LOCUS       NZ_CP106650            22574 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Streptomyces sp. GBA 94-10 4N24 strain GBA 94-10 chromosome,
            complete genome.
ACCESSION   NZ_CP106650
VERSION     NZ_CP106650.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GBA 94-10 4N24
  ORGANISM  Streptomyces sp. GBA 94-10 4N24
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7025021)
  AUTHORS   Ian,E., Malko,D.B., Sekurova,O.N., Bredholt,H., Ruckert,C.,
            Borisova,M.E., Albersmeier,A., Kalinowski,J., Gelfand,M.S. and
            Zotchev,S.B.
  TITLE     Genomics of sponge-associated Streptomyces spp. closely related to
            Streptomyces albus J1074: insights into marine adaptation and
            secondary metabolite biosynthesis potential
  JOURNAL   PLoS One 9 (5), e96719 (2014)
   PUBMED   24819608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025021)
  AUTHORS   Ruckert,C., Busche,T. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-SEP-2022) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
REFERENCE   3  (bases 1 to 7025021)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-NOV-2021
            Assembly Method                   :: flye v. 2.9-b1768
            Assembly Name                     :: GB94_v2
            Genome Coverage                   :: 229.4x
            Sequencing Technology :: Illumina MiSeq;Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495635.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 06:31:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,298
            CDSs (total)                      :: 6,204
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 100 of 216
            Pseudo Genes (incomplete)         :: 164 of 216
            Pseudo Genes (internal stop)      :: 24 of 216
            Pseudo Genes (multiple problems)  :: 67 of 216
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:13:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2877504
            Orig. end                         :: 2900078
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106650.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Wittmann Lab, Saarland
            University, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22574
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="14"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22574
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22574
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12574](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12574)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            381..1841
                     /locus_tag="B591_RS12340"
                     /old_locus_tag="B591_12273"
     CDS             381..1841
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896356.1"
                     /locus_tag="B591_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12273"
                     /product="MFS transporter"
                     /protein_id="WP_023417789.1"
                     /transl_table=11
                     /translation="MRRAARVVGRALRTPVTGPARGIRKVTHAQGAGESGLGRLIELHG
                     VNGAGDVMITVALASTVFFSVPTDEARGRVALYLAVTMLPFTLLAPVVGPLLDRLPHGR
                     RAAMAGSMLARAVLALVLSGAVATGSLEMYPAALGVLVASKAYGVVRSAVVPRLLPQGF
                     SLVKANSRVTLGGLLATGVAAPVGAGLQMIGPGWPLYGACLLFLGGAFLSFRLPPKVDS
                     ARGERRALLAADEQHLAAAVDARWDPVAEPVAEPAAEPVATGADRSDGTRNRGREKDRD
                     KERRRKGPGLRTVGPAVTHALAANACVRCQSGFLIFFLAFLLREHPLTGQSAAVSLAVV
                     GVAAGAGNALGTAVGAWLRARAPEVIIVTVVGALVAVAVSAAVFFGAAVVAVLGAVAGF
                     TQALAKLSLDALIQRDVPELVRTSAFARSETLLQMAWVVGGAIGIALPLRGPLGLSVGA
                     LIVALGWLTTVRALMASARRGASHPRVA"
     gene            1871..2395
                     /locus_tag="B591_RS12345"
                     /old_locus_tag="B591_12278"
     CDS             1871..2395
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415563.1"
                     /locus_tag="B591_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12278"
                     /product="hypothetical protein"
                     /protein_id="WP_023417790.1"
                     /transl_table=11
                     /translation="MTSLPRGGAARQFSPATRRGFAVLGAVSAGLLVLSACDKPTAVAT
                     VTIGSDSVNSEATCWNGGSKIDEKKLQQCLQDKGEGDSGNGAEVKTVKVDTEADVHIGV
                     DPKIADKGWTILMNGQPLTDASNKTFRTIPGSVFFNQQYGASGDSTVLSILENDGSSAT
                     GLWSFKLEKES"
     gene            2416..3141
                     /locus_tag="B591_RS12350"
                     /old_locus_tag="B591_12283"
     CDS             2416..3141
                     /EC_number="3.2.2.26"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0009234 - menaquinone biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643335.1"
                     /locus_tag="B591_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12283"
                     /product="futalosine hydrolase"
                     /protein_id="WP_023422005.1"
                     /transl_table=11
                     /translation="MRLLVATAVPPERDAVARAFGAPDTPEETALPGAVLLRTPGADVL
                     AAGVGPAAAASATSAALTAARLAGNPYDLVLSAGIGGGFAERAPVGAVVAADRIVAADL
                     GAETPEGFVPVTGLGFGTDVHVPPAALVEAAREAGLVPGAVLTVSTVTGSAGRASELLA
                     RHPSAVAEAMEGFGVAEAAAAHGVPVLEIRAISNAIGPRDRDAWRIPAALTALTSAFVR
                     LAPAEAGSPFALARARLVP"
     gene            3209..4105
                     /locus_tag="B591_RS12355"
                     /old_locus_tag="B591_12288"
     CDS             3209..4105
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415567.1"
                     /locus_tag="B591_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12288"
                     /product="1,4-dihydroxy-6-naphthoate synthase"
                     /protein_id="WP_023422006.1"
                     /transl_table=11
                     /translation="MSESGTGGGVRGTADEAGRLSIAYSPCPNDTFVFDAVAHGRVPGA
                     PALDVTFADIDLTNGMAERGEYDVLKVSYAALPWLLDEYALLPCGGALGRGCGPLVLTR
                     EASLPGALAGRTVAVPSERSTAYLLFRLWAADQVPGGVGEIVVMPFHEIMPAVRDGKVD
                     AGLVIHEARFTYQNYGLHKLADMGEHWEATTGLPIPLGAIIARRSLGAGRLTALAQALR
                     TSVRMAWDDPAVSRPYVLAHAQEMDADVADQHIGLYVNEFTADLGEDGYAAVRGLLTRA
                     AAEGLVPPLAPDALRFP"
     gene            complement(4193..4576)
                     /locus_tag="B591_RS12360"
                     /old_locus_tag="B591_12293"
     CDS             complement(4193..4576)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642928.1"
