LOCUS       NZ_KE384533            23052 bp    DNA     linear   CON 02-MAY-2024
DEFINITION  Nocardioides alkalitolerans DSM 16699 K329DRAFT_scaffold00001.1,
            whole genome shotgun sequence.
ACCESSION   NZ_KE384533
VERSION     NZ_KE384533.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Nocardioides alkalitolerans DSM 16699
  ORGANISM  Nocardioides alkalitolerans DSM 16699
            Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
            Nocardioidaceae; Nocardioides.
REFERENCE   1  (bases 1 to 1380937)
  AUTHORS   Kyrpides,N., Huntemann,M., Han,J., Chen,A., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            country                           :: South Korea
            environment                       :: Soil
            investigation_type                :: bacteria_archaea
            isol_growth_condt                 :: 15774667
            project_name :: Nocardioides alkalitolerans DSM 16699
            sequencing_meth                   :: WGS
            ref_biomaterial                   :: DSM 16699
            rel_to_oxygen                     :: Aerobe
            finishing_strategy                :: Level 1: Standard Draft
            GOLD Stamp ID                     :: Gi11710
            Type Strain                       :: Yes
            Funding Program                   :: DOE-CSP 2012
            Isolation Site                    :: Alkaline serpentinite soil
            Cell Shape                        :: Rod-shaped
            Sporulation                       :: Nonsporulating
            Temperature Range                 :: Psychrotolerant
            Temperature Optimum               :: 25-30 C
            pH                                :: 5.5-12.0
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-04-19
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000426525.1-RS_2024_05_02
            Annotation Date                   :: 05/02/2024 01:43:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,653
            CDSs (total)                      :: 4,598
            Genes (coding)                    :: 4,584
            CDSs (with protein)               :: 4,584
            Genes (RNA)                       :: 55
            rRNAs                             :: 2, 3, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 2, 2 (16S, 23S)
            tRNAs                             :: 45
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 14
            CDSs (without protein)            :: 14
            Pseudo Genes (ambiguous residues) :: 0 of 14
            Pseudo Genes (frameshifted)       :: 1 of 14
            Pseudo Genes (incomplete)         :: 13 of 14
            Pseudo Genes (internal stop)      :: 1 of 14
            Pseudo Genes (multiple problems)  :: 1 of 14
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 10:19:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 876581
            Orig. end                         :: 899633
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KE384533.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 1013810
            Source DNA and organism available from Hans-Peter Klenk at the
            German Collection of Microorganisms and Cell Cultures (DSMZ)
            (hans-peter.klenk@dsmz.de)
            Contacts: Nikos   Kyrpides (nckyrpides@lbl.gov)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI
            Annotation by JGI
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23052
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="3"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..23052
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23052
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13052](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13052)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    172..186
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     misc_feature    complement(580..594)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            complement(749..2584)
                     /locus_tag="K329_RS0121045"
     CDS             complement(749..2584)
                     /EC_number="4.1.1.32"
                     /GO_function="GO:0004611 - phosphoenolpyruvate
                     carboxykinase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0017076 - purine nucleotide binding
                     [Evidence IEA]"
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007079167.1"
                     /locus_tag="K329_RS0121045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphoenolpyruvate carboxykinase (GTP)"
                     /protein_id="WP_028474584.1"
                     /transl_table=11
                     /translation="MANVEAALDAAGLKNPHVREYVAYWAEVTGAERVEVVNASDDARL
                     LAEAVEAGELEPAGDGLYYSRSYQKDTARSEERTIVATSNPADKGVYNNWRPADEMKEL
                     LTSKMRGASAGKTMYVIPYLMAPPGSPLEAYAAGVELTDTRTVVLHMIRMARVGAHHID
                     ALEDPNSFVRAVHVTGDLPNLGQGTPDDQRYFVTVADERTILHFGSSYGGNALLGKIAH
                     GLRQAAYDGWASKKFLAEQFMLLGIVDKETGRKYHICGGFPSASGKTNLAMTLAPDALG
                     DRYHVEFYGDDIAWLWVGEDGRLYGMNPEFGVFGVAKDTNELTNPTALHSIAEGTGALF
                     TNIAYNTTTQEVWWEGKTPEHPTDLDGWTDWKGESIAERAEGVDAPWAHPNSRFTTTLA
                     NVPNVAADFEEPAGVPIDAIIFGGRTRDREPLVRAIHDLAEGVYDGLTLGAEATFAADG
                     LDGQLRYDPMSMRPFMSYDEAKYAEHWLNIVGAASEQPIFAHVNWFQRDAEDGHFLWPG
                     YRENLRPLLWLMQLKNGEVTGRQTPVGIIPTAEELNLDGLDLPAEDLERILNIDNERWR
                     QEIGFREEHLQQFDGLPEAIWEAHRRVAAALDAEA"
     misc_feature    2607..2620
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.98"
                     /tool="antismash"
     misc_feature    2760..2773
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            2760..3368
                     /locus_tag="K329_RS28555"
     CDS             2760..3368
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011753909.1"
                     /locus_tag="K329_RS28555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YitT family protein"
                     /protein_id="WP_043644350.1"
                     /transl_table=11
                     /translation="MTEIQVVPHSPFENMFGVLTGTFVASFGLVLLTEAQAVTGGTAGL
                     ALLASYGLPMSFGLLFLLVNVPFFALALKVKGWQFTLRTLVCVGLVSAMSALHESMLDI
                     DRISAPYAAVGGNLIAGIGLLIVFRHGASLGGFNIVALVAQERLGWRAGYVQMVLDVLV
                     VVGALTVVAPQNVLLSAVGAVVLNLVLALNHRPGRYTGA"
     gene            complement(3449..4618)
                     /locus_tag="K329_RS28560"
     CDS             complement(3449..4618)
                     /EC_number="2.7.1.31"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008887 - glycerate kinase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00045.1"
                     /locus_tag="K329_RS28560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycerate kinase"
                     /protein_id="WP_043644353.1"
                     /transl_table=11
                     /translation="MPTAEQRHRSLRVAIVPDSFKGSASASEVAEAMAAGVRDAASSSG
                     VGLEIRTLPFADGGEGTLDALLGAWGTDARTTATTDALGRPTTARYGVSPDGTSAIVEA
                     AEANGLPRVSDVPLQPLAASTHGVGVLARAVLDAGCTDVLLCIGGSATTDGGTGMLRAL
                     GVRFLAADGTELPDGGGHLRDLATLDTSGLDPRAAAARWRIACDVTNPLVGERGAAAVF
                     GPQKGATPADVEVLDAGLSRLADVLADHTGVEVRDLPGAGAAGGMPAALTALLGAEIAP
                     GGLLVADTLGLPALLDGVDLVLTGEGRLDSQSFGGKVVDTVRGLTPPAVPVVVVAGSVQ
                     VDAATLADAGITAAFSIANGPQELSEMSTGAVAAVTATTTQVVRLLLAR"
     gene            complement(4694..5893)
                     /locus_tag="K329_RS28565"
     CDS             complement(4694..5893)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017466.4"
                     /locus_tag="K329_RS28565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar diacid recognition domain-containing
                     protein"
                     /protein_id="WP_052337190.1"
                     /transl_table=11
                     /translation="MLADAGPGDEAGARPDDPGPLPGPGSLDAQIGQRVVDVVASTIRQ
                     DLNLMDAHGTVIASTVADRIGRPHRAARRVLSTGRPVAVTQVVEGVVDRPGINVPLEVD
                     GELAGVVGVTGDPEQVEQLAHVVALTIQLLITQEREHDSDHLTRTLARELVATLCSSTA
                     SAPAVRERLAATGLGVGPWSIGVWAATVPHQDGSATPPRHAEHLVTTTNDRRADARPGS
                     SAPAGATCAIVLHGLLWVVTSGGRRLDPSLGGAGTRAVVVDALDDVDELASWAHDLRAL
                     GRLARLLPHAADRATWNADLAVTVAHLPDSTRRRLARTAARLAPVHRETVRAVTRAPSL
                     SAGAALLFVHRNTLLQRVERIRTLTGLDLRRADDAAVLRSATMAYDAVAADGDEGRTHT
                     "
     gene            complement(5976..6644)
                     /locus_tag="K329_RS31540"
     CDS             complement(5976..6644)
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020389013.1"
                     /locus_tag="K329_RS31540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="C40 family peptidase"
                     /protein_id="WP_245596634.1"
                     /transl_table=11
                     /translation="MHSESTVPAPSRAGLHQPLHRAEGRARVLARSTSSPTTGTTSTGA
                     RPEAGSLRRTVTATGLAVAAVVSTAAMSVGATTAPASAAASTTSSKAAAQAEFMRHYDY
                     RNWKVLKNAQSLQGTPYRYGGTNPSSGFDCSGFTSYVYAKAGKSLPRTSSQQLGAVVRV
                     TASQVRPGDLVFFHNGGRVYHVAIYAGNNQVWHAPGSGESVKKERIWSTSAYFGRVPLA
                     "
     misc_feature    complement(6929..6945)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    complement(6934..6948)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.62"
                     /tool="antismash"
     misc_feature    complement(6935..6948)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.49"
                     /tool="antismash"
     gene            7028..7678
                     /locus_tag="K329_RS28570"
     CDS             7028..7678
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017933061.1"
                     /locus_tag="K329_RS28570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_052337191.1"
                     /transl_table=11
                     /translation="MEPLETSAWREYGAPDLPRVLLAALDAFAEQGYHGTSIRELASRA
                     QLSVPGLYHHYSSKQDILVDLLEAVMREVIDRSEAALAAAAPDSLSRFDALVECVLRFH
                     MFRNQGAFVTSSELRSLTPANRATIVGLRDHQQQLIDRAVDAGVADGTFATPYPKAASR
                     AVTVLCTGVASWYRADGELSPDELVRRHLVLAHGLVGVQGRAAGLTVVPAEGP"
     gene            complement(7823..8428)
                     /locus_tag="K329_RS28575"
     CDS             complement(7823..8428)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF036525.4"
                     /locus_tag="K329_RS28575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_052337192.1"
                     /transl_table=11
                     /translation="MAVSTLPGLDPESLAGLSTRDRILRAAVALFATKGYAATSLSDIE
                     ELVQVKRGALYYHISTKQELLYMVVTQYVSDVLAVAEQAVAEGTGAERLRGLIRTHVVS
                     VIRYRHQQAITIRDLDHLAPERAAELREVLDRVDALWHQALDTGAADGTLAPTDTAVMN
                     AIIDTANGPWRWFDEGGTYSPEQLGERYADLWLRALAP"
     misc_feature    complement(8496..8511)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.35"
                     /tool="antismash"
     gene            complement(8508..9245)
                     /locus_tag="K329_RS0121080"
     CDS             complement(8508..9245)
                     /NRPS_PKS="Domain: PKS_KR (40-147). E-value: 2.7e-08.
