LOCUS       NZ_CP106650            22286 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Streptomyces sp. GBA 94-10 4N24 strain GBA 94-10 chromosome,
            complete genome.
ACCESSION   NZ_CP106650
VERSION     NZ_CP106650.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GBA 94-10 4N24
  ORGANISM  Streptomyces sp. GBA 94-10 4N24
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7025021)
  AUTHORS   Ian,E., Malko,D.B., Sekurova,O.N., Bredholt,H., Ruckert,C.,
            Borisova,M.E., Albersmeier,A., Kalinowski,J., Gelfand,M.S. and
            Zotchev,S.B.
  TITLE     Genomics of sponge-associated Streptomyces spp. closely related to
            Streptomyces albus J1074: insights into marine adaptation and
            secondary metabolite biosynthesis potential
  JOURNAL   PLoS One 9 (5), e96719 (2014)
   PUBMED   24819608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025021)
  AUTHORS   Ruckert,C., Busche,T. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-SEP-2022) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
REFERENCE   3  (bases 1 to 7025021)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-NOV-2021
            Assembly Method                   :: flye v. 2.9-b1768
            Assembly Name                     :: GB94_v2
            Genome Coverage                   :: 229.4x
            Sequencing Technology :: Illumina MiSeq;Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495635.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 06:31:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,298
            CDSs (total)                      :: 6,204
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 100 of 216
            Pseudo Genes (incomplete)         :: 164 of 216
            Pseudo Genes (internal stop)      :: 24 of 216
            Pseudo Genes (multiple problems)  :: 67 of 216
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:13:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1672180
            Orig. end                         :: 1694466
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106650.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Wittmann Lab, Saarland
            University, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22286
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="10"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22286
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22286
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12286](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12286
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(276..491)
                     /locus_tag="B591_RS06985"
                     /old_locus_tag="B591_06965"
     CDS             complement(276..491)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015507043.1"
                     /locus_tag="B591_RS06985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06965"
                     /product="acyl-CoA carboxylase subunit epsilon"
                     /protein_id="WP_023416822.1"
                     /transl_table=11
                     /translation="MATPTVPATPEQFLRVEKGHAEPEELAAITALLMARAAAQPAPAA
                     RRGRDRAGWRRLERTPGFRAPHSWQG"
     gene            complement(530..2122)
                     /locus_tag="B591_RS06990"
                     /old_locus_tag="B591_06970"
     CDS             complement(530..2122)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266768.1"
                     /locus_tag="B591_RS06990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06970"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_037787031.1"
                     /transl_table=11
                     /translation="MTVLDETAESGSEPADARGRVAELHALRQRAEQGPGEKATAAQHA
                     KGKLTARERIALLLDEGSFREVEQLRRHRATGFGLEQKRPHTDGVITGWGTVEGRTVFV
                     YAHDFRIFGGALGEAHATKIHKIMDMAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIF
                     QRNTKASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVRAVTGEEI
                     SQNGLGGADVHAETSGVCHFAYDDEETCLAEVRYLLSLLPQNNRENPPAAEATDPAGRR
                     GDALLDLVPADGNRPYDMAKVIEELVDDGDCLEVHERWARNIICALARLDGQVVGIVAN
                     QPQSLAGVLDIEASEKAARFVQMCDAFNIPIVTLLDVPGFLPGVDQEHGGIIRHGAKLL
                     YAYCNATVPRISLILRKAYGGAYIVMDSQSIGADLTYAWPTNEIAVMGAEGAANVIFRR
                     QIAGADDPEAMRARMVKEYKAELMHPYYAAERGLVDDVIDPAETRQVLIDSLAMLRTKH
                     ADLPSRKHGNPPQ"
     gene            complement(2418..2957)
                     /locus_tag="B591_RS06995"
                     /old_locus_tag="B591_06975"
     CDS             complement(2418..2957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470926.1"
                     /locus_tag="B591_RS06995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06975"
                     /product="hypothetical protein"
                     /protein_id="WP_023416824.1"
                     /transl_table=11
                     /translation="MKIRSALSALALVAGAGFGVIGTATAATAAPAPTSTTAEAGAAAT
                     KITHAQATSRFSSSGITWSSSGGCSNRNVSTCTSFDQLNLATAQGAQTLKSASGCAINI
                     TGGTETGHAGGTYSHWNGYKLDFSKSTCLNNYVTGTFTYIGQRGDGAAQYQSGSGNVYA
                     NEGNHWDVTYYNCGGC"
     gene            3275..3868
                     /locus_tag="B591_RS07000"
                     /old_locus_tag="B591_06980"
     CDS             3275..3868
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414932.1"
                     /locus_tag="B591_RS07000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06980"
                     /product="YceI family protein"
                     /protein_id="WP_023421593.1"
                     /transl_table=11
                     /translation="MGIFGRKNETTDTTVSPDLAALTGTYTLDPTHTTIGFVARHAMVT
                     NVKGGFGDFTGTLTLDGSDPSNSTAEIDVAMDSVDTGNADRDGHLKNADFFKTDEFPKM
                     TFRSTEAEALGGDDYRITGDLTILGTTRPLSIDLEFNGSATDPFGNERVGFEGTASILR
                     SEWGLTWNAALETGGVLVSDKIKLVFDISAIKNA"
     gene            complement(4342..4707)
                     /locus_tag="B591_RS07005"
                     /old_locus_tag="B591_06990"
     CDS             complement(4342..4707)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010641993.1"
                     /locus_tag="B591_RS07005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06990"
                     /product="hypothetical protein"
                     /protein_id="WP_037787032.1"
                     /transl_table=11
