LOCUS       NZ_KE386846            22543 bp    DNA     linear   CON 22-APR-2024
DEFINITION  Streptomyces flavidovirens DSM 40150 G412DRAFT_scaffold00009.9,
            whole genome shotgun sequence.
ACCESSION   NZ_KE386846
VERSION     NZ_KE386846.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces flavidovirens DSM 40150
  ORGANISM  Streptomyces flavidovirens DSM 40150
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 265539)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces flavidovirens DSM 40150
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: DSM 40150, ATCC 19900
            finishing_strategy                :: Level 1: Standard Draft
            GOLD Stamp ID                     :: Gi11969
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site                    :: Soil
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-03-07
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000429085.1-RS_2024_04_22
            Annotation Date                   :: 04/22/2024 01:37:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,525
            CDSs (total)                      :: 6,452
            Genes (coding)                    :: 6,216
            CDSs (with protein)               :: 6,216
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 236
            CDSs (without protein)            :: 236
            Pseudo Genes (ambiguous residues) :: 0 of 236
            Pseudo Genes (frameshifted)       :: 106 of 236
            Pseudo Genes (incomplete)         :: 173 of 236
            Pseudo Genes (internal stop)      :: 25 of 236
            Pseudo Genes (multiple problems)  :: 59 of 236
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18314
            Orig. end                         :: 40857
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KE386846.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 1011953
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos   Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI
            Annotation by JGI
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22543
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22543
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22543
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12543](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12543
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    202..216
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
     gene            complement(217..720)
                     /locus_tag="G412_RS0130825"
     CDS             complement(217..720)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014175057.1"
                     /locus_tag="G412_RS0130825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_028815392.1"
                     /transl_table=11
                     /translation="MGMSVTISAATAQDAEQILKLQYLCYQSEAELYGDYRIEPLTQTL
                     DDLRAELGRGHALVARLGDEVVASVRAAVDEAGTARIAKLIVHPRMQRHGLGGRLLDAI
                     EEYVAGEPAAKRFQLFTGHRSEGNLRLYRSHGYAPVATEQVAPGFALVTLQKEPAPQAY
                     AASA"
     gene            complement(758..1303)
                     /locus_tag="G412_RS0130830"
     CDS             complement(758..1303)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970284.1"
                     /locus_tag="G412_RS0130830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_037650513.1"
                     /transl_table=11
                     /translation="MPAAPPTAASPSALFSSLRPLLAAEAVAEAAGGGVEPGDLEQAVW
                     LRLLELLDGSGPPPDPAGWLLHAVRTEASLARRATRRELPYPSPPAATTDTACPERAAL
                     SAERRRVLRAAVGRLPGRCRRLLDAMLSPADPTYREIAGELGMSQGSLGPMRSRCLGCL
                     RRMLAAEVAAPGQRGMER"
     gene            complement(1405..2556)
                     /locus_tag="G412_RS0130835"
     CDS             complement(1405..2556)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576452.1"
                     /locus_tag="G412_RS0130835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycerophosphodiester phosphodiesterase"
                     /protein_id="WP_028815394.1"
                     /transl_table=11
                     /translation="MTQGGQAKPGRRSVLGAAVLGAGGVTLGLPGTAGAAAGKGHGSYR
                     DLPVPTVVAHRGASGYRPEHTIGSYQLALDMGAHVIEQDLVPTKDGHLVCRHENDITGT
                     TDVAAHPEFASRKTTKSVDGVSLTGWFTEDFTLAELKTLRAKERIPGTRQENTLYDGRW
                     TIPTFEEVLRWAEHEGRARGRRIWLHVETKHPTYFRGLGLGLEEPLADLLRKYGRHKKN
                     APNFLQSFEPSSMRRMAELVAAPRVVLLDAADTRPWDFVQAGDRRTVADLVKPEGLKWI
                     AGFAQGIGPWLDLIIPKDAAGKLGRPTTLVRDAHAQGLVVHPYTMRNENTFLPADFRRG
                     TDPAAYGDAFGALKLYFEQGIDGIFSDNPDTALLAAADFARHR"
     gene            2808..3479
                     /locus_tag="G412_RS0130840"
     CDS             2808..3479
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1141: acyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006123280.1"
                     /locus_tag="G412_RS0130840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_028815395.1"
                     /transl_table=11
                     /translation="MSRLALIKAVLGPILRLMFRPQVEGAQNIPGTGPVILAGNHLTFI
                     DSMIMPVCCDRQVYYIGKDEYVTGKGLKGRLMAWFFTSCGMIPVDRDGGRGGVAALMTG
                     RRVLEEGKIFSIYPEGTRSPDGRLYRGRTGIARLTLMTGAPVVPFAMIGTDKLQPGGAG
                     LPRPGKVTVRFGEPMEFSRYEGMDRDRYVLRAVTDSVMAEVMRLSGQEYVDMYATKAKA
                     A"
     gene            complement(3552..5102)
                     /locus_tag="G412_RS0130845"
     CDS             complement(3552..5102)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884913.1"
                     /locus_tag="G412_RS0130845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_028815396.1"
                     /transl_table=11
                     /translation="MTSSGRHPMAREAIHHPGRWLALGVLVLAVLLVAVDATVLGLATP
                     FLSEDLQPSGTQLLWIGDVYSFIIAGLLVSMGSLGDRIGRKKLLLTGAVAFGAVSVLNA
                     YATSPEMMILARALLGVAGATLMPSTLALIRNIFHDAEERSFAIGVWGAAASAGAAVGP
                     VVGGFLLENFWWGSVFLINVPVMLILVLVGIKLLPESKNPAPGPWDLLSVGLSLVGMVC
                     VVYAVKEAAAHGFRWDIGLTAVAGVAALVWFVRRQLTLPSPLLDMRLFHHRGFSGAVLA
                     DLLTILGLSGLVFFLSQFLQLVQERSPLESGLIELPAAAGAVAAGLVAGYVARRVSVRS
                     AVTGGLVALGIGLASCTVVTADTGVVMLVSAMIVGGIGAGLAFTVTADVILSSVPKEQA
                     GAASAVSETAYELGAALGIALLGSIVTGIYRGFTVPAGTPGDVADAAHDSLGGAVESSA
                     ALPPEQAAALISMAQDAFTDGFQAAAWVGSVVLFATAAAAWFMLRGQKLAVGIVADEP"
     gene            complement(5099..5650)
                     /locus_tag="G412_RS0130850"
     CDS             complement(5099..5650)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070182.1"
                     /locus_tag="G412_RS0130850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_028815397.1"
                     /transl_table=11
                     /translation="MTVDREQVLRTAAALLSRKATATMDEVAKSAGIGRATLHRHFAGR
                     DALVKALEELGIREFEAALDTARLDEGTAEEGLRRLIAEIEPAAGLLAFLVTENQLFEG
                     AHVNEGWGRLDARVSAHFRRGQQQGEFRIDLTPAWLTEALYGLIGTGAWAVQDGRVAAK
                     DFQYMIVELLLGGARRNVEQ"
     gene            complement(5726..6697)
                     /locus_tag="G412_RS0130855"
     CDS             complement(5726..6697)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103826.1"
                     /locus_tag="G412_RS0130855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_028815398.1"
                     /transl_table=11
                     /translation="MPFARLAAVTTATAHFGLGLAALGRPAYITPGRDRDLPGGRSPDA
                     LRKRAHELLDAAYAQGVRYFDAARSYGRAEEFLAQWLRARPEIQDVVIGSKWGYTYTAD
                     WRSDAEVHEVKDHSVEAFERQRAETDALLGERLDLYQIHSVTPDSPALTDPALHALLAE
                     FAAGGVTVGISTSGPAQADAIRAALAVTVDGEPLFRTVQATYNLLETSAAQALAEAHDA
                     GLTVIVKEALANGRLAGSAAPPALRAVAAETGSTCDAVALAAILRLPWAGVVLSGAATV
                     LQLSANLHAAVVDLDEGQLARLAELPEEPAAYWKHRSQLPWS"
     gene            complement(6764..8191)
                     /gene="argH"
                     /locus_tag="G412_RS0130860"
     CDS             complement(6764..8191)
                     /EC_number="4.3.2.1"
                     /GO_function="GO:0004056 - argininosuccinate lyase activity
                     [Evidence IEA]"
                     /GO_process="GO:0042450 - arginine biosynthetic process via
                     ornithine [Evidence IEA]"
                     /codon_start=1
                     /gene="argH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019884915.1"
                     /locus_tag="G412_RS0130860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="argininosuccinate lyase"
                     /protein_id="WP_028815399.1"
                     /transl_table=11
                     /translation="MSSNNGDVRLWGGRFADGPAEALAKLSASVHFDWRLAPYDIAGSR
                     AHARVLHKAGLLTADELERMQAGLDQLEADVANGSFVGTIADEDVHTALERGLLERLGP
                     DLGGKLRAGRSRNDQVATLFRMYLRDHARVIGGLLAELQDALVGLAEAHADVAMPGRTH
                     LQHAQPVLFAHHVLAHAQSLSRDAERLRQWDERTAVSPYGSGALAGSSLGLDPEAVAAD
                     LGFERGSSGNSIDGTASRDFVAEFAFITAMIGVNLSRIAEEIIIWNTKEFSFVTLHDAF
                     STGSSIMPQKKNPDIAELARGKSGRLIGNLTGLMATLKALPLAYNRDLQEDKEPVFDSC