                     Score: 25.9. Matches aSDomain:
                     nrpspksdomains_K329_RS0121080_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017936754.1"
                     /locus_tag="K329_RS0121080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mycofactocin-coupled SDR family oxidoreductase"
                     /protein_id="WP_028474586.1"
                     /transl_table=11
                     /translation="MSGRRVALVTGAAGGIGTATLAALARDGYDVVGVDVAPVTGPAVE
                     SHVVDVRDAPALAALAADVVARRGRLDAVVAAAAVVGGGAPLWETPPEVLDELWEVDAK
                     GVWTTAAVTVPHLLAGPEPHLARFVAIASAAGEHGLFSLSAYTTVKHAVIGIVRGLAAD
                     LVGTGVTAVAVSPGATRTPMLTATAALYGLSGEEGIAELARHQGLRRPLEPAEIADVVA
                     ACCSPAGAALHGSVVSADGGFGI"
     aSDomain        complement(8805..9125)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K329_RS0121080_PKS_KR.1"
                     /evalue="2.70E-08"
                     /label="K329_RS0121080_PKS_KR.1"
                     /locus_tag="K329_RS0121080"
                     /protein_end="147"
                     /protein_start="40"
                     /score="25.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="GPAVESHVVDVRDAPALAALAADVVARRGRLDAVVAAAAVVGGGA
                     PLWETPPEVLDELWEVDAKGVWTTAAVTVPHLLAGPEPHLARFVAIASAAGEHGLFSLS
                     AYT"
     CDS_motif       complement(9168..9224)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K329_RS0121080_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="K329_RS0121080"
                     /protein_end="26"
                     /protein_start="7"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LVTGAAGGIGTATLAALAR"
     gene            complement(9242..9997)
                     /gene="mftE"
                     /locus_tag="K329_RS28580"
     CDS             complement(9242..9997)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftE"
                     /inference="COORDINATES: protein motif:HMM:TIGR03964.1"
                     /locus_tag="K329_RS28580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="mycofactocin biosynthesis peptidyl-dipeptidase
                     MftE"
                     /protein_id="WP_052337193.1"
                     /transl_table=11
                     /translation="MVPALTPRSWPDVETGGLLLVPVGSIEQHGPHLPLDTDSVIAGEV
                     ASRVAVHLADEVPVLVAPPIVYGASGEHHGFPGTLSIGTEVLTTLLVELVRSAQLWADR
                     MVFVNAHGGNVFALTAAVTRLRAEGHDAAWVACATEEVDLHAGLTETSIMLHLRPADVD
                     VRRAEAGCTDALSEILPTLMSGGVRAVSPNGVLGDPTGATAEHGRVLVAGIVRDVLHAV
                     RHGLPDERGLLHPAAVHPERSGAVGGAGG"
     misc_feature    complement(9995..10014)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 23.76"
                     /tool="antismash"
     gene            complement(10001..11236)
                     /gene="mftD"
                     /locus_tag="K329_RS0121090"
     CDS             complement(10001..11236)
                     /EC_number="1.4.3.26"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR03966"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017936752.1"
                     /locus_tag="K329_RS0121090"
                     /note="MftD, an enzyme found in the mycofactocin
                     biosynthesis locus, performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases.; MftD,
                     an enzyme found in the mycofactocin biosynthesis locus,
                     performs an oxidative deamination of
                     3-amino-5-[(p-hydroxyphenyl)methyl]-4,
                     4-dimethyl-2-pyrrolidinone (AHDP). The resulting compound,
                     now called pre-mycofactocin (PMFT), is a biologically
                     active redox cofactor that can oxidize the non-exchangeable
                     NADH of TIGR03971 family SDR-type oxidoreductases; Derived
                     by automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="pre-mycofactocin synthase MftD"
                     /protein_id="WP_028474587.1"
                     /sec_met_domain="TIGR03966 (E-value: 3.2e-188, bitscore:
                     621.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPEWLSKVENPWKQNPWFESVAVAQERARKRLPQPVYGALVAG
                     SERGQSASDNQGAFAEIGFQPVVAGQKAPADQTTTVWGHEISQPVVISPTGVQAVHPDG
                     EVAVARAAENRGTIMGLSNFASKSVEEVVATGARTMFQMYWTGERDVMVQRMQRAQDAG
                     AIGLIATTDWSFSMGRDWGSPEIPEKVDLKTMVRFAPKVVTKPRWLWTFGRTGMIPDLT
                     APNLAPPGAAKGPTFFGAYYEWMTTTPPSWDDISWMREQWAQISGGKPFVLKGVSRVDD
                     ARRAVDAGVAGISVSNHGGNNLDGTPAAIRMVKPIADRVGGEIDVVVDGGIRRGSDVVK
                     AVALGAKAVLIGRAYLWGLAANGEQGVGNVLDILRSGVDSTLRGMGVSSIHDVRPEHLL
                     VPEGFHRTLGDG"
     misc_feature    11235..11250
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.71"
                     /tool="antismash"
     gene            complement(11365..12681)
                     /gene="mftC"
                     /locus_tag="K329_RS0121095"
     CDS             complement(11365..12681)
                     /EC_number="1.3.98.7"
                     /EC_number="4.1.99.26"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008355690.1"
                     /locus_tag="K329_RS0121095"
                     /note="MftC is a radical SAM/SPASM enzyme that catalyzes
                     the first two steps in biosynthesis of the electron carrier
                     mycofactocin from the terminal Val-Tyr dipeptide of the
                     precursor peptide MftA.; MftC is a radical SAM/SPASM enzyme
                     that catalyzes the first two steps in biosynthesis of the
                     electron carrier mycofactocin from the terminal Val-Tyr
                     dipeptide of the precursor peptide MftA; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="mycofactocin radical SAM maturase"
                     /protein_id="WP_028474588.1"
                     /sec_met_domain="PTHR43273 (E-value: 5.9e-42, bitscore:
                     140.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 4.8e-24, bitscore: 81.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.1e-06, bitscore: 23.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3e-09, bitscore: 33.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2e-15, bitscore: 53.3,
                     seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.4e-06, bitscore: 24.3,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIAPERPTTAPAVPASRRPSTGRLVDEFELGLDAPICLTWELTY
                     ACNLECAHCLSSSGRRDPRELTTEQCKAVIDELQRMQVFYVNIGGGEPTIRPDFWELLQ
                     YAVDHQVGVKFSTNGVRLNPERARFLASTDYVDVQISLDGATAEVNDYVRGPGSYDTAI
                     TALKNLQEAGFKDAKISVVCTRQNIGQLDEFKALADTYGATLRLTRLRPSGRGADVWDE
                     LHPLPEQQRELYDWLMSHGENVLTGDSFFHLAAFGEALPGLNLCGAGRVVCLIDPIGDV
                     YACPFAIHDEFLAGNLLADGGFKQVWQQSELFQELRSPQTGGACSSCQFFDTCRGGCMA
                     AKFFTGLPLDGPDPECVQGYGESALAGDRSIPAASQDHSKKNPTRNAPVMLSIGRRPDD
                     LSSALTPRAAPVSACAESPLAGFDPAESSGGCASGACGC"
     gene            complement(12678..13052)
                     /gene="mftB"
                     /locus_tag="K329_RS28585"
     CDS             complement(12678..13052)
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: Mycofactocin_RRE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008355688.1"
                     /locus_tag="K329_RS28585"
                     /note="MftB, a small protein, is a peptide chaperone that
                     assists the radical SAM enzyme MftC in performing two
                     modifications to the C-terminal Val-Tyr dipeptide of the
                     mycofactocin precursor peptide, MftA. MftB's role is
                     analogous to the role of PqqD in the biosynthesis of PQQ, a
                     cofactor that derives entirely from a Tyr and a Glu in the
                     precursor PqqA.; MftB, a small protein, is a peptide
                     chaperone that assists the radical SAM enzyme MftC in
                     performing two modifications to the C-terminal Val-Tyr
                     dipeptide of the mycofactocin precursor peptide, MftA.
