LOCUS       NZ_CP106650            29821 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Streptomyces sp. GBA 94-10 4N24 strain GBA 94-10 chromosome,
            complete genome.
ACCESSION   NZ_CP106650
VERSION     NZ_CP106650.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GBA 94-10 4N24
  ORGANISM  Streptomyces sp. GBA 94-10 4N24
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7025021)
  AUTHORS   Ian,E., Malko,D.B., Sekurova,O.N., Bredholt,H., Ruckert,C.,
            Borisova,M.E., Albersmeier,A., Kalinowski,J., Gelfand,M.S. and
            Zotchev,S.B.
  TITLE     Genomics of sponge-associated Streptomyces spp. closely related to
            Streptomyces albus J1074: insights into marine adaptation and
            secondary metabolite biosynthesis potential
  JOURNAL   PLoS One 9 (5), e96719 (2014)
   PUBMED   24819608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025021)
  AUTHORS   Ruckert,C., Busche,T. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-SEP-2022) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
REFERENCE   3  (bases 1 to 7025021)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-NOV-2021
            Assembly Method                   :: flye v. 2.9-b1768
            Assembly Name                     :: GB94_v2
            Genome Coverage                   :: 229.4x
            Sequencing Technology :: Illumina MiSeq;Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495635.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 06:31:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,298
            CDSs (total)                      :: 6,204
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 100 of 216
            Pseudo Genes (incomplete)         :: 164 of 216
            Pseudo Genes (internal stop)      :: 24 of 216
            Pseudo Genes (multiple problems)  :: 67 of 216
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:13:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4769414
            Orig. end                         :: 4799235
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106650.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Wittmann Lab, Saarland
            University, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..29821
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="19"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..29821
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29821
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:15821](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(14001..15821)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     gene            complement(422..1345)
                     /locus_tag="B591_RS21095"
                     /old_locus_tag="B591_20938"
     CDS             complement(422..1345)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948204.1"
                     /locus_tag="B591_RS21095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20938"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_023419311.1"
                     /transl_table=11
                     /translation="MSIAPSPAREDSAPRPLATPPEKRSRRPRRSGAGRQLHGGRITYA
                     VLGVVTVISLFPLVWTAIAASRNNTRLAETPPPFWFGGNLFKNLEIAWTDANMGSALLN
                     TVVVAGTVSVGTVLFSTLAGFAFAKLRFRFKNALLLLVIGTMMVPPQLSVVPLYMMVAK
                     LSWSDQLQAVILPTLVTAFGVFFMRQYLLQALPTEIIEAARVDGANSLRVLWHVVFPAA
                     RPAMAVLGMLTFVQSWNDFFWPIIALTQNGSPTVQVALTGLGRGYIPDQSVIMAGALLG
                     TLPLLIAFVVFGKQIVGGIMQGAVKG"
     gene            complement(1342..2391)
                     /locus_tag="B591_RS21100"
                     /old_locus_tag="B591_20943"
     CDS             complement(1342..2391)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468241.1"
                     /locus_tag="B591_RS21100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20943"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_023419312.1"
                     /transl_table=11
                     /translation="MASEFPAAAPSSVEEGAAAHASGVAVASRPPQDPGRKAADRRRRE
                     RRSRWYRRDVKWSPYAFIAPFFLFFAAFGLFPLLYTGWASLHRVELTAPNDMEWIGLRN
                     YTRLLDDDFFWNALQNTFTIGILSTVPQLLMALGIAHLLNYRLRGSMFFRVAALTPYAT
                     SVAAATLVFVMLFGRDYGMINWVLSLLGFEHIDWQNGSFTSQLAVSSIVVWRWTGYNAL
                     IYLAAMQSIPSDLYESAALDGASRWQQFLHVTLPSLRPTILFTVVVSTIGAIQLFGEPL
                     LFNGGGGATGGSDHQFQTLGLYLYEQGWTNLHLGRASAIAWAMFLLLIVIGLVSLAVTR
                     WLRRGEGKA"
     gene            complement(2398..3726)
                     /locus_tag="B591_RS21105"
                     /old_locus_tag="B591_20948"
     CDS             complement(2398..3726)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983266.1"
                     /locus_tag="B591_RS21105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20948"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_023419313.1"
                     /transl_table=11
                     /translation="MRTRSRTARKAVVLAAVAALGTSLLAGCASDDEPEAAGSEAGSDK
                     GKTTLTVGVFGAFGLKEAGLYEQYMKENKDVVIKQTSIERNENYYPQLLTHLGTGSGLA
                     DIQAVEVNNIAEVVQTQGDKLEDLSKAPGADKDAFLKWKWDQGTTKAGKTVALGTDIGP
                     QAICYRKDLFEKAGLPTDREEVGKLWAGDWGKYLEAGKEFQKNAPKGAKFVDGAPGVMA
                     AVTGSSAIRYYDDKGEVVYKSNPAVKEAWDLAAEFATEGLTAKLQQFTPSWNQGFSNGS
                     FATVSCPAWMLGYIQDKGGEKNADKWDIAQAPKPGNWGGAFLTVPSAGKNKEEAAKLAA
                     WLTAPEQQAKFFAERGSFPSAQAAYDLPEIADAKHEYFDDAPIGKILAQAAEGAPVQIL
                     GPKDLVIAQNLADVGMLQVDQKGKSSEEGWKAAVKAIDNALDQ"
     misc_feature    complement(3840..3854)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    3841..3855
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: strong, score: 28.65"
                     /tool="antismash"
     misc_feature    3924..3941
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            4000..5055
                     /locus_tag="B591_RS21110"
                     /old_locus_tag="B591_20953"
     CDS             4000..5055
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638131.1"
                     /locus_tag="B591_RS21110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20953"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_023419314.1"
                     /transl_table=11
                     /translation="MTAGRSNGRSGGRPTLEEVAARAGVGRGTVSRVINGSPRVSETTR
                     AAVEAAVAELGYVPNTAARALAANRTDAIALVVPEPETRFFTEPYFSDILSGIGAALAP
                     TDLQLLLTFADGARERRRLAQYLAAHRVDGVLLVSVHEDDPLPDLLSQLEIPAVISGRR
                     SENEPLASVDTDNYSGARAAVTHLLERGRTTIATISGRLDVYGAQRRLDGYRSALGDAG
                     RPPEDSLVAAGDFTEEGGRQAMRLLLDRRPELDAVFACSDVMAAGARQVLREAGRRIPE
                     DVALVGFDDSAVARLMDPPLTSVRQPTAAMGRAMTEALLAEIAEGRPDSSRLRRPRQVV
                     LDTELVVRASS"
     gene            5230..5457
                     /locus_tag="B591_RS21115"
                     /old_locus_tag="B591_20958"
     CDS             5230..5457
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948199.1"
                     /locus_tag="B591_RS21115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20958"
                     /product="hypothetical protein"
                     /protein_id="WP_023419315.1"
                     /transl_table=11
                     /translation="MELPDYLIRLQRAADDEGRRLEHLDEDERDAARRLYFNAAAEVDV
                     AVRDFAATAGLDRHTVEKEVRQRARQPPAE"
     gene            5498..5668
                     /locus_tag="B591_RS21120"
                     /old_locus_tag="B591_20963"
     CDS             5498..5668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468238.1"
                     /locus_tag="B591_RS21120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20963"
                     /product="hypothetical protein"
                     /protein_id="WP_023419316.1"
                     /transl_table=11
                     /translation="MNTRTDTAPRPAAVVNTEIRALLMRRGGLAPAERAAYERLLVEWA
                     QAVRAEVVVAA"
     gene            5700..5843
                     /locus_tag="B591_RS21125"
     CDS             5700..5843
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B591_RS21125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158698060.1"
                     /transl_table=11
                     /translation="MIDNGRRRHLLCARCGISLRADEVTAPDPALLRARADRWRQVWRR
                     TV"
     gene            complement(5859..6509)
                     /locus_tag="B591_RS21130"
                     /old_locus_tag="B591_20968"
     CDS             complement(5859..6509)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B591_RS21130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B591_20968"
                     /product="hypothetical protein"
                     /protein_id="WP_023419317.1"
                     /transl_table=11
                     /translation="MSASQSAVAATLLDRHGTTYAREAGITLKDTPQPLYQLLVLSSLL
                     SARIRASVAVAAAGALFHDGMRNPRAMADASWQERVDALGEGGYRRYDERTATQLGEGA
                     ERLLEEHRGDLRRIREEADGDERALVEGLRETPGMGPAGAEIFLREAQAVWPEYAPHFD
                     GKALQGAERLGLPKDPKRLARLAGDAGPAVFAAALVRAALEKKVADDVLEHAG"
     tRNA            complement(6661..6733)
                     /anticodon=(pos:complement(4776112..4776114),aa:His,
                     seq:gtg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="B591_RS21135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="B591_t21270"
                     /product="tRNA-His"
     gene            complement(6661..6733)
                     /locus_tag="B591_RS21135"
                     /old_locus_tag="B591_t21270"
     misc_feature    6761..6772
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.87"
                     /tool="antismash"
     misc_feature    6762..6780
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.23"
                     /tool="antismash"
     gene            complement(6825..7427)
                     /gene="orn"
                     /locus_tag="B591_RS21140"
                     /old_locus_tag="B591_20973"
     CDS             complement(6825..7427)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0000175 - 3'-5'-RNA exonuclease activity
                     [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="orn"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948196.1"
                     /locus_tag="B591_RS21140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20973"
                     /product="oligoribonuclease"
                     /protein_id="WP_023419318.1"
                     /transl_table=11
                     /translation="MNDRMVWIDCEMTGLSLADDALIEVAALVTDSELNVLGDGVDIVI
                     RPPDEALETMPEVVRKMHTTSGLLAELAEGTTLAEAEAQVLAYVREHVKEPGKAPLCGN
                     SVGTDRNFLARDMAALEGYLHYRIVDVSSVKELARRWYPRAYFNSPDKNGNHRALADIR
                     ESIAELRYYREAIFVPQPGPDSDTAKAIAAQHVLTSE"
     gene            complement(7533..8753)
                     /locus_tag="B591_RS21145"
                     /old_locus_tag="B591_20978"
     CDS             complement(7533..8753)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948195.1"
                     /locus_tag="B591_RS21145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20978"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_023419319.1"
                     /transl_table=11
                     /translation="MSHDSTVTADLAGRKLSGRRRKEIVAVLLFSGGPIFESSIPLSVF
                     GIDRQDAGVPRYRLLVCAGEDGPLRTTGGLELTAPQGLEALARAGTVVVPTWRSITSPP
                     PAAALDALRRAHEEGARIVGLCTGAFVLAAAGLLDGRPATTHWMYAPTLAKRYPSVHVD
                     PRELFVDDGDVLTSAGTAAGIDLCLHIVRTDHGSEAAGALARRLVVPPRRAGGQERYLD
                     RSLPEEIGADPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWL
                     ITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYRARRPQ
                     QEQQRPEPVQPTQPVQVFDGPLPPQLRRTPQGVGAHHGDPGRGAPDAYLQGRAALPGQR
                     ERPLGGV"
     misc_feature    complement(8079..8081)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8950..8963)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    complement(9102..9116)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.1"
                     /tool="antismash"
     gene            complement(9201..9401)
                     /locus_tag="B591_RS21150"
     CDS             complement(9201..9401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948194.1"
                     /locus_tag="B591_RS21150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_037788038.1"
                     /transl_table=11
                     /translation="MSTAVRWAAFGCVLAPVVLVVYGASAGGVMWVAPVLAAVTGICRL
                     LLRRAERGTKGARRAAGDVPR"
     misc_feature    9372..9381
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    9725..9739
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            10136..10660
                     /locus_tag="B591_RS21155"
                     /old_locus_tag="B591_20988"
     CDS             10136..10660
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325548.1"
                     /locus_tag="B591_RS21155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20988"
                     /product="universal stress protein"
                     /protein_id="WP_037787405.1"
                     /transl_table=11
                     /translation="MAGHESFESADRKRQVADPSAQPLAAEEARQPCDPAFRHGVVVGF
                     DGSTSSERALAYAIGMARRSGSGLIIVHVANRLPTTVWAGCEPPVFVDVPDHRTEVLGL
                     ELACAEYLGDVPWILVERGGDICHELEEVGTEYEADAIVVGSSQGVVGRLFGSVAGRLA
                     RRARRPVVVIP"
     gene            complement(10692..12521)
                     /gene="glmS"
                     /locus_tag="B591_RS21160"
                     /old_locus_tag="B591_20993"
     CDS             complement(10692..12521)
                     /EC_number="2.6.1.16"
                     /GO_function="GO:0004360 - glutamine-fructose-6-phosphate
                     transaminase (isomerizing) activity [Evidence IEA]"
                     /GO_process="GO:0006040 - amino sugar metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="glmS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980526.1"
                     /locus_tag="B591_RS21160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20993"
                     /product="glutamine--fructose-6-phosphate transaminase
                     (isomerizing)"
                     /protein_id="WP_023419322.1"
                     /sec_met_domain="GATase_7 (E-value: 2.2e-13, bitscore:
                     48.7, seeds: 307, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIVGYIGRRDDVAPLLLEGLQRLEYRGYDSAGIAIHGKSGSRS
                     TGLKSVKAKGRVRDLEARVPARFKGSVGIAHTRWATHGAPNDENAHPHLDADSKVAVVH
                     NGIFDNASDLRARLTADGVVFLSETDTEVLAHLIGRSEADTLEGKVREAVGQIEGTYGV
                     AVLHADFPDRIVVARNGSPVVLGIGEKEMFVASDVAALVSHTRQVVTLDDGEMATLKAD
                     DFRTYTTEGSRTSATPTTVEYEAESWDMGGHDTYMHKEIFEQAEAVDRVLRGRIDDRFS
                     TVHLGGLNLDAREARGVRRIKILGCGTSYHAGQIGAQLIEELARIPADAEPASEFRYRN
                     PVVDPDTLYIAVSQSGETYDVLAAVQELKRKGARVLGVVNVVGSAIAREADGGLYVHAG
                     PEVCVVSTKCFTNTVVAFGLLALHLGRTRDLSVADGKRIIAGLRKLPEQIADILSREDE
                     IEKLAEEFTEARSMLFIGRVRGYPVAREASLKLKEVSYIHAEAYPASELKHGPLALIEP
                     AMPTVAIVPDDDLLEKNRAALEEIKAREGKILAVAHREQEKADHTIVVPKNEDELDPIL
                     MGIPLQLLAYHTALKLGRDIDKPRNLAKSVTVE"
     misc_feature    complement(12551..12565)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.09"
                     /tool="antismash"
     gene            complement(12612..12887)
                     /locus_tag="B591_RS21165"
                     /old_locus_tag="B591_20998"
     CDS             complement(12612..12887)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015608703.1"
                     /locus_tag="B591_RS21165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_20998"
                     /product="hypothetical protein"
                     /protein_id="WP_003948191.1"
                     /transl_table=11
                     /translation="MLERRTNHDDLVDHLVRTTPLSRGEAGRVVMDVLAYFDETTEECV
                     RRRHRELQAQGLGNTEIFERIAEELPRRAVAPPALSLRQLRRIVYG"
     misc_feature    complement(12838..12853)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 20.91"
                     /tool="antismash"
     gene            complement(13005..13913)
                     /locus_tag="B591_RS21170"
                     /old_locus_tag="B591_21003"
     CDS             complement(13005..13913)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638121.1"
                     /locus_tag="B591_RS21170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21003"
                     /product="DUF4429 domain-containing protein"
                     /protein_id="WP_023419323.1"
                     /transl_table=11
                     /translation="MAEITQRDGSWSYEDGRIRIVPGAKAHPVRQVLGEVAVPLAAVAG
                     ITFERDRKGGRLRLRLRDGACPVVRAAEGRLPEGADPYRLVVESGREDLAEYVVAEVRQ
                     ALLLEQIPEGPVERFLLPGPALPVSGGGGDGTAAFDGREVRLTWNWKGKETKTSAGPTT
                     LALADLTGVTWVPPQGLENGHLRFLTRSGGGKTVAPEHDPHALDLWGLSKKEHTAVLVA
                     AAVLVALAARGEPERTPGALDKPEEPAQLRLPSAPAPQAAPADDPDALLRRLRELGELH
                     QDGVLTDEEFSLAKQAVLRRL"
     misc_feature    13890..13903
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.65"
                     /tool="antismash"
     gene            complement(14001..15821)
                     /locus_tag="B591_RS21175"
                     /old_locus_tag="B591_21008"
     CDS             complement(14001..15821)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407742.1"
                     /locus_tag="B591_RS21175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21008"
                     /product="IucA/IucC family siderophore biosynthesis
                     protein"
                     /protein_id="WP_023419324.1"
                     /sec_met_domain="IucA_IucC (E-value: 6.6e-78, bitscore:
                     260.1, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTSPTDQLAAPTAHLTPELWAAAGRHLVRKGLAEFSHERLLTP
                     EPLPGAEPDAEGRTAHRVVTDDGVTEYRFAARLLSLDHWDIAADTITRHGEGGTELPLD
                     ALDFILDTRTALGIGDAILPVYLEEISSTLSGAAWKLAQARPSAAELARAGFQAIETGM
                     TEGHPCFVANNGRIGFDVREYHQYAPETASPVRLLWLAARRDRSTFTSGAGLDYDTLVK
                     GELDPATLARFAATLAGQGLDLADYHLLPVHPWQWWNKLSVSFAAEVAQQRLVLLGEGD
                     DAYLAQQSIRTFFNTSHPDRHYVKTAMSVLNMGFMRGLSAAYMEATPAINDWLAQLIAG
                     DEVFRAARFSIIRERAAIGYHHRQYERATDRYSPYRKMLAALWRESPVPQLGEGQRLAT
                     MASLLHTDTDGASLAGALIAESGLAPEVWLRRYLDAYLVPVLHSFYQYDLVYMPHGENV
                     ILVIEDGAVDRVIFKDIAEEICVMDPDAVLPPAVERIRAEVPEEMKILSIFTDVFDCYL
                     RFLNATLAGEGVLDEDTFWRTAAMSVRAYQESMPQLADKFAQYDMFAPTFALSCLNRLQ
                     LRDNQQMVDLADPSGALQLVGDLVNPLAGR"
     gene            complement(15818..16420)
                     /locus_tag="B591_RS21180"
                     /old_locus_tag="B591_21013"
     CDS             complement(15818..16420)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1203: putative siderophore biosynthesis protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407740.1"
                     /locus_tag="B591_RS21180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21013"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_023422750.1"
                     /transl_table=11
                     /translation="MTTPRTAKVRPDRLAIRPLDLDADAGLVHGWVTHPKSAFWLMQEL
                     SVDEVRGEYASIADHPHHDAFIGLYEDSPAFLMERYDPAHVELVGLYDPEPGDVGMHFL
                     CAPTDTPLHGFTRAVIFAVMEYLFADPDTVRVVVEPDVRNAAVHALNEAVGFEIARKIA
                     KPEKEAYLSVCTRDAFEAAKKAATVQAGDDTKEQAPR"
     gene            complement(16417..17727)
                     /locus_tag="B591_RS21185"
                     /old_locus_tag="B591_21018"
     CDS             complement(16417..17727)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080: lysine/ornithine N-monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948187.1"
                     /locus_tag="B591_RS21185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21018"
                     /product="lysine N(6)-hydroxylase/L-ornithine
                     N(5)-oxygenase family protein"
                     /protein_id="WP_023422751.1"
                     /transl_table=11
                     /translation="MSTPPERSSRTAFDSAEPLDLLGIGLGPFNLGLACLAEPLDEIDA
                     LFLETKPDFDWHSGMFLDGAHLQTPFMSDLVTLADPTSPYSFLNYLKESGRLYSFYIRE
                     NFYPLRTEYNDYCRWAAARLGSVRFSTTVTEVTYDDQSALYTVTTDRGDTYRARHLALG
                     TGTPPHIPEPCRDLGGDLLHNSRYLEHKAALQAKKSITLVGSGQSAAEIYHDLLAEIDV
                     HGYQLNWVTRSPRFFPLEYTKLTLEMTSPEYIDYFHALPEDTRYGLEQKQKNLFKGIDG
                     ELINAIFDLLYEKNVRGPVPTRLLTNTALRTATWDESEGTYTLGLRQEEQGKDFDLTSE
                     GLVLATGYQYRVPDFLEPVRDRIRWDGRGRFDIARNYSIDTTGRGIFVQNAGVHSHALT
                     SPDLGMGAYRNSVILRELLGTAPYAVEKSIAFQEFSV"
     gene            complement(17711..19168)
                     /locus_tag="B591_RS21190"
                     /old_locus_tag="B591_21023"
     CDS             complement(17711..19168)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894987.1"
                     /locus_tag="B591_RS21190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21023"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_023419327.1"
                     /transl_table=11
                     /translation="MSLLAPRSHLLNDLNVEAYRRSVTEGVERVAASLTGATSPFTGVT
                     PAALAPVVDAVDLDRPLGDTAAALDELTDVYLRDAVYFHHPRYLAHLNCPVVIPAVLGE
                     AVLSAVNSSLDTWDQSAGGTLIERRLIDWTAGRIGLGEGADGVFTSGGSQSNLQAMLLA
                     REEAKAAHPTQLRVFTSDVSHFSVRKSATLLGLGPDAVVTIPTDRERRMRIEVLAAELR
                     RCEAEGLVPMAVVGTAGTTDFGSIDPLPEIAELCARHNTWMHVDAAYGCGLLVSPTRRG
                     LLTGIEHADSVTVDYHKSFFQPVSSSALLVRDGATLRHATYHADYLNPRRAAEERIPNQ
                     VDKSLQTTRRFDALKLWMTLRVMGADGVGQLFDEVCDLAGEGWELLVADPRYDVVVEPS
                     LSTLVFRYLPGQPTDPAQIDRANLYARKALFASGDAVVAGTKVDGRHYLKFTLLNPETK
                     ASDIAAVLDLIAGHAEQYLGESLVHAS"
     misc_feature    19214..19228
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.78"
                     /tool="antismash"
     misc_feature    complement(19236..19254)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 36.53"
                     /tool="antismash"
     gene            complement(19502..20368)
                     /locus_tag="B591_RS21195"
                     /old_locus_tag="B591_21028"
     CDS             complement(19502..20368)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /GO_process="GO:0055072 - obsolete iron ion homeostasis
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1200: vibriobactin
                     utilization protein ViuB"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468230.1"
                     /locus_tag="B591_RS21195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21028"
                     /product="siderophore-interacting protein"
                     /protein_id="WP_023422752.1"
                     /transl_table=11
                     /translation="MTTTPTAPARTPFRFFDVEVRGSRRLSPSLVRLTFGGEELALFES
                     GGRDQSCSLFLPHPGQRVPRVPVEAGENWWAAYRAMPEEERAVMRSYTVRAQRRADDGT
                     TEFDVDFALHGDSGPACRWAARALPGDRIVVLGPSVTENVSVRFRPPGSAAWALMWADL
                     TSLPATEAILEWLPAGFPVRLWIEVPHAEDRRELATAADAEITWLVADEGAPSAAEAVR
                     AAELPTGEPYVWIAGEAGRMRTLRRHLVGERGFDRRAVTFVGYWREGASEEQLRAESLA
                     TGERRTA"
     misc_feature    complement(20402..20420)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: strong, score: 31.62"
                     /tool="antismash"
     gene            complement(20467..21093)
                     /locus_tag="B591_RS21200"
                     /old_locus_tag="B591_21033"
     CDS             complement(20467..21093)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008407728.1"
                     /locus_tag="B591_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21033"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_023422753.1"
                     /transl_table=11
                     /translation="MTAEKDGRRVGRPPLTERRKAATRLEIAREAVRLFAAQGVAATTA
                     DEIAAAAGISPRTLWRYCSSKEECVGPLLTTALDAAAERLTSWPRERTLTDGISAYPPG
                     RSATALAEDEQALRDLVRLVRAEPGLRAVWLQVHHAAEPVLARVFAARTGLSPDALEPR
                     VQAALLNTALRVAVEEWAWNTAPGTGTPGEAITEVLAIAEAGLPR"
     gene            21251..22018
                     /locus_tag="B591_RS21205"
                     /old_locus_tag="B591_21038"
     CDS             21251..22018
                     /EC_number="1.1.1.-"
                     /NRPS_PKS="Domain: PKS_KR (11-177). E-value: 1.9e-09.