                     /translation="MSENVYVGNAPEEAALDAGWIMGHFKAPDDPRHNEAVEIKWGVHE
                     AGERRAAWVRGEERQALLVLVSGRFRMEFPERDVVLSEQGQYVIWGKGVDHSWEAEEPS
                     VVMTVRWPSVPGYRVSP"
     gene            4835..5317
                     /locus_tag="B591_RS07010"
                     /old_locus_tag="B591_06995"
     CDS             4835..5317
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-154). E-value: 4e-20.
                     Score: 64.6. Matches aSDomain:
                     nrpspksdomains_B591_RS07010_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414939.1"
                     /locus_tag="B591_RS07010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_06995"
                     /product="SRPBCC family protein"
                     /protein_id="WP_026048269.1"
                     /transl_table=11
                     /translation="MRSTAEVSVAAVIEAEPKAVYERVADVASMGRWSPECVRTAAGVG
                     PAPVGAEFKGTNKGPSGRSWSTRCRVMVARSGERFTFRVRFWGMPVATWDYRFRPVGDG
                     TATEVTETAVDQRNRLLWFLGSAVSGVWDRSAHNAETMRETLERLRETLEAERRAG"
     aSDomain        4847..5296
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS07010_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.00E-20"
                     /label="B591_RS07010_Polyketide_cyc2.1"
                     /locus_tag="B591_RS07010"
                     /protein_end="154"
                     /protein_start="4"
                     /score="64.6"
                     /tool="antismash"
                     /translation="AEVSVAAVIEAEPKAVYERVADVASMGRWSPECVRTAAGVGPAPV
                     GAEFKGTNKGPSGRSWSTRCRVMVARSGERFTFRVRFWGMPVATWDYRFRPVGDGTATE
                     VTETAVDQRNRLLWFLGSAVSGVWDRSAHNAETMRETLERLRETLE"
     gene            5365..6045
                     /locus_tag="B591_RS07015"
                     /old_locus_tag="B591_07000"
     CDS             5365..6045
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414941.1"
                     /locus_tag="B591_RS07015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07000"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_023416828.1"
                     /transl_table=11
                     /translation="MSDHQTAGADGEEARARAAVRDAWARIDAWMRAHAPDSYEVLAPP
                     ADPAAVEAAQAELDVRFPADLLASLACHDGLRHWANCLPLRPPLPVADIVDHWQMCVEI
                     DEDNRADEDEPEPEGEEPWWHPQWIPWAQSDGDAQIIDMRPGPGQGRLGMAYHDDCGVF
                     GDGWPSLATYLTEVADVLEKGGAVGGTWAPYLTTAGELWWSLKGETQLNGEPLTPAPAP
                     SAGS"
     gene            complement(6317..7129)
                     /locus_tag="B591_RS07020"
                     /old_locus_tag="B591_07005"
     CDS             complement(6317..7129)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642004.1"
                     /locus_tag="B591_RS07020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07005"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_023421594.1"
                     /transl_table=11
                     /translation="MPDTPDAEGLTVGQASARLDVTVRALHHWDEIGLARPSLRTPAGY
                     RLYTAPDLERLHRIVVYRELGLGLDKIRAVLDDAATDVPAALRAQRAQIAARIDRLQQL
                     GAGLDRMIDAHEHGLLLTAEQQAAIFGPGWSPDGPVQARQRYGDTTQWRQYAERSASRT
                     PEEWQAVADDVARLERALGEAMDSGVTPGSPEANHLVERHREVFASYFPLSRQMQVCLG
                     RMYEGDPGFAAHYDAVRPGLATWFRQLVDAAARAHGIDPDTAIWDEDR"
     gene            complement(7122..7664)
                     /locus_tag="B591_RS07025"
                     /old_locus_tag="B591_07010"
     CDS             complement(7122..7664)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642006.1"
                     /locus_tag="B591_RS07025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07010"
                     /product="VOC family protein"
                     /protein_id="WP_023416830.1"
                     /transl_table=11
                     /translation="MSDDTYYNAFEISPVPAPGPDAVPPEPFRGIYGMPAFVNIPTTDL
                     AASVEFWTRGLGFFELFSIPGTLVHLRRWAFQDVLLVAAESVPEQPPAMSFSFSGVLSQ
                     VDSLVEACRALRPDAVEGPRDTPWNTRDVEVITPENARIVFTAAKPFDPDTQEARNLEA
                     IGITPPGETPGDNERHA"
     gene            7802..8197
                     /locus_tag="B591_RS07030"
                     /old_locus_tag="B591_07015"
     CDS             7802..8197
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414948.1"
                     /locus_tag="B591_RS07030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07015"
                     /product="hypothetical protein"
                     /protein_id="WP_255219938.1"
                     /transl_table=11
                     /translation="MPRKPPGRVRTGLPRPRRPYEKSPVIDGLSGGTLAELARLERTRN
                     HLWPGAVSEAARAWAGHVRLPRGRTWPHPGHGPCYCCPDPWESRELLDQVARALSRRGA
                     RELRRVLAAHDQLWDPAPRTYRGEGPW"
     gene            complement(8297..8722)
                     /locus_tag="B591_RS07035"
                     /old_locus_tag="B591_07020"
     CDS             complement(8297..8722)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414951.1"
                     /locus_tag="B591_RS07035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07020"
                     /product="ATP-binding protein"
                     /protein_id="WP_023416832.1"
                     /transl_table=11
                     /translation="MKTETGLPAHCERFYRRERRSVPAARDFTAAVLDEWDARVRRDDV
                     LLCVSELATNALLHGVPPGRGFRLFVLRADDGGVRVEVHDSGDGRPATRAPGGEAESGR
                     GLLLVSALADDWGVGERDPGKSVWCSFRPVGVGCTGK"
     gene            8835..9653
                     /locus_tag="B591_RS07040"
                     /old_locus_tag="B591_07025"
     CDS             8835..9653
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470914.1"
                     /locus_tag="B591_RS07040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07025"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_023416833.1"
                     /transl_table=11
                     /translation="MQQRKKSSKKVTSWEVVGAQLAEFRRSAGLTQPQLAGTAKVGEDT
                     LASIEQGRRRLKADLAELLDTILNTKRALATAVSKIPDRERYPAFAQEFVEHEQEALTL
                     LSYQNHVIPGLLQTPEYVEQIYANLFPPLSSEATEVAIRARLDRQNLLHREPPPVMNFI
                     IEESVFQRHMGNPDGMRRQIRHLRECADLPFIGIQVMLTATDAHAGLAGPLVLLETPDH
                     DHLAYAEGQHNGFLMDDPDEVSAYQQRYGMLRSQALSPQRTKSLLNTLLE"
     gene            9655..9921
                     /locus_tag="B591_RS07045"
                     /old_locus_tag="B591_07030"
     CDS             9655..9921
