LOCUS       NZ_CP106650            22583 bp    DNA     linear   CON 16-MAY-2024
DEFINITION  Streptomyces sp. GBA 94-10 4N24 strain GBA 94-10 chromosome,
            complete genome.
ACCESSION   NZ_CP106650
VERSION     NZ_CP106650.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. GBA 94-10 4N24
  ORGANISM  Streptomyces sp. GBA 94-10 4N24
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7025021)
  AUTHORS   Ian,E., Malko,D.B., Sekurova,O.N., Bredholt,H., Ruckert,C.,
            Borisova,M.E., Albersmeier,A., Kalinowski,J., Gelfand,M.S. and
            Zotchev,S.B.
  TITLE     Genomics of sponge-associated Streptomyces spp. closely related to
            Streptomyces albus J1074: insights into marine adaptation and
            secondary metabolite biosynthesis potential
  JOURNAL   PLoS One 9 (5), e96719 (2014)
   PUBMED   24819608
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7025021)
  AUTHORS   Ruckert,C., Busche,T. and Kalinowski,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-SEP-2022) CeBiTec, Uni Bielefeld, Sequenz 1, Bielefeld
            33615, Germany
REFERENCE   3  (bases 1 to 7025021)
  AUTHORS   Ian,E., Sekurova,O.N., Malko,D.B., Ruckert,C., Borisova,M.E.,
            Albersmeier,A., Kalinowski,J., Gelfand,M.S. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-MAY-2013) CeBiTec, Bielefeld University,
            Universitaetsstr. 27, Bielefeld, NRW 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-NOV-2021
            Assembly Method                   :: flye v. 2.9-b1768
            Assembly Name                     :: GB94_v2
            Genome Coverage                   :: 229.4x
            Sequencing Technology :: Illumina MiSeq;Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000495635.2-RS_2024_05_16
            Annotation Date                   :: 05/16/2024 06:31:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,298
            CDSs (total)                      :: 6,204
            Genes (coding)                    :: 5,988
            CDSs (with protein)               :: 5,988
            Genes (RNA)                       :: 94
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 216
            CDSs (without protein)            :: 216
            Pseudo Genes (ambiguous residues) :: 0 of 216
            Pseudo Genes (frameshifted)       :: 100 of 216
            Pseudo Genes (incomplete)         :: 164 of 216
            Pseudo Genes (internal stop)      :: 24 of 216
            Pseudo Genes (multiple problems)  :: 67 of 216
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:13:11
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 284147
            Orig. end                         :: 306730
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP106650.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Wittmann Lab, Saarland
            University, Germany.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22583
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22583
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22583
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12583](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12583)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    1399..1410
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.75"
                     /tool="antismash"
     gene            1552..2757
                     /locus_tag="B591_RS01160"
                     /old_locus_tag="B591_01174"
     CDS             1552..2757
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640245.1"
                     /locus_tag="B591_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01174"
                     /product="sensor histidine kinase"
                     /protein_id="WP_023421121.1"
                     /transl_table=11
                     /translation="MHARTAWQALAHHPLAFLATLWPWRALAYLLSGVGVGALTLVVLV
                     AGLLTGLVLLPVGVGAAVLLAVVLGGGVVARVERWRLRLVDLDPAATDHRAPDAPGARA
                     WLRTRLRDRLTWRELGFTAVSMTALWWMDLLVLAFALALPVLCVTAPLDDPDAWPWVVI
                     GLALLPAAPYTVTGWAGARAALTRLVLAPRDAELTEVRASRARLVGAFDAERRRIERDL
                     HDGAQQRLVSVNVMLGLARLDAGPDSALGRRLDAVQGELRTAVGELRDLSRGVHPRALT
                     DQGLAAALTNLTARSPLPVTVDVALPGPLPASVASTAYFVVAEALANATKHSGAGCAEV
                     RARLRTDTLVLTVRDDGSGGADPAGRGLTGLADRVAAADGILRLSSPSGGPTLLHVEMP
                     CH"
     gene            2748..3395
                     /locus_tag="B591_RS01165"
                     /old_locus_tag="B591_01179"
     CDS             2748..3395
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468722.1"
                     /locus_tag="B591_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01179"
                     /product="response regulator transcription factor"
                     /protein_id="WP_023421122.1"
                     /transl_table=11
                     /translation="MSLKVVVAEDSALMREGLVGVLTRFGHQVCAAVGDADALLAAAGE
                     HRPDLVLTDIRMPPGQGDDGLRAAVALRRDHPDLPVLVLSQYLEQSYAAHLLDLGDQRG
                     VGYLLKDRVAAVTDFADTVVRVAGGGTVLDPEVVRQLLRRREDPLSRLTPREREVLALM
                     AEGRSNAAIARALHVSVAAVNKHIGSILQRLGLPLDGDAHRRVLAVLAYLRS"
     gene            complement(3408..4244)
                     /locus_tag="B591_RS01170"
                     /old_locus_tag="B591_01184"
     CDS             complement(3408..4244)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894526.1"
                     /locus_tag="B591_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01184"
                     /product="aldo/keto reductase"
                     /protein_id="WP_037786872.1"
                     /transl_table=11
                     /translation="MTTDVWRIGGELEVGRLGFGAMHLPTEPGPERKNALAVARRAVEL
                     GVTLIDTAHMYGGGANEELLAEALHPYPDDLLITTKVGMARSAAGEWDHDARPEALRDQ
                     VEQALRRLRRDHIGFLQLHRIDPSVPLADQLGALRELREEGKIGHIGLSEVTVGELDEA
                     RRTTEIAGVQNRYNLLDREHEPVLAACASAGIAFLPWRPAAWGDSGAHAEVASVAAELG
                     ATATQVSLAWLLGHSPVILPIPGTADPAHLEENTAAARLRLPAAHRARLDRLAAPA"
     gene            complement(4308..5240)
                     /locus_tag="B591_RS01175"
                     /old_locus_tag="B591_01189"
     CDS             complement(4308..5240)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (17-307). E-value: 2.3e-55.
                     Score: 179.8. Matches aSDomain:
                     nrpspksdomains_B591_RS01175_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468724.1"
                     /locus_tag="B591_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01189"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_023415724.1"
                     /sec_met_domain="ADH_N (E-value: 1.5e-08, bitscore: 33.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.3e-19, bitscore:
                     69.0, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAIIQESHGGPEVLHETRVPRPEPGPGEILVAVRAAGVNPTDWK
                     HRAQAGFVDRLPLILGWDVSGVVEAVGYGVTLFAPGEEVFGMLPYPHGSGSHAEYVVGP
                     ARAFTRKPTVIDHVQAGALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIA
                     KAHGAYVIGTASAPKHDLLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVG
                     LLRPGGTLVSLLSGGSAEEAARAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVE
                     ATFPLAEAAAAHRLGETGRTTGKIVLEVD"
     aSDomain        complement(4320..5189)
                     /ASF="ER configuration inconclusive"
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS01175_PKS_ER.1"
                     /evalue="2.30E-55"
                     /label="B591_RS01175_PKS_ER.1"
                     /locus_tag="B591_RS01175"
                     /protein_end="307"
                     /protein_start="17"
                     /score="179.8"
                     /tool="antismash"
                     /translation="TRVPRPEPGPGEILVAVRAAGVNPTDWKHRAQAGFVDRLPLILGW
                     DVSGVVEAVGYGVTLFAPGEEVFGMLPYPHGSGSHAEYVVGPARAFTRKPTVIDHVQAG
                     ALPLVSLTAYQALIDTAGIGPGQRVLIHAAAGGVGHVAVQIAKAHGAYVIGTASAPKHD
                     LLRELGADEVVDYRTTDVAEAVDGVDMVLDPLGGETRARSVGLLRPGGTLVSLLSGGSA
                     EEAARAAERGVRTATMLVEADHAGMNAVADLVAAGALRPRVEATFPLAEAAAAHRLGET
                     GRTTGKIVL"
     CDS_motif       complement(4752..4814)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B591_RS01175_0001"
                     /evalue="1.70E-08"
                     /label="PKSI-ER_m5"
                     /locus_tag="B591_RS01175"
                     /protein_end="163"
                     /protein_start="142"
                     /score="26.8"
                     /tool="antismash"
                     /translation="GQRVLIHAAAGGVGHVAVQIA"
     gene            complement(5324..6394)
                     /locus_tag="B591_RS01180"
                     /old_locus_tag="B591_01194"
     CDS             complement(5324..6394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409380.1"
                     /locus_tag="B591_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01194"
                     /product="MGDG synthase family glycosyltransferase"
                     /protein_id="WP_023415725.1"
                     /transl_table=11
                     /translation="MGSLRVLLLGASMGAGHDAVSGELARRLRAGGATTELCDVLTLLP
                     PGTGTVLRACYRATVRHAPALYAAVYALFLSPGDGHRPGSAPLAATARARLLRRVHAFR
                     PDLLVPTFHLAAQITGRLRAEGVLPVPASVFVTDFAVHRGWLHPGNDLYVCLTAQGAEA
                     ARAATGRPAAVSGPVVAPEFHRAAGPHPHGPVPGPPPVLLSTGAWGVGTRTVRTARLLA
                     AHGCRPVLLCGRDERLRRRAARVPGAVALGWTDDMTGLMGAARLLVDNAAGQTAAQALA
                     AGVPVLAWRPLPGHGRDGARSMAAAGLSTYAHDPDELLAGVRRLLCPGPVRTGQVERGR
                     AAFVADAAELLTRPTG"
     gene            6591..7382
                     /locus_tag="B591_RS01185"
                     /old_locus_tag="B591_01199"
     CDS             6591..7382
                     /EC_number="1.-.-.-"
                     /NRPS_PKS="Domain: PKS_KR (13-177). E-value: 1.2e-16.
