LOCUS       NZ_AUBE01000006        10573 bp    DNA     linear   CON 22-APR-2024
DEFINITION  Streptomyces flavidovirens DSM 40150 G412DRAFT_scaffold00006.6_C,
            whole genome shotgun sequence.
ACCESSION   NZ_AUBE01000006
VERSION     NZ_AUBE01000006.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptomyces flavidovirens DSM 40150
  ORGANISM  Streptomyces flavidovirens DSM 40150
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 401734)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            project_name :: Streptomyces flavidovirens DSM 40150
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: DSM 40150, ATCC 19900
            finishing_strategy                :: Level 1: Standard Draft
            GOLD Stamp ID                     :: Gi11969
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site                    :: Soil
            Sporulation                       :: Sporulating
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-03-07
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000429085.1-RS_2024_04_22
            Annotation Date                   :: 04/22/2024 01:37:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,525
            CDSs (total)                      :: 6,452
            Genes (coding)                    :: 6,216
            CDSs (with protein)               :: 6,216
            Genes (RNA)                       :: 73
            rRNAs                             :: 6, 1, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6 (5S)
            partial rRNAs                     :: 1, 5 (16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 236
            CDSs (without protein)            :: 236
            Pseudo Genes (ambiguous residues) :: 0 of 236
            Pseudo Genes (frameshifted)       :: 106 of 236
            Pseudo Genes (incomplete)         :: 173 of 236
            Pseudo Genes (internal stop)      :: 25 of 236
            Pseudo Genes (multiple problems)  :: 59 of 236
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:04:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 45926
            Orig. end                         :: 56499
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AUBE01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: not full length.
FEATURES             Location/Qualifiers
     region          1..10573
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="1"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10573
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10573
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5573](-)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5573)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(687..1640)
                     /locus_tag="G412_RS0111335"
     CDS             complement(687..1640)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127074.1"
                     /locus_tag="G412_RS0111335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_028812202.1"