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470913.1"
                     /locus_tag="B591_RS07045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07030"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_023416834.1"
                     /transl_table=11
                     /translation="MTSEAPSVRNLGWFKSSYSSNAGGDCVEVAYNWRKSSYSGDFQDA
                     CVEVAAHPTAVHVRDSKVPAGPTLDVTPAAWAAFVHATAGPLV"
     gene            10001..12286
                     /locus_tag="B591_RS07050"
                     /old_locus_tag="B591_07035"
     CDS             10001..12286
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414954.1"
                     /locus_tag="B591_RS07050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07035"
                     /product="terpene synthase family protein"
                     /protein_id="WP_037787781.1"
                     /sec_met_domain="T1TS (E-value: 8.3e-82, bitscore: 274.3,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFVLPDFYVPYPARLNPHLEEARAHARVWADEMGMLEGSGIW
                     DLADLEAHDYALLCAYTHPDCDGPALSLVTDWYVWVFFFDDHFLELFKRTQDREGAKAY
                     LERLPAFMPMDLAGGFPEPQNPVEAGLADLWARTVPAMSEDWRRRFALSTENLLNESMW
                     ELSNINAGRVSNPLEYIEMRRKVGGAPWSAGLIEYAAQAEVPEAVAYSRPLRVLTDAFS
                     DGVHLRNDLFSYQREVEEEGELSNGVLVLERFLECTTQEAAEAVNDLLTSRLQQFENTA
                     LTELGPLFADKGLNPAESASVLAYVKGLQDWQSGGHEWHMRSSRYMNEGAVDGEAAPPT
                     PGGSPGALAAALLGGTLGTSALNVGAFFGRPARQRARSFSHVPYQRTGASLLPDFKLPF
                     PTRLSPALEQSRVDTVEWAHRMGLLVPQPGVPGSDVWDEEALAGYDFPLCAAGLHPEAD
                     LEELNLASEWLTWGTYGDDYYPAVFGRTRNFAGAKLCTDRLRDFMPVEQPSAGPVPTSA
                     LERSLADLWVRTASAMPEKARREFRKTIEVMLDSWVWELDNQAIGRIPDPIDYMEMRRA
                     TFGSDLTMSLCRLRHGNIVPEEVYRSGTIQAMEKAVSDYGALINDVFSYQKEVEFEGEI
                     HNAVLVTQNFFDCDYPTGLAYVDALMNARLEQFEHIVAHELPVLYEDFQLDGAARKVLD
                     GYVRQLENWLSAILTWHRGCKRYKEEDLSHHSPGVRRVIEAAPRGIGPNGLGASTLGTA
                     AARVFAAG"
     gene            complement(12322..13695)
                     /locus_tag="B591_RS07055"
                     /old_locus_tag="B591_07040"
     CDS             complement(12322..13695)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642015.1"
                     /locus_tag="B591_RS07055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07040"
                     /product="heme exporter protein CcmD"
                     /protein_id="WP_023416836.1"
                     /transl_table=11
                     /translation="MLGAAGATAAPAVAAPDQGRPAAVAPVRAAPQAPAAATVSEVAKA
                     WRDGPVFVDPDVSDQLSDADARDLSQEIQDSDKAIFVAVLPATFTDDVDQTMNDLRGDT
                     GITGLYVLRIGDDLHVRADESVLSRQAVQNLESRFQDTTPAGEQLTGLVGNATQNMGGR
                     APTSWSSQDSVSGATWLGLGIAVVVVGGAAYTLTRRRKIRREQAQQEALAKLRVVVDED
                     ITAFGEELERLDFRPLEPGATDEMRGDYERGLDAYENAKSLMDHAQKPEDVREVTKALE
                     DGRFALAVLDARRSGRELPVRRPPCFFDPRHGLSVADVTWAPPGGAPREVPVCAADQAR
                     LERGEDPDIRTVESDAGGRRPYWEAGPAYGPWAGGYFGGGILPGILVGTMLGHMMMSPA
                     YAADYGSAEGFGDGGAGGGYEGGDASGSDFDPGDFGGGGGFGDGGGFGGGGGDFGGGF"
     gene            complement(13854..15623)
                     /gene="cimA"
                     /locus_tag="B591_RS07060"
                     /old_locus_tag="B591_07045"
     CDS             complement(13854..15623)
                     /EC_number="2.3.3.21"
                     /GO_function="GO:0043714 - (R)-citramalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009097 - isoleucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cimA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470910.1"
                     /locus_tag="B591_RS07060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07045"
                     /product="citramalate synthase"
                     /protein_id="WP_023416837.1"
                     /sec_met_domain="HMGL-like (E-value: 3.1e-44, bitscore:
                     150.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSQATPEEPAERAPSAATKPQVARDVRGGDGARPATAGTPASAT
                     SSAAVDAAVERPLHIFDTTLRDGAQREGINLSVADKLTIARHLDDFGVGFIEGGWPGAN
                     PRDTEFFARAREEITFRHAQLVAFGATRRAGGSAADDLQVKALLDSGAPVVTLVAKAHD
                     RHVELALRTTLDENLEMVRDTVSHLRAQGRRVFVDCEHFFDGYAANPAYAKAVVRAASE
                     AGADVVVLCDTNGGMLPAQIQAVTATVLADTGARLGIHAQDDTGCAVANTLAAVDAGAT
                     HVQCTANGYGERVGNANLFPVVAALELKYGRTVLPEGALAEMTRISHAIAEVVNLTPST
                     HQPYVGVSAFAHKAGLHASAIKVDPDLYQHIDPELVGNRIRMLVSDMAGRASVELKGKE
                     LGIDLGDDRALVGRVVERVKERELAGYSYEAADASFELLLRDELRRGTDGAGDAAPSRF
                     FRVESWRAITENRPDGIHANEATVKLWAKGERLLATAEGNGPVNALDRALRVALERIYP
                     ELAKFALRDYKVRILEGRSGTDSTTRVLISTGDGDAEWSTVGVAENVIAASWHALADAY
                     TYGLLRAGVEPAE"
     misc_feature    15970..15984
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            complement(16162..17241)
                     /locus_tag="B591_RS07065"
                     /old_locus_tag="B591_07050"
     CDS             complement(16162..17241)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008414969.1"
                     /locus_tag="B591_RS07065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07050"
                     /product="agmatine/peptidylarginine deiminase"
                     /protein_id="WP_023416838.1"
                     /transl_table=11
                     /translation="MPDAPAPSLRGTVPPGFRMPPEWAPHLRTWMAWPGPNPTFATETA
                     LASAERAWAEVARTVRRFEPVTVLAGPGRAEGARALLGPGVDVLERPLDDAWMRDIGPT
                     FVTRADDGTRAALDWTFNGWGAQEWARWEHDAKIGGEVAALAGVTAYRTGLVNEGGGLH
                     VDGEGTVLLTETVQLDPDRNPGLSRAEAEAEIHAGLGTSKAVWLPRGLTGDYGRFGTRG
                     HVDIVAAFARPGVVVAHTQPDPAHPDHEVCKEITGVLRAARDAAGRPLEVVEVPAPTVL
                     EVDGEWADYSYINHYLCNGGVVLCAFDDPRDAEAAALFRRLFPDRTVVPVDARPVFAAG
                     GGIHCITQQEPAPARGARG"
     gene            complement(17250..19052)
                     /locus_tag="B591_RS07070"
                     /old_locus_tag="B591_07055"
     CDS             complement(17250..19052)
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_process="GO:0043419 - urea catabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018470907.1"
                     /locus_tag="B591_RS07070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07055"
                     /product="urease subunit alpha"