                     Score: 53.1. Matches aSDomain:
                     nrpspksdomains_B591_RS01185_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409381.1"
                     /locus_tag="B591_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01199"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_023415726.1"
                     /sec_met_domain="adh_short (E-value: 2.7e-30, bitscore:
                     104.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRPEPGGVPRRTVLVTGASSGIGAAVAQSLHADGRWRLLLSGR
                     DGQRLAAVAERTGGEAIRADLAAEGGCEHLAAEAVARAGRVDALVAGAGIGWAGPFVTM
                     PPEEIDRVLTVNLTSTLRLVRLLLPSMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGA
                     LLTFADSLRRELAGTRVRVSVVSPGAVDTPFFARRGTPYHRRRPRPVSADRVARGVREA
                     LVRGRENVLVPGWLALPARLHGAAPGLFGAVADRADPHRGD"
     CDS_motif       6630..6725
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B591_RS01185_0001"
                     /evalue="7.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="B591_RS01185"
                     /protein_end="45"
                     /protein_start="13"
                     /score="15.4"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAQSLHADGRWRLLLSGR"
     aSDomain        6630..7121
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS01185_PKS_KR.1"
                     /evalue="1.20E-16"
                     /label="B591_RS01185_PKS_KR.1"
                     /locus_tag="B591_RS01185"
                     /protein_end="177"
                     /protein_start="13"
                     /score="53.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGASSGIGAAVAQSLHADGRWRLLLSGRDGQRLAAVAERTG
                     GEAIRADLAAEGGCEHLAAEAVARAGRVDALVAGAGIGWAGPFVTMPPEEIDRVLTVNL
                     TSTLRLVRLLLPSMVARGTGRLVLIGSMAGWVGVGDEAVYSASKGALLTFADSLRRELA
                     G"
     CDS_motif       7008..7040
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B591_RS01185_0002"
                     /evalue="2.40E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="B591_RS01185"
                     /protein_end="150"
                     /protein_start="139"
                     /score="1.3"
                     /tool="antismash"
                     /translation="VLIGSMAGWVG"
     gene            7398..8279
                     /locus_tag="B591_RS01190"
                     /old_locus_tag="B591_01204"
     CDS             7398..8279
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018468727.1"
                     /locus_tag="B591_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01204"
                     /product="DMT family transporter"
                     /protein_id="WP_023415727.1"
                     /transl_table=11
                     /translation="MTVLTVVLALLAALGNAAASVLQRRGTTQVDGVGAAVARWWSWAT
                     RLLRRRVWLWGAALLAVSGLCQAAALAAGPLAVVQPVMTTELLFTMVIGSAVFRRRPDV
                     RTWWAFVAMAAGLGAFMALLSPTGGGSTVPGSRWLWSGVLLAVLMLVLTVVAWRLPPAP
                     AAAVLGTATAIGFAGTAALVKDALGRVPDGGLGALATTWQAYAAVVVGLGSFLLLQLTL
                     RAGPLVASQPAMTLGDAFLSMLLGRVLFGEELTLGVRLVPELLALALLIAGTVQLARSP
                     LLTSTDGMERPW"
     gene            8273..9043
                     /locus_tag="B591_RS01195"
                     /old_locus_tag="B591_01209"
     CDS             8273..9043
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008409383.1"
                     /locus_tag="B591_RS01195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01209"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_037786873.1"
                     /transl_table=11
                     /translation="MVSAPGTAAGALAGGALAVAAWHIGPAATWLPGLRTAYFPGLDGR
                     GSPGQVALTFDDGPDPLSTPHFLRALEALSVRATFFVLGSRLERAPEVGRRMVAAGHEL
                     AVHGWEHDRPWLPRPGRDAAELARAAAAVQRITGQRPLWYRPPYGILTGGRWAAARRTG
                     LRPVLWSAWGRDWTASATPDGVVAEAASRLGPGGTLLLHDSDAYAAPGAWRVTLAALPH
                     LVAYCRGLGLEVGRLADHGHPGGGVPYGFPGPAG"
     misc_feature    9101..9115
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            9231..10025
                     /locus_tag="B591_RS01200"
                     /old_locus_tag="B591_01214"
     CDS             9231..10025
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (8-123). E-value: 2.2e-07. Score:
                     22.9. Matches aSDomain:
                     nrpspksdomains_B591_RS01200_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640254.1"
                     /locus_tag="B591_RS01200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01214"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_023421124.1"
                     /transl_table=11
                     /translation="MQISLDGRTALVTGSTQGIGAAIAAGLAGAGARVAINGRDAVRTE
                     EAVERLRRQVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDA
                     EWRRYFEVNVLTAVRLIRAYLPSIKERGWGRILNIASDSAVVIPAEMIQYGMSKTALLA
                     VSRGFAKEAAGTGVTVNSVIAGPTHTKGVEEFVYGLVDKDLPWDEAQRAFMREYRPQSL
                     IQRLIEPEEIAHLAVYLSSPLASATTGGALRVDGGYVDSILP"
     aSDomain        9255..9599
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_B591_RS01200_PKS_KR.1"
                     /evalue="2.20E-07"
                     /label="B591_RS01200_PKS_KR.1"
                     /locus_tag="B591_RS01200"
                     /protein_end="123"
                     /protein_start="8"
                     /score="22.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TALVTGSTQGIGAAIAAGLAGAGARVAINGRDAVRTEEAVERLRR
                     QVPGGELFSAPGDLATDEGLAEVLDRLPQTDILVNSLGIFGARPALEIDDAEWRRYFEV
                     NVLTAVRLIRA"
     CDS_motif       9261..9347
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_B591_RS01200_0001"
                     /evalue="4.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="B591_RS01200"
                     /protein_end="39"
                     /protein_start="10"
                     /score="13.0"
                     /tool="antismash"
                     /translation="LVTGSTQGIGAAIAAGLAGAGARVAINGR"
     gene            complement(10001..12583)
                     /gene="uppS"
                     /locus_tag="B591_RS01205"
                     /old_locus_tag="B591_01219"
     CDS             complement(10001..12583)
