LOCUS       NZ_KE384124            26026 bp    DNA     linear   CON 16-JAN-2024
DEFINITION  Streptococcus equinus B315 G597DRAFT_scaffold00001.1, whole genome
            shotgun sequence.
ACCESSION   NZ_KE384124
VERSION     NZ_KE384124.1
KEYWORDS    WGS; IMPROVED_HIGH_QUALITY_DRAFT; RefSeq.
SOURCE      Streptococcus equinus B315 (Streptococcus bovis B315)
  ORGANISM  Streptococcus equinus B315
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1069377)
  AUTHORS   Kelly,W., Huntemann,M., Han,J., Chen,A., Kyrpides,N., Mavromatis,K.,
            Markowitz,V., Palaniappan,K., Ivanova,N., Schaumberg,A., Pati,A.,
            Liolios,K., Nordberg,H.P., Cantor,M.N., Hua,S.X. and Woyke,T.
  CONSRTM   DOE Joint Genome Institute
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUL-2013) DOE Joint Genome Institute, 2800 Mitchell
            Drive, Walnut Creek, CA 94598-1698, USA
COMMENT     ##MIGS-Data-START##
            investigation_type                :: bacteria_archaea
            project_name                      :: Streptococcus bovis B315
            sequencing_meth                   :: WGS
            GOLD Stamp ID                     :: Gi22249
            Gram Staining                     :: Gram+
            ##MIGS-Data-END##
            ##Genome-Assembly-Data-START##
            Finishing Goal                    :: Improved High-Quality Draft
            Current Finishing Status          :: Improved High-Quality Draft
            Assembly Method :: Unknown program v. before 2013-05-07
            Genome Coverage                   :: Unknown
            Sequencing Technology             :: Illumina HiSeq 2000
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/16/2024 00:48:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,736
            CDSs (total)                      :: 1,697
            Genes (coding)                    :: 1,681
            CDSs (with protein)               :: 1,681
            Genes (RNA)                       :: 39
            rRNAs                             :: 2, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 31
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 16
            CDSs (without protein)            :: 16
            Pseudo Genes (ambiguous residues) :: 1 of 16
            Pseudo Genes (frameshifted)       :: 5 of 16
            Pseudo Genes (incomplete)         :: 8 of 16
            Pseudo Genes (internal stop)      :: 4 of 16
            Pseudo Genes (multiple problems)  :: 2 of 16
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 18:02:13
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 636161
            Orig. end                         :: 662187
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KE384124.1.
            URL -- http://www.jgi.doe.gov
            JGI Project ID: 1012737
            Source DNA and Organism available from William   Kelly
            (bill.kelly@agresearch.co.nz)
            Source DNA available from William   Kelly
            (bill.kelly@agresearch.co.nz)
            Organism available from William   Kelly
            (bill.kelly@agresearch.co.nz)
            Contacts: William   Kelly (bill.kelly@agresearch.co.nz)
            Tanja Woyke (microbe@cuba.jgi-psf.org)
            Whole genome sequencing and draft assembly at JGI-PGF
            Annotation by JGI-ORNL
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376)
            Full annotations are available from IMG.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26026
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26026
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26026
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16026](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16026
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            11..499
                     /locus_tag="G597_RS08840"
     CDS             11..499
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="G597_RS08840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_049805818.1"
                     /transl_table=11
                     /translation="MVNIKSEAEKLAIANKFLVTSERLFAKYGYLGVSLSEVAKESGVS
                     KGTLFNYFTNKETLFMCLLLRGYQQYFEIPFEKLSSLPNLSDAELLDFFEKETRYLIQN
                     KITLLRLNALRAPILERKADKNQTIEGRKVLNNKIKLVGELLAQKVSGMSADSIAHLF"
     gene            642..2423
                     /gene="lepA"
                     /locus_tag="G597_RS08845"
                     /pseudo=""
     CDS             642..2423
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="lepA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002822646.1"
                     /locus_tag="G597_RS08845"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="translation elongation factor 4"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNYKKEVKLMQDRIRNFAIIAHIDHGKSTLADRIMEMTDMVSLRD
                     STDQQVDNLSVEKAHGVTVKSCTVRNCYHAKDGQDYIYQLIDTPGHVDFSYEVEKSLTA
                     CEGVLLLVDATQGIQAQTLANYQIAKATGLTILPIINKVDGPNADVEKVAREIQNLDNT
                     LSKPLLISAKTGQGVSEVLEAIHLVIPAPKGKIDELLKALVFDSFYDSYKELSL"
     gene            complement(2604..2876)
                     /locus_tag="G597_RS08850"
     CDS             complement(2604..2876)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G597_RS08850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_049805819.1"
                     /transl_table=11
                     /translation="MRAKEVIKLVANSVLNEICLYLIMEESTILIENIVEQLSDEDLEH
                     FIYPNNWAYDLFDDIDVYTLLYSWFYLNTDNSYHFSHWLGNKFYA"
     misc_feature    2915..2930
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.16"
                     /tool="antismash"
     gene            complement(3013..3285)
                     /locus_tag="G597_RS08855"
     CDS             complement(3013..3285)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="G597_RS08855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_024343834.1"
                     /transl_table=11
                     /translation="MPKTSFKNNENIAQSIKQRHIELGLTIEEAAKKTAIGTKTWSRYE
                     SGNPIRKDKLDSIIRTLKWQEIPPELDSKNSSLETILSKYKKHEA"
     misc_feature    complement(3236..3256)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 25.1"
                     /tool="antismash"
     misc_feature    complement(3505..3523)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.19"
                     /tool="antismash"
     gene            3732..4982
                     /locus_tag="G597_RS0106685"
     CDS             3732..4982
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014636301.1"
                     /locus_tag="G597_RS0106685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="S8 family serine peptidase"
                     /protein_id="WP_234702510.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 9.8e-37, bitscore:
                     122.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDNESIKIVTENFQSQGINIIDEVPEINLILISTDKNPETLKLE
                     NNSYIDGMVKENETTVKPEISYWFGERQYTNDESDFWLNQWDMQKSTQTGEKFTHKSSG
                     NSVVGVIDSGIDYSNSEISSSIISAQNFTTDSEGNVDSGNIADKIGHGTSVVGQISSNG
                     KYLGIAPNMRVRMYRVFDEENAQDLWILRAIIQAANDDVDVLNLSLGEYLINASNCKDY
                     DSVLIEAYQRAINYAHNQGTAIVASVGDEGLDLTNQEQLKSYIGSLNGDNYKENDGQVK
                     DIPAELDNVVTVGSIGDSDRVSSFSNKGNGIIDIYATGGGSERLLLTGYEEWLDKKLYE
                     KDFVLVPTLEGKYTYEYGTSLSAPKVSATLGLIIEKYHLKDKPDEAIKILYNTCSRLCN
                     DATGAQFRVLDITNLVR"
     gene            5011..5694
