LOCUS       NZ_KE386846            19040 bp    DNA     linear   CON 22-APR-2024
DEFINITION  Streptomyces flavidovirens DSM 40150 G412DRAFT_scaffold00009.9,
            whole genome shotgun sequence.
ACCESSION   NZ_KE386846
VERSION     NZ_KE386846.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces flavidovirens DSM 40150
  ORGANISM  Streptomyces flavidovirens DSM 40150
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 265539)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces flavidovirens DSM 40150
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: DSM 40150, ATCC 19900
            finishing_strategy                :: Level 1: Standard Draft
            GOLD Stamp ID                     :: Gi11969
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site                    :: Soil
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-03-07
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000429085.1-RS_2024_04_22
            Annotation Date                   :: 04/22/2024 01:37:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,525
            CDSs (total)                      :: 6,452
            Genes (coding)                    :: 6,216
            CDSs (with protein)               :: 6,216
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 236
            CDSs (without protein)            :: 236
            Pseudo Genes (ambiguous residues) :: 0 of 236
            Pseudo Genes (frameshifted)       :: 106 of 236
            Pseudo Genes (incomplete)         :: 173 of 236
            Pseudo Genes (internal stop)      :: 25 of 236
            Pseudo Genes (multiple problems)  :: 59 of 236
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 246499
            Orig. end                         :: 265539
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KE386846.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 1011953
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos   Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI
            Annotation by JGI
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..19040
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..19040
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..19040
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:16675](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16675
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(297..1238)
                     /locus_tag="G412_RS0131835"
     CDS             complement(297..1238)
                     /GO_function="GO:0008324 - monoatomic cation transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014049646.1"
                     /locus_tag="G412_RS0131835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation diffusion facilitator family transporter"
                     /protein_id="WP_028815571.1"
                     /transl_table=11
                     /translation="MGAGHDHGHTHGGPPPTGTAAAAYKGRLRIALGITLTVMTVEIVG
                     GLLANSLALIADAAHMATDALGLAMALLAIHFANRPATTKATFGYARAEILAALANCLL
                     LLGVGGFLLFEAVDRFITPAETKSGTAIVFALVGLVANMISLSLLMKGQKDSLNVRGAF
                     LEVLADTLGSVTVLVSAGIIMATGWQAADPIASLVIGLMIVPRTWKLLRETLSVLLEIA
                     PKGVDMAQVREHILDLPGVDDVHDLHAWTITSGMPVLSAHVVVSQDFLDSIGHEKMLHA
                     LQGCLGEHFDVEHCTFQLEPGGHAEHEAKLCH"
     misc_feature    1319..1333
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.72"
                     /tool="antismash"
     misc_feature    1349..1360
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(1381..2364)
                     /gene="galE"
                     /locus_tag="G412_RS0131840"
     CDS             complement(1381..2364)
                     /EC_number="5.1.3.2"
                     /GO_function="GO:0003978 - UDP-glucose 4-epimerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (58-207). E-value: 3e-11.
                     Score: 34.8. Matches aSDomain:
                     nrpspksdomains_G412_RS0131840_NAD_binding_4.1"
                     /codon_start=1
                     /gene="galE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888986.1"
                     /locus_tag="G412_RS0131840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="UDP-glucose 4-epimerase GalE"
                     /protein_id="WP_028815572.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 9e-19, bitscore:
                     61.5, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-15,
                     bitscore: 51.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWLITGGAGYIGAHVARTMAAAGERVVVLDDVSSGIPQRLPEDI
                     ALVRGSVLDRELLDRTLAEHGVTGVVHLAARKQVGESVEKPLLYYRENVYGLTVLLEAV
                     AAAGVRRFLFSSSAAVYGIPEAELISEDAPCVPINPYGETKLAGEWLVRAAGRAHGFST
                     ACLRYFNVAGAARPELADTGVFNIIPMFFDRITRGEAPRIFGDDYPTPDGTCVRDYIHV
                     ADLADAHLSVAQGLTARDEPADMTFNIGRGEGVSVRELADLVSEITGSTLAPVVEPRRP
                     GDAAKAVASSDLIAKELGWTAGRGVREMVASAWEGWLLRHPEAARN"
     aSDomain        complement(1744..2190)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G412_RS0131840_NAD_binding_4.1"
                     /evalue="3.00E-11"
                     /label="G412_RS0131840_NAD_binding_4.1"
                     /locus_tag="G412_RS0131840"
                     /protein_end="207"
                     /protein_start="58"
                     /score="34.8"
                     /tool="antismash"
                     /translation="DRTLAEHGVTGVVHLAARKQVGESVEKPLLYYRENVYGLTVLLEA
                     VAAAGVRRFLFSSSAAVYGIPEAELISEDAPCVPINPYGETKLAGEWLVRAAGRAHGFS
                     TACLRYFNVAGAARPELADTGVFNIIPMFFDRITRGEAPRIFGDD"