                     /EC_number="2.5.1.-"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="uppS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894521.1"
                     /locus_tag="B591_RS01205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01219"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="WP_023421125.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.3e-29, bitscore:
                     100.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.9e-20,
                     bitscore: 71.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLRLCLATALRYAVLEQVRNRLALALAVFFVPVWVGLAYTAMP
                     TAPVRFFLRAADQDVTVAGNVLTQLSGAVHALALIVGFMMFLAARRSAAFDHRLVTAGY
                     PRACLVLAKYLALLLACLLVAGYATAWICVFWRPEQPALLAAALGAGALTYGGAGIMLA
                     ALLRSELAGMFLVIMASFVDVSLQNPIANAGADSPVLRWLPTYGAMQSAVVAADTHHLP
                     WAHLGLALLWALATAAVGTAAFTLHTRSRLGDLRRAWRLPPLRHRVYRQAGVDDAELRA
                     GYETCRRLVRRSGQTDYAVTQLVPAPLRPLLWAIYGHGRVLDDLSDSGRADATERIDAW
                     VRAMEEDLARGSSTDPVRRALTHAVTTWDLPTEQLPASFATYRRDAAERPDFTSWEQWH
                     AYWHALSFPVGVTRLATLLGEATGTRLGPRDAEALRRWTDAFNLVDALRDLRQDACLGR
                     VALPLPVLAAHGVHLADLRTGGRTPQLDALVRELAVTAHGWLDDAAGLADRHPALAASW
                     RTLIRLQRLPLRALERGRPLSGGRRGAGSLRRALVLHTGRLRAARYWRRLGPVLAPPQG
                     APVPVPAPPVTPAVPGPRQAEPPLPPRPHAGGARPPGGLGDRVPRHVAIIMDGNGRWAA
                     ERGLPRPRGHGAGQAALRDVVYGALELGIPHLTLYGLSTENWKRPAAEVEEILRLLGEG
                     ADADREEVFARDVRLWWSGLPDGLPAGLLDALESTVRRTGHRRGLTLTLCVNYGGRGEI
                     TAAARELARDVAGGGLHPSAVTAPLFARYLHQPALPDVDLLIRTGGDHRLSNFLPWQTA
                     YAELVFLDTLWPEFDRTGLWRAVETYARRERRFGGLGEAAAQGRIEST"
     gene            complement(12580..13227)
                     /locus_tag="B591_RS01210"
                     /old_locus_tag="B591_01224"
     CDS             complement(12580..13227)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007819681.1"
                     /locus_tag="B591_RS01210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01224"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_023415731.1"
                     /transl_table=11
                     /translation="MTTTPAPPAAPPVLRLRDVHKRYGPRTVLNGADLDAAPGRLIGVV
                     GENGAGKSTLLRILAGELRADRGTVRLPATVGHCPQTVVLHHALTVAQHLRYFQVAYGL
                     PEPTRAWELLEELRFAGGPRDRTGTLSGGTRQKLNLAVALMHDPELLLLDEPYQGFDWE
                     TYLRFWEIARSLCERGRTVLVVSHMAHDADRLDALHRLAGGRLTPVRDGGRA"
     gene            complement(13294..14622)
                     /locus_tag="B591_RS01215"
                     /old_locus_tag="B591_01229"
     CDS             complement(13294..14622)
                     /EC_number="3.1.3.16"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010640258.1"
                     /locus_tag="B591_RS01215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01229"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_023421126.1"
                     /transl_table=11
                     /translation="MAGETEFPEGARADGLPAALSDPARLAAVRATGLLDTGPEPVFED
                     LATLAARITGAGRAFVTLVDEERSYWKSCVGVDVTGGRETPVRESFCYFLVGFAGDPFM
                     VEDAEHDPRTRDHPGIGPMKIGAWAGYPLLGPDGEVLGSFCVVDEAPRAWTAADRATLA
                     TLSRSASAEIHLRQSLAASQHAHRLSADLAHTLQRGLLPPALRPVPGLDAAAAYVPASA
                     SAHHDVTVGGDFYDLFHAAGPYYGAFLGDVCGKGVEAAQIISMARYTLRADAAEVLSPA
                     RLLTRLNTAMLAQEAPLFLTAVHATFRRTRSGAAGRVCLAGHPRPLVRRADGRVREVGR
                     PGTLLGVVEDVDLADTRFRLAPGDLLLLYSDGAYEARPAPGAPPEAAREPFGEADLHAT
                     LAATHGLDAAATVDRITGALADHHGGWASDDTALLALRVPERD"
     misc_feature    14600..14614
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.61"
                     /tool="antismash"
     gene            complement(14729..15712)
                     /locus_tag="B591_RS01220"
                     /old_locus_tag="B591_01234"
     CDS             complement(14729..15712)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894518.1"
                     /locus_tag="B591_RS01220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01234"
                     /product="ferric reductase-like transmembrane
                     domain-containing protein"
                     /protein_id="WP_023421127.1"
                     /transl_table=11
                     /translation="MQRPATPVPQEPDQAPDAAGRREGTPRLRGDLRAAVPDASAAVGV
                     TAAVFAFLWFRMEAGTSSTVAVMPFMDDPRAYWMYLLSQAFGWSALLWAWGTVMLGLVL
                     SGPRTARQPPRRTLERWHRTTSLTTTALMFAHALMFAAELVRHDSRPAWLTRLWSAFAD
                     SFVPGWYDSGTGQIAIPIGQAALYLAVPLGLLFYVRHRIGPRTWRRLHRFVLAVYVLSV
                     WHTLLYGTNVWYGEWPRTVLWLLQIPVALLLVVRLARPARRAERLGAPGRPGGPRLPEW
                     TARALGRLAAAAVVAGILAVVVSGHDGGRARPADPPASTPHDHGSG"
     gene            complement(15867..18884)
                     /locus_tag="B591_RS01225"
                     /old_locus_tag="B591_01239"
     CDS             complement(15867..18884)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894517.1"
                     /locus_tag="B591_RS01225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01239"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_023421128.1"
                     /transl_table=11
                     /translation="MLDTPQAVLDALRENDGRPHGLHRTVTAEELAEAAEAFDDPALLV
                     TALLELMAAYEFTGEHRKSPVVFARLLKLHETTPGAFSEWEDHQVNWRFKWVTTSLLQV
                     PDMPLATVHGWVDRMRERYEDAGHGLQPVAAMRYHVARHTGTGVPDAYDLWATRTRTRL
                     SDCEACETRHHALHQVFAGDDAGALDTWRPVLDDSVSCSDEPQMSQAHALLPLLRLGRT
                     DEARSHHLTGYRQVRGRTGMQEEVGLHLEFCALSRNSARGVEILAENRPLFEATGAPLA
                     RLGFLTGTEVLLALLVEEGHADTPVGGPPGRNRTAGELLAEVREEAGRLAAAFDTRNGT
                     TAVGDARRLRLDRRPLLDEPLPLGLRTALTGPAAVPAPAPVAAPAREIPGEFTELVREA
                     RRMAALGHPGDTPLWDRVAELAEAEGYAHDTLLGTWTRLRAELAEQRAHALYAEDRDRA
                     ARTAMEEAAELYEAAGMAWHALVARARALSWDVVITDGEGAEEAGENSGAARSARPELW
                     DALDAFQREAEQLLEKRIAAHDETGADPGPLPATGPPEGSATAEKYLTVLHCQVFAAYH
                     VALAGAPEIPAPDRERFDALRATLESEAGRLGVPHQRGAARMFAGDVAARLGDHAVAET
                     ELRAALKEIEASGRPWRGTRVRALLAQVLLCLGKPEEAAELLHQALAEAVRYEDTLFPM
                     APTYLLLGHAGTHTGDVTGAVRHFSEAATRFDREGEPDDAADARLQLADLLARTGRQAD
                     AVAVLESVVGDESAAALDERLLAQARLTLARGLRGLDEHLTAAEEFLRLADTVAGWEDG
