LOCUS       NZ_CP106650            11368 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Streptomyces sp. GBA 94-10 4N24 strain GBA 94-10 chromosome,
            complete genome.
ACCESSION   NZ_CP106650
VERSION     NZ_CP106650.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GBA 94-10 4N24
  ORGANISM  Streptomyces sp. GBA 94-10 4N24
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7025021)
  AUTHORS   Ian,E., Malko,D.B., Sekurova,O.N., Bredholt,H., Ruckert,C.,
            Borisova,M.E., Albersmeier,A., Kalinowski,J., Gelfand,M.S. and
            Zotchev,S.B.
  TITLE     Genomics of sponge-associated Streptomyces spp. closely related to
            Streptomyces albus J1074: insights into marine adaptation and
            secondary metabolite biosynthesis potential
  JOURNAL   PLoS One 9 (5), e96719 (2014)
   PUBMED   24819608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025021)
  AUTHORS   Ruckert,C., Busche,T. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-SEP-2022) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
REFERENCE   3  (bases 1 to 7025021)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-NOV-2021
            Assembly Method                   :: flye v. 2.9-b1768
            Assembly Name                     :: GB94_v2
            Genome Coverage                   :: 229.4x
            Sequencing Technology :: Illumina MiSeq;Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495635.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 06:31:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,298
            CDSs (total)                      :: 6,204
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 100 of 216
            Pseudo Genes (incomplete)         :: 164 of 216
            Pseudo Genes (internal stop)      :: 24 of 216
            Pseudo Genes (multiple problems)  :: 67 of 216
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:13:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6531676
            Orig. end                         :: 6543044
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106650.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Wittmann Lab, Saarland
            University, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="24"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            274..1329
                     /locus_tag="B591_RS29155"
                     /old_locus_tag="B591_28904"
     CDS             274..1329
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894130.1"
                     /locus_tag="B591_RS29155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28904"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_037788141.1"
                     /transl_table=11
                     /translation="MSAARTAAPVLRRGWTGTGLKAAVLMVLALAAGAAGLVAGPAVTT
                     ADVAEVLAGGGDPLARHIVLNLRLPRALVAVTAGACLALAGLVLQSALRNPLAGPEVTG
                     VTPGAVLGAVTATGLGLAGWQSPTAVLVAACLGGCAGAGLLWLLAGRERGDPEQTAVHG
                     VLVSAVLTGATAVVLLIAPGELGSVVQWLVGSTEGRVWRHWELLWPWALCWGAVAWLLA
                     GPLTLMRCGDEQAAALGLDTGRARAAALACAVALTAGAVSAVGALGFVGLLVPHVALAV
                     FGADLRATLPGAALLGAVVVGGADAGAQLLSRALAQALDADRLTVPVGALTTCAGAALL
                     LIVARRRADLR"