                     /transl_table=11
                     /translation="MLHNPSSRPRLSPSSYEEDIQQVLAPRLAHFAAVARHEHVTRAAH
                     ELAVPQSTLSRAMVRLEEDLGVALFARKGRTVSLTPAGRTFLTTVERALSEVERAADSV
                     RADADPATGKVAFGFLHTMGSETVPGLIRAFRADHPRVRFQLVQNYGEAMIERLRAGDL
                     DLCLTSPVPDAPDLVARRLDEQRLRLVVPDDHRLATRKRVRLAEAADEAFVTLEPGYGL
                     RRITDDLCAEAGFKPRVAFEGEEAETLRGLVAAGLGVALLPPPAVARPGVRELTVTAPR
                     AVREIGVAWLDGHPDTPPVAAFKRFLLSRRGHLLPE"
     misc_feature    complement(1593..1608)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.42"
                     /tool="antismash"
     misc_feature    1638..1653
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.73"
                     /tool="antismash"
     gene            1703..3001
                     /locus_tag="G412_RS0111340"
     CDS             1703..3001
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019888956.1"
                     /locus_tag="G412_RS0111340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_028812203.1"
                     /transl_table=11
                     /translation="MPSASTKASTTHVGADAVVVETDSRLAPSSPGYRRMSFALFAAGV
                     ATFALLYSTQALLPLISADFGASASAASWTVSAATGALALFVLPMSALSERFGRSRLMT
                     LSLAVAVAVGLLIPFAPSLEWLVALRAVQGAALAGVPASAMAYLAEEVRPKALIAAIGL
                     FVAGNSIGGMSGRIVTGWAAQVWDWRAALAAVGLMAVVCVVVYRLLLPKARHFTPGSLN
                     PKALAKTVHGHLADPLLLRLYAIGALFMTVFGAVYTVIGYRLVEAPFSLPQGVIGSVFL
                     VYLVGTVSSAAAGKLVARLGRRGALYLAVSTTAAGLLLSVADSLAAVLAGLVLITAGFF
                     AGHAVASSSVSRTAKTGRAQASALYQSAYYLGSSVGGTLGAVAFHAGGWAGTVLLGLVA
                     VLGVVSITLYGTRVARVERRQLVALRTRGAARA"
     gene            3103..4089
                     /locus_tag="G412_RS0111345"
     CDS             3103..4089
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018847318.1"
                     /locus_tag="G412_RS0111345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_028812204.1"
                     /transl_table=11
                     /translation="MSDAVTTQDLDSRLEKHRTELTGYCYRMLGSAFEAEDAVQDTMVR
                     AWRSFDKFEGRSSLRSWLYRIATNVCLDMLSAGNRRARPMDLTAATPVAQAALNSRPEI
                     TWLEPVPDGRVLPSVADPAETAVSRETVRLAFVAALQHLPPKQRAVLILREVLAWKASE
                     VAELLETTVASVNSALQRARATIAEHGSKETATADPLDEEQRKLLERYVAAFEGYDMTA
                     LTALLHEDATLSMPPYDLWLQGHDNIVGWMLGVGEVCRGSKLVPVVANGTPAFAHYHPS
                     QSGDGGFEPWALMVIEIVDGKVSGITSFLDTKRWFPLFDLPARLEKE"
     gene            complement(4121..4984)
                     /locus_tag="G412_RS0111350"
     CDS             complement(4121..4984)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071025.1"
                     /locus_tag="G412_RS0111350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_028812205.1"
                     /transl_table=11
                     /translation="MVYTRKNQRDLTRTEKKRLVSALLELKRSGRYDEFVTMHGRYYVP