                     DTLEVLLPAFTGMLATLTVNRERMEELAPAGFSLATDIAEWLVRQGVPFRVAHEVAGEC
                     VKECEQQGIELDQLTDEQFAKISPHLTPEVRTVLNVAGALASRNGRGGTAPSAVAVQLD
                     EVKADLAIQHAWATAKN"
     gene            complement(8275..9468)
                     /locus_tag="G412_RS0130865"
     CDS             complement(8275..9468)
                     /EC_number="6.3.4.5"
                     /GO_function="GO:0004055 - argininosuccinate synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1291: argininosuccinate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607538.1"
                     /locus_tag="G412_RS0130865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="argininosuccinate synthase"
                     /protein_id="WP_028815400.1"
                     /transl_table=11
                     /translation="MTERVVLAYSGGLDTSVAIGWIAEETGAEVIAVAVDVGQGGEDLD
                     VIRKRALACGAVEAEVADAKDEFAEEYCLPAIKANALYMDRYPLVSALSRPTIVKHLVA
                     AANKHGASIVAHGCTGKGNDQVRFEAGISALGPDLKCIAPVRDYAMTRDKAIAFCEEKN
                     LPIATTKKSPYSIDQNVFGRAVETGFLEDIWNAPIEDIYEYTSNPALPREADEVVISFK
                     EGVPVAIDGKPVTVLQAIQQLNERAGAQGIGRIDMVEDRLVGIKSREVYEAPGAIALIT
                     AHQELENVTVERELARYKRQVEQRWGEMVYDGLWFSPLKRALDGFINEANQHVTGDIRM
                     TLHGGRAVVTGRKSDESLYDFNLATYDSGDTFDQSKAQGFIEIFGLSSKIAAKRDLA"
     misc_feature    9499..9512
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.33"
                     /tool="antismash"
     gene            10001..11857
                     /locus_tag="G412_RS0130870"
     CDS             10001..11857
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990135.1"
                     /locus_tag="G412_RS0130870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_028815401.1"
                     /sec_met_domain="Asn_synthase (E-value: 5.9e-36, bitscore:
                     118.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGLTGLAAVPSWFVVLPDCAAAGPLARALRGYADVTVSHPSGQP
                     WVLGRWAVDEMAAAEAGDSKVAVLGQHASADRRRVSRSAERVRTPGDVDALAAELTGSS
                     HLIASVAGKVRVQGTVTGLRRVFSAEINGVTAASDRADVLALLLGSGMDERRLAVHLLV
                     PPVLHPLSDKPVWRDVTFLPTDRYLLLDESGRARQIRWWTPPEPELPLAQGAQRLRAAL
                     TAAVDARTGGRDPVGCDLSGLDSTSVCSLAARRSKVVACTAASPDPLDDDVLWATRTAA
                     ALDGGVEHHVIPSDEMPLIYHGLLDVDELFDEPCGSIADHARWLTIAGRAAAHGCRLHL
                     TGFGGDELLASSTSHLLTLLRTRPAVALRQLNVLATKHGWSRKQLLRELADRRPYDRWL
                     LGAADRLTTPSAQDGVSLGWGSPPSLPPWATPEAVGAVRELIRAEAPTAEPLAGRQGQH
                     FELEGIQYAAHPVRHIARLADRAGITLAAPYFDDRVLEASLAVRPEEKGTPWEYKPLIL
                     AAMRGIIPPASLTRQTKSGGICDLNVALRTNRADLLALWDDSRLGRLGLIDAAELRGIC
                     TRPLDPNHPHDLHGGLYQSVACEIWLRTWERAAAQPTAGAMP"
     aSDomain        11854..12108
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_G412_RS0130875_Stand_Alone_Lasso_RRE.
                     1"
                     /evalue="6.00E-28"
                     /identifier="RREFam002.1"
                     /label="G412_RS0130875"
                     /locus_tag="G412_RS0130875"
                     /protein_end="85"
                     /protein_start="0"
                     /score="87.7"
                     /tool="antismash"
                     /translation="MTLKLRTGVSCADTDYGIALLDEDSGEYWELNPTGAQVLRLLLRG
                     GTSEQAVRDLTDTCDVDAESARDDVRGLVEALDSSGLVER"
     gene            11854..12111
                     /locus_tag="G412_RS0130875"
     CDS             11854..12111
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655083.1"
                     /locus_tag="G412_RS0130875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_028815402.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5.1e-27,
                     bitscore: 87.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.5e-15, bitscore: 51.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLKLRTGVSCADTDYGIALLDEDSGEYWELNPTGAQVLRLLLRG
                     GTSEQAVRDLTDTCDVDAESARDDVRGLVEALDSSGLVER"
     gene            12127..12543
                     /locus_tag="G412_RS0130880"
     CDS             12127..12543
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655082.1"
                     /locus_tag="G412_RS0130880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_028815403.1"
                     /sec_met_domain="PF13471 (E-value: 5.3e-27, bitscore: 88.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFPQALSHEPRAVPPARRAEVRLVVGLARLLARHPPRRIRAVLR
                     RVSRGARPARYDEALAARETVVAVSLACAAPEGCLPRSLATALLCRLHGRWPVWCVGAR
                     RVAPFAAHAWVEAAGVPVGEDAPPDYFRAFFTVP"
     gene            12540..14336
                     /locus_tag="G412_RS0130885"
     CDS             12540..14336
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042082.1"
                     /locus_tag="G412_RS0130885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_037650518.1"
                     /transl_table=11
                     /translation="MSGTGGDGVPGGGHLTAPREVLRVLRGHRRWIAGAVTLTLIASAL
                     GLAQPLVVRRVIDSSGAGTAVAGSVVLLVALFVAQALVEAVAGYVLARTGEGVVLGVRL
                     NLIDHLLRLPMRTYDRHRIGDLISRAGTDSTALRLLIAQGFTDAVTGSIGLAGVVALMI
                     WLDWALFLVVIAMIAFGALVVASVLRGIARASLHAQQATGSMTAELERALGAIRTVRAS
                     RAERREADRIGAQARSAFSAGVRVGKLDAVVTPAIDLTLHGSFLVVLLIGGVRVAGQGG
                     SVADLAAFLLYMLYLVGPVGAVFQAVSTMQQGAGALRRIAEILDLPQEPDSGRRYDVTS
                     PATEVTRPPVLEFRDVWFGYDPRHPVLRGVSFEVPPRGHVALIGSSGVGKSTVFALAER
                     FYDPDEGLVLFEGRDVRTLSRAQHRARIGLVEQHAPVMYGTLRENLLYAAPEAGAGELD
                     RVVELAQLTELASRLPRGLDTDAGEHGMALSGGERMRIAIARSLLTRPSLLLLDEPTAH
                     LDAVNEAALRRSIRRTSGECALLVIAHRFSTIHAADLIVVLDAGEIVATGSHEELLDTS
                     DHYRSLCRAQQVEGPEGAGRRP"
     gene            14464..15822
                     /locus_tag="G412_RS0130890"
     CDS             14464..15822
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004921857.1"
                     /locus_tag="G412_RS0130890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_028815405.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.8e-44, bitscore:
                     146.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPKILVVGAGFAGVQCLQRLERKLAPREAELVLVSPSDYQLYL
                     PLLPHVAAGVLTPQSVAVSLRRRLRRTRICPGGAIGIDGRAKVCVIRKITGEVIAESYD
                     QLVLVAGSTTRTFDIPGLRDHGRGMKSLAEAAHLRDHVIAQLDIAAATTDQAEREARLR
                     FVVVGGGYAGTETAACLQRLTSAAVERYPNLDRAQIKWHLVDVAPRLLPELGEKLGEKA
                     MAMLRYRGIEFSLGTSVASVDATSVRLTDGRTLPSHTLIWTAGVAASPLVATLGAETVR
                     GRLAATPQLTVPGFDGLFAAGDAAAVPDVAKGGDAMCPPTAQHAQRQGKVLADNIVARL
                     RGMPLKPYVHKDLGLVVDLGGRDAVSKPLGVELHGLPAQAVARGYHLLALPTMTARTRV
                     MTNWTLNAVAGDDFVRTDFQARRAGTLQDFENTSVYLTPEQVREHSGQPAARH"
     misc_feature    complement(15852..15868)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.04"
                     /tool="antismash"
     misc_feature    complement(15876..15889)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.67"
                     /tool="antismash"
     misc_feature    15877..15890
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.76"
                     /tool="antismash"
     misc_feature    complement(15877..15892)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.75"
                     /tool="antismash"
     gene            15890..16471
                     /locus_tag="G412_RS0130895"
     CDS             15890..16471
                     /EC_number="1.-.-.-"
                     /EC_number="1.4.3.5"
                     /GO_function="GO:0004733 - pyridoxamine phosphate oxidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017945496.1"
                     /locus_tag="G412_RS0130895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_028815406.1"
                     /transl_table=11
                     /translation="MGKLYERIDGRIRTFIEDQPVFFTATAPLTADGHVNVSPKGRAGT
                     LVVLDEMTLAYLDFGGSTAETVAHIRENGRVTLMWCAFSGPPKVLRVHGQGEAVFRDDS
                     RWPGLITRFKDVDGPSARAIVVVHARRISDSCGFAVPFMEYQEERTQHAEHFARKTDEE
                     FAAYCEKKEYLGKSLDGLPALPLPLPARAD"
     misc_feature    complement(15939..15954)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            complement(16490..17032)
                     /locus_tag="G412_RS0130900"
     CDS             complement(16490..17032)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019764598.1"
                     /locus_tag="G412_RS0130900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="arginine repressor"
                     /protein_id="WP_028815407.1"
                     /transl_table=11
                     /translation="MTEAQAQDHEHGGPAVPQTRTARHRRIVDILNRQPVRSQSQLAKL
                     LADDGLSVTQATLSRDLDELGAVKIRNTGGELIYAVPSEGGFRTPHAPLGESAKEERMR
                     RLSGELLISAEASANLVVLRTPPGAAQFLASAIDQAELNAVLGTIAGDDTLLLISRDPA
                     GGQALADHLLRLAQNDR"
     gene            complement(17038..18195)
                     /locus_tag="G412_RS0130905"
     CDS             complement(17038..18195)
                     /EC_number="2.6.1.11"
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (12-324). E-value: 1.1e-97.
