LOCUS       NZ_KE951506            20288 bp    DNA     linear   CON 11-DEC-2024
DEFINITION  Actinomyces graevenitzii F0530 Scaffold88, whole genome shotgun
            sequence.
ACCESSION   NZ_KE951506
VERSION     NZ_KE951506.1
KEYWORDS    WGS; HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Actinomyces graevenitzii F0530
  ORGANISM  Actinomyces graevenitzii F0530
            Bacteria; Bacillati; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 107351)
  AUTHORS   Weinstock,G., Sodergren,E., Wylie,T., Fulton,L., Fulton,R.,
            Fronick,C., O'Laughlin,M., Godfrey,J., Miner,T., Herter,B.,
            Appelbaum,E., Cordes,M., Lek,S., Wollam,A., Pepin,K.H.,
            Palsikar,V.B., Mitreva,M. and Wilson,R.K.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-AUG-2013) The Genome Institute, Washington University
            School of Medicine, 4444 Forest Park, St. Louis, MO 63108, USA
COMMENT     ##Genome-Assembly-Data-START##
            Finishing Goal                    :: High-Quality Draft
            Current Finishing Status          :: High-Quality Draft
            Assembly Method                   :: Velvet v. 1.1.06
            Genome Coverage                   :: 191x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000466185.1-RS_2024_12_11
            Annotation Date                   :: 12/11/2024 10:46:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,803
            CDSs (total)                      :: 1,747
            Genes (coding)                    :: 1,701
            CDSs (with protein)               :: 1,701
            Genes (RNA)                       :: 56
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 46
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 5 of 46
            Pseudo Genes (incomplete)         :: 43 of 46
            Pseudo Genes (internal stop)      :: 4 of 46
            Pseudo Genes (multiple problems)  :: 5 of 46
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:20:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 48652
            Orig. end                         :: 68940
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KE951506.1.
            Bacteria provided by Jacques Izard, and Floyd E. Dewhirst, (The
            Forsyth Institute, Department of Microbiology, 245 First St,
            Cambridge, Massachusetts, 02142).  Funded by NIDCR DE016937 'A
            Foundation for the Oral Microbiome and Metagenome'.
            Source DNA provided by Alice Kirega, Anne C. Tanner, Floyd E.
            Dewhirst, and Jacques Izard (The Forsyth Institute, Department of
            Microbiology, 245 First St, Cambridge, Massachusetts, 02142).
            Funded by NIDCR DE016937, 'A Foundation for the Oral Microbiome and
            Metagenome'.
            The bacteria was isolated from a human subject. The phylogenetic
            relative position is available at www.homd.org.
            Coding sequences were predicted using GeneMark and Glimmer3.
            Intergenic regions not spanned by GeneMark and Glimmer3 were
            blasted against NCBI's non-redundant (NR) database and predictions
            generated based on protein alignments. tRNA genes were determined
            using tRNAscan-SE and non-coding RNA genes by RNAmmer and Rfam. The
            final gene set is processed through several programs such as Kegg,
            psortB and Interproscan to determine possible function. Gene
            product names are determined by BER. Gene names are generated at
            the contig level and may not necessarily reflect any known order or
            orientation between contigs.
            This is a reference genome for the Human Microbiome Project. This
            project is co-owned with the Human Microbiome Project DACC.
            This work was funded by the National Human Genome Research
            Institute (NHGRI)/National Institutes of Health (NIH) grant
            5U54HG00496804 for characterization of this genome.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20288
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20288
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20288
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10288](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10288
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(2653..2669)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            2673..3623
                     /locus_tag="HMPREF1978_RS08555"
                     /old_locus_tag="HMPREF1978_00729"
     CDS             2673..3623
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HMPREF1978_RS08555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HMPREF1978_00729"
                     /product="hypothetical protein"
                     /protein_id="WP_021604681.1"
                     /transl_table=11
                     /translation="MDVAVILPGGRGWGPVLKLAEIAAEHLGGRLIKIPAESLPAGRLG
                     KLATLLPPPRPRGEQKLLVIASIGDHLNAVLRSGVRRHYSYVAGWVIDSFWEARIPRVA
                     RSRGWYDHLYVTDQQDLDMWAAAVPCPVGVLPWGADVAGAQVSWADKQVELQRVGRQPQ
                     VWDDDDAVAGAAANAGVSFAGRPPFGDTDEANQAFVETAYRQAKAVLAFGTRTARAKYN
                     HPTKDYVTARWTDSLAYGCLVAGQVPDTPTAREILPSFALVQLSDTDVAQGLEQLKAAL
                     TQYDEEKFTAIRTWAREHLDWRSRLDQIAADAAVN"
     gene            3646..4791
                     /locus_tag="HMPREF1978_RS09080"
                     /old_locus_tag="HMPREF1978_00730"
     CDS             3646..4791
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012744.5"
                     /locus_tag="HMPREF1978_RS09080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00730"
                     /product="glycosyltransferase"
                     /protein_id="WP_051256999.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.2e-28,
                     bitscore: 89.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDKVVLFTSDLGGLGGTTSALNEMARGFNGRGLSVSYMTLGRE