     misc_feature    1393..1408
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     gene            1451..2287
                     /locus_tag="B591_RS29160"
                     /old_locus_tag="B591_28909"
     CDS             1451..2287
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="B591_RS29160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28909"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023423284.1"
                     /transl_table=11
                     /translation="MDHREPGAVVAEGLRFGYPGREVLRGVDLRIGAGELVALVGLNGC
                     GKSTFLRLAAGLLRPDGGRVLLDGEEVARLSRRGAARRVALLHQSAPPVPGLTVRQLVR
                     QGRYAARGPLGMLRDGDDAVSARALADAGVADWAGRPVDALSGGERQRVRLAMALAQGT
                     RILLLDEPTTYLDLRHQLEVLQTVVRLRAERGLTVVMVVHDLNHAARFADRIVALRDGR
                     VAADGKPADIVTPALLADVLGVEGRVAPDERGGWPVCYPDHPLESASHLRNENHIH"
     gene            2356..2490
                     /gene="amiA"
                     /locus_tag="B591_RS29165"
                     /old_locus_tag="B591_28914"
     CDS             2356..2490
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="B591_RS29165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28914"
                     /product="streptamidine family RiPP"
                     /protein_id="WP_008409986.1"
                     /transl_table=11
                     /translation="MEHDKVFAPIADPGQLAHLSATHSNALVENPFDDADEAGAADDK"
     gene            2633..3478
                     /locus_tag="B591_RS29170"
                     /old_locus_tag="B591_28919"
     CDS             2633..3478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470988.1"
                     /locus_tag="B591_RS29170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28919"
                     /product="hypothetical protein"
                     /protein_id="WP_023423285.1"
                     /transl_table=11
                     /translation="MTSSRLAPGAGIVTVPGGRPAVRTAEGEFLHLDTGAADLAALTRR
                     LVSGEAAPDAEVARVAAAFEREGHAVRPASEEGGRLTGRTVLLLGDARLTGPLARYATA
                     EGALARHATPEHVARLADGEGADASTAVVWCLDEPVPPGLWDVADRLPAHGTAWLRCHR
                     EGAHLWTEPLAAAPGDVTSAHVRLRRLAATSAHRQLAAYWAGHRTPDNGPHPGEAAAAL
                     VAALLTADLLAWAVPGPNSGLPARRRLRRVDLRDLTVTEHPVLPVPPVAPLPGRESGPA
                     "
     gene            3475..5004
                     /locus_tag="B591_RS29175"
                     /old_locus_tag="B591_28924"
     CDS             3475..5004
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639446.1"
                     /locus_tag="B591_RS29175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28924"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_023423286.1"
                     /transl_table=11
                     /translation="MTPATTRLATPDGTTLATDLHLPATPGPRPAVLIRTPYDRRAHRA
                     ELRGWAERGFAAVAQDVRGRHGSAGEWHPYRDQEAEDGVATLDWIRAQPWSDGRVVAAG
                     ASYAAYCALAAALSPGAPGPDAVIAAVPALGLTETAREPTGPERLWARLGWWAAHGDRP
                     DSAPDALARTLARDPRLPEHLPLTRIADRLDRPLPSWPALWQDCRRGRLVAHGSAARLP
                     LLAVGGTRDPFAEDTVALWRGWGGPARLLLGPWGHTLTAGTRPGTPGRLDLGALYARWA
                     RAALDGEIGPGRRGVIGLAQSGRWHHLTDSVTRPGGHEVTGAVWRFGAADGLRLLAGAE