                     /locus_tag="B591_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12293"
                     /product="cold-shock protein"
                     /protein_id="WP_023417793.1"
                     /transl_table=11
                     /translation="MPTGKVKWFNSEKGFGFLSRDDGGDVFVHSSVLPAGVEALKPGQR
                     VEFGVVAGQRGDQALSVVLLDPAPSVAAAQRRKPDELASIVQDLTTVLENVSRSLERGR
                     YPDKASGAKVAGMLRAVADQLDV"
     misc_feature    complement(4624..4633)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.3"
                     /tool="antismash"
     gene            4718..4969
                     /locus_tag="B591_RS12365"
                     /old_locus_tag="B591_12298"
     CDS             4718..4969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950020.1"
                     /locus_tag="B591_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12298"
                     /product="hypothetical protein"
                     /protein_id="WP_023417794.1"
                     /transl_table=11
                     /translation="MSDTTQQTPAPGDRLVKTGGIVFIIGALATLVTVAPLFLGSDPFP
                     TAAYLVSMLMGVGFLIAGAGLVRSISAQRRETRAAVEG"
     gene            5241..5912
                     /locus_tag="B591_RS12370"
                     /old_locus_tag="B591_12303"
     CDS             5241..5912
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142169.1"
                     /locus_tag="B591_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12303"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023417795.1"
                     /transl_table=11
                     /translation="MSRVQVIHSSGVLRSALVALLERERFQVTGSAGFTRASSGTTAAP
                     AAVTVVDSSCPVGAAHLERRSLQGSAKEPTHATPALAAARPGLGLAGAGGGRAALVVLA
                     GAEHPGVLRLAYAAGALGLVDRDGPAGHLATAIRLAAGGGRYVDDGLAVSLLRAMDMPL
                     SPREVRVLSRAAQGDSVAEIARGLCLSHGTVRNYIASATRKVGARNRVDAIRISRAAGW
                     V"
     gene            complement(5887..7911)
                     /locus_tag="B591_RS12375"
                     /old_locus_tag="B591_12308"
     CDS             complement(5887..7911)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018890596.1"
                     /locus_tag="B591_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12308"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023422008.1"
                     /transl_table=11
                     /translation="MTDRHAPGATPRPLLRPALTFARRRKGPLGALAAWSLLESARTFL
                     TGHAVARALDDGFLASDVRTGLLWLLALAAAALTGGLADAGVFRSLGSVIEPLRDSLVR
                     RVVRATLTRAATSPTPADTARVSRLTAQTEIARDAAGGVLLTVRSFLFTSVGALTGLAA
                     LSPRLLPLVLIPLAAGLALFAATLRPMAARQRDLLDADEHLAAFAGRTDHAARDIAATG
                     AAPSVTAEAAPLITAEATAASALARWSAVRVTALGLAAHLPVATLLLAAPTLLSTGLTP
                     GELLAALTYVTTALLPAVNALLTALGTAGSRLLVVLHRLLGEEGDVRGKQADVLGVTDR
                     VRGPGASSHGRADEGPAIPAPPLPGPGHVPEPSRAEPSTLGPRPTRPAPPAATLCGVTF
                     AYGPDATPVLDHLDLTVQPGEHLLVVGPSGAGKSTLLALLAGTAHPRHGQIHLGGHTAR
                     HARTLGTAARVLVPQEPYIFEAPLRDNLTYLAPDAPGSRITEALDTFALTSLATDASRP
                     LRPDRLTPSERRRIALARAWLTPSPLLLLDEPTAHLDAGARAATEPAFASHPATVITVS
                     HHFPVPEPGQRVLLLDGATPYLGTHASLLQESALYRELAAEGGAAFDGGDPEHRVDLGV
                     SGEQPRPGALTTRPEPTRQGPPPPRPGPQQPLRPTPPRG"
     gene            complement(7908..9629)
                     /locus_tag="B591_RS12380"
                     /old_locus_tag="B591_12313"
     CDS             complement(7908..9629)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471139.1"
                     /locus_tag="B591_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12313"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023422009.1"
                     /transl_table=11
                     /translation="MTAAPADADRARATPGPPPDEGRLLREAVRRGRGPAALVLAATVL
                     GAAAAVTLPLTLGRAVDLLIARADAGFWVLLCSALIAAEVATDALVARTGGRTGAATTA
                     WLRRRALAGFLAAPPAATTGTGLPTRLTANALDAGTAPVAAATAAAAGLAPLGGLAGLF
                     LVDPWAGAAFVCGVPLLLMILRALLRDGRAALTTYQEEQGRMARLLTGALTGAATIAAA
                     GTARAEERRVLAPLAGMRAAGERTWRVQGRAAGLSGALMPLLVAAVLAVGGVRLVAGHL
                     TPGDLLALSRYAVLAAGAGALAGALNGWVRAKAGTARVETVTALPPTPHGTRDLPPHGD
                     GTLALCGVHVTRDGIPLLHDITLTLPGGTTTALVGPSGAGKSLLAAVAGRLTDPDQGSV
                     LLDGTDLRTLSADALRRAVAYAFERPALFGTTVADAVACGPLPEADLRQALRRAAADTF
                     TDRLPHGTRTPLAEAPLSGGELQRLGLARAFARPSRLLILDDATSSLDTVTAHLVGRAL
                     TEAPGTRLTVTHRLSAAARADQVVWLDKGRVRGTGPHHTLWHDPAYRAVFGTETDT"
     gene            complement(9790..9921)
                     /locus_tag="B591_RS12385"
                     /old_locus_tag="B591_12318"
     CDS             complement(9790..9921)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611153.1"
                     /locus_tag="B591_RS12385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12318"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_008415578.1"
                     /transl_table=11
                     /translation="MALLDLQAMDTPQEEAVGDLATGSQISLLICEYSSLSVTLCTP"
     CDS_motif       complement(9856..9921)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQAMDTPQEEAVGDLAT"
                     /locus_tag="B591_RS12385_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9790..9855)
                     /prepeptide="core"
                     /locus_tag="B591_RS12385_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="30.10"
                     /molecular_weight="2088.4"
                     /monoisotopic_mass="2087.1"
                     /core_sequence="GSQISLLICEYSSLSVTLCTP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQAMDTPQEEAVGDLAT"
                     /leader_location="[9855:9921](-)"
                     /alternative_weights="2106.4"
                     /alternative_weights="2124.5"
                     /alternative_weights="2142.5"
                     /alternative_weights="2160.5"
                     /alternative_weights="2178.5"
     gene            complement(10001..12574)
                     /gene="lanKC"
                     /locus_tag="B591_RS12390"
                     /old_locus_tag="B591_12323"
     CDS             complement(10001..12574)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507351.1"
                     /locus_tag="B591_RS12390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12323"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_023417799.1"