                     /locus_tag="G597_RS0106690"
     CDS             5011..5694
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012677617.1"
                     /locus_tag="G597_RS0106690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_024343836.1"
                     /transl_table=11
                     /translation="MYKILVVDDDFEILKLMRTILEMKNYDVTTYQGITLPLNSKDFQG
                     FDLILLDVMMPDIDGLQVCRQIRDKVSAPIIFVSAKDEEDDIVTGLNLGGDDYITKPFS
                     VKQLVAKVAAHLKREERFRQAESDEKIIRELLPITFYLQEKTVCVNGNIVPLTSREYDL
                     LDLLSANRNKVFTREDIYSHIYDDEADALFRSISEYVYQIRVKFSAYDINPIKTVRGMG
                     YKWYD"
     gene            5687..7027
                     /locus_tag="G597_RS0106695"
     CDS             5687..7027
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000977994.1"
                     /locus_tag="G597_RS0106695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_027968568.1"
                     /transl_table=11
                     /translation="MTKQYSIKRRVLRCVSEIVIGTVLNVFVLFLLSYVLAMTGQLNSY
                     GSDFKVDIKDSASAEKIAKRLNQTTFDYILFEKSSGKISSGKYQREDYGCYRAAFNHAR
                     SEDFGTIRYAKFSNSNYVLIVRCPTLPEFVNPRLRYLSFNNFSYLFFLILELILVIWSV
                     SRLLKEFTKNFRLIQEISMNMGQPEVAIKRSQTEMTEFNDILSMLYQKDAELVALLQAE
                     RKAKKDLSFQVAALAHDIKTPLTVLKGNLELLEMTGLTKEQLEFLTSANNSIQTFEKYF
                     NDMIHYSRLLVEEKNYQEEICLSEFLEELTTEAKAIMDAQGAEFGVTKRVNSEFFKGNQ
                     LNLSRALINILSNAARYSSGHKKVTLSVIEKEDFLTFTVWNNGPAFTKEALESADNLFY
                     TENKGRSNKHYGIGLSFAQAVAKKHHGKLVLQNPPTGGATVSLSIKK"
     gene            7439..7609
                     /locus_tag="G597_RS0106700"
     CDS             7439..7609
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_a"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058290.1"
                     /locus_tag="G597_RS0106700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_024343838.1"
                     /sec_met_domain="TIGR03731 (E-value: 6.2e-22, bitscore:
                     73.3, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_a (E-value: 2.3e-06, bitscore:
                     22.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNEDFNLDLVSVSKNSNSGASPRITSKSLCTPGCKTGALMTCPI
                     KTATCGCHFGN"
     CDS_motif       7439..7510
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSNEDFNLDLVSVSKNSNSGASPR"
                     /locus_tag="G597_RS0106700_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7511..7609
                     /prepeptide="core"
                     /locus_tag="G597_RS0106700_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="27.20"
                     /molecular_weight="3101.7"
                     /monoisotopic_mass="3099.5"
                     /core_sequence="ITSKSLCTPGCKTGALMTCPIKTATCGCHFGN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSNEDFNLDLVSVSKNSNSGASPR"
                     /leader_location="[7438:7510](+)"
                     /alternative_weights="3119.7"
                     /alternative_weights="3137.7"
                     /alternative_weights="3155.8"
     gene            7724..8416
                     /locus_tag="G597_RS0106705"
     CDS             7724..8416
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014623198.1"
                     /locus_tag="G597_RS0106705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_024343839.1"
                     /transl_table=11
                     /translation="MVVQVKNLKKSFKDKEILKGISFEIEKGSVCGLLGVNGAGKSTIM
                     KIIFGLEEADSGAVVFNGEQISEKSSADFNIGALIESPAIYMNLSAFDNLKTRALLYDI
                     SDVRIKEVLKLIGLSHTGKKKAGHFSLGMKQRLGLGMAMITNPDLLILDEPTNGLDPDG
                     IKELLDLISHLKNTGMTILLSSHQLHEVSKVADHIVILHDGEIFYDEANTHDADLEKLF
                     FKIVHGGA"
     gene            8418..9152
                     /locus_tag="G597_RS0106710"
     CDS             8418..9152
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013851902.1"
                     /locus_tag="G597_RS0106710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic ABC transporter permease"
                     /protein_id="WP_024343840.1"
                     /transl_table=11
                     /translation="MKKILKSEWLKQKSSSDKKLLFFVPFLTIFIAVLLSGYSLLESFS
                     VYWWEAIFLYTLIGLLFLYDYKAEEKAGHFQNIHLGKDTFKIYLAKMLLKVKDIFVATV
                     IFTVIFYLVSLLFSGVMSVNIGKDFLCLLLIMLASIWNLPFLYFLSKWLSPYLLLAGNS
                     LICLLVAPFLAQIPIWYVFPYTYHYKIAYGMMRLKPSGDLDVARVVDVQLIVTALVLSF
                     LMCLLFIFLLKWRENSDELSKK"
     gene            9133..9783
                     /locus_tag="G597_RS0106715"
     CDS             9133..9783
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018380134.1"
                     /locus_tag="G597_RS0106715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic transporter"
                     /protein_id="WP_024343841.1"
                     /transl_table=11
                     /translation="MNYLKSELLKWKNSYACYLILVLSVLQLVTILPYVLLVNNPTILE
                     NLIFIYMLGYCIVMSVMSILLHEQEMDANHFQNIRSEKCRLTIWTMKLVAADLVVMVPT
                     FLLWLAVGVEVNNISHFAYAGLIICLLLVMLNHFHMFLSLFMGKGGNLLISFVECLFIV
                     FATNKAFLNVLWMPIALPVNLIFTYTVTSLLALLGYIILFYFGNLVMLSRMKF"
     gene            10001..12982
                     /locus_tag="G597_RS0106720"
     CDS             10001..12982
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000400478.1"
                     /locus_tag="G597_RS0106720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_024343842.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3e-89, bitscore:
                     295.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.8e-10,
                     bitscore: 37.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-23, bitscore:
                     79.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKYNADSFLVRNTITEEKSLQFYDYVTFLNYVKEDKKFQEQLF
                     VASRSLYDSLQKYYNNTPMKKKKIRQMSESIYKYYKRSIDRSTPFGLFSKTSVGEFSDE
                     NQLILNSKAKKSILFDLEWLTSLVFKIEKKYYRKLYFKLNAANYRYGNRVVQIYSINNN
                     ETEELNIKFTKVYQIIQKSCLEKYVSFNQILNSILKVYGLEYKSLAENYIVSLIENHFL
                     LSNLNYDLVSDFDRKKFISEVKKVDEEDAFYSTLCKIVRLIDEYSILQIGEGIGKLEYI
                     YGLMSSLVKTNNFLQIDLHDTGHAKLNFSLKKQIVEFSEFLSNLSTSVQKSYLDNFKDL
                     FLEKYGLYREVQLVELFDSNMGLGAPYGYTHPQNYCYESTPKTIFYSETEEKMYLNELE
                     LSLESGKSIQLNKFKRYYKNLQGNVNKVNQGFELFFNINYENNDCILSLGSAGCSKNLG
                     ASSGRFSVISDELKEYHRDNAKVIEDLNSDLGYNTCEIVFLPENLRHANVMRTDNIRQK
                     TLSLFTYNRGEQIKLSDIYIGIDAQNNFYAKECKSGKLVKFYSTNMYNQLLFSNELRFL
                     CEISLDNHFGMFPWEIIFQKFSYVPRIVYGNLIVAPARWRLSGDDIDDDIEHIITKHNL
                     PLEFYVDNQDNRILINQSNHLDKELFASIIRKAKLKNEEVNLSECISAISLLNKKNKRY
                     AADIVVPVKCSDRSQFKVENIEMPEAISISERQKLPFEDWLYLKLYMSSDRQEEFLSDV
                     MPSIFNLVKEKGGKAFYIRYTDPKFHIRLRIKGQDLYSIYTKIQKILQKSIDNNLISTV
                     DISTYDREIERYGGCQKIDLVEDIFCIDTEVVINALSLLRTQKIHLTVEELAIVLNYFY
                     LKVVFKNQNDKIIHFLENVCPKHTVNKNSEKHKNMSLVQDYVNNCQIFEILPNLHELAQ
                     KVKKLSYNCKDFLEDYQYAIYDSIIHVHNNRLIGIDREKEEVIYDIIRGLVISEEFRNG
                     MSNG"
     aSDomain        10421..10678
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_G597_RS0106720_Lanthipeptide_LanB_RRE
                     .1"
                     /evalue="5.00E-12"
                     /identifier="RREFam001.1"