     CDS_motif       complement(2275..2361)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_G412_RS0131840_0001"
                     /evalue="4.20E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="G412_RS0131840"
                     /protein_end="30"
                     /protein_start="1"
                     /score="22.6"
                     /tool="antismash"
                     /translation="TWLITGGAGYIGAHVARTMAAAGERVVVL"
     misc_feature    complement(2426..2440)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            complement(2483..2803)
                     /locus_tag="G412_RS41310"
     CDS             complement(2483..2803)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G412_RS41310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_244283346.1"
                     /transl_table=11
                     /translation="MTDEARVDKGHPLTGGCLVEQLGGLLGGVAVGPGVPYDESQCPQI
                     ALERRSGYRRAGEDGGRQTNSLLGAGQGLGLAWHAALRPGTGAKACRQRLSDERKQEFM
                     AR"
     gene            2771..4399
                     /locus_tag="G412_RS0131845"
     CDS             2771..4399
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018552445.1"
                     /locus_tag="G412_RS0131845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5941 domain-containing protein"
                     /protein_id="WP_244283347.1"
                     /transl_table=11
                     /translation="MALVDPRFVGHVHSLRLALTDPRFPAAAAPGALTAQPAARAALAR
                     AVRGGAAGPDAAAAALDANGTVVRRPELGSLVAVVATDEDERVQARAAVAAVDEEAVRL
                     RTAVKSRDGFFTTFCVSPYSRYLARWCARRGFTPNQVTTASLITALIAAGCAATGTRGG
                     YVAAGALLLFSFVLDCTDGQLARYSLQYSTMGAWLDATFDRAKEYAYYAGLALGAARGG
                     DDVWALALGAMVLQTCRHVVDFSFNEANHDAESNTSPTAALSDKLDSVGWTVWVRRMII
                     LPIGERWAMIAVLTAVTTPRIVFYALLAGCALAALYTTAGRVLRSLTRAARRTDRAARA
                     LADLADSGPVARAVAARGPRLKGAWTAPVLAAAGAAALVATALTQPLGSRQMIIAAVCY
                     AVLCGTAVARPLKGALDWLVPPVFRAAEYGTILILAARSEVNGALPAAFGLVSAVAYHH
                     YDTVYRIRGGTGAPPQWLVRTIGGHDGRTLVVVVLATVLATRNTDLTLALAALAVAVAL
                     VVLVESIRFWVSSGAPAVHDEGEPA"
     gene            4396..5133
                     /locus_tag="G412_RS0131850"
     CDS             4396..5133
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955403.1"
                     /locus_tag="G412_RS0131850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphocholine cytidylyltransferase family
                     protein"
                     /protein_id="WP_028815574.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.3e-13, bitscore:
                     45.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIGLVLAAGAGRRLRPYTDTLPKALVPVDGETTVLDLTLGNFAEV
                     GLTEVAIVVGYRKEAVYARKEALEAKYGLKITLVDNDKAEEWNNAYSLWCAREVLKQGV
                     ILANGDTVHPVSVEKTLLAARGDGQKIILALDTVKNLADEEMKVITQDGKGVRRITKLM
                     DPATATGEYIGVTLIEPEAAEELADALKTTFERDPDLYYEDGYQELVNRGFTVDVAPIG
                     EVTWVEIDNHDDLAKGREIACQY"
     gene            5121..6182
                     /locus_tag="G412_RS0131855"
     CDS             5121..6182
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1181: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452391.1"
                     /locus_tag="G412_RS0131855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron-containing alcohol dehydrogenase family
                     protein"
                     /protein_id="WP_028815575.1"
                     /sec_met_domain="Fe-ADH (E-value: 8.9e-20, bitscore: 64.6,
                     seeds: 218, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 4.9e-10, bitscore:
                     32.8, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVLTRLIPSPVVVDISCGAMDDLAGLLADQRISASGKLAIATSG
                     GSGLPLRHKLAPVLPGADWYSVADGTIDSAVKLADEIKGKRYDAVVGLGGGKIIDVTKY
                     AAARVGLPMVAVATNLSHDGLCSPVSILDNDNGRGSYGVPTPIAMVIDLDVIRDAPVRF
                     IRSGIGDAISNISAIADWELSHRINGEPVDGLAAAMARTAGEAVLRHPGGVGTDEFLTV
                     LAESLVLSGIAMSISGDSRPSSGACHEISHAFDLLYPKRAASHGEQVGLGAAFAMHLRG
                     ATEQAGLFAEVLHRHGLPVLPEEIGFSVDEFVKAVAYAPQTRPGRFTILEHLDLSADQI
                     KDAYADYVKAISS"
     gene            6160..6939
                     /locus_tag="G412_RS0131860"
     CDS             6160..6939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008413838.1"
                     /locus_tag="G412_RS0131860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_078607584.1"
                     /transl_table=11
                     /translation="MSRPSVAELRPVVHPEGVKDRRSGEHWAGRMYMREISLHIDPYLV
                     NTKITPNQLTYLMVVVGVLGGAALLIPGLTGAILAVVLFQIYLLLDCVDGEVARWRKQT
                     SITGVYLDRIGHYLCEAALLVGFGLRGADLFGGGRPEWLWAFLGTLAALGAILIKAETD
                     LVDVARTRSGLPAVKDEASVPRSSGLALARRLAAALKFHRLVGGIEASLFILVVAIADF
                     VQGDLFFSRLGIAVLAGIAIVQTFLHLVSILASSRLK"
     gene            6936..7835
                     /locus_tag="G412_RS0131865"
     CDS             6936..7835
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018384775.1"
                     /locus_tag="G412_RS0131865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyltransferase"
                     /protein_id="WP_037650563.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.1e-15,
                     bitscore: 50.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAAGAASGLKVGAVIITMGNRPDELRALLDSVAKQDGDRVEVVV
                     VGNGSPVAGVPEGVRTVELPENLGIPGGRNAGIEAFGPSGAEMDILLFLDDDGLLAHHD
                     TAELCRQAFAADPKLGIISFRIADPDTGETQRRHVPRLRAADPMRSSRVTTFLGGANAV