                     /sec_met_domain="micKC (E-value: 1.2e-226, bitscore: 753.1,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 4.5e-12, bitscore: 44.3,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 0.00018, bitscore:
                     18.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPEYALYSGADRWFYDTPRRAGRAGDGNGNDGHRYALALRPAPG
                     GWESAERGDWFSLAPAGRQLPAQGWKIHVSATPDNAEQVLETVAGICQERATAFKFLAG
                     PALLLHRNTKYADRAGSGKFVTVYPATTAACGELAAELADALKGSAGPVVLSDLRWGEG
                     PVHVRYGAFAPRFTRTADGSLVPAVADPTGRLVPDTRGPAFRLPDWVALPDFLRPHAEA
                     RAAQGTNGLPYTVERALHFSNGGGVYAGSHRETGEAVVLKEGRPYAGLAADGADAVTRL
                     EREYAALRALEGLACVPRVHGLHTVGEHRFLAMEFIPGTPLNTVFARRFPLSAAEPAAE
                     ALAEHTAWALRTHQLVTEAVEALHARGIAFGDLHMNNIMVAPDQLSVTLLDFEAATPAA
                     ERRPQIVANPAFVAPPHLRGTEVDRYALACLRLALFVPLTTLLPLDRDKAAHLADLAAD
                     RYGIDRALFDEAVTELAGPARPEAATPRGRPPVSATDWPAARDSMVAALLASATPDRDD
                     RYFPGDIAQFATPAGGQSYGYGAAGVLHALHTVGARCEEAEEWLIRTTRRPASGTPAGF
                     YDGLTGIAWTLDRLGHREDALRLAHLVAAEPLDALGPGLHSGAPGVALALRDLADGADD
                     PALGKAAGRAEAAALRSAAPGGKAGLLHGPAGTALLCLRRHARTGEPALLDTAATALRQ
                     ELSRCVPGPDGSLVVSEARRTMPYLGSGSAGIAMVLDDYLAHRPDPAFEEARTALLRAT
                     GSAFYIQPGLFRGVAGLLLHLARTTTPVDRAARTALLARQTALLDWHALTYEGQLAYPG
                     EQLTRLSMDLSTGTAGVLLALAATHGEPAAHLPFLPPLRRPTDRP"
     gene            complement(12769..13743)
                     /locus_tag="B591_RS12395"
                     /old_locus_tag="B591_12328"
     CDS             complement(12769..13743)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126551.1"
                     /locus_tag="B591_RS12395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12328"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_023417800.1"
                     /transl_table=11
                     /translation="MTRRTARPLLAATGALALAVTLTACGSGEETAADAGKDAGATRTV
                     KTAMGEVEVPEAPKRVVVLDTAELDSALTLGVKPVGAVRSDAAGGFAGYLPQRELAGIE
                     NVGVIAQPNLEAIAALKPDLILTSKVRDEARYAQLSKIAATVMTENTGYPWKENFQLHA
                     EALGKQKEADRATAAYEKRTAEVTEAVGGPAKAKETEVNVVRFVEGADIRIYGRKNYIG
                     TLLADVGLGRPAVTDKAADGFSYDVSPEKIDLADADVVFTATYGDPEKARETRTTRSAL
                     WRSLDAVKSGAVHKVEDELWIQGIGYTAAQQILDQLEEALTPS"
     gene            complement(13740..14597)
                     /locus_tag="B591_RS12400"
                     /old_locus_tag="B591_12333"
     CDS             complement(13740..14597)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950013.1"
                     /locus_tag="B591_RS12400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12333"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023417801.1"
                     /transl_table=11
                     /translation="MTRPAARLTARDLTLAYEDRTVVPGLDLDVPDGRVTVIIGPNACG
                     KSTTLRALGRLLRPAGGAVLLDGTELARLPTRQIARRIGLLPQTPVAPEAITVADLVAR
                     GRQPHQRWWQQWSAEDERAVTEAMARTATTDLADRPVDALSGGQRQRVWIAMALAQETD
                     LLLLDEPTTYLDLAHQVEVLDLVRRLNREQGRTVVLVLHDLNQAARYADHLIAFREGRV
                     VAEGAPAEVVTAGLVREIFGLECVVVPDPVTGSPLVVPGAPWDARQPAPEPAAPTREES
                     RATP"
     gene            complement(14594..15673)
                     /locus_tag="B591_RS12405"
                     /old_locus_tag="B591_12338"
     CDS             complement(14594..15673)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896363.1"
                     /locus_tag="B591_RS12405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12338"
                     /product="iron chelate uptake ABC transporter family
                     permease subunit"
                     /protein_id="WP_023417802.1"
                     /transl_table=11
                     /translation="MLKAGPVPARVRPAGYVPVRLGAVSLLVPVRAVATGAVLAAVLAV
                     VCVAYLSVGESFVAPGSVVDVLLGRPSPDTLVVGELRLPRMVAGLYVGAAFGIAGALIQ
                     TVARNPLASPDLIGVSQGASAATVAALTFGVTSYAVLPWISLGGGLLAALLVYLFAWRG
                     GLQATRFVLVGVGFAVALRALTTLFLTKGDQTVAQQAQVWMSGSLNGRAWPEAALVGWT
                     LLAALPALVWAARVQRTVTLDDATATGLGAHLGRARLGLVLIGVVLASVATGAAGPVDF
                     VALLAPQIARRLTRTAQIPLVCSALAGAVTVVAADLLARRLFAPTELPVGVLTAAVGAP
                     YLIWLLVTRHGPRATGGTS"
     gene            complement(15681..16745)
                     /locus_tag="B591_RS12410"
                     /old_locus_tag="B591_12343"
     CDS             complement(15681..16745)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018896364.1"
                     /locus_tag="B591_RS12410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12343"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_023417803.1"
                     /transl_table=11
                     /translation="MPPAPPAAPPLAKAPPPASRPRRDSAVHRAAWTVAALVALLVAVV
                     LSLAVGARTVAPGTVVEALFQGATGPDAEVVREMRLPRTLIGVMVGAALAVAGTALQGI
                     TRNPIADPGILGISQGASVGVVLAIAFAGVHTLAGYVWFAFAGAGLAAVAVYAVAAGGR
                     GGATPVKLALSGAAVNALLVSVTTAVLTTSSSALDEFRFWNVGALQGRDAEVAVQVWPF
                     LLVGLALVASSARGLDALALGEDVAKGLGQRVGAVRITAGAGAAVLTGVGVAAAGPVAF
                     VGLAVPHLVRHLAGGDHRWVLPLAALTGPVMLLASDTVGRVLFPPGEVPAGVMTALIGV
                     PFLVALVRGRVVTG"
     misc_feature    16833..16853
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(16834..16854)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.7"
                     /tool="antismash"
     gene            16883..17569
                     /locus_tag="B591_RS12415"
                     /old_locus_tag="B591_12348"
     CDS             16883..17569
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507353.1"
                     /locus_tag="B591_RS12415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12348"
                     /product="HAD family hydrolase"
                     /protein_id="WP_023417804.1"
                     /sec_met_domain="HAD_2 (E-value: 6.2e-08, bitscore: 31.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEHLTSPAAPTPSGPAVPAARPAPGGAGPVVGFDLDMTLIDSRP
                     GIGAAYRVLAAETGVPIDVDLVVSRLGPPLETELACWFPAEQVPAAAARYREVYPSTAV
                     APSLALPGAAQALEAVRAHGGRSLVVTAKNEEHARLHLDHLGLRAELVVGSLWAEAKGG
                     ALRAQGATVYVGDHVGDVRGAQAAGAFSVAVATGGCTPDELRAAGADVVLPDLAAFPAW
                     LAEFAR"
     gene            complement(17640..17855)
                     /locus_tag="B591_RS12420"
                     /old_locus_tag="B591_12353"