                     /label="G597_RS0106720"
                     /locus_tag="G597_RS0106720"
                     /protein_end="226"
                     /protein_start="140"
                     /score="37.3"
                     /tool="antismash"
                     /translation="FKLNAANYRYGNRVVQIYSINNNETEELNIKFTKVYQIIQKSCLE
                     KYVSFNQILNSILKVYGLEYKSLAENYIVSLIENHFLLSNL"
     gene            12975..14771
                     /locus_tag="G597_RS0106725"
     CDS             12975..14771
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002943315.1"
                     /locus_tag="G597_RS0106725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_049805326.1"
                     /transl_table=11
                     /translation="MDKLTVKKFFQTIFTIPKTLKMIFLLEKKNALYLIVLNAILSLLP
                     LANFFIYQELINSIFEKGNKIFYVLFIYALVQIFLSLLNQLILYIDSKFSMNLLYSLNL
                     KVQKKISLLSLIDFEQSETYNLIENITQDSTYKPFQLFNAIIGVISAFLSLLTSIVYIS
                     TWSSTLAIFLLLIPITSLIIFLRVGQLEFMIQWSRVNSEREVWYINYLLTHDFSFKEIK
                     LNGISQYFIQKYGKLKKSFIKQDLIIAKKKSIFNGGLDTVLNIINGVAIFTMVNSTRAG
                     KLLVGNFVSLIQALTRVNTYSQTMIQNVYIIYNTSLFMEQLFNFLNMRVENGKLNLQKQ
                     FDLGESVNCISVRNLSFSYPENTEKSVSNVSVDFKKGELVAIVGKNGSGKSTFVKLLSG
                     LYSPSEGEIFYDGKSNRALGLDFYQKNISVLFQDFVKYELSLRENIGLSNLKQLTDERI
                     KQCMETIGLDFLKQDVDYNLNQRLGTWFNDSRQLSGGQWQKVALARTFFKNASIYILDE
                     PSSALDPISEKEVFDDFIHRSANSISLFVSHSLSAAKKADRIIVMKDGRIINEGKHEDL
                     LKASDYYRELYYSERYEEISNG"
     gene            14764..16026
                     /locus_tag="G597_RS0106730"
     CDS             14764..16026
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000344171.1"
                     /locus_tag="G597_RS0106730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_024343844.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-59, bitscore:
                     197.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEREIIINLSEQLISDFDKKLVVNKDRFELMTLSSGLPGMIFLC
                     SELYELTKDEYYFSKIDSYIIFMVNQLKSQGVFSDSLFSGAAGIGICLLHLINYNSNYQ
                     NLINSLNNFIDYYTSKKIDEINVSSISPTDYDIIEGISGVLIYLLQLPDDCLKDLKLSI
                     VNFLSDLVLINPQYTGFYVESVNQMSDTESKFYPDGSLNFGVAHGLAGVGVALCYAKLR
                     GVFTGKSIMSIQRLVTFYEKYELPNHMWKEGLDRNELLLESVPNFVNEFIRDAWCYGSP
                     GISLFYLYSGIVLEDSELIEKACRILKTAVKRGNGLEQSILCHGYAGLVEICFTFRNVL
                     KNNKFDKEIEILYSQLLAGYDKRRRLGFDTSTEFEELRCEENIGFLDGIIGILLTMLHL
                     NSLNVFSNWQSAMLLFDDFTI"
     gene            16041..16778
                     /locus_tag="G597_RS0106735"
     CDS             16041..16778
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001226539.1"
                     /locus_tag="G597_RS0106735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NisI/SpaI family lantibiotic immunity
                     lipoprotein"
                     /protein_id="WP_024343845.1"
                     /transl_table=11
                     /translation="MKKTILLILVGFFCALGLAACGQFSSNDPKFEKNSFYQFSYEGKS
                     YTILNKTISENDIVSKKASFLKTIVVDKSNQRVVEKSNENTITLAYSGLYNSNNGLAIS
                     INSSYYRVILNSDLQSNDELLNINSIQNEDNSLGKEVGIDSSDCRVITYGDRKYQISDD
                     EVSEESLEDFKGIIADSRIFNPSTGQIIPKSELNKIDNTGKISQSGIETWDYGEVYSVE
                     RKSDQAAIAVEINNSYRLAYYIE"
     misc_feature    complement(16900..16911)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.14"
                     /tool="antismash"
     gene            16931..17689
                     /locus_tag="G597_RS0106740"
     CDS             16931..17689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232435.1"
                     /locus_tag="G597_RS0106740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YoaP domain-containing protein"
                     /protein_id="WP_027968569.1"
                     /transl_table=11
                     /translation="MKYIQVTKENLEEEHICCALSNNKDAQVLSKKAWLSERFDDGLVF
                     LKSIERGKCFIEYIPAENAWNPIEARDYMYIDCLWVSGSFKGHGYSNDLLETCIADSKS
                     KEKKGLCILAAAKKKPFLADPKYLKHKGFKVADEADNGIQLWYLPFDDDAVLPSFKDCA
                     KHPQVEEKGYVLYYTSQCPFNAKYVPILEETAREHGIAFKAIHLTSKEEARSAPTPITT
                     YAIFYNGDYVTNEQMNDKKFLKLVSRLEDK"
     gene            17746..17922
                     /locus_tag="G597_RS09180"
     CDS             17746..17922
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232433.1"
                     /locus_tag="G597_RS09180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_164554317.1"
                     /transl_table=11
                     /translation="MNRERGVAVAMCIGVLIGALIGALTHSIGLWTSLGIAFGLIAGLL
                     LSKDDDDSDNEFD"
     misc_feature    18009..18023
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.23"
                     /tool="antismash"
     gene            18041..18943
                     /locus_tag="G597_RS0106750"
     CDS             18041..18943
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010770036.1"
                     /locus_tag="G597_RS0106750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_027968570.1"
                     /transl_table=11
                     /translation="MKTVLVTGGTVFVSKYTADYFVKQGYDVYVLNRNSKKQVDGVTLI
                     QADRHDLGNRLKNLHFDVVLDVTAYNASDISCLIEGLGSFGTYIMISSSSVYPDDGAQP
                     FLETSQLGDNKFWGQYGLDKIAAENRLLELVPDAYILRPPYLYGPMNNVYREAFVFDCA
                     KDDLPFYLPRKGELKLQFFYIKDLCRMMEKIIENQPKEHLYNVGNSETISVRQWVKLCY
                     ACSNKIPEFIEVFNEVNQRNYFSFYDYEFFLDVERQKKLLPDLTPIAIGLKESYTWYEN
                     HIFDVKKKPFFDYIEKHLK"
     gene            18956..19606
                     /locus_tag="G597_RS08860"
     CDS             18956..19606
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013643271.1"
                     /locus_tag="G597_RS08860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transglutaminase family protein"
                     /protein_id="WP_049805820.1"
                     /transl_table=11
                     /translation="MNPGYLEANKYVDYYHPEIQKRARQLNAESNDEIDLVKNTFHFVR
                     DDIHHSWDVKDKRVTVSASDCLCEGVGICWAKANLLAALLRANGIPSGFSYQRLILGST
                     PDTGYCIHALNTVYLDSIGKWLRLDARGNKKNVQAEFSLDGEKLAFYPNDIGEIDYHDN
                     HSQPDRGLMAVLEKSTDAIDMYLHHLPDRLTEDIKLKRVITDREELAEQRKRL"
     gene            19608..20018
                     /locus_tag="G597_RS0106760"
     CDS             19608..20018
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009854514.1"
                     /locus_tag="G597_RS0106760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_027968571.1"
                     /transl_table=11
                     /translation="MAADIEYKSIQSFKCSDLEHLFLSVEWSSGHYPEKLVLAMQNFST
                     VYSAWDGDKLVGLICVMDDGVMNAYIHYLLVDPDYQDRTIGSHLLQLVKEKYKAFMRLA
                     VIGYNKEINFYENAGFVKSENCSALFLTSLWT"
     gene            20097..20861
                     /locus_tag="G597_RS0106765"
     CDS             20097..20861
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (14-110). E-value:
                     2.2e-08. Score: 25.9. Matches aSDomain:
                     nrpspksdomains_G597_RS0106765_Abhydrolase_1.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="G597_RS0106765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_027968572.1"
                     /transl_table=11
                     /translation="MLFHEFGDPSKPIIMLFPGTMCHWKANFEKVIPRLLSDFFVLVVS