                     RTKVFAEVGGLPDEFFYAHEETDLAWRALDAGWMIDYRSDMVLYHPTTAPSRHAVYHRM
                     VARNRVWLARRNLPAPLVPVYLGVWLLLTLARRPSVPALRAWFGGFKEGWTTSAGPRRP
                     MRWRTVWRLTRLGRPPVI"
     gene            7930..8865
                     /locus_tag="G412_RS0131870"
     CDS             7930..8865
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972239.1"
                     /locus_tag="G412_RS0131870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_028815578.1"
                     /transl_table=11
                     /translation="MSDTTRDGAVATSAPPSPDDGLTPAELAAKYGLSVSGARPGLIEY
                     VRQLWGRRHFILAFSQAKLTAQYSQAKLGQLWQVATPLLNALVYFLIFGLILEADRGMD
                     REVYVPFLVTGVFVFTFTQSSVMAGVRSISGNLGLVRALHFPRASLPISFALQQLQQLL
                     FSMIVLVIIAVAFGSYPSLSWLLVIPALAVQFVFNIGLALIMARLGSKTPDLAQLMPFV
                     MRTWMYASGVMFSIPAMLADKDLPGWVTDVLQWNPAAVYMDLIRFGLIDGYGSENLPPH
                     VWGVALGWALLVGLVGFVYFWKAEERYGRG"
     gene            8858..9643
                     /locus_tag="G412_RS0131875"
     CDS             8858..9643
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964853.1"
                     /locus_tag="G412_RS0131875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_028815579.1"
                     /transl_table=11
                     /translation="MADDNKQGRVPTVIADDVHIVYRVNAGAGGRGSATAALSRIMKRG
                     KGDSPGVRKVHAVRGVSFTSYRGEAIGLIGTNGSGKSTLLRAIAGLLPTEQGKVYTDGQ
                     PSLLGVNAALMNDLTGERNVILGGLAMGMTREEIRERYQQIVDFSGINEKGDFITLPMR
                     TYSSGMAARLRFSIAAAKDHDVLMIDEALATGDRKFQIRSEQRIRELRKEAGTVFLVSH
                     SNKSIRDTCDRVLWLEKGELLMDGPTDEVLKAYEKETGR"
     gene            10001..10903
                     /gene="hpnC"
                     /locus_tag="G412_RS0131880"
     CDS             10001..10903
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005308894.1"
                     /locus_tag="G412_RS0131880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene synthase HpnC"
                     /protein_id="WP_028815580.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.2e-38, bitscore:
                     125.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.2e-40,
                     bitscore: 132.1, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTRHVRTDAHARTTLDKAADENFPVAPFFLPRAWRDDLMAVYG
                     YARLVDDIGDGDLAPGGADARLLGLDPALADDRLLLLDAFEADLRRVFDASGDGPRHPL
                     LRALVPTVRRCSLTPGPFLGLIEANRQDQLVRRYKTYDDLLAYCELSANPVGRLVLQIT
                     GTASPERIRRSDAVCTALQIVEHLQDVAEDLGRDRIYLPADTMARFHVEEADLAAPSAN
                     ASVRSLIAYEAERAGRLLDEGTPLVASVSGRLKLLLAGFAGGGRAALAAIAATGYDVLP
                     GPPKPTKLSLLRAVGAVLR"
     gene            10948..11868
                     /gene="hpnD"
                     /locus_tag="G412_RS0131885"
     CDS             10948..11868
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944204.1"
                     /locus_tag="G412_RS0131885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_106964213.1"
                     /sec_met_domain="phytoene_synt (E-value: 9.2e-59, bitscore:
                     192.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 2.7e-70,
                     bitscore: 230.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPVLAAYSYCEAVTGAQARNFAYGIRLLPTDKRNAMSALYAFS
                     RRVDDIGDGVLEPAVKQVRLEETRALLDRIRTGAVDDDDTDPVAVALSDTARRFPLPLE
                     GLDELIDGVLMDVRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTQTGARSTERASEYA
                     DTLGLALQLTNILRDVREDAGNGRTYLPADDLAKFGCSAGFHGATPPEGSDFTGLIHFE
                     VRRARALFAEGYRLLPLLDRRSGACVAAMAGIYRRLLDRIERDPLAVLRGRVSLPGHEK
                     AYVAVRGLSGLDSRHISRSHIWRRV"
     gene            11996..13426
                     /gene="hpnE"
                     /locus_tag="G412_RS0131890"
     CDS             11996..13426
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568730.1"
                     /locus_tag="G412_RS0131890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_078607571.1"
                     /sec_met_domain="DAO (E-value: 1.3e-11, bitscore: 38.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRGTTGGRSVVPARSPGPAAGHAVVVGGGLAGVTAALQLADAGM
                     RVTLLEGRPRLGGLAFSFRRGELTVDNGQHVYLRCCTAYRWFLDRVEGAGLAPLQSRLD
                     VPVLDVGRPAGPRLGRLRRTALPVPLHLAASLAAYPHLSLAERASVGRAALALKKLDPA
                     DPALDGVDFATWLGRHGQSPRTIEALWDLVGVATLNATAPDASLGLAAMVFKTGLLSDP
                     GAADIGWAHVPLGDLHDTLARKALDSAGVRTALRTRVSSLSRSVSGGWSVGTAAGERIE
                     ADAVVLAVPQRETHAVLPEGVIDDPGRLLDIGTAPILNVHVVYDRKVLRRPFFAALGSP
                     VQWVFDRTESSGLRGGGQYLAVSQSAARGEIDAPVAELRARYLPELERLLPAARGAGVR
                     DFFVTRERTATFAPTPGVGRLRPGARTHAPGLYLAGAWTATGWPATMEGAVRSGITAAG
                     AALRELGRVHEHPLQEAV"
     gene            13423..14517
                     /locus_tag="G412_RS0131895"
     CDS             13423..14517
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964849.1"
                     /locus_tag="G412_RS0131895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_051338738.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.1e-59, bitscore:
                     195.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTGMETRGEPVTPVNPVDNTTVDIAALLERGRTLSTPVLKAAVG
                     RLAPPMDTVAAYHFGWIDAQGRPADGDGGKAVRPALALLSAQAAGAAAEVGVPGAVAVE
                     LVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALANEVLLELGTVEAGR
                     ATRRLTTATRKLIDGQAQDISFEHRERVTVEECLEMEGNKTGALLACAVSIGAVLGGAD
                     DRTADTLEAYGYHLGLAFQAVDDLLGIWGDPDATGKQTWSDLRQRKKSLPVVAALAAGG