                     MftB's role is analogous to the role of PqqD in the
                     biosynthesis of PQQ, a cofactor that derives entirely from
                     a Tyr and a Glu in the precursor PqqA; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="mycofactocin biosynthesis chaperone MftB"
                     /protein_id="WP_084541485.1"
                     /sec_met_domain="Mycofactocin_RRE (E-value: 1.5e-27,
                     bitscore: 92.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDAPNDPTDAAAPAVPTAAPAVGLHEPWALSPAVALRPEPFGAL
                     AYHFGNRKLTFLKRPELVALVRALGEHDDVQGALAAAGIPDTQWEAFLGALSGLAVTDM
                     IRPRPAAPAVDGATREGNAA"
     aSDomain        complement(12738..12974)
                     /aSDomain="Mycofactocin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a mycofactocin
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_K329_RS28585_Mycofactocin_RRE.1"
                     /evalue="3.10E-29"
                     /identifier="RREFam016.1"
                     /label="K329_RS28585"
                     /locus_tag="K329_RS28585"
                     /protein_end="105"
                     /protein_start="26"
                     /score="92.0"
                     /tool="antismash"
                     /translation="EPWALSPAVALRPEPFGALAYHFGNRKLTFLKRPELVALVRALGE
                     HDDVQGALAAAGIPDTQWEAFLGALSGLAVTDMI"
     gene            complement(13093..13188)
                     /gene="mftA"
                     /locus_tag="K329_RS30520"
     CDS             complement(13093..13188)
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_process="GO:0140604 - mycofactocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mftA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008355686.1"
                     /locus_tag="K329_RS30520"
                     /note="Mycofactocin is a small molecule electron carrier
                     derived from the final two amino acids, Val-Tyr, of MftA,
                     the mycofactocin precursor. It plays a role in redox
                     homeostasis and the metabolism of alcohols and aldehydes in
                     Actinobacteria, including Mycobacterium tuberculosis;
                     Derived by automated computational analysis using gene
                     prediction method: Protein Homology."
                     /product="mycofactocin precursor MftA"
                     /protein_id="WP_084541486.1"
                     /transl_table=11
                     /translation="MTQPDETTETPELTAELLIEEVSIDGMCGVY"
     gene            13307..13906
                     /gene="mftR"
                     /locus_tag="K329_RS0121110"
     CDS             13307..13906
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0036042 - long-chain fatty acyl-CoA
                     binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene="mftR"
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017936749.1"
                     /locus_tag="K329_RS0121110"
                     /note="MftR, the mycofactocin system transcriptional
                     regulator, is an uncharacterized TetR family DNA-binding
                     transcription factor. Its role is inferred by context. It
                     occurs as part of the biosynthesis locus for mycofactocin,
                     a partially characterized electron carrier derived from the
                     terminal Val-Tyr dipeptide of the precursor peptide MftA,
                     through a radical SAM enzyme-mediated process; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="mycofactocin system transcriptional regulator"
                     /protein_id="WP_028474589.1"
                     /transl_table=11
                     /translation="MVHEPRPGVFGRPRTTTHDAIESRALDLFDERGFEQTTVDDVAAA
                     AGISRRTLFRYFSSKNDIPWGRFADGLAELERRLEASPTDVPLWRALHEAILDFNELPP
                     GAEVQHRRRMRLLLETPALQAHSALMYAEWRGVVQRFAARRYDVPADHVRAVVVGHAAL
                     AVSLAAYEAWLAQDDADLVEVLDEALAALREHLGAV"
     gene            complement(14201..14956)
                     /locus_tag="K329_RS0121115"
     CDS             complement(14201..14956)
                     /NRPS_PKS="Domain: PKS_KR (8-161). E-value: 9.6e-10. Score:
                     30.6. Matches aSDomain:
                     nrpspksdomains_K329_RS0121115_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012918705.1"
                     /locus_tag="K329_RS0121115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_028474590.1"
                     /transl_table=11
                     /translation="MQLAQTAAIVTGAASGLGAATAAALAAQGAEVFGLDLPGSIEDAP
                     SVDGVTYVGTDVTDPEQVAAAVATAAEGAPLRTVVSCAGIGPSARILGKKGPHDLALYA
                     KVVQINLVGTFNVLTLAAEQIAQTEPLEHGARGVVINTASIAAYDGQVGQAAYASSKGG
                     VVGLTLPAARDLAQHGIRVCTIAPGIVETPMLATVSDEFRAGLAAGVPFPQRLARPEEY
                     AQLALAIIDHDYLNGEVIRMDGALRMAPR"
     aSDomain        complement(14474..14932)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_K329_RS0121115_PKS_KR.1"
                     /evalue="9.60E-10"
                     /label="K329_RS0121115_PKS_KR.1"
                     /locus_tag="K329_RS0121115"
                     /protein_end="161"
                     /protein_start="8"
                     /score="30.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="IVTGAASGLGAATAAALAAQGAEVFGLDLPGSIEDAPSVDGVTYV
                     GTDVTDPEQVAAAVATAAEGAPLRTVVSCAGIGPSARILGKKGPHDLALYAKVVQINLV
                     GTFNVLTLAAEQIAQTEPLEHGARGVVINTASIAAYDGQVGQAAYASSK"
     CDS_motif       complement(14867..14932)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_K329_RS0121115_0001"
                     /evalue="6.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="K329_RS0121115"
                     /protein_end="30"
                     /protein_start="8"
                     /score="15.7"
                     /tool="antismash"
                     /translation="IVTGAASGLGAATAAALAAQGA"
     gene            complement(15012..16181)
                     /locus_tag="K329_RS0121120"
     CDS             complement(15012..16181)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011753737.1"
                     /locus_tag="K329_RS0121120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_028474591.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 3.1e-27, bitscore:
                     91.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.2e-27, bitscore:
                     90.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-46, bitscore:
                     154.4, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPARRLLPSEEAVDLIALVRDLATKELAPRAAEAEESAEFPRDVF