                     /protein_id="WP_023421595.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.3e-45, bitscore:
                     154.6, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDPTGRALPEGLTPRPRAFPHPARTPHGRRTAPDEAARGSDPYA
                     YAAVHGPRTGDRVRLGDTGLTVRVEADAQRPGDEFLAGFGKTARDGLHLRAAAVRDTCD
                     LVISNVLVIDAVLGIRKVSIGVREGRIHAVGRAGNPDTLDGVDVVVGTGTTIVSGEGLI
                     ATAGAIDTHVHLLSPRVMEASLASGVTTIIGQEFGPVWGVGVNSPWALRHAFAAFDAWP
                     VNIGFLARGSSSHAAPLVEALAEGGACGFKVHEDMGAHSRALDTALRVAEEYDVQVALH
                     SDGLNECLSVEDTLQVLDGRTIHAFHIEGCGGGHVPNVLRMAGVPHVIGSSTNPTLPFG
                     RDAVAEHHGMIVSVHDLKPELPGDAAMARDRIRESTMGAEDVLHDLGAIGITSSDAQGM
                     GRAGETIRRTLQLAAKMKRERGPLDGDGEGDDNARVLRYLAKLTVNPARAHGLSHEVGS
                     LEPGKLADIVLWRPEYFGAKPQLVLKSGFPAYGVTGDPNAATDTSEPLVLGPQFGAHGA
                     AAAELSVAFVAGAAVGLGADALPTRRRRVPVRGTRNIGPADLLLNSRTGQVDVDARTGL
                     VTLDGHPVRSGPADSVSLNRLYFL"
     gene            complement(19049..19804)
                     /gene="ureA"
                     /locus_tag="B591_RS07075"
                     /old_locus_tag="B591_07060"
     CDS             complement(19049..19804)
                     /EC_number="3.5.1.5"
                     /GO_function="GO:0009039 - urease activity [Evidence IEA]"
                     /GO_process="GO:0019627 - urea metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ureA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010642020.1"
                     /locus_tag="B591_RS07075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07060"
                     /product="urease subunit gamma"
                     /protein_id="WP_023421596.1"
                     /transl_table=11
                     /translation="MRLTPTERDRLLIFNAAQLARARQARGLRLNVPEATALISDTVCE
                     AARDGARLAEAVAVGRAVLGPDDVLPGVADVLTEIQVEAVFEDGTRLAVLADPIGGGHT
                     GDQAPGALLPGTPHAGPGPVLALRVTNTATVPVSVTSHFHFFEANPRLSFDRAAAYGMR
                     LAVPAGSSLRFSPGETREAGLVPIGGARVVTGFAGLVDGPLDAPGARAEALRRAAACGY
                     LGAGAPGAEPAPPGATPVLPGTPAPETDA"
     gene            complement(20127..21215)
                     /locus_tag="B591_RS07080"
                     /old_locus_tag="B591_07065"
     CDS             complement(20127..21215)
                     /EC_number="2.6.1.42"
                     /GO_function="GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_4 (90-343). E-value: 4.3e-28.
                     Score: 90.6. Matches aSDomain:
                     nrpspksdomains_B591_RS07080_Aminotran_4.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657639.1"
                     /locus_tag="B591_RS07080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_07065"
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="WP_023421597.1"
                     /transl_table=11
                     /translation="MTTPTIELKPSAHPLPEAEREAILARPGFGRHFTDHMVTVKWTEG
                     RGWHDGQLVPYGPLSLDPATNVLHYAQEIFEGLKAYRRPDGSVASFRPDANARRFQASA
                     RRLAMPELPVETFIEACDLLVAQDKAWVPPHGGEESLYLRPFMIATEVGLGVRPANEYL
                     FVVIASPAGAYFPGGVKPVSIWLSENRVRAVPGGVGDAKTGGNYAASLLAQAEAAAEGC
                     DQVAYLDAVEHKWVEELGGMNLCFVYGDRLVTPTLTGSLLAGVTRDTLLSLAADLGCRA
                     EEGRVSIDQWREDSRSGALTEVFACGTAAVITPVGRVKTATDEWSQGTGEPGEVTLRLR
                     EALLALQTGRAEDRHGWMHPLG"
     aSDomain        complement(20187..20945)
                     /aSDomain="Aminotran_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS07080_Aminotran_4.1"
                     /evalue="4.30E-28"
                     /label="B591_RS07080_Aminotran_4.1"
                     /locus_tag="B591_RS07080"
                     /protein_end="343"
                     /protein_start="90"
                     /score="90.6"
                     /tool="antismash"
                     /translation="FRPDANARRFQASARRLAMPELPVETFIEACDLLVAQDKAWVPPH
                     GGEESLYLRPFMIATEVGLGVRPANEYLFVVIASPAGAYFPGGVKPVSIWLSENRVRAV
                     PGGVGDAKTGGNYAASLLAQAEAAAEGCDQVAYLDAVEHKWVEELGGMNLCFVYGDRLV
                     TPTLTGSLLAGVTRDTLLSLAADLGCRAEEGRVSIDQWREDSRSGALTEVFACGTAAVI
                     TPVGRVKTATDEWSQGTGEPGEVTLRLREAL"
     misc_feature    21765..21778
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
ORIGIN
        1 caacggcttc gacggacacc agccctacgc ccccgaagaa gtacgcgaag cactccagat
       61 cggccccgac gcccccatca tcacgaccga cgcacgccac cgcgccgacg ccaaaagcgc
      121 actcatcacc ctggtcgagc acgcactgat ggcccggctg cgctagcggt accgggcccc
      181 ggacacgccg acggcccccg cccttcccgg agttctccgg aggggacggg ggccgtcggg
      241 gtgttcgggg tgcgccgcgc ggggcggcgc ggggctcagc cctgccagct gtgcggggcg
      301 cggaagccgg gggtgcgctc caggcggcgc cagccggccc ggtcgcggcc gcgacgcgcg
      361 gccggggcgg gctgcgcggc ggcgcgggcc atcaggaggg cggtgatcgc cgccagttcc
      421 tcgggctcgg cgtggccctt ctcgacccgc aggaactgct cgggagtggc cggaacggtg
      481 ggtgtggcca tggggatgct tctccgtgtt ctggtgagtc cggtcgccgt cactggggcg
      541 ggttgccgtg cttgcgggag ggcaggtcgg cgtgtttggt gcggagcatg gccagggagt
      601 cgatgaggac ctggcgggtc tcggcggggt cgatgacgtc gtcgaccagg ccgcgttcgg
      661 cggcgtagta ggggtgcatg agctcggcct tgtactcctt gaccatgcgc gcgcgcatcg
      721 cctcggggtc gtcggcgccg gcgatctggc ggcggaagat gacgttggcc gcgccctcgg
      781 cgcccatcac ggcgatctcg ttggtgggcc aggcgtaggt gaggtcggcg ccgatggact
      841 gggagtccat gacgatgtag gcgccgccgt acgccttgcg caggatcagc gagatccggg
      901 gcacggtggc gttgcagtac gcgtagagga gtttggcgcc gtggcggatg atgccgccgt
      961 gctcctggtc gacgccgggc aggaagccgg ggacgtccag gagggtgacg atcgggatgt
     1021 tgaaggcgtc gcacatctgc acgaaccgcg cggccttctc ggaggcctcg atgtcgagga
     1081 ctccggcgag ggactggggc tggttggcga cgatgccgac gacctggccg tcgaggcggg
     1141 ccagggcgca gatgatgttg cgggcccagc gttcgtggac ctccaggcag tcgccgtcgt
     1201 cgaccagttc ctcgatgacc ttggccatgt cgtaggggcg gttgccgtcg gccgggacga
     1261 ggtccaggag ggcgtcgccg cgccggccgg ccgggtcggt ggcctcggcg gcgggcgggt
     1321 tctcccggtt gttctgcggg aggagggaga ggaggtagcg gacctcggcg aggcaggtct
     1381 cctcgtcgtc gtaggcgaag tggcagacgc cggaggtctc ggcgtgcacg tccgcgccgc
     1441 ccagaccgtt ctggctgatc tcctcaccgg tgacggcgcg cacgacgtcg ggtccggtga
     1501 tgaacatctg cgaggtctcg cggaccatga agacgaagtc ggtcagcgcc gggctgtagg
     1561 ccgcgccgcc cgcgcacggg ccgagcatca cgctgatctg cgggatgacc ccggacgcct
     1621 tcgtgttgcg ctggaagatc ccgccgtacc cggccagcgc cgagacgccc tcctggatac
     1681 gggcgccggc gccgtcgttg agggagacca gcggggcacc ggccgcaatc gccatgtcca