                     FTADPDRPVRSDDLTVPRGRTPADRCLLATPPLPRPLDLAGSAEARLTVVADTPRADWA
                     VRVVALDPAGRADPLAFGIVRRDAPPGTPHPVTVPLGTLGRTLAAGTTLRVEIAGHHFP
                     AHARNPHTGEDPVTATRLAASRRTVRTEGSALHLPVAGRPRPVDPVPETCR"
     gene            5001..6368
                     /locus_tag="B591_RS29180"
                     /old_locus_tag="B591_28929"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="B591_RS29180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28929"
                     /product="YcaO-like family protein"
                     /protein_id="WP_023423287.1"
                     /sec_met_domain="YcaO (E-value: 6.2e-44, bitscore: 149.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAALPLDALVDPHCGLVRDVAPVPHPEGAPPRYTAMTAHVADAR
                     RFGAWPADRVSLGTTFGDPAGAWTAAVAEAVERYCGNRLPPPGHPDAPRRATAAQLTAE
                     GHQVYGPDDVPAYAPWQYRRPAFPYAPFTPDTPALWARGTENGRDCWAPVALTHLNWRQ
                     GELRSLPRTHHLNYAGIATGQGLADAAERALLEVVERDALELWWHLDGPTRGIDPSSVP
                     GLDADLAGCGLEVSIVEMPSEFAPCVAALVHDARRGVHAAGFACRFDPAEAARKAVLEA
                     VHTWVFTLGAEAADGWVHQAVEAGVLARGLYLDHRADRRYLDDCGEEFAAVRDLGAHVQ
                     AWLDPRLAPLARRFTAPALGTVPVAELAHGSRDRLDTALAEGGHRVLTFDLTTEDVAET
                     ALRVARVLVGGLVPNAPAAFGYYGCPRFATAAPARGWRSQPPREPGDFTLAPAPHM"
     gene            6382..7689
                     /locus_tag="B591_RS29185"
                     /old_locus_tag="B591_28935"
     CDS             6382..7689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508299.1"
                     /locus_tag="B591_RS29185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28935"
                     /product="nitroreductase"
                     /protein_id="WP_265668182.1"
                     /transl_table=11
                     /translation="MTTDAILGHALALARSPRTPARATPPPRRPYPWTGTPLALPTTAP
                     DPDGPVDLDHLLRHALRARPGTGGRLRPAASAGALHPVRAHLLIGPGCTLPPGRYAYDP
                     EVHRVFRRGPAPHGAAPGMIAVLTATAERTAAHYGHRAWPLLLLDTGHAAAALALAPQG
                     PGVRVSLDADADTLAAAAGLPPADRWQRIRPGTETEHPLAAVQLTPRRTQCTTPALDRW
                     SALPLPDRTRTPTRPPARPCGTGRLLELLGAATGTEPTWHPVRRPDAVTGRALLDRRSA
                     DPAALGHPPDGGTVARILRTAATAWPGGPAWCAAVAAPTPALFAPGHRTADPHRLARGD
                     ARPSLAHWAAGQLWLADTGAVLLAHGCPSDAPAHQVRQDHLAAGFAAGTAHAHAAAEGI
                     AARPVGSWQQADLGAALGETPGRDWVLHGLALGAAR"
     gene            7748..9493
                     /locus_tag="B591_RS29190"
                     /old_locus_tag="B591_28944"
     CDS             7748..9493
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894136.1"
                     /locus_tag="B591_RS29190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28944"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_023423290.1"
                     /transl_table=11
                     /translation="MIPPPELRRAARPAALPLAGATALLALVGATHIGQAVLLALVLAR
                     VARGETAGLPALLAAVAAVVLARALLGRAQRLLAVRAGALVRVRLRDDLLAHLGGTGPG
                     ALAGARAGAVRATLVDGVEGVDAYVSRHLPHLIVTCALPPLLLVAVALVEPYAVAALAP
                     ALLLALAGPRLWDRLLARRGREHWDSYEALAADHLEALQGMAALRAAGAVGRTRARLER
                     RSAALHRATVAKMRVSLADTGLTDLAVQGGTVAAVLVACAAATTGGTTATGTYLLLMLA