                     RLLGQTGILGLPYAEEHGGGGVPYEVYLQVLEELGRVWASVGVGVSVHALSCFGLVTKG
                     TEEQKKEWLPDMLGGDLLGAYCLSEAHAGSDPAAMRTTARRDGDHYVLNGAKAWTTHGG
                     QADFYKVMARTSDDRNGISCFLVPADTEGLVADNPERKMGLMGSTTATMVFENVRVPVE
                     RRLGEEGDGLRIALAGLDSGRLGIAAVATGLAQGALDASLAYAQQRTAFGKRIVDHQGL
                     GFVLADMEAAVQSARAVTLHAARLRDQGLPFGREASVAKLVATDNAMKVTTDGVQVLGG
                     VGYTRDFPLERYMREAKVMQIFEGTNQIQRMVIARSLDTSTQTGLELVR"
     gene            16295..16879
                     /locus_tag="K329_RS0121125"
     CDS             16295..16879
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012918703.1"
                     /locus_tag="K329_RS0121125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_028474592.1"
                     /transl_table=11
                     /translation="MARTTQRPRRTARQDALLDRLVTLFAAEGFARLTLDDIAARLSCS
                     KTTLYALASSKQELVVEAARQYFRVATAEVEAGLDGVEGCGPRIEAYLRGVAACLQPLS
                     PAFLEDLSGFAPAAAVYRRNTEAAADRIRQLVSAGVESGELRPVHAGFVGEMVAATMFE
                     IQRGRLFERLELTDAEAYAELATFVVTALTD"
     gene            17026..17205
                     /locus_tag="K329_RS0121130"
     CDS             17026..17205
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K329_RS0121130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_028474593.1"
                     /transl_table=11
                     /translation="MNRSTTASTLGWSTLVLAGATVVLVMTALLPSAAITAALAVACLT
                     GWDHLRRERRTTSV"
     gene            complement(17241..17534)
                     /locus_tag="K329_RS0121135"
     CDS             complement(17241..17534)
                     /EC_number="5.4.99.5"
                     /GO_process="GO:0046417 - chorismate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014847131.1"
                     /locus_tag="K329_RS0121135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chorismate mutase"
                     /protein_id="WP_245596635.1"
                     /transl_table=11
                     /translation="MTSDAPPELLRLRSSIDNIDAALVHLLAERFKCTQQVGVLKATQG
                     LPPADPAREERQIERLRDLALTAGLDPVFAEKFLNFVIAEVIHHHQRIAEDA"
     gene            17810..19351
                     /locus_tag="K329_RS28590"
     CDS             17810..19351
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013865920.1"
                     /locus_tag="K329_RS28590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MDR family MFS transporter"
                     /protein_id="WP_245596636.1"
                     /transl_table=11
                     /translation="MTDTRAEKSVPAGPATPPGTPGGGAADALDRRDVVVIAVLLVASF
                     VVILNETVMSVAIPVLQVELDIAPSVGQWLTTAFLLTMGVVIPLTGYLIQRLGTRPLFG
                     LAMSLFTAGTAIAFVAPGFEVLLVARIVQATGTAIMLPLLMTTVMTLVPPSRRGVMMGN
                     ISIVISVAPALGPTVSGVILDHFGWRWIFGLVLPIAVAALVIGLRMVRSVSPTSPARID
                     LVSVPLAVLGFGGLVYGLVGLGHSAEGGSHLPPWLPFLVGGVALVVFVTRQLALAREDR
                     ALLDLRVFSSYQFCVCMVAMLIAMAAMLGTLILVPYFAQTVLDYGPTQTGLITLPGGLL
                     MGLAGPIVGRVYDARGPRVLLVPGTIMVSGALWMLTLVDQETSMMWLLATNMLLCVGLA
                     ATFTPLMTAGLGAVPPPLYAHGSAVLGTFQQVAGAAGTALFVTVMTVVAARERDAGVAE
                     AAAITEGVHTAFLVGAFVSLLLVAVATLVRRPPAEPAGPGDPAVDPHGADATRVP"
     gene            19366..19803
                     /locus_tag="K329_RS0121145"
     CDS             19366..19803
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="K329_RS0121145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_028474595.1"
                     /transl_table=11
                     /translation="MDVTACIYSPDGALRLTPDAFLDAALRWWPEAVAVDVRRRVPRSR
                     RVGVRVGEVGRSSFQVRLSRDGTELVTDGDHVQQIWVALWARALVPYDAPGRVVLVNAD
                     ASEAALLTPGMTAAEVWSAWRGQTQEWQRFARGWLSGTLAG"
     misc_feature    complement(19941..19955)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    20931..20945
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 24.85"
                     /tool="antismash"
ORIGIN
        1 cgaccgccct ggcccgggag ggcgcgcgcg tggccctgct cggccgggac gtcgacgctc
       61 tcgccgccgc cgcggcgacg atcgacggcg cggtgaccgt caccgccgac accaccgacg
      121 acgcccaggt gcgtgcggcg gtcgacgagg cggcgacggc gctcggccgc ctggacgtcg
      181 tggtcaactg cgctgccccg cgggcgaccg gcccgaagca gcccggcctc gccgcgctgg
      241 acgacgacga cttcctccac cagctcgaca ccaaggcgct cggctacctg cgcgtcgtcc
      301 gggccgccct gccccacctc cgctccgccg gcgggggcgc gatcgtcaac gtcagcggca
      361 tgaacgcccg catgacctcg aacatcaccg gctcggtgcg caacatcgcg gtcgtcgccc
      421 tcaccaagaa cctcgccgac gagctgggcg ccgagggcat ctccgtgtcg tgcgtgcacc
      481 ccgggctcac ggtcaccgag cgcaccgagg gcgacgaggc gtacgccgcc aaggccgccg
      541 ccggcaacgc cctcggccga ccggtcaccg ccgccgaggt ggccgaggtg atcacgttcc
      601 tcgcctcgcc ccgcggccgg atcaccaacg gggcggtcgt gacggccgac ggcggccggc
      661 cgggtccgat ctggacctga ccgaccgccg tcgggtctcg agacgctcgc tgcgctcgct
      721 cctcgaccac cgaggtcgag ggtggggctc aggcctccgc gtcgagggcg gcggccacgc
      781 ggcggtgggc ctcccagatc gcctcgggca gaccgtcgaa ctgctgcagg tgctcctcgc
      841 ggaacccgat ctcctggcgc cagcgctcgt tgtcgatgtt caggatgcgc tcgaggtcct
      901 cggcgggcag gtcgaggcca tcgaggttga gctcctcggc ggtcgggatg atgccgaccg
      961 gggtctggcg accggtgacc tcgccgttct tgagctgcat cagccacagc agcgggcgca
     1021 ggttctcgcg gtagccgggc cacaggaagt ggccgtcctc ggcgtcgcgc tggaaccagt
     1081 tcacgtgcgc gaagatcggc tgctcgctgg ccgcgccgac gatgttcagc cagtgctcgg
     1141 cgtacttcgc ctcgtcgtac gacatgaacg gccgcatcga catggggtcg tagcgcagct
     1201 gcccgtcgag cccgtcggcc gcgaaggtgg cctcggcgcc gagcgtcagc ccgtcgtaca
     1261 caccctcggc gaggtcgtgg atggcgcgca cgagcggctc gcggtcacgg gtgcggccac
     1321 cgaagatgat cgcgtcgatc ggcacgccgg ccggctcctc gaagtcggcc gccacgttgg
     1381 gcacgttggc gagcgtcgtc gtgaagcggc tgttcgggtg ggcccacggc gcgtcgacgc
     1441 cctcggcccg ctcggcgatc gactcgccct tccagtcggt ccagccgtcg aggtcggtcg
     1501 ggtgctcggg cgtcttgccc tcccaccaga cctcctgcgt cgtcgtgttg taggcgatgt
     1561 tcgtgaacag cgcgcccgtg ccctcggcga tggagtgcag cgccgtgggg ttggtgagct
     1621 cgttggtgtc cttcgcgacg ccgaacacgc cgaactcggg gttcatgccg tagagccggc
     1681 cgtcctcgcc gacccacagc cacgcgatgt cgtcgccgta gaactcgacg tggtagcggt
     1741 cgccgagggc gtccggggcc agcgtcatcg cgaggttcgt cttgcccgag gcgctcggga
     1801 agccgccgca gatgtggtac ttgcggcccg tctccttgtc gacgatgccc agcagcatga
     1861 actgctcggc gaggaacttc ttcgaggccc acccgtcgta cgccgcctgc cgcaggccgt
     1921 gggcgatctt gccgagcagc gcgttgccgc cgtagctcga gccgaagtgg aggatggtgc
     1981 gctcgtcggc gaccgtcacg aagtagcgct ggtcgtcggg ggtgccctgg cccaggttcg