                     PASERLGELLSADAKSNDFESFSEQEFATRAALIEEAGGRDWTAQEARRQHAVAIEALD
                     GVDMPPQVRAQLTALADFVVVRKR"
     misc_feature    14528..14544
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            14639..16675
                     /gene="shc"
                     /locus_tag="G412_RS36970"
     CDS             14639..16675
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020116600.1"
                     /locus_tag="G412_RS36970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_051338744.1"
                     /sec_met_domain="T2TS (E-value: 4.3e-151, bitscore: 498.0,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSPGAMKPCAAAASEFTDNNTNTTTTEITRHGPVIAGVL
                     DAARRATDRGVAHLLAQQDDQGWWKGDLETNVTMDAEDLLLRQFLGIQDEKTVRAAALF
                     IRGEQRGDGTWATFYGGPGDLSTTIEAYVALRLAGDLPDAPHMERAAAWIRARGGIAAS
                     RVFTRIWLALFGWWKWDDLPELPPELIFLPSWFPLNIYDFGCWARQTIVPLTVVSAKRP
                     VRPAPFALDELHANPRVPNPRKRLSTPTSWEGAFQRLDKALHVYRKVAPARLRGAAMKS
                     AARWIVERQENDGCWGGIQPPAVYSLIALHLLGYDLDHPVMRAGLESLDRFTVWREDGA
                     RMIEACQSPVWDTCLATIALADAGVRPDDPALVKAADWMMSEQIVRPGDWAVRRPGVEP
                     GGWAFEFHNDNYPDIDDTAEVVLALRRVAHPDRARTEATVDRAVRWNLGMQSKNGAWAA
                     FDADNTSPFPNRLPFCDFGEVIDPPSADVTAHVVEMLAVEGKAHDPRTRRGIEWLLAEQ
                     EPSGAWFGRWGVNYVYGTGAVVPALIAAGLPAAHPAVRRAVGWLESVQNDDGGWGEDLR
                     SYREAGWAGRGASTASQTAWALLALLAAGERDGRSVERGVAWLAGTQREDGSWDEPYFT
                     GTGFPWDFSINYHLYRQVFPLTALGRYVHGEPTYPDLATREGT"
     gene            16675..17355
                     /locus_tag="G412_RS0131905"
     CDS             16675..17355
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152780.1"
                     /locus_tag="G412_RS0131905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="1-hydroxy-2-methyl-2-butenyl 4-diphosphate
                     reductase"
                     /protein_id="WP_244283348.1"
                     /transl_table=11
                     /translation="MAPMDPADRTDPADEPPRPAPLLIACALGIEQFALRSGHRKEAPG
                     PVTVLRTGMGPKAAATAVRQALAHGGPAPDAAVIASGFCAGLVPGMHPGDLIVADETRG
                     PHGTSACTGVELLAKALDRVVPGRTVHTGPLLGSAHVVRGPERARLAATGAIAVDMESA
                     ATLGSALRAGPRPVAAVRVVVDAPEHELVRIGTLRGGISAFRVLRAVLPAFFEWHRSSL
                     LPRR"
     gene            17361..18383
                     /gene="hpnH"
                     /locus_tag="G412_RS0131910"
     CDS             17361..18383
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037634.1"
                     /locus_tag="G412_RS0131910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_028815585.1"
                     /sec_met_domain="PF04055 (E-value: 2.4e-19, bitscore: 64.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 9.3e-10, bitscore: 32.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQTIRVGTYLVEQKLRKREKFPLIVELEPLYACNLACEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF
                     LCTNAMLLRKKIEKFTPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKKRGF
                     RVTTNSTFFNTDTPQTIIEVLNYLNDDLEVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FKKAFAGGNRRRWRLNHSPLFLDFLEGKADFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEETDWSKYGRGKDPRCANCMAHCGYEPTAVLATMGSLKESLRAVRETVSGNHG
                     "
     misc_feature    17408..17421
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            18388..>19040
                     /locus_tag="G412_RS0131915"
     CDS             18388..>19040
                     /EC_number="1.17.7.3"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356627.1"
                     /locus_tag="G412_RS0131915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_028815586.1"
                     /transl_table=11
                     /translation="MTLGEPVALGLPELPARPLAVRRASRRIQVGSVAVGGDAPVSVQS
                     MTTTRTSDVGATLQQIAELTASGCQIVRVACPTQDDADALATIARKSQIPVIADIHFQP
                     KYVFAAIDAGCAAVRVNPGNIKQFDDKVKEIAKAASETRTPIRIGVNAGSLDARLLQKY
                     GKATPEALVESALWEASLFEEHGFGDIKISVKHNDPVVMVNAYRQLAAQCDYPL"
ORIGIN
        1 gcgcgcttcg gcggcgctcc gcagctcggc gaggaacggc tcgtacagat cgacggccgt
       61 cacctcggcg ccgcactccc cggccagcag cagcgagacc ctgcccggac cgcagcccag
      121 gtcgagcacg cgcggccggt gcggcagcgg tccggcgagg gagagcagat ggcgggcggt
      181 ggcgtcggag ccggggccct ggcggggcag cccgcggtgc agggtcatga aagcttcgaa
      241 catggcgttg tcgctcaacg taagaaccct ttggtgtgcc tgacagtacc ggcggatcag
      301 tggcagagct tcgcctcgtg ctcggcgtga ccgccgggct ccagctggaa cgtgcagtgc
      361 tcgacgtcga agtgctcccc gaggcagccc tggagggcat gcagcatctt ctcgtgcccg
      421 atcgagtcga ggaagtcctg gctgacgacg acatgcgccg acaggaccgg catgcccgag
      481 gtgatcgtcc aggcatgcag atcgtgtacg tcgtcgacgc ccggcagatc gagtatgtgc
      541 tcccgcacct gcgccatgtc cacgcccttg ggcgcgatct ccaggagcac gctcagcgtc
      601 tcccgcagca gcttccaggt gcgcggcacg atcatgaggc cgatcaccag cgacgcgatg
      661 gggtcggcgg cctgccagcc ggtcgccatg atgatgccgg ccgagaccag cacggtgacc
      721 gagcccaggg tgtccgcgag cacctccagg aaggcgccgc gcacattgag actgtccttc
      781 tggcccttca tcagcaggga cagcgagatc atgttggcga cgagaccgac cagggcgaag
      841 acgatcgccg taccgctctt ggtctcggcc ggggtgatga agcggtcgac ggcctcgaag
      901 agcaggaaac cgccgacacc gagcagcagc agacagttgg cgagtgcggc gaggatctcg
      961 gccctggcgt acccgaaggt ggccttcgtg gtggccgggc ggttggcgaa gtggatggcc
     1021 aggagcgcca tcgcgaggcc gagggcgtcc gtcgccatat gggccgcgtc cgcgatcagc
     1081 gccagcgaat tggcgagcag accgccgacg atctcgaccg tcatgacggt cagggtgatg
