GCF_000424045.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_KE384124.1 (Streptococcus equinus B315 (Streptococcus bovis B315))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	furan	420,156	441,064
Region 1.2	lanthipeptide-class-i	636,162	662,187	High	suicin 90-1330	ribosomal:RiPP
Region 1.3	T3PKS	790,291	831,469

NZ_AUJD01000004.1 (Streptococcus equinus B315 (Streptococcus bovis B315))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	terpene-precursor	73,556	94,425	Low	macedocin	ribosomal:RiPP:Lanthipeptide

NZ_AUJD01000005.1 (Streptococcus equinus B315 (Streptococcus bovis B315))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	arylpolyene	47,689	89,881

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	furan	420,156	441,064
Region 1.2	lanthipeptide-class-i	636,162	662,187	High	suicin 90-1330	ribosomal:RiPP
Region 1.3	T3PKS	790,291	831,469
Region 2.1	terpene-precursor	73,556	94,425	Low	macedocin	ribosomal:RiPP:Lanthipeptide
Region 3.1	arylpolyene	47,689	89,881

No secondary metabolite regions were found in these records:: NZ_AUJD01000006.1 (Streptococcus equinus B315 (Streptococcus bovis B315)); NZ_AUJD01000007.1 (Streptococcus equinus B315 (Streptococcus bovis B315)); NZ_AUJD01000008.1 (Streptococcus equinus B315 (Streptococcus bovis B315)); NZ_AUJD01000009.1 (Streptococcus equinus B315 (Streptococcus bovis B315)); NZ_KE384125.1 (Streptococcus equinus B315 (Streptococcus bovis B315)); NZ_AUJD01000012.1 (Streptococcus equinus B315 (Streptococcus bovis B315))

Compact view

NZ_KE384124.1 - Region 1 - furan

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Location: 420,156 - 441,064 nt. (total: 20,909 nt) Show pHMM detection rules used

furan: (mmyO or AvrD)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

G597_RS0105625: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000500.5	0.39	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002382.3	0.39	ribosomal	grimoviridin	Grimontia marina
BGC0001788.3	0.37	ribosomal	suicin 65	Streptococcus suis
BGC0001525.3	0.37	other (other)	bartoloside B, bartoloside C, bartoloside D	Synechocystis salina LEGE 06155
BGC0001526.4	0.37	other (other)	bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K	Synechocystis salina LEGE 06099
BGC0000526.5	0.37	ribosomal	macedocin	Streptococcus macedonicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.40	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001862.4	0.40	ribosomal	pallidocin	Aeribacillus pallidus
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000500.5	0.39	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002382.3	0.39	ribosomal	grimoviridin	Grimontia marina
BGC0001788.3	0.37	ribosomal	suicin 65	Streptococcus suis
BGC0001525.3	0.37	other (other)	bartoloside B, bartoloside C, bartoloside D	Synechocystis salina LEGE 06155
BGC0001526.4	0.37	other (other)	bartoloside E, bartoloside F, bartoloside G, bartoloside H, bartoloside I, bartoloside J, bartoloside K	Synechocystis salina LEGE 06099
BGC0000526.5	0.37	ribosomal	macedocin	Streptococcus macedonicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.81 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.14 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.49 out of 28.19

Confidence: medium

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.37 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.55 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_KE384124.1 - Region 2 - lanthipeptide-class-i

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Location: 636,162 - 662,187 nt. (total: 26,026 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase protease

G597_RS0106685: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

G597_RS08845: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Lyases: cyclase dehydratase

G597_RS0106720: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

G597_RS0106730: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

G597_RS0106750: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.73	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.73	ribosomal	nisin U	Streptococcus uberis
BGC0000538.3	0.69	ribosomal	nisin Z	Lactococcus lactis
BGC0000506.4	0.59	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001289.5	0.58	ribosomal	penisin	Paenibacillus ehimensis
BGC0000559.4	0.57	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000556.5	0.54	ribosomal	streptin	Streptococcus pyogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.73	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.73	ribosomal	nisin U	Streptococcus uberis
BGC0000538.3	0.69	ribosomal	nisin Z	Lactococcus lactis
BGC0000506.4	0.59	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0001289.5	0.58	ribosomal	penisin	Paenibacillus ehimensis
BGC0000559.4	0.57	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000556.5	0.54	ribosomal	streptin	Streptococcus pyogenes

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for G597_RS0106720

G597_RS0106700

Leader:

MSNEDFNLDLVSVSKNSNSGASPR

Core:

ITSKSLCTPGCKTGALMTCPIKTATCGCHFGN

Core with dehydrations:

IDhbDhaKDhaLCysDhbPGCysKDhbGALMDhbCysPIKDhbADhbCysGCysHFGN

antiSMASH-DB 4.0 matches for G597_RS0106700

100.0%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHFGN

87.5%

NC_015600.1and 14 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHFG

+TSKSLCTPGCKTG LMTC IKTATCGCHFG

VTSKSLCTPGCKTGILMTCAIKTATCGCHFG

87.5%

NZ_JAMDIB010000004.1:

Lanthipeptides: M5P35_RS04030_lanthipeptide

ITSKSLCTP-GCKTGALMTCPIKTATCGCHFG

+TSKSLCTP GCKTG LMTC IKTATCGCHFG

VTSKSLCTPPGCKTGILMTCAIKTATCGCHFG

with 119 more sequence matches

Only the first 10 are displayed here.