                     Score: 29.6. Matches aSDomain:
                     nrpspksdomains_B591_RS21205_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948181.1"
                     /locus_tag="B591_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21038"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_023422754.1"
                     /sec_met_domain="adh_short (E-value: 6.3e-35, bitscore:
                     119.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTTTGLAGRAVVVTGAGSGIGRAAALRFAGEGAKVLLADLNGEA
                     AEAAAREITEAGGTAVTVAGDLGDQTVVDQVVATAVERFGSLDVLVNNAGIMDRMSAAG
                     ETDDAEWERVVRVNLTAPFLLTRAALPHLLATGRGAIVFTASEASLRGSAAGAAYTASK
                     HGVAGLTKSVAVMYREKGLRANAIAPGGTATNIQVDADREAHGPAVLGSYMRNVGSPAQ
                     AEEQAAAIVFLASDAASNINGVILPVDGGWAAV"
     CDS_motif       21284..21361
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B591_RS21205_0001"
                     /evalue="4.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="B591_RS21205"
                     /protein_end="37"
                     /protein_start="11"
                     /score="9.6"
                     /tool="antismash"
                     /translation="VVVTGAGSGIGRAAALRFAGEGAKVL"
     aSDomain        21284..21781
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS21205_PKS_KR.1"
                     /evalue="1.90E-09"
                     /label="B591_RS21205_PKS_KR.1"
                     /locus_tag="B591_RS21205"
                     /protein_end="177"
                     /protein_start="11"
                     /score="29.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVTGAGSGIGRAAALRFAGEGAKVLLADLNGEAAEAAAREITEA
                     GGTAVTVAGDLGDQTVVDQVVATAVERFGSLDVLVNNAGIMDRMSAAGETDDAEWERVV
                     RVNLTAPFLLTRAALPHLLATGRGAIVFTASEASLRGSAAGAAYTASKHGVAGLTKSVA
                     VMY"
     gene            22105..22542
                     /locus_tag="B591_RS21210"
                     /old_locus_tag="B591_21043"
     CDS             22105..22542
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317341.1"
                     /locus_tag="B591_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21043"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_023422755.1"
                     /transl_table=11
                     /translation="MNQDEEQIRRLIEEWASAVHRGDLATVVRDHADDLVMYDVPPPYE
                     GVRGLDAYRAVWPAFFAWQASGAEFALDTLDVTAGQDVAYAHALLCCGTPEELAERPAL
                     RLRLTLGLRKEDGRWVVAHEHHSFPDLSSASEPPSPQHSSS"
     gene            complement(22479..22754)
                     /locus_tag="B591_RS21215"
                     /old_locus_tag="B591_21048"
     CDS             complement(22479..22754)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010638100.1"
                     /locus_tag="B591_RS21215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21048"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_023419332.1"
                     /transl_table=11
                     /translation="MPPEDDGHAIQVHLDRLLEARSMTLAELAARVGVTNVNLSVLKNG
                     RAKAIRFTTLTAICRVLECQPGDLLSYEEECWGEGGSDAEERSGNE"
     gene            complement(22754..23374)
                     /locus_tag="B591_RS21220"
                     /old_locus_tag="B591_21053"
     CDS             complement(22754..23374)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894981.1"
                     /locus_tag="B591_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21053"
                     /product="DUF2975 domain-containing protein"
                     /protein_id="WP_023422756.1"
                     /transl_table=11
                     /translation="MPEDRKMLEPLTSVVSVTLRILLGLFVAGFLLSLFVDGVHWGRGD
                     LCVTVDWASTSGGDFHPFEPLPGAGVGYTPRFCAEEPTTWQQVLGVVRTAPLTVMLIGG
                     LYLLDRLLRLAVREGVHTRGAAARLRVLGWWLLLGSLVVETAEAVAGGALLNTLTDDEV
                     AGAAWTQLWSAPFLAVLTGLGLLTFARIVGASADLRDELDAVV"
     misc_feature    23392..23406
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     misc_feature    23395..23411
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.67"
                     /tool="antismash"
     gene            23607..24167
                     /locus_tag="B591_RS21225"
                     /old_locus_tag="B591_21058"
     CDS             23607..24167
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894980.1"
                     /locus_tag="B591_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21058"
                     /product="DUF3093 family protein"
                     /protein_id="WP_023422757.1"
                     /transl_table=11
                     /translation="MDQRGQAIPSVDRTVTYREDPPRTWTRICLAAYVLWAVYQAFQLL
                     PDELTAWLVVCAMSLLLLLCLLAVPLSKRLYHRIRLADGELRVGRERLPVASLTPVSLA
                     AAADEPGRAGLRAYRASLTPDQLKEARRRTNALTRPRLVGGAWAVPVGMEELVVETAEG
                     ASLVIATRDRAGLLGALTRARGI"
     gene            complement(24910..26085)
                     /locus_tag="B591_RS21230"
                     /old_locus_tag="B591_21063"
     CDS             complement(24910..26085)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507859.1"
                     /locus_tag="B591_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21063"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_023419335.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.1e-37, bitscore:
                     127.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.9e-21, bitscore:
                     74.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-47, bitscore:
                     160.5, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDHRLSAEHEELRRTVEAFAHDVVAPKIGDLYERHEFPYEIVR
                     EMGRMGLFGLPFPEEYGGMGGDYLALGIALEELARVDSSVAITLEAGVSLGAMPIHLFG
                     TEEQKRAWLPRLCSGEILGAFGLTEPGAGSDAGGTRTTARLDEATNEWVINGGKCFITN
                     SGTDITGLVTVTAVTGRKPDGSPLISAIIVPSGTPGFTVAAPYSKVGWNASDTRELSFD
                     DVRVPAANLLGEQGRGYAQFLRILDEGRIAIAALGTGLAQGCVDESVKYAAERHAFGKP
                     IGSNQAIQFKIADMDTRAYTARLAWRDAASRLVAGEPFKKQAAAAKLHSSTVAVDNARD
                     ATQIHGGYGFMNEYPVARMWRDSKILEIGEGTSEVQRMLIARELGVGGGRG"
     gene            complement(26145..27122)
                     /locus_tag="B591_RS21235"
                     /old_locus_tag="B591_21068"
     CDS             complement(26145..27122)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003948168.1"
                     /locus_tag="B591_RS21235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21068"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_023422758.1"
                     /sec_met_domain="HMGL-like (E-value: 7.8e-47, bitscore:
                     158.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTESPAPATGPGVPGLPMVVRADGLPSRVRIHEVGPRDGLQNEKT
                     VVPTDVKAEFVRRLAAAGLTTVEATSFVRPEWVPQLADAEQLFPMLDEVREAGTDLPVL
                     VPNARGLDRALALGARHVAVFASATETFARRNLNRTVAESLAMFEPVVTRAKAEGLRVR
                     GYLSMCFGDPWEGPVPEAQVVRAAAALHAMGCDELSLGDTIGVATPGQVGSLLRALHAA
                     GVEPGALAVHFHDTYGQALSNTLAALQHGVTVVDASAGGLGGCPYARSATGNLATEDLV
                     WMLHGLGIDTGTDLGALVATSDWLAARLGRPSPSRTVRALSHQE"
     gene            complement(27119..29146)
                     /locus_tag="B591_RS21240"
                     /old_locus_tag="B591_21073"
     CDS             complement(27119..29146)
                     /EC_number="6.4.1.2"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468214.1"
                     /locus_tag="B591_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_21073"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_023422759.1"
                     /sec_met_domain="ATP-grasp (E-value: 3e-07, bitscore: 28.6,