     1141 ccgagcgcga tacgaagccg ccccttgtac gcggcggccg ctgtgccggt gggcggcggc
     1201 cccccgtgcg tatgcccgtg atcgtgccca gcccccatga aggatgcctc cccagtggtg
     1261 tgaatggtct gccgaggagc cagtgaacta cgggcggggg gtatgcgcaa cacgggactg
     1321 aacaccgttg tcatatgctc tgacctgcgg aaatgaccgc aggtcagagc ggcgacctga
     1381 tcagttccgg gcggcctcgg ggtgccggag cagccagccc tcccacgccg aggcgaccat
     1441 ctcgcgcacc ccgcgcccgg ccgtccagcc cagctccttg gcgatcagat cggacgaggc
     1501 gaccgccttc gccgcgtcgc cggggcggcg cggctcgacc accggggcga gcgtggaacc
     1561 ggtgatctca ctcaccagat cggcgagctc gcgcaccgag acgccctcac cgcggccgat
     1621 gttgaaggtc atgtccgccg gctcgtcccg cgcggtcagc ccctgtgcga ccgacaggtg
     1681 ggcatcggcg agatcggcga cgtgaatgta gtcacggacg caggtgccgt cgggcgtcgg
     1741 atagtcgtcc ccgaagatcc gcggggcctc gccgcgcgtg atccggtcga agaacatcgg
     1801 aatgatgttg aacactccgg tgtcggcgag ctccggcctc gccgcgcccg ccacattgaa
     1861 gtagcgcaga cacgcggtcg agaagccgtg cgcccggccc gcggcccgca cgagccactc
     1921 gccggccagc ttcgtctcgc cgtacggatt gatcgggacg cagggggcgt cctccgagat
     1981 gagctccgcc tcgggaatgc cgtacacggc ggcggaggag gagaagagga accgccgcac
     2041 cccggccgcc gcgacggcct ccaggagcac ggtgagtccg tacacatttt cccggtagta
     2101 gagcagcggc ttctcgaccg actccccgac ctgcttcctc gccgcgagat gcaccacacc
     2161 tgtgacgccg tgctccgcga gcgtacggtc gagcagctcc cggtccagta cggagccgcg
     2221 taccagcgcg atgtcctcgg gcagccgctg cgggatgccg gacgagacgt cgtccaggac
     2281 gaccacccgc tcacccgccg ccgccatggt ccgcgccaca tgcgcgccga tgtaacccgc
     2341 cccacccgtg atcagccatg tcataacggc caccctaggg cgtgtccgga cctcaggcgg
     2401 tcgcggtttg tggggcgggg cgctgatcga gcaagatgat ctcggtgggg cgcccgcgtc
     2461 ctggcccggt cttatccggg cgttaacggg ccatgaactc ctgcttccgt tcatccgata
     2521 gcctctgccg acatgccttc gcgcccgtgc cgggccgcaa tgccgcatgc cacgcaaggc
     2581 caagcccctg cccagcgcca aggagtgagt tcgtctgccg accgccatcc tcaccggccc
     2641 gccggtaccc ggatcgccgc tcgagggcga tctgcgggca ctgggattcg tcgtacggta
     2701 cgccgggccc gacggcgacg ccgccgagca gaccgccaag ctgctcgacg agacacccgc
     2761 cggtgagcgg gtggcccttg tcgacccgcg cttcgtcggt cacgtccact ccctgcgcct
     2821 cgcgctgacc gacccccgct tcccggccgc cgcggccccc ggcgcgctca ccgcgcagcc
     2881 cgcggcccgc gccgcgctgg cccgcgccgt gcgcggcggc gccgccgggc ccgacgccgc
     2941 cgccgccgcg ctcgacgcga acggcaccgt cgtgcggcgg ccggagctcg gctcgctggt
     3001 cgccgtcgtc gccacggacg aggacgagcg cgtgcaggcc cgcgccgccg tcgccgccgt
     3061 cgacgaggag gccgtacggc tgcgtacggc cgtgaagtcc cgcgacggtt tcttcaccac
     3121 cttctgcgtc agcccgtact cgcgctacct cgcgcgctgg tgcgcccgca ggggcttcac
     3181 cccgaaccag gtcaccacgg cctcgctgat caccgcgctg atcgcggccg gctgcgcggc
     3241 gaccggtacc cgcggcggct acgtcgcggc cggcgcgctg ctgctcttct ccttcgtcct
     3301 ggactgcacc gacgggcagc tcgcccgcta ctcgctccag tactcgacga tgggcgcctg
     3361 gctcgacgcg accttcgacc gcgccaagga gtacgcgtac tacgcgggcc tcgcgctcgg
     3421 cgccgcccgt ggcggggacg acgtatgggc gctggcgctc ggcgcgatgg tgctccagac
     3481 ctgccgccat gtcgtggact tctccttcaa cgaggcgaac cacgacgcgg agtccaacac
     3541 cagccccacc gccgcgctct ccgacaaact cgacagcgtc ggctggacgg tctgggtgcg
     3601 ccggatgata atcctgccga tcggcgagcg gtgggcgatg atcgcggtac tgaccgccgt
     3661 caccaccccg cggatcgtct tctacgccct gctcgccggc tgcgcgctcg ccgccctcta
     3721 caccacggcc ggccgcgtcc tgcgctcgct gacccgcgcg gcacggcgta ccgaccgggc
     3781 ggcccgggcc ctcgccgacc tcgcggacag cgggcccgtc gcccgggcgg tggcggcccg
     3841 tgggccgcgc ctcaagggcg cctggaccgc ccccgtcctc gccgccgccg gcgccgccgc
     3901 cctggtggcc acggcgctca cccagcccct cggcagccgc cagatgatca tcgcggcggt
     3961 ctgctacgcc gtgctctgcg gcacagccgt cgcgcggccc ctcaagggcg ccctcgactg
     4021 gctcgtcccg cccgtcttcc gggcagccga gtacggcacg atcctgatcc tggccgcccg
     4081 ctccgaagtg aacggagcgt tgccggccgc attcgggctg gtgtcggcgg tcgcctacca
     4141 tcactacgac accgtgtacc gcatccgcgg cggcacgggc gcgccgcccc agtggctggt
     4201 gcggacgatc ggcgggcacg acggccggac gctggtggta gtggtactcg ccaccgtcct
     4261 ggcgacgcgg aacacagacc tcaccctggc gctcgcggcc ctcgctgtgg ccgtggcact
     4321 cgtggtgctg gtggagtcca tccgcttctg ggtgtcctcc ggagcacccg cggtacatga
     4381 cgaaggagaa cccgcatgat cggcctcgta ctggctgccg gcgccggacg gcgtctgcgt
     4441 ccctacacgg acaccctccc gaaggccctg gtgcccgtgg acggtgagac gaccgtcctc
     4501 gacctgacgc tgggcaactt cgccgaggtc ggcctgaccg aggtcgccat cgtcgtcggc
     4561 taccgcaagg aggccgtcta cgcgcgcaag gaggcccttg aggcgaagta cggcctcaag
     4621 atcacgctcg tcgacaacga caaggccgag gagtggaaca acgcctactc cctgtggtgc
     4681 gcgcgtgagg tcctcaagca gggcgtgata ctcgccaacg gcgacaccgt tcacccggtc
     4741 tccgtcgaga agacgctgct cgccgcccgc ggcgacggcc agaagataat cctcgccctc
     4801 gacacggtga agaacctcgc cgacgaggag atgaaggtca tcacgcagga cggcaagggt
     4861 gtccggcgga tcaccaagct gatggacccg gccaccgcca ccggtgagta catcggtgtc
     4921 acgctcatcg agccggaggc cgccgaggag ctggccgacg cgctgaagac gacgttcgag
     4981 cgcgaccccg acctctacta cgaggacggc taccaggagc tggtcaaccg cggcttcacc
     5041 gtcgacgtgg cccccatcgg cgaagtgacg tgggtcgaga tcgacaacca cgacgacctc
     5101 gcgaagggcc gtgagatcgc gtgccagtac tgacccggct catcccgtca ccggtcgtcg
     5161 tcgacatcag ctgcggcgcc atggacgacc tggccggcct gctggccgac cagcggatct
     5221 ccgcctccgg caagctggcg atcgcgacca gcggcggctc gggcctgccc ctgcgccaca
     5281 agctcgcgcc ggtcctgccg ggcgccgact ggtactccgt cgccgacgga acgatcgact
     5341 ccgccgtgaa gctcgccgac gagatcaagg gcaagcggta cgacgccgtg gtcggcctcg
     5401 gcggcggcaa gatcatcgac gtcacgaagt acgcggcggc gcgggtcggc ctgccgatgg
     5461 tcgccgtcgc gacgaacctc tcgcacgacg gtctctgctc gccggtgtcc atcctggaca
     5521 acgacaacgg gcgcggctcc tacggcgtac cgacccccat cgccatggtc atcgacctcg
     5581 atgtgatccg cgacgccccg gtccgcttca tccggtccgg catcggtgac gcgatctcca