     1741 tgatcttgtg gatcttggtg gcgtgggcct cgcccagcgc gccgccgaag atccggaagt
     1801 cgtgcgcgta gacgaagacc gtccggccct cgaccgtgcc ccagccggtg atgacaccgt
     1861 cggtgtgggg cctcttctgc tccaggccga aaccggtcgc ccggtgccgg cgcaactgct
     1921 cgacctcccg gaacgaaccc tcgtccagca gcagggcgat ccgctcacga gcggtcagct
     1981 tccccttggc gtgctgcgcc gccgtggcct tctcacccgg accctgctcg gcccgctggc
     2041 gcagggcgtg gagttcggcc acgcggccac gggcgtcggc gggctcgctc ccggactcag
     2101 ctgtctcgtc caaaacggtc atgtagcgac tctacgaacc cgggccccga gaacctgccg
     2161 tcgactcctc acagtctccg ggccgttttc ctggagcggt ctcacaggcg gattggggta
     2221 cgcagcgcat tcgactgccg ggagggggtg cgcgttatgg ggttccgaca aaagccggtg
     2281 ggtcgcggtc ctctctccca cccgtaggga ccccacaagc ggctgcgccc ggacgagggg
     2341 cgccgcacgg cacgggtccg tccgccgagg gtagcggcgg acggacccgg gaggaaaacg
     2401 ggggcggcgg ggggcggtca gcagccgccg cagttgtagt aggtcacgtc ccagtggttg
     2461 ccctcgttgg cgtagacgtt gccggagccc gactggtact gggcggcacc gtcgccgcgc
     2521 tggccgatgt aggtgaaggt gccggtgacg tagttgttca ggcaggtgct cttggagaag
     2581 tcgagcttgt agccgttcca gtgcgagtag gtgccgccgg cgtggccggt ctcggtgccg
     2641 ccggtgatgt tgatggcgca gccgctcgcc gacttcaggg tctgggcgcc ctgggcggtg
     2701 gcgagattca gctggtcgaa ggaggtacag gtcgagacgt tgcggttgga gcaccccccg
     2761 gaggaggacc aggtgatgcc ggaggaggag aaccgcgagg tggcctgggc gtgggtgatc
     2821 ttggtggcgg ccgcgccggc ctcggcggtg gtggaggtgg gagccggtgc ggcggtggcg
     2881 gccgtggcgg tgccgatgac accgaacccg gctccggcga cgagggcgag ggcgctcagc
     2941 gccgagcgga tcttcatgga ggtcctcctt gcggggcgcg tgcggcgcac gcggcggtgg
     3001 gggtgcgtgg gggtggtgcg gaggccgtgc ggggcggggc agacgcatag tgcccgagtt
     3061 ctacgcgggt caccagaggg cctcaccgat cagttccggc caactagggg gcgcgttcgg
     3121 cgcgcgtgca tccgccggag ggccgccacc gaaggcgatc cgacggaaga tgttgaaagt
     3181 tgaaccgaaa cgcgttacct tcgaactcgt tgaaacttca acatctcctc cctgctccgg
     3241 agaccgtccg gagcacgtcc ccaaggagca cctcatgggc atcttcggcc gcaagaacga
     3301 gaccaccgac accaccgtca gccccgacct ggccgcgctg accggcacgt acacgctcga
     3361 cccgacgcac accacgatcg gcttcgtggc gcggcacgcc atggtcacca acgtcaaggg
     3421 cggcttcggc gacttcaccg gcacgctgac gctggacggc tccgacccgt cgaactccac
     3481 cgcggagatc gacgtggcca tggactccgt cgacaccggc aacgcggacc gcgacggtca
     3541 cctgaagaac gccgacttct tcaagaccga cgagttcccg aagatgacct tccgctcgac
     3601 cgaggcggag gcgctcggcg gcgacgacta ccggatcacc ggagacctga ccatcctcgg
     3661 caccacccgc ccgctctcca tcgacctgga gttcaacggc tccgccacgg acccgttcgg
     3721 caacgagcgc gtcggcttcg agggcaccgc ctcgatcctc cgctccgaat ggggcctgac
     3781 ctggaacgcg gcgctggaga ccggcggcgt cctcgtctcc gacaagatca agctggtctt
     3841 cgacatctcg gcgatcaaga acgcctgacg cggaccggcc cccaggggca ccggggcccg
     3901 agagccctgc cgagcgcgcc cgccctccct tccggagggc gggcgctcct gcgtgcgggc
     3961 ccgcctgccc caccgtgctg gtcggctccg acggctaccc ggtggcgctc tgcaccccgg
     4021 tcctcggcca ggtgccgacc gtgcgcctcc tgacgggcgg tgcaggaacg gccattcggt
     4081 ggccgccgtg aatgcgccgg tcactccccc cgcacgcccc gcacgttcgg gtgacgccga
     4141 gggtggcgcg ggcggggccg ggtagctgac ggtcggagcc gaagggtggg cgcgtaggtg
     4201 tgcgggcgga gcggatgccg ctcgcgcacc ccggccgacg cgccctctgc tgacccctcg
     4261 gcgccaccct ccgccctctc ctcaccgctc accgccgggg tcgtctcccc gctccggccg
     4321 ggggtggtcg gagggggcgg ttcaggggga gacgcggtag cccggcaccg agggccagcg
     4381 cacggtcatc acgacggacg gctcctcggc ctcccaggag tggtcgacgc ccttgcccca
     4441 gatcacgtac tgcccctgct cgctcaggac cacgtcccgc tcggggaact ccatccggaa
     4501 ccgtccgctg acgaggacca gcagcgcctg ccgctcctcc ccgcgcaccc aggcggcgcg
     4561 ccgctcgccc gcctcgtgga cgccccattt gatctccacg gcctcgttgt ggcgcgggtc
     4621 gtccggcgcc ttgaagtggc ccatgatcca gccggcgtcc agcgcggcct cctcgggggc
     4681 gttgcccacg tacacgttct cgctcatcct ccggacggta gtacacgtga gggtggtctc
     4741 cccggcggcc cgggggtggc cgggcggggg cagctttggt tgggtggggt ggtcctgctg
     4801 acacgttgtc gtacgacaga gggggttgag gtacgtgagg agcacagcgg aggtctccgt
     4861 ggcggccgtg atcgaggcgg agccgaaggc ggtctacgag cgggtcgccg acgtggcgtc
     4921 catggggcgg tggagtccgg agtgtgtgcg gacggcggcg ggcgtcgggc ccgcgccggt
     4981 gggcgccgag ttcaagggga ccaacaaggg gccgagcggc cggagctggt cgacgcggtg
     5041 ccgggtgatg gtggcccgct ccggtgagcg gttcactttc cgggtgcggt tctggggtat
     5101 gccggtggcc acctgggact accgcttccg cccggtcggg gacggcaccg cgaccgaggt
     5161 gaccgagacg gccgtggacc agcggaaccg gctcctgtgg ttcctcggtt cggcggtcag
     5221 cggcgtctgg gacaggagcg cgcacaacgc cgagaccatg cgggagaccc tggagcggct
     5281 gcgcgagacg ctggaggcgg agcggcgggc gggttaggac acgtccgggc ggcgttgtcg
     5341 gtgaggtgtg gtgggatcgg acacatgagc gatcaccaga cggcgggggc cgacggggaa
     5401 gaggcgcgcg cccgcgcggc ggtgcgggac gcctgggcgc gcatcgacgc gtggatgcgc
     5461 gcccacgccc cggactccta cgaggtactg gcaccgcctg ccgacccggc ggcggtggag
     5521 gcggcccagg ccgagctgga cgtgcggttc ccggcggacc tgctcgcctc cctcgcctgc
     5581 cacgacggcc tgcgccactg ggccaactgc ctgcccctgc gcccaccgct gcccgtcgcc
     5641 gacatcgtcg accactggca gatgtgcgtc gagatcgacg aggacaaccg cgccgacgag
     5701 gacgagccgg agcccgaggg cgaggagccc tggtggcacc cccagtggat cccgtgggcc
     5761 cagagcgacg gcgacgccca gatcatcgac atgcgcccgg gccccggcca gggccgcctc
     5821 ggcatggcct accacgacga ctgcggcgtc ttcggcgacg gctggccgtc cctggcgacg
     5881 tacctgaccg aggtcgccga cgtcctggag aagggcgggg cggtgggggg aacgtgggcc
     5941 ccctacctga cgaccgcggg cgagctgtgg tggtccctca agggcgagac ccagctcaac
     6001 ggcgagccgt tgacaccggc tccggcgccg tcggccggtt cctgacgccc tgccgggcgg
     6061 gggctgaccg caccggcccg atcaggtgac gcggcgcctc cgggtccggc cgcggttcga
     6121 cgggcggggc accgggcgtg gccggagtgt gcacgcggtg aagcggacac tcctgttcgc
     6181 gggcgcggtt cccgcggccc gcccgcccgg accaccgcag ggcgacgtgg tcccctctcg
     6241 acgacctcgc tcgggaggtc gaattgccgt ggtaggtcca ccgccacgtc ccggactcgg
     6301 tggccttcac ctgctctcac cggtcctcgt cccagatcgc ggtgtcgggg tcgatgccgt
     6361 gggcccgcgc ggcggcgtcg acgagttggc ggaaccaggt ggcgaggccg gggcggacgg
     6421 cgtcgtagtg ggcggcgaag cccggatcgc cctcatacat acggccgagg cagacctgca
     6481 tctgacggga gagggggaag taggacgcga agacctcgcg gtggcgttcg acgaggtggt
     6541 tcgcctccgg gctgccgggg gtgacgccgg agtccatcgc ctcgccgagg gcgcgttcga
     6601 gccgggcgac gtcgtcggcg acggcctgcc actcctccgg ggtgcgggag gccgagcgtt
     6661 cggcgtactg ccgccattgc gtcgtgtccc cgtagcgctg acgggcctgg accggaccgt
     6721 cggggctcca tccggggccg aagatcgcgg cctgttgctc ggcggtcagc agcaggccgt
     6781 gttcgtgggc gtcgatcatc cggtcgagtc cggcgccgag ttgctggagg cggtcgatgc