                     seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 7e-09, bitscore:
                     33.9, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFDTVLVANRGEIAVRVIRTLRELGVRSVAVYSDADTDARHVREA
                     DAAVRIGPAAAAESYLHIPRLLEAARRTGAQAVHPGYGFLAENAAFARACAEEGLVFIG
                     PPADAIALMGDKIRAKETVRAAGVPVVPGSSGSGLTDAELAAAAREIGMPVLLKPSAGG
                     GGKGMRLVREEAALAEEIAAARREARASFGDDTLLVERWIDRPRHIEIQVLADGHGDVV
                     HLGERECSLQRRHQKIVEEAPSVLLDEATRAAMGEAAVQAARSCGYTGAGTVEFIVPGD
                     DPAGYCFMEMNTRLQVEHPVTELITGVDLVEWQLRVAAGEPLPFAQDDITLTGHAVEAR
                     LCAEDPARGFLPSGGTVLALAEPTGPGIRTDSGLSEGTEVTSVYDPMLAKVIAYGPDRP
                     TALRRLRAALAGTVTLGVPTNAGFLRRLLAHPDVVAGALDTGLVAREADALADPGVPPE
                     VYEAAAAVRLAALAPVPDARGWSDPFAAADGWRLAGPPAPVVHHLRVHGQETVAYTAEA
                     PGTHRLTEDSVDVTLDGVRHSFRRAGQWLAREGDAWQVTDVDPVAEALAGADRAAGAKA
                     LTAPMPGTVTLVKVAVGEEVEEGQGLLVVEAMKMEHLICAPHAGTVTELDVSPGTTVAM
                     DQVLAVVTPPEAPEVPSEEAPAETAVVRQAPAAPAEEAQA"
ORIGIN
        1 acccgggacc aggagacgga gaagcggtac gtgccgaggc cgagacgggc catgagcgcc
       61 acgtcctcgg cgctgcggtg gtagtggtcg acggcgacgt caccggtgtc accgttctcc
      121 gtcttgcccg gggtgtggct gaaggtgtcc cagatggacg gggtccggcc gtcctcggcc
      181 gcggccccct cgatctggta cgaggcggtc gccgcgcccc agaggaagtc ggtggggaat
      241 ctgccctgcc gggccagggc ggccgcctcc ccgggcgcct ccccggtggc gggtgtggcg
      301 gaggtggctg cggtggggac tgtggtcaag acgtactccc gttctcgctt gggatgaggg
      361 aagggcgggg cgggcggcgg gtggtcgggc ccgccgcccg ggcgtgtcct cgaagggctg
      421 ctcagccctt caccgcgccc tgcatgatgc cgccgacgat ctgcttgccg aagaccacga
      481 aggcgatcag cagcggcagc gtgcccagca gcgcgccggc catgatcacc gactggtcgg
      541 ggatgtagcc ccggccgagg ccggtgaggg ccacctgcac ggtggggctg ccgttctggg
      601 tcagcgcgat gatcggccag aagaagtcgt tccaggactg cacgaaggtc agcatcccga
      661 gcaccgccat cgccggccgg gccgcgggga agaccacgtg ccacaggacc cgcaggctgt
      721 tggcgccgtc gacccgggcc gcctcgatga tctcggtggg cagcgcctgg agcaggtact
      781 gccgcatgaa gaagacaccg aaggcggtga ccagggtcgg caggatgacc gcctggagct
      841 ggtcggacca ggagagcttg gccaccatca tgtacagcgg tacgacgctg agctggggcg
      901 gcaccatcat cgtgccgatc accagcagca gcagcgcgtt cttgaaccgg aaccgcagct
      961 tggcgaaggc gaagccggcc agggtcgaga agagcaccgt gccgaccgag accgtgccgg
     1021 ccaccaccac ggtgttcagc agggccgacc ccatgttggc gtcggtccag gcgatctcca
     1081 ggttcttgaa gaggttcccg ccgaaccaga agggcggcgg ggtctcggcc agccgcgtgt
     1141 tgttccgcga ggccgcgatg gccgtccaga ccagcgggaa gagcgagatg acggtgacca
     1201 cgccgagcac ggcgtacgtg atccggccgc cgtgcagctg gcgcccggcc ccgctgcggc
     1261 gcgggcgccg ggaccgcttc tcgggcggcg tggcgagggg gcggggagcg gagtcctcgc
     1321 gcgcgggcga tggtgcgatg ctcatgcttt cccctcgcct cggcgcagcc accgggtgac
     1381 cgcgagagag accagcccga tcacgatcag cagcaggaac atggcccagg cgatggcgga
     1441 cgcccggccc aggtgcaggt tggtccagcc ctgctcgtac aggtacaggc cgagggtctg
     1501 gaactggtgg tcggagccgc ccgtcgcccc gccgccgccg ttgaacagca gcggctcgcc
     1561 gaagagctgg atggcgccga tggtcgagac gaccacggtg aacaggatgg tcgggcgcag
     1621 cgagggcagc gtcacgtgca ggaactgctg ccagcgcgag gcgccgtcca gcgccgccga
     1681 ctcgtagagg tcggagggga tggactgcat cgcggccagg tagatcagcg cgttgtagcc
     1741 ggtccagcgc cacacgacga tggaggagac ggccagctgc gaggtgaagc tgccgttctg
     1801 ccagtcgatg tgctcgaaac cgagcagcga gaggacccag ttgatcatcc cgtagtcgcg
     1861 tccgaagagc atgacgaaga ccagggtcgc cgccgccacc gaggtggcgt acggggtgag
     1921 cgccgccacc cggaagaaca tcgagccgcg cagccggtag ttgagcagat gggcgatgcc
     1981 caaagccatc agcagctgcg gcaccgtgga gaggatgccg atggtgaagg tgttctggag
     2041 cgcgttccag aagaagtcgt cgtcgagcag gcgcgtgtag ttgcgcagcc cgatccattc
     2101 catgtcgttg ggggccgtca gctccacccg gtggagcgag gcccacccgg tgtagagcag
     2161 cgggaagagg ccgaaggccg cgaagaagag gaagaacggc gcgatgaacg cgtacggact
     2221 ccacttcacg tcccgccggt accagcggga gcgccgctcg cgccgccgcc ggtcggccgc
     2281 cttcctgccg gggtcctggg gcggccgcga ggccaccgcc accccgctcg cgtgggccgc
     2341 cgcgccctcc tccaccgagg agggcgcggc cgccgggaat tcactcgcca tcgcgggtca
     2401 ctggtccagt gcgttgtcga tcgccttgac cgcggccttc cagccctcct cggaggactt
     2461 gcccttctgg tcgacctgga gcatgccgac gtcggccagg ttctgcgcga tcaccaggtc
     2521 cttcgggccg aggatctgca ccggggcgcc ctcggcggcc tgcgccagga tcttgccgat
     2581 cggggcgtcg tcgaagtact cgtgcttggc gtcggcgatc tccggcaggt cgtaggcggc
     2641 ctgcgcgctc gggaaggaac cgcgctcggc gaagaacttg gcctgctgct cgggggcggt
     2701 cagccaggcg gcgagcttgg cggcctcctc cttgttcttg cccgcggagg gcaccgtcag
     2761 gaaggcgccg ccccagttgc cgggcttcgg cgcctgggcg atgtcccact tgtcggcgtt
     2821 cttctcgccg cccttgtcct ggatgtagcc gagcatccac gcggggcagg agaccgtggc
     2881 gaaggagccg ttggagaagc cctggttcca gctgggcgtg aactgctgga gcttggcggt
     2941 cagcccctcg gtggcgaact cggccgccag gtcccaggct tccttcaccg ccgggttcga
     3001 cttgtagacg acctcaccct tgtcgtcgta gtagcggatc gcgctgctgc cggtcaccgc
     3061 cgccatcacg ccgggcgcgc cgtcgacgaa cttggcgccc ttgggagcgt tcttctggaa
     3121 ctccttgccg gcctccaggt acttgcccca gtcacccgcc cacaacttgc cgacctcctc
     3181 gcggtcggtc ggcaggcccg ccttctcgaa gaggtccttg cggtagcaga tggcctgcgg
     3241 cccgatgtcc gtgccgagcg ccaccgtctt gccggccttg gtggtgccct ggtcccactt
     3301 ccacttcagg aaggcgtcct tgtcggcgcc gggggccttg gagaggtcct ccagcttgtc
     3361 gccctgggtc tggacgacct cggcgatgtt gttgacctcg acggcctgga tgtcggcgag
     3421 accgctgccg gtgcccaggt gggtgaggag ctgcgggtag tagttctcgt tccgctcgat
     3481 ggacgtctgc ttgatgacga cgtccttgtt ctccttcatg tactgctcgt agagtccggc
     3541 ctccttgagg ccgaacgcac cgaagacccc gacggtcagc gtggtcttcc ccttgtccga
     3601 cccggcttcg ctcccggcgg cctcgggctc gtcgtccgac gcgcagcccg cgagcaggct
     3661 ggtccccagg gcggcgacgg ccgccaggac caccgccttg cgggccgtac ggcttctcgt
     3721 acgcatggtc tcctcctgac gccggtccgg tcccggcccg tcaaccccct tgcgggcggc
     3781 tgaagtcggc tcctccgggt cgaaccaggg aatgtacggg tgttggagtg gcagctaggg
     3841 tgggagcgct cccacccgtg atgtcgtgaa gagtcgcggc tgcgggcagg agtgtcaaga
     3901 caccggacgc cgccaggtcc ggtcggttat cgggctgtta cggtctcctc cgatcctggg
     3961 gcacgacacg ggcgcgtgcc catcactggg aggcaacgga tgacggctgg tcggagcaac
     4021 gggcgcagcg ggggccgccc caccctcgaa gaggtcgccg cccgcgccgg ggtcggccgc
     4081 ggcacggtct cccgcgtcat caacggctcc ccccgcgtca gcgagaccac ccgcgccgcc
     4141 gtcgaggccg ccgtggcgga actgggttac gtcccgaaca ccgccgcccg cgcgctggcc
     4201 gccaaccgca ccgacgccat cgccctggtc gtccccgaac ccgagacccg cttcttcacc
     4261 gagccgtact tctccgacat cctcagcggc atcggcgccg ccctcgcccc gaccgacctc
     4321 cagctcctcc tcaccttcgc cgacggcgcc cgcgaacgcc gccgcctcgc ccagtacctc
     4381 gccgcccacc gcgtggacgg cgtcctgctg gtctccgtcc acgaggacga tccgctgccc
     4441 gacctcctct cccagctgga gatccccgcc gtcatcagcg gccgccgcag cgagaacgag
     4501 ccgctggcct ccgtcgacac cgacaactac tccggcgccc gcgccgccgt cacccacctc
     4561 cttgagcggg gccgcaccac catcgccacc atcagcggcc gcctcgacgt ctacggtgcc
     4621 cagcgccgac tcgacggcta ccgctccgcc ctcggtgacg ccggccgccc ccccgaggac
     4681 agcctggtcg ccgccggcga cttcaccgag gagggcggcc gccaggccat gcgcctcctc
     4741 ctggaccgcc gtccggagct cgacgccgtc ttcgcctgct ccgacgtgat ggccgccggt
     4801 gcccgccagg tgctccgcga ggccggccgc cgcatccccg aggacgtggc cctggtcggc
     4861 ttcgacgact ccgccgtcgc ccgcctgatg gaccctccgc tcacctccgt ccgccagccc
     4921 accgccgcca tgggccgcgc catgaccgaa gcgctcctcg ccgagatcgc cgagggcagg
     4981 ccggacagct cccggctgcg cagaccccgg caggtcgtcc tggacacgga gttggtggtg
     5041 cgggcctcgt cctgagccgg tcgcgggccg gcgggcggtg cgccgggggc gcgcggccga
     5101 gcctcccgcc cccggcgcga ggtggtgcgg gcctcgtcct gagccggtcg cgggccggcg
     5161 ggcggtgcgc cgggggcgcg cggccgagcc tcccgccccc ggcgcgcccc tcgccgtacc
     5221 atccctcggg tggaactccc cgactacctg atcagacttc agcgcgcggc cgacgacgag