     2041 gcaggtcgcc cgtgacgtgc acggcgcgca cgaagctgtt cgggtcctcg agcgcgtcga
     2101 tgtggtgcgc gccgacgcgg gccatccgga tcatgtggag cacgaccgtg cgggtgtccg
     2161 tgagctcgac gccggcggcg tacgcctcga gcggcgagcc gggcggcgcc atcaggtacg
     2221 ggatcacgta catcgtcttg ccggcggagg cgccgcgcat cttcgacgtc agcagctcct
     2281 tcatctcgtc ggcggggcgc cagttgttgt agacgccctt gtcggcgggg ttgctcgtcg
     2341 cgacgatggt gcgctcctcg gagcgcgccg tgtccttctg gtagctgcgg gagtagtaga
     2401 gaccgtcacc ggcgggctcg agctcgccgg cctcgacggc ctcggcgagc aggcgggcgt
     2461 cgtcggacgc gttgacgacc tcgacccgct cggcgccggt cacctccgcc cagtaggcca
     2521 cgtactcgcg cacgtgcggg ttcttcagac cggctgcgtc gagcgccgcc tccacattcg
     2581 ccatgatctc ccggatcctc tccgtcggca cgctgcgtga gcgtgcgggg gtcgatgtgc
     2641 gcctgatggt cgcacagtga cgtgggccac gggcggcggc ctcacgggcc gggacccctg
     2701 aacgatcggt cgggttcccg ttttgccacg gggcgccggt gcgccccaga gtcgctgtcg
     2761 tgaccgagat ccaggtggtg ccgcactccc cgttcgagaa catgttcggc gtgctcacgg
     2821 gcacgttcgt cgcgtcgttc ggcctggtgc tgctcaccga ggcgcaggcc gtcacgggtg
     2881 gtacggcggg cctcgccctc ctcgccagct acgggctgcc gatgtcgttc gggctgctct
     2941 tcctgctggt gaacgtgccc ttcttcgccc tggcgctcaa ggtcaagggc tggcagttca
     3001 cgctgcgcac gctcgtctgc gtcggcctgg tgagcgccat gagcgccctg cacgagtcga
     3061 tgctcgacat cgaccgcatc tccgcgccgt acgccgcggt cggcggcaac ctcatcgccg
     3121 gcatcggcct gctcatcgtc ttccgccacg gggccagcct cggcggcttc aacatcgtgg
     3181 cgctcgtcgc gcaggagcgc ctcggctggc gcgcgggcta cgtgcagatg gtgctcgacg
     3241 tgctcgtggt cgtcggtgcc ctcaccgtgg tggcgcccca gaacgtgctg ctctcggccg
     3301 tcggcgcggt cgtgctcaac ctggtgctcg cgctcaacca ccggccgggc cgctacaccg
     3361 gggcctgagc cccggaggtc ggtcgagccc ggccgcgcca gggcggtgac ctcgcgcccg
     3421 ctcaggccgg tggcgcgggg gcggcggctc agcgggccag gaggagccgc accacctgcg
     3481 tcgtcgtggc ggtgacggcg gcgacggcgc cggtgctcat ctcggacagc tcctggggtc
     3541 cgttggcgat cgagaacgcc gccgtgatgc cggcgtcggc gagcgtggcc gcgtcgacct
     3601 gcaccgaccc ggcgaccacc acgacgggta cggcgggggg cgtgaggccg cggacggtgt
     3661 cgacgacctt gccgccgaac gactgggagt cgaggcggcc ctccccggtg agcacgaggt
     3721 cgacgccgtc gaggagcgcc gggaggccca gggtgtcggc gacgagcagg ccgccggggg
     3781 cgatctcggc cccgaggagc gcggtgagcg cggcgggcat gccgccggcg gcgcccgcgc
     3841 cgggcaggtc gcggacctcg acaccggtgt gatcggcgag cacgtcggcg aggcgggaga
     3901 gaccggcgtc caggacctcg acgtcggcgg gggtggcgcc cttctgcggc ccgaagaccg
     3961 cggcggcccc gcgctcaccg acgagcgggt tcgtgacgtc gcaggcgatc cgccaccgcg
     4021 ccgcggcggc ccgcgggtcg aggccggacg tgtcgagcgt ggcgaggtcg cgcaggtggc
     4081 cgccgccgtc gggcagctcg gtgccgtcgg cggcgaggaa gcgcacgccg agggcgcgca
     4141 gcattcccgt gccgccgtca gtggtggcgg acccgccgat gcacagcagc acgtcggtgc
     4201 agcccgcgtc gagcaccgcc cgggccagga cgccgacacc gtgggtgctc gcggcgagcg
     4261 gctgcagcgg tacgtcgctc acgcgcggca gcccgttggc ctcggcggcc tcgacgatcg
     4321 cggacgtgcc gtcgggcgag acgccgtagc gggcggtggt cggccggccg agcgcgtcgg
     4381 tcgtggcggt cgtgcgggcg tcggtgcccc aggcgccgag cagggcgtcg agggtgccct
     4441 ccccgccgtc cgcgaagggc agcgtgcgga tctcgagccc gacgccggac gacgacgccg
     4501 cgtcgcggac gccggcggcc atggcctcgg cgacctcgct cgcgctcgcg ctccccttga
     4561 acgagtcggg gacgatcgcg acgcgcagcg agcggtggcg ctgctctgcg gtgggcatgc
     4621 cgacgacctt aggatgacgg ccgtcacacc ggctacggcg aaccgcacat acctgcggcg
     4681 ctccggacct cgttcaggtg tgcgttctgc cctcgtcgcc gtcggcggcc acggcgtcgt
     4741 acgccatcgt ggcgctgcgc aggacggcgg cgtcgtcggc gcgacggagg tccagccccg
     4801 tgagggtgcg gatgcgctcc acgcgctgca gcagcgtgtt gcggtgcacg aagagcagcg
     4861 cggcgccggc cgagagcgag ggggcgcggg tcacggcgcg caccgtctcg cggtggacgg
     4921 gagcgagccg ggcggcggtg cgcgccagcc ggcggcgcgt gctgtcgggc aggtgggcca
     4981 cggtgacggc gaggtcggcg ttccaggtcg cccggtcggc ggcgtgcggc aggagccgcg
     5041 ccaggcggcc gagggcgcgg aggtcgtggg cccaggaggc gagctcgtcg acgtcgtcga
     5101 gggcgtccac caccacggcc cgggtgccgg ccccgcccag cgacgggtcg agccggcgcc
     5161 cgccggaggt gacgacccag agcaggccgt gcagcacgat ggcgcaggtg gccccggcgg
     5221 gtgcggacga cccggggcgc gcgtccgcgc gccggtcgtt cgtggtcgtg acgaggtgct
     5281 cggcgtggcg cggcggggtc gcggagccgt cctggtgggg cacggtggcc gcccacaccc
     5341 cgatcgacca gggcccgacg cccaggccgg tggcggcgag ccgctcgcgc acggccggcg
     5401 ccgacgcggt cgacgagcac agcgtcgcca cgagctcgcg ggccagggtg cgggtgaggt
     5461 ggtcgctgtc gtgctcgcgc tcctgggtga tgagcagctg gatggtgagg gcgacgacgt
     5521 gggcgagctg ctcgacctgc tccgggtcgc cggtgacccc gacgaccccg gccagctcgc
     5581 cgtcgacctc gagcggcacg ttgatgccgg gccggtcgac cacgccctcg acgacctggg
     5641 tgaccgcgac cggccgaccc gtcgagagca cgcggcgggc ggcgcggtgc ggtcggccga
     5701 tgcggtcggc cacggtcgac gcgatgacgg tgccgtgcgc gtccatgagg ttgaggtcct
     5761 ggcggatcgt cgaggcgacg acgtcgacca cgcgctgacc gatctgcgcg tcgagcgagc
     5821 cgggccccgg gagggggccg gggtcgtcgg gtcgcgctcc ggcctcgtcg ccgggtcctg
     5881 cgtcggccag catgccgggc agcgtacgac gacgggcccg gacgacacga ggtcgtccgg
     5941 gcccgtcggg gtggtgctgc gcgggaggtg gtgcgtcagg ccagcggcac gcggccgaag
     6001 taggccgacg tcgaccagat gcgctccttc ttcacgctct cgccggagcc gggggcgtgc
     6061 cacacctggt tgttcccggc gtagatcgcg acgtggtaga cgcggccgcc gttgtggaag
     6121 aagacgaggt cgccggggcg gacctgcgag gcggtgacgc gcacgacggc gccgagctgc
     6181 tggctcgacg tgcggggcag gctcttgccg gccttggcgt agacgtagct ggtgaagccg
     6241 gagcagtcga agccgctgct cgggttggtg ccgccgtagc ggtacggcgt gccctggagg
     6301 gactgggcgt tcttcagcac cttccagttg cggtagtcgt agtgccgcat gaactccgcc
     6361 tgggccgcgg ccttggagga ggtcgtggag gcggccgcgc tggccggggc ggtggtggcc
     6421 ccgacgctca tggcggcggt ggagacgacg gccgcgacgg ccaggccggt ggccgtgacg
     6481 gtgcgacgca gggagccggc ctcggggcgg gctccggtgc tggtggtgcc ggtggtcggg
     6541 ctgctcgtcg agcgggcgag cacacgggct cgtccctcgg cgcggtgcag gggctggtgg
     6601 aggccggcgc ggctgggcgc aggcacggtg gactcactgt gcatgggggg tccttgcggc
     6661 gtcgcctccg aaagatgacc tgtcgggttc gggctgccgt tgcccgggcc tgcgcgcatc
     6721 gctgcgtcgc cgaccttcac ccctagccgc tccccgagga acggcgtact gcctgggtct
     6781 cccgtgctcg ccactcgcgc tctacgcggt catgttctcc ccagaccgtg gcaagcctcg
     6841 gcgcagatct gggcggcccc gccggttccg gcgaggactt cagccgtcaa ctgtgggtgg
     6901 acccacccac tttggcaact cctagaacct tcaacttttg tgcaatatgt cacccgtgta
     6961 acggcgccca cgcgccgccg gcccgccgcg acggcgtcgg gagggccccg cgccgtaggg
     7021 tcggggcatg gaaccgctcg agacgtcggc gtggcgcgag tacggcgcgc ccgacctgcc
     7081 gcgggtgctg ctcgcggccc tcgacgcctt cgccgagcag ggctaccacg gcacctcgat
     7141 ccgtgagctg gcctcccggg cgcagctgtc ggtgccgggg ctctaccacc actacagctc
     7201 gaagcaggac atcctcgtcg acctgctcga ggccgtgatg cgggaggtca tcgaccgcag