     5641 acatctcggc aatcgcggac tgggagctgt cccaccgtat aaacggcgag ccggtcgacg
     5701 gactggccgc cgccatggcc cgtacggccg gagaagccgt actccgccac cccggcggcg
     5761 tcggcaccga cgagttcctc acggtcctcg ccgagtccct cgtcctgtcc ggtatcgcca
     5821 tgtcgatcag cggcgacagc cgcccctcgt ccggtgcgtg ccacgagatc agccacgcct
     5881 tcgacctgct gtaccccaag cgggccgcga gccacggcga gcaggtcggc ctcggcgcgg
     5941 ccttcgccat gcacctgcgg ggcgccaccg agcaggccgg gctcttcgcc gaggtactgc
     6001 accggcacgg cctgccggtg ctcccggagg agatcggctt cagcgtcgac gagttcgtca
     6061 aggccgtcgc ctacgcacca cagacccgtc cgggacgctt cacgatcctg gaacacctcg
     6121 acctgtccgc agaccagatc aaggacgctt acgccgacta tgtcaaggcc atcagtagct
     6181 gaactccgtc cggtcgttca ccccgagggc gtgaaggacc ggcgcagcgg tgagcactgg
     6241 gccgggcgca tgtacatgcg ggagatctcg ctgcacatcg acccgtacct ggtgaacacc
     6301 aagatcacgc cgaaccagct cacgtacctc atggtcgtcg tgggtgtgct cggcggcgcg
     6361 gccctgctga tccccggcct gaccggtgcg atcctcgcgg tggtcctgtt ccagatctat
     6421 ctgctgctcg actgtgtcga cggcgaggtc gcccgctggc gcaagcagac ctcgatcacg
     6481 ggcgtctacc tggaccgcat cggccactac ctgtgcgagg cggccctgct cgtgggcttc
     6541 ggcctgcgcg gcgccgacct gttcggcggc ggacggcccg agtggctgtg ggcgttcctc
     6601 ggtacgctcg ccgcgctggg cgcgatcctg atcaaggccg agaccgacct ggtcgacgtc
     6661 gcccgtacgc gcagcggtct gcccgccgtg aaggacgagg cctccgtgcc gcgctcctcc
     6721 ggtctggccc tggcgcgcag gcttgccgcg gcgctgaagt tccaccgcct ggtcggcggc
     6781 atcgaggcga gcctgttcat cctggtcgtc gcgatcgccg acttcgtcca gggcgatctg
     6841 ttcttctccc gtctcgggat cgccgtcctc gcgggcatcg cgatcgtgca gacgttcctg
     6901 cacctcgtgt ccatcctcgc ttcgagcagg ctgaagtgac ggccgcgggc gcggcctccg
     6961 gcctgaaggt cggcgccgtc atcatcacga tgggcaaccg ccccgacgag ctgcgcgccc
     7021 tcctggactc ggtcgccaag caggacggcg accgggtcga ggtcgtcgtc gtcggcaacg
     7081 gctccccggt cgccggtgtc cccgagggcg tacggaccgt cgagctgccc gagaacctcg
     7141 gcattccggg cggccgcaac gccggcatcg aggcgttcgg ccccagcggc gccgagatgg
     7201 acatcctgct cttcctcgac gacgacggcc tgctggccca ccacgacacg gccgagctgt
     7261 gccgccaggc cttcgccgcc gacccgaagc tcggcatcat cagcttccgg atcgcggacc
     7321 ccgacacggg cgagacccag cgccgccacg tcccgcggct gcgcgcggcc gacccgatgc
     7381 gctcctcacg cgtgacgacc ttcctcggcg gcgccaacgc cgtacgcacc aaggtcttcg
     7441 ccgaggtcgg cgggctgccg gacgagttct tctacgccca tgaggagacc gatctggcct
     7501 ggcgggcgct cgacgcgggc tggatgatcg actaccgctc ggacatggtc ctgtaccacc
     7561 cgacgaccgc tccttcccgg cacgccgtct accaccgcat ggtggccagg aaccgggtct
     7621 ggctggcacg gcgcaacctg ccggcccccc tggtgcccgt ctacctcggc gtatggctgc
     7681 tgctcaccct cgcgcggcgc ccctccgtac ccgctctgag agcatggttc ggcggcttca
     7741 aggaggggtg gacgacctca gcgggtccgc gccgtccgat gagatggcgt accgtctggc
     7801 gactgacccg gctcggccga cctcctgtca tctgacaagc tcgggtctga aagcatcggg
     7861 ggcacgcggg acgtgtgccc ggtcctgcgc cttactgcct gcgcatcttg aacacgaaag
     7921 tttcaacttg tgagtgacac aacccgtgac ggtgcggtcg cgacgagcgc cccgccatct
     7981 cccgacgacg gacttacccc ggcggagctc gccgcgaagt acggcctgtc ggtgagcggt
     8041 gcccggccgg ggctgatcga gtacgtccgg cagctgtggg gccggcgcca cttcatcctc
     8101 gcgttctcgc aggcgaagct gaccgcccag tacagccagg ccaagctcgg ccagctgtgg
     8161 caggtggcga ctccgctgct gaacgccctc gtgtacttcc tcatcttcgg cctgatcctg
     8221 gaggccgaca ggggcatgga ccgggaggtg tacgtcccct tcctggtcac cggtgtgttc
     8281 gtcttcacct tcacccagag ctcggtgatg gccggtgtcc ggtccatctc gggcaacctg
     8341 ggcctggtca gagcgctgca cttcccgcgt gcctcgctgc cgatctcctt cgcgctccag
     8401 cagctccagc agctgctgtt ctcgatgatc gtgctggtga tcatcgcggt ggcgttcggc
     8461 agctacccct cgctctcctg gctgcttgtc atccccgcgc tggccgtgca gttcgtcttc
     8521 aacatcggcc tcgcgctgat catggccagg ctcgggagca agacccctga cctcgcccag
     8581 ctcatgccct tcgtgatgcg tacgtggatg tatgcctccg gagtgatgtt cagcatcccg
     8641 gccatgctgg ccgacaagga cctgcccggc tgggtcacgg acgtgctcca gtggaacccg
     8701 gcggccgtct acatggatct catccgtttc ggcctgatcg acggctacgg ctccgagaac
     8761 ctgcccccgc acgtctgggg cgtcgccctg ggctgggcgc ttctcgtggg cctcgtgggc
     8821 ttcgtgtact tctggaaggc tgaggagagg tacggccgtg gctgacgaca acaagcaggg
     8881 acgcgtcccc accgtcatcg cggacgacgt gcacatcgtg taccgcgtca acgccggcgc
     8941 gggcgggcgc ggcagcgcca ccgccgccct gagccgcatc atgaagcgcg gcaagggcga
     9001 ctcgcccggc gtacgcaagg tgcacgcggt gcgcggtgtc tccttcacgt cctaccgggg
     9061 cgaggcgatc ggcctgatcg gcaccaacgg gtcgggcaag tcgaccctgc tgcgcgccat
     9121 cgcgggcctc ctgccgaccg agcagggcaa ggtctacacg gacggccagc cctcactcct
     9181 cggtgtgaac gcggcgctga tgaacgacct gaccggcgag cgcaacgtca tcctcggcgg
     9241 cctcgccatg ggtatgacac gtgaggagat ccgcgagcgc tatcagcaga tcgtcgactt
     9301 ctcgggtatc aacgagaagg gcgacttcat caccctgccg atgcgcacgt actcctccgg
     9361 catggccgcc cgtctgcgtt tctccatcgc cgccgccaag gatcacgacg tactgatgat
     9421 cgacgaggcg ctggcgacgg gcgaccggaa gttccagatc cgctccgaac agcgcatccg
     9481 cgagctccgc aaggaggccg gcacggtctt cctggtcagc cacagcaaca agtcgatcag
     9541 ggacacctgt gaccgcgttc tgtggctgga gaagggcgag ctgctgatgg acggtcccac
     9601 ggacgaggtc ctcaaggcct acgagaagga aaccggccgc tagagcgggt cctgcgggcg
     9661 cggtgccccc gccgggccgc cccggcgggg gtttcgcgtg tccgggtgca ccctttccgc
     9721 gtttccgtgc ggcgcgagcg gcccggcgcg ccgtaacatg ccggaatcgt caactccggc
     9781 cacttacggg aaggttgagg catatcgcag cgttgttgtc atccgcccaa caccccggcg
     9841 cggtgccggg cgttgtacaa cgtaagctgt accggtgggc ggcgtgtccg aaatgggatg
     9901 tattaggtcg acggtgtaga acgggagatg tgacggcaat ggcgatggaa tctctccagc
     9961 tcgaagacgc ttccgccgtc cccgcaccgg gcagcccgcg atgaccacaa cccgtcacgt
    10021 gcgcaccgac gcacacgcgc gcacgaccct ggacaaggcc gccgacgaga acttcccggt