     5281 gggcgccggc tcgaacacct cgacgaggac gagcgggacg cggcgcggcg cctctacttc
     5341 aacgccgcag ccgaggtcga cgtggccgta cgcgacttcg ccgccaccgc cgggctcgac
     5401 cgccacaccg tggagaagga agtgcggcag cgggcccgcc agccccccgc ggagtgagcg
     5461 cggcccgttg tcgtaccccc gaagtacggt cggctccatg aacacccgta cggacaccgc
     5521 gccccgcccc gccgccgtgg tcaacaccga gatccgcgcc ctgctcatgc gccgcggcgg
     5581 cctggctccc gccgagcgcg cggcgtacga gcggctgctc gtggagtggg cccaggcggt
     5641 ccgcgccgag gtggtcgtcg cggcctgatc cttccgcgac ggccgcgccc catctcgtca
     5701 tgatcgacaa cggccgccgt cggcacctgc tctgcgcccg ctgcgggatc agcctccgcg
     5761 ccgacgaggt gaccgccccc gacccggcgc tcctgcgcgc ccgtgccgac cgctggcgac
     5821 aggtgtggcg ccgtacggtc tgagaggtgc ggcggggctc agcccgcgtg ctccaggacg
     5881 tcgtcggcga ccttcttctc cagggcggcc cggaccagcg cggcggcgaa gacggccggg
     5941 cccgcgtccc cggcgaggcg ggccaggcgc ttcgggtcct tgggtaggcc gagccgttcg
     6001 gcgccctgga gggccttgcc gtcgaagtgg ggcgcgtact cgggccagac cgcctgggcc
     6061 tcgcggagga agatctcggc gcccgcagga cccatgcccg gcgtctcccg cagcccctcg
     6121 acgagcgccc gctcgtcccc gtcggcctcc tcgcggatcc gccgcaggtc accccggtgc
     6181 tcctccagca gccgttccgc accctccccg agctgggtcg cggtccgctc gtcgtaccgc
     6241 cggtaaccgc cctcgccgag tgcgtccacc cgctcctgcc agctcgcgtc ggccatggca
     6301 cgcgggttgc gcatcccgtc atggaacagg gcgccggcgg cggccaccgc gacggaggcc
     6361 cggatgcggg cactgagcag ggaactgagg acgagcaact ggtagagcgg ctgcggggtg
     6421 tccttgaggg tgatccccgc ctcgcgcgcg taggtggtgc cgtgccggtc gaggagagtg
     6481 gcggcgacgg cggactgcga agcactcacg tccggtctcc cttcgtacga ggcgtacgtg
     6541 tgcctggagg cgtgcctgct ctccactgtg gcccggatcg ggcggggccg cgcggggagc
     6601 gacctgcgaa aacgccaaga accccgtcct gatctctcag gacggggctc ttgaccacag
     6661 ggtgagtgac gggacttgaa cccgcggcca cctggaccac aaccaggtgc tctaccaact
     6721 gagctacacc caccgcgtcc ggtcgtttcc gaccggccga gaaaaagtgt acagggtccg
     6781 agggggtgct cgcgcacacc ttttcccggg ggccgcgtgg ggccttattc ggaggtcagc
     6841 acgtgctggg cggcgatcgc cttcgcggtg tcggagtcgg gcccgggctg cggcacgaag
     6901 atcgcctcgc ggtagtagcg cagctcggcg atggactcgc ggatgtcggc gagggcgcgg
     6961 tggttgccgt tcttgtcggg gctgttgaag taggcccgcg ggtaccaccg gcgtgccagc
     7021 tccttcaccg aggagacgtc cacgatgcgg tagtggaggt acccctccag cgccgccatg
     7081 tcccgcgcga ggaagttccg gtcggtgccg accgagttcc cgcacagcgg agccttgccg
     7141 ggctccttga cgtgctcacg gacgtacgcg agaacctgcg cctccgcttc ggccagcgtg
     7201 gtgccctccg ccagctcggc gaggagcccg gaggtggtgt gcatcttgcg caccacctcg
     7261 ggcatggtct ccagcgcctc gtccggcgga cggatcacga tgtccacgcc gtcgccgagc
     7321 acgttcagtt ccgagtcggt gaccagcgcg gccacctcga tgagtgcgtc gtccgccagc
     7381 gagagcccgg tcatctcgca gtcgatccac accatgcggt cgttcatacg gttcagccta
     7441 ggccctgtcc gcgaaaacct gtccggcccg tgcggggtcc ggcacgcacc cggaagtgcg
     7501 ggccggaccc cgcgggccgg acctgtcctc tctcagacgc cgcccagggg acgctcccgc
     7561 tggcccggaa gtgccgcgcg cccctggagg taggcgtccg gtgctccccg gcccgggtcc
     7621 ccgtggtggg cgccgactcc ctgcggcgtc cggcgcagct gcggcgggag cggcccgtcg
     7681 aagacctgca ccggctgcgt gggctgcacc ggctcaggcc gctgctgctc ctgctgcgga
     7741 cggcgggccc ggtaggcggc gcggtacgcg gcgggggagg agccgagctg gcggcggaag
     7801 tgcccgcgca gtgcgaccgg cgaccggaag ccgcagcggc cggcgacctc gtccaccgag
     7861 tagtcggagg tctccagcag ccgctgcgcc tgcagcacgc gctgggtgat gagccactgg
     7921 agcggggcgc tgccggtcag cgaacggaag cgccggtcga aggtccggcg gctcatgtac
     7981 gcgcgcgcgg ccagcgtctc cacgtcgaac tgttcgtgga ggtgttccag cgcccaggcg
     8041 acgacctcgg ccagcgggtc ggcgccgatc tcctccggta aagacctgtc gaggtagcgc
     8101 tcctgcccgc cggcccggcg cggcggcacg accaggcggc gcgccagggc gcccgcggcc
     8161 tcgctgccgt gatcggtccg gacgatgtgc aggcagaggt cgatcccggc ggcggtgccc
     8221 gccgaggtga gcacgtcccc gtcgtcgacg aagagctccc gcgggtcgac gtggaccgag
     8281 gggtagcgct tggccagcgt cggcgcgtac atccagtgcg tggtggccgg cctgccgtcg
     8341 agcagcccgg cggcggccag gacgaacgcg ccggtgcaca gaccgacgat gcgcgcgccc
     8401 tcctcgtgcg cccggcgcag cgcgtccagc gcggcggcgg gcgggggtga ggtgatggac
     8461 cgccaggtgg gcaccaccac cgtccctgcc cgggcgaggg cctccaggcc ctgaggtgcc
     8521 gtcagttcca gtccgccggt ggtccgtagc ggtccgtcct cgccggcgca gaccagcagc
     8581 cggtagcgcg gcacgcccgc gtcctggcgg tcgatgccga agacggagag cgggatggaa
     8641 ctctcgaaga tgggaccgcc gctgaagagg agaaccgcga cgatctcctt gcggcgccgc
     8701 ccggagagtt tgcggcccgc gaggtccgcc gtgacggtgg agtcgtggct catgtggcta
     8761 agcccccctc ggtggccgtg tcactccagt cctgtcggat ctgtcgctcc tgcacgtttc
     8821 ccctcggtcc tgcgcgtgtc ccccgccata agacagtcat gatcgaatct actgtgtccc
     8881 gtggtgccac cgtgaccagt tgagcagacg ccggaatgtc gacaaggcaa cgtggcgtaa
     8941 agcattcgat cacgaagcgt cgcactcccg ggctcgactg ggaagtgcgt ctgcggcggg
     9001 tggccggtcc ccgtagggtg cgaacgcctc gttcggtcct gtcctcgcag gttgtgccgg
     9061 gcgtgacggg ggttcaccca ccctggtgca acggttcgtc aacttggctg aaaacatgcg
     9121 ggcgcgtgcg tgcgaaccgg tcagctctcc ggtgtacgga aagtgcgccc cctgaccgcc
     9181 cccgtgcgcc cctctccccc ctacctggga acgtctcccg ccgcgcgccg ggcgcccttc
     9241 gttccccgct ccgcccggcg caacagcagc cggcagatcc cggtcaccgc ggccagtacc
     9301 ggcgccaccc acatcacccc acccgccgac gccccgtaga ccaccaggac caccggggcg
     9361 aggacgcagc cgaaggcggc ccagcgcacc gcggtgctca ccggggccgg accggcgtgc
     9421 cgcgccgccg tggaggccgc gggcgcgcag gccgcgccgg gtgtggtgcg ggccccgggg
     9481 aggccgcgag ggggcctggc acccgcgcag gcggttccgg gtgcccgcga gccgcgttcc
     9541 ggcgggcggg cggacgcggg gcgggggagg agggcggcgg ggtccgggac ggagacgtga
     9601 gggacgggca cgaggggctc ccagggtggg cgggtacgcc ggttcaacgc tccgcccgcg
     9661 accgggtcac ttcggggtcg cgcgggctgg gccgacccgg ggaccccgtg tcccccgggc
     9721 ggcggggccg tccggccgtt gcgatcgggg cgccgctcgg gcatgctccg tccagcgcgc
     9781 cgcccggcgg tggcgtccgg gcgggcctca ccaggccggt tcgggtccct ccgggagctt
     9841 tcgccgggcg gtgcgcgccg gtccgcgaga actgcgcatg ggggagccct cttctgggta
     9901 cgggcggtgc aaggtccgaa tacgggagaa gtggcgccgt acccttgggg cgagtggttg
     9961 ggaagatgct tcccggacac agcgggccgg tcccaccggc cggtcgtcgc ccctccggtc
    10021 gccgtcggca ccgccgttcg acccccggac ccggggttcc ccccggagcc gtgctcattc
    10081 cgtcagccgt ccccttccca cgagtccccc aaggaccttt cccgccgaga caccgatggc
    10141 cggtcacgaa tcctttgaat cagcggaccg caagcggcag gtggccgatc cctcggccca
    10201 gcccctggcg gcggaagaag cacgtcagcc ctgcgatccg gccttccggc acggcgtcgt
    10261 cgtcggcttc gacggctcga cctccagcga gcgcgccctc gcctacgcga tcggcatggc
    10321 ccgccgctcg ggctcgggcc tgatcatcgt ccacgtggcc aaccggctgc ccaccaccgt
    10381 gtgggccggc tgcgagccac ccgtcttcgt cgacgtgccc gaccaccgca ccgaggtgct
    10441 ggggctcgaa ctggcctgcg ccgagtacct cggggacgtc ccgtggatcc tggtcgagcg
    10501 cggcggcgac atctgccacg agctggagga ggtcggcacc gagtacgagg ccgacgccat
    10561 cgtggtcggc tccagccagg gcgtcgtggg gaggctcttc ggctcggtcg ccgggcggct
    10621 ggcccggcgg gcgcgcagac cggtggtcgt catcccctga gccggggtgg cccaggggac
    10681 gacggttccg gctactcgac ggtgacggac ttcgccaggt tgcgcggctt gtcgatgtcg
    10741 cggccgagct tcagcgcggt gtggtacgcc agcagctgga gcgggatgcc catgaggatc
    10801 gggtccagct cgtcctcgtt cttcggcacc acgatggtgt ggtcggcctt ctcctgctcg
    10861 cggtgggcga cggcgaggat cttgccctca cgcgccttga tctcctccag cgccgcccgg
    10921 ttcttctcca gcaggtcgtc gtcggggacg atcgccacgg tcggcatggc cggctcgatc
    10981 agcgccagcg ggccgtgctt cagctcggag gccgggtacg cctcggcgtg gatgtacgag
    11041 acctccttga gcttcagcga ggcctcgcgg gccaccggat agccccgcac gcggccgatg
    11101 aagagcatcg agcgggcctc ggtgaactcc tcggccagct tctcgatctc gtcctcgcgg
    11161 gagaggatgt cggcgatctg ctcgggcagc ttgcgcaggc ccgcgatgat ccgcttgccg
    11221 tcggccaccg acaggtcgcg ggtgcggccc aggtgcagcg cgagcaggcc gaaggcgacc
    11281 acggtgttgg tgaagcactt ggtggagacc acgcacacct cgggcccggc gtgcacgtac
    11341 agcccgccgt cggcctcgcg ggcgatggcc gagccgacca cgttgaccac gccgaggacg