                     YTGFDGEDREDFQSILAEVQKIEEMIQQNYQGKIFAAYGSSLGGTLVAQLVARKKVIMS
                     KAIIGSSDFDQENHLLALLKGKLLVMLMHPFLKNGYFVPKCVQSYFQKESSKDPYVRDI
                     FSFMTGLTFVSKQSLFNQFYSDLITPLSNMIENDETEVHIFYAEKMGEKYLKRYKKHFK
                     NPIIHRQNYRHEELLASYPEKWYQAVMAICNI"
     aSDomain        20139..20426
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_G597_RS0106765_Abhydrolase_1.1"
                     /evalue="2.20E-08"
                     /label="G597_RS0106765_Abhydrolase_1.1"
                     /locus_tag="G597_RS0106765"
                     /protein_end="110"
                     /protein_start="14"
                     /score="25.9"
                     /tool="antismash"
                     /translation="MLFPGTMCHWKANFEKVIPRLLSDFFVLVVSYTGFDGEDREDFQS
                     ILAEVQKIEEMIQQNYQGKIFAAYGSSLGGTLVAQLVARKKVIMSKAIIGS"
     gene            20891..21292
                     /locus_tag="G597_RS0106770"
     CDS             20891..21292
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232423.1"
                     /locus_tag="G597_RS0106770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ASCH domain-containing protein"
                     /protein_id="WP_049805821.1"
                     /transl_table=11
                     /translation="MNIENLEKWHFELTEDACNSLLDLVLKGQKRATSSSLAAFELGDE
                     TMPKEGELSVITDWDGNPRCVVRTKKLHILPYEEITYDLAKLEGEDETLDSWKRSHERF
                     FTREGEMLGYHFSPQMSVVFEEFEVVEVL"
     gene            21604..23259
                     /gene="sulP"
                     /locus_tag="G597_RS0106775"
     CDS             21604..23259
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015116 - sulfate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0008272 - sulfate transport [Evidence IEA]"
                     /codon_start=1
                     /gene="sulP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232421.1"
                     /locus_tag="G597_RS0106775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sulfate permease"
                     /protein_id="WP_024343851.1"
                     /transl_table=11
                     /translation="MDAFKYIKPKLFSTLKNYSGAQFAKDLVAGIIVAIIALPLSIALA
                     IASGVNPEQGLYTAVVAGFFISFLGGSRVQIGGPTAAFVVIIYGIIAQYGMAGLTIATF
                     LAGIMMIIMGLLRFGDLIKFIPKTITVGFTLGIAVGIFVGQLKDFFGLSMGAVPAEFVE
                     KMVAYAQHLNTIHWPTLMIGMIALLIQIFWPRVSQKIPGSLVAIIVTTAIVGFGHLSVK
                     TIGDLYTIKAGLPTFTMPELSFGLVRQMISPAFTIAILASIESLLSCVVSDGMIGSHHR
                     SNAELVGQGVGNMMSALFGGIPATGAIARTAANVKNGGRTPIAGMTHAVTLLLILLFLM
                     PYASLIPMSCLAAILIMVAYNMSGWRTFIHMLKKAPKSDIAVLVITLVLTVFFDLVVAI
                     EFGMVLAAFLFLKRMSDVAAVRQWVDKDSLDDAELSENTDLKHVPSNTVVYEIFGSLFF
                     GAANDFLNFNHEEGKNVLILRMRNVPAMDISGLEALEETLEICQKRGMTLILSHVNKQP
                     YHVMEKAGFVEKVGQENLCENIDASLKRAASLAK"
     gene            23428..25077
                     /locus_tag="G597_RS0106780"
     CDS             23428..25077
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004232414.1"
                     /locus_tag="G597_RS0106780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptide ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_024343852.1"
                     /transl_table=11
                     /translation="MDNKSTLKRVGLGAVSLASVALLAACGGGNKTAANKNEINWYTPT
                     EILTLDISKNTDQYSALAIGNSSSNLLRVDKKGEPKPDLAKSVEVSEDGLTYTATLRDG
                     LKWSDGSDLTADDFVYTWQRMVDPKTASEYAYLAVESHLENADKINTGEISDLSQLGVK
                     ADGNKITFKLTSPCPQFKYYLAFSNFMPQKKAFVEKEGDKYATTSKDQIYSGPYTIKGW
                     NGSDGSFTLVKNKYYWDAKNVKTEKVNLQAIKKADTAVQMYKNGELDTANISATSSIYK
                     ANKSNKEAVPVPEARMTYIVYNETGSVASLANEKIRQALNLATDRQGVVEAAIDTGSKP
                     ATALATPGLAKLTDGTDLSKYVEPGYKYDEKEAAKLFKEGLAELGTDSVKLTVTADSDD
                     AVTKAAVDYIKQSWEEALPGLKIEEKFVTFKQRLEDTKNQNFEVALVSWGGDYPEGSTF
                     YGLFSSTSAYNYGKVSSDEFDAAYNKALTEDALDTDAAAEDYKTAEKVLYEGAHYNPIF
                     FRSTKWLQNPSLKGLVRNSTGLTVDFTYAYKK"
     misc_feature    complement(25092..25104)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    25296..25309
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(25385..25401)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.69"
                     /tool="antismash"
     misc_feature    25834..25849
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.05"
                     /tool="antismash"
ORIGIN
        1 cggaggaaat atggtaaata taaaatcaga ggctgaaaag cttgctatag ctaataaatt
       61 tttagtaaca agcgagcgat tatttgccaa gtatggctat ttaggagtga gtctgtcaga
      121 agtagcaaaa gaatccggcg tatcaaaagg aacattgttt aactatttta ccaataaaga
      181 aacgctcttt atgtgcttat tgttacgtgg ttatcagcag tattttgaaa tcccttttga
      241 gaaactttct tctcttccta acttgtcaga tgctgagttg ttagattttt ttgagaaaga
      301 aacacgttat ttgattcaaa ataagattac tttattaaga ttaaatgcct tacgtgctcc
      361 aattttagaa agaaaagctg ataaaaatca gacaattgag ggaagaaagg tcttaaataa
      421 caaaattaaa ttagttggtg aattattagc acaaaaagta tcaggaatgt cagcagacag
      481 cattgcgcat cttttttaag cccaagcagc aattttaagc gggttattga acatgtctga
      541 gctggagtca tttaaccaag agagtattga gttaacattt gatacttttc aattaaatat
      601 ggtagcagat ggtattgaaa tggtaagggt ctatgttact catgaactac aaaaaagagg
      661 taaaattaat gcaggataga atcagaaatt ttgcgattat tgctcatatt gatcacggaa
      721 aatcaacact tgcagatcgt attatggaaa tgactgatat ggtaagtctt agagactcta
      781 ctgatcaaca agtagataat ttatcagtcg aaaaagcaca tggtgtcact gtcaagtcat
      841 gcactgttcg aaattgttat catgcaaaag atggacaaga ttatatttat caattgattg
      901 atactccagg gcacgttgat ttttcttatg aagttgaaaa aagtttaaca gcatgtgaag
      961 gtgtattatt gttggtggat gcgacacaag gtattcaggc acaaacattg gcaaattatc
     1021 aaattgctaa ggctactggt ttgaccattt tgccaattat taataaagtt gatggtccaa
     1081 atgcagatgt agaaaaagtc gctcgagaaa ttcagaattt ggataacact ttgtcaaaac
     1141 cactacttat atcagctaaa actggtcaag gggtttcgga agttttagaa gcgattcatt
     1201 tagtcattcc tgctccaaaa gggaaaatag acgagctatt gaaggcttta gtttttgatt
     1261 ctttttatga tagttataaa gagttgtcgc tctaattcga attattgaag gcaaattgaa
     1321 aagtcatcaa aaagtccaat ttgttcctgg ccaagtgtat actaagccaa ctgagattgg
     1381 tgttttaact ccagatatgc aagcgacaca ggagctgaaa gcaggagaag tcgggtatgt
     1441 gattcctagt cttaaagatc ctaaatcagt gattgtgggt gacactttaa caactattgc
     1501 caacccaacg aagagacccc ttgtgggcta tcaagaacct cagtcaatgg tgttttaaag
     1561 ataaggaaga tgaaaagtta aaagctggta ttgaaaaatt gggcttgaat gatccgtctt
     1621 ttcaatttca gcctacacaa tctgaagcta tgggagtggg ttttcattgt ggatttttgg
     1681 ggatgtttca tttacaaatt atcagggaac gtttaaaaga agagtttcaa ttagacgttt
     1741 taacaacagc tcctagtgtg acctatcatg tttttactaa aaatggagaa aagttaaacg
     1801 ttagccatcc cgtacacttt ccagactttt ctcaaattaa aagtgtacaa gaaccatata
     1861 tgacagccaa gataattact tcaagtgata gtttaggagc tatgatgcag ttagctgaac
     1921 agcataaagg taatttattg atatgggcaa ccaaggggaa tatgtagtct tgaattatga
     1981 gatgccacta tctaaaattt catatgactt ttttgataag ttaaactctc agtcgtatgt
     2041 gtatgctagt ttagaaacac attttttgaa ttatcaagat gctgatgttg tcaaagttga
     2101 agtagcaatt aattatgtta acgtagatgc tcttagtttt attattcatt gtgatgaagc
     2161 tcatgagatg acgcaaaaac tagtacataa gctgaaatat agtgtttata ctcaatgctc
     2221 gctcaggcag ttgttgaaag aaaagttttg gcgcgtgttg atattccacc tttgaggaga
     2281 aatgcagcag ttaacggaga gaaacgcagt atttctaaga agcaagcttt atttgtcgtc