     CDS             complement(17640..17855)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="B591_RS12420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="B591_12353"
                     /product="hypothetical protein"
                     /protein_id="WP_023417805.1"
                     /transl_table=11
                     /translation="MADVWAGEKLRLRGVEPEDWRDFRELARDLDGVCAAGPAGPPRSD
                     GNLRGGAAPPGQDGERTAKPYGPAGV"
     gene            18065..19087
                     /locus_tag="B591_RS12425"
                     /old_locus_tag="B591_12358"
     CDS             18065..19087
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507354.1"
                     /locus_tag="B591_RS12425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12358"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_037787187.1"
                     /transl_table=11
                     /translation="MKQPARTAGGAVAEEARPVEGVEGDEPGRAAEWWVALRRTPGAFW
                     RDDVSDFAAALTYYAILAVLPALLVVVIAFGLVSPDTAERFVGQVTAWAPGGSGASLRE
                     VLTRVVRVDSTAWTLLVTGGASALWSASSYLAVSRRALHRMYGVRDRRSPWGKAHRIVA
                     TALALLSLLLVSSLLLMLTEPVAESIGRLLGLDAGVAWAWSVVRWPLLLCLVACLVVVV
                     FRNGPAAARRRAHSIPGGVLAATLWLTASAGLALYASVLSTYSRLYGSLAGIVVFLVWL
                     WLSNVALLLGAQFTAELCRAEGGPGAPACRPGPVEGMAAEDVPAGTDAAQEHGRAPTGA
                     "
     gene            19208..21133
                     /locus_tag="B591_RS12430"
                     /old_locus_tag="B591_12363"
     CDS             19208..21133
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_function="GO:0003997 - acyl-CoA oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950008.1"
                     /locus_tag="B591_RS12430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12363"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_269469413.1"
                     /transl_table=11
                     /translation="MTHGQLGPIHDSLATVTLQSVITEREIPLRHSSISASASVADDLL
                     FATRGEEHLRWRELFSTEEFGHRDLPHRERVELSYRRLRTVAAAIPDPRALALSAPALT
                     ALHEWAGPADPGMATLASIHYNLFLGSLLDHDHAERDLGPWLRMDRIGTFLCTEAEHGN
                     DAVNMETTAEYDRASRQFVLNTPGPGAAKWMPNTSLTGGPKDAVVAARLLVDGRDLGIF
                     LFLTPLSDERGHLPGVSVERLPHTSGAPVDHCATRFHHVRLPHSAMLQGDHGRLSPEGE
                     FESTLGSPRIRFLRSIGRVSMGKLCMSGYSLGATRQAIAVAVRHGSTRLTSGMTKGRRV
                     PLMAHRSHHEPLLDALATTYAATLLHRSVVRQWEVAEEAEREEVDRLVAVTKGWITWAA
                     RETMTTCRERCGAKGLLLTQGIAGQLAANEGTITAEGDNKVIWVKAAGELLMGGFTPKP
                     PSETAPEQRSLRDGTHLQDLMADVERIWHERARTRLRSGGVRGNPMARWNGAVTPALEL
                     VAAHAHRLAGEALLEGTDRVSADEAERIRDLHRLFALRQVAAHSGELLAGERLTAEQVR
                     RLPDEVERVVADLEPHILALTERFFVPENLPGSDPAGLVEAAPEALAAGTEARTGGLRE
                     SEPDAA"
     misc_feature    complement(19223..19236)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(19254..19267)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.71"
                     /tool="antismash"
     misc_feature    19259..19261
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21246..22562)
                     /locus_tag="B591_RS12435"
                     /old_locus_tag="B591_12368"
     CDS             complement(21246..22562)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010643357.1"
                     /locus_tag="B591_RS12435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_12368"
                     /product="cytochrome P450"
                     /protein_id="WP_023417808.1"
                     /transl_table=11
                     /translation="MHDANFAADPQAVYEQLREQGPAGPVELAPGVDATLVVGYETALR
                     VLQNPTSFPRDARRWAALNEGRVPMDSPVLPMMAYRPNALFTDGAVHLRLRKAVTDSLA
                     KLNITRIRRDVEPIADYLIDQFSERGRADLLAEYAKLLPLLLFNKLFGCPAEIGDTLTT
                     EMSAMFDGKDPVRTKARLDACLMQLIAIKRREPADDVISWLIQHPAGLTDEELKDQLVM
                     LMGAGIEPERNLIGNALLELLSGGAGGRGAGMMVEEAVDHVLWHRTPIANYAAHYPAQD
                     TDFGNGVIAPAGSPVLISFAGANSDPALAEARRSAGRGAHLAWGAGSHACPAKDPAQVI
                     AVTAVEKILNALPDLTLGVPEEELQWRPGPFHRALVSLPVAFSPTPATRMAAALQSRGV
                     PQQQVAPATPQPQHTAPASSDGGGRRKGFWSSFLDIFRV"
ORIGIN
        1 agtcgcatgc ggcggagacg ggcagcggac ggagcggacc gctgggccgc gtcgacgtcc
       61 gcgcccgatc gtccagggca cgcccacgcg aaccattctg ggggatcgcg aagaggcgcg
      121 cggccgggag taccgtcgca ggcgcgtgag tgcacgctac cctctcgcgg ccccgtctcc
      181 cacaccgacg tgggaagccg ggccgctcag gggcgtcggc ggcgcgtcgt acgggtgcgg
      241 gcgagcggcc cggcgagggg tggcgcggcc ccgcttcggc cacaggggtt gctcgggaca
      301 cttcgggtca tactcggccc gccagggggc actatcacca cgtgaccgcc tcaggctcgc
      361 cacgcgtgga gcgcagcccg gtgcgcaggg ccgcccgggt tgtgggccgc gcgctgcgga
      421 ctcccgtgac gggcccggcg cgcggcatcc gcaaggtgac gcacgcgcag ggcgcgggcg
      481 agtcggggct cgggcggctg atcgagctgc acggggtgaa cggcgccggc gacgtgatga
      541 tcacggtggc gctggcctcg acggtcttct tctcggtgcc gacggacgag gcgcggggcc
      601 gggtggcgct ctacctggcc gtgacgatgc tcccgttcac gctgctggcg ccggtggtgg
      661 gtccgctgct ggaccggctg ccgcacgggc ggcgggcggc gatggccggg tcgatgctgg
      721 cccgggcggt actggcgctg gtgctgtcgg gggcggtggc gaccgggagc ctggagatgt
      781 acccggccgc gctcggcgtc ctggtggcct cgaaggcgta cggggtggtg cgcagtgccg
      841 tggtgccccg gctgttgccg caggggttct cgctggtcaa ggccaattcg cgggtgacgc
      901 tcggcgggct gctggccacc ggggtggcgg cgccggtcgg ggcggggctc cagatgatcg
      961 gcccggggtg gccgttgtac ggggcgtgtc tcctcttcct cggcggcgcg ttcctctcgt
     1021 tccggctgcc gccgaaggtc gactcggcgc gcggcgagcg gcgggcactg ctggcggcgg
     1081 acgagcagca tctcgcggcg gccgtggacg cccgctggga cccggtggcc gagccggtcg
     1141 ccgaaccggc ggccgaaccg gtggcgacgg gggccgaccg cagtgacggg accaggaaca
     1201 gggggaggga gaaggacagg gacaaggagc ggcggcggaa ggggccgggg ctcaggacgg
     1261 tggggccggc ggtgacacac gcgctggcgg ccaacgcctg tgtgcggtgt cagagcggct
     1321 tcctcatctt cttcctggcg ttcctgctgc gcgagcatcc gctgacgggg cagagcgcgg
     1381 cggtgtcgct ggcggtggtc ggtgtggcgg cgggggcggg gaacgcgctg gggacggcgg
     1441 tcggcgcgtg gctgcgggcc cgggcgccgg aggtgatcat cgtgacggtg gtgggggcgc
     1501 tggtggcggt cgcggtgtcg gcggcggtgt tcttcggtgc ggcggtggtg gcggtactgg
     1561 gggcggtggc cgggttcacc caggcgctgg ccaagctgtc gctggacgcg ctgatccagc
     1621 gtgatgtgcc ggagctggtg cggacgtcgg cgttcgcccg ttcggagacc ttgctgcaga
     1681 tggcgtgggt ggtgggcgga gcgatcggga tcgcgttgcc gctgcgcggg ccgctggggc
     1741 tgagcgtggg cgcgctgatc gtggcactcg gctggctgac gaccgtacgg gcgctcatgg
     1801 cgtcggccag acgcggcgcg tcgcaccccc gcgtggcgtg accctccaac gggcccgata