     6841 gggcggcgat ctgggcgcgt tgcgcgcgca gagcggccgg tacgtccgtg gccgcgtcgt
     6901 cgaggacggc gcggatcttg tccaggccga ggccgagttc gcggtagacg acgatgcggt
     6961 gcaggcgttc caggtcgggg gcggtgtaga gccggtatcc ggcgggcgtg cgcagggacg
     7021 gccgggccag gccgatctcg tcccagtggt ggagcgcccg gaccgtcacg tccaggcgcg
     7081 ccgaggcctg accgacggtc aggccctcgg cgtccggggt gtcaggcatg ccgctcattg
     7141 tcgcccgggg tctcgccggg cggggtgatg ccgatggctt cgaggttgcg tgcctcctgg
     7201 gtgtccgggt cgaagggctt cgcggcggtg aagacgatcc gcgcgttctc gggggtgatg
     7261 acttccacgt cacgggtgtt ccagggcgtg tcccgcggcc cctcgaccgc gtccgggcgc
     7321 agcgcacggc atgcctcgac gagggagtcg acctggctga gcacgccgga gaaactgaag
     7381 ctcatcgccg gcggctgttc cggaacgctc tccgcagcca cgaggagcac gtcctggaac
     7441 gcccatcgac gcagatgcac gagggtgccg gggatactga acagctcgaa gaagccgagc
     7501 ccccgcgtcc agaactccac cgacgccgcc agatcggtcg tcgggatgtt cacgaaggcg
     7561 ggcattccgt agatgccgcg gaacggctcc ggggggaccg cgtcgggccc gggagcgggc
     7621 acggggctga tctcgaacgc gttgtagtag gtgtcgtcgc tcatgtgccc cagcctcggg
     7681 cctcacgcaa cgtgagggtc aagccgggat cgtgcgttct gcgcgcccgg gagaaaagac
     7741 cgggcatccg gagcacgccc gtgccaggct ggccgcatga cgacctacca ccgaaaggcc
     7801 cgtgccgcgt aagccgccgg gacgggtgcg gaccggactc ccccgcccgc gcaggcccta
     7861 cgagaagtcg cccgtgatcg acgggttgtc gggcgggacg ctcgccgagc tggcccggct
     7921 ggagcgcacg cggaaccatc tgtggccggg agccgtgtcc gaggccgcac gcgcctgggc
     7981 cgggcacgtg cggctgccgc gcggccgcac ctggccccat ccgggacacg gcccctgcta
     8041 ctgctgcccc gacccgtggg agtcccggga actgctcgac caggtcgccc gcgccctgtc
     8101 ccggcgcggg gcgcgcgaac tgcggcgcgt actggcggcg cacgaccagc tctgggaccc
     8161 ggcgccccgg acgtaccggg gcgagggccc gtggtgaggc cggcgcgccc ccggcggacc
     8221 ctcgcggacc ctcgcggacc ctcgcggacc tcgccccggt tccggccgtc gcggctcagg
     8281 gcgacagcgg acggggctac ttccccgtgc aaccgacccc cacgggacgg aaggagcacc
     8341 agacgctctt gcccgggtcg cgctccccca ccccccagtc gtcggcgagg gcggagacca
     8401 ggagcaggcc ccggccggac tcggcctcgc cgccgggggc gcgggtcgcg gggcgcccgt
     8461 cgccactgtc gtggacctcg acgcgaacgc cgccgtcgtc ggcccggagc acgaagagcc
     8521 ggaagccccg gccgggcggg acgccgtgga gcagggcgtt ggtggccagt tcgctcacgc
     8581 agagcaagac gtcgtcgcgg cgcacgcggg cgtcccactc gtccagcacg gcggcggtga
     8641 agtccctggc tgcggggacg gatcggcgct cgcggcggta gaagcgctcg cagtgcgcgg
     8701 ggagtccggt ttcggtcttc accctcctac ggtcacccaa cgtcactagc cttgtgcagg
     8761 gcgtcggccc gtacaaatcc gttgtacggg ccgtgtcggg tgcgcgacgg ggcgcgtcgg
     8821 gagatggagt gcgtatgcag cagcggaaga agtccagcaa gaaggtcacg tcgtgggaag
     8881 tggtgggggc ccaactggcc gagtttcggc gctcggccgg actgacccag ccgcagttgg
     8941 ctggcacagc caaggtcggg gaagacacgc tcgcctcgat cgagcagggt cggcggcggc
     9001 tcaaggcgga cttggccgag ctgctggaca cgatcctcaa caccaagcgg gcgctggcaa
     9061 cggcggtgtc caagattccg gacagggagc gctacccggc tttcgcccaa gagttcgtgg
     9121 agcacgagca ggaggcgttg acgctgctct cgtatcagaa ccacgtcatt cccggccttc
     9181 ttcaaacgcc tgagtacgta gagcagatct acgccaacct ctttcctccg ctcagctctg
     9241 aagcaacgga ggtggccata cgagcacggt tggaccgcca gaacttgctg cacagggagc
     9301 cgccgcccgt gatgaacttc atcatcgaag agagcgtgtt ccagcggcac atgggaaatc
     9361 ctgatggcat gcgtcggcag atccgtcacc tacgcgaatg cgccgatctc ccgttcatcg
     9421 gcatccaggt gatgctgacc gcaacagacg cccacgcggg actggcggga cctctcgttc
     9481 ttctcgaaac gcctgaccac gaccacctcg cgtatgcgga agggcagcac aacggcttcc
     9541 tcatggatga cccggacgag gtcagtgcct atcagcagag gtatgggatg ctgcggtcgc
     9601 aggccctctc accgcagagg accaagagcc tgctgaacac actgttggag tgacatgacc
     9661 agcgaggccc cctccgtccg caacctgggc tggttcaagt ccagctacag cagcaacgca
     9721 ggcggcgact gcgtcgaggt cgcctacaac tggcgcaagt ccagctacag cggtgacttc
     9781 caggacgcct gcgtagaagt cgccgcccac cccaccgccg tccacgtccg cgactccaag
     9841 gtcccggcgg gacccaccct cgacgtgacc cccgccgcct gggcggcgtt cgtacacgcg
     9901 accgccggtc cactcgtatg acaacaccgc cgtccggctg acgggtcggg cgggcgggta
     9961 gtgatcgggc cgccggtatc accgtgtgga aggctcgacc gtgacacagc cctttgtcct
    10021 gcccgatttc tacgtgccgt acccggcgcg gctcaaccct catctggaag aggcgcgcgc
    10081 ccatgcccgg gtctgggcgg acgagatggg gatgctggag gggtcgggga tctgggacct
    10141 ggccgacctt gaggcccacg actacgcgtt gctctgcgcg tacacgcatc cggactgcga
    10201 cggtccggcg ctgtcgctgg tgaccgactg gtacgtgtgg gtcttcttct tcgacgacca
    10261 cttcctggag ctgttcaagc ggacgcagga ccgtgagggc gcgaaggcgt acctggagcg
    10321 gctgccggcg ttcatgccga tggatctggc cggcgggttc ccggagccgc agaatccggt
    10381 ggaggcgggg ctcgccgacc tgtgggcgcg gacggtcccg gccatgtccg aggactggcg
    10441 ccgccgcttc gccctctcca cggagaacct gctcaacgag tcgatgtggg agctctccaa
    10501 catcaacgcg ggccgcgtct ccaacccgct ggagtacatc gagatgcgcc gcaaggtcgg
    10561 cggcgcgccc tggtcggcgg ggctgatcga gtacgcggcg caggccgagg tgccggaggc
    10621 ggtggcgtac tcgcggccgc tgcgcgtgct caccgacgcc ttctcggacg gcgtccacct
    10681 gcgcaacgac ctcttctcct accagcggga ggtcgaggag gagggcgagc tgagcaacgg
    10741 cgtcctcgtg ctggagcggt tcctggagtg cacgacgcag gaggcggccg aggccgtcaa
    10801 cgacctgctg acctcgcgcc tccagcagtt cgagaacacc gcgctgaccg aactggggcc
    10861 gctcttcgcc gacaaggggc tgaatccggc cgagtccgcc tcggtgctgg cgtacgtgaa
    10921 ggggctccag gactggcagt cgggcggcca cgagtggcac atgcgctcca gccggtacat
    10981 gaacgagggc gcggtcgacg gggaggccgc gccgccgacg ccgggcgggt cgccgggggc
    11041 gctggcggcg gcgctgctgg gcggaacgct gggcacgtcg gcgctgaacg tgggggcgtt
    11101 cttcgggcgg ccggcgcggc agcgggcgcg cagcttctcg cacgtgccct accagaggac
    11161 gggggcctcg ctgctgccgg acttcaagct tccgttcccg acgcggctct ccccggcgct
    11221 ggagcagtcc cgggtggaca cggtcgagtg ggcgcaccgg atggggctgc tggtgccgca
    11281 gccgggggtg cccgggtcgg acgtgtggga cgaggaggcg ctggccggct acgacttccc
    11341 gctctgcgcg gccgggctcc acccggaggc ggacctggag gagctgaacc tcgcctcgga
    11401 gtggctgacc tggggcacgt acggcgacga ctactaccct gcggtcttcg gccgtacccg
    11461 gaacttcgcc ggggccaagc tctgcaccga ccggctgcgc gatttcatgc cggtcgagca
    11521 gccgtcggcg gggccggtgc cgaccagcgc gctggagcgc tcactcgccg acctgtgggt
    11581 gcggaccgcc tccgccatgc cggagaaggc gcgccgtgag ttccgtaaga ccatcgaggt
    11641 gatgctcgac agctgggtct gggagctgga caaccaggcc atcggccgca tccccgaccc
    11701 catcgactac atggagatgc gccgggccac cttcggctcc gacctgacga tgagcctgtg
    11761 ccgcctgcgc cacggcaaca tcgtccccga ggaggtgtat cgctcgggca ccatccaggc
    11821 gatggagaag gccgtctcgg actacggcgc gctcatcaac gacgtcttct cctaccagaa
    11881 ggaggtcgag ttcgagggcg agatccacaa cgccgtcctc gtcacgcaga acttcttcga
    11941 ctgcgactac ccgaccggcc tcgcgtacgt ggacgcgctg atgaacgcgc ggctggaaca