     2341 aaaacattaa taaacgacaa gctgcaggaa attccattac cattacacaa gaagtacttg
     2401 atgttctttc tttagaaatt taaatcatta ataacttttg atagattaag gctcaggtga
     2461 taggaaactg cttttataga ctgtaacata taagtgttac agttttttat tatggcttca
     2521 agccagtttt tctcgaagag aaaaacaaga aaaccaccag ttaagctggt ggctgacatg
     2581 acttttaatt aatattatta gtttcatgcg tagaatttat ttcctaacca atgagaaaaa
     2641 tggtaggagt tatcggtatt aagatagaac caagaataaa ggagagtgta cacatctata
     2701 tcatcaaata ggtcataagc ccaattatta ggatagataa aatgctctaa gtcttcatca
     2761 gataactgct caacgatgtt ttctataaga atggttgatt cttccataat taaatataag
     2821 catatttcat ttagaacaga attagcgact agctttataa cttcttttgc tctcattcta
     2881 aaacaatcga tgttgttaga atgagaatag ataaattgat aatcatattc tattaggaat
     2941 tgttttgggg agtatgctgg agagaaaaga ggtatctaat tctccaatat gtgttccttt
     3001 tggtctttct gatcatgctt catgtttttt atatttagaa agaatagtct ctaatgagga
     3061 gtttttacta tcaagctcag gaggaatttc ttgccatttc aaagttctaa taatactatc
     3121 taatttgtct tttcgaatag gattgccaga ctcataacga ctccatgttt ttgttccaat
     3181 tgcagttttt tttgcagctt cttcaattgt gagacctaat tcgatatgtc gttgttttat
     3241 agattgagct atattttcgt tatttttaaa agatgtttta ggcataatgg ttctccttgt
     3301 gctttttatg accggtcact tttaaaaatc ttatcactaa aataattttc ggtcaattaa
     3361 ttgttaggta aagtaaaaat tagacatttt ttcaattttt caaactagat atgctcaact
     3421 tatctagttt gaaaattaat ttaaggttag tatatttatt ggtagaatga tatacttatt
     3481 aaagtaattg ttgatggaat atgaattgag aaatttttgc atttaaagat ttcaattttt
     3541 cagaaagaaa cttattctga accttttctg aaatgttgtt gctaaaattt tttcaaaatt
     3601 ttagaggttt aattatgaag aagagttatt cgatatttct ttttgtttgt ttcttgccac
     3661 tttgtctttt tgattgtttt tttaacacaa tttatgcgga agattgtaat aatactaagt
     3721 atgaggtatt ggtgaaagat aatgaatcaa ttaaaatagt tacagaaaat ttccaatctc
     3781 aagggataaa tatcatcgat gaagttcctg aaattaatct tatattaatt tcaacagata
     3841 aaaatcctga gacattaaaa ttggagaata atagctatat tgatggtatg gttaaagaaa
     3901 atgagacaac agtaaaacct gaaattagtt attggtttgg ggaaaggcaa tatacaaatg
     3961 atgaatcaga tttttggtta aatcaatggg atatgcaaaa aagtactcaa actggtgaga
     4021 aatttactca taaatcttca ggaaattcag tagttggtgt tattgattca ggaattgatt
     4081 atagtaattc agaaatttca tctagtatca tttctgctca aaattttact acggattctg
     4141 aaggtaatgt tgatagtgga aatatagcag ataagatagg acatggaaca tcggttgtag
     4201 gtcaaatttc atcaaatggt aaatatttag ggatagctcc taatatgaga gtgagaatgt
     4261 atcgagtatt tgacgaggaa aatgcacagg atttatggat tttaagagct atcatacaag
     4321 cagcaaatga tgatgttgat gttcttaatc ttagccttgg tgaatatttg ataaacgctt
     4381 ctaattgcaa agattatgat agtgtgttaa ttgaagctta ccaaagagct atcaattatg
     4441 cacataatca aggaacagca attgtggctt cagtgggaga tgagggactt gatttaacaa
     4501 atcaagaaca gttgaagagt tatattggtt ctttaaatgg tgataattat aaggaaaatg
     4561 atggacaagt taaagatatt cctgcagaat tagataatgt tgttactgta gggtctatag
     4621 gggatagtga tagagtgtct agtttctcaa ataaaggtaa tggtattatt gatatctatg
     4681 ccactggtgg aggaagtgaa agacttttat taacaggata cgaagagtgg ttggataaaa
     4741 aattatatga aaaagatttt gttcttgttc caacgttgga aggtaagtac acatatgaat
     4801 atggtacctc tctttcagct ccaaaagtgt cagctacatt gggattgatt atagaaaagt
     4861 atcatttgaa agataaacca gacgaggcaa ttaaaatatt atataatact tgtagtcggt
     4921 tatgtaatga tgcaactggt gcccaattta gggtactaga tattacaaat cttgttcgat
     4981 agcattgggt gaatatatta ggagatatga atgtataaaa ttttagttgt agatgatgat
     5041 tttgagattt tgaaattgat gcgtacgatt ttggagatga aaaattacga tgtgacaact
     5101 tatcagggaa taacattacc gctaaatagt aaggattttc aaggctttga cttgattttg
     5161 cttgatgtta tgatgcctga tattgatggc ttgcaagttt gcagacagat tcgtgacaag
     5221 gtgagtgcgc cgattatttt tgtgagtgca aaagatgaag aagatgatat tgtcactggt
     5281 ttaaatcttg gtggggacga ttatattaca aaaccattta gtgtgaagca gctggtggct
     5341 aaggttgctg cgcatttaaa acgtgaagaa cgctttagac aagctgaatc tgatgagaaa
     5401 attatccgtg aactgctgcc gattacattt tacttgcagg aaaaaacagt ttgtgttaat
     5461 ggcaatattg tcccgttaac cagcagagaa tatgatttgc tggatttgct atcagccaat
     5521 cgcaataaag tttttacgcg ggaagatatt tatagccaca tttacgatga tgaggcagat
     5581 gcgctatttc gctcgatatc ggagtatgtt tatcagataa gggtgaaatt ttctgcatat
     5641 gatattaatc cgattaagac tgtaagggga atgggatata aatggtatga ctaaacagta
     5701 ttcaatcaaa agaagagttt tacgttgcgt ttctgagata gtgattggga cggtgcttaa
     5761 tgtttttgtg ctctttttac tcagctatgt tttagcgatg actggtcagc taaatagtta
     5821 cggttctgat tttaaagttg atattaaaga tagtgcttct gctgagaaga ttgctaagcg
     5881 gttaaaccaa acgacttttg attatatatt atttgaaaag tcttctggaa aaatcagctc
     5941 aggtaagtat cagagagaag actatggctg ctatagagct gcctttaatc atgctaggtc
     6001 tgaggatttt ggaacgattc gctacgcaaa attcagtaat tcaaattatg tgcttatcgt
     6061 tagatgtccg actttgcctg aatttgttaa ccctaggtta aggtatttat cgtttaacaa
     6121 tttttcgtat ttgtttttct tgatactaga actcatttta gtcatttggt cagtttcaag
     6181 gctcttaaag gaattcacta aaaattttcg attaattcaa gagatttcta tgaatatggg
     6241 acagcctgaa gtagcaatca aacgttctca gactgaaatg acagagttca atgacatttt
     6301 atcaatgctt taccagaaag atgcggagct agttgctttg cttcaggcag agcgaaaagc
     6361 aaagaaagat ttgtcctttc aagtggcagc tttggctcac gatatcaaga cccctttgac
     6421 agttttaaag ggaaatttgg agttgcttga aatgactggt ttaacaaaag aacagttaga
     6481 atttctgaca tcagctaata acagtatcca aacttttgag aaatatttta atgacatgat
     6541 tcattattct cgcttgctgg tggaagaaaa aaattatcag gaagagattt gtttatcaga
     6601 atttttagaa gaactgacta ccgaagcaaa ggcaatcatg gatgcgcaag gagctgaatt
     6661 tggtgtaact aagcgcgtga actcagaatt tttcaaaggg aatcaactta atttaagtcg
     6721 tgcgctgatt aacatcttgt caaatgctgc taggtatagt tcgggtcata aaaaagtaac
     6781 actctcagtg attgagaagg aagattttct gacttttacc gtttggaata atggccctgc
     6841 ttttacaaaa gaggctttag agagtgcaga taaccttttt tacactgaaa ataaaggtag
     6901 aagtaacaag cactatggca ttggtctgtc atttgcacaa gcagtcgcta aaaaacatca
     6961 cggaaaactt gtcttgcaaa atcctccaac gggtggagcg acagttagct tatctatcaa
     7021 gaaatagcaa ctctggtata cacaatgatt tgattaatta gaagtcacaa tatgtggttg
     7081 tcacttcaaa aaaacgtcac aatataatta tatgaagagg ttgagtttaa aagtgttcaa
     7141 cctctttgtt tattttgcca tgatagacaa agcaaagtgc aatgattgag ttaaaaagga
     7201 gcggaaattg aaccattttt atttgaaaat aaaacttagg gaataggtgc caaaaagatg
     7261 gctttaaata ggccatttta ggtcagtaat gaaaaattaa gaattgtttc aaggttgaat
     7321 atctttaaaa ttaccaaatt ttgttctact ctatttcatt tttctgaaca aattctgaac
     7381 tagtgatttt aaactgaata tgttcgaaca aagaaaaaga aaagaggagg aattcacagt
     7441 gagtaatgaa gattttaact tggatttagt ttctgtctca aaaaatagta attctggtgc
     7501 ttcacctcgt attactagta aatcattgtg tacacctggt tgtaaaacag gtgcgttgat
     7561 gacttgtcca attaaaactg caacatgtgg ttgtcacttt gggaattaag tatcacagtt
     7621 tgattaggtg aaatagcatc tttttagatg ctattttctt tttttctgaa caaatgctga
     7681 aaaaacctcg ctatagttaa tgtgtaaaaa aggaggttga gctatggttg ttcaagttaa
     7741 gaatttgaaa aaatccttta aagataaaga gatattaaaa ggtatttcat ttgaaattga
     7801 aaaaggaagt gtctgtggct tgcttggtgt taatggagct ggtaaatcaa ccattatgaa
     7861 aatcattttt ggcttagaag aagctgacag tggtgctgtt gtttttaatg gtgaacagat
     7921 tagtgaaaaa tctagtgcag attttaacat cggtgctctt attgaatcac cagcgattta
     7981 tatgaatttg tcagcttttg ataatctaaa aacacgcgca ctcttatatg atatttctga
     8041 cgttcgaatc aaagaagtgc tgaagttgat tggattatct catacaggta agaaaaaagc
     8101 tgggcacttc tcattaggga tgaaacagcg cttgggtctt ggtatggcga tgataacaaa
     8161 tcctgatttg ttgattttgg atgagccaac aaatggttta gacccagatg ggattaagga
     8221 attattggat ttgatttctc atttgaaaaa tactggcatg accattcttt tatcaagtca