                     DADGGPRVSHMAPSFLPWHRRFLLEFERALRAVDPGVSVPYWDWTKDNTPAASLWAEDF
                     LGGNGRAGDRKVTTGAFAHANGNWNLRRRIGDRAFLTRNLGRPSDPVSLPTRQDVAKAL
                     SDPLYDAAPWDSTAAKGFRNRLEGWGRGGTVTTYNHNRVHRWVGGVMMGATSPDDPVFW
                     LHHAFLDLLWDRWQEAHPRSGYLPREKLPASDPQHGRVFSLNEPMPPWNVTPAQLLDHS
                     RVYRYA"
     gene            complement(5001..5573)
                     /locus_tag="G412_RS0111355"
     CDS             complement(5001..5573)
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042438 - melanin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845750.1"
                     /locus_tag="G412_RS0111355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family oxidase copper chaperone"
                     /protein_id="WP_051338289.1"
                     /sec_met_domain="melC (E-value: 1.7e-39, bitscore: 129.8,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLITRRSAATVRGASLTRRILLRGAFAVGVIAGTAGALAPIVTK
                     RLVAGTRPANGPQAAEAAGLAEAAGPTGLAGAAEPAGVADAAQERFAETYRGRHIQATA
                     RAALPTRPACKADRAGAAGDAMTVTAVRDVEVRIDGRPLHIMRRADGSYLSLVNHYESF
                     PTLIGAARAAVDELGDAQLSVSPQHSL"
     misc_feature    complement(5569..5587)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.46"
                     /tool="antismash"
     gene            5916..7208
                     /locus_tag="G412_RS0111360"
     CDS             5916..7208
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003964393.1"
                     /locus_tag="G412_RS0111360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_028812207.1"
                     /sec_met_domain="p450 (E-value: 9.2e-25, bitscore: 81.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPTQASTQQMLRAHNADLADPLFWQLPRSERLKAFALLRGLDA
                     PVLFGESPGSSRRAGRTGKGFYALVKHADVMEASRQPRQFASAPGVTTPEPAAWAKAVF
                     GNSMVNMDGTEHATMRRIVSRAFTPRLLAAAEEDIRDVARRVVDEMLAERPCDFVPSVA
                     SRMPFEVICNLMGIPERYRPEIADRVNHASENVGVRRGVRARLRVPGRGLRALAHMQLV
                     MAKLARERRRHPTGDLISALVRADIDGQSLSSRQLGAFFSLLLVAGVETTRNAIAHGLT
                     LLTEHPEQREVLAADFEQYADGAVDEIVRHSTPIIQFRRTVTTECALGGREFRPGEKVV
                     LFYASANRDEAVFTDPDVFDITRNPNPHLGYGGGGPHYCLGSHLARQEMKALFHELLTR
                     PRDLRAVGIPELVDSNFDNRVRTLRFAFEPS"
     gene            7368..8681
                     /locus_tag="G412_RS0111365"
     CDS             7368..8681
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487582.1"
                     /locus_tag="G412_RS0111365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase"
                     /protein_id="WP_028812208.1"
                     /transl_table=11
                     /translation="MSKRRRLTGTCIGTVAISLAVAGGVFAGGALASPTEPPSPGPAVS
                     PEPGPAVSPEPGPVPSEGPPSAIGAYLDYGPDGVTRMAELSQWLGGAELSVGHTYLPGD
                     LWVNIEGRPEFLRYWADWRRGAQDRLFVLNVPMLERNEEHLSDSEVRDMLEEGAEGSFD