    12001 gttcgaacac atcgtggccc acgaactccc cgtgctgtac gaggatttcc agctggacgg
    12061 ggcggcccgg aaggtgctcg acggatacgt gcggcagctg gagaactggc tgtcggccat
    12121 cctgacctgg caccggggct gcaagcggta caaggaggag gacctgagcc accactcccc
    12181 cggcgtgcgg cgggtgatcg aggccgcgcc gcgcgggatc gggccgaacg ggctcggcgc
    12241 ctcgacgctg ggcacggccg ccgcccgggt gttcgccgcg gggtgacggg agcgggccgg
    12301 gggtgagtgg ctccggcggg gtcagaagcc tccgccgaag tcaccgcctc cgcccccgaa
    12361 cccgccgccg tccccgaagc cgcctccgcc gccgaagtca ccggggtcga agtcggagcc
    12421 ggaggcgtcg ccaccctcgt agccgccgcc cgcgccaccg tcgccgaacc cttcggccga
    12481 gccgtagtcg gcggcgtagg cggggctcat catcatgtgg ccgagcatgg tgccgacgag
    12541 gatgccgggg aggatgccgc cgccgaagta gccgccggcc caggggccgt acgccgggcc
    12601 ggcctcccag tacgggcgcc ggccgcccgc gtcggactcg acggtgcgga tgtcggggtc
    12661 ctcgccgcgc tccagccgtg cctggtcggc ggcgcagacg ggcacctcgc ggggcgcgcc
    12721 gccgggcggg gcccaggtga cgtcggcgac cgagaggccg tggcgcgggt cgaagaagca
    12781 cggcgggcgg cgcacgggca gctcacggcc gctgcgccgg gcgtcgagca cggcgagagc
    12841 gaaccggccg tcctccagcg ccttggtcac ctcgcgcacg tcctcgggct tctgcgcgtg
    12901 gtccatgagg gacttggcgt tctcgtaggc gtcgagaccg cgctcgtagt cgccgcgcat
    12961 ctcgtcggtg gcgcccggtt ccaggggccg gaagtcgagc cgctccagtt cctcgccgaa
    13021 cgcggtgatg tcctcgtcca ccacgacccg cagcttggcc agcgcctcct gctgggcctg
    13081 ctcgcgccgg atcttgcgcc gccgggtcag cgtgtacgcg gcgccgccca ccaccacgac
    13141 ggcgatgccg aggccgagcc aggtcgcccc ggagacgctg tcctgggagg accaggaggt
    13201 gggggcgcgg ccgcccatgt tctgggtggc gttgcccacc aggccggtga gctgttcgcc
    13261 ggccggggtg gtgtcctgga agcgggattc gaggttctgc acggcctgcc gggagaggac
    13321 cgattcgtcg gcgcggacgt gcaggtcgtc accgatgcgc aggacgtaca ggccggtgat
    13381 gccggtgtcg ccgcgcaggt cgttcatggt ctggtcgacg tcgtccgtga aggtcgccgg
    13441 gaggaccgcg acgaagatcg ccttgtcgct gtcctggatc tcctgcgaga ggtcacgcgc
    13501 gtcggcgtcg gagagctggt cggagacgtc cggatccacg aagacggggc cgtcgcgcca
    13561 tgccttggcg acctcggaga cggtcgcggc ggcgggggcc tgcggcgccg cccgcacggg
    13621 tgccacggcg gcgggccggc cctggtcggg ggcggcgacg gccggcgcgg ccgtcgctcc
    13681 ggcggcgccc agcacgagaa ggggcccgga cgcgatgaga gcgccccggc gtatggactg
    13741 gcggactacg gctcgcctca tacctccacg ctaacccggg tcgcggcgat gcgccccgaa
    13801 cgggcggcgg gacaggtgcg ggccccgccg ccccgggcgt gcgcgcgtcg ggcctactcg
    13861 gcgggctcga ccccggcgcg gagcaggccg taggtgtagg cgtccgccag ggcgtgccag
    13921 gaggcggcga tgacgttctc ggcgacgccg accgtcgacc actccgcgtc gccgtcaccg
    13981 gtggagatca ggacgcgggt ggtggagtcg gtgccggagc ggccttccag gatgcggacc
    14041 ttgtagtccc gcagggcgaa cttggccagc tccgggtaga tccgctccag ggcgacgcgc
    14101 agggcgcggt ccagggcgtt gacggggccg ttgccctcgg cggtggcgag gaggcgttcg
    14161 cccttggccc agagcttcac ggtggcctcg ttggcgtgga tgccgtcggg gcggttctcg
    14221 gtgatcgccc gccacgactc gacgcggaag aagcgggagg gggccgcgtc gcccgcaccg
    14281 tcggtgccgc gccgcagctc gtcacggagc agcagctcga aggaggcgtc ggcggcctcg
    14341 taggagtacc cggccagctc gcgttccttg acgcgctcca cgacgcggcc gaccagggcg
    14401 cggtcgtcgc cgaggtcgat gcccagctcc ttgcccttca gctcgacgga ggcgcggccg
    14461 gccatgtcgg agacgagcat ccggatgcgg ttgccgacca gctccgggtc gatgtgctgg
    14521 tacaggtcgg ggtcgacctt gatcgcggag gcgtggagtc cggccttgtg ggcgaaggcg
    14581 gagacgccga cgtagggctg gtgggtggag ggggtgaggt tgacgacctc ggcgatggcg
    14641 tgcgagatgc gggtcatctc ggcgagcgcg ccttcgggca gcacggtgcg gccgtacttc
    14701 agctccaggg cggcgacgac ggggaagagg ttggcgttgc cgacgcgctc gccgtagccg
    14761 ttggcggtgc actggacgtg ggtggcgccg gcgtcgacgg cggcgagggt gttggcgacg
    14821 gcgcagccgg tgtcgtcctg ggcgtggatg ccgaggcggg cgccggtgtc ggcgaggacg
    14881 gtggcggtga cggcctggat ctgcgcgggc agcatgccgc cgttggtgtc gcagaggacg
    14941 acgacgtcgg caccggcctc gctcgccgcg cggacgacgg ccttggcgta ggccgggttg
    15001 gcggcgtacc cgtcgaagaa gtgctcgcag tcgacgaaga cccggcggcc ctgggcgcgc
    15061 aggtgggaga cggtgtcgcg gaccatctcc aggttctcgt ccagggtggt gcgcagggcc
    15121 agctcgacgt ggcggtcgtg ggccttggcg accagcgtga cgaccggggc gccggagtcg
    15181 aggagcgcct tgacctggag gtcgtcggcg gcgctgccgc cggcccggcg ggtggcgccg
    15241 aaggcgacga gctgcgcgtg gcggaaggtg atctcctcgc gggcgcgggc gaagaactcg
    15301 gtgtcccgcg ggttggcgcc gggccagccg ccctcgatga agcccacccc gaagtcgtcc
    15361 aggtgccggg cgatggtcag cttgtcggcg acgctgaggt tgatgccctc acgctgcgcg
    15421 ccgtcgcgga gcgtggtgtc gaagatgtgc agggggcgct cgacggcggc gtccacggcg
    15481 gcggaggacg tcgcggaggc gggggttccg gcggttgcgg ggcgcgcccc gtcgccgccc
    15541 cgtacgtcgc gtgcgacctg cggtttcgtc gcggccgacg gggcgcgctc agcgggttcc
    15601 tcgggggtgg cctggctggt catgcggtgg tgactcctgt cgggtgagtg gctccggaat
    15661 gcttggctcc acttgccccc atcctctcgt gcgcctcgcc gcggcccggt cggggccgac
    15721 aaacgaaaag acccctcgcg ggtgcgagag gtctgcgcgc gggtctgggg cacggtggcc
    15781 gcgtcgcacg tggtggtgcg gggcggtcac tgcggaccgg cgcgcctgct gccgataatc
    15841 atggcgaacg tgggcacggg ggcagtcttc cacagagacg cctccgtgcc accgggtgtc
    15901 tcaggatgcg agcggggcgt ccgttctcgc gggcggggag gccggggagg cggggccggc
    15961 ctgggcgggg gaagggttcg gccatcagcc gacggcgaag atgcccaagg tgttcatgag
    16021 ctgggcggtc gggttgccgc caaggaaccc gcgtagtacg tggcgaagct cgcgtacacg
    16081 gaccagtcga accactcggc catgttgccg gccgagccgg cccaggtgct ttgcggtcgt
    16141 ggggcgggga cgccgggcgg ctcagccccg tgcgccccgg gccggcgccg gttcctgctg
    16201 ggtgatgcag tggatgccgc cgccggcggc gaagaccggg cgggcgtcga cggggacgac
    16261 ggtgcggtcc gggaagaggc ggcggaagag cgcggcggcc tcggcgtcgc gcgggtcgtc
    16321 gaaggcgcag aggacgaccc cgccgttgca gaggtagtga ttgatgtacg agtagtcggc
    16381 ccactccccg tccacctcca gcacggtggg cgcgggcacc tcgaccacct ccagcggccg
    16441 gcccgccgcg tcccgggcgg cgcgcagcac accggtgatc tccttgcaga cctcgtggtc
    16501 ggggtgggcc gggtcgggct gggtgtgcgc cacgaccacg ccgggccgcg cgaacgccgc
    16561 gacgatgtcg acgtggccgc gcgtcccgaa ccgcccgtag tcaccggtca gcccgcgcgg
    16621 cagccacacc gccttgctgg ttccgagccc ggcgtggatc tcggcctcgg cctcggcacg
    16681 gctcaggccg gggttgcggt ccgggtcgag ctggacggtc tcggtgagca gcacggtccc
    16741 ctccccgtcg acgtgcagcc cgccgccttc gttgaccagc cccgtccggt acgccgtgac
    16801 cccggccagc gcggccacct cgccgccgat cttcgcgtcg tgctcccagc gggcccactc
    16861 ctgcgcgccc cagccgttga acgtccagtc gagcgcggcc cgggtgccgt cgtccgcacg
    16921 ggtgacgaag gtggggccga tgtccctcat ccaggcgtcg tccagcgggc gttcgagcac
    16981 gtcgacgccg ggcccgagga gcgcgcgggc gccttcggcc cggccgggtc cggcgaggac
    17041 ggtgaccggt tcgaagcggc gtacggtgcg ggccacctcg gcccaggcgc gttcggccga
    17101 ggccagtgcg gtctcggtgg cgaaggtggg gttggggccg ggccaggcca tccaggtgcg