     8281 tcagctccat gaagtgagta aagttgctga ccacattgtc attttacatg atggcgaaat
     8341 tttttatgat gaagctaata ctcatgatgc tgatttagaa aaattattct ttaaaatcgt
     8401 tcatggaggt gcttaggatg aaaaagatat tgaaatcaga atggttaaag caaaagtcaa
     8461 gttcagataa aaaattattg ttctttgtgc cttttttgac gatttttatc gcagtattgc
     8521 tttctggtta cagcctttta gaaagctttt cggtttattg gtgggaagct atctttttgt
     8581 acactttaat cggattgttg tttctttacg actataaagc agaagaaaaa gcggggcatt
     8641 ttcaaaatat tcatctagga aaagacacct ttaaaattta tcttgccaag atgttgttaa
     8701 aagtgaaaga tatttttgtg gcaacggtaa tcttcactgt gattttctat cttgtttcgc
     8761 ttttattttc aggagtgatg tcggtgaata tcggcaaaga ttttctttgt ctgcttctga
     8821 ttatgttagc ttccatctgg aaccttccat ttctttattt cttgtcaaaa tggctgagtc
     8881 cttacctttt attggcagga aattcattga tttgcctact ggtggcaccc tttttagcac
     8941 aaataccaat ttggtatgtt tttccttata cttaccatta taaaattgct tatggcatga
     9001 tgcgattaaa accgtcaggt gatttagatg ttgcaagagt ggttgatgtt cagctgattg
     9061 ttacggcact ggtattatct tttttgatgt gtttgctatt tatattttta ctaaaatgga
     9121 gggaaaatag cgatgaatta tctaaaaagt gaattgttaa aatggaaaaa ttcctatgct
     9181 tgttacttaa tattagtcct ttcagtttta caattagtga caattttgcc gtatgttttg
     9241 cttgttaata acccgactat actggaaaat cttattttta tatacatgct tggttattgc
     9301 attgtgatga gtgtcatgtc tattttgcta cacgagcaag aaatggatgc caatcatttt
     9361 caaaacatca gaagcgaaaa atgcagattg accatttgga caatgaagct tgtggctgct
     9421 gatttggtag tgatggttcc cacatttcta ctttggctag cagttggtgt tgaggtcaat
     9481 aacatttctc attttgccta tgctggcttg attatttgct tgctgctagt tatgcttaat
     9541 cattttcata tgtttttgag tctatttatg ggaaaaggcg gtaatcttct gatttcgttt
     9601 gtcgaatgtt tgtttatcgt ttttgcgaca aacaaagctt ttctaaacgt gctttggatg
     9661 ccaattgcac ttccggttaa cttaattttt acttatacag tgacaagttt gctagcctta
     9721 ttgggctaca tcatactgtt ttattttggg aacttggtaa tgcttagtag gatgaaattt
     9781 tgagcaagct tttctgaaca aattctgaat ataacatcat ataatctaga tgtttgtaaa
     9841 ggtatggata ttaattagaa taagtttatg ggaaatttat atagcatttt acaaaacaag
     9901 tgaagttgga aaaggtagta tataaaatag ctacctttat ttttataagt actcaaatta
     9961 atttgagtac ttataaaaat aaaaaatgga gataaggagt atgaaatata aatataacgc
    10021 cgatagcttt ttagtacgaa atacaataac agaggaaaag tccctccaat tttatgatta
    10081 tgttaccttt ttaaattatg tgaaggaaga taagaagttt caagagcagc tttttgttgc
    10141 aagtagaagt ttgtatgatt cacttcaaaa gtactataac aatacgccta tgaaaaagaa
    10201 aaagattagg caaatgtctg agtcgattta taaatattat aagcgtagta ttgatcgatc
    10261 aacgccattt ggtttgttta gtaaaacatc agttggagag ttttctgatg aaaatcagtt
    10321 gatattgaat tcaaaagcaa agaagagtat tttatttgat ttagagtggt tgacttcatt
    10381 agttttcaag attgaaaaga agtattatcg aaaactttac ttcaaactta atgcagctaa
    10441 ctataggtat ggtaacagag tagttcaaat atattctatt aacaataatg aaactgaaga
    10501 attgaatatt aaatttacga aagtttatca aattattcag aaaagttgtt tagaaaaata
    10561 tgtttcattt aatcaaattt tgaattcaat tttaaaagta tatggtcttg aatataaaag
    10621 ccttgctgag aattatattg ttagcctaat tgagaaccat tttcttctct caaacttaaa
    10681 ttatgactta gtttcagatt ttgatagaaa aaaatttata tctgaggtaa agaaagttga
    10741 tgaagaagat gctttttata gcacattgtg taaaatagtt agactaatag atgagtattc
    10801 aatattacag attggagaag gaattggtaa actagaatat atttacggtt taatgtcgtc
    10861 tcttgttaag actaataatt ttttacaaat agacttacat gatacaggac acgccaaatt
    10921 aaactttagc ttaaaaaaac aaattgttga gttttcagaa tttttatcaa atctttctac
    10981 cagtgttcaa aaaagttatt tagataattt taaggatctt tttttagaga aatatggttt
    11041 atatagggaa gtacagctag ttgagctttt tgatagtaat atgggcttag gggctcctta
    11101 tggatataca catcctcaaa attattgtta tgaatcaaca ccaaaaacta ttttttattc
    11161 tgaaacagaa gaaaaaatgt atttaaacga actagaactt tctttagaat ctggaaaatc
    11221 tatacagtta aacaaattta agcgatatta taagaattta caaggaaatg ttaataaagt
    11281 aaaccaaggt tttgaactat ttttcaatat taattatgaa aataatgatt gcatactaag
    11341 tttaggaagt gctggatgtt caaaaaattt aggagctagt tcaggtagat tttctgtaat
    11401 atcagatgaa ttaaaagaat atcatcgaga taacgcaaaa gtcatagaag atttgaattc
    11461 tgatttaggt tataatacgt gtgagatagt ttttcttcca gaaaatcttc gtcatgctaa
    11521 tgtaatgcgt acagataata ttagacaaaa aacattatca ttatttacat ataatcgagg
    11581 agagcaaata aaattatcag atatttatat cggaattgat gctcaaaata atttttatgc
    11641 taaagaatgt aaaagtggaa agcttgtaaa attttatagc actaatatgt acaatcagtt
    11701 gctttttagt aatgagttaa gatttttgtg tgagatttct ctagataatc attttggaat
    11761 gtttccatgg gaaattattt ttcaaaagtt ttcttatgtt ccaagaattg tatatggaaa
    11821 tcttattgtt gcacctgccc gttggaggtt aagtggtgat gatatcgatg atgatattga
    11881 acatattatt actaagcata atttgccgct ggagttttat gttgataatc aggataatcg
    11941 aattttaatt aatcaatcaa atcatttaga taaagaatta tttgcaagta ttataagaaa
    12001 ggcgaaatta aaaaatgagg aagttaacct ttcagagtgt atttctgcaa tttccctttt
    12061 aaataagaaa aataaaagat atgctgctga tatagttgtt ccagttaagt gttcagatag
    12121 aagtcagttt aaagttgaaa atattgagat gcctgaagcg atatcaataa gtgaacgtca
    12181 aaaacttcca tttgaagatt ggctatactt aaaattatat atgtcttcag ataggcaaga
    12241 agaatttctt tcggatgtta tgccttctat ttttaattta gtaaaagaaa aaggagggaa
    12301 agcattttat attagatata cagatccaaa gtttcatata aggttaagga ttaagggaca
    12361 agacttatat agtatatata caaaaattca aaagatcctt caaaaaagta ttgataataa
    12421 tttaatatca actgtagaca tttctactta cgatcgagaa atagaacgct atggtggatg
    12481 tcaaaagatt gatttagttg aggatatttt ttgtattgat actgaggtag taattaatgc
    12541 tttatcatta ttaagaacgc aaaaaataca tttgacagtg gaagagttgg cgatagtact
    12601 taattatttt tatttaaagg tagtatttaa aaatcaaaat gataaaatta ttcatttttt
    12661 agaaaatgtt tgtcctaagc acactgtaaa taagaacagt gaaaaacata aaaatatgtc
    12721 actggtacaa gattatgtaa ataattgtca aatttttgaa attctgccta atttacatga
    12781 gttagctcaa aaagttaaaa aattgtctta caattgtaag gactttttag aagactatca
    12841 atatgctatt tatgatagta ttattcatgt tcataataat cgattaattg gaattgatag
    12901 agaaaaagaa gaagttattt acgatattat tcgtggtctt gtaataagtg aagagttcag
    12961 aaatggaatg tctaatggat aaacttacgg ttaaaaaatt ttttcaaact atttttacaa
    13021 ttcctaaaac attgaagatg atattccttt tggagaaaaa aaatgcttta tatttgatag
    13081 ttttaaatgc aatactttct ttacttccgt tagctaattt ctttatttat caagaattaa
    13141 taaattcaat atttgaaaaa ggtaataaaa ttttttatgt attgtttatt tatgcattag
    13201 tacaaatttt cttatctctc ttaaaccaac tgattttgta tattgattca aaatttagta
    13261 tgaatttatt atatagtcta aatttgaagg tgcagaagaa aatatcattg ctaagtttaa
    13321 tagattttga acaatcagaa acttataatt taattgaaaa tattacacaa gatagtactt
    13381 ataaaccgtt tcaattattt aatgcgataa ttggtgttat ttcagcattt ttatcattgt
    13441 taacaagtat tgtatatata agtacttgga gcagtacttt agcaatcttc ttattattaa
    13501 ttcctattac ttctcttata atttttttac gtgtaggtca actagaattc atgattcagt
    13561 ggagtcgagt taactcagaa agagaagtct ggtatattaa ttatcttctt actcatgatt
    13621 tttcatttaa ggagataaaa ttaaatggta ttagtcaata tttcatacag aaatatggaa
    13681 aattaaaaaa aagttttata aaacaagact tgataattgc taagaaaaaa tcaatattta
    13741 atggtggttt agatacagtt ttgaatataa taaatggtgt ggcaattttt acaatggtta
    13801 attcaacacg tgccggtaag ttattagttg gtaatttcgt cagtctgatt caagctctaa
    13861 ctagagtaaa cacctattcg cagactatga ttcaaaatgt ttatattatt tataacacaa
    13921 gtttatttat ggaacagcta ttcaattttt taaatatgag agttgaaaat ggcaaattga
    13981 atttacagaa gcaatttgat ttaggagaat cagtaaactg tattagtgtt agaaacttat
    14041 cattttctta tcctgaaaat acagagaaat ctgtatcaaa cgtgagtgtc gattttaaaa
    14101 agggtgaatt agtagcaatt gtaggaaaga atggatctgg aaaaagtaca tttgttaagt