                     HHFQKLATRLVKLGVPDTVIVLGWEMNGTTYSHRCGPDPDSWKEYWHRIVTAMRTVPGQ
                     KFRFDFAPNRGIDAIPWTECYPGDDVVDIIGMDSYDQPPGDTFDDQVSDPYGLQKQVDF
                     AAEHNKAISYPEWGLFRNGDNPEYMRGMLDWMAQHKPLYQTITDYCPHGVWQCDENPRS
                     SEVFRSKLSGWRMPVTQTPVAPAPTPSPSAPTPPQAPTPSATKPSEVKPVKPTPTEPPK
                     KPDSGKWCVPREMGEWINQWLGDFTFCVQPESPERWKS"
     gene            complement(8635..9843)
                     /locus_tag="G412_RS0111370"
     CDS             complement(8635..9843)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346979.1"
                     /locus_tag="G412_RS0111370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_028812209.1"
                     /transl_table=11
                     /translation="MAAAGNRRDRDRGLTVTLCRDPRRFAALQEEWDGLRRRCAAATPF
                     QSHAWLHSWWLSYGRNGRLRVVLARRDGRLIGAAPLMLVHRPMPLLVPIGGAISDFSDV
                     LVDDEEATSAIRALERGLDRAARQAVIDLREVRPGAAAERLYERWTGARARLTDSTCME
                     LPAEPIDDLVKRMQSSRAQRVRAKLRKIDALKIESHVVAGHEVPGAVGRLLRLHELQWR
                     GRGVNVEHLRPRFAEHLVRAASRMLRDGEAAVTEFRLDGEVIAVSMTLQSGLLSGGYLY
                     GADPGLREKKVDVTTMLLRQEAHLAADSGRGVLSLLRGSEPYKNHWRPETVTNQRLLLA
                     RPGLEPLLRVRESQVTMRDRAAETVSTRFPAARDWRDRVNSWRADGTVRISSAPGIPAA
                     HRT"
ORIGIN
        1 acgttcacca ccagcgctcc ggggccgagg ttcagccccg cgcagctcgt cttcgcggcg
       61 ttcgcggccc tggtgctcta cgggctgttc gtgatgacgc agacctggcg gcaccgggac
      121 tacttcctgc ccatgaccac gcagggcaag gtgatcgacg tggagcagca tgccgacccg
      181 ccgtcgcagc gggtcgcgct cttcagtctc ggcctgctcg ccgtctcact ggtcgccgtg
      241 gtggggctgg cgaagggcgt gtccccgacg atcgagtccg gggttgaggc ggccgggctg
      301 cccgcctcgg tggtgggtgt cgtgatcgcg ctgctcgtgc tgctgcccga gtcgatcgcc
      361 gccgtacggg ccgccgggcg cgaccgggtg cagaccagcc tgaacctggc gctcgggtcg
      421 gccatggcga gcatcggact gaccattccg gcggtcgccg tggcgtccgt ctggctggag
      481 gggccgctgc tgctgggcct cggcgcctcg cacatggtgc tgctcgcgct cacggtggcc
      541 gtcggcacac tgaccatcgt gccggggcgc gcgacgccgc tccagggggg cgtacatctg
      601 tcgctgctcg cggcctacat ggtgctcgcc gtcagtccgt aatgtcagtt actcactgac
      661 gtcagtcact cactaaggtc agttactcac tccggcagga gatggccccg gcgcgacagc
      721 aggaagcgct tgaaggccgc caccgggggc gtgtccgggt ggccgtccag ccaggcgacg
      781 ccgatctcgc gtacggcgcg aggggctgtc accgtcagct ccctgacgcc aggccgggcc
      841 accgccggcg gtggcagcag ggcgacgccg agcccggctg ccaccaggcc gcgcagcgtc
      901 tccgcctcct cgccctcgaa cgcgacgcgc ggcttgaagc ccgcctcggc gcacaggtcg
      961 tcggtgatac gccgcagccc gtagccgggt tcgagggtga cgaacgcctc gtcggccgcc
     1021 tccgcgaggc gcacccgctt gcgggtggcc aggcggtggt cgtcggggac gaccaggcgc
     1081 agccgctgct cgtcgaggcg gcgggcgacc aggtcggggg cgtccgggac gggggaggtc
     1141 aggcacaggt cgaggtcgcc ggcgcgcagc cgctcgatca tggcctcgcc gtagttctgg
     1201 acgagctgga agcggacccg tgggtgatcg gcgcggaacg cgcggatcaa gccgggcacg