                     AQTLTLVAAEAATSLALAGRWEAARTAYDRAFAAHAEAPNPPMLLETACEFARLTMDAH
                     GAEAAEEALRRLADADALYAAVPEDDEDFVHWFARGSIHYRRARVLAQADRFAEALPEA
                     EAAVAAFADGGTDGEERRAEAVRIAALVESHGLGRTQAAVARLDEAAARCERAGLSEAA
                     QILTAVREDLAAGAAD"
     gene            complement(18885..20735)
                     /locus_tag="B591_RS01230"
                     /old_locus_tag="B591_01244"
     CDS             complement(18885..20735)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0051082 - unfolded protein binding
                     [Evidence IEA]"
                     /GO_process="GO:0006457 - protein folding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018894516.1"
                     /locus_tag="B591_RS01230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01244"
                     /product="HSP90 family protein"
                     /protein_id="WP_023415734.1"
                     /transl_table=11
                     /translation="MLHSESSHSFQVDLRGLVDLLSHHLYSSPRVYLRELLQNAVDALT
                     ARQAADPGAPAAITVRTGETLTVTDTGIGLTEADVHRFLATIGRSSKRSADGGLDGAGL
                     ESARGEFIGQFGIGLLACFVVADEITVVSRHAADPGAPTVEWRGHSDGRYTIRTLPASA
                     MPEPGTTVRLTPRADNAEWTTPERVTELARHFGGLLKYEVTVVDPRGTATRVNDTPPWE
                     RPHGSPLARREALTAYCRTTFDFTPLDTIELDLPAAGLRGVAYVLPTAVSPAQRAGHRV
                     HLKGMLLTDKAPELLPDWAFFVRCVVDTTSLRPTASREALYEDGTLAAVRDALGQRIRD
                     WLTGLAASDPALLHRFIDTHHLAVKALARYDDELLRTVLPWLPFETTDGNVTLEEFARN
                     HPTVLVTRSVEEFRQVAPIASAAGLGVVNGGYTYDRDLVHRLPEIRPGSSVTDLDPATV
                     TAHLDAVDPSAELRAAAFLALARETVGAHDCDVVLRDFQPVTAPALLLDNREARHERTR
                     SSLASESDGLWADILGSLRDETPRAQLVLNHLNPLVRQALTITERGLATTAAEALYGQA
                     LLLSRRPLRASESALLNRAFIGLLTHAMHPAGPAEPRKDA"
     gene            complement(20867..21841)
                     /locus_tag="B591_RS01235"
                     /old_locus_tag="B591_01249"
     CDS             complement(20867..21841)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008415332.1"
                     /locus_tag="B591_RS01235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="B591_01249"
                     /product="hypothetical protein"
                     /protein_id="WP_023421129.1"
                     /transl_table=11
                     /translation="MALLRGAGSSLRRWIGRSTAEVDEDQGEPEIGRIREAAEAADWAA
                     VRDQLTERPESEDRTWLITAVARTANVENWIPQAVEAEPDSALPLLVAGARHVNWGWEA
                     RTGARAEHVSRDQFQVFHNRLRTAEKWLYAAAEREPEWVSPWYFLQMSGRGLQVGQTVA
                     RRRFEAAVRRHPHHLGAHQQQLQQLCDKWGGSHEEMHAFASQALREAPAGSMLGQLVAL
                     AHIEQWLALDSGADAEYLGQPEITASLTEAAERSIWHEDFAYGQGWLQVYNTFAMAFSL
                     TGDRDLAKLCFDGTGGIVTAFPWNYLDADPAAAYRENRAAAGR"
     misc_feature    complement(21893..21909)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.05"
                     /tool="antismash"
     misc_feature    complement(22188..22204)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 18.65"
                     /tool="antismash"
ORIGIN
        1 gccgtggccg ccagggcggt tgtcgcggac cagaggaaga gggcgggcca gacgtaggtg
       61 atctgcgcca gggttcccgc gcggcccatc agcaggccga agaggtccgc gaggccgagg
      121 aggagcaggc cgggaaggag gtacggggcg aggcgcgcgg ccgggcgcag ggggccgcgc
      181 caggggcggc gggcccaccg tcccgcgcgc aggacgccgc gtaccgccag tcccagggcg
      241 agcagggaga ggacgccgag gaccgggtcg gcggtgtcgg tgaagggggc gcggtccgcc
      301 ggggtccggc cttcggcgag gtcgacgagg ccgtcgacga ggagcggggc gtcgtccccg
      361 gagaccatgc cggtgttggt gaccaccgcg atccccacgc cggaggcggg cagcagcgtg
      421 gccatggagt tgtgggtgaa gaggctcccc gtgtgctcga tccgcagcgg ccacccctgc
      481 tcctcccgcc ggttccagcc catcgcgtac gtctggccgg gcggcggggt gcgggtgagc
      541 cggaccgctt cggcgggggc ggcgcggcgg ccggtggcgg aggtcccctc ggtgtgctgg
      601 gcgatgagcc atttccccag gtcgtctgcg gtactgacga cgccgaagcc accggcggtg
      661 aagaggcggg gatgggcgcg ttcgatcgtc cgcccgtagg cgcggacgta cccccgggcg
      721 ccgtcgggca tgtcggcggt ggtgtcgacg gtcccggtgc cggtcatgcc gagcggcgcg
      781 aagaggctcc ggcgcaggtg ttcggcgtac ggggtgccgg tggcggtctc gacgaggcgc
      841 gcggcgacgg cgtagttggt gttgtggtag tgccaggccg tgccggggtc gctggcgagc
      901 cgcgtgccgt ggagggcggc gaccgcggct ttcagggtgc gcggctgcgg cagggcgaga
      961 tcggggtggg tcgagtcggc catccccgag gtctggtcga ggagttggcg tggggtgatc
     1021 cgggcggcgc gggcgtcgtc gggggcgaac tcggggagct ggtcgcggac gggcgcgtcg
     1081 aggtcgacgc ggccttcctc ggcgagggtg gtcaccgcca gcgccgtcat cgccttggag
     1141 agggaggcga ccgggaccgg ggtccgggcg gtcatcggct ctcccgccgc ggtgtgcccg
     1201 tacccggcgg cgaggacgac acggtcgccc cgggtcacgg tgaccgtcgc gccggggact
     1261 cccgtgcggg ccagatggtc gcggacgaag cggtcggcgg tggcccggtc gagaaccggc
     1321 gcctcaggcg gggcggcctg ggccgggacc gggacgagga gcggcgcggc ggacagcagg
     1381 gcggctgcgg cggcccggag aagcgaacgc cttcgccggg gccggagtgg gggcgtggtc
     1441 atgcccgaga gccaaccggc cgcagggggc cgggcgcagt ggtggcactg ggacggaaaa
     1501 ggtggtgcgg gcactaccga cccggcggcg cgggctccgt actgtcggtc catgcacgcg
     1561 cgaacggcct ggcaggctct ggcccatcac cctctcgcct tcctcgccac gctctggccg
     1621 tggcgtgcgc tggcctatct gctctccggt gtgggagtcg gggcgctcac cctggtggtg
     1681 ctggtggccg ggctgctgac ggggctggtg ctgctgccgg tcggggtggg ggccgccgtc
     1741 ctgctcgccg tggtcctcgg cggcggtgtg gtcgcgcggg tggagcggtg gcggttgcgg
     1801 ctggtcgacc tcgaccctgc ggccacggac caccgggcgc cggacgcgcc cggtgcgcgg
     1861 gcgtggctgc ggacccggtt gcgggaccgg ctgacctggc gggagctggg gttcacggcg
     1921 gtctccatga cggcgctgtg gtggatggac ctgctcgtcc tcgccttcgc cctggccctg
     1981 ccggtgctgt gcgtgacggc gccgctggac gacccggacg cctggccgtg ggtggtgatc
     2041 ggcctcgcgc tgctgccggc ggcgccttac accgtcaccg gctgggccgg ggcgcgggcg
     2101 gcgctgaccc ggctggtgct ggcaccgagg gacgccgaac tgaccgaggt ccgtgcctcg
     2161 cgggccaggc tggtcggggc cttcgacgcc gagcggcgcc ggatcgagcg ggatctgcac
     2221 gacggggcgc agcagcggct ggtgtcggtc aacgtgatgc tggggctggc ccgtctcgac
     2281 gccgggcccg actcggctct cggccgccgg ctggacgccg tacagggcga gttgaggacg
     2341 gccgtcggtg agctgcgcga cctgagccgg ggcgtccatc cccgtgccct gaccgatcag
     2401 ggtctggcgg cggccctcac caacctcacg gcccgctcgc cgctgccggt caccgtcgac
     2461 gtggctcttc cggggccgct gcccgcgtcc gtcgcgagca cggcgtactt cgtggtcgcc