                     Score: 319.0. Matches aSDomain:
                     nrpspksdomains_G412_RS0130905_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044899.1"
                     /locus_tag="G412_RS0130905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetylornithine transaminase"
                     /protein_id="WP_051338739.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.8e-106, bitscore:
                     348.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDNYGTPKLSLVRGRGAKVWDADGKEYADFVGGIAVNALGHAHP
                     AIVEAVSRQVASLGHVSNLYVAEPPVALAERLIQLSGRPGRVFFSNSGAEANEAAFKIG
                     RLTGRTHMVATEGGFHGRTMGALALTGQEAKRTPFLPLPGDVTHVPFGDVDALRAAVTT
                     DTALLIIEPIQGEFGVVVPPEDYLRAAREITRATGTLLVLDEVQTGIGRTGHWFEYQGH
                     DAVEPDVVTLAKGLGGGLPIGATLAFGAAADLLKPGQHGTTFGGNPVACAAGLAVLDTI
                     AADGLLDHVKRMGEKLRDGIESLGHPLVSHVRGAGLLLGIVLTESLAPQVQQAAQDAGL
                     LVNAPAPDVVRLMPAYLIGDEEVETFLRALPGVLDTAHGDRRSGE"
     aSDomain        complement(17224..18159)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G412_RS0130905_Aminotran_3.1"
                     /evalue="1.10E-97"
                     /label="G412_RS0130905_Aminotran_3.1"
                     /locus_tag="G412_RS0130905"
                     /protein_end="324"
                     /protein_start="12"
                     /score="319.0"
                     /tool="antismash"
                     /translation="VRGRGAKVWDADGKEYADFVGGIAVNALGHAHPAIVEAVSRQVAS
                     LGHVSNLYVAEPPVALAERLIQLSGRPGRVFFSNSGAEANEAAFKIGRLTGRTHMVATE
                     GGFHGRTMGALALTGQEAKRTPFLPLPGDVTHVPFGDVDALRAAVTTDTALLIIEPIQG
                     EFGVVVPPEDYLRAAREITRATGTLLVLDEVQTGIGRTGHWFEYQGHDAVEPDVVTLAK
                     GLGGGLPIGATLAFGAAADLLKPGQHGTTFGGNPVACAAGLAVLDTIAADGLLDHVKRM
                     GEKLRDGIESLGHPLVSHVRGAGLLLGIVLT"
     gene            complement(18234..19142)
                     /gene="argB"
                     /locus_tag="G412_RS0130910"
     CDS             complement(18234..19142)
                     /EC_number="2.7.2.8"
                     /GO_function="GO:0003991 - acetylglutamate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1174: acetylglutamate kinase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947121.1"
                     /locus_tag="G412_RS0130910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acetylglutamate kinase"
                     /protein_id="WP_028815409.1"
                     /transl_table=11
                     /translation="MSTRKHTALPKAQILVEALPWLTRHHGRTVVIKFGGNAMIDEDLK
                     AAFAQDVVFLRHAGLKPVVVHGGGPQISAQLDRHGLVSEFKAGLRVTTPEAMDVVRMVL
                     AGQVQRELVGLLNQHGPLAVGMTGEDAHTITATQHYPRIDGESVDIGRVGEITAIDTGA
                     IQALLDDGRIPVVSSIARSADDHHVFNVNADTAAAALAAALGAETLMVLTDVEGLYEDW
                     PHSDEVISRLTAKELERLLPELSSGMVPKMEGCLHAVRNGVNTARVIDGRVQHSILLEI
                     FTDEGIGTMVVPDQHEGGTTK"
     gene            complement(19139..20293)
                     /gene="argJ"
                     /locus_tag="G412_RS0130915"
     CDS             complement(19139..20293)
                     /EC_number="2.3.1.1"
                     /EC_number="2.3.1.35"
                     /GO_function="GO:0004358 - glutamate N-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006526 - arginine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1220: bifunctional ornithine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325166.1"
                     /locus_tag="G412_RS0130915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional glutamate
                     N-acetyltransferase/amino-acid acetyltransferase ArgJ"
                     /protein_id="WP_028815410.1"
                     /transl_table=11
                     /translation="MSVTAPKGFTAAGIAAGIKDSGGPDLALVVNNGPRLAAAGVFTTN
                     RVKAAPVLWSEQVVKGGQISAVVLNSGGANACTGPKGFQDAHATAEKAAEVLKGHSAGE
                     IAVASTGLIGITLPMGKLLPGIEKAATELSAHGGEKAAIAIKTTDTVHKTAVAGGDGWT
                     VGGMAKGAGMLAPGLATMLVVLTTDADLEAGVLDKALRDATRVTFDRVDSDGCMSTNDT
                     VLLLASGASEVTPGYDEFAAAVRTVCDDLARQLIGDAEGASKDIRIEVINAATEDDAVE
                     VGRSIARNNLLKCAIHGEDPNWGRVLSAIGTTKAAFDPDRLNVAINGVWVCKNGSVGED
                     RDLVDMRYREVRITADLASGTESAVIWANDLTADYVHENSAYSS"
     gene            complement(20382..21410)
                     /gene="argC"
                     /locus_tag="G412_RS0130925"
     CDS             complement(20382..21410)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019526146.1"
                     /locus_tag="G412_RS0130925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_028815411.1"
                     /transl_table=11
                     /translation="MAVRAAVAGASGYAGGELLRLLLAHPGVEIGALTGHSNAGQRLGS
                     LQPHLLPLAGRVLEPTTAEVLAGHDVVFLALPHGQSAAVAEQLGDEVLVVDMGADFRLQ
                     NAADWDQFYGSPHAGTWPYGLPELPGARAALEGSKRVAVPGCYPTAVSLALFPAYAAQL
                     AESDAVIVAATGTSGAGKALKPHLLGSEVMGSMSPYGVGGGHRHTPEMIQNLSAAAGER
                     ITVSFTPTLAPMSRGILATCSAKAKPGVTAAGVRDAYEKAYADEPFVHLLPEGQWPATA
                     SVYGSNAVQIQVAYDEAAGRVIAISAIDNLTKGTAGGAVQSMNIALGLPEDTGLSTTGV
                     AP"
     misc_feature    21414..21428
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     misc_feature    complement(21572..21587)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            21598..22122
                     /locus_tag="G412_RS40000"
     CDS             21598..22122
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016300.4"
                     /locus_tag="G412_RS40000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SIMPL domain-containing protein"
                     /protein_id="WP_157839219.1"
                     /transl_table=11