                     VGQLPVPGEVFQVFPGQAYTTDNPLVKRFPGPGGIKLKVLSLYTPVWRKYCLKRLDRHL
                     AKIGPDTAIIALKYNTQKCLTEAIGRGVWAANGAKRPLLVYQNHASMQWMRHFPDYPQV
                     AAPADVFTCLADPYTRETAQILGRQVVTMPNSIRSFELPTAPKTNKIVVLSRLDEAKHL
                     DRLIQAFAQVQGQVKESWQLVIYGEGPSRESLEALVADLHLSDRVSLPGSCYDLTKAFS
                     GASLSALVSGNEGQGLNVVEAAMAGVPSVVTPCSPGAIELAEHGGYLAGGFAVDDIAQA
                     LRQAMCDDEREAVGLRAQTYAQRFSTAAVTDNWLELFARLT"
     gene            4888..6174
                     /gene="eno"
                     /locus_tag="HMPREF1978_RS08565"
                     /old_locus_tag="HMPREF1978_00731"
     CDS             4888..6174
                     /EC_number="4.2.1.11"
                     /GO_component="GO:0000015 - phosphopyruvate hydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004634 - phosphopyruvate hydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="eno"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003784166.1"
                     /locus_tag="HMPREF1978_RS08565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00731"
                     /product="phosphopyruvate hydratase"
                     /protein_id="WP_021604683.1"
                     /transl_table=11
                     /translation="MALIENVHAREILDSRGNPTLEVEILLEDGSFARAAVPSGASTGA
                     FEAVELRDGDKGRYEGKGVEKAVANVNDIIAPEVIGFDAADQRGLDRLMIELDGTPNKG
                     KLGANAILGVSLAAAQASAESAGLELFQYVGGPNAHVLPVPMMNILNGGSHADSNVDIQ
                     EFMIAPIGAPSFREALRWGAEVYHSLKKVVKERGLSTGLGDEGGFAPNLDSNREALELI
                     VEAIEKAGYKPGADVALAMDVASSEFFDSETKTYKFEGEQRDNDYMVKYYEQLIKDFPI
                     VSIEDPLSEDEWEDWKALTAEIGDKVQIVGDDFFVTNPERLAKGIELKAANALLVKVNQ
                     IGSLTETLEAVEMAHRNGYKSMTSHRSGETEDTTIADLAVATNSGQIKTGAPARGERVN
                     KYNQLLRIEESLGEDAVYAGASAFPRFKA"
     gene            6274..6903
                     /locus_tag="HMPREF1978_RS08570"
                     /old_locus_tag="HMPREF1978_00732"
     CDS             6274..6903
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016839.5"
                     /locus_tag="HMPREF1978_RS08570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00732"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_051257000.1"
                     /transl_table=11
                     /translation="MKPRRPTQADPRRRRQRRTSNATGSEAAPRTHPEGLPRVRLQTPR
                     TGEIPQVPQQRDDGRTPVSLRMLLVLVALLVPTFFIAESVHTYFVQHQRYQEVSSQLRA
                     TKQENAQLEAKLQAWRDNNYLKSQARGRLGYVMPGETTYIVVGADSVSETTATSSTPQN
                     SQPWYDRLRQSTREAGKVPKAAKREPSQRGWLDPTTSPTPTVTTTP"
     gene            6915..7424
                     /locus_tag="HMPREF1978_RS08575"
                     /old_locus_tag="HMPREF1978_00733"
     CDS             6915..7424
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005987722.1"
                     /locus_tag="HMPREF1978_RS08575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00733"
                     /product="DUF501 domain-containing protein"
                     /protein_id="WP_005987722.1"
                     /transl_table=11
                     /translation="MSSEVTQADIEALGQQLGRVPRGVVAIAARCVCGRPAVVQTAPRL
                     DDGSPFPTTFYLTLPGAVYGCSALEATHYMDELNQRLAEDEQLAAAYAQAHQAYLAERE
                     KLGHVDEIAGISAGGMPTRVKCLHALVGHSLAAGAGVNPIGDIAIETMRERGLWDKQVC
                     NCKDGK"
     gene            7424..8371
                     /locus_tag="HMPREF1978_RS08580"
                     /old_locus_tag="HMPREF1978_00734"
     CDS             7424..8371
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005987724.1"
                     /locus_tag="HMPREF1978_RS08580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00734"
                     /product="Ppx/GppA phosphatase family protein"
                     /protein_id="WP_005987724.1"
                     /transl_table=11
                     /translation="MRLAAIDCGTNTIRLLIGDYELTDQGIIINELERSGEIVRLGVGV
                     DRTGRLNEEAIERTLDFTRACAERFEHYGVQQARFVATSASRDAANRDVFVNGVWAILG
                     FEPEVISGEEEAALAFLGSKVGSNVDMTHPRLVVDLGGGSTEFSLGTQYPDAYISTNMG
                     SGRVTERFLSEGVTPASEAAAREFVRSMLDTAAEQVDFSAAHSLVGLAGTITAVTAHAL
                     GLEYFDSQKIGGAQVPVEDMRRSCDAIIHATPEQLEQWEFIAPGRRSVIAAGALICDEM
                     VARVAADTANTDHPVRHINVSLHDILDGIALSQL"
     gene            8368..9129
                     /locus_tag="HMPREF1978_RS08585"
                     /old_locus_tag="HMPREF1978_00735"
     CDS             8368..9129
                     /EC_number="4.2.1.10"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013640.5"
                     /locus_tag="HMPREF1978_RS08585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00735"
                     /product="type I 3-dehydroquinate dehydratase"
                     /protein_id="WP_021604685.1"
                     /transl_table=11
                     /translation="MNQSFAALLLAARRERQLVIATALTDGAPSGQARQARLAQQQGAG
                     ALELRADLLADPAQVRAALTAVRAASSLPLLLTYRSATEGGKGAGHGQGYEDYLASLLQ
                     LRPAVAAVDIEMACPASKALVAEAKAGGYDVVGSCHDFTATPSAAQITQKLAQITAAGA
                     DITKVAYMPRTAQDVAALRHAAHDFAGAYPHQPLIAISMGQLGAPSRTDLVNCLTFATI
                     ADGAASAPGQATIAYVRAWLENTPGTSTIEL"
     gene            9126..10004
                     /locus_tag="HMPREF1978_RS08590"
                     /old_locus_tag="HMPREF1978_00736"
     CDS             9126..10004
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.5"
                     /locus_tag="HMPREF1978_RS08590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00736"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_021604686.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.7e-14, bitscore:
                     46.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQPLDSSSRAAGIPIGIRAHLAHAALQVLAQDAGVDILHIKGPA
                     VHPSIGRALTHSTDADVLVRPEQVKLYVKALLDHGWRHNTSFETGSAFEHAATFFHPTW