    11401 cgtgcgccct tgcgcttcag ctcctgcacg gcggcgagca cgtcgtaggt ctcgccggac
    11461 tgggagacgg cgatgtagag cgtgtccggg tcgaccaccg ggttgcggta gcggaactcg
    11521 gaggccggct cggcgtcggc ggggatacgg gccagttctt cgatgagctg ggcgccgatc
    11581 tggccggcgt ggtacgaggt gccgcagccg aggatcttga tccggcggac cccgcgcgcc
    11641 tcacgggcgt cgaggttgag gccgccgagg tgcacggtgg agaaccggtc gtcgatccgg
    11701 ccgcgcagca cccggtcgac cgcctcggcc tgctcgaaga tctccttgtg catgtacgtg
    11761 tcgtggccgc ccatgtccca ggactcggcc tcgtactcca ccgtggtggg cgtggcggag
    11821 gtgcgcgagc cctcggtggt gtaggtgcgg aagtcgtcgg ccttcagggt ggccatctcg
    11881 ccgtcgtcca gggtgacgac ctggcgggtg tgggagacca gggcggcgac gtcggaggcg
    11941 acgaacatct ccttctcgcc gatgccgagg acgaccgggg agccgttgcg ggcgacgacg
    12001 atccggtccg ggaagtcggc gtgcagcacg gcgacgccgt aggtgccctc gatctggccg
    12061 acggcctcgc ggaccttgcc ctccagggtg tcggcctcgg agcggccgat gaggtgggcg
    12121 aggacctcgg tgtcggtctc ggagaggaag accacgccgt cggcggtgag ccgggcgcgc
    12181 aggtctgagg cgttgtcgaa gatgccgttg tggacgacgg cgaccttgga gtcggcgtcc
    12241 aggtgcgggt gggcgttctc gtcgttgggg gcgccgtggg tggcccagcg ggtgtgcgcg
    12301 atgcccacgc tgcccttgaa gcgggccggg accctggcct ccaggtcgcg gacgcggccc
    12361 ttggccttga ccgacttcag cccggtcgac ctggagcccg acttgccgtg gatggcgatg
    12421 ccggccgagt cgtaaccccg gtactccagg cgctggaggc cctccagcag cagcggcgcc
    12481 acgtcgtcgc gacggccgat gtatcccacg attccgcaca taggtgaaac ccctcctgga
    12541 cgtgtgccgg cgggccggtg ggcccgctcg ggtgctcggc gctcccggca tgagggtgcc
    12601 gggcggcctg gtcagccgta gacgatgcgc cgcaactggc gcagggagag tgccgggggc
    12661 gccacggccc tgcgcggcag ctcctcggcg atccgctcga agatctccgt gttgcccagg
    12721 ccctgggcct ggagttcgcg gtgacggcgg cggacgcact cctcggtcgt ctcgtcgaag
    12781 tacgccagga cgtccatgac cacccggccg gcctcgccgc ggctcagcgg cgtggtgcgg
    12841 accaggtggt cgaccaggtc gtcgtggttc gtacggcgtt cgagcacgga tcgatactgg
    12901 gtcgcgcgtc ggagtttcgc aacattcctg cccgatatcg ggcaggaatg aagggggagt
    12961 ggggcggaat gggggattcc ggcgacttcg cgcgacccgg ccgctcagag ccggcgcagc
    13021 accgcctgct tggcgaggct gaactcctcg tccgtgagca ccccgtcctg gtgcagctcg
    13081 cccagctccc gcaacctccg cagcagcgcg tccgggtcgt cggcgggggc ggcctgcggg
    13141 gccggggcgg acggcagcct gagctgggcg ggctcctcgg gcttgtcgag cgcgccgggg
    13201 gtgcgctccg gctcgccccg ggccgccagc gccaccagga ccgccgcggc gaccaggacg
    13261 gccgtgtgct ccttcttcga caggccccac aggtccaggg cgtgcgggtc gtgctcgggg
    13321 gccaccgtct tgccgccacc ggagcgggtg aggaagcgca ggtgcccgtt ctccaggccc
    13381 tgcgggggca cccaggtgac gccggtgagg tcggcgagcg ccagcgtggt cgggccggcg
    13441 gaggtcttgg tctccttgcc cttccagttc caggtcagcc gcacctcgcg cccgtcgaag
    13501 gcggccgtgc cgtccccgcc gccgcccgag accggcaggg cggggccggg cagcaggaac
    13561 cgttcgacgg ggccctcggg aatctgctcc agcagcagcg cctggcgcac ctcggccacg
    13621 acgtactcgg ccaggtcctc ccggcccgac tcgaccacca gccggtaggg gtctgccccc
    13681 tcgggcagcc gtccctcggc cgcccgcacc acagggcagg ccccgtcccg cagccgcagc
    13741 ctgagccgcc cgcccttgcg gtcccgctcg aaggtgatcc cggcgacggc cgccagcggc
    13801 accgccacct cgccgagcac ctgccgcacc ggatgggcct tggcgcccgg cacgatccgt
    13861 atgcgcccgt cctcgtagct ccagctgccg tcccgctgcg tgatctccgc catgcggtga
    13921 ttctttcagc acggaggaga cggcgggcgc cgtccgggga ccgtacccgg gcggcgcccg
    13981 ccgcccgcgt ggggcgggac tcagcggccc gcgagggggt tgaccaggtc gccgacgagc
    14041 tggagagcgc ccgaggggtc ggccaggtcg accatctgct ggttgtcgcg cagctggagc
    14101 cggttgaggc aggagagcgc gaaggtgggc gcgaacatgt cgtactgggc gaacttgtcg
    14161 gccagctgcg gcatggactc ctggtacgcg cggacgctca tcgccgccgt gcgccagaag
    14221 gtgtcctcgt ccaggacgcc ctcgccggcc agggtggcgt tgaggaagcg caggtagcag
    14281 tcgaagacgt cggtgaagat cgagaggatc ttcatctcct ccggcacctc ggccctgatg
    14341 cgctcgaccg cgggcggcag gaccgcgtcc gggtccatga cgcagatctc ctcggcgatg
    14401 tccttgaaga tcacccggtc gaccgcgccg tcctcgatga cgaggatgac gttctcgccg
    14461 tgcggcatgt acaccaggtc gtactggtag aaggagtgca gcaccggcac gaggtacgcg
    14521 tccaggtagc ggcgcagcca cacctcgggg gccagccccg actcggcgat cagcgcgccc
    14581 gccagcgagg cgccgtcggt gtcggtgtgg agcagcgagg ccatggtggc cagccgctgg
    14641 ccctcgccga gctgcggcac cgggctctcg cgccagagcg cggccagcat cttgcggtat
    14701 ggcgagtacc ggtcggtggc ccgctcgtac tggcggtggt ggtagccgat cgcggcgcgc
    14761 tcgcggatga tcgagaagcg cgcggcccgg aagacctcgt caccggcgat gagctgggcc
    14821 agccagtcgt tgatcgccgg ggtggcctcc atgtaggcgg ccgacaggcc ccgcatgaag
    14881 cccatgttca gcaccgacat ggcggtcttc acgtagtgcc tgtcggggtg gctggtgttg
    14941 aagaaggtcc ggatcgactg ctgcgcgagg tacgcgtcgt cgccctcgcc gagcaggacc
    15001 aggcgctgct gggcgacctc ggcggcgaag gagacggaga gcttgttcca ccactgccag
    15061 gggtggaccg gcagcaggtg gtagtcggcc aggtcgagcc cctggccggc gagggtggcg
    15121 gcgaaccggg ccagcgtcgc cgggtccagc tcgcccttga ccagggtgtc gtagtcgagc
    15181 ccggcgccgc tggtgaaggt ggagcggtcg cggcgggcgg cgagccagag cagccggacc
    15241 ggggaggcgg tctcgggggc gtactggtgg tactcgcgga cgtcgaagcc gatccgtccg
    15301 ttgttggcga cgaagcaagg gtggccctcg gtcatccccg tctcgatggc ctggaagccg
    15361 gcgcgggcca gttcggcggc gctcgggcgg gcctgggcca gtttccaggc ggcgccggag
    15421 agggtggagg agatctcctc caggtagacc gggaggatgg cgtcgccgat gcccagcgcg
    15481 gtccgcgtgt cgaggatgaa gtcgagtgcg tccagcggga gttcggtgcc gccctcgcca
    15541 tgccgggtga tcgtgtcggc ggcgatgtcc cagtggtcca ggctcagcag tctcgccgcg
    15601 aagcggtact cggtgacgcc gtcgtcggtc accacgcggt gggcggtgcg gccctcggcg
    15661 tccggctcgg cgccgggcag cggttcgggc gtcagcagcc gctcgtggga gaactcggcg
    15721 aggcccttgc ggaccaggtg gcgcccggcg gcggcccaca gctccggggt gaggtgcgcg
    15781 gtgggggcgg cgagctggtc ggtggggctg gtgtcactca tcggggagcc tgctccttcg
    15841 tgtcgtcccc cgcctgtacg gtcgccgcct tcttcgcggc ctcgaaggcg tcccgggtgc
    15901 agacgctcag gtacgcctcc ttctcgggct tggcgatctt ccgggcgatc tcgaaaccga
    15961 cggcctcgtt cagcgcgtgg acggccgcgt tgcgcacgtc gggctcgacc acgacgcgga
    16021 cggtgtccgg gtcggcgaag aggtactcca tgaccgcgaa gatcaccgcg cgggtgaagc
    16081 cgtgcagcgg cgtgtcggtc ggcgcgcaga ggaagtgcat gccgacgtcg ccgggctcgg
    16141 ggtcgtagag gccgaccagc tccacgtggg cggggtcgta ccgctccatg aggaaggccg
    16201 gggagtcctc gtacagcccg atgaaggcgt cgtggtgggg gtggtccgcg atcgaggcgt
    16261 actcgccgcg gacctcgtcg acgctgagct cctgcatcag ccagaaggcc gatttcgggt
    16321 gggtgaccca gccgtggacc aggccggcgt cggcgtccag gtcgaggggg cgtatcgcga
    16381 gccggtcggg gcggactttc gcggtgcggg gggtggtcat acggagaact cctggaaggc
    16441 gatcgacttc tccaccgcgt agggggcggt gcccagcagc tcgcgcagga tgacggagtt
    16501 gcggtaggcg cccatgccca ggtcggggga ggtgagggcg tgggagtgga cgccggcgtt
    16561 ctgtacgaag atgccgcgcc cggtggtgtc gatgctgtag ttgcgggcga tgtcgaaccg
    16621 gccgcgcccg tcccagcgga tgcggtcgcg gaccggctcc aggaagtcgg ggacgcggta
    16681 ctggtagccg gtggccagca ccaggccctc gctggtcagg tcgaagtcct tgccctgctc
    16741 ctcctggcgg agccccaggg tgtacgtgcc ctcggactcg tcccaggtgg cggtccgcag
    16801 ggcggtgttg gtgaggagcc gggtggggac ggggccgcgc acgttcttct cgtagagcag
    16861 gtcgaagatg gcgttgatga gttcgccgtc gatgcccttg aagaggttct tctgcttctg
    16921 ctccaggccg taccgggtgt cctcgggcag cgcgtggaag tagtcgatgt actccgggga
    16981 ggtcatctcc agcgtgagct tggtgtactc cagcgggaag aaccggggcg agcgggtgac
    17041 ccagttcagc tggtagccgt ggacgtcgat ctcggcgagc aggtcgtggt agatctccgc
    17101 cgcgctctgg ccgctgccga ccagggtgat cgacttcttg gcctggaggg ctgctttgtg
    17161 ctccaggtag cgggagttgt gcagcaggtc gccgccgagg tcccggcagg gctcggggat
    17221 gtgcggcggg gtgccggtgc cgagcgccag gtgccgtgcg cggtaggtgt cgccccggtc
    17281 ggtggtgacg gtgtagagcg cgctctgatc gtcgtacgtc acctcggtga cggtggtcga
    17341 gaagcggacc gagccgaggc gggcggcggc ccagcggcag tagtcgttgt actccgtgcg
    17401 cagcgggtag aagttctccc ggatgtagaa ggagtacagc cgcccggact ccttcaggta
    17461 gttgaggaag gagtagggcg aggtcgggtc ggccagggtg accaggtcgg acatgaacgg
    17521 cgtctggagg tgggcgccgt ccaggaacat gccggagtgc cagtcgaagt ccggcttcgt