     2521 gaggcgctgg ccaacgcgac caagcacagc ggcgccgggt gtgccgaggt ccgggcccgg
     2581 ctgcgtaccg acacgctggt gctgaccgtc cgggacgacg ggagcggggg cgcggacccc
     2641 gccgggcggg ggctgacggg actggcggac cgggtggcgg cggcggacgg catactgcgg
     2701 ctgtccagcc cgtccggcgg gcccaccctg ctccacgtgg agatgccgtg tcactgaagg
     2761 tcgtggtcgc cgaggactcg gcgctgatgc gggagggcct ggtgggcgtg ctgacccgct
     2821 tcggccacca ggtgtgcgcg gcggtggggg acgcggacgc gctcctcgcg gcggccggcg
     2881 agcaccgtcc cgacctcgtc ctcaccgaca tccgcatgcc gccgggccag ggtgacgacg
     2941 gcctgcgcgc cgccgtcgcg ctccgccgcg accacccgga cctgccggtc ctcgtcctca
     3001 gccagtacct ggagcagtcc tacgccgccc atctgctcga cctcggcgac cagcgcggcg
     3061 tcggctacct gctgaaggac cgggtggcgg cggtcaccga cttcgcggac accgtggtcc
     3121 gggtggcggg cggcggcacg gtgctggacc cggaggtggt acggcagttg ctgcggcgcc
     3181 gcgaggaccc gctgagccgt ctcacgcccc gggaacggga ggtgctggcg ctgatggcgg
     3241 agggccgctc caacgcggcc atcgcccggg ccctgcacgt ctcggtggcc gctgtgaaca
     3301 agcacatcgg cagcatcctg caacgcctcg gcctgccgct ggacggtgac gcccaccggc
     3361 gggtcctggc ggtgctggcc tatctgcgga gctgacctcc cgccgggtca ggcgggggcc
     3421 gccagccggt cgaggcgggc gcggtgcgcg gccggcagcc ggaggcgtgc ggcggcggtg
     3481 ttctcctcca ggtgcgccgg gtcggcggtg cccgggatcg ggaggatcac cggggagtgg
     3541 ccgaggagcc aggcgaggga gacctgggtg gcggtggcgc cgagttcggc cgcgaccgag
     3601 gccacctccg cgtgggcgcc ggagtcgccc caggcggccg gccgccacgg gaggaaggcg
     3661 atgcccgccg acgcgcaggc ggcgaggacg ggttcgtgct cgcggtccag caggttgtac
     3721 cggttctgca cgcccgcgat ctcggtggtc cgccgcgcct cgtcgagttc gccgacggtg
     3781 acctcggaga gcccgatgtg gccgatcttg ccctcctcgc gcagctcccg cagggcgccg
     3841 agctggtcgg cgagcgggac cgaggggtcg atgcggtgca gttgcaggaa gcctatgtgg
     3901 tcgcggcgca gccgccgcag tgcctgctcg acctggtcgc gcagggcctc ggggcgggcg
     3961 tcgtggtccc actcccccgc cgccgaccgg gccatgccca ccttggtcgt gatcagcagg
     4021 tcgtcggggt aggggtgcag ggcctcggcg agcagctcct cgttggcgcc gccgccgtac
     4081 atgtgggccg tgtcgatgag ggtgacgccc agttcgacgg cgcgccgggc gacggccagc
     4141 gcgttcttcc gctcagggcc gggttccgtc ggcaggtgca tcgccccgaa cccgagcctc
     4201 ccgacctcca gctccccgcc gatccgccac acgtccgttg tcatacgcca ctcccccgcc
     4261 ggcagaagtg gccacgctag caatgcggtt gaggaatggt ccgttcctca gtccacctcc
     4321 aggacgatct tcccggtggt ccgcccggtc tcgccgagcc ggtgggcggc ggctgcctcg
     4381 gccagcggga aggtcgcctc gacgcgcggg cggagagccc ctgcggcgac caggtcggcg
     4441 acggcgttca tgccggcgtg gtcggcctcg accagcatcg tcgcggtgcg cacgccccgc
     4501 tcggcggcgc gtgccgcctc ctcggccgaa ccgccggaga gcagggagac cagggtgccg
     4561 ccggggcgca gcaggccgac cgaccgggcg cgggtctcgc cgccgagcgg gtcgagcacc
     4621 atgtcgacgc cgtcgaccgc ctcggcgaca tccgtggtgc ggtagtccac cacctcgtcg
     4681 gcgcccagtt cgcgcagcag gtcgtgcttg ggggcgctgg ccgtgccgat gacgtacgcg
     4741 ccgtgcgcct tggcgatctg tacggccaca tggccgacgc cgcccgccgc cgcgtggatc
     4801 aggacgcgct gtccggggcc gatcccggcg gtgtcgatca gtgcctggta ggcggtgagg
     4861 gagaccagcg ggagcgcacc cgcctggacg tggtcgatca ccgtgggctt acgggtgaag
     4921 gcgcgggcgg gcccgacgac gtactcggcg tgcgagccgg agccgtgcgg gtagggcagc
     4981 atgccgaaga cctcctcgcc gggtgcgaag agggtcaccc cgtagccgac ggcctccacc
     5041 acgccggaga cgtcccagcc gaggatgagc gggagccggt cgacgaagcc cgcctgcgcg
     5101 cggtgcttcc agtcggtggg gttgaccccg gcggcgcgga cggcgaccag gatctctccc
     5161 ggtcccggct cgggcctcgg cacccgggtc tcgtggagga cctcggggcc tccgtggctc
     5221 tcctggatga tggcgcgcat cgtggctgct tcctgcgtca tgggtccagc ctcgcggacg
     5281 gccgcgttcc acaccacgcc gggccggtgc gcgggtgaac cggtcagccg gtgggccggg
     5341 tcagcagctc tgcggcgtcc gccacgaagg cggcccggcc ccgctccacc tggccggtgc
     5401 gcaccggccc cgggcagagg agccgccgga cgcccgccag cagttcgtcc gggtcgtggg
     5461 cgtacgtgct gagtccggcg gcggccatgc tccgcgcccc gtcgcggccg tggccgggca
     5521 gcggccgcca ggcgagaacg ggcacaccgg cggcgagggc ctgggccgcc gtctgcccgg
     5581 cggcgttgtc gaccaggagc cgggcggcgc ccatcagccc cgtcatgtcg tccgtccagc
     5641 cgagggcgac ggcgccgggg acgcgggcgg cccggcggcg cagccgctcg tcccggccgc
     5701 agagcaggac gggccggcag ccgtgcgcgg cgaggagccg ggcggtgcgc acggtccggg
     5761 tgccgacgcc ccacgcgccg gtggagagca ggacgggcgg cggcccgggt acgggaccgt
     5821 gtgggtgcgg gccggccgcc cggtggaact ccggggcgac gaccggtccg gagacggcgg
     5881 ccgggcggcc ggtggcggca cgggccgcct ccgcgccctg cgcggtgagg cacacgtaga
     5941 ggtcgttgcc ggggtgcagc cagccgcggt ggacggcgaa gtcggtgacg aagaccgagg
     6001 cggggacggg caggacgcct tcggcgcgga gcctgccggt gatctgcgcg gcgaggtgga
     6061 aggtggggac gagcaggtcc gggcggaagg cgtggacccg gcgcagcagc cgggcgcggg
     6121 ccgtcgcggc caggggcgcg ctgccggggc ggtgcccgtc gcccggggag aggaacaggg
     6181 cgtagaccgc ggcgtacagg gcgggggcgt gccgcaccgt cgcccggtag caggcgcgca
     6241 ggaccgtccc cgtgccgggc ggcaggaggg tgaggacgtc gcagagctcg gtggtggcgc
     6301 ccccggcccg gagtctgcgg gccagttcgc cgctgaccgc gtcgtgcccg gcacccatgc
     6361 tcgcgccgag cagcaggacc cgcaggctgc ccatgctcct cccctcgccc ggccggttga
     6421 ctcgtccctc gcttgcatgc cgcgtccggg cgggggcgca atcggcccgt tcgggtgacc
     6481 cggcggcggc gtgccccggc gttggacgag cggttcgccc gccgagcacg gaagctgagg
     6541 gccaggcgtg ccgcgaggaa ggggactggc atgggcgagg agcgggcggc atgacgcggc
     6601 gtcccgaacc cgggggcgtg ccccggcgga ccgtgctggt cacgggtgcc tcctcgggca
     6661 tcggcgccgc ggtggcgcag tccctgcacg ccgacggacg gtggcggctg ctgctcagcg
     6721 gccgcgacgg gcagcggctc gcggcggtcg cggagcggac cggcggcgag gcgatccgcg
     6781 ccgacctggc ggccgagggc ggctgcgagc acctggcagc agaggcggtg gcccgtgccg
     6841 gtcgcgtcga cgcgctggtg gccggggcgg ggatcggctg ggcgggtccg ttcgtgacga
     6901 tgccgccgga ggagatcgac cgcgtcctga ccgtcaacct cacctccacg ctgaggctgg
     6961 tgcggctgct gctgccctcg atggtggcgc gcggtacggg gcggctggtg ctgatcgggt
     7021 cgatggccgg ctgggtcggg gtgggggacg aggcggtcta ctcggcgtcc aagggcgccc
     7081 tgctgacctt cgcggacagc ctgcgccggg agctggccgg cacccgggtg cgcgtctcgg
     7141 tggtgtcgcc gggcgcggtg gacacgccgt tcttcgcccg gcgcggtacc ccgtaccacc
     7201 ggcgccgccc ccgcccggtc tccgccgacc gggtggcccg cggggtgcgg gaggcactcg
     7261 tgcgaggccg ggagaacgtc ctggtgccgg ggtggctggc gctgccggcg cggctgcacg
     7321 gggcggcgcc gggactgttc ggggccgtgg ccgaccgtgc cgacccgcac cgcggtgact
     7381 gaggcggggg cgcgccggtg accgtgctga cggtggtgct ggcgcttctc gcggcgctcg
     7441 gcaacgcggc cgcctcggtg ctccagcgcc gcggcaccac gcaggtggac ggcgtcgggg
     7501 cggccgtcgc ccggtggtgg tcctgggcca cgcggctgct ccggcgccgg gtgtggctgt