                     GYVDLHRRYPGITAPKAFNNLWARRIHQMLGGVRCATPALIDQRLILLLHVARNSSGTS
                     DPDYALVWATLDECAQADLRRRARELGAQVGLAAALGELDQYRQDPTHDLWMMFSTGEG
                     GRLDEWKARFKAANGPLAKARIVGRALLVNTDHLTMRLGHEPTPAEVRQEYVERYRAAL
                     REGMDKVKRKL"
     gene            10001..10288
                     /locus_tag="HMPREF1978_RS08595"
                     /old_locus_tag="HMPREF1978_00737"
     CDS             10001..10288
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="HMPREF1978_RS08595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00737"
                     /product="PqqD family protein"
                     /protein_id="WP_021604687.1"
                     /sec_met_domain="PqqD_RRE (E-value: 2.3e-09, bitscore:
                     29.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-10, bitscore: 33.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.5e-08,
                     bitscore: 25.8, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYLHPSRLGYYDDPTEQAIYLAPLPDGEISRLEGPARAIWIGAD
                     GAENVAEVAQRVAPYFNVTADQIEADVSEFVSQLIAGALLEEVMDLKDAR"
     aSDomain        10034..10258
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HMPREF1978_RS08595_PqqD_RRE.1"
                     /evalue="8.20E-10"
                     /identifier="RREFam006.1"
                     /label="HMPREF1978_RS08595"
                     /locus_tag="HMPREF1978_RS08595"
                     /protein_end="86"
                     /protein_start="11"
                     /score="29.3"
                     /tool="antismash"
                     /translation="YDDPTEQAIYLAPLPDGEISRLEGPARAIWIGADGAENVAEVAQR
                     VAPYFNVTADQIEADVSEFVSQLIAGALLE"
     gene            10285..10854
                     /locus_tag="HMPREF1978_RS08600"
                     /old_locus_tag="HMPREF1978_00738"
     CDS             10285..10854
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013607.5"
                     /locus_tag="HMPREF1978_RS08600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00738"
                     /product="low molecular weight phosphatase family protein"
                     /protein_id="WP_021604688.1"
                     /transl_table=11
                     /translation="MSGSYGASPRLLFVCTANICRSAYAEVRARQMLGLDAGWAFFSAG
                     VPGTVGREMDPPMVAQAVARGVALEDCLAMRSRQMREGILRRSRLVVTMANSHRVALLD
                     DFPAYAERYWTLGQLADAATLLQRDDAWLSYDTDQLVQALHAVRGPAGGGRDVADPYRR
                     GDAAMAAAADTIDAYLRTILPLLSRG"
     gene            10976..12892
                     /locus_tag="HMPREF1978_RS08605"
                     /old_locus_tag="HMPREF1978_00739"
     CDS             10976..12892
                     /GO_process="GO:0000271 - polysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF022077.5"
                     /locus_tag="HMPREF1978_RS08605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00739"
                     /product="polysaccharide biosynthesis tyrosine autokinase"
                     /protein_id="WP_021604689.1"
                     /transl_table=11
                     /translation="MTRVNLGFLILCVLLGLAGGFGYASAQPWTYTATSQAMVVVPGTD
                     AFSQNSISGQKASVYAVLAGSQNVANRVAKTLKTSNMEGTLSGSADAVPGLFTLTATAS
                     TPERARDIANAGIKAVSDEANAITTLNAPTVQPTTKTTTNPDGTQVTTTTQSVDGTTNV
                     TTTDNSYRETRVTQTLQAVAPSAPSSPDFYKLSGMGALAGLVIGYLVVFMRRLMDNRVR
                     HNSDVEELLGSSVLAVVPKSTELNAKGRQNVDGLGQAAEALRHLRTNLRFVDVDNPPRA
                     IVMTSANPGEGKSTMSAVLAQMLASSGQRTVLIDTDLRKPVVHKIFGLDGSVGLTQILA
                     GDMQLSDVAQKIEGQPNLRVVPAGRIPPNPSELLGSQRMKALMDYLKDDAMVIMDAPPL
                     LPVTDAGLLSALADGAILVMEVGGTYKEQARLCGKIFKQVDGRLLGVVLNRASRRNLGS
                     VYYGYGYGGYGQNYYYYEEDEKRKLLGFIPLPGHRKRKRENQIVSIQEEEVHPLPKDKQ
                     SRRSSRRAARSEAPAQVPAQLPAATITSSPVSSRTSAASPRVSTVVNPEPVSVPSVQDS
                     GDDTATTEAVASPVGTGMPVPPPAASISQPVGEETAVQTSAAFGAPQASVPTRRSLRER
                     RNG"
     gene            complement(13006..13413)
                     /locus_tag="HMPREF1978_RS08610"
                     /old_locus_tag="HMPREF1978_00740"
     CDS             complement(13006..13413)
                     /EC_number="5.2.1.8"
                     /GO_function="GO:0003755 - peptidyl-prolyl cis-trans
                     isomerase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017178883.1"
                     /locus_tag="HMPREF1978_RS08610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00740"
                     /product="FKBP-type peptidyl-prolyl cis-trans isomerase"
                     /protein_id="WP_021604690.1"
                     /transl_table=11
                     /translation="MIATPLPTVSGSKGSKPTLTFPDAEAPTDLEIQVLDAGDGQIVEP
                     GDTIVCNYLGQIWGGQVFDNSFDRGQPLSFQIGVGMVIRGWDEGLVGQRVGSRVLLSIP
                     SELGYGSRGVPQAGIKGGDTLVFVTEILAVL"
     gene            13536..14759
                     /locus_tag="HMPREF1978_RS10170"
                     /old_locus_tag="HMPREF1978_00742"
     CDS             13536..14759
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013884.5"
                     /locus_tag="HMPREF1978_RS10170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00742"
                     /product="acyltransferase"
                     /protein_id="WP_155881632.1"
                     /transl_table=11
                     /translation="MASNTGIVNLPRLTSLRFFAASGVFMYHLCRIYPGMPLKATSTVG
                     YVGVAFFFVLSGFVLTWSTPIYNGVEAKQFWIKRVARVYPSHLVMMVIALLLPATPLPL
                     TWVAVPPNALLLQSWFSPNDIAFGVNAVSWSLSCEAFFYLCAPLLISVLNALKPLQRYL
                     AAAAGAGVAWSIGLVLAANGSNVYAYHLPIVRIGEFIIGIALALALRDGVRLPFRSVCL
                     AGVTTAVMVMVCLRTGQLTTVSGILMVPAFAWLIYACAQADLDGVRGVLRLKLLEHMGI
                     TSFAFYLVHELVLLNLKPLPWPHGSKLVNLATVIVLWIICQAAAELLYRGVERPAQRRI
                     RAWAAAHKGKNETKAGHYSLQPGRASGQAGTPGTGVDDAGNGTSVTGGHRLDSAGSAAG