    17581 ctccaggaag agcgcgtcga tctcgtccag cggctcggcg aggcaggcca gcccgaggtt
    17641 gaacgggccg aggccgatgc cgagcaggtc gagcggctcg gcggagtcaa aggcggtgcg
    17701 ggacgatcgc tcaggaggcg tggacaagag actctcccag gtactgctcg gcgtggccgg
    17761 ctatgaggtc gaggacggcg gcgatgtcgg acgccttcgt ctcggggttg agaagggtga
    17821 acttgaggta gtgccgcccg tccaccttgg tgcccgccac gacggcgtca ccggaggcga
    17881 acagggcctt gcgggcgtac aggttggcgc ggtcgatctg cgccgggtcg gtgggctgcc
    17941 cgggcaggta gcggaagacc agggtggaga gcgagggctc cacgaccacg tcgtagcgcg
    18001 ggtcggcgac gagcagctcc cagccctcgc cggcgaggtc gcagacctcg tcgaagagct
    18061 ggccgacgcc gtcggccccc atcacgcgca gcgtcatcca cagtttcagg gcgtcgaagc
    18121 ggcgggtggt ctggagcgac ttgtccacct ggttggggat gcgctcctcc gcggcccggc
    18181 gcgggttgag gtagtccgcg tggtacgtgg cgtgccgcag cgtggcaccg tcgcggacca
    18241 gcagcgcgga ggaactcacg ggctggaaga aggacttgtg gtagtcgacg gtgaccgagt
    18301 cggcgtgctc gatgccggtg agcagcccgc gccgggtggg ggagaccagc aggccgcagc
    18361 cgtaggcggc gtcgacgtgc atccaggtgt tgtgcctggc gcacagctcg gcgatctcgg
    18421 gcagcgggtc gatcgagccg aagtcggtgg tgccggcggt gccgacgacc gccatcggga
    18481 cgaggccctc ggcctcgcag cggcgcagct cggcggcgag cacctcgatc cgcatccggc
    18541 gctcgcggtc ggtggggatg gtcaccacgg cgtccgggcc gaggccgagc agcgtcgccg
    18601 acttgcggac gctgaagtgg ctgacgtcgg aggtgaagac gcgcagctgg gtggggtgcg
    18661 cggccttggc ctcctcgcgg gcgagcagca tcgcctggag gttggactgc gagccgccgc
    18721 tggtgaagac gccgtccgcg ccctcgccga ggccgatccg gcccgccgtc cagtcgatga
    18781 ggcgccgctc gatgagggtg ccgcccgccg actggtccca ggtgtccagg gaggagttga
    18841 ccgccgagag gaccgcttcg ccgagcaccg ccggaatgac gaccgggcag ttgaggtggg
    18901 ccaggtagcg cgggtggtgg aagtagacgg cgtcacgcag gtacacgtcg gtcagctcgt
    18961 ccagcgccgc ggcggtgtcg ccgagcgggc ggtcgaggtc gactgcgtcg accacggggg
    19021 cgagcgcggc cggggtgacg ccggtgaacg ggctggtggc acctgtcagc gatgcggcaa
    19081 cgcgctcgac accttcggtg acggagcggc ggtacgcctc cacgttcagg tcgttcagca
    19141 ggtgagacct gggcgcgagg agactcatga gcggtcctcc cggtgagggg actggggatg
    19201 ctcctggggg tgagcaccac atgggggcga tgaacttagg tgagcctaac ctaatgtcga
    19261 cctgaggaag tatgcaggga gtgattcccg tcaactgtgg ccggatgcag agcgattggc
    19321 cgtgaagcgt gcatcggggg cggggttcgc gaccgaagta tccgccttcg cgctccttgt
    19381 tcgggtggtc ggagtttgcg gtgagtgcgt ggggaacgtg tctgtatctg acctcgcgtc
    19441 agtcgggtgg accgcaaagg gccccgccca cccctctcca gggtgcgcgg ggcctggttc
    19501 ctcaggccgt acgccgttcg ccggtcgcca gcgactccgc gcgcagctgc tcctcgctcg
    19561 caccctcacg ccagtacccg acgaaggtca ccgcccgccg gtcgaagccg cgctcgccca
    19621 ccaggtggcg gcggagcgtc cgcatccggc ccgcctcccc ggctatccac acgtacggct
    19681 cgcccgtggg cagctccgcc gcccggaccg cctccgccgc cgagggggcg ccctcgtccg
    19741 cgaccagcca ggtgatctcg gcgtccgccg cggtggccag ctcgcgccgg tcctcggcgt
    19801 gcggcacctc gatccacagc cgtaccggga aaccggccgg cagccactcc aggatcgcct
    19861 cggtggccgg cagcgaggtc aggtccgccc acatcagcgc ccaggcggcc gaccccggcg
    19921 gccggaaccg caccgacacg ttctccgtca ccgacgggcc cagcaccacg atccggtccc
    19981 cgggcagcgc ccgcgccgcc catcggcagg ccgggccgct gtcgccgtgc agcgcgaagt
    20041 cgacgtcgaa ctcggtcgtc ccgtcgtccg cccgccgctg cgcccgcacg gtgtacgagc
    20101 gcatcaccgc ccgctcctcc tcgggcatcg cccggtacgc cgcccaccag ttctcgcccg
    20161 cctcgaccgg cacccgcggc acgcgctgcc ccgggtgcgg caggaagagg gagcaactct
    20221 ggtcccggcc gcccgactcg aagagcgcca gctcctcgcc gccgaaggtg agccgcacca
    20281 gcgagggcga cagacgtcgg ctgccacgca cctccacgtc gaagaagcgg aacggcgtac
    20341 gggcgggagc ggtgggcgtg gtggtcatga gacgggcctt ccctcggcgt cgaaatggcg
    20401 ctgaggtaag cctaacctca ccattgcggc gtggggagag gcagggggcg ccctcgcgcc
    20461 ggcggctcag cggggcagcc ccgcctccgc gatggccagt acctcggtga tggcctcgcc
    20521 cggggtgccg gtgcccgggg cggtgttcca ggcccattcc tcgacggcca cgcggagggc
    20581 ggtgttgagc agggcggcct ggacgcgggg ttcgagggcg tccggggaga ggccggtacg
    20641 ggccgcgaag acgcgagcga ggaccggttc ggccgcgtgg tggacctgga gccagaccgc
    20701 gcgcagcccc ggctcggcgc ggaccaggcg gaccaggtcg cgcagcgcct gctcgtcctc
    20761 ggcgagagcg gtggccgaac ggccgggcgg atacgcgctg atgccgtcgg tcagggtgcg
    20821 ctcgcgcggc caggaggtga gccgttcggc agccgcgtcc agggccgtgg tcagcagcgg
    20881 gccgacgcac tcctccttgg aggagcagta ccgccacagg gtgcgcgggg agatcccggc
    20941 cgccgccgcg atctcgtcgg cggtggtggc cgcgacgccc tgggccgcga agaggcggac
    21001 cgcctcgcgg gcgatctcca ggcgcgtcgc cgccttgcgc cgctcggtca gcggcggccg
    21061 gccgacccgc cgcccgtcct tctccgctgt cacaccctca ccccgtcccg cgtcccggcc
    21121 gtcacctgcg gtgatcctac gtcggcggcc cgatcgcacg gtctttgtgg cgcgccccgc
    21181 cttaatggcg cactccgcca ttaagggggt accgtcgatc gtgcgcaccc cctgaaccct
    21241 ggagcacccc atgagcacca ccaccggcct cgcgggccgc gccgtcgtcg tcaccggagc
    21301 cgggtccggc atcggcaggg cggcggccct gcgcttcgcc ggcgagggcg ccaaggtcct
    21361 cctcgccgac ctgaacggcg aggccgccga ggccgccgcc cgggagatca ccgaggcggg
    21421 cggcaccgcc gtcaccgtcg ccggcgacct cggcgaccag accgtcgtcg accaggtcgt
    21481 cgccaccgcc gtcgagcggt tcggctccct cgacgtcctc gtcaacaacg ccgggatcat
    21541 ggaccgcatg tcggccgccg gggagaccga cgacgccgag tgggagcggg tcgtccgggt
    21601 caacctcacc gccccgttcc tgctgacccg cgccgcactg ccgcacctgc tcgccaccgg
    21661 caggggcgcg atcgtcttca ccgcctccga ggcgtccctg cgcggcagcg ccgccggtgc
    21721 cgcgtacacc gcctccaagc acggcgtcgc cgggctcacc aagtccgtcg ccgtcatgta
    21781 ccgcgagaag ggtctgcgcg ccaacgccat cgcgcccggc ggcaccgcca ccaacatcca
    21841 ggtcgacgcc gaccgcgagg cccacggccc cgccgtcctc ggctcctaca tgcgcaacgt
    21901 cggcagcccc gcccaggccg aggagcaggc cgcggccatc gtcttcctcg cctccgacgc
    21961 cgccagcaac atcaacgggg tgatcctccc ggtcgacggc gggtgggccg ccgtctgagc
    22021 ctccggcccg ccgtacggtc gtcgtggtga agggcgcggc ccccgctccg gggccgcgcc
    22081 gcagcgaccg cgcgaggagc cgccgtgaac caggacgagg aacagatccg ccgcctcatc
    22141 gaggagtggg cgtccgccgt ccaccgcggc gacctcgcca ccgtcgtccg cgaccacgcc
    22201 gacgacctcg tgatgtacga cgtgccgccc ccgtacgagg gggtgcgcgg cctcgacgcc
    22261 taccgggcag tctggcccgc cttcttcgcc tggcaggcgt ccggcgcgga gttcgccctc
    22321 gacaccctcg acgtcacggc cggccaggac gtcgcgtacg cccacgccct cctgtgctgc
    22381 ggcacccccg aggagctggc cgaacgcccg gcgctgcgac tgcggttgac gctgggactg
    22441 cgcaaggagg acggccggtg ggtggtcgcc cacgagcatc actcgttccc ggacctctcc
    22501 tcggcgtccg agccgccctc gccccagcac tcctcctcgt agctgagcag gtcgccgggc
    22561 tggcactcca ggacccggca gatcgcggtg agggtggtga agcggatcgc cttggcgcgg
    22621 ccgttcttca gcacggagag attgacgttg gtgacgccga cgcgggcggc gagttcggcc
    22681 agcgtcatcg agcgggcctc caggagccgg tccaggtgga cctggatcgc gtggccgtcg
    22741 tcctcgggcg gcatcagacc accgcgtcca gctcgtcgcg caggtccgcc gaggcgccga
    22801 cgatccgggc gaaggtcagc agtccgagcc ccgtgaggac ggcgaggaag ggggcggacc
    22861 agagctgggt ccaggccgcg ccggccacct cgtcgtcggt gagggtgttg agcagcgcgc
    22921 cgcccgccac cgcttcggcc gtctccacga cgaggctgcc gagcagcagc caccagccga
    22981 ggacgcgcag ccgggccgcc gcgccccgcg tgtggacgcc ctcgcgcacc gccagccgca
    23041 gcagtcggtc cagcaggtaa agcccgccga tcagcatcac cgtcagcggc gcggtccgca
    23101 ccacgcccag cacctgctgc caggtggtcg gttcctcggc gcagaagcgg ggcgtgtagc
    23161 cgacccccgc ccccggcaac ggttcgaagg gatggaagtc accgccgctc gtggaggccc
    23221 agtccaccgt gacgcacagg tccccccggc cccagtgcac cccgtcgacg aacaggctga
    23281 gcaggaaacc cgccacgaac aaccccagca ggatgcgcag ggtgaccgag acgacgctgg
    23341 tcaacggctc cagcatcttg cggtcctcgg gcatggctga ccccctgtgg gttcatgtct
    23401 ctcgataaca tcgataaacg atatggcccc cagggtctga ccgtccagcc cccgcccctt
    23461 tccgatcccg ccctcccgca cccgacgcca tggcccgcgg cggcctcacc gcccctgaca
    23521 ccggccgccc cgcctgtcct cggcggcgag gacgttcgta cgctgtgcgc tgtccgtcct
    23581 cgccaccgca ccgcacagga gatcccatgg accagcgagg ccaggccatc ccttccgtgg
    23641 accgcacggt cacctaccgg gaggacccgc cccgcacctg gacccggatc tgcctcgccg