     1261 gtttccgagc ccatggtgtg caggaagccg aaggcgacct tgccggtcgc ggggtcggcg
     1321 tcggcccgta ccgagtccgc cgcccgctcg acctcggaca gcgcgcgctc gacggtggtg
     1381 aggaaggtgc ggcccgcggg ggtgagggag accgtgcggc ccttgcgggc gaagagggcg
     1441 acgcccaggt cctcctccag cctgaccatg gcgcgcgaaa gcgtcgactg cgggacggcc
     1501 aactcgtggg cggcgcgggt gacgtgctcg tggcgggcga ccgccgcgaa gtgggcgagg
     1561 cgcggcgcga gtacctgctg aatgtcttct tcgtaactac tgggtgacag ccggggccgt
     1621 gagctcgggt tatgcagcat gggattgatt atcgcgcgtt tgtgcattgg acgcatgaag
     1681 ctgccgtgtc tacgttcgat gcatgccttc tgccagtacc aaggcgtcca ccacccacgt
     1741 gggcgccgac gccgttgttg tcgaaaccga ctcccgtctc gccccctcct cccccggcta
     1801 ccgccgcatg agcttcgcgc tcttcgccgc cggggtggcg accttcgccc tcctctactc
     1861 cacccaggcg ctgctgccgc tgatctccgc cgacttcggc gcgagcgcga gcgccgccag
     1921 ctggaccgtc tcggccgcca cgggtgcgct ggccctgttc gtcctgccga tgagcgccct
     1981 ctcggagcgc ttcgggcgca gccgcctgat gacgctctcg ctggcggtcg ccgtcgcggt
     2041 cggcctgctg attcctttcg cgccctcgct ggagtggctg gtggcgctgc gcgccgtgca
     2101 gggcgccgcg ctggccggtg tgcccgcttc cgcgatggcg tatctcgcgg aggaggtccg
     2161 gccgaaggcg ctgatcgcgg cgatcgggct gttcgttgcg ggcaactcca tcggcggcat
     2221 gagcggccgc atcgtcaccg gctgggccgc ccaggtgtgg gactggcgcg cggcgctcgc
     2281 cgccgtcggc ctgatggccg tggtgtgcgt ggtggtctac cggctgctgc tgccgaaggc
     2341 ccgtcacttc acgcccggtt cgctgaaccc gaaggcgctg gcgaagaccg tccacggtca
     2401 cctcgccgat cctctgctgc tgcgtctgta cgccatcggc gcgctcttca tgacggtctt
     2461 cggcgcggtc tacacggtga tcggctaccg gctggtcgag gcccccttca gcctcccgca
     2521 gggcgtcatc ggatctgtct tcctggtgta cctcgtcggt accgtctcct ccgcggcggc
     2581 cggaaagctg gtggcccgcc tgggccgccg gggcgcgctg tatctggcgg tctcgacgac
     2641 ggcggccggt ctgctgctct cggtggccga ttcgctggcc gccgtcctgg cgggcctggt
     2701 gctgatcacc gccggtttct tcgctgggca cgcggtggcg tcgtcctcgg tcagccgtac
     2761 ggcgaagacg gggcgggcgc aggcgtccgc gctctaccag tcggcgtact acctgggcag
     2821 cagcgtcggc ggcacgctcg gcgcggtggc cttccacgcc gggggctggg cggggaccgt
     2881 gctcctcggg ctggtcgcgg tgctcggcgt cgtatcgatc acgctgtacg ggacccgggt
     2941 cgccagggtc gaacggcggc agctcgtggc gctgcggacg aggggcgcgg cgcgggcctg
     3001 agtccctccg gtggggcggg tttcgcggct gggccatgat tgtcagtggg gtccggtaac
     3061 ttcccaaggg ctggtgccaa aggcggcgag tggggtggac cgatgagtga tgccgtgacg
     3121 acgcaggatc tggattcccg gctggagaag caccggaccg agctgaccgg ctactgctac
     3181 cggatgctgg ggtccgcctt cgaggcggag gacgccgtgc aggacacgat ggtccgggcg
     3241 tggcggagct tcgacaagtt cgagggacgc tcgtcgctgc ggtcgtggct gtaccgcatc
     3301 gcgacgaacg tatgcctgga catgctcagc gcgggcaacc gcagggcccg ccccatggac
     3361 ctcacggccg cgaccccggt ggcgcaggcc gcgctcaact cccgtcccga gatcacctgg
     3421 ctggagccgg tgccggacgg gcgggtgctg ccctcggtgg ccgacccggc cgagacggcc
     3481 gtgtcgcgcg agaccgtgcg cctcgcgttc gtcgccgcgc tccagcacct gccgcccaag
     3541 cagcgggccg tgctgatcct gcgcgaggtg ctggcctgga aggcgagcga ggtcgcggag