    10081 ggctcccttc tttctgccgc gcgcctggcg ggacgacctg atggccgtct acggctacgc
    10141 ccgcctcgtc gacgacatcg gcgacggcga cctcgccccc ggcggcgccg acgcccgcct
    10201 gctcggcctc gaccccgccc tcgccgacga ccgcctgctc ctgctcgacg ccttcgaggc
    10261 cgacctgcgc cgcgtcttcg acgcctcggg agacggcccg cgccaccccc tcctgcgcgc
    10321 cctcgtgccg accgtgcgcc gctgctcgct cacccccggc ccgttcctcg ggctcatcga
    10381 agccaaccgg caggaccagc tcgtacgccg ctacaagacg tacgacgatc tcctcgcgta
    10441 ctgcgagctg tcggcgaacc ccgtcggccg gctcgtcctc cagatcaccg gcaccgcgag
    10501 ccccgagcgg atccgccgct ccgacgcggt ctgcaccgcc ctgcagatcg tcgaacacct
    10561 ccaggacgtc gccgaggacc tcggccgcga ccggatctac ctgcccgccg acaccatggc
    10621 gcgcttccat gtcgaggagg ccgatctggc cgcgccgtcc gcgaacgcgt cggtgcgctc
    10681 cctgatcgcg tacgaagcgg aacgcgccgg gcgcctcctg gacgagggca ctccgctcgt
    10741 ggccagtgtc agcggcaggc tcaagctgct cctcgccggt ttcgccggcg gcggccgcgc
    10801 ggccctcgcg gcgatcgcgg ccaccggcta cgacgtgctc cccggaccgc ccaagcccac
    10861 caagctcagc ctgctgcgcg cagtgggagc tgtcttgcga tgagaccgaa gagaggggtg
    10921 agccggcccg tggaaggact cacgcagatg tccgcaccgg tactcgccgc gtacagctac
    10981 tgcgaggccg tgaccggagc gcaggcgcgc aatttcgcgt acggcatcag gctgctgccg
    11041 accgacaagc gcaacgccat gtccgcgctg tacgcgttct cacggcgcgt ggacgacatc
    11101 ggcgacggtg tgctggagcc cgccgtcaag caggtgcggc tcgaagagac ccgcgcactg
    11161 ctcgaccgga tccggacggg cgccgtcgac gacgacgaca ccgacccggt cgccgtggcg
    11221 ctctcggaca cggcgcgccg cttcccgctg ccgctcgaag ggctcgacga actcatcgac
    11281 ggcgtcctca tggacgtacg cggcgagacc tacgagacct gggacgacct gaaggtctac
    11341 tgccggtgcg tcgcgggcgc catcggacgg ctctcgctgg gcgtgttcgg cacccagacc
    11401 ggcgcgcgct ccacggaacg cgcctcggag tacgccgata cactcggtct cgccctccag
    11461 ctgaccaaca tcctccggga cgtccgcgag gacgccggga acgggcgtac ctacctgccc
    11521 gccgacgacc tcgccaagtt cggctgctcg gccggtttcc acggcgccac cccgcccgaa
    11581 gggtccgact tcacgggcct gatccacttc gaagtacgcc gcgcccgcgc cctgttcgcc
    11641 gagggctacc ggctgcttcc cctgctcgac cggcgctccg gcgcctgcgt cgccgcgatg
    11701 gccggcatct accggcggct ccttgaccgc atcgagcgcg accccctggc cgtactgcgc
    11761 ggccgggtct ccctgccggg acacgagaag gcgtacgtcg ccgtgcgcgg cctgtcgggc
    11821 ctcgactccc ggcacatctc ccgcagtcac atctggaggc gggtctgatg ggccccgttg
    11881 cggccggcgg gacgaacgcg tacaagagag gcgcaacccc ccggcggccc ggtgcgtccc
    11941 tgagtgcaac ggcccgtcgt ccgtacaccg tcggcgagcc ccgaggggag ggcgcatgac
    12001 acgcggcacc acaggcggca ggtccgtcgt gccggcccgc tcgccggggc ccgcggcagg
    12061 tcacgcggtc gtcgtcggag gcggactggc cggagtcacc gccgcgctcc agcttgccga
    12121 cgccggcatg cgggtgacgc tgctggaagg gcgcccgcgc ctgggcggcc tcgcgttctc
    12181 cttccgccgc ggcgagctca ccgtcgacaa cggccagcac gtctacctgc gctgctgcac
    12241 cgcctaccgg tggttcctcg accgggtcga gggcgccgga cttgccccgc tgcagagccg
    12301 cctcgacgta cccgtcctcg acgtcggccg gcccgccggg ccccggctcg ggcggctgcg
    12361 ccgcacggcg ctgcccgtac cgctgcacct ggccgcgagc ctggcggcgt atccgcatct
    12421 ctccctcgcc gagcgggcga gcgtggggcg tgccgctctg gcgctcaaga agctcgatcc
    12481 ggccgatccc gccctggacg gtgtggactt cgccacctgg ctgggccgcc acggacagtc
    12541 gccgcgcacc atcgaggcgc tgtgggacct cgtcggcgtc gcgacgctca acgcgaccgc
    12601 gcccgacgcc tccctgggcc tcgccgcgat ggtcttcaag accgggctgc tctccgaccc
    12661 cggcgccgcc gacatcggct gggcgcacgt accgctcggc gatctgcacg acacactcgc
    12721 ccgcaaggcg ctcgactccg cgggtgtacg gaccgcactg cgcacccggg tcagctccct
    12781 ctcccgttcg gtgagcgggg gctggtccgt cggcacggcg gccggggagc ggatcgaggc
    12841 cgacgccgtc gtgctcgccg taccgcagcg cgagacgcac gccgtgctgc ccgagggtgt
    12901 catcgacgac cccggccggc tgctggacat cggcaccgcg ccgatcctca acgtccatgt
    12961 cgtgtacgac cgcaaggtgc tgcgccggcc cttcttcgcc gcgctcggca gccccgtcca
    13021 gtgggtcttc gaccggacgg agtcctccgg gctgaggggc ggcggacagt acctcgccgt
    13081 ctcgcagtcg gcggcccgag gcgagatcga cgcgcctgtg gccgagctgc gcgcacgcta
    13141 tctgcccgag ctggaacggc tgttgcccgc cgcgcgcggc gcgggcgtac gcgacttctt
    13201 cgtcacccgg gagcggacag cgacgttcgc ccccaccccc ggcgtcggac ggctgcgccc
    13261 cggcgcccgt acgcacgcgc ccggcctgta cctggccggc gcgtggaccg ccaccggatg
    13321 gcccgcgacc atggagggcg ctgtgcgcag cggcatcacc gccgccggtg cggccctccg
    13381 cgaactcggc cgcgtacatg aacatccgtt gcaggaggcg gtatgagcac tggcatggaa
    13441 acaagaggag agcctgtgac cccggtgaac ccggtggaca acaccacggt ggacatcgcc
    13501 gcgctgctgg agcgcggccg caccctgtcc accccggtgc tgaaggccgc cgtgggccgg
    13561 ctcgcgccgc ccatggacac cgtcgcggcg taccacttcg ggtggatcga cgcccagggg
    13621 cggccggccg acggcgacgg cggcaaggcg gtgcgtccgg cgctcgcgct gctgtcggca
    13681 caggcggcgg gcgcggcggc cgaggtcggt gttcccggcg ccgtcgccgt cgaactcgta
    13741 cacaactttt cgctcctcca cgacgacctg atggacggcg acgagcagcg caggcaccgc
    13801 gacaccgtgt ggaaggtgca cggacccgcg caggcgatcc tcgtcggcga cgcgctcttc
    13861 gccctcgcca acgaggtgtt gctcgagctc ggcacggtcg aggcggggcg cgccacgcgc
    13921 cggctcacca ccgcgacccg gaagctcatc gacggtcagg cgcaggacat ctccttcgag
    13981 caccgcgagc gggtcaccgt cgaggagtgc ctggagatgg agggcaacaa gacgggcgcg
    14041 ctgctggcct gtgccgtgtc catcggcgcg gtgctcggcg gggcggacga ccgtacggcg
    14101 gacacgctgg aggcgtacgg ctaccacctc ggtctcgcct tccaggccgt cgacgacctg
    14161 ctcggcatct ggggcgaccc ggacgccacc ggcaagcaga cctggagcga cctgcgccag
    14221 cgcaagaagt ccctgcccgt cgtcgcggcg ctggcggccg gcggtccggc gtcggagcgg
    14281 ctcggcgagc tgctctccgc cgacgccaag agcaacgact tcgagagctt ctccgagcag
    14341 gagttcgcca ccagggcggc tctgatcgag gaggcgggcg gccgtgactg gacggcgcag
    14401 gaagctcgca ggcagcatgc cgtcgccatc gaggcgctgg acggcgtcga catgcccccg
    14461 caggtccgtg cgcagctcac cgcgctcgcg gacttcgtcg tcgtacgaaa gagatgatca
    14521 gcatccgcct catataactc gcaagtcgcc gtccggtgcc gggattcgcc gtaaaccccg