                     SECFRPVRDLSREWHAGHLGLSAVDGIAALRHAEGGVPDEGTATADWATPPEVRFENVH
                     FTHPGRIRPALAGVAFTAPAGRVTALVGPSGAGKSTLLSLLLRQRDPDSGRVTVGGLDT
                     AAYRLDALRRGIAVVSQDTYLFRATVADNLRLARPAATSAQLHEAARAAGIHEELTRLP
                     DGYDTVIGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDERAEARITRELLAA
                     GRGRTCLLVAHRLEAVRHADHIVVLDHGRVDAAGTHSELLAADGLYARLVAAGRTVTPM
                     QQEAA"
     gene            9490..11274
                     /locus_tag="B591_RS29195"
                     /old_locus_tag="B591_28949"
     CDS             9490..11274
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470983.1"
                     /locus_tag="B591_RS29195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_28949"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023423291.1"
                     /transl_table=11
                     /translation="MTPPTPPEPPAGPPPHKALRSLLPVLAAHRAMTARTCAAALVDQA
                     ALVVLVTLAAHTVGTAVIDGRPPSAATMALLVALAAVRALATWREMDLSHDLAYRVLAL
                     LRVRVFDGIARSAPARVAGRRSGDLASTALGDVEALEFFYAHALAQLLATGTVFTVSAA
                     LLGTREPWLLALVLPAAALLLALPVLDGRGRAARGARTRAALADLSAETVETVDGLREL
                     LAFGALNRRRARLRAYGRRLARAQRAEQSWEAGAAALRDLLVVAAVIGVVAVAGHSAVE
                     GRLHGAWTPAAMALALGALAPVADAAASLGQAGSLRAAAARVRAAADAPAGAPAPSTPR
                     PLPEGPLGLRLRGVRFGYGGTPVLDGVDLTVRPGETVALVGASGAGKSTCAHLLARYWD
                     PQEGTVTLVPEDGRPPVALRDLGDAELRSAVAVVGQEAPLFHGTLAENLLLAAPDAPPD
                     ALDRAVRACGVDTLAAGLPDGLGTAVGERGATLSGGQRARVALARALVAAPRVLVLDET
                     TAHLDHTGDAELAAALAASAPGRATLVIAHRPATVRRADRVAVLEDGRIVEEGTWEELA
                     SAGGALTRLLSREATATA"
ORIGIN
        1 cggcttcctc gccccgcacc tggcccggcg actgcggccc ggcgccgacg cggcggggct
       61 gctcgggtac gcggccgcct gcggcgccgt cgtcgtggtc tgcgccgacc tgcccgcccg
      121 gctgctgctc gcccccgtcg agaccccggt cggcgcctgg accgccctgt tcggggtgcc
      181 ggtcggcgtg gccctgctca aatggcgcgc gcccgcccgc agttcaccgg cccccgcgcc
      241 cggcgaccgg gccgccctgc ggaaggccga gcggtgagcg ccgcgcggac cgccgcaccg
      301 gtgctccgga ggggctggac cggcaccggg ctcaaggcgg ccgtcctgat ggtcctcgcc
      361 ctcgcggccg gggcggcggg gctcgtggcc gggcccgccg tgaccacggc cgacgtcgcc
      421 gaggtgctcg cgggcggcgg cgatccgctc gcccggcaca tcgtgctcaa cctccgtctg
      481 ccgcgcgccc tggtcgccgt caccgccggg gcctgcctcg cgctggccgg gctggtcctc
      541 cagtcggccc tgcgcaaccc gctggccggt cccgaggtca ccggtgtcac cccgggcgcg
      601 gtgctcgggg cggtcaccgc gaccggactc ggcctcgccg gctggcagtc gcccaccgcc
      661 gtgctggtgg ccgcctgcct cgggggctgc gccggggccg ggctgctctg gctgctcgcc
      721 gggcgagagc ggggagaccc cgaacagacc gccgtccacg gcgttctggt ctccgccgtg
      781 ctgaccggcg ccaccgccgt ggtgctgctg atcgcccccg gcgaactcgg cagcgtcgtg
      841 cagtggctgg tcggctccac cgagggacgc gtctggcggc actgggaact cctgtggccg
      901 tgggccctgt gctggggcgc cgtcgcctgg ttgctggccg ggccgctgac gctgatgcgg
      961 tgcggcgacg agcaggccgc cgcgctgggc ctcgacaccg ggcgggcccg cgccgccgcc
     1021 ctggcctgtg cggtggcgct caccgccggg gcggtctcgg cggtgggcgc gctcggcttc
     1081 gtggggctgc tggtcccgca cgtcgcactc gccgtcttcg gcgccgacct gcgagccacc