                     /translation="MPTATTCVTRSLVTATLAVGLLAGGTASAGAASGGDRTVPATEVA
                     RPALACKTVLATVVVESVKRTASEAMNHNTAVTRRVLETLEANGVAPRDAGTLRLSLTP
                     VLEPDGSGGSVVTGYRVRRTLAVTIRAGDRATAILDKAVAAAGGAARVTSVSCAPSDPA
                     GRQPSRVNTSA"
     gene            22184..22348
                     /locus_tag="G412_RS40005"
     CDS             22184..22348
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G412_RS40005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_157839220.1"
                     /transl_table=11
                     /translation="MNEHELASRGPVRPVRDHRTAERVIKAILIVAAVVAAIVVPFMCL
                     VIATYAMAD"
ORIGIN
        1 gccccttccc gaactggggc tccgccccag accccgctcc tcaaacgccg gagaggctgg
       61 agaattgccg caagcggcaa catccagccc acccccgcat atccagcccg tccggcgttt
      121 gaggacacgc ccggagggcg tccggggtct gggggcttgc ccccagttcg ggaaggggcg
      181 gggtggggaa caagccccgc agggccgacc cgccccctac gcgctcgccg cgtacgcctg
      241 gggtgccggt tccttctgga gggtcaccag cgcgaagccg ggggcgacct gttccgtggc
      301 gaccggggcg taaccgtggc tgcggtacag gcgcaggttg ccctcgctgc ggtgaccggt
      361 gaagagctgg aagcgcttgg ccgccggctc cccggcgacg tactcctcga tcgcgtcgag
      421 cagccgcccg ccgagcccgt gccgctgcat ccggggatgg acgatgagct tggcgatccg
      481 cgcggtcccc gcctcgtcga ccgccgcgcg cacggacgcg accacctcgt cgccgagccg
      541 cgccaccagc gcgtggccgc gcccgagttc ggcccgcagg tcgtcgaggg tctgggtgag
      601 cggctcgatg cggtagtcgc cgtacagctc ggcctcgctc tggtagcaca ggtactgcaa
      661 cttgaggatc tgctcggcat cctgcgccgt tgccgctgag atggtcacgc tcatgcccat
      721 gtgtgcatgc ctcccgctcg cctgatacgc cggttgctta tcgctccatt cccctttgcc
      781 caggagctgc aacctccgcc gcgagcattc tgcgcaggca tcccaggcaa cgggaacgca
      841 tgggccccaa actgccttgt gacattccca actcccctgc gatttcccgg tacgtggggt
      901 ccgccggcga cagcatcgcg tccagcagcc gccggcaccg gccgggcagc ctgcccaccg
      961 ccgcccgcag cacgcggcgc cgctcggcac tcagcgcggc gcgttccggg caggcggtgt
     1021 cggttgtggc ggccggcggg gaggggtacg gcagttcgcg ccgcgtcgcg cgccgggcca
     1081 ggctcgcctc ggtccgtacg gcgtgcagca gccagcccgc cgggtcgggc ggcgggcccg
     1141 acccgtcgag gagttcgagg agccgcagcc atacggcctg ttccaggtcg ccgggctcga
     1201 ctcccccgcc cgcggcctcc gccacggctt cggcggcgag cagcgggcgc agcgagctga
     1261 acagggcgga cggcgacgcg gccgtgggcg gggcggcagg catggggagg gtcatgccag
     1321 gcgggacgtg gcgccggcgg ccggcggttg ccgcgcggca ccactgtcac ccgtccgtgg
     1381 tcaccggccc gcaccaccag gcggtcagcg gtggcgcgcg aagtccgccg ccgccagcag
     1441 tgccgtgtcc ggattgtcgg agaagatccc gtcgatgccc tgctcgaagt agagcttcaa
     1501 ggcgccgaag gcgtcgccgt acgccgccgg atcggtgccg cgcctgaagt cggcgggcag
     1561 gaaggtgttc tcgttgcgca tcgtgtaggg gtgaacgacc aggccctgcg cgtgcgcgtc
     1621 ccgtaccagc gtcgtcggcc tgcccagctt gcccgccgcg tccttgggga tgatcaggtc
     1681 gagccagggg ccgatgccct gggcgaagcc ggcgatccac ttcaggccct cgggcttgac
     1741 caggtcggcg acggtacgcc ggtcacccgc ctggacgaag tcccagggcc gagtgtccgc
     1801 ggcgtccagc aggacgacac gcggcgcggc gaccagttcg gccatccgcc gcatgctgct
     1861 gggctcgaag gactggagga agttcggcgc gttcttcttg tggcggccgt acttgcgcag
     1921 caggtcggcg aggggctctt ccaggccgag gccgagtcct cggaagtacg tggggtgctt
     1981 ggtctcgacg tggagccaga tccgccggcc gcgcgccctt ccctcgtgct cggcccagcg
     2041 cagtacctct tcgaaggtgg ggatcgtcca ccggccgtcg tacagcgtgt tctcctgccg
     2101 ggtgcccggg atccgctcct tggcgcgcag cgtcttgagc tcggcgagcg tgaagtcctc
     2161 ggtgaaccag ccggtcagag agacgccgtc gacggacttg gtcgtcttgc gggaggcgaa
     2221 ctcggggtgc gccgcgacgt ccgtggtgcc ggtgatgtcg ttctcgtggc ggcagacgag
     2281 gtgcccgtcc ttggtcggca ccaggtcctg ctcgatgaca tgcgcgccca tgtccagggc
     2341 aagctggtac gagccgatgg tgtgctcggg gcggtagccg ctggctcccc ggtgcgcgac
     2401 gacggtcggt acgggcaggt cacggtacga gccgtggccc ttgcccgcgg cggcgcccgc
     2461 cgtgcccggc agcccgaggg tgacgccgcc cgcgccgagc acggccgcgc cgagaacgct
     2521 gcgccgcccc ggctttgcct gtccgccctg tgtcatgaac gctcctctgt gatgtcgcat
     2581 gtttcccgcg aagtttcccg ctaaagcgaa ggcccgatcg taggtgccta cgtcttacac
     2641 ggaggagact ctggacggaa cggggtggaa acacacgtca acactgcgta tcgatgtgat
     2701 gaacccgatg tgcggtcggc cggacaccgc gagtatcgtc ctcacctgca cagactcatc
     2761 cagacccggc cgccacgccc cactcggcca cgacaccgga ggaaccgttg tcccgtctcg
     2821 cgctcatcaa ggcagtgctc ggaccgatcc tgcgcctgat gttccgccca caggtggagg
     2881 gcgcccagaa cattcccggt accggtccgg tcatcctggc gggcaaccat ctgacgttca
     2941 tcgactcgat gatcatgccg gtctgctgcg accggcaggt ctactacatc ggcaaggacg
     3001 agtacgtcac cggcaagggg ctcaagggcc ggctgatggc ctggttcttc acgagctgcg
     3061 gcatgatccc ggtggaccgg gacggcgggc gcggcggtgt cgcggcgctg atgaccggcc
     3121 gccgggtgct cgaagagggc aagatcttct cgatctaccc ggagggcacc cgctcccccg
     3181 acggccgcct gtaccgcggc cgtacgggca tcgcccgcct cacgctgatg accggcgccc
     3241 cggtggtgcc gttcgcgatg atcggtacgg acaagctcca gccgggcggc gccggcctgc
     3301 cgcgtccggg caaggtgacg gtgcgcttcg gtgagccgat ggagttctcc cgctacgagg
     3361 gcatggaccg cgaccggtac gtgctgcggg cggtgacgga ctccgtgatg gcggaggtca
     3421 tgcggctgtc cggccaggag tacgtggaca tgtacgcgac caaggcgaag gctgcctgag
     3481 gcgacggggg cgtaacgcgg aggggccgtg ccaccgacgg gtggcacggc ccctccgccg
     3541 tacgccgtcc ctcagggctc gtccgcgacg atgcccaccg ccagcttctg gccccgcagc
     3601 atgaaccatg cggcggccgc cgtcgcgaac agcaccaccg agcccaccca cgccgccgcc
     3661 tggaagccgt cggtgaacgc gtcctgcgcc atggagatca gtgcggcggc ctgttcgggc
     3721 gggagcgccg ccgacgactc cacggccccg ccgagcgagt cgtgcgccgc gtccgccaca
     3781 tcgccggggg tgcccgcggg caccgtgaag ccgcggtaga tgccggtcac gatcgagccg
     3841 agcagtgcga taccgagcgc cgcgcccagt tcgtacgccg tctcggatac ggccgacgcg
     3901 gctcccgcct gctccttggg gacgctggac aggatgacgt ccgccgtcac ggtgaaggcc
     3961 agccccgccc cgatgccgcc gacgatcatg gctgacacca gcatcaccac gccggtgtcc
     4021 gccgtgacca cggtgcagct cgccagcccg atcccgagcg ccaccaggcc gccggtcacc