    23701 cctacgtcct ctgggccgta taccaggcgt tccaactcct cccggacgag ctcaccgcct
    23761 ggctggtcgt ctgcgccatg tccctgctgc tcctcctctg cctcctcgcg gtccccctct
    23821 ccaaacgcct ctaccaccgc atccgcctcg ccgacggcga actgcgcgta ggccgcgaac
    23881 gccttcccgt cgcctccctc acccccgtct ccctcgcggc cgccgccgac gaaccgggcc
    23941 gcgccggcct acgcgcatac cgcgcctccc tcacccccga ccagctcaag gaagcccgcc
    24001 gccgcaccaa cgccctcacc cggccgcgac tggtgggcgg ggcgtgggcg gtcccggtcg
    24061 gcatggagga actggtggtg gagacggcgg agggcgcgtc cctggtcatc gccacgcggg
    24121 accgggccgg gctgctgggg gcgttgactc gggcgcgggg gatctgaggc tccgcccgag
    24181 gcggctcacg gtggtgagcc ggctggtgga cctcctgaag gcaagggtgg gtaagacgga
    24241 cgctcggccg ttgccgcttc aagtggcagc actggaaggc gagttgtgtt acatgattcg
    24301 gcgctgcggc caggggcggg agaacacggg gtcgcgggag agtgagtaca acctgcaacg
    24361 ctggaaggaa cgatcgggct cccggtggcg ccggaagcgc ggctaccggg gttcgctggg
    24421 cgagttcggg cgcgtcgcgg tggagacctc cgcccagcct cggaggcccc tctacggcac
    24481 ggggatccgc ggggagtccg tcccccctgg tggcctccag cgggtggcct cttgggacaa
    24541 gccctccctg ctcctcgggc agctcacggt ggccggggag ggcgtcccgc tccgccgtaa
    24601 ccggtgggcg ctcagcaagc agggccgtgc cctgcgattc gaggtggccg gtcgcacgta
    24661 ccgctactac gcgaccagcc cccggcaccg tcaccgcgcg ctggcacgag agggtatgga
    24721 gatagagacc ctccggccgc gccgcgggga gggggagagc gcgaccgtga gcctcccggg
    24781 gcacgccgac gccacgtatg tggcgctggc gctggtgatg tgcggggtca gcactcgcaa
    24841 cctcacccag ggcggtgccg tgcgaacctt tttcaaccgg gtcctcccta ccggagtgac
    24901 gcggggggct cacccccgcc ccccacccac ccccaactcc cgcgcgatca gcatccgctg
    24961 gacctcgctc gtgccctcgc cgatctccag gatcttggag tcgcgccaca tgcgggcgac
    25021 cgggtactcg ttcatgaagc cgtagccgcc gtggatctgg gtggcgtcgc gggcgttgtc
    25081 gacggcgacg gtggaggagt ggagcttggc ggcggcggcc tgcttcttga agggttcgcc
    25141 ggcgaccagg cggctggcgg cgtcgcgcca ggcgaggcgg gcggtgtagg cgcgggtgtc
    25201 catgtcggcg atcttgaact ggatggcctg gttggagccg atgggcttgc cgaaggcgtg
    25261 gcgttcggcg gcgtacttga ccgactcgtc gacgcagccc tgggcgaggc cggtgcccag
    25321 ggcggcgatg gcgatgcggc cctcgtcgag gatgcggagg aactgggcgt agccgcggcc
    25381 ttgttcgccg aggaggttgg cggcggggac gcggacgtcg tcaaaggaga gctcgcgggt
    25441 gtcggaggcg ttccagccga ccttggagta gggggcggcc acggtgaagc cgggggtgcc
    25501 ggacgggacg atgatcgcgg agatcagcgg ggagccgtcg ggcttgcggc cggtgacggc
    25561 ggtgacggtg accaggccgg tgatgtcggt gccggagttg gtgatgaagc acttgccgcc
    25621 gttgatgacc cactcgttcg tcgcctcgtc gagtcgggcg gtggtgcggg tcccgcccgc
    25681 gtcggagccg gcgccgggct cggtgaggcc gaaggcgccg aggatctcgc cggagcacag
    25741 gcgcggcagc cacgcgcgct tctgctcctc ggtgccgaag aggtggatcg gcatggcgcc
    25801 gagcgagacg cccgcctcca gggtgatggc caccgaggag tcgacgcggg ccagttcctc
    25861 cagggcgatg ccgagggcga ggtagtcgcc gcccatgccg ccgtactcct cggggaaggg
    25921 caggccgaac aggcccatgc ggcccatctc gcggacgatc tcgtagggga actcgtggcg
    25981 ctcgtagagg tcgccgatct tgggggcgac gacatcgtgg gcgaacgcct cgacggtacg
    26041 gcggagttcc tcgtgttcgg cggagagccg gtggtccagg gacatcgggt acgactccta
    26101 gtgagctgcg gcgacggggt acggcggcag agcgggggag cgtcctactc ctggtgggag
    26161 agggcgcgga cggtgcggga cgggctgggg cggcccagcc gggcggcgag ccagtcgctg
    26221 gtggcgacga gcgcgccgag gtcggtgccg gtgtcgatgc cgaggccgtg cagcatccag
    26281 accaggtcct cggtggcgag gttcccggtg gcgctcctgg cgtacgggca gccgccgagg
    26341 cctccggcgg aggcgtccac gacggtgacg ccgtgctgga gcgcggcgag ggtgttggag
    26401 agggcctggc cgtaggtgtc gtggaagtgg acggcgaggg cgccgggttc gacgcccgcc
    26461 gcgtgcagtg cgcgcagcag ggagccgacc tggccggggg tggcgacgcc gatggtgtcg
    26521 ccgagggaga gctcgtcgca gcccatggcg tgcagggcgg cggcggcccg gaccacctgg
    26581 gcctcgggga ccgggccctc ccacgggtct ccgaagcaca tggagaggta gccgcggacc
    26641 cgcaggccct cggccttggc gcgcgtgacg accggctcga acatggcgag ggactcggcg
    26701 acggtccggt tgaggttgcg gcgggcgaag gtctcggtgg cggaggcgaa gaccgcgacg
    26761 tgccgggcgc cgagggccag cgcccggtcc aggccgcgcg cgttggggac cagtacgggc
    26821 aggtcggtgc cggcctcgcg cacctcgtcc agcatcggga agagctgttc ggcgtcagcg
    26881 agttggggca cccactcggg gcggacgaag ctggtcgcct ccacggtggt gagcccggcc
    26941 gccgcgaggc gccgtacgaa ctcggccttg acgtcggtgg ggacgaccgt cttctcgttc
    27001 tggagcccgt cgcgcgggcc cacctcgtgg atacggaccc gggagggcag cccgtcggcg
    27061 cggaccacca tgggcaggcc cgggacgccg ggcccggtgg cgggggcggg cgattccgtc
    27121 atgcctgggc ctcctcggcg ggggcggcgg gagcctgccg tacgacggcg gtctcggcgg
    27181 gggcttcctc gctggggacc tcgggggcct ccggcggggt gacgacggcg aggacctggt
    27241 ccatggcgac cgtggtgccg ggggagacgt cgagttcggt gacggtgccg gcgtgcgggg
    27301 cgcagatgag gtgctccatc ttcatcgcct cgaccaccag caggccctgc ccctcctcga
    27361 cctcctcgcc gacggcgacc ttgaccagtg tcaccgtgcc cggcatcggc gccgtcagcg
    27421 ccttcgcccc ggccgcccgg tcggccccgg ccagcgcctc ggcgaccggg tcgacgtcgg
    27481 tgacctgcca ggcgtcgccc tcgcgggcca gccactgccc ggcccggcgg aaggagtggc
    27541 gtacgccgtc gagggtgacg tcgaccgagt cctcggtgag ccggtgggtg ccgggggcct
    27601 cggcggtgta cgccacggtc tcctggccgt ggacgcggag atggtggacg accggtgcgg
    27661 gcgggcccgc cagccgccag ccgtcggcgg cggcgaacgg gtcgctccag ccccgggcgt
    27721 cggggacggg ggccagtgcg gccaggcgga cggcggccgc ggcctcgtag acctccggcg
    27781 ggacgcccgg gtcggcgagg gcgtcggcct cgcgggcgac gaggccggtg tcgagggcgc
    27841 ccgcgaccac gtccgggtgg gcgaggaggc ggcgcaggaa cccggcgttg gtggggacgc
    27901 ccagggtgac ggtgccggcg agggcggcgc gcaggcggcg cagggcggtg gggcggtcgg
    27961 ggccgtaggc gatgaccttg gcgagcatcg ggtcgtagac gctggtgacc tcggtgccct
    28021 cgctgaggcc ggagtcggtg cggatgcccg ggccggtggg ctcggcgagg gcgaggacgg
    28081 tgccgccgga ggggaggaag ccgcgggcgg ggtcctcggc gcagaggcgg gcctcgacgg
    28141 cgtggccggt gagggtgatg tcgtcctggg cgaaggggag cggttcaccg gcggccaccc
    28201 gcagctgcca ctcgacgagg tcgacgccgg tgatcagctc ggtgacgggg tgctcgacct
    28261 ggaggcgggt gttcatctcc atgaagcagt acccggccgg gtcgtcgccc gggacgatga
    28321 actcgaccgt cccggcgccg gtgtagccgc aggagcgggc ggcctggacg gcggcctcgc
    28381 ccatcgcggc ccgggtcgcc tcgtccagca ggacgctcgg cgcctcctcg acgatcttct
    28441 ggtggcggcg ctggagcgag cactcgcgct cgccgaggtg gacgacgtcg ccgtggccgt
    28501 cggcgagcac ctggatctcg atgtgccggg ggcggtcgat ccaccgctcc accaggaggg
    28561 tgtcgtcgcc gaaggaggcg cgggcctcgc gccgggcggc ggcgatctcc tcggcgagcg
    28621 ccgcctcctc gcggaccagc cgcatcccct tgccgccccc acccgcggac ggcttcagca
    28681 ggacgggcat gccgatctcg cgggcggcgg cggccagctc ggcgtcggtc aggccgctgc
    28741 ccgaggagcc ggggacgacc gggacgccgg ccgcgcgcac cgtctccttg gcgcggatct
    28801 tgtcgcccat cagcgcgatg gcgtcggcgg gcggcccgat gaagaccagc ccttcctcgg
    28861 cgcaggcccg cgcgaaggcg gcgttctcgg cgaggaagcc gtacccgggg tggaccgcct
    28921 gggcgccggt gcggcgggcc gcctccagca ggcgggggat gtgcaggtag ctctcggcgg
    28981 cggccgccgg gccgatccgt accgccgcgt cggcctcgcg gacgtgccgg gcgtcggtgt
    29041 cggcgtcgct gtacaccgcg accgagcgca cccccagctc gcgcagggtg cggatgacgc
    29101 gtaccgcgat ctcgccccgg ttggcgacga gcaccgtgtc gaacatggtt ctggctcctc
    29161 ctggtgcggc gggggcgctg cgtggtgcct ggtcggtggc catgccgctc acatccggaa
    29221 gacgccgaag ccctgggcct cggagtcgcg cgcggggacc ggcgcctggg cgcaggcggt
    29281 cagggccagg ccgacgacgc ggcgggtctc cagcgggtcg atgacaccgt cgtcccagag
    29341 gcgggcggtg gcgtagtagg cgtcgccctg tgtctcgtac tgggcgcgga ccggtgcctt
    29401 gaactcctcc tcggcctcgg cgggccactc ctcgccgcgc gcctccatct ggtcccgctt
    29461 gacggtggcg aggaccgagg cggcctgctc gccgcccatc acggagatct tggcgttggg
    29521 ccacatccac aggaagcggg ggctgtaggc ccggccgcac atggagtagt tgcccgcgcc
    29581 gtacgagccg ccgatgacga cggtgagctt ggggacgcgg gcgcaggcga cggcggtgac
    29641 catcttggcg ccgtgcttgg cgatgccgcc cgcctcgtag tcccggccga ccatgaagcc
    29701 ggagatgttc tggaggaaga gcagcgggat ggagcgctgg tcgcagagct cgatgaagtg
    29761 ggcgcccttc tgggcggact ccgagaagag gatgccgttg ttggcgacga tgccgaccgg
    29821 g
//