     1861 gccttcgccc atgacatccc tgccccgcgg cggagccgca cgtcagttca gcccggccac
     1921 gcgccgcggg ttcgccgtcc tcggcgcggt gtccgccggc ctgctcgtcc tgtccgcctg
     1981 cgacaagccg acggcggtcg ccaccgtcac catcggctcc gactcggtga actccgaggc
     2041 gacgtgctgg aacggcggct ccaagatcga cgagaagaag ctccagcagt gcctccagga
     2101 caagggtgag ggcgactccg gcaacggcgc cgaggtgaag accgtgaagg tcgacaccga
     2161 ggccgacgtg cacatcggcg tcgacccgaa gatcgccgac aagggctgga cgatcctcat
     2221 gaacggccag ccgctgaccg acgcgtccaa caagaccttc cggacgatcc ccggcagcgt
     2281 cttcttcaac cagcagtacg gcgcctccgg cgactccacc gtcctctcca tcctggagaa
     2341 cgacggcagc tccgccaccg gcctgtggtc gttcaagctg gagaaggagt cctgacccgc
     2401 ctgcccacgc ccgccgtgcg gctgctcgtc gccaccgctg tcccgcccga gcgggacgcg
     2461 gtggcgcgcg cgttcggggc gccggacacc ccggaggaga cggccctgcc cggcgcggtg
     2521 ctgctgcgca ccccgggcgc cgacgtactg gccgccgggg tcggcccggc cgccgcggcg
     2581 agcgccacct cggcggcgct gacggcggcc cggctcgcgg gcaaccccta cgacctggtc
     2641 ctctcggccg ggatcggcgg cggtttcgcc gagcgggctc cggtgggcgc ggtggtggcc
     2701 gcggaccgga tcgtcgcggc cgacctgggc gccgagacac cggagggctt cgttccggtg
     2761 accgggctcg gtttcggtac ggacgtgcac gtgccgccgg ccgcgctggt cgaggcggcc
     2821 cgcgaggcgg ggctcgtgcc gggcgcggtg ctcaccgtct ccacggtgac gggcagcgcg
     2881 ggccgtgcct ccgagctgct ggcccgccac ccgtcggcgg tggccgaggc gatggagggc
     2941 ttcggtgtcg cggaggcggc cgccgcacac ggcgtaccgg tgctggagat ccgcgccatc
     3001 tccaacgcga tcggcccgcg cgaccgtgac gcctggcgca ttcccgccgc cctcaccgcg
     3061 ctgacctcgg ccttcgtccg cctcgccccc gccgaggcgg ggagcccctt cgccctggcc
     3121 cgcgcccggc tcgtaccgtg agcggtggca gtacgcgcgg cacaggcggc gcgagcagtg
     3181 gcagcagcag ggaaggcgag gcggcgacat gagtgagagc ggtacgggcg gcggcgtccg
     3241 ggggacggcg gacgaggccg ggcggctgag catcgcctac tccccctgcc ccaacgacac
     3301 cttcgtcttc gacgcggtcg cccacggccg ggtcccgggc gcgccggcgc tcgacgtgac
     3361 cttcgccgac atcgacctga ccaacggcat ggccgagcgc ggcgagtacg acgtcctcaa
     3421 ggtctcgtac gcggcgctgc cctggctgct cgacgagtac gccctgctgc cgtgcggcgg
     3481 ggcactcggc cgggggtgcg gcccgctggt gctgacccgc gaggcctcgc tgccgggggc
     3541 gctggccggg cggacggtgg cggtgcccag tgagcggtcg acggcctacc tgctcttccg
     3601 gctctgggcg gcggaccagg tgccgggcgg ggtcggggag atcgtggtga tgccgttcca
     3661 cgagatcatg ccggcggtcc gggacggcaa ggtcgacgcg ggcctggtca tccacgaggc
     3721 gcgcttcacc taccagaact acggcctgca caagctggcc gacatgggcg agcactggga
     3781 ggcgacgacg ggcctgccga tcccgctcgg cgcgatcatc gcccgccgct cactcggcgc
     3841 cggccgcctg accgcactgg cccaggcgct tcgtacctcg gtccggatgg cgtgggacga
     3901 ccccgcagtc tcccgcccgt acgtcctggc gcacgcccag gagatggacg cggacgtcgc
     3961 cgaccagcac atcggcctgt acgtcaacga gttcaccgcc gacctcggcg aagacgggta
     4021 cgcggccgta cgcggcctgc tgacccgggc ggcggccgag ggcctggtcc cgccgctggc
     4081 cccggacgcg ctgcgtttcc cgtgaccgaa acggctggac cacgtacgac gagacctccg
     4141 gatcacgctg gttccggcgg tctcgtcgta ggcgctgaag ggtgcagctc gctcagacgt
     4201 cgagctggtc ggcgacggcg cggagcatgc cggcgacctt ggcgccggag gccttgtccg
     4261 ggtaccggcc gcgctccagg ctgcggctga cgttctccag gacggtggtg aggtcctgga
     4321 cgatggaggc cagctcgtcg ggcttgcggc gctgcgcggc ggcgaccgag ggcgccgggt
     4381 cgaggagcac cacggaaagt gcctggtcac cgcgttgacc ggcgaccacg ccgaactcca
     4441 cccgctggcc gggcttgagc gcttcgacgc cggcgggcag cacggacgag tgcacgaaga
     4501 cgtcgccgcc gtcgtcgcgg gagaggaagc cgaagccctt ctcgctgttg aaccacttga
     4561 ccttgccagt cggcaaagca ctgtcccttc tcgccctgcc gccgtccggc cgcagtgtcc
     4621 tggtcacata tcagggggga tgtacccacg gcgaagctat cccatccgct ccaccccggc
     4681 gcggagatta cgggggccgg gcaactaccc tggacccgtg tccgacacca cccagcagac
     4741 cccggccccc ggcgaccgcc tcgtgaagac cggcggcatc gtcttcatca tcggcgccct
     4801 ggcgaccctc gtcaccgtcg cgcccctctt cctcggctcc gacccgttcc cgaccgccgc
     4861 ctacctggtc tccatgctga tgggcgtcgg cttcctcatc gcgggagccg ggctggtccg
     4921 ctccatcagc gcgcagcggc gcgagacgcg ggctgccgtc gagggctgag cgccatgccc
     4981 cgcccggcac gctccggctc acttccgaac gttccgggcg ccacgcgcgc ccccttccgc
     5041 gccctccccc gctctccggc tcccgccgat gatgggcccg ccgccgatct gcggcgacca
     5101 cggacgccgc cgctccgctg gcggaaccgt ttcgccttcc ggacggcgac ggccgtcggc
     5161 caaggctgaa cagtgagggc gccgcctccc acccggagcg cgacgccacg ctgagtctcc
     5221 ggaaagcgga aggcggaacg atgtctcgcg tacaggtgat ccacagctcg ggtgtcctgc
     5281 gatcggccct ggtggccctg ctggaacgcg aaaggttcca ggtcaccggc tcggccggct
     5341 tcacgagagc ctcgtccggc accaccgccg cccccgccgc ggtgaccgtc gtggacagct
     5401 cctgtcccgt gggagcggcc cacctcgaac gccgctccct gcaaggctcc gccaaggaac
     5461 ccacccacgc cacccccgcc ctcgccgccg cccggccggg gctgggcctc gccggagcgg
     5521 gcggggggcg agcggccctg gtcgtcctcg ccggggccga acaccccgga gtcctccgcc
     5581 tcgcctacgc ggccggcgca ctcggcctgg tcgaccgcga cggccccgcc ggccacctgg
     5641 ccaccgcgat acggctggcc gccgggggcg ggcggtacgt ggacgacggg ctggcggtga
     5701 gcctgctccg ggcgatggac atgccgcttt caccgcgtga ggtgcgggtg ctgagcaggg
     5761 ccgcgcaggg ggattcggtg gcggagatcg cgcgggggtt gtgcctgtcg cacgggacgg
     5821 tgcggaacta cattgcttcg gccacccgga aggtgggggc caggaatcgg gtggacgcga
     5881 ttcggatcag ccgcgcggcg gggtgggtct gaggggctgc tgcgggcctg gacggggtgg
     5941 gggcgggcct tggcgagtgg gctcggggcg ggtcgtcagt gctcctgggc gtggctgctc
     6001 cccgctcacg ccgaggtcga cgcggtgctc cggatcccca ccgtcgaagg ctgccccacc
     6061 ctccgctgcc agttcccggt acagggccga ctcctgcagc agcgaggcgt gggtccccag
     6121 gtaaggcgtc gccccgtcca ggagcaggac gcgctgccct ggttcgggta ccggaaagtg
     6181 atggctcacc gtgatcaccg tggccgggtg ggaagcgaaa gccggctccg tggcagcccg
     6241 cgcccccgcg tccaggtggg ctgtgggctc gtccaggagg agcaggggcg aaggcgtcag
     6301 ccacgctcgg gcgagggcga tgcgacggcg ttcggacggg gtgaggcggt ccgggcggag
     6361 agggcgggac gcgtccgtcg cgagggaggt cagggcgaag gtgtcgaggg cttcggtgat
     6421 gcgggagccg ggggcgtccg gggcgaggta ggtgaggttg tcgcggagag gggcctcgaa
     6481 gatgtagggc tcctggggga cgaggacgcg ggcggccgtg ccgagggtgc gggcgtggcg
     6541 ggcggtgtgg cccccgaggt ggatctggcc gtgtcggggg tgggcggtgc cggcgaggag
     6601 ggcgagcaag gtggacttgc ccgcgccgct ggggcctacg accaggaggt gttcgccggg
     6661 ttggacggtg aggtcgaggt ggtcgaggac gggggtggcg tcggggccgt aggcgaaggt
     6721 cacgccgcac agggtggcgg cggggggtgc cgggcgggtg gggcgaggcc ccagggtcga
     6781 gggttccgcg cgggacggct caggcacgtg tccggggccg gggagcgggg gcgcggggat
     6841 ggcggggccc tcgtccgccc tcccgtgcga gctggccccc ggcccgcgta cgcggtcggt
     6901 gacccccagc acgtcggcct gcttgccccg cacgtccccc tcttccccca gcagtcggtg
     6961 cagcacgacc agtagccgcg accccgccgt gcccagggcg gtgagcaggg cgttgacggc