     4081 gcactgcgga ccgagaccct gcgcgccacg tagcccgcca ccagacccgc ggcgaccgcg
     4141 ccggccgcgg cgggcagttc gatgaggccc gactccagag gcgagcgctc ctggacgagt
     4201 tgcaggaact gcgagaggaa gaagaccagg ccggacaggc ccaggatggt cagcaggtcg
     4261 gcgaggaccg cgccggagaa cccgcggtgg tggaacaggc gcatgtcgag cagcggcgac
     4321 ggaagcgtga gctgacgccg tacgaaccag acgagcgccg ccacaccggc caccgccgtg
     4381 agtccgatgt cccagcggaa gccgtgcgcc gccgcctcct tgacggcgta cacgacacag
     4441 accatgccga cgagcgagag tccgacgctg agcaggtccc acgggccggg ggccgggttc
     4501 ttggactcgg gcagcagctt gatgccgacg aggaccagga tcagcatcac gggcacgttg
     4561 atgaggaaga ccgagcccca ccagaagttc tccaggagaa agccgccgac gaccgggccg
     4621 acggccgcgc ccgccgaggc cgcggcgccc cagacgccga tggcgaagct gcgttcctcg
     4681 gcgtcgtgga agatgttgcg gatcagcgcg agcgtggacg gcatcagcgt cgcaccggcc
     4741 acaccgagca gggcgcgggc gaggatcatc atttcggggc tggtggcgta cgcgttgagc
     4801 acggagaccg cgccgaacgc gacggcgccg gtcagcagca gcttcttgcg gccgatccgg
     4861 tcgccgaggc tgcccatcga tacgagaagt ccggcgatga tgaacgagta gacgtcgccg
     4921 atccacagga gctgggtgcc ggagggctgg aggtcctcgc tgaggaaggg tgtcgcgagg
     4981 ccgagtacgg tcgcgtcgac ggcgaccagg agcacggcga ggacgagtac gccgagggcc
     5041 agccagcggc cggggtggtg gatggcctcc cgcgccatcg ggtgccggcc gctactggtc
     5101 attgctccac gttccgacgt gctccgccga gcagcaactc gacgatcatg tactggaagt
     5161 ccttggccgc cacccggccg tcctggacgg cccacgctcc ggtgccgatg agcccgtaca
     5221 gggcctcggt cagccaggcc ggggtgaggt cgatccggaa ctcgccctgc tgctggccgc
     5281 gccggaaatg cgcggagacg cgcgcgtcca gacggcccca tccctcgttg acgtgggcgc
     5341 cctcgaagag ctggttctcg gtgacgagga aggcgagcag accggcggcg ggctcgatct
     5401 ccgcgatcag gcggcgcagt ccttcctcgg cggtcccctc gtcgagccgg gcggtgtcga
     5461 gcgccgcctc gaactcgcgg attccgagtt cttcgagcgc cttgacgagg gcgtcacgcc
     5521 cggcgaagtg gcgatgcagg gtggcccggc cgatgccggc cgatttggcg acctcgtcca
     5581 tggtcgcggt cgccttgcgg gagaggaggg cggccgcggt gcggagcacc tgctcgcgat
     5641 cgactgtcat gagacaacca taacccgaat gagacataaa tgtcccgaaa tcccggatcg
     5701 gcttctcagc tcagctcagc tcagctcagc tccagggcag ttgtgagcgg tgcttccagt
     5761 acgccgccgg ctcctccggc agctccgcga ggcgagccag ctgcccctcg tcgagatcca
     5821 ccaccgcggc gtgcaggttc gccgacaact ggagcacggt cgcggcgccc gacaggacga
     5881 cacccgccca cggcagccgc aggatcgccg ccagagcgac cgcgtcgcag gtggagccgg
     5941 tctccgcggc gaccgctcgc agggcgggcg gggcggcgga accggcgagc cggccgttcg
     6001 ccagggcttc cttcacgatc acggtcaggc ccgcgtcgtg cgcctcggcc agcgcttgcg
     6061 ccgccgaggt ctccagcagg ttgtacgtcg cctggaccgt acggaacagc ggctcgccgt
     6121 ccaccgtcac ggcgagcgcc gcccggatgg cgtcggcctg ggcggggccg ctggtggaga
     6181 tgccgacggt gacgccaccg gcggcgaact ccgccaggag ggcgtggagc gcggggtcgg
     6241 tgagcgccgg gctgtccggg gtgacggagt ggatctggta cagatcgaga cgctcgccca
     6301 gcagggcgtc ggtctccgcg cgctgccgct cgaaggcctc cacgctgtgg tccttgacct
     6361 cgtggacctc ggcgtcggag cgccagtcgg ccgtgtacgt gtagccccac ttgctgccga
     6421 tcaccacgtc ctggatctcg ggcctggcgc gcagccactg cgcgaggaac tcctcggcgc
     6481 ggccgtagga ccgcgcggcg tcgaaatacc ggacgccctg cgcgtaggcg gcgtccagca
     6541 gttcgtgggc gcgcttgcgc agggcgtcgg ggctgcggcc gccgggcaga tctcggtccc
     6601 ggccgggcgt gatgtacgcc ggacggccga gggccgcgag gccgagtccg aagtgggcgg
     6661 tggcagtggt caccgccgcc agccgggcaa agggcatcgt ggcctccccg cgggtccggt
     6721 cgagtacggt ccctcactac cgtactcaac cgcaccgcgc ggttcagttc ttggcggtgg
     6781 cccaggcgtg ctggatcgcc aagtcggcct tgacctcgtc gagctggacc gcgaccgcgg
     6841 agggcgcggt gccgccgcgc ccgttgcggg aggcgagggc gccggcgacg ttcaggaccg
     6901 tacgcacctc gggggtgagg tgcggggaga tcttggcgaa ctgctcgtcg gtgagctggt
     6961 cgagctcgat gccctgctgc tcgcactcct tgacgcactc accggcgacc tcgtgggcga
     7021 cgcggaacgg cacgccctgc cggaccagcc actcggcgat gtcggtggcg agcgagaagc
     7081 cggccggcgc cagttcctcc atgcgctcgc ggttgacggt gagcgtggcc agcatgccgg
     7141 tgaaggcggg cagcaggact tcgagcgtgt cgcaggagtc gaagaccggc tccttgtcct
     7201 cctggaggtc gcggttgtac gcgaggggca gcgccttcag ggtcgccatc aggccggtga
     7261 ggttgccgat gagccggccg gacttgccgc gggcgagttc ggcgatgtcg gggttcttct
     7321 tctgcggcat gatcgacgag ccggtggaga aggcgtcgtg gagggtgacg aaggagaact
     7381 ccttcgtgtt ccagatgatg atctcttccg cgatccggga gaggttgacg ccgatcatcg
     7441 cggtgatgaa ggcgaactcg gcgacgaagt cgcgcgacgc cgtgccgtcg atggagttgc
     7501 cggaggagcc gcgctcgaag ccgaggtcgg ccgccaccgc ctccgggtcc aggccgaggg
     7561 aggaacccgc cagggcccct gaaccgtacg gcgagacggc cgtccgctcg tcccactgcc
     7621 gcagccgctc ggcgtcccgc gagagggact gggcgtgggc caggacgtgg tgggcgaaga
     7681 ggaccggctg ggcgtgctgg aggtgcgtac ggccgggcat ggccacgtcc gcgtgggcct
     7741 ccgcgaggcc gacgagcgcg tcctggagct cggcgagcag gccgccgatg acgcgggcgt
     7801 ggtcgcgcag gtacatccgg aagagcgtgg cgacctggtc gttgcgggac cgtccggcgc
     7861 gcagcttgcc gccgaggtcg gggccgaggc gctccaggag gccgcgctcc agggcggtgt
     7921 gcacgtcctc gtcggcgatg gtgccgacga aggagccgtt cgcgacatcg gcttcgagct
     7981 ggtcgagacc ggcctgcatg cgttccagct cgtccgccgt gagcagcccc gccttgtgga
     8041 gcacgcgggc gtgggcgcgg gaaccggcga tgtcgtacgg cgcgagacgc cagtcgaagt
     8101 ggacggacgc ggagagcttg gccagggcct cggccggtcc gtcggcgaaa cggccgcccc
     8161 agagccggac gtcaccgttg ttgctgctca cagctactgc tcctcaaggg tggggatgtg
     8221 cgaccgcctc cccgccgcag agggtcgggg aggcggctgt cgaacgagtt cgggttacgc
     8281 caggtcacgt ttcgccgcga tcttcgacga caggccgaag atctcgatga agccctgcgc
     8341 cttggactgg tcgaacgtgt cgcccgagtc gtacgtcgcc aggttgaagt cgtacagcga
     8401 ctcgtcggac ttccggccgg tgacgacggc gcggccgccg tgcagggtca tccggatgtc
     8461 gccggtgacg tgctggttgg cctcgttgat gaaaccgtcc agggcgcgct tgagcgggga
     8521 gaaccacagg ccgtcgtaga ccatctcgcc ccagcgctgc tcgacctgcc gcttgtagcg
     8581 ggccagctcg cgctcgacgg tgacgttctc cagctcctgg tgggcggtga tcagtgcgat
     8641 cgcgccgggg gcctcgtaca cctcacggga cttgatgccc acgagccggt cctcgaccat