     3601 ctgctggaga cgacggtcgc ttcggtgaac agcgcgctcc agcgggcccg cgcgacgatc
     3661 gccgaacacg gctccaagga gacggccacc gccgatccgc tggacgagga acagcggaag
     3721 ctgctggagc ggtacgttgc ggccttcgag gggtacgaca tgaccgccct gaccgcgctg
     3781 ctccacgagg acgccacgct gtccatgccg ccgtacgacc tgtggttgca gggccacgac
     3841 aacatcgtcg gctggatgct gggcgtcggc gaggtctgcc ggggctccaa gctggtgccg
     3901 gtcgtggcca acggcacgcc ggccttcgcc cactaccacc cgagccagtc cggcgacggc
     3961 ggcttcgagc cgtgggcgct catggtcatc gagatcgtgg acgggaaggt cagcgggatc
     4021 acgtccttcc tggacacgaa gcgctggttc ccgctcttcg acctgcccgc gcggctcgaa
     4081 aaggagtagg agctgtccgg cggattatgg gggacagacc ctaggcgtag cggtagacgc
     4141 ggctgtggtc cagcagttgc gcgggcgtca cattccacgg cggcatcggc tcgttgaggc
     4201 tgaagacccg cccgtgctgc gggtcggacg cgggcagctt ctcgcgcggc agataaccgg
     4261 agcgggggtg ggcctcctgc cagcggtccc agagcaggtc caggaaggcg tggtggagcc
     4321 agaaaaccgg gtcgtcgggc gaagtggcgc ccatcatcac accgccgacc cagcggtgga
     4381 cccggttgtg gttgtacgtc gtgaccgtgc cgccgcgccc ccatccctcg agcctgttcc
     4441 ggaagccctt ggccgcggtc gagtcccacg gcgccgcgtc gtacagcggg tcgctcagcg
     4501 ccttggccac gtcctgacgg gtgggcagcg agacggggtc ggagggccgg cccaggttgc
     4561 gggtgaggaa ggcgcggtca ccgatccgtc tgcggaggtt ccagttcccg ttggcgtggg
     4621 cgaacgcccc cgtcgtcacc ttcctgtcgc cggccctgcc gttgcctccg aggaagtcct
     4681 cggcccacag cgaggccgcc ggagtgttgt ccttcgtcca gtcccagtac gggaccgaaa
     4741 caccgggatc gacggcccgc agggcgcgct cgaactccag gaggaagcgg cggtgccacg
     4801 ggaggaagga gggcgccatg tgactgacgc gcggcccgcc atcggcgtcc gggacgtagt
     4861 accggccgtg catggtcacg aactcgtcgt agcgccccga gcgcttgagt tccaggagcg
     4921 cactgaccag gcgcttcttc tccgttcggg tgaggtcgcg ctggttcttc cgggtgtaaa
     4981 ccacgtctgc cctcccggct tcagaggctg tgctgggggg acaccgacaa ctgggcgtcg
     5041 cccagctcgt ccaccgcggc gcgtgccgcg ccgatgagcg tcgggaacga ctcgtagtgg
     5101 ttcaccaggc tcagatagct gccgtcggcg cgccgcatga tgtgcagcgg ccggccgtcg
     5161 atgcgcacct cgacgtctcg tacggcggtg acggtcatgg cgtcaccggc cgccccggcg
     5221 cggtctgcct tgcaggccgg cctcgtgggc agcgcggccc tcgcggtcgc ctggatgtgc
     5281 cggccgcggt atgtctcggc gaaccgctcc tgtgccgcgt ccgccacccc ggccggctcg
     5341 gccgcccctg ccagccctgt cggccccgcc gcctctgcca gtcccgccgc ctctgccgcc
     5401 tgcgggccgt tcgccgggcg ggtgcccgcc acgagcctct tggtgacgat gggggcgagc
     5461 gcccccgcgg tgcccgcgat cacgcccacc gcgaaggcgc cgcgcagcag aatgcggcgc
     5521 gtcagggagg cccctcgcac ggtcgctgcg ctcctgcgcg tgatcaggtc catgctgaat
     5581 accccttgcc gctcgcgttg ttccactctt tcgacgtacg catgcctcgg tgctgacaac
     5641 aacgacgcat cggcgaaaca gttctcgtag gcggccggcg ctcccctcag tccgggcctt
     5701 ccaagacggc gcgcggcgca cccaggtccc cttcaaatgc cgccgcgaca caacctcggg
     5761 tggtcaactt catcggtagg tgaattccct ctgcctcgca gacacgctgt tgctctgcaa
     5821 gaacgagcca aacacccgaa ccagtgcata gttcccccgt ccgcagcaac tggttcgggc
     5881 caaaacgacc gcccgagctc ctgaagggtg tgggtatgaa gatcccgacg caggcgtcca