                     AGHDGTVA"
     misc_feature    15251..15266
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    15519..15535
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.06"
                     /tool="antismash"
     gene            15619..16401
                     /locus_tag="HMPREF1978_RS10175"
     CDS             15619..16401
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HMPREF1978_RS10175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_231196732.1"
                     /transl_table=11
                     /translation="MEIVSREEVTPLVLRKELEVRDVRFRYDDDAPEVLKGVDLRIPFG
                     TKAAFVGSSGAGKSTLLDLLMGLQVPTSGEILIDGADMRENIYGWQSNIGVVPQNVFIT
                     DRTIAENIAFDQRREDIDPERVREALEGARLWEFVSSQPEGIWSEFGEQGRRLSGGQLQ
                     RVGIARALYRRPNLLILDEATSALDNETEAEIAETIDNLSGKITVIIVAHRLSTIRNAD
                     QIVFLANGVVDGIGSFIELQERSEGFRNLVKLAALEQA"
     gene            complement(16507..17448)
                     /locus_tag="HMPREF1978_RS08625"
                     /old_locus_tag="HMPREF1978_00744"
     CDS             complement(16507..17448)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025082.5"
                     /locus_tag="HMPREF1978_RS08625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00744"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_021604694.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1e-10, bitscore:
                     34.1, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLRQDLGQASWVCKDFIKHRSLPAQMRAMKHMQLPNLPRRRRKE
                     GEVWGVTLVKNEADILPLVIEHLFAQGISHIIVGDNMSTDDTPEILEEFALKTGRVHVA
                     RDREPAHIQAEKMTYMCHAAWRAGADWIIPFDGDEFWFAPEGGLADYLRAQSADMIYAD
                     FLHMVPTTPGPEDLINAEFIVDTKPSFPGKVAVRSHRWLKMGPGNHYALRVGATSHGLK
                     IAHAQYRSPEQVARKVRQGSAATALTGEDLSWFSPHWEAGSKLSNAEILEVWENISHGR
                     PDERIQFAANGPMLKAHPLRWKTWNESGELNS"
     misc_feature    17497..17514
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            17558..18520
                     /locus_tag="HMPREF1978_RS09085"
                     /old_locus_tag="HMPREF1978_00745"
     CDS             17558..18520
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025082.5"
                     /locus_tag="HMPREF1978_RS09085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00745"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_005987740.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.2e-10,
                     bitscore: 33.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDYGRFVYKSRVWAGYANRAIKRSFSTQQVNKRREILSSRQVPD
                     FPVTPGAVMAVTMVKDEADIIGRVITHLLEQEVDRVIVADNMSSDDTPQILAELASEYP
                     VTVVQDNLAAYYQSEKMTALAKLARNHGAKWVIPFDADELWFAPGATLASYLRASDKKQ
                     FRAAVHNAIPTETAGVWRLDQRAASLPKTAVATLPGMNISMGNHFVDRPGETDAGMRLI
                     HLPWRSLEQIERKSTQGSLALRLAEHEGRLGRQWHETETALAQDAAGLWQDLLNGNPHP
                     ALDLNWSADSELITLDELPAWPFARPYDITGPNRIEEVK"
     gene            complement(18743..19720)
                     /locus_tag="HMPREF1978_RS08635"
                     /old_locus_tag="HMPREF1978_00746"
     CDS             complement(18743..19720)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005987741.1"
                     /locus_tag="HMPREF1978_RS08635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HMPREF1978_00746"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_034479571.1"
                     /transl_table=11
                     /translation="MSNPVFSSNPVFKQGAQQTTPAGYPTMPGYTPGHPNQGGYGAPYG
                     QNAYGQNTYDQNAYGQTGYADPYGQAQLEQQYAAPAASAVETGRMTYDDVIVRTAALLL
                     TVVITAAFGWYLVANAYQAQSAQAMGTAVMVTSTGAVGALIFGLINTFKREPSPVLMFI
                     YAVAEGLMLGGFSAAVEITRYSGIVLQAVLGTLATFVVMLCLYKFANFRLQGKFLKIFM
                     IALIGYGAFAMVNFLLQLTGLVGGEFGLYSMTVAGIPLGLIIGPIAVIMAAVSLVLDFQ
                     NTESLVNAGAPRRYAWTCAFGLVVTLVWLYIEILRLLAIFSSDD"
     misc_feature    20026..20037
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.01"
                     /tool="antismash"
ORIGIN
        1 cctgggatgg tggtcgttta acgcctttgc ttccaccccg gatatgccta gtttgcctat
       61 tactgaggtg cccggctatg gcggtggctt tgaggcggct gccaggcagg tggggcagca
      121 ggctaaggct ggctggcggg tagttattag cgctgatggt ccgggcccgg cgcgccgttt
      181 ggctgaggtt ttgggtgagg gagatattcc tgcccgcatt gtggctgatt tggatgaggc
      241 tgcggatctg ggcgctagcg atggtagcgg cgacggcgtg gtgcggattt tgcctgcctc
      301 ggcttatcag tctttcctga ttccttccca aaaatttgct tttattggcc agtcgcagat
      361 cacggggcga gctagtgctt ctccgcgcgc ccctaaggcg gtgccggcgc ggcgttcaaa
      421 gcgtagcgtt gaccccctat cgctgcatcc gggtgatttg gtggtgcact cgcaccatgg
      481 ggtgggtcgt tttgtggagc tcacgcgccg gcctgtgccc ggaaaccgta attctagccg
      541 cgaatatttg gtgattgagt atgcgccttc taagcgtggt cagcctgctg accggctcat
      601 ggtgcctact gactcgcttg atgcggttag taaatatgtg ggtggtgatg ccccggcgct
      661 gagcaagatg ggtggcgccg actggcaaaa aactaaggct aaagctcgca aggcggtgcg
      721 tgaaatcgcc ggggagctgg tgcgcctgta tgcggcccgc caggccgcta agggccacgc
      781 ttttagccct gacacccctt ggcaggcgga gctagagcag tcttttgcct acactgaaac
      841 ccctgatcag ctggtcacca ttgatgaggt taaggctgat atggaaaaga gcgcccctat
      901 ggatcgtctg atctgtgggg atgtgggtta cggcaaaact gagattgcgg tgcgggcagc
      961 ttttaaagct gtccaggacg gcaagcaggt ggcggtgctg gtgcccacca cgctgctggt
     1021 gtctcagcac gcagaaactt tcacggagcg ttttgctggt ttcccggtga ccgtggcgca
     1081 gctgtcgcgt ttccaaagcg ctaaagaaag ccagcaggtg ctgcgtgacc ttgagcaggg
     1141 gcgtatcgac gtcgtcgtag gcacccaccg cttactgacc ggcgcagtta aatttaagga
     1201 cctggggctg gtaattatcg atgaggagca gcgctttggg gtggagcata aagaagccct
     1261 caaagctatg cgcacggatg tggatgtgct gtccatgtcc gccaccccca tcccgcgcac
     1321 gctggaaatg gcggttagcg ggctgcggga aatgtccacc ctggccaccc cgccggagga
     1381 tcgccacccg attttgacct atgtaggccc ctatgagact aagcaggtgg gcgccgccat