     8701 gtcgatccgg ccgatgccct gggcgccggc gcgctcgttg agctgctgga tcgcctggag
     8761 gacggtgacg ggcttgccgt cgatggcgac cgggacgccc tccttgaagg agatgacgac
     8821 ctcgtcggcc tcgcgcggca gcgccgggtt cgaggtgtac tcgtagatgt cctcgatcgg
     8881 ggcgttccag atgtcctcca ggaagcccgt ctcgacggcg cgcccgaaga cgttctggtc
     8941 gatggagtac ggggacttct tggtggtcgc gatcgggagg ttcttctcct cgcagaaggc
     9001 gatcgccttg tcgcgggtca tcgcgtagtc gcggaccggg gcgatgcact tcaggtcggg
     9061 gccgagcgcg gagatgccgg cctcgaagcg gacctggtcg ttgcccttgc cggtgcagcc
     9121 gtgggcgacg atcgaggcgc cgtgcttgtt ggcggcggcg acgaggtgct tgacgatggt
     9181 cggccgcgag agggcggaga ccagcgggta gcggtccatg tagagggcgt tggccttgat
     9241 cgccgggagg cagtactcct cggcgaactc gtccttggcg tccgcgacct cggcttcgac
     9301 ggcaccgcag gcgagcgcgc gcttgcggat gacgtccagg tcctcgccgc cctggccgac
     9361 gtccacggca acggcgatga cctcggcgcc cgtctcctcg gcgatccagc cgatggcgac
     9421 ggaggtgtcc aggccgcccg agtaggcgag tacgacgcgc tcggtcacgg gtttctcctt
     9481 acgatgcatg cggtagtagg cataactatg cagcactccg tatgtttcgt caacccggtc
     9541 cccgaggcgc cggggcgggc ggacgcgatg cgcgaatgcg gatcaaggcc tagcctggaa
     9601 tggcgtacgg cgagcgtgct ccagggcacg gagccggcgc cggatggctg atgacgcgcc
     9661 gctgatgacg cgcccgcgtt cgagtgcgcg ctggggcgac tgtccagcca agaccctcag
     9721 gttcaggttc ctgctgcctt cgcgcacggc tgtggccgcg cgggtcggca catcgagagg
     9781 aacgcgaagg gaggtgtacc gaaatgcgca cctacgagcg tccgaccctg actccgatgg
     9841 gttcgttcgg gaaggtgacc ggcggacgag tcaagaggac aggccctcct gacattctcc
     9901 accgccaccg cctggtcggc tgaggtcacc cgagagaagc ggaaccctgg tggcggtgct
     9961 ggataccgcc accaggcccg tccagcgaaa gcggggcccc atggccggat tgaccggact
    10021 ggcagcggtt ccctcatggt tcgtcgttct tcccgactgc gcggcggcgg gcccccttgc
    10081 gcgggctttg cgcggctacg cggacgtgac cgtcagtcac ccgtcggggc agccatgggt
    10141 gttgggccgg tgggccgtcg acgagatggc cgccgcggag gcgggagaca gcaaagtcgc
    10201 cgtgctgggc cagcacgcga gcgccgaccg gcgccgggtg agccggagcg ccgaacgcgt
    10261 gcggaccccc ggcgatgtcg acgccttggc cgccgaattg acgggcagtt cgcatctgat
    10321 cgcctcggtg gccgggaaag tacgcgtaca gggcaccgtc accggcctgc ggcgggtgtt
    10381 ctccgccgag atcaacggag tcacagccgc ctcggaccgg gccgatgtac tcgcgctgct
    10441 cctcgggtcc ggcatggacg aacggcggct cgccgttcat ctgctggtgc cgcccgtgct
    10501 tcaccccctg tcggacaaac cggtgtggcg ggacgtgacc ttcctgccca ccgaccgcta
    10561 tctgctgctc gacgagagcg gccgtgcccg gcagatccgt tggtggacgc cacccgagcc
    10621 cgagctgccg ttggctcagg gggcgcaacg gctgcgcgcg gcgctgacgg ccgcggtgga
    10681 cgcccgtacc ggaggccgtg atccggtcgg ctgcgatctg agcggactgg actcgacgtc
    10741 ggtgtgctcc ttggcggccc gccggtccaa ggtcgtggcc tgcaccgcgg cgagtcccga
    10801 tccgctcgac gacgacgtgc tgtgggcgac ccgcacggcg gccgcgctcg acggtggcgt
    10861 ggaacaccac gtcatcccgt ccgacgagat gccgctgatt taccacgggc tgctggacgt
    10921 ggacgagttg ttcgacgagc cctgcgggag catcgccgat cacgcccgct ggctcaccat
    10981 cgccggacgc gccgcagcac acgggtgccg gctgcacctg acgggtttcg gcggagacga
    11041 gctgctggcc tcctcgacgt cccacctgct tacgttgctg cgtacgcgcc ccgctgtcgc
    11101 cctgcggcag ctcaacgtcc tggcgacgaa gcacgggtgg tcccgcaagc aactgctccg
    11161 ggagctggcc gaccgtcgtc cgtacgaccg ctggcttctg ggagctgcgg accggctcac
    11221 cactccctcg gcgcaggacg gggtgtcgtt gggctggggg tcccctccga gtctgccgcc
    11281 gtgggccacg ccggaagcgg tcggcgccgt aagggagttg atccgcgcgg aggcacccac
    11341 cgccgagccg ctcgccgggc gccaggggca gcacttcgaa ctggagggaa tccagtacgc
    11401 ggcccacccc gtgcgtcaca tcgcccggct cgccgaccgg gcgggaatca ccctcgccgc
    11461 gccctacttc gacgaccgcg tgctcgaagc gagcctcgcg gtgcggccgg aggagaaggg
    11521 caccccctgg gagtacaagc cgctgatcct ggcggcgatg cgcggcatca tccctccggc
    11581 gagcctgacg cggcagacca aatccggggg aatctgcgac ctcaatgtcg cgctgcgcac
    11641 gaaccgggcg gacctgctcg ccctgtggga cgactcccgg ctgggccggc tgggactgat
    11701 cgacgcggcg gaactgcgcg ggatctgcac ccggcccctc gaccccaacc atccccacga
    11761 tctgcacggc gggctctacc agagcgtggc ctgcgaaatc tggctgcgta cctgggaacg
    11821 ggccgccgcc caaccgaccg cgggagcgat gccatgacac tcaagctgcg taccggcgtg
    11881 tcctgcgccg acaccgacta cggaatcgcg ctgctcgacg aggacagcgg cgagtactgg
    11941 gagctgaacc ccaccggcgc gcaggtcctg cggctcctgc tgcgcggcgg cacctcggag
    12001 caggcggtgc gggacctgac cgatacctgc gacgtcgatg ccgagagcgc gcgcgacgac
    12061 gtacggggcc tggtcgaggc actcgactcg tccggcctgg tggagcggta ggagaaggag
    12121 agcccagtga cctttccgca agccctctct cacgaaccgc gcgcggtgcc cccggcgcgc
    12181 cgggccgaag tgcggctggt cgtcggcctt gcccggctgc tggcgcgtca ccctccgcgg
    12241 cgcatccggg cggtactccg ccgcgtcagc cgtggtgccc gtcccgcgcg ttacgacgag
    12301 gcgctggccg cccgcgagac cgtggtggcc gtcagcctgg cctgcgccgc gccggaaggc
    12361 tgcctgcccc ggtcactggc caccgccctg ctgtgccgcc tgcacggacg gtggccggtc
    12421 tggtgtgtgg gggcgcggcg ggtggcaccg ttcgcggcgc acgcctgggt ggaggccgcg
    12481 ggtgttcccg tcggcgagga cgccccgccc gactacttcc gggccttctt cacggtgcca
    12541 tgagcggcac gggtggcgac ggcgtgcccg gcggcggaca cctcaccgca ccgcgggagg
    12601 tcctgcgcgt actgcgcggg caccggcggt ggatcgcggg cgcggtgacg ctgacgctga
    12661 tcgcttcggc actgggtctg gcccagcctc tggtggtcag gcgagtgatc gactcgtccg
    12721 gtgcggggac ggccgtcgcc gggtccgtcg tcctgctggt cgcgctgttc gtcgcccagg
    12781 cgctggtcga ggcggtggcc ggttacgtcc tggcgcgcac cggagaaggg gtcgttctgg
    12841 gcgtacgcct caacctcatc gaccatctgc tgcggctgcc catgaggacg tacgaccggc
    12901 atcggatcgg cgacctgatc tcgcgggccg ggaccgacag cacagccctg cgcctgctca
    12961 tcgcccaggg cttcaccgac gcggtcaccg gcagcatcgg cctggccggt gtggtcgccc
    13021 tgatgatctg gctcgactgg gccctcttcc tcgtcgtcat cgccatgatc gccttcggcg
    13081 cgctggtcgt cgcctcggtg ctgcgcggca tcgcccgcgc ctcgctccac gcccagcagg
    13141 ccaccggatc gatgaccgcg gaactggagc gggccctggg cgccatccgc accgtacggg
    13201 ccagtcgcgc cgaacggcgg gaggcggacc gcatcggagc acaggcccgg tcggcgttct
    13261 ccgcgggcgt acgggtgggg aagctggacg cggtggtcac accggcgatc gacctgacgc