     1141 ctgcccggcg ccgctctgct cggcgcggtc gtggtgggcg gcgccgacgc gggggcccaa
     1201 ctgctctccc gtgccctggc ccaggccctg gacgcggacc ggctcaccgt ccccgtgggc
     1261 gccctgacca cctgcgcggg cgccgccctg ctgctgatcg tggcccgccg ccgcgccgac
     1321 ctgcgatgag cgggcggcac cgcacgcccc cgaggcgtac cgaagcacgg ccgtgcgggc
     1381 gaccgcgccg ccggcaccga cgagtcacgg ccccgcccgg cgagcgcggg cggggccgga
     1441 aggaggagtg atggaccatc gggaacccgg tgccgtggtc gcggaagggc tgcggttcgg
     1501 ctatccggga cgcgaggtgc tgcgcggggt cgacctgcgg atcggcgcgg gcgaactggt
     1561 cgcactggtc ggcctcaacg gctgcggcaa gagcaccttc ctgcggctcg ccgccgggct
     1621 gctgcgcccg gacggcgggc gggtcctgct ggacggggag gaggtggcac ggctctcccg
     1681 ccggggcgcc gcccgccgcg tcgccctcct ccaccagtcg gcgccgcccg taccggggct
     1741 gaccgtccgc cagctggtcc ggcaggggcg gtacgccgcc cgggggccgc tcgggatgct
     1801 ccgtgacggg gacgacgcgg tgagtgcgcg ggcgctggcc gacgccgggg tcgccgactg
     1861 ggccgggcgg ccggttgacg cgctctccgg cggtgagcgg cagcgtgtgc ggctggccat
     1921 ggcgctggcc cagggcaccc ggatcctgct gctcgacgaa ccgaccacct acctggacct
     1981 caggcaccag ctggaagtgc tccagaccgt ggtccggctg cgcgcggaac gcggtctgac
     2041 ggtggtgatg gtggtgcacg acctcaacca cgccgcccgt ttcgccgacc ggatcgtcgc
     2101 cctccgggac ggccgggtgg ccgccgacgg caagcccgcc gacatcgtca ctcccgccct
     2161 cctcgccgac gtgctgggtg tcgaggggcg ggtggcgccg gacgagcggg gcggctggcc
     2221 ggtctgttac ccagatcacc ctctggagag cgcaagccac ttgcgcaatg aaaatcatat
     2281 tcattaaggt ccgtggtgcg gcaggcgcca cgccgttcac gtccaccacg catcgaaccg
     2341 aatggagctc aactcatgga gcacgacaag gtgttcgccc cgatcgccga cccgggccag
     2401 ctggcccacc tctccgccac ccactccaac gccctcgtcg agaacccctt cgacgacgcc
     2461 gacgaggccg gtgccgcgga cgacaagtag tcagccccgg ccgccggtga cggcggccgg
     2521 ctgacacccg tgacgggccc gcccggcgaa cccccgggcg ggcccgttgc gttcggcgcc
     2581 ccacggcacc ggcgccgccc atcccctcgt actccatccg acggaggttt ccgtgaccag
     2641 cagccgactc gccccgggcg ccgggatcgt caccgtcccc ggcggccggc ccgccgtacg
     2701 caccgccgag ggcgagttcc tgcacctcga caccggcgcc gccgacctcg ccgcgctcac
     2761 ccgccgcctg gtgagcggcg aagccgcccc cgacgccgaa gtggcgcgcg tcgcggcggc
     2821 gttcgagcgc gagggtcacg cggtccggcc cgcctctgaa gagggcggcc ggctcaccgg
     2881 ccgtaccgtc ctgctgctcg gcgacgcgcg gctcaccggc ccgctcgccc ggtacgcgac
     2941 cgccgaaggc gccctggccc ggcacgccac ccccgagcac gtcgcccggc tcgccgacgg
     3001 tgaaggggcg gacgcgtcga ccgccgtcgt ctggtgcctc gacgagccgg tgccgcccgg
     3061 gctctgggac gtcgccgacc ggctccccgc acacggcacg gcctggctgc gctgccaccg
     3121 cgagggcgcc cacctgtgga ccgaaccgct cgccgccgca cccggcgacg tcacctccgc
     3181 ccacgtccgc ctccgccgcc tcgccgccac ctccgcccac cgccagctcg ccgcctactg
     3241 ggccggacac cgcacccccg acaacggccc gcaccccggc gaggccgccg ccgccctggt
     3301 cgccgccctc ctcaccgccg acctcctcgc ctgggccgtg ccgggcccga actccgggct
     3361 ccccgcgcga cgcaggctcc gccgcgtcga cctgcgcgac ctcaccgtca ccgaacaccc
     3421 cgtgctgccc gtaccgccgg tggccccgct gcccggccgg gaaagcggcc cggcatgacg
     3481 cccgcgacca cccgcctcgc cacccccgac ggcaccaccc tcgccaccga cctccacctc
     3541 cccgccaccc cgggcccccg ccccgccgtg ctgatccgca ccccgtacga ccgccgcgcc
     3601 caccgggccg aactgcgcgg ctgggcggag cgcgggttcg ccgccgtcgc ccaggacgtg
     3661 cgcggccggc acggctcggc gggggagtgg cacccgtacc gcgaccagga ggcggaggac