     7021 ggggaggagg gcggtggtga cgtaggtgag ggctgcgagg agttcgccgg gggtgaggcc
     7081 ggtggagagg agggtggggg cggcgaggag gagggtggct acggggaggt gggcggcgag
     7141 gccgagggcg gtgacgcgga cggctgacca gcgggccagg gcggaggcgg cagtggcctc
     7201 ggcggtgatg aggggggctg cctcggcggt gaccgacggg gctgcgccgg tggcggcgat
     7261 gtcgcgggcg gcgtgatcgg tgcggccggc gaaggcggcg aggtgttcgt cggcgtcgag
     7321 gaggtcgcgt tggcgggcgg ccatggggcg gagggtggcg gcgaacaggg ccaggccggc
     7381 ggccaggggg atcaggacga gggggaggag cctcggggag agcgccgcca gtcccgtgag
     7441 ggcgccgacc gaggtgaaga ggaaggagcg caccgtcagc aggacgccgc cggccgcgtc
     7501 gcgggcgatc tcggtctggg cggtgaggcg ggagacgcgt gccgtgtcgg ccggggtggg
     7561 tgaggtggcg gcccgggtca gggtggcgcg gaccacgcgg cggaccaggg agtcgcgcag
     7621 gggttcgatc acgctgccga gtgagcggaa gaccccggcg tcggcgaggc ccccggtgag
     7681 ggctgcggcg gcgagggcga gcagccagag gaggcccgtg cggacgtctg aggcgaggaa
     7741 gccgtcgtcc agggcgcggg cgacggcgtg gccggtgagg aaggtacggg ccgattcgag
     7801 gagggaccag gcggccagcg ccccgagcgg acccttgcgg cggcgggcga aggtgagggc
     7861 ggggcgcagg agggggcggg gcgtggcgcc aggggcatgc cggtcggtca tgtgtccgtc
     7921 tccgtgccga agaccgcgcg gtaggcgggg tcgtgccaga gggtgtggtg ggggcccgtg
     7981 ccgcgcacgc ggcccttgtc gagccagacg acctggtcgg cccgggcggc ggcggagagg
     8041 cggtgggtga cggtgaggcg ggtgccgggg gcctcggtga gggcgcggcc tacgaggtgg
     8101 gcggtgacgg tgtcgaggct ggaggtggcg tcgtccagga tcaggagacg ggagggacgg
     8161 gcgaacgccc gtgccaggcc gaggcgttga agttcgccgc cggagagggg ggcttcggcc
     8221 aggggggtgc gggtgccgtg cgggaggcgg tccgtgaagg tgtcggcggc ggcgcggcgc
     8281 agggcttggc ggaggtcggc ctcgggcagg gggccgcagg cgacggcgtc ggcgaccgtc
     8341 gtgccgaaga gggccgggcg ttcgaaggcg tacgcgacgg cgcggcgcag ggcgtcggcg
     8401 gagagggtgc gcaggtcggt tccgtcgagg aggacgctgc cctggtcggg gtcggtgagg
     8461 cggccggcca ccgccgccag cagggacttg ccggcgccgg acgggccgac gagggcggtg
     8521 gtggttccac cggggagggt gagggtgatg tcgtggagga gcggtatgcc gtcgcgggtc
     8581 acgtggaccc cgcacagggc gagggtgccg tcgccgtgcg gggggaggtc gcgcgtcccg
     8641 tggggggtgg gcggcagggc ggtgacggtc tcgacgcggg cggtgcccgc cttggcccgt
     8701 acccagccgt tgagggcgcc ggccagcgct ccggctccgg cggcgaggac ggcgtagcgg
     8761 gagagggcga ggaggtcgcc gggggtgagg tgaccggcga cgaggcgtac gccgccgacg
     8821 gcgaggacgg cggcgaccag gagtggcatc agggcgccgg agaggccggc ggcgcggccc
     8881 tggacgcgcc aggtgcgctc gccggccgcg cgcatcccgg ccagcggggc gaggacgcgg
     8941 cgttcctcgg cgcgggcggt tccggcggcg gcgatggtgg cggcgccggt gagggcgccg
     9001 gtcagcaggc gggccatgcg gccctgttcc tcctggtacg tggtgagggc ggcgcggccg
     9061 tcgcggagca gggcgcgcag gatcatcagg aggagcggga cgccgcagac gaacgcggcg
     9121 ccggcccacg ggtcgacgag gaagagcccg gccagcccgc cgaggggggc gaggccggcg
     9181 gcggcagcgg tggcggcggc gacgggggcg gttccggcgt cgagggcgtt ggcggtgagg
     9241 cgggtgggca ggccggtgcc ggtcgtcgcg gcggggggcg cggcgaggaa gccggcgagc
     9301 gcgcggcggc gcagccaggc cgtggtggcg gcgccggtcc ggccgccggt gcgggcgacc
     9361 agggcgtccg tggccacctc ggcggcgatc agcgcgctgc acagcaggac ccagaacccg
     9421 gcgtcggcgc gggcgatgag caggtcgacc gcgcggccga gggtgagggg cagcgtgacg
     9481 gcggcggcgg cgccgagcac ggtggccgcg aggacgaggg ccgcgggccc cctgccccgg
     9541 cgtaccgcct cccgcagcag gcgcccctcg tcgggcggcg ggccgggagt ggcgcgggcc
     9601 cggtcggcgt cggcgggggc ggcggtcatg gctgctccgt tcgggcgggc gggcaggcgg
     9661 gcgggttgtc cgggagcggc gcggaacgcg ggaggtcccg ggcgctgggg cgcccgggac
     9721 caagggctgt cgcacgcgcc cggcccgtga gggccgggcg cgcggcggac agccgggttc
     9781 agctccgcgt cacggggtgc agagggtgac gctcagcgag ctgtactcgc agatgagcag
     9841 cgagatctgg ctgccggtgg cgaggtcgcc caccgcctcc tcctgcgggg tgtccatcgc
     9901 ctggaggtcg agaagcgcca tgacgtactc cttcgtgtcg agcggtcggg cgaccgccac
     9961 ctgggaaaac gagtggtgct ggtggtgcgc gaccctgagg tcagggccgg tctgtgggcc
    10021 gccggagcgg cgggaggaag ggcaggtgcg cggcgggttc gccgtgtgtc gcggccaggg
    10081 cgagcaggac gccggccgtg ccggtggaga ggtccatcga caggcgggtc aactgttctc
    10141 ctgggtaggc gagctgccct tcgtaggtga gcgcgtgcca gtccagcagg gcggtctggc
    10201 gggccaggag ggcggtgcgg gcggcccggt cgacgggggt ggtggtgcgg gccaggtgga
    10261 ggaggagtcc ggccacgccc cggaagaggc cgggctggat gtagaaggcg gagccggtgg
    10321 cccgcaggag ggcggtccgg gcctcctcga aggcggggtc ggggcggtgg gccaggtagt
    10381 cgtcgaggac catcgcgatg cccgcgctcc cggagccgag gtatggcatg gtccgccggg
    10441 cctcggagac gacgagcgag ccgtccggtc ccggcacgca gcggctcagc tcctggcgga
    10501 gggcggtggc ggcggtgtcg agcagggcgg gttcgccggt acgggcgtgg cggcgcaggc
    10561 agagcagggc ggtgccggcc gggccgtgca gcagtccggc cttgccgccg ggggcggcgg
    10621 agcggagtgc ggcggcctcg gcgcggccgg cggccttgcc gagggcgggg tcgtcggcgc
    10681 cgtcggccag gtcgcgcagg gccagggcga cgccgggggc gccggagtgc aggccgggcc
    10741 cgagtgcgtc gaggggttcg gcggcgacca ggtgggcgag gcgcagggcg tcctcacggt
    10801 ggccgaggcg gtccagggtc caggcgatgc cggtgaggcc gtcgtagaag ccggccgggg
    10861 tgcccgaggc gggccggcgg gtggtgcgga tcagccattc ctcggcctcc tcgcagcggg
    10921 cgccgacggt gtgcagggcg tgcaggacgc cggcggcgcc gtagccgtac gactgtccgc
    10981 cggccggggt ggcgaactgg gcgatgtcgc ccgggaagta gcggtcgtcg cggtcggggg
    11041 tggcggaggc gagcagggcg gccaccatcg agtcgcgggc ggcgggccag tcggtggcgc
    11101 tcaccggcgg gcggccacgg ggtgtcgcgg cctccggcct tgccgggccc gcgagttcgg
    11161 tgaccgcctc gtcgaagagg gcacggtcga tgccgtaccg gtcggcggcg aggtcggcga
    11221 ggtgggccgc cttgtcgcgg tcgaggggca gcagggtggt gagcgggacg aagagggcga
    11281 ggcggaggca ggccagggcg taccggtcga cctctgtgcc gcgcaggtgg ggcggggcga
    11341 cgaaggcggg attggcgacg atctgcgggc ggcgctcggc ggccggggtg gcggcctcga
    11401 agtccagcag ggtgacggag agctggtccg gcgccaccat gatgttgttc atgtgcaggt
    11461 cgccgaaggc gatgccccgg gcgtgcagcg cctcgaccgc ctccgtgacg agctggtggg
    11521 tgcgcagggc ccaggcggtg tgctcggcga gggcttcggc ggccggctcg gcggcggaga
    11581 gcgggaagcg gcgggcgaag accgtgttga gcggggtgcc ggggatgaac tccatggcca
    11641 ggaagcggtg ttcgcccacg gtgtgcagtc cgtgcacgcg cgggacgcac gccagccctt
    11701 cgagggcgcg cagggccgcg tactcccgct ccagccgggt gaccgcgtcg gccccgtcgg
    11761 cggcgagccc ggcgtacggc cggccctcct tgagcaccac ggcctcaccg gtctcccggt
    11821 gcgaaccggc gtacaccccg cccccgttgg agaagtgcag ggcgcgttcg acggtgtacg
    11881 ggaggccgtt cgtgccctgg gcggcgcggg cctcggcgtg cgggcgcagg aagtcgggga
    11941 gtgccaccca gtcggggagg cggaaggcgg ggccgcgggt gtccgggacg aggcggcccg
    12001 tcgggtcggc caccgccggg accagggagc cgtcggcggt gcgggtgaag cggggcgcga
    12061 aggcgccgta gcggacgtgg accgggccct cgccccagcg caggtcgctg aggacgaccg
    12121 ggcccgcgct gcccttgagg gcgtccgcga gctcggcggc cagttcgccg caggcggcgg
    12181 tggtggccgg gtagacggtg acgaacttgc cgctgccggc gcggtcggcg tacttggtgt