     7561 ggggcgcggc gctgctggcg gtctccgggc tctgccaggc ggcggcgctg gcggccggtc
     7621 cgctcgccgt ggtgcagccg gtgatgacca ccgaactcct cttcaccatg gtcatcggca
     7681 gtgccgtctt ccgccgccgg ccggacgtca ggacctggtg ggcgtttgtc gcgatggccg
     7741 ccgggctcgg agccttcatg gcgctgctct cccccaccgg cgggggctcg acggtgccgg
     7801 ggtcgcggtg gctgtggtcg ggagtgctgc tggcggtcct gatgctggta ctgacggtgg
     7861 tggcctggcg gctgccgccc gcgccggccg ccgcggtcct gggcaccgcc accgcgatcg
     7921 gcttcgccgg aaccgccgcg ctggtcaagg acgccctggg acgggtgccg gacggcggcc
     7981 tcggggcgct ggccaccacc tggcaggcgt acgcggcggt cgtcgtgggg ctggggagtt
     8041 tcctgctgct gcaactcacg ctgcgggcgg ggccgctggt ggcctcgcag ccggcgatga
     8101 cgctgggcga cgccttcctc agcatgctgc tgggccgggt cctcttcggc gaggagctga
     8161 ccctcggggt gcggctggtg ccggaactgc tggcgctcgc gctgctgatc gcgggcaccg
     8221 tgcagctggc ccgttctccc ctgctgacct cgaccgacgg aatggagcgg ccgtggtgag
     8281 cgcgccgggc acggccgccg gggcgctggc cgggggggcg ctggccgtcg ccgcgtggca
     8341 catcggtccg gcggcgacct ggctgcccgg cctccgtacg gcgtacttcc ccgggctcga
     8401 cggacggggg tcgcccggcc aggtggcgct caccttcgac gacgggccgg acccgctgag
     8461 caccccgcac ttcctgcggg cgctggaggc gttgtcggtc cgggccacct tcttcgtcct
     8521 cggcagcagg ctggagcgcg ctccggaggt gggccggcgg atggtggcgg ccgggcacga
     8581 gcttgcggtg cacggctggg agcacgaccg cccgtggctg ccccggcccg gccgggacgc
     8641 ggcggaactg gcccgggcgg cggccgcggt gcagcggatc acgggacagc ggccgctctg
     8701 gtaccggccg ccgtacggca tcctcaccgg cggccgctgg gccgccgccc gccggaccgg
     8761 gctgcgcccg gtgctgtggt cggcctgggg ccgcgactgg accgcctccg cgaccccgga
     8821 cggcgtcgtc gccgaggccg cctcccggct ggggcccggc ggcacactgc tgctccacga
     8881 ctcggacgcg tacgcggctc cgggtgcctg gcgggtgacc ctggcggcgc tgccgcatct
     8941 ggtcgcgtac tgccgggggc tcgggctgga ggtgggccgt ctcgcggacc acgggcatcc
     9001 gggcggcggg gtgccgtacg ggtttccggg gcctgcgggg tgaggacgcc cgccgggccg
     9061 gagccggtct cccgttgcgc cgtcccgcag gacagggcgt atcaggggtg gccatcatgg
     9121 gcaggcgatg cggcgcaccg ccttgcccgt ggcggcgtcg gccgccgggt gcgcggtgag
     9181 gccggtccgc agtggcggcc gtaccgacga cgcgaggagt tccgagcagg atgcagatct
     9241 ctctggacgg caggaccgcc ctggtcaccg gttccaccca gggcatcggc gcggcgatcg
     9301 ccgccggcct ggcgggggcg ggcgcacggg tggcgatcaa cgggcgtgac gccgtacgca
     9361 ccgaggaggc ggtcgagcgg ctgcggcgcc aggtgccggg cggggagctg ttctccgcgc
     9421 ccggggacct ggccaccgac gagggcctgg ccgaggtgct ggaccggctg ccgcagaccg
     9481 acatcctcgt caacagtctc ggcatcttcg gcgcgcgtcc cgcgctggag atcgacgacg
     9541 ccgagtggcg ccgctacttc gaggtaaacg tcctgacagc cgtccggctg atccgcgcct
     9601 acctgccgag cataaaggag cgcggctggg gccggatcct gaacatcgcc agcgactcgg
     9661 cggtggtgat cccggccgag atgatccagt acggcatgtc caagaccgcc ctcctcgccg
     9721 tctcccgcgg cttcgccaag gaggccgccg ggaccggcgt caccgtcaac tcggtgatcg
     9781 ccggccccac gcacaccaaa ggcgtggagg agttcgtcta cggcctggtc gacaaggacc
     9841 tcccctggga cgaggcccag cgcgccttca tgcgcgagta ccgcccgcag tccctcatcc
     9901 agcggctgat cgagcccgag gagatcgccc acctggccgt ctacctcagc tccccgctgg
     9961 cctccgcgac gaccggcggc gccctgaggg tggacggcgg ttacgtggac tcgatcctgc
    10021 cctgagccgc cgcttccccg agcccgccga agcggcgctc acggcgggcg tacgtctcga
    10081 cggcccgcca caggccggtg cggtcgaact cgggccagag ggtgtcgagg aagaccagtt
    10141 cggcgtaggc ggtctgccag ggcaggaagt tggagaggcg gtggtcgccg ccggtccgga
    10201 tcagcaggtc gacgtcgggc agcgcgggct ggtgcaggta gcgggcgaag agcggtgccg
    10261 tgacggcgga ggggtggagg ccgccgccgg ccacgtcgcg ggcgagttcc cgggcggccg
    10321 cggtgatctc gccccggccg ccgtagttga cgcagagggt cagcgtcagg cccctgcggt
    10381 ggccggtgcg ccggaccgtg ctctccagcg cgtcgaggag tccggcgggc aggccatcgg
    10441 gcagaccgga ccaccacagc cgtacgtcgc gggcgaagac ctcctcgcgg tcggcgtccg
    10501 cgccctcgcc gaggagccgg aggatctcct ccacctcggc cgccgggcgc ttccagttct
    10561 cggtggagag cccgtacagg gtcaggtggg ggatgccgag ttccagggcg ccgtagacca
    10621 cgtcccgcag cgccgcctgg cccgccccgt ggccgcgcgg cctgggcagg ccccgttcgg
    10681 cggcccagcg gccgttgccg tccatgatga tcgccacgtg ccggggcacc cggtcaccca
    10741 gcccgcccgg cggcctcgcc ccgccggcgt gcgggcgcgg cggcagcggg ggttcggcct
    10801 ggcgtgggcc cggcacggcc ggggtgacgg gcggcgcggg cacggggacg ggtgcgccct
    10861 gcggcggcgc gaggaccggg ccgagccgcc gccagtaccg ggcggcgcgc agccggccgg
    10921 tgtgcaggac cagggcgcgc cggaggctgc cggcgccccg gcggccgccg gagagcggac
    10981 ggccgcgttc cagggcccgc agtgggaggc gctggagccg gatgagggtg cgccaggagg
    11041 cggcgagggc ggggtggcgg tcggcgaggc cggcggcgtc gtccagccag ccgtgcgcgg
    11101 tgacggccag ctcccgtacg agagcgtcga gttgcggcgt acggccgccc gtgcgcaggt
    11161 cggcgaggtg cacaccgtgc gcggcgagga ccggaagggg gagggcgacg cggcccaggc
    11221 aggcgtcctg gcgcaggtcg cgcagggcgt cgacgaggtt gaacgcgtcg gtccacctcc
    11281 gcagcgcctc ggcgtcgcgc gggccgaggc gggtcccggt ggcctcgccg agcagggtcg
    11341 cgagacgggt gacgccgacg gggaagctga gggcgtgcca gtaggcgtgc cactgctccc
    11401 aggaagtgaa gtcggggcgt tcggcggcgt cccggcggta ggtggcgaag gaggcgggca
    11461 gctgctcggt gggcaggtcc caggtggtga cggcgtgggt cagcgcccgc cgcaccgggt
    11521 cggtgctgga gccccgggcg aggtcctcct ccatcgcccg cacccaggcg tcgatccgtt
    11581 cggtggcatc cgcccggccg ctgtcggaga ggtcgtccag gacccggccg tgcccgtaga
    11641 tcgcccacag cagcggccgc agcggggcgg ggacgagctg agtgacggcg tagtcggtct
    11701 ggccggagcg gcggaccagg cggcggcagg tctcgtaacc ggcgcgcagc tccgcatcgt
    11761 ccacgcccgc ctgccggtag acgcggtggc gcagcggggg caggcgccag gcgcggcgca
    11821 ggtcgccgag gcggctgcgg gtgtgcaggg tgaaagcggc cgtgccgacg gcggcggtgg
    11881 ccagggccca caggagggcg aggccgaggt gggcccaggg caggtggtgg gtgtcggcgg
    11941 cgaccacggc ggactgcatg gcgccgtagg tgggcagcca gcgcaggacg ggactgtcgg
    12001 cgccggcgtt ggcgatcggg ttctggaggc tgacgtcgac gaagctggcc atgatgacca
    12061 ggaacatccc ggccagttcg ctgcggagca gcgcggcgag catgatgccg gcgccgccgt
    12121 aggtgagcgc gcccgcaccg agggcggcgg ccagcagggc cggctgctcg gggcgccaga
    12181 agacgcagat ccaggcggtg gcgtagccgg cgacgaggag gcaggcgagc agcagggcca
    12241 ggtacttggc gaggaccagg caggcgcgcg ggtagccggc ggtgaccagg cggtggtcga
    12301 aggcggcgga gcggcgcgcg gccaggaaca tcatgaagcc gacgatcagg gccagcgcgt
    12361 ggacggcgcc ggagagctgg gtgaggacgt tcccggcgac ggtgacgtcc tggtcggcgg
    12421 cgcgcaggaa gaaccgcacc ggcgcggtgg gcatggcggt gtacgcgagg ccgacccaga
    12481 cggggacgaa gaagacggcg agcgcgaggg cgagccggtt gcgtacctgt tcgaggacgg