     3721 ggcgtggcca cgctggactg gatacgcgcc cagccgtgga gcgacggccg cgtggtcgcc
     3781 gccggggcct cgtacgccgc gtactgtgcc ctcgccgctg ccctctcccc cggcgccccc
     3841 ggcccggacg cggtgatcgc cgccgtcccc gccctcggcc tgaccgagac ggcccgcgaa
     3901 cccaccggac ccgaacgcct gtgggcgcgc ctcggctggt gggcggccca cggcgaccgg
     3961 cccgactccg cacccgacgc cctcgcgcgc accctcgccc gcgacccgcg cctgcccgag
     4021 cacctgccgc tgacccggat cgcggaccgg ctcgaccgcc cgctcccctc ctggcccgcg
     4081 ctgtggcagg actgccggcg cggccgcctg gtcgcccacg gctccgccgc ccggctcccg
     4141 ctgctcgccg tcggcggcac ccgcgacccc ttcgccgagg acaccgtcgc cctctggcgc
     4201 ggctggggcg gccccgcccg gctgctgctc ggcccctggg gccacacgct cacggcgggg
     4261 acccgccccg gcaccccggg ccgcctcgac ctcggcgccc tctacgcccg ctgggccagg
     4321 gccgcgctcg acggggagat cggccccggg cggcgcggcg tcatcggcct cgcgcagagc
     4381 ggacgctggc accacctcac ggactccgtg acccggccag gagggcatga agtgaccggc
     4441 gccgtgtggc ggttcggtgc cgccgacggc ctgcgcctcc tcgccggagc cgagttcacc
     4501 gccgacccgg accgtcccgt acgctccgac gacctcaccg tcccgcgtgg gcgcaccccc
     4561 gccgaccgct gcctgctcgc caccccgccg ctgccacgcc ccctcgacct ggcgggctcc
     4621 gccgaggccc ggctcaccgt cgtcgcggac acgccccgcg ccgactgggc cgtacgagtc
     4681 gtcgccctcg acccggccgg acgcgccgac cccctcgcct tcggcatcgt ccggcgcgat
     4741 gccccgcccg gcaccccgca tcccgtcacc gtgccactcg ggaccctggg gcggaccctg
     4801 gccgccggga ccaccctgcg cgtcgagatc gccggccacc acttccccgc gcacgcccgc
     4861 aacccgcaca ccggcgagga ccccgtcacc gccacccgcc tggccgcctc ccgccgcacc
     4921 gtccgcaccg agggcagcgc cctccacctg cccgtggccg gccgcccccg ccccgtcgac
     4981 cccgtaccgg agacctgccg atgaccgccg ccctgcctct cgacgccctc gtggaccctc
     5041 actgcggact cgtccgcgac gtcgcccccg tcccgcaccc ggagggcgcg ccgccgcgct
     5101 acaccgccat gaccgcgcac gtcgccgacg cccgccggtt cggggcctgg cccgccgacc
     5161 gggtctcgct cggcaccacc ttcggcgacc cggccggcgc ctggaccgcc gccgtcgccg
     5221 aagccgtcga acggtactgc ggcaaccggc tcccgccacc cggccacccc gacgcacccc
     5281 gccgcgccac cgccgcccag ctcaccgccg agggacacca ggtgtacggc ccggacgacg
     5341 tgcccgccta cgcgccctgg cagtaccgcc gccccgcctt cccctacgcc ccgttcacgc
     5401 ccgacacccc cgcgctttgg gcgcgcggca cggagaacgg ccgcgactgc tgggcgccgg
     5461 tcgccctcac ccacctcaac tggcgccagg gagagctgcg ttcactgccg cgcacccacc
     5521 acctgaacta cgccggcatc gccaccggac agggactcgc ggacgccgcc gaacgcgccc
     5581 tcctcgaagt ggtcgagcgt gacgccctcg aactgtggtg gcacctggac gggcccaccc
     5641 ggggcatcga ccccagcagc gtccccgggc tcgacgccga cctcgccgga tgcggcctgg
     5701 aggtgagcat cgtcgagatg ccctcggagt tcgcgccctg cgtggccgcc ctggtccacg
     5761 acgcccggcg gggtgtccac gcggccgggt tcgcctgccg cttcgacccg gccgaagccg
     5821 cccgcaaggc cgtcctggag gccgtgcaca cctgggtctt caccctgggc gccgaagccg
     5881 ccgacggctg ggtgcaccag gccgtcgagg ccggtgtcct ggcccgcggg ctctatctgg
     5941 accaccgggc cgaccgccgc tacctcgacg actgcggcga ggagttcgcc gccgtacggg
     6001 acctcggcgc ccacgtccag gcatggctcg acccgcgcct cgcgcccctc gcccgccgct
     6061 tcaccgcacc cgctctcggc accgtccccg tcgccgagct cgcgcacggc agccgggacc
     6121 ggctcgacac cgccctcgcc gagggcggcc accgcgttct caccttcgac ctgaccaccg
     6181 aggacgtcgc cgagaccgcc ctgcgcgtcg cccgcgtcct ggtcggcgga ctcgtcccca