    12241 tgcggtggag cagcagggcg ggcccggcga ggaacttgaa ggcggtggcg cgctcctggc
    12301 agatcccggc gacggtctcc aggacctgct cggcgttgtc cggcgtcgcg gagacgtgga
    12361 tcttccagcc ctgggcgggg agctggcgcc cggcgggggc gagcgagaac cagtcaccgc
    12421 gctcggcgct ctcccagccc ccgggggcgg gccgcagggc gagggcgtaa cggtggccgt
    12481 cgttgccgtt gccgtcaccc gcacggccgg cccggcgcgg ggtgtcgtag aaccagcggt
    12541 cggcaccgct gtagagcgcg tactccggat tcaccggtcc ccctcgcctt ctgcgttccc
    12601 gtgccgtgct gtgcgtcggt gacgggttcc acactgcccg tggccgggcg gcgccggtaa
    12661 gtaacgcttg tcatcggcga gttgtgggaa acgcatggtc cgaacgggtc atggcggacg
    12721 ggctcggagc gtgctgcggg ggccggtggc tgccggagcg agggcggctc aggagggggt
    12781 cagggcctcc tccagctggt ccaggatctg ctgggcggcg gtgtaaccga tgccctggat
    12841 ccacagctcg tcctcgacct tgtggacggc gccggacttg acggcgtcca gggagcgcca
    12901 gagggcggac ctggtggtcc gcgtctccct ggccttctcc gggtcgccgt aggtggcggt
    12961 gaagaccacg tcggcgtcgg ccaggtcgat cttctcgggg ctcacgtcgt acgagaagcc
    13021 gtcagcggcc ttgtcggtga cggcggggcg gccgaggccg acgtcggcga ggagggtgcc
    13081 gatgtagttc ttcctgccgt agatgcggat gtcggctccc tcgacgaagc ggaccacgtt
    13141 gacctcggtc tccttcgcct tcgccgggcc gccgaccgcc tcggtgacct cggcggtccg
    13201 cttctcgtag gcggcggtgg cgcggtcggc ctccttctgc ttgccgaggg cctcggcgtg
    13261 cagctggaag ttctccttcc aggggtagcc ggtgttctcc gtcatcacgg tggcggcgat
    13321 cttgctgagc tgggcgtagc gggcctcgtc gcggaccttc gaggtgagga tcaggtccgg
    13381 cttgagcgcc gcgatcgcct ccaggttggg ctgggcgatg acgccgacgt tctcgatccc
    13441 ggccagttcc ctctgcggca ggtagcccgc gaacccgccg gcggcgtcgg agcggacggc
    13501 gccgaccggc ttcactccga gggtgagcgc ggagtccagc tcggcggtgt ccaggacgac
    13561 gacccgcttc ggcgcctcgg ggacctccac ctcgcccatc gcggtcttga cggtacgggt
    13621 ggctcccgca tccttgcccg cgtcggcggc ggtctcctcg ccggagccgc aggcggtgag
    13681 ggtgacggcg agcgcgaggg cgccggtggc ggcgaggagc ggacgggcgg tacgtcgggt
    13741 catggcgtgg ccctgctttc ttctcgggtg ggggcagcgg gttccggcgc cggctgccgg
    13801 gcgtcccagg gcgcccccgg gacgacgagc ggggagccgg tgacggggtc ggggacgacg
    13861 acgcactcca ggccgaagat ctcccggacc aggccggcgg tgacgacctc ggcgggggcg
    13921 ccctcggcga cgacgcggcc ctcccggaag gcgatgaggt gatccgcgta gcgggcggcc
    13981 tggttgaggt cgtgcaggac gaggacgacg gtgcggccct gctcgcggtt gaggcggcgg
    14041 accaggtcga ggacctcgac ctggtgggcg aggtcgaggt aggtggtggg ctcgtcgagc
    14101 aggagcaggt cggtctcctg ggcgagggcc atggcgatcc agacgcgctg ccgctggccg
    14161 ccggagaggg cgtccacggg acggtcggcg aggtcggtcg tggcggtgcg ggccatcgcc
    14221 tcggtgaccg cccgctcgtc ctccgccgac cactgctgcc accaccgctg gtgcggctgg
    14281 cggccgcgcg ccaccaggtc ggccacggtg atcgcctccg gtgccaccgg ggtctgcggc
    14341 agcagcccga tccgccgggc gatctgccgg gtgggcagcc gggccagttc cgtgccgtcg
    14401 agcaggacgg cgccgccggc ggggcggagc agccggccga gcgcccgcag ggtggtggac
    14461 ttgccgcagg cgttgggccc gatgatgacg gtgacccggc cgtcggggac gtccaggtcg
    14521 aggccgggga cgacggtgcg gtcctcgtag gcgagggtga ggtctcgggc ggtgaggcgg
    14581 gcggcggggc gggtcatgag gtgcctccgg tggcgcgggg gccgtgtcgg gtgacgagca
    14641 gccagatcag gtacggggcg ccgaccgccg cggtgagcac ccccaccggc agttcggtcg
    14701 gcgcgaagag gcggcgggcc agcaggtcgg cggcgaccac ggtgacggcc ccggccagcg
    14761 cggagcagac cagcgggatc tgcgcggtac gggtcagccg ccgggcgatc tgcggggcga
    14821 ggagcgcgac gaagtcgacg ggcccggccg cgccggtggc gaccgaggcg aggaccacgc
    14881 cgatcaggac gagtccgagg cgggcgcgtc ccaggtgggc gccgagtccc gtcgcggtgg
    14941 cgtcgtccag ggtgacggtg cgctggacgc gggcggccca gaccagcgcg ggcagggcgg
    15001 cgagcagggt ccagccgacg agggcggctt ccggccaggc gcggccgttg agggacccgc
    15061 tcatccacac ctgggcctgc tgggccacgg tctggtcgcc cttggtcagg aagagcgtgg
    15121 tcagcgcccg cagggccacg gcgaaaccga ccccgaccag cacgaaccgg gtggcctgga
    15181 gcccgccccg ccaggcgaag aggtagacga gcagcgccgc gaggagcccg ccgcccaggg
    15241 agatccaggg cagcacggcg tacgaggtga cgccgaaggt cagcgcggcg accgtggcgg
    15301 cgctcgcgcc ctggctgaca ccgatcaggt ccgggctggc cagcgggttc cgggcgacgg
    15361 tctggatgag cgcgcccgcg atcccgaacg ccgccccgac gtacagcccc gccaccatcc
    15421 gcggcagccg cagctccccc accaccagcg tgtccggcga gggacgcccc agcagcacgt
    15481 cgaccaccga cccgggcgcg acgaagctct cgcccacact caggtacgcc acacagacca
    15541 cggccagcac ggccgccagg acggcgccgg tcgcgaccgc ccgcacgggg acgagaagac
    15601 tgacggcccc cagccgtacg gggacgtacc cggcggggcg tacgcgggcg gggaccggcc
    15661 ccgccttcag cacctgccgc tcacccggtc accaccctgc cccggaccag cgccaccagg
    15721 aagggcacgc cgatcagcgc cgtcatgacc ccggcgggga cctcgcccgg cgggaagagg
    15781 acgcggccga cggtgtcgga ggcgaggagc atcacggggc cggtcagggc ggccagcggg
    15841 aggacccagc ggtggtcgcc gccggccagg tggcggacga ggtgcgggac ggcgaggccg
    15901 acgaaggcga ccggcccggc ggcggccacc ccgaccccgg tcagcacggc ggctccggcc
    15961 cccgcggtga tccgtacggc cccgacccgc tgccccagcc ccttcgccac gtcctccccc
    16021 agcgccagcg cgtccagccc ccgcgccgag gacgccacca gcgccagccc caccagcagg
    16081 aacggccaca cctgcacggc cacctcggcg tcccgcccct ggagcgcgcc gacgttccag
    16141 aagcggaact cgtccagggc gctggaactg gtggtcagca cggcggtggt gaccgagacc
    16201 agcagggcgt tgaccgcggc gccgctcagc gccagcttga ccggggtcgc gccgccccgg
    16261 ccgcccgccg cgaccgcgta cacggcgacc gccgcgagcc ccgcgcccgc gaaggcgaac
    16321 cagacgtacc cggccagggt gtgcaccccc gcgaaggcga tggccaggac gaccccgacc
    16381 gaggcgccct ggctgatgcc gagaatgccc gggtccgcga tcggattacg ggtgatgccc
    16441 tgcagggcgg tcccggcgac ggcgagggcg gcgccgacca tcacgccgat cagcgtgcgc
    16501 ggcagccgca tctcccggac cacctcggcg tccggacccg tggccccctg gaacagggcc
    16561 tccacgaccg tgccgggggc caccgtacga gcgccgacag ccaggctgag gacgaccgcg
    16621 accagcagcg ccaccagggc cgccaccgtc caggccgccc ggtgtacggc gctgtcccgg
    16681 cggggccggg aggctggggg cggtgccttc gccaggggcg gggcggcggg cggtgcgggg
    16741 ggcatcgggt cctttccggt ccgggctgtc tccgggccgg cggccgggag cggacatgac
    16801 ggcacaccgc cccaattgcc cgttccgcga cggcacttag gcttggctaa gtgtacggcc
    16861 gtcggggctg cacaatggag ggatgcccga gcacctcacc tcccccgccg cgcccactcc
    16921 ctccggcccc gccgtaccgg ccgcacgtcc ggctccgggc ggggccgggc ccgtcgtcgg
    16981 gttcgacctc gacatgacgc tgatcgactc ccggccgggg atcggcgcgg cctatcgcgt
    17041 actcgccgcc gagaccggcg tccccatcga cgtcgacctg gtcgtctccc ggctcgggcc
    17101 gccgctggag accgagctgg cctgctggtt cccggccgag caggtccccg ccgccgccgc
    17161 gcgctaccgc gaggtctacc cgtccaccgc ggtagccccc tcgctcgccc tgcccggggc
    17221 cgcgcaggcg ctggaggccg tacgggccca cggtggacgc tcgctggtcg tcaccgccaa
    17281 gaacgaggag cacgcgcggc tccacctgga ccacctcggc ctccgggccg agctcgtcgt
    17341 gggcagcctc tgggccgagg ccaagggggg tgcgctgcgc gcacaggggg ccaccgtgta