     1441 caggcgtgag ctgctgcgtg aggggcaggt gttctatgtg cacaacaagg ttgaagacat
     1501 tgatgcggtg gctgcgcgtc taactgaact ggtacctgaa gctaatatcg ccaccgccca
     1561 cgggcagatg agtgagcacc gcctagagaa ggtaattgac gccttctgga agcgtgaaat
     1621 tgatgtgctg gtgtgcacca ccattgtgga aaccggcctg gatgtgtcta acgccaacac
     1681 gttgattgtg gaccgcgccg accgtatggg gctaagccag ctgcatcagc tgcgtggccg
     1741 ggtggggcgt gggcgtgagc gggcctacgc ctacttccta tacccgggcg acaagcccct
     1801 tactgaaacc gcccaccagc gtctgcgcac cattgctaac aacactgatt tgggtgcggg
     1861 tatgcaggta gccatgaagg acctagaaat tcgcggcgct ggtaatctgc tgggcgggga
     1921 gcagtccggg catatcgccg gggttggctt tgacctgtat ctgcgcatgg tgggtgatgc
     1981 ggtggaagcc tacaagcgcg gcgtgggcct gggtgaagat gaggaggcag ctgagcctga
     2041 cttgaaggtg gagctgccca ttgacgccaa tattcccgag gagtacctgc cccatgagcg
     2101 cttgcgtttg gaggcttacg caaagatggc tgcagctaag tctgatagcg acgtcgacga
     2161 cgtcctagcg gagctagctg accgttacgg cccggtgcct gagcccaccc agaacttggc
     2221 acagctggcc cgtctgcgcg tatatgcagc cagcttgggg gtgtacgaga ttgtggcgca
     2281 gggtaaatct atccgttttg cgccggtggc cctgcctgag tctggggcga tgcgcgtcaa
     2341 gcgcctctat ccgggcacaa tcattaagcc agccacccgt accctggtgg tgcccgcccc
     2401 gggcacgcgc ggtttgcgcc gtgaaacttt aagtgccagt gagctgctgc gctgggcgca
     2461 ggtgttcttg cacgcggttg tggccggcga ggctgaatac gaaaccgaag ccaccaaata
     2521 ccgcagccgc taagtgcgcc ggcgcccatc gcgcgccaaa cgcgccggcg ccttgcccgc
     2581 atccgcgcag ctgacccgcc cgcgcggcgc ggatccaaaa cggccacgct cttgcgtgta
     2641 cacccaggaa gtttgcaggt aaattacagg ttatggatgt tgcggtaatt ctgcctggcg
     2701 gacgtggctg gggcccggtt ttaaaactcg ctgagatcgc tgccgagcac cttggcggcc
     2761 gcctaatcaa aatcccagcc gaatccctgc ccgctgggcg gttaggcaaa ctagccaccc
     2821 tgctgccgcc gccacgccca cgtggagaac aaaaactgct ggttatcgcc tctattggtg
     2881 atcacctcaa cgcggtttta cgctccgggg tgcgccgcca ctacagctat gtggccggct
     2941 gggtgatcga cagcttctgg gaggcgcgca tcccccgcgt ggcccgctca cgtggctggt
     3001 acgaccacct ctacgtcact gaccagcagg atctagacat gtgggcagcg gcagtgccct
     3061 gcccggtcgg ggtactgccc tggggtgccg acgtcgccgg agcccaggtg agctgggctg
     3121 ataagcaggt ggaattgcag cgtgtaggcc gtcagcccca ggtgtgggat gacgacgacg
     3181 ccgtagctgg cgccgccgcc aacgcggggg ttagctttgc tggccgcccc ccatttggtg
     3241 acaccgatga agccaaccag gcttttgtgg aaaccgccta ccgccaagcc aaagcggtac
     3301 tagctttcgg cacccgcacc gcccgcgcca aatacaacca ccccaccaag gattacgtaa
     3361 ctgcgcgctg gactgactca ctggcctacg gctgcctagt agccggccag gttcccgata
     3421 cccccaccgc ccgcgaaatc ctgccatctt tcgcattagt gcagctcagc gatactgatg
     3481 tggcgcaggg cctagagcag ctcaaagccg ccctaaccca gtatgacgaa gaaaagttca
     3541 ccgctatccg cacctgggcg cgtgaacatc tagattggcg ctcgcggcta gatcagatcg
     3601 ccgccgacgc agccgttaac tagagcagtg ctcctggagt taaccatgag ccttgataaa
     3661 gtcgttttat ttacctctga cctgggcggt ctagggggta ctacctctgc actaaacgaa
     3721 atggcacgtg gctttaacgg gcgcggcctt tcggttagct atatgacctt agggcgtgag
     3781 gtgggccagc tacccgtgcc cggcgaggtg tttcaggtgt tcccgggcca ggcttacacc
     3841 accgacaacc ctctggtgaa gcgttttccg gggccaggtg gcataaaact aaaagtcctg
     3901 agcctataca cgccggtgtg gcgtaaatac tgtttaaagc gtttagatcg ccacctggct
     3961 aaaatcggcc cggataccgc cataatcgcg ttaaagtaca acacccaaaa atgcttaact
     4021 gaggctattg gtcggggtgt gtgggcagcc aatggcgcca agcggccgct gctggtttat
     4081 caaaaccatg cctcaatgca gtggatgcgt cattttcccg actatccgca ggtggccgcg
     4141 ccggcagatg tgttcacctg tttagctgat ccttatacgc gtgaaaccgc ccagatcctg
     4201 gggcgccagg tggtgacaat gcctaactcg attaggtctt ttgaactgcc tacggcgcca
     4261 aaaaccaata aaatcgtggt tttgtccagg ctggatgagg ctaaacacct agatcggtta
     4321 attcaggctt ttgcgcaggt acaggggcag gtaaaggaaa gctggcagct ggttatttac
     4381 ggtgaaggtc catcgcgcga aagtctcgaa gctctggttg ctgatctgca ccttagtgac
     4441 cgcgttagcc tacctggcag ttgctatgac ttaactaaag cttttagtgg cgctagccta
     4501 tccgctttag tttctggcaa tgaaggtcag gggttgaatg tggttgaggc ggccatggct
     4561 ggggtgccct cagtagttac cccctgctca cctggcgcga ttgagttggc tgagcacggt
     4621 ggttacttgg ctggcggctt tgcggtggac gacattgcgc aagctttgcg tcaagctatg
     4681 tgcgacgacg aacgtgaggc ggtggggctg cgggcgcaga cctatgcgca gcgttttagt
     4741 accgctgcgg taaccgataa ctggcttgaa ctattcgcga ggttaaccta aaggtcattt
     4801 tgcagggcta ataccctcgc gcaggtagct taggcaagct agacttggtc acgtaatatt
     4861 cctgtttcga ttacttagga gcaccacgtg gccctcatcg agaacgtaca tgcacgcgag
     4921 attctagact cccgcggcaa ccccactcta gaggttgaaa tcctacttga ggatggttcc
     4981 ttcgcccgcg cggctgtccc ctccggcgct tccactggtg cttttgaggc tgtggaactg
     5041 cgcgacggcg acaagggccg ttacgagggt aagggtgtag agaaggccgt tgctaacgta
     5101 aacgacatca tcgcccccga ggttatcggc ttcgacgccg ctgaccagcg cggcctagac
     5161 cgtctaatga ttgagctaga cggcaccccc aacaagggca agctgggcgc caacgctatc
     5221 ttgggtgtgt ccctggctgc cgctcaggcc tccgccgaat ctgccggtct agagctattc
     5281 cagtacgttg gtggccccaa cgctcacgtc ctacccgtcc ccatgatgaa catcctcaac
     5341 ggtggctctc acgctgactc caacgttgac atccaggagt tcatgattgc ccccatcggc
     5401 gctccctcct tccgtgaggc tctgcgctgg ggcgccgagg tctaccactc cctgaagaag
     5461 gtcgtcaagg agcgtggcct gtccaccggt ctaggcgacg agggtggttt cgcccccaac
     5521 ctagactcca accgtgaggc tctagagctg atcgttgagg ccatcgagaa ggctggctac
     5581 aagcccggcg ccgacgttgc cctggctatg gacgttgcct cctccgagtt cttcgacagc
     5641 gagaccaaga cctacaagtt cgagggcgag cagcgcgaca acgactacat ggtcaagtac
     5701 tacgagcagc tcatcaagga cttcccgatc gtctctatcg aggacccgct aagcgaagac
     5761 gagtgggaag actggaaggc cctgaccgcc gagatcggtg acaaggtaca gatcgttggt
     5821 gacgacttct tcgtaaccaa ccccgagcgt ctagccaagg gcatcgagct caaggctgcc
     5881 aacgccctgc tggttaaggt aaaccagatc ggttctctaa ccgagaccct ggaggccgtg
     5941 gagatggccc accgcaacgg ttacaagagc atgacctctc accgttccgg cgagaccgag
     6001 gacaccacca tcgccgacct ggctgttgcc accaactccg gccagatcaa gaccggtgct
     6061 cccgcccgtg gcgagcgtgt caacaagtac aaccagctgc tgcgtatcga ggagtccctg
     6121 ggtgaggacg ccgtatacgc cggcgctagc gccttcccgc gcttcaaggc ctgataaagc