     7261 cgaggccgcg ctcgccgccg ccgcgccgga cagcctgagc cgcttcgacg cgctcgtgga
     7321 gtgcgtgctg cggttccaca tgttccgcaa ccagggcgcg ttcgtgacct cgagcgagct
     7381 gcgcagcctc acgccggcca accgcgccac gatcgtcggg ctgcgcgacc accagcagca
     7441 gctcatcgac cgggccgtcg acgccggggt cgccgacggg acgttcgcga cgccgtaccc
     7501 caaggccgcc agccgcgccg tcaccgtgct ctgcacgggg gtggcctcct ggtaccgcgc
     7561 cgacggcgag ctgtcgcccg acgagctcgt ccggcgccac ctcgtgctcg cgcacggcct
     7621 cgtcggggtg cagggtcggg ccgcgggcct caccgtcgtg ccggccgagg gtccctgacc
     7681 cccacgggtg ccgccgaacc gacctcgacc cgtgtaacgc ggtgtccacg tgactgcaca
     7741 cgtgttccta cgcgtgtgca gtggctcgga caccgcgtta cacgggggtg gtgggggaga
     7801 gacccccacc gaggacgccc cctcaggggg ccagggcgcg cagccacagg tcggcgtacc
     7861 gctccccgag ctgctcgggg ctgtaggtgc cgccctcgtc gaaccaccgc cacgggccgt
     7921 tcgcggtgtc gatgatcgcg ttcatgacgg cggtgtcggt gggggcgagg gtgccgtcgg
     7981 cggcgccggt gtcgagcgcc tggtgccaca gcgcgtcgac ccggtcgagc acctcgcgca
     8041 gctcggcggc ccgctcgggg gcgaggtggt cgaggtcgcg gatggtgatc gcctgctggt
     8101 ggcggtagcg gatgacggag acgacgtggg tgcggatgag gccccgcagg cgctcggccc
     8161 cggtgccctc cgcgacggcc tgctcggcga ccgcgagcac gtcgctgacg tactgcgtca
     8221 ccaccatgta gagcagctcc tgcttggtgc tgatgtggta gtagagcgca ccccgcttga
     8281 cctgcacgag ctcctcgatg tcggagaggc tcgtggcggc gtagcccttc gtcgcgaaca
     8341 gcgcgacggc ggcgcggagg atccggtcac gggtcgagag gcccgcgagg gactcggggt
     8401 cgagcccggg cagggtggag acagccatgc ggttcctcgt ctggagcgag ccggtgccgc
     8461 ggatcgcgcg tccggtctgg cccgagtgta ggagaccgac cgatcggtca gatgccgaag
     8521 ccgccgtcgg ccgagaccac cgagccgtgc agcgcggcgc ccgcgggcga gcagcaggcc
     8581 gcgaccacgt cggcgatctc ggcgggctcc aggggtcggc gcaggccctg gtggcgggcc
     8641 agctcggcga tgccctcctc cccgctcagc ccgtagaggg ccgcggtggc ggtgagcatc
     8701 ggggtgcggg tggcgccggg cgagaccgcg accgcggtga ccccggtgcc gaccaggtcg
     8761 gccgcgaggc ctcgcacgat gccgatgacg gcgtgcttga cggtcgtgta cgccgacagc
     8821 gagaacaggc catgctcccc ggcggccgac gcgatcgcca cgaaccgggc gaggtgcggc
     8881 tccggcccgg cgagcaggtg gggcacggtg acggcggcgg tggtccagac gcccttggcg
     8941 tcgacctccc agagctcgtc gagcacctct ggcggggtct cccacagcgg ggcgccgccc
     9001 ccgacgacgg ccgcggcggc gaccacggcg tccaggcggc cgcgtcgcgc gacgacgtcg
     9061 gcggcgagcg cggccagcgc cggggcgtcc cgcacgtcca cgacgtgcga ctccaccgcc
     9121 ggtcccgtca cgggcgcgac gtcgacgccc acgacgtcgt agccgtcccg ggccagcgcg
     9181 gcgagcgtcg ccgtgccgat gccgcccgcg gctcccgtca cgagcgccac gcgccgcccg
     9241 ctcacccgcc cgctcccccg accgccccgg accgctccgg gtggacggcc gcggggtgca
     9301 gcaggccgcg ttcgtcgggc aggccgtggc gtacggcgtg gagcacgtcc cgcacgatgc
     9361 ccgcgaccag cacgcgcccg tgctccgcgg tggcgcccgt cgggtcgccc agcacgccgt
     9421 tcggcgagac cgccctcacg ccgccgctca tcagggtcgg gaggatctcg gagagggcgt
     9481 cggtgcagcc ggcctcggcc cgccgtacgt cgacgtcggc gggccgcagg tggagcatga
     9541 tcgaggtctc cgtgagcccg gcgtggaggt cgacctcctc ggtcgcgcac gccacccagg
     9601 ccgcgtcgtg accctccgcc cgcagccgcg tcaccgccgc ggtgagggcg aagacgttgc
     9661 cgccgtgggc gttgacgaag accatccggt cggcccacag ctgcgccgag cgcaccagct
     9721 cgacgaggag cgtggtgagc acctcggtgc cgatcgagag ggtgcccggg aacccgtggt
     9781 gctcgccgct cgcgccgtac acgatcggcg gcgccacgag caccggcacc tcgtcggcga
     9841 ggtgcacggc gacccggctc gcgacctcgc cggcgatgac ggagtcggtg tcgaggggca
     9901 ggtgcggccc gtgctgctcg atcgacccca ccggcaccag gagcaggccg cccgtctcga
     9961 cgtcgggcca ggagcggggc gtgagggcgg ggaccacggg tcagccgtcc ccgagggtgc
    10021 ggtggaaccc ctccggcaca agcaggtgct cggggcgcac gtcgtggatg ctggacaccc
    10081 ccatgccgcg cagggtcgag tcgacgcccg atcggaggat gtcgagcacg ttgccgacgc
    10141 cctgctcgcc gttggcggcg aggccccaga ggtaggcgcg gccgatgagc acggccttcg
    10201 cgcccagcgc gaccgccttc acgacgtcgg acccccgccg gatgccgccg tcgacgacca
    10261 cgtcgatctc gccgcccacg cggtcggcga tcggcttcac catccggatg gcggcggggg
    10321 tgccgtcgag gttgttgccg ccgtggttgc tcaccgagat gcccgcgacg cccgcgtcga
    10381 cggcccggcg cgcgtcgtcg acccggctga cgcccttgag cacgaacggc ttgccgcccg
    10441 agatctgcgc ccactgctcg cgcatccacg agatgtcgtc ccacgacggg ggcgtcgtgg
    10501 tcatccactc gtagtaggcg ccgaagaacg tggggccctt cgctgccccg ggaggcgcca
    10561 ggttgggggc ggtgaggtcg gggatcatgc cggtcctccc gaacgtccac agccagcgcg
    10621 gcttggtgac gaccttcggc gcgaaccgca ccatcgtctt caggtcgacc ttctcgggga
    10681 tctccgggga gccccagtcg cggcccatcg agaacgacca gtcggtggtg gcgatgaggc
    10741 cgatcgcgcc ggcgtcctgc gcccgctgca tgcgctggac catcacgtcg cgctcgccgg
    10801 tccagtacat ctggaacatc gtgcgggcgc cggtggccac gacctcctcc accgacttcg
    10861 aggcgaagtt cgacagtccc atgatcgtgc cgcggttctc ggcggcccgg gcgacggcga
    10921 cctcgccgtc ggggtgcacc gcctgcacgc cggtcgggct gatcacgacg ggctgggaga
    10981 tctcgtggcc ccagaccgtg gtcgtctggt cggccggggc cttctggccc gccacgacgg
    11041 gctggaaccc gatctcggcg aaggcgccct ggttgtcgct cgccgactgc ccgcgctccg
    11101 agccggcgac gagcgcgccg tacacgggct gcgggagccg cttgcgcgcc cgctcctgcg
    11161 cgacggcgac ggactcgaac caggggttct gcttccaggg gttctcgacc ttggagagcc
    11221 actcgggctg ggccatgacg cttccttcac tggtacggcg gcgcgcgcac gggtgcggcg
    11281 cgggtggggc gggagaggtg gtggcccggc gggcgcacgt acggcgattc cgcacgcccg
    11341 ccgggcgatc gtgggggcgg cgcctcagca gccgcaggcg cccgaggcgc agccgccgga
    11401 gctctcggcc gggtcgaagc cggccagggg gctctcggcg caggccgaca cgggcgcggc
    11461 ccgcggggtg agcgccgacg agaggtcgtc gggccggcgc ccgatcgaca gcatgaccgg
    11521 ggcgttgcgg gtcgggttct tcttcgagtg gtcctggctc gccgccggga tgctgcggtc
    11581 gcccgcgagg gccgactcgc cgtacccctg cacgcactcg gggtcgggcc cgtcgagcgg
    11641 gagcccggtg aagaacttgg cggccatgca gccgccgcgg caggtgtcga agaactggca
    11701 cgacgagcag gcgccgccgg tctggggcga gcgcagctcc tggaagagct cggactgctg
    11761 ccagacctgc ttgaagccgc cgtcggcgag caggttgccg gcgaggaact cgtcgtggat
    11821 cgcgaacggg cacgcgtaga cgtcgccgat cgggtcgatg aggcagacca cgcggcccgc
    11881 gccgcagagg ttgaggcccg ggagcgcctc gccgaacgcg gcgaggtgga agaaggagtc
    11941 gccggtcagc acgttctcgc cgtggctcat cagccagtcg tagagctcgc gctgctgctc
    12001 ggggagcggg tgcagctcgt cccacacgtc ggcgccacgg ccgctggggc gcaggcgggt
    12061 gaggcgcagg gtcgcgccgt acgtgtcggc cagggccttg aactcgtcga gctggccgat
    12121 gttctggcgc gtgcagacga cggagatctt cgcgtccttg aagcccgcct cctggaggtt
    12181 cttcagggcc gtgatcgcgg tgtcgtagga gccgggcccg cgcacgtagt cgttgacctc
    12241 ggcggtcgcg ccgtcgaggg agatctgcac gtcgacgtag tcggtgctcg cgaggaagcg
    12301 ggcgcgctcc gggttgagcc gcacgccgtt cgtggagaac ttcacgccga cctggtggtc
    12361 gacggcgtac tgcagcagct cccagaagtc ggggcggatc gtcggctcgc cgccgccgat
    12421 gttcacgtag aagacctgca tgcgctgcag ctcgtcgatg acggccttgc actgctcggt
    12481 cgtcagctcg cgggggtcgc ggcggcccga cgacgacagg cagtgggcgc actcgaggtt