    13321 tccacgggtc gttcctcgtg gtcctgctca tcggcggcgt acgggtcgcg ggccagggcg
    13381 gctcggtcgc cgacctggcc gccttcctgc tctacatgct ctatctggtg gggccggtcg
    13441 gcgcggtctt ccaggccgtg agcaccatgc agcagggcgc gggagcgctg cggcggatcg
    13501 ccgagatcct cgacctgccg caggagccgg acagcgggcg ccggtacgac gtcacctccc
    13561 cggcgaccga ggtgacccgc ccgccggtat tggagttcag ggacgtctgg ttcggctacg
    13621 acccgcggca tccggtgctg cgcggggtgt cgttcgaggt gccgccacgc ggtcatgtcg
    13681 ccctgatcgg cagctccggc gtcggaaaat cgacggtctt cgcgctggca gagcgcttct
    13741 acgaccccga cgagggactt gtcctgttcg agggccgcga cgtacggacc ctcagccgcg
    13801 cccagcaccg cgcccggatc gggctcgtcg agcagcacgc cccggtcatg tacggcacgc
    13861 tgcgggagaa cctgctgtac gccgcccccg aggccggcgc cggcgaactg gaccgggtgg
    13921 tggagctggc ccagctcacg gagctggcgt cccggctgcc gcgcggcctc gacaccgacg
    13981 ccggggaaca cggcatggcg ctctccggcg gcgaacgcat gcgcatcgcc atcgccaggt
    14041 ccctgctcac ccggcccagc ctgctgctgc tcgacgagcc gaccgcccac ctcgacgccg
    14101 tgaacgaggc ggcgctacgc cggtcgatcc gccggacgag cggcgagtgc gcgctgctgg
    14161 tcatcgcgca ccggttctcg acgatccacg ccgcggacct gatcgtcgta ctcgacgcgg
    14221 gtgagatcgt cgccacgggc agccacgagg aactgctcga caccagtgac cactaccggt
    14281 ctctgtgccg tgcccagcag gtggaggggc ccgagggagc cggccggcgc ccgtgaaccg
    14341 tgcccggcgc cgcgggccct ccccccgaat gcacctcgcc ggggggcggc ctctcgtccg
    14401 tacgccgaag gtggaaacgc gggctgcggg ccaccggaaa gccgtaagga gcagtggaca
    14461 gctatgacgc gaccgaagat cctcgtggtc ggcgcgggtt tcgccggcgt ccagtgcctc
    14521 cagcggctgg aacggaaact ggctccccgc gaggccgagc tggtgctcgt gtcaccgtcc
    14581 gactaccagc tctacctgcc gctgctgccg catgtggcgg cgggggttct caccccgcag
    14641 tccgtcgcgg tgtcgctgcg ccgccggctg cgccgcacgc ggatctgccc cggcggcgcc
    14701 atcggcatcg acggcagggc caaggtgtgc gtcatcagga agatcacggg cgaggtgatc
    14761 gccgaatcgt acgaccagct cgtcctcgtg gccgggagca ccacccgcac cttcgacatc
    14821 cccggcctgc gggaccacgg acgcggcatg aagtccctgg ccgaggcggc ccatctgcgc
    14881 gaccacgtca tcgcccagct cgacatcgcc gccgccacga cggaccaggc cgaacgggag
    14941 gcgcggctgc ggttcgtggt cgtcggcgga ggttacgccg gcaccgagac cgccgcctgc
    15001 ctgcagcgcc tcacctccgc ggcggtcgag cgctacccga atctggaccg ggcgcagatc
    15061 aagtggcatc tggtggacgt ggccccgcgg ctgctgcccg aactcggcga gaagctgggc
    15121 gagaaggcca tggcgatgct gcgctaccgg ggcatcgagt tctcgctcgg cacctcggtc
    15181 gcctccgtcg acgcgacgtc cgtcaggctc accgacggcc gtacgctgcc gtcgcacacc
    15241 ctcatctgga ccgccggagt cgccgcgagc cccctggtgg ccacgctggg agcggagaca
    15301 gtacgcggcc gtctcgccgc cacgccccag ctgaccgtcc ccggcttcga cggcctgttc
    15361 gcggcgggcg acgcggccgc tgtgcccgac gtcgcgaagg gcggcgacgc gatgtgcccg
    15421 ccgaccgcgc agcacgccca gcgccagggc aaggtcctcg ccgacaacat cgtcgcccgg
    15481 ctgcgtggca tgccgctgaa gccgtacgtg cacaaggacc tcggcctggt cgtggacctc
    15541 ggcggccggg acgcggtctc caagcccctg ggcgtggagc tgcacggcct gcccgcccag
    15601 gcggtggccc gcggctacca cctgctggcg ctgcccacca tgaccgccag gacccgggtc
    15661 atgaccaact ggacgctcaa cgcggtcgcc ggtgacgact tcgtccgtac ggacttccag
    15721 gcccgacggg ccggcaccct ccaggacttc gagaacactt ccgtgtacct gacgccggag
    15781 caggtccgtg aacacagcgg gcagccggcg gccaggcact agacaacgag ctcgttgcag
    15841 cagctgaaac actgccaggt atgtgcagtt ggcgcgcata atcattagca tgggaaagct
    15901 ttatgaacgg atagacggcc gaatccgcac cttcatcgag gaccagccgg tcttcttcac
    15961 cgccacagcg ccactgaccg ccgacgggca cgtcaacgta tcgcccaagg ggcgggccgg
    16021 gaccctcgtc gtactggacg aaatgacgct ggcgtacctg gacttcggcg ggagcaccgc
    16081 ggaaaccgtc gcgcacatac gggagaacgg gcgcgtcacc ctgatgtggt gcgccttctc
    16141 cgggccgccc aaggtgctgc gggtgcacgg gcagggtgag gccgtgttcc gggacgattc
    16201 acggtggccg ggtctcatca cgcgtttcaa ggacgtcgac gggccgagcg cccgcgccat
    16261 cgtcgtggtg cacgcgcggc gcatcagcga cagctgcggt ttcgccgtcc cgttcatgga
    16321 gtaccaggag gaacggacgc agcacgccga gcacttcgcc cgcaagacgg acgaggagtt
    16381 cgcggcgtac tgcgagaaga aggagtacct cggcaagagc ctggacggcc tgcccgcgct
    16441 gccgctgccg ctgcccgcgc gggcggactg agccgagcgc ccggcctcgc taacggtcgt
    16501 tctgggccag gcgcaggagg tggtcggcca gcgcctggcc gcccgccggg tcgcggctga
    16561 tcaggagcag cgtgtcgtcg cccgcgatgg tgcccaggac ggcgttcagc tcggcctggt
    16621 cgatggccga ggccaggaac tgggcggccc ccggcggcgt acgcagcacg acgaggttgg
    16681 ccgacgcctc ggcggagatg aggagctcgc cggagaggcg ccgcatgcgc tcctccttgg
    16741 cggactcgcc gaggggcgcg tgcggggtgc ggaagccgcc ctcgctcggt acggcgtaga
    16801 tcagctcgcc gcccgtgttg cggatcttca ccgcgcccag ttcgtcgagg tcacgggaga
    16861 gcgtcgcctg ggtgacgctc agcccgtcgt cggcgaggag cttggccagc tggctctgcg
    16921 agcgcaccgg ctgccggttc aggatgtcca cgatccggcg gtgcctggcg gtgcgggtct
    16981 gcggtacggc aggcccgccg tgctcgtggt cctgcgcctg cgcctcggtc atcggtgtca
    17041 ttctccggat cgtcggtccc cgtgtgcggt gtcgagaacg ccgggcaggg cccggaggaa
    17101 cgtctccacc tcttcgtccc cgatgagata cgccggcatg aggcgtacga catcgggggc
    17161 gggcgcgttc accaggagac cggcgtcctg agccgcctgc tgcacctggg gagcaagaga
    17221 ctcggtgagc acgataccca ggagcagacc cgcaccacgg acgtgggaga ccagcgggtg
    17281 cccgagtgac tcgattccgt cgcgcagctt ctctcccatc cgcttgacgt ggtcgaggag
    17341 tccgtcggcc gcgatggtgt ccagtacggc cagtccggcg gcgcacgcga cggggttccc
    17401 gccgaacgtc gtgccgtgct ggccgggctt gaggaggtcc gcggcagcgc cgaaggcgag
    17461 cgtggcgccg atcggcaggc cgccgccgag gcccttggcg agggtgacga cgtcgggctc
    17521 gacggcgtcg tgcccctggt actcgaacca gtggccggtc cgtccgatgc ccgtctggac
    17581 ctcgtcgagg acgagcaggg tgccggtggc gcgggtgatc tcgcgggcgg cccgcaggta
    17641 gtcctcgggc gggacgacga cgccgaactc gccctggatc ggctcgatga tcagcagtgc
    17701 ggtgtcggtg gtgacggcgg cgcgcagggc gtcgacgtct ccgaagggga cgtgggtgac
    17761 atcgcccggc agcggcagga agggggtccg cttggcctcc tgcccggtga gggcgagggc
    17821 gcccatggtc cggccgtgga acccgccctc ggtggcgacc atgtgcgtac ggccggtgag
    17881 gcgcccgatc ttgaaggcgg cttcattggc ctcggcgccg gagttggaga agaagacgcg