    14581 caccggacga cgtcggaccc cagctcagca gatgaccaac tgccacgaag gggaaaccat
    14641 gacagcgacg accgacggaa gccctggggc catgaagccc tgcgcggccg cggccagcga
    14701 atttaccgac aacaacacca ataccaccac cacagagatc acccgtcacg ggccggtcat
    14761 cgccggcgtt ctggacgccg cgcggcgggc cacggaccgc ggggtcgcgc atctgctcgc
    14821 acagcaggac gaccagggct ggtggaaagg tgacctcgaa accaatgtga ccatggacgc
    14881 cgaggacctg ctgctgcgtc agttcctggg catccaggac gagaagaccg tccgggccgc
    14941 cgcgctcttc atccgcggcg agcagcgggg cgacggcacc tgggccacct tctacggcgg
    15001 tcccggcgac ctctccacca ccatcgaggc gtacgtcgcc ctgcggctcg ccggtgacct
    15061 gccggacgct ccgcacatgg agcgcgccgc ggcctggatc agggcgcgcg gcggcatcgc
    15121 cgcgagccgc gtcttcaccc ggatctggct ggcgctgttc gggtggtgga agtgggacga
    15181 tctgcccgag ctgccacccg agctgatctt ccttccgtcg tggttcccgc tgaacatcta
    15241 cgacttcggc tgctgggcca ggcagaccat cgtgcctctg accgtggtct ccgcgaagcg
    15301 gcccgtgcgt cccgcgccgt tcgcgctcga cgagctgcac gccaacccac gcgtgccgaa
    15361 cccacgcaag aggctttcca cgcctaccag ttgggagggt gccttccagc ggctcgacaa
    15421 ggccctgcac gtctaccgca aggtcgcgcc ggccaggctg cgcggcgccg cgatgaagag
    15481 cgcggcgcgc tggatcgtcg agcggcagga gaacgacggc tgctggggcg ggatccagcc
    15541 acccgccgtg tactccctga tcgcgctcca cctgctcgga tacgacctgg accacccggt
    15601 gatgcgcgcc ggcctggagt cgctcgaccg gttcacggtg tggcgcgagg acggcgcccg
    15661 catgatcgag gcctgccagt cgccggtctg ggacacctgc ctcgccacca tcgcactcgc
    15721 cgacgcgggg gtacggcccg acgatccggc cctcgtcaag gccgccgact ggatgatgag
    15781 cgagcagatc gtacggcccg gggactgggc cgtacgccgc cccggagtcg agccgggcgg
    15841 ctgggcgttc gagttccaca acgacaacta ccccgacatc gacgacaccg ccgaagtcgt
    15901 cctggcactg cggcgcgtcg cgcacccgga ccgcgcgcgg acagaggcga ccgtcgaccg
    15961 cgccgtccgc tggaacctcg gcatgcagtc gaagaacggc gcctgggcgg ccttcgacgc
    16021 cgacaacacc agccctttcc ccaaccggct gcccttctgc gacttcggcg aggtcatcga
    16081 cccgccgtcc gccgacgtca ccgcgcacgt ggtggagatg ctggccgtcg aaggcaaggc
    16141 acacgacccg cgcacccggc gcggcatcga gtggctgctg gccgaacagg agccgagcgg
    16201 tgcctggttc ggccgctggg gcgtcaacta cgtatacgga acaggggcgg tcgtgccggc
    16261 actgatcgct gccgggctgc cggccgccca ccccgccgtc cgtcgcgccg tcggctggct
    16321 ggagtccgtc cagaacgacg acggcggctg gggcgaggac ctgcgttcgt accgtgaggc
    16381 cggctgggcc gggcgcggtg cttcgaccgc ttcgcagacc gcctgggcgc tgctcgccct
    16441 gctcgcggcg ggggagcggg acggccggtc cgtggagcgg ggcgtcgcct ggctggccgg
    16501 gacccagcgg gaggacggct cctgggacga gccgtacttc acgggcaccg gattcccgtg
    16561 ggacttctcc atcaactacc acctctaccg gcaggtcttc ccgctcaccg ccctcgggcg
    16621 gtacgtccac ggggagccca cctacccgga cctggccacc cgggaaggga cctgatggcc
    16681 cccatggacc cggccgaccg gaccgatccg gctgacgagc cgccgcggcc cgcgccgctg
    16741 ctgatcgcct gcgcgctcgg catcgagcag ttcgcgctgc gcagtggaca ccgcaaggag
    16801 gcgccggggc ccgtgaccgt actgcgtacg gggatgggcc ccaaggcggc ggcgacggcc
    16861 gtcaggcagg cgctcgccca cggcggtccg gccccggacg ccgccgtcat cgcatccggc
    16921 ttctgcgcgg ggctggtccc cggaatgcac cccggagacc tgatcgtcgc cgacgagacg
    16981 cgcggacccc acggcacttc ggcctgtacg ggcgtggagc tgctcgcgaa ggcgctggac
    17041 cgggtggtgc ccggacgcac cgtgcacacc ggcccgctgc tcggctccgc ccatgtcgtg
    17101 aggggacccg agcgggcccg gctggcggcc accggggcga tcgccgtgga catggagtcc
    17161 gccgcgacgc tcggcagcgc gctgcgggcc ggaccgcgtc cggttgcggc cgttcgggtg
    17221 gtcgtggacg ctccggagca cgagctcgta cgcattggaa cgcttcgcgg tggaatatcg
    17281 gcatttcgtg ttcttcgcgc agtgctgcca gccttttttg aatggcaccg ttcttcgctg
    17341 ctccccagga ggtgagctag atggccatgc cgctccgtca gaccatcagg gtcgggacgt
    17401 atctcgtaga acaaaagctc cgcaagcgag agaagttccc gctcatcgtc gagctcgaac
    17461 cgctctacgc ctgcaacctc gcgtgcgagg gctgcggcaa gatccagcac ccggcggggg
    17521 ttctgaagca gcgcatgccc gtggcgcagg ccgtgggagc ggtcctggaa tccggtgctc
    17581 cgatggtctc catcgcgggc ggcgagccgc tgatgcatcc tcagatcgac gagatcgtgc
    17641 ggcagctggt ggccaagagg aagtacgtat tcctctgcac caacgcgatg ctgctgcgca
    17701 agaagatcga gaagttcacg ccgtcgccgt acttcgcctt cgccgtgcac atcgacgggc
    17761 tgcgggagcg gcacgacgaa tcggtcgcga aggaaggcgt cttcgacgaa gcggtggagg
    17821 cgatcaagga ggccaagaag cgcggtttcc gggtcaccac caattccacc ttcttcaaca
    17881 ccgacacccc gcagacgatc atcgaggtgc tcaattacct caatgacgac ctggaggtgg
    17941 acgagatgat gatctcgccc gcctacgcgt acgagaaggc tcccgaccag gagcacttcc
    18001 tcggggtcga gcagacgcgg gagctgttca agaaggcgtt cgcgggtggc aaccggcggc
    18061 gctggcggct gaaccactcg ccgctcttcc tggacttcct ggagggcaag gcggacttcc
    18121 cgtgcacggc gtgggcgatc cccaactact ccctcttcgg gtggcagcgg ccctgctacc
    18181 tgatgagcga cgggtacgtc ccgacgtacc gggagctcat cgaggagacc gactggagca
    18241 agtacgggcg gggcaaggac ccgaggtgcg ccaactgcat ggcgcactgc ggctacgagc
    18301 cgacggccgt cctcgcgacc atgggctcgc tcaaggagtc cctgcgagcg gtccgggaga
    18361 cggtctcggg aaaccacggg tgacgtcatg acccttggtg agcctgtcgc actggggctc
    18421 cccgagctgc cggcccggcc cctggcggtg cgccgcgctt cgcggcgtat ccaggtcggg
    18481 tcggtggcgg tcggcgggga cgcgccggtc tcggtgcagt cgatgacgac gacgaggacg
    18541 tccgacgtcg gggcgacgct ccagcagatc gcggagctga cggcttcggg ctgccagatc
    18601 gtacgggtgg cgtgtcccac ccaggatgac gcggacgcgc tggcgaccat cgcgcgcaag
    18661 tcgcagatcc cggtgatcgc ggacatccac ttccagccga agtacgtctt cgccgccatc
    18721 gacgccgggt gcgcggcggt gcgggtgaat ccgggcaaca tcaagcagtt cgacgacaag
    18781 gtgaaggaga tcgccaaggc ggcctccgag acccgtacgc cgatccgcat cggcgtgaac
    18841 gccgggtcgc tggacgcgcg gctgctgcag aagtacggga aggcgacccc ggaggcgctg
    18901 gtcgagtcgg cgctgtggga ggcgtctctc ttcgaggagc acggtttcgg tgacatcaag
    18961 atctcggtca agcacaacga cccggtcgtg atggtcaacg cgtaccggca gcttgccgcc
    19021 cagtgcgact atccgctgca
//
