tcgagtgctg agcgccggcc
    20521 tcccggccgc ctcaccccgg ggtcgggctc cgtccggaga ggtcgtcccc ggagggggga
    20581 ccgctcaagg cttccgtgcc accagcccgt actgcgggac ctcctcgggg agggcgccgt
    20641 ccgggcccgg tgtcgcgcgc cagcgggagc aggagacgat gccgggctcc agcagttcca
    20701 ggccgtccag gagtccggtg aggtcggcgg cggagcgggc ggtgatgggg ggcttggcgt
    20761 tggcgttcca gaaggccatg gcctcggcgt tggcggtgcc gcccagttcc agggtggggt
    20821 gggtgagcgc gaggtggctg ccggagggga gcgcgtcgac caggtggcgg acgatgcggc
    20881 gggcctcggt ggtctcggag acgaagttga ggatgccgag cagcatcacc gcgaccggcc
    20941 gggtcaggtc cagggtgcgg gcggccccgg cgagaatcgc cgcggggtcg tgggcgtcgg
    21001 cgtccaggta ggaggtggcg ccctcggggg tgccggcgag cagggcgcgg gcgtgggtga
    21061 ggacgatcgg gtcgttgtcg acgtagacga cccgggcgcc ggggtcgatg cgctgggcga
    21121 cctcgtgggt gttgtcgacg gtgggcagtc cggtgccgac gtccaggaac tgggcgacgc
    21181 ccgcctcccg gaccaggtac gtcacggccc ggccgaggaa ggcgcggtcg gcccgggcca
    21241 cgtcgcggat gccggggtgg aacccggcga cctgctcgcc gacctcggcg tcggcggcgt
    21301 agtggtcctt gccgccgagc cagtagttcc agacccgggc gttgtgcgcg atccgctgcc
    21361 cgtcccgcac cacctcggtg tcccccggtc cccgctgccc ctccaccgct ccgccgccac
    21421 tcaccacgtc gcccctctca cctcgtccgt ccccgctgcc tcacggggtc tccatcatgg
    21481 cggaacgatc aactcggctg cggagcaggg tagttgtccg aatccgggag ggctcccccc
    21541 ggccccgccg cagccttcgg cgccgcacgc gcccgacctc gcctttcgct cctttccgta
    21601 gaacacgcgg aactcttcgt cacctccggc ggcggtcgcg tcagattccc gtcaagggtt
    21661 cggccgcgct cgtatggacc ccgtcaaaat ggcgcaccac ccggtcggcg gtgaggtttc
    21721 ctctt
//