    12541 cgtaccgcag ggccgtggcg aggcagagcc gaaggcgcgt catgcgcggc ccccgtcgcg
    12601 cacgggggtg aggcggccgc cggccagccg gtgcagggcg tcgaggcggt cggcgtcgtg
    12661 cgccatgtgg gagacgacca ggacggtgcg gccccgctcg cagagggagc gggcgatctc
    12721 ccagaaccgc aggtaggtct cccagtcgaa gccctggtag ggctcgtcga ggaggaggag
    12781 ttcggggtcg tgcatgaggg cgacggcgag gttgagtttc tgccgggtgc cgccgctgag
    12841 ggtgccggtc cggtcccggg ggccgccggc gaaccgcagt tcctccagga gttcccaggc
    12901 gcgggtgggc tccggcaggc cgtaggcgac ctggaagtac cgcaggtgct gggcgacggt
    12961 gagggcgtgg tgcaggacca ccgtctgcgg gcagtgtccg accgtggcgg gaaggcgcac
    13021 cgtcccccgg tcggcgcgca gttcaccggc gaggatgcgg agcagggtgc tcttgcccgc
    13081 gccgttctcc ccgaccacgc cgatcagccg gccgggcgcg gcgtccaggt cggccccgtt
    13141 cagcacggtg cgcgggccgt agcgtttgtg gacgtcgcgg aggcgcagca cgggcggggc
    13201 ggccggcggc gcgggtgtgg tcgtcatggc cggtgaacga ggcggggcgg gttcccgtac
    13261 gggtggtgtg gaaggccgtg ggggcgcggg cggtcagtcg cgctcgggta cacgcagcgc
    13321 gagcagggcg gtgtcgtcgc tggcccagcc gccgtggtgg tcggcgaggg cgccggtgat
    13381 ccggtcgacg gtggcggcgg cgtccaggcc gtgggtggcg gcgagggtgg cgtgcaggtc
    13441 ggcctcgccg aagggctcgc gggcggcctc ggggggtgcg ccgggggcgg ggcgggcctc
    13501 gtaggcgccg tcggagtaga ggagcagcag gtcccccggg gccaggcgga agcgggtgtc
    13561 ggcgaggtcc acgtcctcca cgacgcccag cagggtgccg gggcggccca cctcgcggac
    13621 ccggccgtcg gcgcggcgga ccaggggccg cgggtggccc gcgaggcaga cgcgtccggc
    13681 ggcgccggag cgggtgcggc ggaacgtggc gtggacggcg gtcaggaaga gcggggcctc
    13741 ctgggcgagc atggcggtgt tgaggcgggt cagcagccgc gccggggaga ggacctcggc
    13801 ggcgtcggcg cgcagcgtgt agcgggccat ggagatgatt tgggccgctt cgacgccctt
    13861 gccgcagacg tcgccgagga aggcgccgta gtaggggccg gcggcgtgga agaggtcgta
    13921 gaagtcgccg ccgacggtga cgtcgtggtg ggcgctggcg gaggccggga cgtaggcggc
    13981 ggccgcgtcg agtccgggga cgggccgcag ggcggggggc agcagccccc gctggagggt
    14041 gtgggcgagg tcggcggaga ggcggtgggc gtgctgggag gcggcgaggc tctgccgcag
    14101 gtggatctcg gcggaggcgg agcgcgagag ggtggcgagg gtcgcgcggt ccgccgcggt
    14161 ccaggcgcgg ggcgcctcgt cgacgacgca gaaactgccc agcacctcgc cgtccgggcc
    14221 gagcagcggg tagccggccc aggcgccgat cttcatcggc ccgatgccgg ggtggtcgcg
    14281 ggtgcgcggg tcgtgctcgg cgtcctcgac catgaacggg tccccggcga acccgacgag
    14341 gaagtagcag aagctctccc ggaccggggt ctcccggccg ccggtgacgt cgacgccgac
    14401 gcacgacttc cagtacgagc gttcctcgtc gaccagggtg acgaaggcgc gtccggcgcc
    14461 ggtgatccgg gcggccaggg tggccagatc ctcgaagacc ggctcgggac cggtgtccag
    14521 caggccggtg gcgcggaccg cggccaggcg tgcggggtcg gagagcgcgg cgggcagtcc
    14581 gtcggcccgc gctccctcgg gaaactcggt ctcaccggcc acccgacccc tgccttccac
    14641 gccgctgcgg ctctaggaaa aggctaggcc cccctgcgcg gggccaccac cgcgggcggc
    14701 gccgggggcc gctgccccgg cgcgtcgctc acccggagcc gtggtcgtgc ggggtgctcg
    14761 ccggcgggtc ggcggggcgg gctcggccgc cgtcgtgacc gctgaccacc acggcgagga
    14821 tgccggcgac gaccgcggcg gccgcgagac gcccgagcgc gcgggcggtc cactccggca
    14881 gcctgggccc gccggggcgg ccgggggcgc cgagccgttc ggcgcggcgg gccgggcggg
    14941 cgaggcgcac cacgaggagg agggcgaccg ggatctggag gagccagagc acggtgcgcg
    15001 gccattcgcc gtaccagacg ttggtgccgt acagcagggt gtgccagacg ctcagcacgt
    15061 agacggcgag gacgaagcgg tgcaggcggc gccaggtgcg ggggccgatg cggtggcgta
    15121 cgtagaagag caggcccagc gggacggcga ggtagagggc ggcctggccg atggggatgg
    15181 cgatctggcc ggtgccggag tcgtaccagc cgggcacgaa ggagtcggcg aaggcggacc
    15241 agagccgggt gagccaggcg gggcggctgt cgtggcggac cagttccgcc gcgaacatca
    15301 gcgcgtgcgc gaacatcagc gcggtggtgg tgaggctggt ggtgcggtgc cagcgctcca
    15361 gggtgcggcg gggcggctgc cgggcggtcc gggggccgga gagcaccagg ccgagcatga
    15421 cggtgcccca cgcccagagc agcgcggacc agccgaacgc ctggctgagc aggtacatcc
    15481 agtaggcgcg cgggtcgtcc atgaacggca tcacggcgac cgtcgaggag gtgcccgcct
    15541 ccatgcggaa ccagaggaag gcgaagacgg cggcggtgac gccgaccgcg gcggaggcgt
    15601 cggggacggc ggcgcgcaga tcgccccgga ggcgaggcgt cccctcccgt cggccggccg
    15661 cgtcgggggc ctggtccggc tcctgtggta cgggcgtggc ggggcgctgc atgcgtcggc
    15721 ctttcctcgc ggcgggtaac cggcgtgact cgcgtgcaca gtgtggcgcc ccgcgcgccg
    15781 gctgccgaga gcggaaccgg ccgacatgat ctggccgccg ggccgggcgg cgcggggtgc
    15841 gcgccgcccg gcccggcgga cggggctcag tcggcggcgc ccgccgcgag gtcctcccgg
    15901 acggcggtga ggatctgtgc cgcctcggac aggcctgcgc gctcgcaccg ggcggcggcc
    15961 tcgtcgagcc gggccaccgc cgcctgggtg cggccgaggc cgtggctctc gaccagggcg
    16021 gcgatgcgga cggcctcggc gcgccgctcc tcgccgtcgg tgcctccgtc ggcgaaggcg
    16081 gcgacggccg cctcggcctc gggaagggcc tcggcgaagc ggtccgcctg ggccaggacg
    16141 cgggcccgcc ggtagtggat gctgccccgg gcgaaccagt ggacgaagtc ctcgtcgtcc
    16201 tcggggacgg ccgcgtacag cgcgtcggcg tcggcgagcc ggcgcagcgc ctcctcggcc
    16261 gcctcggcgc cgtgcgcgtc catggtcagg cgcgcgaact cacacgccgt ctccagcagc
    16321 atcggcgggt tcggcgcctc ggcgtgcgcg gcgaaggccc ggtcgtaggc ggtgcgcgcc
    16381 gcctcccagc ggccggccag ggccagcgag gtggcggcct cggcggcgac cagggtgagg
    16441 gtctgcgcgc cgtcctccca gccggcgacg gtgtcggcca gccgcaggaa ctcctcggcg
    16501 gcggtcaggt gttcgtccag cccgcgcagg ccccgggcga gggtcaggcg ggcctgggcg
    16561 agcagccgtt cgtcgagtgc ggccgccgac tcgtcaccca cgacggactc caggacggcg
    16621 accgcgtcgg cctggcggcc ggtacgggcg aggaggtcgg cgagctggag ccgggcgtcg
    16681 gcggcgtcgt cgggctcacc ctcgcggtcg aagcgggtgg ccgcctcgga gaagtggcgt
    16741 acggctccgg tgacgtcgcc ggtgtgcgtc ccggcgtggc cgagcagcag gtacgtgggg
    16801 gccatgggga agagcgtgtc ctcgtaccgg accgcctcgg cgagcgcctg gtggagcagt
    16861 tcggcggcct cctcgggctt gcccaggcag agcaggacct gggcgagcag ggcgcggacg
    16921 cgggtcccgc gccagggacg gccggatgcc tcgatctcct tcagggcggc gcgcagttcc
    16981 gtctcggcca cggcgtggtc gccgagccgg gcggcgacgt caccggcgaa catgcgggcg
    17041 gcgccgcgct ggtggggcac gccgagccgg cctgcctcgc tctccagagt ggcgcggagc
    17101 gcgtcgaacc gctcgcggtc gggcgcgggg atctccgggg ccccggccag cgccacgtgg
    17161 taggcggcga agacctggca gtgcagcacg gtgaggtact tctcggcggt ggccgagcct
    17221 tcgggggggc cggtggccgg gagcggaccg gggtcggcgc cggtctcgtc gtgggcggcg
    17281 atccgcttct ccaggagctg ttccgcctcc cgctggaagg cgtcgagcgc gtcccagagt
    17341 tccggtcggg cggaccgggc ggcgccggag ttctccccgg cctcctcggc cccctcgccg
    17401 tcggtgatca cgacgtccca ggagagggcg cgggcccggg cgaccagggc gtgccaggcc
    17461 atgcccgccg cctcgtacag ctcggcggcc tcctccatcg cggtccgcgc ggcccggtcg
    17521 cggtcctcgg cgtagagagc gtgggcgcgc tgttcggcga gttcggcgcg gagcctggtc