     6241 acgcccccgc cgccttcggc tactacggct gcccccgctt cgccaccgcc gctcccgccc
     6301 ggggctggcg ctcccaaccc ccgcgcgaac cgggcgactt cactctcgcc cccgccccgc
     6361 acatgtgacc ccgggccttc catgaccacc gacgccatcc tcggccacgc cctggccctc
     6421 gccagatcac cccgcacccc ggcccgcgcc accccgcccc cgcgccgccc ctacccctgg
     6481 accggcaccc cgctcgccct ccccaccacc gcccccgacc ccgacggccc cgtcgacctc
     6541 gaccatctgc tccgccatgc gctgcgcgcc cgccccggta ccggtggccg gctgcgcccc
     6601 gccgcctccg ccggagcgct ccaccccgtc cgcgcccacc tcctgatcgg ccccggctgc
     6661 accttgcccc cgggacggta cgcctacgat cccgaggtcc accgggtgtt ccggcgcggc
     6721 ccggcacccc acggagcggc ccccggcatg atcgccgttc tcaccgccac cgccgaacgc
     6781 accgccgccc actacggcca ccgcgcctgg cccctgctgc tcctcgacac cggccacgcg
     6841 gccgccgccc tcgcactcgc cccgcaggga cccggcgtcc gcgtcagcct cgacgccgac
     6901 gccgacacgc tcgcggccgc cgccgggctg cccccggccg accgctggca gcggatacgg
     6961 cccggcaccg agaccgaaca ccctctcgcc gccgtccagc tgacgccccg ccgcacccag
     7021 tgcaccactc ccgccctcga ccgctggtcg gccctgccgc tcccggaccg cacccgcacc
     7081 cccacccggc ccccggcccg gccctgcggc accggccgcc tgctggaact gctgggcgcc
     7141 gccaccggga ccgaaccgac ctggcacccc gtccgccgcc ccgacgccgt caccggacgc
     7201 gccctgctgg atcgccgcag cgccgacccg gccgccctcg gccacccgcc ggacggcggg
     7261 acagtggccc gcatcctgcg caccgccgcc accgcctggc ccggcggccc cgcctggtgc
     7321 gccgccgtcg ccgcccccac ccccgccctg ttcgcccccg gccaccgcac cgccgacccg
     7381 caccgcctcg cccggggcga cgcccgcccc agcctcgccc actgggccgc aggccagctc
     7441 tggctcgccg acaccggagc ggtactcctc gcccacggct gtccctcgga cgcccccgcg
     7501 caccaggtcc gccaggacca cctcgccgcc ggcttcgccg cgggcaccgc ccatgcccac
     7561 gccgccgccg agggaatcgc cgcccgcccc gtcggctcct ggcaacaggc ggatctgggc
     7621 gcggccctgg gggagacccc gggacgcgac tgggtcctgc acggcctggc gctgggagcc
     7681 gcccgatgag ccgccgcccg cggcccgacc ctgaccaccc caccccgccc ggagagacgt
     7741 acccgcgatg atcccgcccc ccgaactgcg gcgcgccgcc cggcccgccg ccctgccact
     7801 ggccggcgcc accgccctgc tcgccctggt cggcgccacc cacatcgggc aggcggtgct
     7861 gctcgccctc gtcctcgccc gggtcgcccg gggcgagacg gccgggctgc ccgcgctgct
     7921 cgccgccgtg gccgccgtcg tgctggcccg cgcgctgctc ggccgcgccc agcggctgct
     7981 ggccgtccgc gccggagccc tggtccgcgt ccgcctccgc gacgacctcc tcgcccacct
     8041 cggtggaacc ggcccgggcg cgctcgccgg agcccgggcg ggagcggtgc gggccaccct
     8101 cgtcgacgga gtcgagggcg tggacgcgta cgtctcccgc catctgcccc acctgatcgt
     8161 cacctgcgcc ctcccgcccc tgctgctggt cgccgtcgcc ctcgtcgagc cgtacgccgt
     8221 ggccgcgctc gcccccgccc tcctgctggc gctcgccggg ccccgcctct gggaccggct
     8281 cctcgcccgc cggggccgcg agcactggga ctcctacgag gccctagccg ccgatcacct
     8341 ggaggccctc caggggatgg cggccctgcg cgccgccggc gccgtcggcc gcacccgggc
     8401 ccggctggag cggcgttcgg ccgcgctgca ccgggccacc gtggccaaga tgcgggtctc
     8461 cctcgccgac acgggcctga ccgacctcgc cgtgcagggc ggcaccgtcg ccgccgtcct
     8521 cgtcgcctgc gccgcagcca ccaccggggg caccaccgcg accggcacct atctgctgct
     8581 gatgctggcc tccgagtgct tccgcccggt ccgcgacctc tcccgcgagt ggcacgccgg
     8641 gcacctgggg ctgtcggccg tcgacggcat cgccgcgctg cgccacgccg agggcggcgt
     8701 ccccgacgag ggcaccgcca ccgccgactg ggccacgccc cccgaagtgc gtttcgagaa
     8761 cgtccacttc acccacccgg gacggatccg acccgccctc gccggcgtcg ccttcaccgc