     6181 aggtcctgag ctgaaccagc tctgactaaa cgggcggggt gcatttaagc gccccgcccg
     6241 ctttgtatct agccctcagg tagtatcaaa ggtgtgaagc cccgtcgccc tacccaagct
     6301 gacccacgtc gtcgtcgcca gaggcgaacg tcaaacgcta ccggcagcga ggcagcccca
     6361 cgcacccacc ctgaaggcct gcccagggtc cgtttacaaa cgccccgcac tggcgaaatc
     6421 ccgcaggtac cccagcagcg cgacgacggg cgcaccccgg tttcgctgcg gatgctatta
     6481 gtgctagtgg ccctgctagt gcctacattc tttattgctg aaagcgtgca cacctacttt
     6541 gtgcagcatc agcgctatca ggaagttagc tcccaactgc gcgctaccaa gcaagaaaac
     6601 gcccagctgg aggccaaact gcaggcctgg cgagacaaca actatctaaa aagccaggca
     6661 cgtgggcgcc ttggctacgt aatgccgggg gagaccacct acattgtggt gggcgctgat
     6721 tcagttagcg aaactaccgc caccagctcc accccccaaa atagccagcc ctggtatgac
     6781 cgcctgcgcc agagcactcg tgaagccggt aaagtcccca aggctgcgaa acgtgaaccc
     6841 tcccagcgcg gctggctaga tccaaccact agccccacgc ctaccgtaac caccacccca
     6901 taaagcgaga gcacatgagt tcagaagtta cccaggccga tattgaagcc ctaggccaac
     6961 agctggggcg cgtgccgcgc ggggtagtag ccattgccgc gcgctgcgtg tgtggtcgcc
     7021 cggcggtggt gcaaaccgct ccgcgtctag acgatggctc acccttcccc accaccttct
     7081 acctgaccct gccaggggcg gtatatggct gctcagccct ggaagccacc cactacatgg
     7141 atgagctaaa ccagcgtcta gctgaagatg agcaactggc cgccgcctac gcccaggccc
     7201 accaggccta cctggcagag cgtgaaaagc ttggccacgt ggacgaaatt gccggtattt
     7261 ccgcaggtgg tatgcccacc cgcgttaaat gcctacacgc cctagtgggc cactcactag
     7321 ccgccggtgc gggggtaaac cccatcggcg acattgccat tgaaaccatg cgtgaacgcg
     7381 gcctgtggga taagcaggtt tgcaactgta aggacggtaa ataatgcgcc tggctgctat
     7441 tgactgcggt accaacacta tccgtttgct gatcggcgac tatgagctta ccgatcaggg
     7501 cattatcatc aacgagctgg agcgctcagg tgagattgtg cgcctaggtg tgggggtaga
     7561 ccgcactggg cgcctaaatg aggaagctat tgagcgcacc ttggacttca cccgtgcctg
     7621 cgctgagcgt tttgagcatt acggggtgca acaggcccgg tttgtggcca cctccgcctc
     7681 gcgtgacgcc gccaaccgtg acgttttcgt caacggcgtt tgggcaattt tgggttttga
     7741 acctgaagta atcagcggtg aagaagaagc tgccctggcc ttcctaggtt ctaaggtggg
     7801 cagcaatgtg gatatgaccc acccgcgcct ggtagtggat ttgggtggcg gttccaccga
     7861 gttcagcctg ggcacccaat accctgacgc ctatatctct accaacatgg gttcggggcg
     7921 cgtcaccgag cgtttcctaa gtgaaggcgt cacccctgcc tctgaagcag ccgcccgtga
     7981 gtttgtgcgt tccatgctgg atacggctgc cgagcaggta gatttcagtg ctgcccactc
     8041 cctggtggga ctggctggca ctatcactgc ggttaccgcc cacgccctgg gactggaata
     8101 tttcgacagc caaaaaatcg gtggggcaca ggtgcccgta gaggacatgc gccgctcctg
     8161 cgacgccatc atccatgcca ctcctgagca gttagagcag tgggaattca ttgcccccgg
     8221 acgccgcagc gtaattgccg ccggcgcctt gatctgcgat gaaatggtgg cccgcgtggc
     8281 ggctgacacc gctaacaccg atcacccagt gcgccacatt aacgtgtctc tgcacgatat
     8341 tctcgacggt atcgccctct cgcagctatg aaccagtcct ttgctgccct gctgctggcg
     8401 gcgcgcagag agcgtcaact ggtgattgct acggcgctaa ctgacggcgc tcctagcggc
     8461 caggcccgcc aggctcgtct ggcccagcag cagggggcag gggctttgga actgcgcgcg
     8521 gacctgctag ctgatcccgc ccaggtgcgc gcagcgctga cggcagtgag ggcagcctcc
     8581 agcctgccgc tgctactgac ctaccgctca gctactgagg gtggtaaagg cgctggtcac
     8641 ggccagggct atgaggatta tttggctagt ttgctacagt tgcgcccggc cgtggccgca
     8701 gtagacatag agatggcttg ccctgccagt aaggcgctgg tagctgaggc taaagcgggt
     8761 ggctacgacg tcgtcggctc ctgccacgac tttacggcca cccccagcgc ggcccagata
     8821 acccaaaaac tggcgcaaat tactgccgcc ggcgcggata tcaccaaagt ggcttacatg
     8881 ccacgcactg cccaggacgt ggccgcgctg cgacatgccg cccacgactt tgccggcgcc
     8941 tacccccacc agccgctaat tgctatttca atgggccagc tgggcgcccc aagccgcact
     9001 gacctggtca attgtctgac ctttgcgaca atcgccgacg gcgctgctag tgccccagga
     9061 caagcaacta ttgcctacgt gagagcctgg ctagaaaaca ccccggggac aagtactata
     9121 gaactatgag ccagcccctc gactcctcct ctcgggccgc tggaatcccc atcggaattc
     9181 gcgcgcattt agcccacgcc gccttgcagg tcctagcgca agacgcaggc gtggatattt
     9241 tgcatatcaa aggcccggca gttcacccca gtattggccg cgccctaacc cacagcaccg
     9301 atgccgatgt gctggtgcgc ccagagcaag taaagctata cgtcaaagcc ctgctagatc
     9361 acggctggcg tcacaacacc tcatttgaaa ctggctccgc tttcgagcac gcggccacct
     9421 tctttcaccc cacctgggga tatgtagatc tgcaccggcg ctacccgggg attaccgccc
     9481 ctaaagcttt taacaacctc tgggcgcggc gcatccacca aatgcttggt ggagttcgct
     9541 gcgctacccc agcactaatc gaccagcgcc taattttgct gctacacgta gcgcgtaact
     9601 cctcggggac atcagacccc gactatgccc tagtatgggc aaccctagac gagtgcgccc
     9661 aagcggacct gcgccgtcga gcccgggaac taggggccca agtggggcta gccgccgcgc
     9721 taggagaact agaccaatac cgccaagacc ccacccacga cctgtggatg atgttctcca
     9781 ccggtgaggg cgggcgccta gacgagtgga aagcccgctt taaagcagcc aacggcccgc
     9841 tggctaaagc ccgcattgtg ggccgggcgc tgctagtaaa caccgaccac ctaaccatgc
     9901 ggctaggtca cgaacccacc ccggctgaag tgcgccaaga atatgtggag cgctaccggg
     9961 cggctttgcg tgaaggaatg gacaaagtta agaggaaact gtgacctacc tgcacccctc
    10021 acgcctgggt tactacgacg accccactga gcaggccatt tacttggcac cactacccga
    10081 cggcgaaatc tctaggctag aaggccctgc ccgcgctatt tggatcggcg ctgatggggc
    10141 tgagaatgtg gctgaagtag cccagcgggt tgccccctat ttcaacgtta cggctgacca
    10201 aattgaggca gacgtaagcg aatttgttag tcaactaatt gctggcgcac ttctggagga
    10261 agtcatggac ctgaaggatg cccgatgagc ggcagttacg gggcctcgcc ccggttgctg
    10321 tttgtgtgca ccgccaacat ttgccgtagc gcctatgctg aggtgcgcgc ccgccaaatg
    10381 ctgggcctgg atgccggctg ggcctttttt agtgccggcg tgcctggcac agttggccgc
    10441 gaaatggacc cgcccatggt ggctcaggcg gtggcacgtg gcgtggccct ggaagactgc
    10501 ttggctatgc gttcgcgcca aatgcgtgaa gggattttgc gtcgctcacg cctagtggtg
    10561 accatggcta actcgcaccg tgtggctttg cttgatgatt ttcctgccta cgctgagcgt
    10621 tactggactt tggggcagct agccgacgcc gccaccttgc tccagcgtga tgacgcctgg
    10681 ctgagctatg acactgacca gctagtgcag gcgctacacg cagtgcgtgg gccagctggg
    10741 ggtggacgcg acgtagctga cccatatcgg cgtggagatg cagctatggc tgcggcggcc
    10801 gataccattg atgcgtactt gcgcactatt ctgccgctac tatcgcgcgg ctaaaggcct