    14161 tgttatcagg tctatatagt ccttcagaag gagagatttt ttatgatggt aaatctaaca
    14221 gagcgttagg attggatttt tatcaaaaaa atatatcagt attatttcaa gattttgtaa
    14281 aatacgaatt atcattaagg gaaaatattg gattatcaaa tttgaagcaa ttaactgatg
    14341 agagaataaa gcagtgtatg gaaactattg gtttagattt tttgaaacag gatgtggatt
    14401 ataatttaaa tcaacgtttg gggacttggt ttaatgatag ccgacaactt tcagggggac
    14461 aatggcaaaa agttgctttg gcaagaacat tttttaagaa tgcttcaata tatatacttg
    14521 atgaaccaag ttctgcgctt gacccaattt ccgaaaaaga ggtgtttgat gactttattc
    14581 atcgttcagc taatagtatt tcattatttg tatcacacag tttaagcgct gctaagaaag
    14641 cagatcgtat tatagtgatg aaggatggtc gtattataaa tgagggaaaa catgaagatt
    14701 tattgaaagc ttcggattat tacagagaac tatattattc agaacgttac gaggagatct
    14761 caaatgggtg aaagagaaat aataattaac ttgtctgaac aattaattag tgattttgat
    14821 aagaaattgg tagttaataa agatagattt gagttgatga cattgtcatc tggtttacct
    14881 ggtatgattt tcctatgttc agaattatat gaattaacaa aagatgagta ctatttttca
    14941 aaaattgatt catatattat atttatggtt aatcagttga aaagtcaagg tgttttttca
    15001 gactctctgt tttctggtgc agctggaata ggaatatgtc tattacacct gataaattac
    15061 aattctaact atcaaaattt aattaatagt ttaaataatt ttattgatta ctatacttca
    15121 aaaaaaattg atgaaataaa tgtctctagt atctcaccta ctgattatga tattattgag
    15181 ggaatttctg gagttttgat ttatcttttg caacttcctg atgattgttt aaaagatttg
    15241 aaacttagta ttgttaattt tttatcagat ttagtattaa ttaatcctca atatacagga
    15301 ttttatgtag aatctgtaaa tcaaatgtca gacactgaat caaaatttta tccagatggt
    15361 agtttgaatt ttggtgtagc tcatggctta gcaggagttg gagtggcatt gtgctatgca
    15421 aaattaagag gagtatttac aggtaaatca attatgtcta tacaaagatt agtcactttt
    15481 tatgaaaaat atgaattacc gaatcatatg tggaaagagg gcttagatag aaatgagttg
    15541 cttttagaaa gtgtcccgaa ctttgtgaat gaatttataa gagatgcttg gtgttatggg
    15601 agcccaggta ttagtttatt ttatttgtat tctggaattg tattagaaga tagtgagtta
    15661 atagaaaaag cttgtagaat attgaaaact gcggttaaaa gaggaaatgg attagagcaa
    15721 tccatattgt gtcatggata tgctggatta gtagaaatct gttttacatt taggaatgta
    15781 ttaaaaaaca ataagtttga taaagaaatt gaaattctat atagtcagtt gctagctggt
    15841 tacgacaaaa gacgtcgttt agggtttgat acatcaacgg agtttgaaga actacggtgt
    15901 gaagaaaata ttggtttctt agatggtatt attggaattt tactaactat gcttcattta
    15961 aatagtctaa atgtattttc taactggcag tcagccatgc ttctttttga tgattttaca
    16021 atttagagta gggagaaaaa atgaaaaaaa caatactatt aattcttgtt ggattctttt
    16081 gtgctttggg attagctgcg tgtggtcagt tttcaagtaa tgatccaaaa tttgaaaaaa
    16141 attcttttta tcaattttct tatgaaggaa aaagttatac gatattgaat aaaacaattt
    16201 cagaaaatga catagtttct aaaaaggctt cttttttaaa aacgattgta gttgataaat
    16261 ctaatcaaag agttgttgaa aagagcaatg agaatacaat aacactagca tatagtggtt
    16321 tatataattc taataatgga ttagccatat caattaattc gtcatattat agagtaattt
    16381 taaattctga tttacaatct aacgatgaac tattaaatat taatagtatt caaaacgaag
    16441 ataattctct tggaaaagaa gtaggtatag attcttctga ttgcagagta attacttatg
    16501 gtgatagaaa atatcaaata tctgatgatg aagtttctga agaaagttta gaagatttca
    16561 aggggataat tgcagattct agaattttta atccttctac aggtcagata ataccaaagt
    16621 cggaattaaa taaaatagac aatacaggga aaatatctca atcaggaata gaaacttggg
    16681 attatggtga agtttactct gtagaacgaa aatcagacca ggcagcaatt gctgttgaaa
    16741 ttaataatag ctatcgcttg gcttattata ttgaataatt aaatcaacca gacaatctat
    16801 ttttgtctgg gttttatttg tcaaaattcc gtaaaaatca agtgagttcg gttttctttt
    16861 gaaagattat agtgtttttg ctacaatgaa aataacaatg atagcgtttt ctttaagagg
    16921 aggtatcggc atgaaataca tccaagtaac aaaagaaaat ttagaagaag agcatatttg
    16981 ctgtgccctt tcaaataaca aggatgcgca agttttgtct aaaaaagctt ggctttctga
    17041 gcgttttgat gatggcctgg tgtttttaaa aagtatcgag cgtggcaagt gttttatcga
    17101 gtatattcct gctgaaaatg cctggaatcc gattgaagct agagattaca tgtatattga
    17161 ttgcctctgg gtttcgggga gctttaaagg tcacggatac tcgaatgatt tgcttgagac
    17221 ttgcatcgct gacagtaagt ctaaggaaaa gaagggcttg tgcattttag cagctgctaa
    17281 gaagaaacca tttcttgctg acccgaagta tctaaaacac aaaggcttta aggtggctga
    17341 tgaggctgat aatggtattc aactttggta cttgccattt gatgatgatg ctgttttgcc
    17401 aagttttaaa gactgcgcca aacaccctca ggtagaagaa aaaggttacg ttttatatta
    17461 cacgagccag tgcccgttta atgcaaaata cgttccaata ttagaagaaa ctgctagaga
    17521 gcatggaatt gcttttaagg ctatccatct tactagcaag gaagaagcaa ggtcggcacc
    17581 gacaccaatt acaacttatg ctatttttta taatggcgat tacgtgacaa atgagcaaat
    17641 gaatgataag aaatttttaa aattagtttc aagattggag gataaataag tcaaattttt
    17701 aaatgattag gggataatag cttttaaatt taggaggaga gtattatgaa tagagaacgt
    17761 ggagttgcag ttgcaatgtg tattggtgtc cttatcggag cgttgattgg tgccttaaca
    17821 cacagtattg gcttgtggac gtcacttggg atagctttcg gacttattgc tggtcttttg
    17881 ttaagtaaag acgatgatga tagcgataat gaatttgact aatttttatg gggaaaataa
    17941 aaggattagc actgaaagca gtagttcttt gtaactgctg tttttttgtg ttacaatgca
    18001 ggtatcataa tattctgata attagaagga ggtttctagg atgaagacag tgctcgtgac
    18061 gggtggaacg gtttttgtga gcaagtatac ggcagattac tttgtgaagc aaggctatga
    18121 tgtttatgta cttaatcgaa atagcaaaaa acaagtcgat ggtgtgactt tgattcaagc
    18181 tgatagacac gatttaggca atcgactgaa aaatcttcat tttgatgtcg ttctagatgt
    18241 gacagcttat aatgcttctg atatttcttg tctcatcgaa ggacttgggt catttggaac
    18301 atacattatg attagttcaa gttctgttta tccagatgat ggagcacagc catttttaga
    18361 aacctctcaa ctcggggata ataagttctg gggacaatat ggtttagaca agattgcggc
    18421 tgaaaaccga ctacttgagc ttgttccaga tgcttatatt ttacgtccac cttatttgta
    18481 tggaccgatg aataacgtct accgcgaagc ttttgttttt gattgtgcca aagatgattt
    18541 gcctttttat ctgccacgca agggtgaatt aaaattgcaa ttcttttata tcaaggattt
    18601 gtgtcgcatg atggaaaaaa tcatcgaaaa tcagccaaaa gaacatcttt ataatgttgg
    18661 aaatagcgaa accataagtg ttcgtcagtg ggtgaaactc tgttacgctt gcagcaataa
    18721 aattccagaa tttattgagg tttttaatga ggtcaaccag cgcaattact ttagctttta
    18781 cgattatgag ttctttttag atgttgaaag gcaaaaaaag ctcttgcctg atttaacacc
    18841 aatagcaatc ggcttaaaag aatcttacac atggtatgaa aatcacatct tcgatgtcaa
    18901 aaagaaacca ttttttgatt atattgaaaa acatttaaag taagggagtg attccatgaa
    18961 tccagggtat ttagaagcaa ataaatacgt tgattattat catccagaaa ttcaaaaacg
    19021 tgctcgccag ttaaatgcag aaagtaatga tgagattgat ttggtaaaaa acacttttca
    19081 ttttgtgaga gacgacatcc accattcatg ggatgttaaa gataagcgcg ttacagtttc
    19141 agcaagtgat tgtctttgtg aaggtgttgg catttgttgg gcaaaagcta atcttttagc
    19201 agcactactt cgtgccaatg gtattccgtc aggtttttct taccagcgct tgatacttgg
    19261 atctactccg gatacgggct attgcatcca tgctcttaat actgtctatc ttgattctat
    19321 aggaaaatgg cttcgcctag atgctagagg aaataagaaa aatgttcaag cagagttttc
    19381 gttagatggt gagaaacttg ctttttatcc taatgatatt ggagagattg actatcatga
    19441 taatcattca caaccagatc gaggtttaat ggcagttctt gaaaaaagta ctgatgctat
    19501 tgacatgtat ttacatcatt tgccagacag attaactgaa gacataaaac taaagcgcgt
    19561 gataactgac cgagaagaat tagctgaaca aagaaagagg ttgtagtatg gcagctgaca
    19621 ttgaatacaa atctatccag agtttcaagt gcagtgattt ggagcatttg ttcctttcag
    19681 tggagtggtc ttcggggcat tatcctgaaa aattagttct tgctatgcag aattttagta
    19741 ctgtttattc agcgtgggat ggtgacaaat tagtcggctt gatttgtgtc atggatgatg
    19801 gcgtgatgaa tgcttatatt cattatctgc ttgtagaccc tgattatcag gatcgtacta
    19861 ttggcagtca tttgcttcaa ctggtcaagg aaaaatataa ggcatttatg agacttgccg
    19921 tgattggcta taataaagaa atcaactttt atgaaaatgc aggttttgtc aaaagcgaaa
    19981 actgttcagc gctgtttttg acatctttgt ggacatagaa agttatttga caatagatga
    20041 tagaaaaggt taatagatga aagaatttaa agtaagtatc ttttggggtg aacagtgtgc