    12541 gcaggcgtag gtgagctccc acgtcaggca gatcggggcg tcgaggccga gctcgaactc
    12601 gtcgaccagg cggcccgtgc tggggcggcg ggaggccggg acggccggcg cggtggtggg
    12661 ccgctcgggg gcgatcgtca tgcggcgttc ccttctcggg tggcgccgtc gaccgcggga
    12721 gcggccgggc gcggacggat catgtcggtg acggcgagac cgctcagcgc gccgaggaag
    12781 gcctcccact gcgtgtcggg gatgccggcg gcggcgagcg cgccctgcac gtcgtcgtgc
    12841 tcgccgagcg cccgcacgag ggcgacgagc tcgggacgct tgaggaacgt cagcttgcgg
    12901 ttgccgaagt ggtaggcgag cgccccgaac ggctcgggcc gcagcgcgac cgcgggcgac
    12961 agcgcccacg gctcgtggag gccgacggca ggtgccgcgg tcggtacggc gggggccgcc
    13021 gcgtcggtcg ggtcgttcgg ggcgtcgctc atgtccaggg ctcctgggtc gctcggatgg
    13081 tgggcgagcg gctcagtaga cgccgcacat gccgtcgatg gagacctctt cgatgaggag
    13141 ctcggcggtg agctcggggg tctcggtcgt ctcgtcgggc tgggtcatga cgggtctcct
    13201 tcacaggggg tggacgggtc gatgtgctgt gcgccacatt aatgacaccc ggtgccggat
    13261 gggaagaggt gccccgcgga actgcccgat cggagaggat gcgcagatgg tccacgagcc
    13321 gcgccccggg gtcttcggtc gcccgcgcac cacgacgcac gacgccatcg agtcgcgtgc
    13381 gctggacctc ttcgacgagc gcggcttcga gcagaccacc gtcgacgacg tcgcggccgc
    13441 cgcgggcatc agccgccgca cgctcttccg ctacttctcg tccaagaacg acatcccgtg
    13501 gggccggttc gccgacggcc tcgccgagct cgagcggcgc ctggaggcgt cgcccacgga
    13561 cgtgccgctc tggcgcgcgc tccacgaggc gatcctcgac ttcaacgagc tgccgcccgg
    13621 cgccgaggtg cagcaccgcc ggcgcatgcg gctgctcctc gagacgccgg cgctgcaggc
    13681 gcactccgcg ctcatgtacg ccgagtggcg cggcgtcgtg cagcggttcg cggcccgtcg
    13741 gtacgacgtc ccggccgacc acgtgcgcgc cgtcgtcgtc ggccacgcgg ccctcgcggt
    13801 gtcgctcgcg gcctacgagg cctggctcgc ccaggacgac gccgacctcg tcgaggtgct
    13861 cgacgaggcc ctcgcggcgt tgcgggagca cctcggagcg gtctgagcgc gctcggggcc
    13921 ggtgccggcg gcggccgggc ccgacaggat gagcccgacc gcctgatcgg gagccgggac
    13981 ctccgccggc gaggtcgggg gcgccgaccc ggcggcggag gtggctccgg gaccagcggc
    14041 accgtcgtgc cgctgtcggt gagtcatccg ttgcccccgt ggtgtcggat tggtcacagc
    14101 gccgactttc tcgaggtcgt cgcacgacgc agcgagcccg gccacccacg gtggccgggc
    14161 tcgcgtcgta ccgcaggagc ggtgggcgga ggaggggtcg tcagcgcggc gccatgcgca
    14221 gcgcgccgtc catgcggatg acctcgccgt tcaggtagtc gtggtcgatg atcgcgagcg
    14281 ccagctgggc gtactcctcg ggccgcgcga ggcgctgcgg gaagggcacg cccgccgcga
    14341 ggccggcgcg gaactcgtcg gagacggtgg cgagcatcgg ggtctcgacg atgccgggcg
    14401 cgatcgtgca gacgcggatg ccgtgctgcg ccaggtcgcg ggcggccggg agcgtgaggc
    14461 cgacgacgcc acccttcgag gaggcgtagg ccgcctggcc gacctgcccg tcgtacgccg
    14521 cgatgctggc ggtgttgatg accacgccgc gggcgccgtg ctcgagcggc tcggtctgtg
    14581 cgatctgctc ggctgcgagc gtcagcacgt tgaacgtgcc gacgaggttg atctgcacga
    14641 ccttggcgta gagcgcgagg tcgtgcggac ccttcttgcc gaggatgcgc gccgacgggc
    14701 cgatgccggc gcagctgacg accgtgcgca gcggcgcgcc ctcggcggcg gtcgcgacgg
    14761 ccgccgcgac ctgctcgggg tcggtgacgt cggtgccgac gtaggtcacg ccgtcgacgc
    14821 tcggggcgtc ctcgatcgag ccgggcaggt cgaggccgaa gacctcggcc ccctgcgcgg
    14881 cgagggcggc ggcggtggcg gcgccgagtc cggaggccgc gccggtgacg atcgcggcgg
    14941 tctgggcgag ctgcatgggt tctcctgggg gtgaggcggg cgtacggcgg gcggacggcg
    15001 ggggagcggc gtcagcggac gagctcgagg cccgtctggg tcgaggtgtc gagcgagcgg
    15061 gcgatgacca tgcgctggat ctggttggtg ccctcgaaga tctgcatgac cttggcctcg
    15121 cgcatgtagc gctcgagcgg gaagtcgcgg gtgtagccga cgccgccgag cacctggacg
    15181 ccgtcggtgg tgaccttcat ggcgttgtcg gtggcgacga gcttggcgac gctggcctcg
    15241 cggccgaacg gcaggccctg gtcgcgcagg cgggccgcgt gcagggtcac ggcgcgggcg
    15301 gactgcaccg ccgcctccat gtcggcgagc acgaacccga ggccctggtg gtcgacgatc
    15361 cgcttgccga acgcggtgcg ctgctgggcg taggcgaggg aggcgtcgag cgcgccctgg
    15421 gcgagaccgg tggcgacggc ggcgatgccg agacgaccgg agtcgaggcc ggcgagcgcg
    15481 atgcgcaggc cgtcgccctc ctcgccgagg cggcgctcga ccggcacgcg gacgttctcg
    15541 aacaccatgg tggccgtcgt cgaccccatg aggcccatct tgcgctcggg gttgtcggcg
    15601 acgaggccct cggtgtcggc cggcacgagg aagcaggaga tgccgttgcg gtcgtcggag
    15661 gtgcgggcca tgaccttgta gaagtcggcc tgcccgccgt gcgtcgtcca cgccttcgcg
    15721 ccgttgagca cgtagtggtc gccgtcgcgc cgcgcggtcg tgcgcatcgc ggccgggtcg
    15781 gagccggcgt gcgcctcgga gaggcagtag gcgccgagca ggtcgccgcc gagcatgtcg
    15841 ggcagccact ccttcttctg ctcctcggtg cccttggtga cgaggccgaa gcaggagagt
    15901 gcgtgcaccg agacgccgac gccgacgctc gcccacacgc ggccgagctc ctcgagcacc
    15961 tgcaggtaga cctcgtacgg caccccgccg ccgccgtgct cctcggcgta cggaaggccg
    16021 aggatcccgg tctggccgag gaggcggaag acgtcgcgcg ggaactccgc gctctcctcg
    16081 gcctcggcgg cccggggggc cagctccttg gtcgcgaggt cgcggacgag ggcgatgagg
    16141 tcgacggcct cctcgctggg cagcaggcgg cgtgcgggca cgggaactcc tcggatcgcg
    16201 gggcgggtcg tcccgaacga tactggacga cgttctgcag tatcgtctcc ggtactggtc
    16261 gcggtgtcga ccctacgacg acgaaagggt ggcgatggcc cgcacgacgc aacgtccccg
    16321 ccgtacggcg cgccaggacg ccctgctcga ccggctcgtc acgctgttcg ccgccgaggg
    16381 gttcgcccgc ctcaccctcg acgacatcgc cgcccggctc agctgctcga agacgacgct
    16441 ctacgcgctg gcgtcgtcga agcaggagct cgtggtcgag gcggcgcgcc agtacttccg
    16501 cgtcgcgacc gccgaggtcg aggcgggtct ggacggggtc gagggctgcg gtccgcggat
    16561 cgaggcctac ctgcgcggcg tggccgcctg cctgcagccg ttgtcgcccg cgttcctcga
    16621 ggacctctcg ggcttcgcgc ccgccgcggc cgtctaccgc cgcaacaccg aggccgccgc
    16681 cgaccgcatc cggcagctgg tcagcgcggg tgtcgagtcg ggcgagctgc gcccggtgca
    16741 cgccgggttc gtcggcgaga tggtcgccgc cacgatgttc gagatccagc ggggccggct
    16801 cttcgagcgc ctcgagctca cggacgccga ggcctacgcc gagctcgcca ccttcgtggt
    16861 cacggcgctg acggactgag cggggcgcgg gcctccgccc cgagacggag atcggcgcgg
    16921 tgggactccg tccccggacg gtggcccgag ccgcgctcgg gcaggagggt gggaaggaac
    16981 cgatccgtcc ccggcccgcc gtggccgtcc tgaggagtga cccgcatgaa ccgctcgacg
    17041 accgcctcga cgctcggctg gagcacgctg gtgctggccg gcgccaccgt cgtgctcgtg
    17101 atgaccgccc tgctgccgtc ggctgcgatc accgcggcgc tggccgtcgc ctgcctgacg
    17161 ggctgggacc acctgcgccg agagcgtcgt acgacgtcgg tctgaccggc ccgccctcga
    17221 ggcgctccga cgggctcggg tcaggcgtcc tcggcgatcc gctggtggtg gtggatcacc
    17281 tcggcgatga cgaagttgag gaacttctcg gcgaacaccg ggtcgagccc ggcggtcagg
    17341 gcgaggtcgc ggagccgctc gatctggcgc tcctcgcggg ccgggtcggc cggcggcagc
    17401 ccctgcgtcg ccttgagcac gccgacctgc tgggtgcact tgaaccgctc cgcgagcagg
    17461 tggacgagcg ctgcgtcgat gttgtcgatg ctggagcgca ggcggaggag ctcgggcggc
    17521 gcgtcggagg tcacgccgct caggatagga gcgcacggtc cgacgcccca ccccgcgtcc
    17581 acgggtggtg gggcgggcgt cgtacgcgcc ggcgggtccg ggtgcatccc gggtccaggg
    17641 ccgtcccgtg tcccgggtca ccgcgaaagc cggtggctgc gcgtcgatga cttctggcac
    17701 cctcgggggt cgacacccca gtgagccaac gacccggtgt cccccggccg gccgcgcccg
    17761 tcgcgcggca ccacggccga ccgtccgacg tacccccgag gagcaccacg tgaccgacac