    10861 agttgatacc gtactaacat atagattttt caggttcccc acctgatccc tggcatcgcc
    10921 aggccgctcg gaagaagggc aataacccac tgtgacaatc caagactttg ttaggatgac
    10981 ccgggtcaac ctgggtttct taatcctatg cgtgctattg ggtctagccg gtggtttcgg
    11041 ctatgccagc gcccagccat ggacctacac cgctacttcc caggcgatgg tggtagttcc
    11101 cggtaccgat gcttttagcc agaactctat ttctggtcag aaagctagcg tgtatgcagt
    11161 cctggctggt tcgcagaacg tggctaaccg cgtggctaag acccttaaga cctccaacat
    11221 ggagggaact cttagtggta gtgctgacgc cgttcctggt ctgtttactc tgaccgctac
    11281 tgcttccacc ccggagcgcg ctcgtgacat cgctaatgcc ggcatcaagg ctgtgtctga
    11341 tgaggctaac gcgattacca ctcttaacgc gcctaccgtg cagcccacca ccaagaccac
    11401 cactaaccct gatggtaccc aggtaaccac caccacccag agcgtggatg gcaccaccaa
    11461 cgtaaccact acggacaaca gctaccgcga aacccgcgta acccagaccc tgcaggcagt
    11521 tgctcccagc gcccctagct cccctgactt ctacaagctc agcggcatgg gtgccctggc
    11581 tggtctggtg attggctacc tggtggtatt catgcgccgc ctgatggaca accgtgtacg
    11641 ccacaactcc gatgttgagg agctgctggg ttcttccgta ctggcggttg tacctaagtc
    11701 caccgaactg aacgccaagg gccgtcagaa cgtagacggt ctgggtcagg ccgctgaggc
    11761 cctgcgtcac ctacgtacca acctgcgctt cgtggatgtt gacaacccgc cgcgcgcaat
    11821 cgttatgacc agtgctaacc ctggtgaagg taagtccacc atgtctgccg tgttggcaca
    11881 gatgctggct tcttccggtc agcgcaccgt gctaatcgac accgacttgc gtaagcccgt
    11941 ggtgcacaag atcttcggcc tagatggttc tgtgggtcta acccagatcc tggctggtga
    12001 catgcagctg tccgacgtcg ctcagaagat tgagggtcag cccaacttgc gtgttgtgcc
    12061 cgctggccgt atccctccca acccctcaga gcttttgggt tcccagcgta tgaaggcctt
    12121 gatggactac ctcaaggacg acgctatggt gatcatggac gccccgccgc tactgccggt
    12181 taccgacgcc ggtttgcttt cggccctggc cgacggcgcc atcttggtca tggaggtggg
    12241 tggcacctac aaggagcagg cccgtctgtg tggcaagatc ttcaagcagg ttgacggccg
    12301 tctgctgggt gtagtgctta accgtgcttc acgtcgtaac ctcggtagcg tttactacgg
    12361 ttacggctac ggtggctacg gccagaacta ctactactac gaagaagacg agaagcgtaa
    12421 gctgcttggc ttcatcccgc tgcctggtca ccgcaagcgc aagcgcgaaa accagatcgt
    12481 ctccatccaa gaggaagagg tccaccctct gcctaaggat aagcagagtc gccgctcctc
    12541 gcgccgcgct gcccgcagcg aggccccggc tcaggtaccc gctcagctac ctgccgccac
    12601 cattacctcg tctccagtta gctcgcgtac ctcagcggct agcccgcgtg tgagcacagt
    12661 ggttaacccc gagccggtaa gcgtgccttc cgtacaggat tcaggtgacg acaccgccac
    12721 cactgaggct gttgccagcc cggtaggtac cggtatgccg gtacctccac cagctgcctc
    12781 catcagccag ccggtgggtg aggaaactgc cgtgcagacc tccgccgcct ttggcgcccc
    12841 gcaggctagc gtgcccacgc gccgctcgct gcgtgagcgt cgcaatggct gatagctaat
    12901 acaacaaagg ccccggctta agccggggcc tttttgttta tcctgctaaa gctctgtaaa
    12961 gctcagtgaa tccctgtaaa gctcagtgaa gctcagctct aaagctcaga gaactgccag
    13021 gatttcggtt acgaacacta gggtgtcgcc gcccttaatg ccggcctggg gtacgccacg
    13081 ggagccgtaa cccagctcag aggggatgga cagtagtacg cgcgaaccta cgcgctggcc
    13141 taccaagccc tcatcccaac cacggataac catgcccacg ccaatctgga agctcagcgg
    13201 ctggccacgg tcaaaggagt tgtcgaatac ctggccgccc cagatctggc ccaggtagtt
    13261 gcacacgatg gtgtcgccgg gctcaacgat ctggccgtcg ccggcgtcga gaacctgaat
    13321 ctctaggtca gtgggggcct cagcgtcggg gaaggtgagg gtgggcttgg agcctttgct
    13381 accggaaacg gtaggaagcg gtgttgcgat catgccttaa gtttaaggta accaatgcct
    13441 caatgtatgt ttctacgcct gaagtagaat aggtgcgttc ctattttgac gcgctcgttt
    13501 ccccaacaag cttttcattt tcctgaggat actttgtggc ttccaatacc ggcatagtta
    13561 atttacctag gctaactagc ctacgtttct ttgctgcatc aggtgtattc atgtatcacc
    13621 tgtgccgtat ttatccaggc atgccgctta aagctacatc tactgtgggc tatgttgggg
    13681 tggcgttttt ctttgtgcta tcaggttttg tactgacctg gtccaccccg atttataacg
    13741 gtgtggaggc caagcaattt tggattaagc gtgtagcgcg tgtatacccc tcgcacctag
    13801 tgatgatggt tatcgcgttg ctgttgccgg ctacgccgct gccgctgacc tgggttgcgg
    13861 tacctcccaa cgcgctgctg ctgcaatctt ggttctcacc taatgacatt gcttttgggg
    13921 taaacgcagt tagctggtcg ctgtcttgtg aggctttctt ctacctgtgt gcgccgctac
    13981 tgatcagtgt gctaaacgca cttaagcccc tgcagcgcta cctagccgcc gccgctggtg
    14041 cgggcgtggc ctggagtatc ggcctggtgc tggcagctaa tgggtctaac gtttacgcct
    14101 accacttgcc gattgtgcgt atcggtgaat tcattatcgg tattgctttg gctctggctt
    14161 tgcgcgacgg cgtgcgcttg cctttcagga gcgtgtgtct tgcgggggtg accaccgctg
    14221 tgatggtgat ggtttgcctg cgcaccgggc agttgacgac ggttagcggc attttgatgg
    14281 tgcccgcctt tgcctggctg atttatgcct gcgcgcaggc tgacttggat ggggtacgcg
    14341 gcgtgctgcg gctaaagctg ctagagcaca tgggtattac gtcttttgct ttttatctgg
    14401 tgcacgaatt agtgctccta aacctcaaac cgctgccctg gccgcatggt tcaaagctgg
    14461 ttaatctggc gactgtaatc gtgctttgga ttatctgcca ggcggcggcg gaactgttat
    14521 accgtggagt tgagcgtcct gcgcagcgtc gtattcgtgc gtgggcggca gcacataagg
    14581 ggaagaatga aacaaaggct gggcattatt cgctacaacc tgggcgtgct agtggacaag
    14641 ccggaacgcc cggcactggt gtggatgatg ctgggaacgg tactagtgtc actggcggac
    14701 accgcctcga ttctgctggt agcgccgctg gcgcaggcca tgacgggaca gtggcgtagc
    14761 ggaaccgccg gatacgccgc taaactgctg gacgtaaata cccaaggtga gctggtagct
    14821 gccttagctg gcgcggttat tatcggcttc atcattaagg acctgctctc cattttggtg
    14881 cagtggtgga gtctgaaggt ttcctctaac ctgcgctata agagcgctat tgaaatcagc
    14941 gaatactatc tgcgcctgcc ttactctaag cacgcctatt tagggttggc ggtaattcta
    15001 aataagtctg gtcagaacgt gaccatggct tatagcggtt acctgtttgg cactatcacg
    15061 ctggctaccc agattttcgc ggttgtcagc gtggtggggg cactgctgat tgctgccccg
    15121 gtggctaccg cgattttggc gctgtttatc ggcctgtttg gctggctgtt cctgcgtaag
    15181 gtgcgcccgc taaacgagcg tctgggcgcg gaagaagtgg ccgctaatga gcgctcgttc
    15241 agggcttgtt ttgacgcttt tggcactatt aaagaaaccc agctgcgtaa cgcctacgac
    15301 ttctatctag aacgtattga tgaggcttca gctaagctgc gcgacattag cattcaaaag
    15361 ggtttcattg cttcactgcc taagcagcta attgaaattg tattcatgct ggcactagcc
    15421 atcgtgtttg cttttactgc ttttgtgggt gacagccagt cgctattgtc ctctatggcg
    15481 gtattgctag cggcggcttt ccgggtgcta cccactgctg ccggtatgct gggcaccttg
    15541 gctactatcc gtcaggctga gccggctacg cgcgaattta ttgcctctaa gctggccgcc