     8821 cccggccgga cgcgtcaccg ccctggtcgg cccctccggc gccggaaagt ccaccctgct
     8881 gagcctcctg ctccgccagc gcgaccccga ctccggccgg gtcaccgtcg gcggcctgga
     8941 caccgccgcg taccggctcg acgcgctccg ccggggtatc gccgtggtct cccaggacac
     9001 ctacctcttc cgcgccaccg tcgccgacaa cctccgcctc gcccgccccg cagccacctc
     9061 ggcccagctc cacgaggccg cccgcgccgc cggcatccac gaggagctga cccggctccc
     9121 cgacgggtac gacacggtga tcggcgaacg cggcgccacc ctctccggcg gccagcgcca
     9181 gcgcctcgcc ctggcccgcg ccctgctcgc cgacgccccg gtcctcgtcc tcgacgaggc
     9241 caccagcgcc gtggacgaac gcgccgaggc ccgcatcacc cgggaactcc tggcagccgg
     9301 acggggccgc acctgcctgc tcgtcgccca ccgcctcgaa gccgtccgcc atgcagacca
     9361 catcgtcgtc ctcgaccacg gccgcgtcga cgccgccggt acccactccg aactcctcgc
     9421 cgccgacggc ctgtacgccc gcctggtggc cgcaggccgg accgtcaccc cgatgcagca
     9481 ggaggccgca tgaccccgcc gaccccgccg gagccaccgg ccggcccgcc cccgcacaag
     9541 gccctgcgct cgctgctgcc cgtgctcgcc gcccaccgcg ccatgaccgc ccgtacctgt
     9601 gcggccgccc tcgtcgacca ggcggccctc gtcgtcctgg tcaccctcgc cgcccacacc
     9661 gtcgggaccg ctgtgatcga cgggcggccc ccctcggcgg ccaccatggc gctgctcgtc
     9721 gctctggccg ccgtgcgggc gctggccacc tggcgcgaga tggacctctc ccacgacctc
     9781 gcctaccggg tcctggcact cctgcgcgtc cgcgtcttcg acgggatagc ccgcagcgcc
     9841 cccgcccgtg tcgccggccg ccgcagtggc gacctcgcct ccaccgcgct gggcgacgtc
     9901 gaggcgttgg agttcttcta cgcccatgct ctcgctcaac tcctcgccac cggaacggtg
     9961 ttcaccgtct cggcggccct gctgggcacc cgcgaaccct ggctgctggc cctcgtcctg
    10021 cccgccgccg cgctcctgct cgccctgccc gttctcgacg gacgtggccg cgccgcacga
    10081 ggagcccgca cccgcgcggc cctcgccgac ctctccgccg agaccgtgga gaccgtcgac
    10141 gggctgcgcg aactcctcgc cttcggcgcg ctgaaccgcc ggcgcgcccg gttgcgcgcg
    10201 tacgggcggc ggctggcccg agcgcaacgg gccgagcagt cctgggaggc cggtgccgcc
    10261 gccctgcgcg acctgctggt ggtggccgcc gtgatcggcg tcgtcgccgt cgccggccac
    10321 agcgccgtcg agggccgcct gcacggcgcc tggaccccgg ccgccatggc gctggcgctc
    10381 ggcgccctcg cccccgtcgc cgacgcagcc gcctcgctcg ggcaggccgg cagcctgcgg
    10441 gccgccgccg cccgggtccg ggccgccgcc gacgcccccg ccggagcccc cgcgccgagc
    10501 acgccgcgcc cgctgcccga gggcccactc ggcctccggc tgcgcggcgt gcggttcggg
    10561 tacggcggca cgcccgtgct cgacggggtg gacctcaccg tccgcccggg cgagaccgtc
    10621 gccctggtcg gcgcctccgg cgcgggcaag tccacctgcg cgcacctgct ggcccgctac
    10681 tgggaccccc aggagggcac cgtcaccctc gtccccgagg acggacgacc gccggtcgcc
    10741 ctgcgagacc tgggcgacgc cgagctgcgg agcgccgtcg ccgtcgtcgg ccaggaagcc
    10801 cccctcttcc acggcaccct cgccgagaac ctgctgctgg ccgcccccga cgccccgccg
    10861 gacgcgctgg accgcgcggt acgggcctgc ggcgtcgaca ccctcgccgc cggactcccc
    10921 gacgggctgg gtacggccgt gggggagcgg ggtgccaccc tctccggtgg gcagcgggcc
    10981 cgggtcgccc tggcgcgggc gctggtcgcc gctccccgcg tactggtcct ggacgagacc
    11041 acggcccacc tggaccacac gggggacgcg gaactcgccg ccgccctcgc cgcctcggcc
    11101 cccgggcgcg ccacgctggt catcgcccac cggcccgcca ccgtgcgccg ggccgaccgc
    11161 gtcgcggtcc tggaggacgg ccggatcgtg gaggagggca cctgggagga gctggcgtcc
    11221 gccggcggcg cgctgacacg cctgctctcc cgggaggcga cggcaaccgc ctgacctgtg
    11281 ccgacgcgca cgcccgcgtg cacgtggaag ggccggggtc cctcgcgggg accccggccc
    11341 tgtcgtccgg gggaggaatg ctgcggct
//