    17941 gccggggcgg ccggagagct ggatcagccg ctcggcgagg gccacgggcg gctcggcgac
    18001 gtacaggttg gagacatggc cgagggaggc gacctggcgg gacacggcct cgacgatcgc
    18061 ggggtgggcg tggcccagcg cgttcacggc gatgcctccg acgaagtcgg cgtactcctt
    18121 gccgtcggcg tcccagacct tcgccccccg gccgcgtacg agcgacagct tgggcgtgcc
    18181 gtagttgtcc gtcatcacgc cctgccagcg ctgcgtcagc tcctggttcg cggtcacttc
    18241 gtcgttcccc cttcgtgctg gtcgggcacg accatcgtgc cgatgccctc gtcggtgaag
    18301 atctccagca ggatcgagtg ctgcacacgg ccgtcgatca cgcgggcggt gttgaccccg
    18361 ttgcgtacgg cgtgcaggca gccctccatc ttggggacca tgccgctgga gagctcgggc
    18421 agcagcctct ccagctcctt ggcggtgagc cggctgatca cttcgtcgct gtggggccag
    18481 tcctcgtaaa ggccctcgac gtcggtgagg accatgagcg tctccgctcc gagcgcggcg
    18541 gccagcgcgg ccgcggcggt gtcggcgttg acgttgaaca cgtggtggtc gtcggcgctg
    18601 cgggcgatgg acgagacgac cgggatacgt ccgtcgtcga gcagggcctg gatggcgccg
    18661 gtgtcgatgg cggtgatctc gccgacccgc ccgatgtcga cggactcgcc gtcgatccgc
    18721 gggtagtgct gggtggcggt gatggtgtgc gcgtcctcgc cggtcatgcc gacggcgagc
    18781 ggcccgtgct ggttgagcag cccgacgagc tcgcgctgca cctggcccgc caggaccatg
    18841 cgtacgacgt ccatggcctc gggggtggtg acccgcagcc ccgccttgaa ctcgctcacc
    18901 aggccgtgcc ggtcgagctg cgcgctgatc tgcgggccgc cgccgtgcac gacgaccggc
    18961 ttgagaccgg cgtgccgcag gaagacgacg tcctgggcga aggcggcctt caggtcctcg
    19021 tcgatcatgg cgttgccgcc gaacttgatg acgacggtcc ggccgtggtg gcgggtgagc
    19081 cagggcagcg cctcgacgag gatctgcgcc ttgggcaggg cggtgtgctt gcgggtgctc
    19141 atgagctgta cgcgctgttc tcgtggacgt agtcggcggt gaggtcgttg gcccagatga
    19201 ccgcggactc ggtgccggac gcgaggtcgg cggtgatcct gacctcccgg tagcgcatgt
    19261 cgaccaggtc gcggtcctcg ccgacgctgc cgttcttgca gacccagacg ccgttgatgg
    19321 cgacgttgag ccggtcgggg tcgaaggcgg ccttcgtggt gccgatcgcg gacagcaccc
    19381 ggccccagtt ggggtcctcg ccgtggatgg cgcacttgag gaggttgtta cgggcgatgg
    19441 agcggcccac ctcgacggcg tcgtcctcgg tcgccgcgtt gatcacctcg atgcggatgt
    19501 ccttgctggc cccctccgcg tcgccgatga gctggcgggc gaggtcgtcg cagacggtgc
    19561 gtacggccgc ggcgaactcg tcgtatccgg gggtcacttc ggacgcgccg gaggccagca
    19621 gcagcacggt gtcgttcgtc gacatgcagc cgtcggagtc gacgcggtcg aaggtgacgc
    19681 gggtggcgtc gcgcagtgcc ttgtcgagta cgccggcttc gaggtcggcg tcggtggtca
    19741 gcacgacgag catggtggcg aggccgggtg cgagcatgcc cgcgcccttg gccatgccgc
    19801 cgacggtcca gccgtcgccg cccgcgacgg ccgtcttgtg gacggtgtcg gtggtcttga
    19861 tggcgatggc ggccttctcg ccgccgtgcg cggagagctc ggtggcggcc ttctcgatgc
    19921 cggggaggag cttgcccatg gggagggtga tgccgatgag gccggtggag gcgacggcga
    19981 tctcaccggc gctgtggccc ttgaggacct ccgcggcttt ctcggccgtg gcgtgggcgt
    20041 cctggaagcc cttggggccc gtacaggcgt tggcgccgcc cgagttgagg acgacggcgg
    20101 agatctggcc gcccttgacg acctgctcgg accacaggac cggcgcggcc ttcacacggt
    20161 tggtggtgaa gacgcccgcg gcggcgaggc ggggcccgtt gttgaccacg agggccaggt
    20221 cgggaccgcc gctgtccttg atccccgcgg cgatgcccgc cgcggtgaat cccttcggtg
    20281 ccgtgacgct cactgcatct cctcgttcgc ttctccgccc gcgcagcgca gcggtgcggc
    20341 tttcgtcatt gcctgcagcc cggcggctgc gcgggcgtcg ctcacggtgc cactcctgtc
    20401 gtggaaagac ctgtgtcctc gggaagtccg agggcgatgt tcatactctg caccgcgccg
    20461 ccggcggtgc ccttggtgag gttgtcgatg gcgctgatcg cgatgacgcg gccggcggcc
    20521 tcgtcgtacg cgacctggat ctggacggcg ttggagccgt acacggaggc ggtcgcgggc
    20581 cactgcccct cgggcaggag gtgcacgaac ggctcgtcgg cgtacgcctt ctcgtacgcg
    20641 tcccgtacgc cggccgctgt cacgcccggc ttcgccttgg cgctgcacgt ggcgaggatg
    20701 ccgcgggaca tgggggccag cgtcggcgtg aaggagacgg tgatccgctc ccccgcggcg
    20761 gcgctgaggt tctggatcat ctcgggggtg tggcggtggc cgccgccgac gccgtacggc
    20821 gacatggaac ccatcacctc gctgccgagc agatgcggct tgagcgcctt gcccgcgccg
    20881 gaggtcccgg tggcggcgac gatcacggcg tcggactccg cgagctgcgc ggcgtacgcc
    20941 gggaagagtg cgagcgagac ggcggtgggg tagcagccgg ggacggcgac ccgcttggag
    21001 ccttcgagcg cggcgcgggc gccggggagt tcggggaggc cgtacggcca ggtcccggcg
    21061 tgcggcgaac cgtagaactg gtcccagtcc gcggcgttct ggagccggaa gtcggcgccc
    21121 atgtcgacga cgagcacctc gtcgccgagc tgctcggcga cggcggcgga ctggccgtgc
    21181 ggaagcgcga ggaacacgac gtcgtgcccg gcgaggacct cggcggtggt cggctccagc
    21241 acccgcccgg ccagcggcag cagatgcggc tggagggagc ccaggcgctg cccggcgttg
    21301 gagtggccgg tcagggcgcc gatctcgacg ccggggtggg cgaggagcag ccggagcagt
    21361 tcaccgcccg cgtatccact cgcccctgcc actgctgcac gtaccgccat cgaatcctcc
    21421 tcgtcgatgg catgactata cgcaaccccg cacttttatg caacgaatgg agtagagccg
    21481 gcccccggaa ctcgcgcctg tgccgaaccc gtggaacggt cgacgcgagt gcatgaccga
    21541 accctgtcgg tattggtcgg cccaccgagc cgctgacatc tggagaccgc gttgttcgtg
    21601 cccaccgcca ccacctgcgt gaccaggtcg ctcgtcaccg ccaccctcgc cgtcggcctg
    21661 ctggccggag ggaccgcgtc cgccggggcg gcgtccggcg gcgaccggac cgtaccggcc
    21721 actgaagtgg cccggcccgc cctcgcctgc aagacggtgc tggccacggt cgtggtggag
    21781 tcggtgaagc gcacagcctc ggaggcgatg aaccacaaca ccgctgtgac gcgtcgcgta
    21841 ctggaaaccc ttgaggccaa cggcgtcgcc ccgcgcgacg cgggcactct gcgtctcagc
    21901 ctgacgcccg tccttgagcc ggacggctca ggcggctccg tggtgaccgg ataccgagtg
    21961 cgccggaccc tcgccgtcac catccgcgcc ggcgaccggg cgaccgccat cctcgacaag
    22021 gcggtggccg cggcgggcgg cgcggcccgc gtcacgtcgg tgtcctgcgc gccctctgac
    22081 ccggcaggca ggcagccgtc gcgcgtgaac acgtccgcgt aagtacgtcc gcgtgagtac
    22141 gtctacggat gcgtaacgcc gccgagatcg acaggctggc cccatgaacg aacacgagct
    22201 cgcctcccga ggccccgtgc ggcccgtccg cgaccaccgg accgcggaaa gggtgatcaa
    22261 ggcgatcctc atcgtggcgg ccgttgtggc cgcgatcgtg gtgccgttca tgtgtctcgt
    22321 catcgccacc tacgccatgg cggactgacc cggagcgacc cggagtgagg ggagcggccg
    22381 ctcggctagc ctgagggcac aatgaaccat ttgacgacgt cactgggcga gtacgacctc
    22441 gttcgcttcc ccgaggaccc ccgcgacagg ctccgcgcct gggacgcggc cgacgagtac
    22501 ctgctgcggc acctcgaagg aaccggcgac actcctccgg cgg
//