     5941 cgcagcagat gctgcgcgcg cacaacgccg atctcgccga tccgctgttc tggcaactgc
     6001 cgcgctccga acggctgaag gccttcgcgc tgctgcgcgg gctcgacgcc ccggtgctct
     6061 tcggggagag tccgggctcc tcccgccggg ccgggagaac cggcaagggc ttctacgcgc
     6121 tggtgaagca cgccgacgtg atggaggcga gccggcagcc gagacagttc gcgagcgctc
     6181 cgggggtcac cactccggag ccggccgcct gggccaaggc ggtgttcggg aactcgatgg
     6241 tcaacatgga cggcaccgag cacgccacga tgcgcaggat cgtctcccgc gccttcacgc
     6301 cgcgcctgct cgccgccgcg gaggaggaca tccgggacgt cgccaggcgt gtggtggacg
     6361 agatgctcgc cgagcggccg tgcgacttcg tgccgtcggt cgcttcccgt atgccgttcg
     6421 aggtcatctg caacctgatg ggaatcccgg agcgctaccg gcccgagatc gccgaccgcg
     6481 tcaaccacgc gtccgagaac gtcggcgtgc ggcgcggcgt gcgggcccgg ctgcgggtgc
     6541 ccggacgcgg tctgcgcgcc ctggcccata tgcagctcgt catggcgaag ctcgcccgtg
     6601 agcgccgccg ccaccccacc ggtgacctga tctcggcgct ggtacgcgcg gacatcgacg
     6661 gccagtcgct ctcctcccgc cagctcggcg ccttcttctc cctgctgctg gtcgccgggg
     6721 tggaaaccac gcgcaacgcg atcgcccacg ggttgacgct tctcaccgaa caccccgagc
     6781 agcgcgaggt gttggccgcg gatttcgagc agtacgccga cggggcggtg gacgagatcg
     6841 tccgccactc gacgccgatc atccagttcc gccgtacggt cacgaccgaa tgcgcgctgg
     6901 gcggccggga atttcggccc ggcgagaagg tggtgctctt ctacgcctcc gccaatcgcg
     6961 acgaagcggt gttcacggac cccgatgtct tcgacatcac ccggaacccg aatccgcatc
     7021 tgggatacgg cgggggcggg ccgcactact gcctggggtc acatctggcc cggcaggaga
     7081 tgaaggcgct gttccatgaa ctgctgaccc ggccgcgaga tctgcgggcg gtgggaattc
     7141 cggaactcgt cgactcgaac ttcgacaacc gcgtccgcac gctgcgtttc gctttcgaac
     7201 cgtcctgatc cggtcccgcc agaaccatca atttcactcg cgtggccgat ttgaaggagg
     7261 gcccttgtcg ccaatggcct actgacgagc attcagacag cccattagta cgacttcctg
     7321 cctactgtcg aagcgtcggc aacaacgacc gatcggtagg aggagtcatg tcaaagaggc
     7381 gccgtctcac cggcacctgt atcggcacgg ttgccataag tctcgccgtc gccggtggtg
     7441 ttttcgcggg aggggccctg gcatccccca ccgagccccc gtccccgggt ccggctgtga
     7501 gtcccgagcc gggcccggct gtgagtcccg agccgggccc ggtcccgtcc gaagggcccc
     7561 cgtcggccat cggcgcgtat ctcgactacg gccctgacgg cgtgacacga atggctgagc
     7621 tgtcgcagtg gctgggcggt gcggaactgt cggtcgggca cacctacctg ccgggcgacc
     7681 tctgggtgaa catcgaaggc cgtcccgagt tcctgcggta ctgggcggac tggcggcgcg
     7741 gcgcgcagga ccggttgttc gtcctcaatg tgcccatgct ggagcggaac gaggagcacc
     7801 tgtccgacag cgaggtgcgc gacatgcttg aggagggcgc cgagggaagc ttcgaccacc
     7861 acttccaaaa actcgccacg cgcctggtga agctcggcgt accggacacc gtgatcgtcc
     7921 tcggctggga gatgaacggc accacgtact cgcatcgctg cgggcccgac cccgactcct
     7981 ggaaggagta ctggcaccgc atcgtcacgg cgatgcgtac cgttcccggc cagaagttcc
     8041 gcttcgactt cgccccgaac cggggcatcg acgcgattcc gtggaccgag tgctatccgg
     8101 gcgacgacgt cgtggacatc atcggcatgg attcgtacga ccagccgccc ggcgacacgt
     8161 tcgacgacca ggtgtccgat ccgtacgggc tgcagaagca ggtcgatttc gccgccgagc