    15601 cgctcacaga ttaagagtat ggaaattgtt agccgtgagg aggtcacccc gctggttctg
    15661 cgtaaagagc tagaggtgcg tgacgtgcgt ttccgctatg acgacgacgc ccctgaggtg
    15721 cttaagggcg tggacttgcg tattcccttt ggcactaaag ctgcttttgt gggctcctcg
    15781 ggtgccggta aatctacttt gttggatctg ctgatggggc tgcaggtgcc caccagcggt
    15841 gagatcctga ttgacggcgc cgacatgcgt gaaaatattt acggctggca gtccaatatt
    15901 ggggtagtgc cccagaacgt gtttattact gaccgcacta ttgccgagaa tattgctttc
    15961 gaccagcgcc gcgaagacat tgaccccgag cgggtgcgcg aggctttgga aggcgcacgc
    16021 ctgtgggaat ttgtttctag ccagcctgaa ggtatctggt ctgagtttgg tgaacagggc
    16081 cgacgcctat caggtgggca gttgcagcgt gtgggtattg cccgcgcctt gtatcgccgt
    16141 cctaacctgc tgattttgga tgaggccact agcgccctag ataacgagac tgaagcggaa
    16201 atcgctgaaa ctatcgataa tctaagcggc aagatcaccg tgattattgt ggctcaccgc
    16261 ctgtccacta tccgtaatgc ggatcagatc gtgttcctgg ctaatggtgt ggttgatggt
    16321 atcggtagct tcattgagct gcaggagcgc tctgagggct tccgtaacct ggttaagttg
    16381 gcggctctag agcaggccta aaaccagcgc aaaacctaga atcagagcaa aataaggcca
    16441 gttgtttacc tggccgcagc cataaaaaag tttgtgcccc agaagtttct ggggcacaaa
    16501 cgcgtattag ctgtttagtt cacctgactc gttccaggtt ttccagcgca gcgggtgggc
    16561 tttaagcatg gggccgttag cagcaaactg gatgcgctca tcggggcgcc cgtggctgat
    16621 gttttcccaa acctcaagga tttcggcgtt ggatagcttg gagccagcct cccagtgtgg
    16681 ggagaaccag cttaggtcct cgccggtcag ggcggtggcg gcgctacctt gacgtacctt
    16741 gcgggctacc tgctcggggg agcggtattg ggcgtgggcg atttttaggc catggctggt
    16801 ggcgcctacc cgcagggcat agtggttgcc ggggcccatc tttagccagc ggtgtgaacg
    16861 cacggccacc ttaccgggga aggagggttt ggtgtccaca atgaattcgg cgttgatcag
    16921 gtcctcagga ccgggcgtgg tgggcaccat gtgtaaaaag tcggcgtaaa tcatgtctgc
    16981 gctttgggct cgcagatagt ctgctagccc cccttcggga gcgaaccaga actcgtcgcc
    17041 gtcgaaggga ataatccagt cagcccctgc ccgccaagcc gcatggcaca tgtaggtcat
    17101 tttttcggcc tgaatatgtg ccggttcgcg gtctcgggct acgtgcacgc ggccggtttt
    17161 gagggcgaat tcttctagaa tttccggggt gtcatcggtg gacatgttgt cgccaacaat
    17221 gatgtggctg atgccctgcg caaataggtg ctcaatgacc aggggcagga tatctgcctc
    17281 gtttttgact agcgttacgc cccaaacttc gccttcttta cgacgacgac gcggcaagtt
    17341 aggtagctgc atatgtttca tggcccgcat ctgcgcgggt aggctgcgat gcttaataaa
    17401 atccttgcaa acccagctgg cctgacccag atcttggcgt agtgacatta gcgtcctaag
    17461 gttggggtgg gaaagtgtca cgaggaaaaa cgtgactata ccgttgatag tatagattgg
    17521 tttccatccc acttatagcc cttgagaggt tggcgctatg ttggactatg gcagattcgt
    17581 ctataagtcg cgtgtgtggg ccggctatgc gaaccgagca attaaacgta gcttttctac
    17641 tcagcaggta aataaacgac gcgaaatttt aagctctcgc caggtgcctg acttcccggt
    17701 gactccaggc gcggttatgg ccgtaaccat ggttaaggat gaggctgaca tcattggccg
    17761 cgtcatcacc cacctgctgg agcaggaagt ggaccgggtg atcgtggctg acaatatgtc
    17821 tagcgatgac accccccaga ttttggctga gctggccagt gaatacccgg ttacggtggt
    17881 gcaagataac ctggcggcct actatcagtc agaaaaaatg acggccttgg ctaagttggc
    17941 gcgcaatcat ggggctaagt gggtaattcc tttcgacgcc gatgaactgt ggttcgctcc
    18001 gggcgccacc ctagctagct acctgcgggc tagcgacaag aaacagttcc gcgctgctgt
    18061 gcacaacgct atccccaccg aaaccgccgg ggtgtggcgt cttgatcagc gggcagcgag
    18121 cctgccgaaa actgctgtgg ccacgctacc tggcatgaat atttctatgg gtaaccactt
    18181 tgtggaccgc cctggtgaaa ccgacgccgg tatgcgccta attcacttgc cgtggcgttc
    18241 gctagagcag attgaacgta aatcaacgca gggttctttg gcgttgcgtt tggctgagca
    18301 tgaggggcgc ctggggcgcc agtggcatga gactgaaact gctctggcgc aggatgccgc
    18361 cgggctgtgg caggatctgc taaacggtaa cccgcacccg gccctggacc taaactggtc
    18421 ggcagacagt gagctaatca ccttagatga gctacctgct tggccttttg cccgtcccta
    18481 tgacatcacc ggccctaacc gcattgaaga ggtcaaatag gtagctgcgc tggcgcaggc
    18541 cgagcacccg tgaaagcctg cgacgttgag aagcttctta gctgcgctag cgcgggccaa
    18601 ggactttctt agccgcgagc gctgccagct gcctgtaggc tttgcccacc agctgcaagc
    18661 taataaaaac aagtgggggg cgtacctttt aggtacgccc cctgtgtgtt tgctgcgctt
    18721 agtgcgcgca gcgctatttg gcttagtcgt cgctgctgaa gatagccagc aggcgcagaa
    18781 tctcaatgta gagccacacc agggtcacta ccaggccgaa ggcgcaggtc caggcgtagc
    18841 ggcgaggagc gccggcgttt accagcgact cagtgttctg gaagtcgagc accagggaca
    18901 cagccgccat aatcacggca atggggccaa tgatcaggcc cagcgggatg cccgcaacgg
    18961 tcatggagta caggccaaac tcgccgccca ccaggccggt gagctgcagc aggaagttaa
    19021 ccatggcgaa agcgccgtaa ccgatcaggg caatcatgaa gatcttgagg aacttaccct
    19081 gcagacggaa gttagcgaac ttgtacaggc acagcattac tacgaacgtg gccaaagtac
    19141 ccagcacagc ctgcagcaca atgccgctgt agcgggttat ctcgacggcg gcagagaagc
    19201 caccaagcat tagaccttca gctacggcgt agatgaacat cagcaccggt gaaggctcac
    19261 gcttgaaggt gttgataaga ccgaagatca gcgccccaac agcgccggtg ctggtgacca
    19321 taacggcggt gcccatggcc tgtgcgctct gggcctggta ggcgttagcc accaggtacc
    19381 agccaaaagc agcggtgata actaccgtta gcagcagggc ggcggtacgc acaatgacgt
    19441 cgtcgtaagt catacgcccg gtctctacag cggaggcggc gggggcagcg tactgctgct
    19501 caagctgggc ctggccgtag gggtcggcgt aaccggtctg gccgtaagca ttctggtcgt
    19561 aagtattttg accataagcg ttctggccgt agggggcacc atagccgccc tggttggggt
    19621 ggccgggggt gtagccgggc atggtcggat acccggccgg ggtggtttgc tgcgcaccct
    19681 gcttgaatac agggttggag ctgaatacgg ggttggacat tagccccatc tccttccatt
    19741 tttcctggtc ccagcctgcc ataatgggga gatttaagct attaactcag ctagggactt
    19801 attcactatg ggagttttgg gcgcttttct ttgctctctc ctccctaagt aggagacggc
    19861 gtacaccttt agtctggcca ctttgccggc taagtttcct cacctaggcc gataaggctg
    19921 gggcagtggc ttcctagaat ttaagtcgta acaacgaaac ccagaaaggt taagcccatg
    19981 attcaggcgc gacacttaac caagcgctat ggcaacaaag tggctgtaaa cgatatctct
    20041 ttcgacgttc accccggtaa ggtgaccggc ttcctgggcc ctaacggtgc aggtaagtcc
    20101 accaccatgc gcatgattat gggccttgac cggcctacct ccggcgcggt gcgcgtaaac
    20161 ggccgcccct accgtgatct ggcggccccg ctaactgaag tgggtgccct actggacgcc
    20221 aagggcctgc acggttcacg cactgcccgt gcccacctca agcagctggc actttcaaac
    20281 ggtattcc
//