    17821 ccgcgccgag aagtccgtgc ccgcgggccc ggccacgccg ccgggcacgc ccgggggcgg
    17881 tgccgcggac gccctggacc gccgcgacgt cgtcgtgatc gccgtgctgc tggtcgccag
    17941 cttcgtcgtc atcctgaacg agaccgtcat gagcgtggcg atccccgtgc tgcaggtcga
    18001 gctcgacatc gcgccgagcg tcgggcagtg gctgaccacg gcgttcctgc tcacgatggg
    18061 cgtggtcatc ccgctcaccg gctacctgat ccagcggctc ggcacgcgtc ccctcttcgg
    18121 gctcgccatg agcctcttca ccgcgggcac ggcgatcgcg ttcgtggcgc ccggcttcga
    18181 ggtgctgctg gtcgcgcgca tcgtgcaggc gaccggcacg gcgatcatgc tgccgctgct
    18241 catgaccacg gtgatgacgc tcgtgccgcc gtcgcgccgc ggcgtgatga tgggcaacat
    18301 ctcgatcgtc atctcggtgg cgcccgcgct cggcccgacg gtgtccggcg tgatcctcga
    18361 ccacttcggc tggcgctgga tcttcggcct cgtgctgccc atcgcggtcg ccgcgctggt
    18421 gatcggcctg cggatggtgc gctcggtctc gcccacgtcc ccggcgcgga tcgacctcgt
    18481 ctcggtgccg ctcgcggtgc tcggcttcgg cggcctcgtc tacggcctcg tcgggctcgg
    18541 ccactccgcc gagggcggct cgcacctccc gccgtggctg ccgttcctcg tcggcggcgt
    18601 cgccctcgtc gtgttcgtga cgcgtcagct ggccctggcc cgcgaggacc gcgcgctgct
    18661 cgacctgcgg gtgttctcgt cgtaccagtt ctgcgtctgc atggtcgcga tgctcatcgc
    18721 gatggccgcg atgctgggca cgctcatcct ggtgccctac ttcgcgcaga ccgtgctcga
    18781 ctacgggccc acccagacgg gtctgatcac gctgcccggc ggcctgctga tggggctggc
    18841 gggcccgatc gtggggcgcg tgtacgacgc ccgcggcccc cgcgtgctgc tggtgccggg
    18901 cacgatcatg gtgagcggag cgctctggat gctgaccctg gtcgaccagg agacgtcgat
    18961 gatgtggctg ctcgccacca acatgctgct ctgcgtcggc ctggccgcga ccttcacgcc
    19021 gctcatgacg gccggcctgg gcgcggtgcc gccgccgctc tacgcgcacg gctcggcggt
    19081 gctcggcacg ttccagcagg tcgcgggcgc ggcgggcacg gccctcttcg tcaccgtgat
    19141 gacggtcgtc gccgcccgcg agcgggacgc cggggtggcc gaggccgccg ccatcaccga
    19201 gggcgtgcac accgcgttcc tggtgggcgc gttcgtctcg ctgctgctgg tcgcggtggc
    19261 gacgctggtg cggcggccgc ccgcggagcc tgccggtccc ggcgatccgg ccgtcgaccc
    19321 gcacggcgcc gacgcgacac gcgtgccctg acgcacactg gtcgcgtgga cgtgaccgcg
    19381 tgcatctact cgcccgacgg cgcgctccgg ctgacgccgg acgcgttcct cgacgccgcc
    19441 ctccggtggt ggcccgaggc cgtcgcggtc gacgtgcgac gccgcgtgcc gcgctcgcgc
    19501 cgggtcgggg tccgggtggg cgaggtcggg cggtcgtcgt tccaggtccg gctctcgcgc
    19561 gacggcaccg agctggtcac cgacggcgac cacgtgcagc agatctgggt ggcgctctgg
    19621 gcgcgggcgc tggtgccgta cgacgccccg ggccgcgtcg tgctcgtcaa cgccgacgcg
    19681 agcgaggccg cgctgctgac gcccggcatg accgccgcgg aggtctggtc ggcctggcgc
    19741 gggcagacgc aggagtggca gcggttcgcc cgcgggtggc tctcggggac cttggcgggc
    19801 tgagcgggct gcgggtcctc cgacgggtcg tccggggctg tccacaggcc ccgagggtcg
    19861 cgcgaccggg ctgtcggacg ggcgtggcag gctctcccgc gtgtccctga cgatccaccg
    19921 tgcgccccgc accgacctcc tggccgacgg tctcggcgag ctgctcgcgc agccgctcga
    19981 cgacccgttc gccaccgagg tggtcgtggt gcccgcgcgc ggcgtggagc ggtgggtcac
    20041 gcagcggctc tcgcaccggc tcggcgccgg tccgcggggc ggcgacggcg tgtgcgcggg
    20101 cgtccggttc ctcaccccca cctccctcgt cgccctgctc ctggggcgcg agcgcgacga
    20161 cccgtgggag gcgtcccgcc tggtctggcc cgtgctcgac gccgtcgacg cccacctcga
    20221 cgaggcctgg tgcgctccgc tggcccgtca cctcggccgc ctgctggcgc ccggcgaggg
    20281 cgccgacgtg gccgagctgc gccggtcgcg ccgctggtcg gtggcgcgac ggctcgcggg
    20341 gctcttcgcg tcgtacgccg cccagcggcc gcagctggtc gccgactggc gcgcgggtcg
    20401 cgacctcgac ggtgccggcg tgccgctgcc cgacgacctg cgctggcagg cggagctgtg
    20461 gcgccgggtg ctcgagcgcg tcgatgcgcc gccgcccgac gagcggctga ccgcgacgct
    20521 ggcggcgctc cgggcgggcg gggaggggct cgacctcccc gctcggctct ccctcttcgg
    20581 ccacacccgg ctgccggcct ccgaggtggc gctcctcgag gcgctcgcgc agacccggga
    20641 ggtgcacctc tggctgccgg tcgcgtcgcc cgccctggcc gcggcgctcg accgggccgg
    20701 ctcgtcggag gcccgctcgt cggagggcgg ggccgtcctc cgccgcgccg acgacacctc
    20761 cgccggcctc gtgcaccacc cgttgctcgc ctcgctgggg cgcgacgccc gcgagctgca
    20821 ccacgccctc gccgcggtgc cgggcgcgga ggtcgtcgac ctcgccgcgc ccgcggacga
    20881 cggcgccgag accgacggca cgctgctggc gctgctgcag gccgacatcc gggccgaccg
    20941 gtcccccgac cgcgcgctgc gggccgagcg cacccgcgcc tccgacccgt cggtgcaggt
    21001 gcacgcctgc cacggtccgg cccgccaggt cgaggtgctg cgcgaggtgc tcgtcggcct
    21061 cctcgccgac gaccccaccc tcgagccccg cgacgtgctc gtcatgtgtc ccgacgtcga
    21121 gacctacgca ccgctggtgc aggccgggtt cggcctgtcg gtggcggggg tccccgggga
    21181 gccggcgggc ccggtcgacg gccaccaccc ggcccaccag ctgcgggtgc gcctcgccga
    21241 ccgctcgccg ggcagcgtca acccgctgct cgccctcgcg acccgcctgc tggagatggc
    21301 gggcggccgg gccacggcgt ccgaggtgct cgacctggcg gccctgccgg cggtgcgccg
    21361 ccggttcggg ctcgacgacg acgcgctggc gcgggtggag cgctgggtgc aggacagcgg
    21421 cgtgcgctgg ggcctcgacc ccgcccaccg ggcggagtac gggctgggcg gcgtcgccca
    21481 gaacacctgg cgtgcgggcc tcgaccgcgt gctgctgggc gtcgcgatgg ccggtgacga
    21541 gccccgctgg gtcggcagcg cgctgccgct cgacgacgtc ggcagcagcg acatcgagct
    21601 ggccggccag ctcgccgagc tcgtcgaccg gctcgacacc ggcctgcgca gcctccacgg
    21661 gcccgcgccc gcctcggtct ggacgaccac gctggcggcc accgtcgccg ccctcaccgc
    21721 cgtgcccgcc accgaggcgt ggcaggtcac cgagctcgag cgcgagctcg cccgcgcgac
    21781 gccggtcgac gccgcggggc tcggcccgga cgccgagctg acgctgcccg acgtgcgcgc
    21841 gatgctggcg cggcagctgg gcggtcggcc cacgcgctcc aacttccgca ccggcaccct
    21901 caccgtcgcc accctcgtgc cgatgcgctc ggtcccgcac cgcgtcgtct gcctgctcgg
    21961 gctcgacgac ggcgtcttcc cccgctctgg catcgtcgac ggcgacgacg tgctcgcccg
    22021 ctcgccgctc gtcggcgagc gcgacgcccg cagcgaggac cggcagctgc tcctcgacgc
    22081 cgtcatggcc gccaccgaga cgctcgtcgt cacctacacc ggggccggcg agcacacggg
    22141 cggcctccgc ccgcccgcgg tgccgctggg cgagctggtc accgcggtcc gccgcacggc
    22201 cgacgtgcag cgcgacgtcg tggtgcgcca ccccctgcag ccgttcgacc cggcgaacct
    22261 gacggtgggt gccgtggagg agacccgccc gctgaccccg gccggcgcgc ccccgctcag
    22321 cttcgacacc gccgcgctcg agggggcgct ggcggcccgc gggccccgca cgccggcggg
    22381 ccccctcgtg accgcgccgc tgcgcgaccg tcccgagacg accgtcgccc tcgacgacct
    22441 ggtgcgcttc ctggtgcacc cggcgcgcga cttcctgcgc agccggctcg acgtgagcgt
    22501 cccgttcgac gtcgacgagg tcgacgacgc gatcccggtc gacctcgacg gcctcgcgaa
    22561 gtggggggtc ggccaccggc tgctcaccga cgcgctcgcg ggcatcgagc cggccgacgc
    22621 gatcgcggcc gagcggcgcc gtggcctgct gcccccgcgg gcgctcggcg agaccgtgct
    22681 cgagcgcgtc aagggcgacg tgcgcgacct ccacctcggc accgcgtcgc tgcgggtcgg
    22741 cgagccccgc acgctcgacg tcgacgtcga cctcggcggg gtccggctgg tgggcacggt
    22801 cggcaacgtc cacggcaacc ggctcgtgtc cgtcggcttc tcgtccctgc gggccaccca
    22861 ccggctgacg gcgtgggtgc ggctgctggc gctgacggcg tcgtaccccg acgagagctt
    22921 caccgcccac acggtcggca aggggcgggg ggcgccgcag cgctcgatcg ccgggccgct
    22981 cgaccaccgg gcggtcgact ggctccgggc gctcgtcgac gtccgcgcgc ggggcctgcg
    23041 cgagccgctg cc
//