     8221 acaacaaggc catctcctac ccggagtggg ggctcttccg caacggtgac aaccccgagt
     8281 acatgagggg gatgctcgac tggatggccc agcacaagcc gctctaccag accatcaccg
     8341 actactgtcc gcacggcgtc tggcagtgcg acgagaaccc ccggtcctcg gaggtgttcc
     8401 gttcgaagct gtccgggtgg cggatgcccg tgacgcagac gccggtcgcg ccggcgccca
     8461 caccctcgcc gtcggccccg acgccgcccc aggcacccac gccgtccgcg acgaaaccct
     8521 cggaggtcaa accggtcaag cccacgccca ccgagccccc gaagaagccg gactccggga
     8581 aatggtgcgt gccgagggag atgggcgagt ggatcaacca gtggctgggc gacttcacgt
     8641 tctgtgtgca gccggaatcc ccggagcgct ggaaatcctg acggtgccgt ccgcccgcca
     8701 gctgttcacc cggtcccgcc agtcgcgcgc cgcgggaaag cgcgtactca cggtctcggc
     8761 ggcccggtcc cgcatggtca cctgcgactc gcgcacgcgc agcaggggtt ccaggccagg
     8821 ccgggccagc agcagccgct ggttggtgac ggtctccggc cgccagtggt tcttgtacgg
     8881 ttccgatccg cgcagcaggc tcagcacgcc ccggccggag tccgccgcca ggtgcgcctc
     8941 ctggcgcagc agcatcgtcg tgacgtccac cttcttctcc cgcagccccg gatcggcccc
     9001 gtacaggtag ccgccggaga gcagacccga ctggagggtc atgctcacgg cgatcacctc
     9061 gccgtccagc cggaactccg tgaccgcggc ctcgccgtcc ctcagcatcc ggctcgcggc
     9121 gcgcaccagg tgctcggcga agcgcggcct gaggtgttcc acgttgacgc cgcggccccg
     9181 ccactggagt tcgtgcagcc tcagcagacg gccgaccgcg ccgggcacct cgtgcccggc
     9241 gaccacgtga ctctcgatct tcagtgcgtc gatcttgcgc agcttggccc gtacgcgctg
     9301 ggcgcggctg ctctgcatcc gcttgacgag gtcgtcgatc ggctcggcgg gcagctccat
     9361 gcaggtcgag tccgtgagcc gggcccgggc gccggtccac ctctcgtaca gccgctcggc
     9421 cgccgctccc ggccgtacct cccgcaggtc gatcaccgcc tgccgggcgg cacggtcgag
     9481 tcctcgttcg agtgctcgga tcgcgctcgt cgcctcttcg tcgtcgacga gtacgtcgga
     9541 gaagtcggag atcgcaccgc cgatgggcac gagcagcggc atcgggcggt gtacgagcat
     9601 cagcggcgcg gcgccgatca gccggccgtc acggcgggcc agtacgacgc ggagccggcc
     9661 gttccgcccg tacgagagcc accacgagtg gagccaggcg tggctctgga acggcgtcgc
     9721 cgcggcgcag cggcgacgga gcccgtccca ctcctcctgg agcgcggcga accgccgggg
     9781 gtcgcggcac agcgtgacgg tcaggccccg gtcccggtcc cgccggttcc cggccgccgc
     9841 catcacacca gctcccgctc ggctttggcg gtcgcgctcg cgttgccgtt ggcgttgggg
     9901 ttggtgttgg cgttggggtt ggcgtgactt tcggcggggg cggcggacgg tgcgggcacc
     9961 gacgccgacg cggtcgcgcg ggggcgcttc ggccgtacga gaaggaccag tccgccgatg
    10021 aggccgccgg tgctcccgcc cacagccgcg ctgatcggga gggacggcga ggccgcctcg
    10081 gtcggcgcga tcgcctggga gaagacgagc agcttgacgc cggtgttctt ggagacgtgg
    10141 ttgctgctga cgaacacggc ttcggcgacg gcgttggcga tgtccgccgc cacggcgggc
    10201 ttgtcggcgg tcccggtgat cgcgatcatc ggcgagtcgg gggacgtctc ggtactgacc
    10261 tgggtacgca gcgccttcgg cggaactccg gccgccacgc gcgcgtacgc gagggtggag
    10321 tcgctggtgg tgatccggcc gtacgcctgg gcgtagccga gggccgcggt gggctcggtg
    10381 cccttggcgg ggacggctac gacgtaactg gtggcggcgt actccggggt ctggagggcg
    10441 ccgtatgcca ctccgcacac cgtgccgagc acggcgcata cgggcagcgg ccaccagacg
    10501 ggcacgggaa tggcctggat cgtggcctgg accttgggtt tgatcttgag tttgatgttg
    10561 ggtttgatct tcg
//