    17581 caggtgccga ggagggtgtc gtgggcgtac ccctcggcct ccgccagttc ggccaccctg
    17641 tcccacagcg gggtgtcgcc ggggtggccg agggcggcca tccggcgtgc ctcgcggacc
    17701 agttcggtga actccccggg gatctcgcgg gccggggcgg cgaccggggc gggggccgga
    17761 acggcggcgg ggccggtgag cgcggtgcgc aggccgagcg gcagcggctc gtcgaggagc
    17821 gggcgccggt ccagccgcag gcggcgcgcg tcgccgacgg cggtggtgcc gttgcgggtg
    17881 tcgaaggcgg ccgccagccg gccggcctcc tcgcggacct cggccagcag ttcgcccgcc
    17941 gtccggttgc ggccgggcgg accgccgacc ggcgtgtccg cgtggccctc ctcgacgagc
    18001 agggcgagca gcacctcggt gccggtgagg aagccgaggc gggccagcgg ggcgccggtg
    18061 gcctcgaaga gggggcggtt ctcggcgagg atctccacac cgcgcgcgga gttgcgggag
    18121 agcgcgcaga actccaggtg gaggccgacc tcctcctgca tgccggtacg gccgcggacc
    18181 tgccggtagc cggtgaggtg gtgcgagcgt gcctcgtccg tccggcccag gcgcagcagc
    18241 gggagcaggg cgtgcgcctg gctcatctgc ggttcgtcgg agcagctgac ggagtcgtcc
    18301 aggacggggc gccaggtgtc gagggcgccc gcgtcgtccc cggcaaagac ctggtggagc
    18361 gcgtgatggc gggtctcgca cgcctcgcag tcgctgaggc gggtgcgggt cctggtcgcc
    18421 cagaggtcgt aggcgtccgg gacgccggtg ccggtgtgcc gggcgacgtg gtagcgcatg
    18481 gccgccaccg gctggaggcc gtgcccggcg tcctcgtagc gctcacgcat ccggtcgacc
    18541 cagccgtgga cggtggccag cggcatgtcg gggacctgga gcagcgaggt cgtcacccac
    18601 ttgaaccgcc agttgacctg gtggtcctcc cactcgctga aggcaccggg ggtggtctcg
    18661 tgcagcttca gcagccgggc gaagaccacc ggcgacttgc ggtgctcgcc ggtgaactcg
    18721 taggcggcca tcagctccag gagcgccgtg accagcaggg cggggtcgtc gaacgcctcg
    18781 gcggcctcgg ccagttcctc ggcggtcacg gtgcggtgca ggccgtgcgg gcggccgtcg
    18841 ttctcgcgca gcgcgtcgag caccgcctga ggggtgtcca gcatttacgc gtccttccgg
    18901 ggctcggccg ggccggccgg gtgcatggcg tgggtgagca ggccgatgaa ggcccggttg
    18961 agcagggcgc tctcgctcgc ccggagcggg cggcggctga gcagcagggc ctggccgtag
    19021 agggcttcgg cggcggtggt ggcgagtccg cgctcggtga tggtgagggc ctggcgcacc
    19081 agcgggttga ggtggttgag gacgagctgg gcgcggggcg tctcgtcgcg cagcgagccg
    19141 aggatgtcgg cccacaggcc gtcgctctcc gaggcgaggg aggagcgggt ccgctcgtgg
    19201 cgggcctcgc ggttgtcgag gagcagggcg ggcgcggtga ccggctggaa gtcgcggagg
    19261 accacgtcgc agtcgtgggc gccgaccgtc tcgcgggcca gggcgaggaa ggcggcggcg
    19321 cggagttcgg ccgaggggtc gacggcgtcg aggtgggcgg tgacggtggc cgggtcgagg
    19381 tcggtgacgc tgctgccggg acggatctcg gggagccggt ggacgaggtc gcggtcgtag
    19441 gtgtagccgc cgttgacgac gccgagtccg gcggccgagg cgatgggcgc gacctggcgg
    19501 aactcctcga cgctgcgggt gaccaggacg gtcgggtggt tgcgggcgaa ctcctccagg
    19561 gtgacgttgc cgtcggtggt ctcgaagggc agccagggca ggacggtccg caggagttcg
    19621 tcgtcgtagc gggcgagcgc cttgacggcg aggtggtggg tgtcgatgaa gcggtgcagg
    19681 agggccgggt cgctggcggc gaggccggtg agccagtcgc ggatccgctg gccgagggcg
    19741 tcgcggacgg cggccagggt gccgtcctcg tacagcgcct cgcgggaggc ggtggggcgc
    19801 aggctggtgg tgtcgacgac gcagcggacg aagaaggccc agtcggggag gagttcgggg
    19861 gccttgtcgg tgaggagcat ccccttgagg tggacccggt ggccggcgcg ctgggcgggg
    19921 ctgaccgcgg tgggcaggac gtaggcgaca ccacgcagcc cggcggcggg caggtccagt
    19981 tcgatggtgt cgagcggggt gaagtcgaag gtggtgcggc agtacgcggt gagcgcttcc
    20041 cggcgggcga gcggcgagcc gtgcgggcgc tcccacggcg gggtgtcgtt gacccgggtc
    20101 gccgtcccgc gcgggtcgac gacggtgacc tcgtacttca gcaggccgcc gaagtgccgg
    20161 gcgagttcgg tgacccgctc gggggtggtc cactcggcgt tgtcggcgcg cggggtgagg
    20221 cggacggtgg tgcccggctc gggcatcgcg gaggccggga gggtgcggat ggtgtagcgg
    20281 ccgtcggagt ggccgcgcca ctcgacggtg ggcgcgccgg ggtcggcggc gtggcggctg
    20341 acgacggtga tctcgtcggc gacgacgaag caggcgagca ggccgatgcc gaactggccg
    20401 atgaactccc cgcgcgcgga ctccagtccg gcgccgtcca gaccgccgtc ggcgctccgc
    20461 ttggagctgc ggccgatggt ggcgaggaag cggtgcacgt cggcctcggt gaggccgatg
    20521 ccggtgtcgg tgacggtgag cgtctcgccg gtgcgcacgg tgatggcggc gggggcgccg
    20581 gggtcggcgg cctgccgggc ggtcagggcg tcgaccgcgt tctggaggag ttcgcgcagg
    20641 tagacgcggg ggctggagta gaggtggtgg gagagcaggt ccaccagacc acgcaggtcg
    20701 acctggaagc tgtgggagga ctcggagtgg agcacctgtg ggttccctcg tcggggcgcg
    20761 cgccggtccg gcgtcgcgcg gggtcgggtg agccgcccgg cggggccccg gctgtcggcg
    20821 gggcccctcg tcacgggcgg gtggccgggg gccggtgtgc cggggctcag cggccggcgg
    20881 cggcgcggtt ctcgcggtag gcggcggccg ggtcggcgtc gaggtagttc caggggaacg
    20941 cggtgacgat gccgcccgtg ccgtcgaagc agagtttggc caggtcgcgg tcgccggtga
    21001 gcgagaaggc catggcgaag gtgttgtaca cctggagcca gccctgcccg taggcgaagt
    21061 cctcgtgcca gatcgagcgt tcggcggcct cggtgagcga ggcggtgatc tcgggctgcc
    21121 ccaggtactc ggcgtcggcg ccggagtcga gggcgagcca ctgctcgatg tgggcgaggg
    21181 cgacgagctg gccgagcatg ctgccggcgg gggcctcgcg cagggcctgg gaggcgaagg
    21241 cgtgcatctc ctcgtgggag ccgccccact tgtcgcagag ctgctggagc tgctgctggt
    21301 gggcgccgag gtggtgcggg tggcgccgga cggccgcctc gaagcggcgt cgggcgacgg
    21361 tctgcccgac ctggaggccc cggccgctca tctggaggaa gtaccagggg ctgacccact
    21421 ccggctcgcg ctcggcggcc gcgtagagcc acttctcggc ggtccgcagc cggttgtgga
    21481 agacctggaa ctggtcccgc gagacgtgct cggcgcgggc gccggtacgt gcctcccagc
    21541 cccagttgac gtggcgggcc ccggcgacga gcagcggcag ggccgagtcc ggctcggcct
    21601 cgacggcctg gggtatccag ttctccacgt tggcggtcct ggccaccgcg gtgatcagcc
    21661 aggtgcggtc ctcggactcg ggacgctccg tcagctggtc gcgtacggcc gcccagtcgg
    21721 ctgcctcggc cgcctcgcgg atgcgcccga tctcgggctc tccctggtcc tcgtccacct
    21781 cggcggtgga acggccgatc catctcctca gcgaggaccc cgccccccgg agcaacgcca
    21841 tgacaacccc ctgccgcgcc cggtcccctc ggaccgtcgg cgcctcgttc gcaggtgatt
    21901 aagtatcacg cccggacgac acccgcacac tcgtttgacg tgcgggttcg tggccgaggc
    21961 gccctattgg ccccgctccc cgatacggaa ttccgctccc cgggaatgtg acggcgcatc
    22021 cgggattcga ccgcaccggg ccgcatccgg aatgctcgac accgccacgg cgcaccgccg
    22081 ataagcgtgc tccacctgcc ggaaccggcc aaccgcacca cccctgagct gcgcctttcc
    22141 ccatgtggcg gcgcgactgg acgcccgggt caccccagcc gaaagcgcgc acgcatttcc
    22201 tgcacttctc gaccacattc gcggtccgcg tgcaacggaa cgacgccacg caggagcggc
    22261 acgggcacgc gcgcgatacc gcgccggcac ccgcgacacc tccgtcggcg cgtgcggggc
    22321 gacgaggagg ggacagtgtg ccaggcagcc gccgcccgcc ggacgccgtg cccctccact
    22381 ccccccgcga gacgatttcc ccgggcggcg ggccgagcgg cgcccgtacc ctgtggccgt
    22441 gctgatctac gacgaactga cggccgccga gcgtgcgttg tgggacgcct tcctcgaggg
    22501 gcggtgggtg gacctgcggg ccggggtgcc cgaggaggac gaccccgcca cgggggcgca
    22561 gtggggcacc gaacggacgg tcc
//