    17161 caggtgcggg gcccactcgg gcggcatgcg gaagcccggc gggacggtgc cgcgcaggga
    17221 cggggcgggg gcgtcgggca tggcggtcct cagaggaagt agaggcggtt gaggctgacg
    17281 gagtcggcgg ggccggagcg gaccgggtga ccgtcgaggg tgacgaggcc ggtgcgggcg
    17341 tccacgtcga cctggccggt gcgggagttg aggaggagat cggcggggcc gatgttccgg
    17401 gtgccgcgca cggggacgcg gcgcctgcgg gtgggcaggg cgtcggcgcc gaggcccacg
    17461 gcggcgcccg cgacgaaggc gacggacagc tcggcggcgg ccgccccgtg cgcgccgaac
    17521 tggggtccga ggacgagtgg ttcgctggtg tcggtggcgg cgttggggtc gccggtgacg
    17581 ccgtaggcgg ggaagccgga cttcaggacc agttggggct tggcgccgaa gtactcgggg
    17641 cgccacagca cgatgtccgc cagcttgccg ggctccagcg agccgacctc gtgggagaga
    17701 ccgtgcgcgc gggccgggtt gacggtcagc ttggcgaggt agcgcaggac gcgggcgttg
    17761 tcgtcgccct cgccgtcgcc gtccagcggg ccgcgttcgc gcttcatctt ggcggcgagc
    17821 tggagggtgc ggcggatcgt ctcgccggcc cgccccatcc cctgggcgtc ggaggaggtg
    17881 atgccgatgg cgcccaggtc gtgcaggacg tcctcggcgc ccatcgtcga ctcgcggatg
    17941 cggtcgcggg ccatcgcggc gtcgccgggc agctcgggct tgaggtcgtg gaccgagacg
    18001 atcatgccgt ggtgctcggc gacggcgtcc cggccgaagg gcagcgtggg gttggtggag
    18061 gagccgatga cgtggggcac gcccgccatg cgcagcacgt tcgggacgtg gccgccgccg
    18121 cacccctcga tgtggaaggc gtggatggtg cggccgtcga gcacctggag ggtgtcctcg
    18181 acggagaggc attcgttgag gccgtcgctg tgcagggcca cctgcacgtc gtactcctcg
    18241 gcgacgcgca gcgcggtgtc cagcgcccgg ctgtgcgccc ccatgtcctc gtgcaccttg
    18301 aacccgcacg ccccgccctc cgccagcgcc tcgaccagcg gcgcggcgtg cgaggaggaa
    18361 ccccgggcga ggaaaccgat gttgaccggc caggcgtcga aggcggcgaa ggcgtgccgc
    18421 agggcccacg gcgagttgac gccgacgccc cagacggggc cgaactcctg gccgatgatc
    18481 gtggtcacgc cggaggcgag ggaggcttcc atgacgcggg gcgagagcag gtgcacgtga
    18541 gtgtcgatcg ccccggcggt cgcgatcagc ccctcccccg acacgatcgt ggtgccggtg
    18601 ccgaccacca cgtcgacccc gtcgagcgtg tccgggttcc ccgcgcgtcc gacggcgtgg
    18661 atacggccct cgcggacacc gatcgagact ttgcggatgc cgagcaccgc gtcgatcacc
    18721 agcacgttgc tgatcaccag gtcgcaggtg tcgcgcacgg cggcggcccg caggtgcagc
    18781 ccgtcgcgcg cggtcttccc gaacccggcc aggaactcgt cccccggccg ctgcgcgtcg
    18841 gcctcgaccc gcaccgtcag ccccgtgtca ccgagccgca ccctgtcccc ggtgcggggc
    18901 ccgtggacgg cggcgtaggc gtagggatcg gagcccctgg ccgcctcgtc gggcgcggta
    18961 cggcggccgt gcggggtacg ggccgggtgc gggaaggcgc gggggcgcgg ggtcagcccc
    19021 tcgggaaggg cccggccggt ggggtcgctc atgcgtcggt ctccggggcg ggggtgccgg
    19081 gcaggacggg ggtggcgccg ggcggggcgg gctccgcccc gggcgccccg gctccgaggt
    19141 agccgcaggc ggcggcgcgg cgcagggcct cggcgcgggc gccgggggcg tccagcgggc
    19201 cgtcgaccag cccggcgaag ccggtcacga cgcgcgcccc gccgatcggc accagccccg
    19261 cctcgcgggt ctcgccgggg ctgaagcgga gcgaggagcc tgccgggacg gcgagccgca
    19321 tgccgtaggc ggcggcccgg tcgaagctca ggcgcgggtt ggcctcgaag aagtggaagt
    19381 gcgaggtgac gctgaccggg accgtggcgg tgttggtgac ccgcagggcc agtacggggc
    19441 ccggcccggc gtggggcgtg cccgggagca gggcgcctgg cgcctggtcg ccggtgtggc
    19501 cgccgccgat gggatcggcc agcacggcga gccgggtccc gtcctcgaaa accgcctcga
    19561 cctggatctc ggtcagcacg tcggcgacgc ccggcagcac gtcgtccggt ccgagcacgg
    19621 cccgccccac cgccaccgcc tccgccagcc gcgccccgtc ccgcgccgcc tcgcagaccg
    19681 tgtccgagat gagcgcggtc gcctccggaa cgttcagccg gagcccccgc gcctgccggg
    19741 cccgggcgag ctgggcggcg ttgaagatca ggaggcggtc gcgttcggtg ggggtcaggc
    19801 gcatggaggt cctggagggg cgggggtggg cgggcgatgg agcgtcaccc tatctaaagc
    19861 atttaggttt tccaatggat ggcggatcgc gaagcaggcg cttgggcccg ggggcggcca
    19921 ggaggccccc aggggccggt ccggtaaggg gcggccccgt cacccccgta cctgcgagac
    19981 ccccgcgagg ctgccacgcc ggtgccgcct ctgacccgaa acggcccgcc gcccccgcat
    20041 ccgctgcgga gacggcgggc cgtcccggtc gtccgatccg cccggcccca ggcgatctca
    20101 cgccccgggc accgggcccc cgaccctcag cccagcgggt gcatccaccc gtgccggtcc
    20161 tccgcgcgtc ccgtctggag ggcgaggagg gcctcgcgga ggcggagggt gacctcgccg
    20221 ggttcgccgg tgccctggct ccactcgtcg gtggcggtct tgacccggcc gacgggggtg
    20281 atgacggcgg ccgtgccgca ggcgaagacc tcggtcaggg cgccgctgcg gctgtcctcg
    20341 cgccactggt cgatggagac gcgcccctcc tcggcccggc agccgaggtc ggcggcgagg
    20401 gagaggaggg tgtcgcgggt gaccccggcg aggagggagc cggtgagggt gggggtgacc
    20461 aggcggtcgc cgtagacgaa gcagaggttc atgccgccca gttcctcgac ccacttgtgc
    20521 tcgaccgcgt cgaggtaggc gacctggtcg cagccctcgg cggcggcctc ggcctgggcg
    20581 aggagggagg cggcgtagtt gccgccggtc ttggcgtcgc ccacgccgcc ggggacggcg
    20641 cggacgcggt tctcggagag ccagatcgag acgggcttga cgccgccggg gaagtacgcg
    20701 ccggccgggg aggcgatgac cacgaaaagg tactcgttgg ccggcctgac gccgagcccg
    20761 acctccgtgg cgatcatgaa gggccgcagg tagagcgatt cctcgccgcc gtgcggcggg
    20821 acccacgcct tgtcctgcgc caccagcagg tcgcacgcct cgatgaaggt ctccacgggc
    20881 agctcgggca tggcgaggcg gcgcgcggat gcctggaagc ggcgggcgtt ggcgtcgggg
    20941 cggaagctcg ccacggagcc gtcggggcgg cggtaagcct tgagtccctc gaagatctcc
    21001 tgggcgtagt ggaggacgtt ggtggcgggg tcgagggaga gcggcccgta ggggacgagc
    21061 tggccgtcgt gccagccgcg gccctcggtc cacttcacgg tgaccatgtg gtcggtgaag
    21121 tgccggccga agccggggcg ggcgaggatc gcctcgcgct cggcctccgg gagcgggtgc
    21181 gcggagggct tcagttcgat cgtcggcgtc gtcatgagtg gtgtccttca cgtgtggtgg
    21241 tgacagaccg cgctcacgcc cgtacccctg agcggtgcgt ggccggggtg ctgtctcgca
    21301 ctccggtcag ctgtgcacca cacggacgtc cgggtatcgc ctcattttcc gcggccccac
    21361 gtccgattat cgcgccggag ggggctgtga gggaacgccg aggagtccac cgccccgccg
    21421 aacgtgtcac gcggcggagc ggcagagggg tgcggggtga gcacgggccc tgggttgtcg
    21481 cacccggggc cgcccatgag gaagccgccg ggttgtcccg tgggggaccc ggcggcttcg
    21541 ggtgtcgcgc gccgggtcag ccggctactc gtccggcgag cgcgtcgccg atggcgtcgg
    21601 tggaccgcgc ggtggagtca cgctccgcca ggtcggcgga gacggcctcc tcgatgcggg
    21661 cggcctcggt ctcgtagccg aggtgccgca gcaggagggc gacggagagg atggcggcgg
    21721 tcgggtcggc cttgccctgc ccggcgatgt cgggggcgga gccgtggacc ggctcgaaca
    21781 tcgacgggaa ggcgcccgtc gggttgacgt tgccggaggc ggccaggccg atgccgccgg
    21841 tgacggccgc ggcgaggtcg gtgatgatgt cgccgaagag gttgtcggtg acgatgacgt
    21901 cgaaccgctc gggctgggtg acgaagaaga tcgtcgcggc gtcgacgtgc aggtagtcgg
    21961 tggtgacgtc cgggtactcg gcggcgacct tgtcgaaggt gttcttccac aggtggccgg
    22021 cgaagacgag cacgttgttc ttgtggacca gcgtgagctt cttgcggggc cgcgcctggg
    22081 cgcgggcgaa ggcgtcacgg accacgcgct ccacgccgta cgccgtgttg acgctgacct
    22141 cggtggcgac ctcggcgggg gtgccggtgc gcagcgagcc gccgttgccc gtgtaggggc
    22201 cctcggtgcc ctcgcggacc accacgaagt cgatctccgg acggccggcc agcggggtgg
    22261 cggtgttcgg gaagagcttc gagggg
//