    20101 tgtttcatga gtttggtgac ccttcaaaac caattataat gctctttcca ggaacgatgt
    20161 gccactggaa agcgaatttt gagaaagtga ttccacgatt gctgtcagat ttttttgttc
    20221 ttgttgtttc gtatacagga tttgatggtg aggataggga ggattttcaa tcaattttgg
    20281 ctgaggttca aaagattgaa gagatgattc agcaaaatta tcaaggaaaa atttttgcag
    20341 cctatggctc atcacttggt ggaacgcttg tcgcacagct tgtggcacga aagaaagtga
    20401 taatgtcaaa agcaatcatt ggtagctcag attttgacca agagaatcat ctattggccc
    20461 ttttaaaggg aaaattgcta gtaatgctaa tgcacccttt tttgaaaaac gggtattttg
    20521 ttccaaaatg tgtgcaaagc tattttcaaa aagagtcttc taaagatccg tatgtgaggg
    20581 acattttttc tttcatgact ggtttgacat ttgtcagtaa acaatcactt ttcaatcaat
    20641 tctattcaga tttaatcacg cctttatcta atatgattga aaatgatgag actgaggtgc
    20701 atatttttta tgcggaaaaa atgggcgaga agtatttaaa acgctataaa aaacatttca
    20761 aaaatcctat tattcataga caaaattatc gtcacgaaga gcttttagca tcatatcctg
    20821 aaaaatggta tcaagctgtg atggcaattt gtaacattta ataaaaataa gagaaaaaag
    20881 gaaaagtaaa atgaacattg aaaatcttga aaaatggcat ttcgagctga ctgaggatgc
    20941 ctgcaatagt ttgcttgatt tggttttaaa aggtcagaaa agagcgacat caagtagctt
    21001 agcagccttt gaacttggtg atgaaactat gccaaaagaa ggagagttaa gtgtcattac
    21061 tgattgggat ggcaatcctc gttgtgtggt gagaacaaag aaattgcaca tccttcctta
    21121 tgaggaaatc acttatgacc ttgctaagct tgaaggcgaa gatgagacgt tagactcttg
    21181 gaaaagaagc cacgagcgtt tcttcactcg tgagggagag atgcttgggt atcacttttc
    21241 accacaaatg tcagttgtct ttgaagagtt tgaagttgta gaagttttgt agaaagtagg
    21301 catttgaata attttaatat ctgaggtgaa aatctcagat attttttatg aaaaaatcag
    21361 aatttttcct actgacagtt tttgatgatc ttagataagc gtatatcagc gtgtagcgct
    21421 tacattttag gcgattagtg ttttttggtc aaaatttcaa gtgggagccc ttagaggagc
    21481 aaaaaagggg caaatattgc aaatttttat ggtaatatcc ctagaattct aacttttggt
    21541 gtgataaaat ggtaacgtca gttctcgtaa gcgtctgaga acaaataaaa gtaggaggaa
    21601 aagatggacg cttttaagta tattaagcca aaactgttta gtactcttaa aaattattcg
    21661 ggtgcgcagt ttgcaaaaga ccttgttgcg gggattattg tggcaattat tgccttacca
    21721 ttgtcaattg ccttagcgat tgcatcaggt gttaatccag aacaaggtct ttatactgcc
    21781 gttgtcgcag gtttttttat ttcattttta ggtggtagcc gtgtccaaat cggtggacca
    21841 actgcagcat ttgttgttat tatctacggt atcattgctc aatatggtat ggcaggtctt
    21901 actattgcaa cattcttagc tggtatcatg atgattatca tggggcttct tcgttttgga
    21961 gatttgatta aattcatccc taaaacaatc acagttggat ttactttggg tattgctgtt
    22021 ggtatttttg ttggacaact taaagacttc tttggactaa gcatgggtgc agttccagct
    22081 gagtttgttg aaaaaatggt tgcatacgct caacatttaa atacaattca ctggccaaca
    22141 cttatgattg gtatgattgc attgctcatc caaatcttct ggcctcgtgt ctctcaaaaa
    22201 atccctggtt cacttgttgc tatcatcgtg acaacagcga ttgttgggtt tggtcacttg
    22261 tcagttaaaa caattggtga cttgtacact atcaaagctg gtttgccgac attcacaatg
    22321 cctgaattgt catttggtct tgttcgtcaa atgatttcac cagcttttac aattgcaatt
    22381 ttggcatcta tcgaatcact tctttcatgt gtggtttcag atggtatgat tggtagccac
    22441 caccgttcaa atgctgaatt ggttggacaa ggtgttggta acatgatgtc tgctttgttt
    22501 ggtggtattc ctgcaacagg tgcgattgct cgtacagcag ctaacgttaa aaatggtggt
    22561 cgtacaccga ttgctggtat gactcatgcc gtaactctac ttttaattct tttgttcttg
    22621 atgccatatg cgtcacttat tccaatgagt tgtttggctg ctattttgat tatggttgct
    22681 tataacatga gcggatggcg tacatttatt cacatgctta aaaaagcgcc taagagtgat
    22741 attgctgttt tggtgattac acttgtcttg acagtcttct ttgaccttgt tgttgccatc
    22801 gaattcggca tggttttggc tgccttccta ttcttaaaac gcatgtcaga tgttgctgcc
    22861 gttcgtcaat gggttgacaa agatagcctt gatgacgctg aactttctga aaacacagat
    22921 ttgaaacacg tgccaagcaa cacagttgtt tatgaaatct ttggttcatt gttcttcggt
    22981 gctgcaaatg actttcttaa ctttaaccat gaagaaggta aaaatgtctt gatccttcgc
    23041 atgcgcaatg tgcctgctat ggatatttca ggacttgaag ctcttgaaga aacacttgaa
    23101 atctgtcaaa aacgtggcat gacattgatt ctttctcacg tgaataaaca accttatcac
    23161 gtaatggaaa aagctggctt tgttgaaaaa gttggtcaag aaaacctttg tgaaaatatc
    23221 gatgcctcac ttaaacgtgc agcaagccta gcaaaataaa gatataaata gataacatcc
    23281 agcagaatct tctgctggat ttttttgatt atcctgaaga aataaaattt aatttttgtt
    23341 aattttgaaa tattctgtat ttttagaaaa tagtgtgtta taataccaaa catatcgaaa
    23401 gaaagtttat ggtaggagga aacttttatg gacaataagt ctactttaaa acgtgttgga
    23461 cttggagcgg taagcttggc ttcagttgct ttattggctg cgtgtggggg cggaaataaa
    23521 actgcagcta ataaaaacga gattaattgg tacacaccga ctgagatttt gacactggat
    23581 atttcaaaaa atactgacca atattctgcg ctagcaattg ggaactcatc aagtaaccta
    23641 cttcgtgtag ataaaaaagg tgaaccaaaa ccagacttgg caaaaagtgt cgaagtttct
    23701 gaggatggtt tgacttacac agcgactttg cgtgatggtt tgaaatggtc tgacggtagt
    23761 gacttgactg ctgatgattt tgtctacaca tggcaacgta tggttgatcc aaagacagct
    23821 tcagaatacg cttatttagc tgttgaatca catcttgaaa atgctgataa gattaatact
    23881 ggtgaaatct ctgatttgag tcaacttggc gttaaagctg atggtaataa aattaccttt
    23941 aagcttacaa gtccatgccc acaatttaag tattatctag ccttttctaa ctttatgcca
    24001 cagaaaaaag catttgttga aaaagaaggc gacaaatatg ctacaacttc taaagatcaa
    24061 atctattctg gaccatatac tatcaaaggt tggaatggaa gtgatggcag ctttacttta
    24121 gttaaaaata aatactattg ggatgctaag aacgttaaga ctgaaaaagt caatcttcaa
    24181 gcaatcaaaa aagcagatac tgccgttcaa atgtacaaaa acggtgagct tgataccgca
    24241 aatatctcag caacctcatc aatctataaa gcaaacaaga gcaacaaaga agcagttcca
    24301 gttccagaag ctcgaatgac ttacatcgtt tataacgaaa cgggctcagt tgcctctctt
    24361 gctaatgaaa aaattcgtca agcacttaac ttggcaacag accgtcaagg tgtcgtagaa
    24421 gctgctattg atactggttc aaaaccagcg acagcacttg caacaccagg tcttgcaaaa
    24481 ttaactgacg gtactgacct ttcaaaatac gttgaacctg gttataaata cgatgaaaaa
    24541 gaagcagcta aattgttcaa agaaggtctt gcagaacttg gtacagattc agtgaaattg
    24601 acagtaactg cagactctga tgatgctgtg acaaaagcag ctgttgatta catcaaacaa
    24661 agttgggaag aagctcttcc aggattgaag attgaagaaa aatttgtaac cttcaaacaa
    24721 cgtcttgaag atactaaaaa ccaaaacttt gaggttgcac tagtttcttg gggtggagat
    24781 tatccagaag gatcaacctt ctatggcttg ttctcatcaa cttcagcata caactatggt
    24841 aaagtatcta gtgacgaatt tgatgctgct tataacaaag cactcacaga agatgctttg
    24901 gatacagatg ctgctgcaga agattataag actgcagaaa aagttcttta cgaaggtgca
    24961 cactacaatc caatcttctt ccgtagtaca aaatggcttc aaaatccatc tcttaaagga
    25021 cttgttcgta attcaactgg cttgacagta gactttactt acgcttataa aaaataaaaa
    25081 ttagaaatac gttgaaaaat gcaaggttta tgtaaaagta taccttgctt ttttgatgat
    25141 atttatacca taaaatgaaa atgtatgtaa aatgatgtca gattttgtac aacggaataa
    25201 agtttgataa agtcgatagt ttgagtgata gaagttctaa tagtagctaa aaatgaaaga
    25261 tgtaaggcta cttcaaatgt gataaaacgg gttgtatttt tataaaaaac agataattta
    25321 tcctcttgtt gtataaaatt aaaagaaaat gatacaaaag ttaatctaaa atatgttttt
    25381 gaaattttaa ttaatttaca aattttctgt atttttagaa aatattgtgt tataatactt
    25441 tacataccga aagaaagtta tatggtagga ggatccatta tggagattaa atctttaaaa
    25501 cgtgtcggcc ttggagctgt cacattgttg tctgttgcta cactagcagc atgtggtgga
    25561 aataactcat catcaaaatc tgctagcaaa gatatcaatt ggttcgtgcc aactgaaatc
    25621 agtactcttg atatttctaa agtaactgat acttactcat caattgctat tggtaactca
    25681 ggaagtaacc ttctccgtgt tgataaagat ggaaaattgc aaccagattt ggctaaaagt
    25741 gttgatgttt cagaagatgg tttgacatac actgcgacat tgcgtgatgg tcttaaatgg
    25801 tcagatggta gtgatttgac tgcagaagat tttgtttaca catggcaacg tattgcagat
    25861 ccaaaaactg cttcagaata ttcttaccta gtatcagatg cgcatgtatt gaacgctgac
    25921 gaagttattg ctggtacaaa aggtcttgat gaacttggag ttaaggcaga cggaaacaaa
    25981 gttatcttta ctttgtctaa cccatctcca caatttatga gtcttc
//