    17401 cgtcggggac cacgtcggcg acgtccgcgg cgcccaggcc gccggggcct tctccgtggc
    17461 cgtcgccacc gggggctgca cccccgacga gctccgggcc gccggcgccg acgtcgtcct
    17521 ccccgacctg gccgccttcc ccgcctggct ggcggagttc gcccgctgac ccgcctcatg
    17581 cgccggctgg gccgctcttc ggctggaccc ggtttgcccc acaccggtca aggacggcct
    17641 caaacgccgg ccgggccata gggtttcgcg gtgcgttcgc cgtcctggcc gggcggggcc
    17701 gcaccgcccc gaaggttccc gtcggagcgg ggcggcccgg ccggaccggc ggcacacacc
    17761 ccgtcgaggt cccgggccag ctcccggaag tcacgccagt cctcgggctc gaccccgcgc
    17821 agccgcagct tctcgccggc ccagacgtcc gccacgacgc ccccggctcc gcatccccga
    17881 cgggcactcg ggaccggccc gcacgacccc gccacggtac cggcgccccg ccccgcccgg
    17941 gccctgcgta ccggcggccc ggcccgcccg cgtaccgtgc aacccccgcg cccaggtcgg
    18001 ccgcgccccg aacggggtag gcaccccccg acccgtaggg caccgggtgc cgcgaggagg
    18061 aacgatgaag caaccggctc ggacagcggg cggggccgtg gccgaggagg cgcggccggt
    18121 ggagggtgtc gagggggacg agccagggcg ggcggcagag tggtgggtgg cgttgcggcg
    18181 gacgccgggg gcgttctggc gggacgacgt ctcggacttc gcggcggcgc tgacctatta
    18241 cgcgatcctc gccgtgctgc cggcgctgct ggtggtcgtg atcgctttcg ggctggtcag
    18301 tccggacacg gcggagcggt tcgtgggcca ggtgacggcg tgggcgccgg gcggctcggg
    18361 ggcctcgttg cgcgaggtgc tgacgcgggt ggtgcgggtc gactcgaccg cctggacact
    18421 gctggtgacc ggcggcgcga gcgcgctctg gtcggcctcc agctacctgg cggtctcgcg
    18481 gcgcgcgctg caccgcatgt acggggtacg ggaccggcgt tcgccgtggg gcaaggcgca
    18541 ccggatcgtg gcgacggccc tggccctgct gtcgctgctg ctggtcagtt cgctgctgct
    18601 gatgctgacc gagccggtgg ccgagtcgat cgggcggctg ctggggctgg acgccggggt
    18661 ggcgtgggcg tggagcgtgg tgcgctggcc gttgctgctc tgcctggtgg cctgtctggt
    18721 cgtggtcgtc ttccggaacg gcccggcggc cgcccgccgc cgcgcccaca gcatccccgg
    18781 cggcgtcctc gccgcgacgc tctggctgac cgcgtcggcg gggctcgcgc tgtacgcctc
    18841 ggtgctcagt acgtacagcc gcctctacgg ctcgctcgcg gggatcgtcg tcttcctggt
    18901 gtggctgtgg ctctccaacg tcgcgctgct gctcggcgcc cagttcacgg cggagttgtg
    18961 ccgcgcggag gggggcccgg gcgcaccggc ctgccgcccc gggccggtcg agggcatggc
    19021 cgccgaggac gtgccggccg gcaccgacgc cgcccaggag cacgggcgcg cccccaccgg
    19081 cgcgtgatcc ccttccgcct ttcgccctgg cgggggcgtc ccgcaccgca tgagggcaag
    19141 gcgggtgatt ccccgcagag ggtgcataca tcccgccagg agctggcctg aactggctgc
    19201 ttgacatatg acacatggtc agttgggccc tatccatgac tccctggcga ccgttacttt
    19261 acaaagtgtg attactgaac gagagattcc gctccgccac agctccatct ccgcctccgc
    19321 ttccgtcgcc gacgacctgc tcttcgcgac acgcggcgaa gagcacctgc gctggcggga
    19381 gctattcagc acggaggagt tcggccaccg ggacttgccc caccgggaaa gggtggagtt
    19441 gtcctatcgg cgcttgcgta ccgtcgccgc cgcgataccc gatccacgcg cgctcgccct
    19501 gagcgcgccg gcgctgaccg cgctccacga gtgggcgggc ccggccgatc ccgggatggc
    19561 cacgctggcc tccatccact acaacctctt cctgggcagc ctcctcgacc acgatcacgc
    19621 ggagcgggac ctggggccgt ggctgcggat ggaccggatc ggcacgttcc tgtgcaccga
    19681 ggccgagcac ggcaacgacg cggtgaacat ggagacgacc gccgagtacg accgcgcctc
    19741 tcgtcagttc gtcctcaaca ccccgggccc gggggcggcc aagtggatgc ccaacacctc
    19801 gctgaccggc ggcccgaagg acgccgtggt ggcggcccgg ctgctggtcg acggccgcga
    19861 cctgggcatc ttcctcttcc tcaccccgct cagcgacgag cgcggccacc tgccgggcgt
    19921 cagcgtcgag cggctgccgc acacgtccgg cgcgcccgtg gaccactgcg ccacccgctt
    19981 ccaccacgtg cggctgccgc acagcgcgat gctccagggc gaccacgggc ggctgagtcc
    20041 ggagggcgag ttcgagagca cgctcgggag cccccgtatc cgcttcctgc gctccatcgg
    20101 ccgggtgtcg atgggcaagc tctgcatgtc cggttacagc ctgggcgcca cccggcaggc
    20161 gatcgcggtc gccgtgcggc acggctccac gcggctgacc tccggcatga ccaaggggcg
    20221 cagggtcccg ctgatggccc accgcagcca ccacgagccg ctgctcgacg cgctcgccac
    20281 cacgtacgcg gcgacgctgc tgcaccgctc ggtggtacgc cagtgggagg tggccgagga
    20341 ggccgagcgc gaggaggtcg accggctggt cgcggtgacc aaggggtgga tcacctgggc
    20401 ggcccgggag accatgacga cctgccgtga gcggtgcggc gccaaggggc tgctgctgac
    20461 gcagggcatc gcgggccagc tcgccgccaa cgagggcacc atcaccgccg agggcgacaa
    20521 caaggtcatc tgggtcaagg ccgccggtga gctgctgatg ggtgggttca ccccgaagcc
    20581 gcccagcgag accgcgcccg agcagcggtc cctgcgggac ggcacgcacc tccaggacct
    20641 gatggcggac gtggagcgga tctggcacga gcgggcccgg acccggctgc gctcgggcgg
    20701 cgtacgcggc aacccgatgg cccgctggaa cggcgccgtc accccggcgc tggagctggt
    20761 cgccgcccac gcgcaccggc tggccgggga ggcgctgctg gagggcaccg accgggtcag
    20821 cgccgacgag gccgagcgca tccgcgacct gcaccggctc ttcgcgctgc gccaggtggc
    20881 ggcgcacagc ggggagttgc tggccggaga gcggctgacg gcggagcagg tgcggcggct
    20941 cccggacgag gtcgagcggg tcgtggcgga cctggagccc cacatcctcg ccctgacaga
    21001 acgtttcttc gtaccggaga acctgcccgg cagcgacccc gccggcctgg tcgaggccgc
    21061 gcccgaggcc ctcgccgccg gcacggaggc ccgtaccggc ggactccggg agagcgagcc
    21121 ggacgcggca tgacgggctg aggcgaacga aggcgtgacg cgggacggcc cgccgcgcgt
    21181 gggcacgacg gaccgtcctt gcgtctcccg tcctccgggc ggcacaccgg ccggaggcgt
    21241 ttgggtcaga cccggaagat gtcaaggaag gagctccaga agcccttcct gcgaccgccg
    21301 ccgtccgagg aggccggggc ggtgtgctgc ggctgcgggg tggcgggtgc cacctgctgc
    21361 tgcgggacgc cccggctctg gagggccgcg gccatccggg tggccggagt cgggctgaag
    21421 gcgaccggca gcgagaccag agcccggtgg aacgggccgg gccgccactg cagttcctcc
    21481 tccgggacgc cgagcgtcag gtccggcagg gcgttgagga tcttctcgac cgcggtgacc
    21541 gcgatgacct gcgccgggtc cttggccggg caggcgtgcg agcccgcgcc ccaggcgagg
    21601 tgggcgccgc gtcccgcgct gcggcgggcc tcggcgaggg cggggtcgct gttggccccg
    21661 gcgaaggaga tcaggacggg gctgccggcg ggcgcgatga caccgttgcc gaagtccgtg
    21721 tcctgggccg ggtagtgggc ggcgtagttg gcgatcgggg tgcggtgcca caggacgtgg
    21781 tcgaccgcct cctcgaccat catcccggcg ccccggccgc ccgcgccgcc ggagagcagt
    21841 tccagcaggg cgttgccgat gaggttgcgc tccggctcga tgccggcgcc catcaacatc
    21901 accagctggt ccttcagctc ctcgtcggtc agcccggccg ggtgctggat gagccaggag
    21961 atgacgtcgt cggccggctc gcggcgcttg atcgcgatga gctgcatcag gcaggcgtcg
    22021 aggcgggcct tggtccgcac cgggtccttg ccgtcgaaca tcgccgacat ctcggtggtg
    22081 agggtgtcgc cgatctcggc cgggcagccg aagagcttgt tgaacagcag cagcgggagc
    22141 agcttggcgt actccgcgag gaggtcggcg cggccgcgct cgctgaactg gtcgatgagg
    22201 tagtcggcga tcggctccac gtcacggcgg atgcgcgtga tgttgagctt ggcgaggctg
    22261 tccgtgaccg ccttgcgcag ccgcaggtgg acggcgccgt cggtgaacag ggcgttcggc
    22321 cggtacgcca tcatcggcag gaccgggctg tccatcggga cgcggccctc gttcagggcc
    22381 gcccagcggc gggcgtcgcg ggggaagctc gtcgggttct ggagaacgcg cagcgccgtc
    22441 tcgtacccca cgaccagcgt cgcgtcgact ccgggggcca gctcgaccgg gccggccggg
    22501 ccctgctcgc gcagctgctc gtagaccgcc tgggggtcgg cggcgaagtt ggcgtcgtgc
    22561 atcgggcatc tgcc
//