81.2%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

+TS SLCTPGCKTG LMTC IKTATCGCHF

VTSISLCTPGCKTGILMTCAIKTATCGCHF

72.7%

NZ_CP015405.2and 7 others:

NZ_CP015405.2 Lanthipeptides: A4V09_RS08295_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08290_lanthipeptideNZ_CP015405.2 Lanthipeptides: A4V09_RS08285_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06240_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06235_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06230_lanthipeptideNZ_CP053228.1 Lanthipeptides: HL650_RS06225_lanthipeptide

Lanthipeptides: A4V09_RS08300_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

ITSKSLCTPGC TG LMTCP++TATCGC

ITSKSLCTPGCVTGILMTCPVQTATCGCQI

70.6%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

ITS SLCTPGCKTGALM C +KTA+CGCH

ITSYSLCTPGCKTGALMGCTMKTASCGCHV

70.6%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

ITS SLCTPGCKTGALM C +KTA+CGCH

ITSVSLCTPGCKTGALMGCNMKTASCGCHV

69.7%

NZ_JADNJR010000016.1and 2 others:

NZ_JADNJR010000016.1 Lanthipeptides: I2E58_RS10875_lanthipeptideNZ_QSHK01000002.1 Lanthipeptides: DW860_RS04740_lanthipeptide

Lanthipeptides: I2E58_RS10880_lanthipeptide

SKSLCTPGCKTGALMTCPIKTATCGCHF

SKS CTPGC TG LMTCP+KTATCGCH

SKSACTPGCPTGILMTCPLKTATCGCHI

69.7%

NZ_QSHK01000002.1and 1 other:

NZ_QSHK01000002.1 Lanthipeptides: DW860_RS04730_lanthipeptide

Lanthipeptides: DW860_RS04735_lanthipeptide

SKSLCTPGCKTGALMTCPIKTATCGCHF

SKS+CTPGC TG LMTCP+KTATCGCH

SKSVCTPGCPTGILMTCPLKTATCGCHI

69.4%

NZ_NHVL01000013.1:

Lanthipeptides: CEU70_RS16825_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGC--HFGN

+TSKSLCTPGCKTG L TC IK+ATCGC H G

VTSKSLCTPGCKTGILQTCAIKSATCGCSIHIGK

68.6%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGC--HFG

ITSKSLCTPGC TG LM C KTATC C H G

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHVG

67.6%

NC_013656.1and 20 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

ITS SLCTPGCKTGALM C +KTATC C

ITSISLCTPGCKTGALMGCNMKTATCNCSI

67.6%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSKSLCTPGCKTGALMTCPIKTATCGC

ITS SLCTPGCKTGALM C +KTATC C

ITSISLCTPGCKTGALMGCNMKTATCHC

MIBiG 4.0 matches for G597_RS0106700

67.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSKSLCTPGCKTGALMTCPIKTATCGC

ITS SLCTPGCKTGALM C +KTATC C

ITSISLCTPGCKTGALMGCNMKTATCHC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.14 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.23 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.16 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.10 out of 39.62

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.19 out of 32.74

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

G597_RS0106700 - Class I

Cleavage pHMM score: 27.20

RODEO score: 28

Monoisotopic mass: 3099.5 Da

Molecular weight: 3101.7 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3119.7 Da N = 1; 3137.7 Da N = 2; 3155.8 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 140 - 226; Score: 37.3

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_KE384124.1 - Region 3 - T3PKS

Download region GenBank file

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Location: 790,291 - 831,469 nt. (total: 41,179 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

G597_RS0107445: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

G597_RS0107510: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Isomerases: isomerase

G597_RS0107605: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

G597_RS0107515: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease

G597_RS0107545: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.44	other (other)	amphotericin B	Streptomyces nodosus
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000883.5	0.41	other (other)	arginomycin	Streptomyces arginensis
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0001789.3	0.40	ribosomal	suicin 90-1330	Streptococcus suis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002561.3	0.45	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000016.4	0.44	other (other)	amphotericin B	Streptomyces nodosus
BGC0002707.2	0.41	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001080.5	0.41	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000934.4	0.41	other (phenazine)	5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G	Kitasatospora sp. HKI 714
BGC0000883.5	0.41	other (other)	arginomycin	Streptomyces arginensis
BGC0002031.3	0.41	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0001789.3	0.40	ribosomal	suicin 90-1330	Streptococcus suis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.69 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.73 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.58 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.52 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 28.19

Confidence: medium

Additional weak hits (5):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.12 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.47 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.41 out of 30.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_AUJD01000004.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 73,556 - 94,425 nt. (total: 20,870 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

G597_RS0100430: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	0.51	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.50	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000539.5	0.49	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001788.3	0.47	ribosomal	suicin 65	Streptococcus suis
BGC0000526.5	0.46	ribosomal	macedocin	Streptococcus macedonicus
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000547.5	0.51	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000557.5	0.50	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000539.5	0.49	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001788.3	0.47	ribosomal	suicin 65	Streptococcus suis
BGC0000526.5	0.46	ribosomal	macedocin	Streptococcus macedonicus
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

G597_RS0100430: PT_FPPS_like

Domain 1 (25 - 280): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.99 out of 32.93

Confidence: medium

Additional weak hits (2):

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.38 out of 29.51

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
LexA variant 3	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_AUJD01000005.1 - Region 1 - arylpolyene

Download region GenBank file

Download region SVG

Location: 47,689 - 89,881 nt. (total: 42,193 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

G597_RS0101440: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: phosphotransferase

G597_RS0101565: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Ligases: synthase

G597_RS0101395: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

G597_RS0101475: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000107.3	0.56	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0002510.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001987.2	0.45	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000243.4	0.44	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000107.3	0.56	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0002510.2	0.48	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001987.2	0.45	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000243.4	0.44	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.09 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06

Confidence: medium

Additional weak hits (4):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.68 out of 26.85

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.51 out of 30.98

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.70 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.47 out of 28.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

G597_RS0101435: pk

PKS_AT (85..218): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes