LOCUS       NZ_CP011665            24589 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 plasmid pSMg1-1, complete sequence.
ACCESSION   NZ_CP011665
VERSION     NZ_CP011665.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 529571)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 529571)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 529571)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 466209
            Orig. end                         :: 490798
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011665.1.
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24589
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="4"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24589
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24589
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14589](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14589
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(77..92)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            complement(420..917)
                     /locus_tag="M444_RS36710"
                     /old_locus_tag="M444_36695"
     CDS             complement(420..917)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008740893.1"
                     /locus_tag="M444_RS36710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36695"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_008740893.1"
                     /transl_table=11
                     /translation="MTFTSAAKPVLVRAAEAETLQDGATSLITLLADANATGGALTANR
                     ATLHKGSPGAPAHFHTRATEMFYVLGGSMRILLDDQVLTLGQGDFLTVPPTVPHAFAPA
                     PDSEAEMLVVFTPGMDRFDYYRLLERVYQGEASVQDIRDSSEQFDNHYFESPVWQRELA
                     RR"
     misc_feature    908..922
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            1162..1665
                     /locus_tag="M444_RS36715"
                     /old_locus_tag="M444_36700"
     CDS             1162..1665
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566596.1"
                     /locus_tag="M444_RS36715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36700"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_037792660.1"
                     /transl_table=11
                     /translation="MRTHHKTAIALAAALLTAVAAAVAQAAPAVGRGAAPSACRPANHT
                     AKITSAPASAGHHHYRVTLTAPRGYDPCALAGSPTDVRFSDHGSHTPVTAGRYGDQSAV
                     VTLGPGRPVHFDIQVPGDARQVRADEASFTLRGPDGPIPGASFAEGALMVAPGTLVGPV
                     EQGA"
     misc_feature    complement(1721..1735)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.04"
                     /tool="antismash"
     misc_feature    1728..1743
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    1941..1956
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            1971..2708
                     /locus_tag="M444_RS36720"
                     /old_locus_tag="M444_36705"
     CDS             1971..2708
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS36720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_36705"
                     /product="hypothetical protein"
                     /protein_id="WP_148639911.1"
                     /transl_table=11
                     /translation="MRSTSRRGVTTAAGVALAGVTLAMLPGSAQADDSWTSTVRIAKYT
                     AYLASQSAQGDTQAEETAQGFAALSKADKARFLDLIEDHAVMRKVFDPAEAPSALVGSS
                     QQVLAGGDVVVQHESLSGVDEASPHSSVALRASGYRDMWASYSITDRVMGVKVSRVTVR
                     TNYQVKGKDTTKVYPGSATHSLSVPGCSFSHSPVKEWISSAPADNAQSETIWSASCWGS
                     EWDKRERVWADYRGFVGGYLKDE"
     gene            complement(2743..>2949)
                     /locus_tag="M444_RS36725"
                     /old_locus_tag="M444_36710"
                     /pseudo=""
     CDS             complement(2743..>2949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020131221.1"
                     /locus_tag="M444_RS36725"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36710"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="PPGAPHTFANPGDRPAVMLSTFTPDLYLQYFRELRDGLGDGRRTL
                     TPQAAIDTMSRYATGPAAGLIRE"
     gene            2971..>3066
                     /locus_tag="M444_RS40535"
                     /pseudo=""
     CDS             2971..>3066
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014670311.1"
                     /locus_tag="M444_RS40535"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSQPPLSRAIKGLEAEAGAPPFARSPAGATLT"
     gene            complement(3123..4082)
                     /locus_tag="M444_RS36730"
                     /old_locus_tag="M444_36715"
     CDS             complement(3123..4082)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004952148.1"
                     /locus_tag="M444_RS36730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36715"
                     /product="phospholipase"
                     /protein_id="WP_234008857.1"
                     /transl_table=11
                     /translation="MRAPLALMAALCAVIGTTALTTTPAAAADQRHPIYAIAHRVDTLA
                     GVDAALKHGANSIEIDVCAWWNPNEWRAYHDCSSAGDNRLGPSFDSMIDRILSNANAGR
                     RLSLVWLDIKDPNYCGERENRGCSVAGLRDKAQRLTAAGIQVLYGFYEYHGGNTPDVGG
                     RGWQSLEGRLGSLEGITSTGTRDQVQGAFNRSGSGFPAGRRAMDYGDSDITKGFGNCTE
                     ATYNTCAELKKGAGDRDAGRLAATLSWTTTYNDPWYVDKLLGDGRVDGIIAGYGAFTGV
                     REYDDSWQCANSIGLIRDWVNRHGGTHRMAGPGDRLFH"
     misc_feature    4110..4123
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.85"
                     /tool="antismash"
     misc_feature    complement(4149..4162)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.0"
                     /tool="antismash"
     gene            4487..4936
                     /locus_tag="M444_RS36735"
                     /old_locus_tag="M444_36720"
     CDS             4487..4936
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS36735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_36720"
                     /product="hypothetical protein"
                     /protein_id="WP_037792656.1"
                     /transl_table=11
                     /translation="MREDSVVVAEFGALENSGGRPVRFAVLRGAGPEGTWLVEITPYLL
                     GMAGAEDLRNFARGILDTLSAGAGESDFFTLYKDTRNQVQAVIGFDEGLPYLIVDAYTE
                     FAGNRTGTSPSDEPVYAHMEAVSPSRADPAALESGARALLGALGV"
     gene            5148..6734
                     /locus_tag="M444_RS36740"
                     /old_locus_tag="M444_36725"
     CDS             5148..6734
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS36740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_36725"
                     /product="hypothetical protein"
                     /protein_id="WP_008740887.1"
                     /transl_table=11
                     /translation="MAALSYEILTDPVPLQTSGSDDAQTSVAGTVYIVVSNPTTDWVPW
                     YQIEVVLPCGKEAGDLTDRPDMIKTGIEPYAVRFGDVPKDEWDAGTRTFTVSAALGGLF
                     TPGDSMVLSLDGFPVSDKEGLVRLTVNEISGGDPGDGVRTHPLTLSLLKRAPKAPRNFR
                     PEEALVGGGENVVLVWDGPDTLTYTIEGPDGLSVPVPQRTGPDWRWSPGPDDAPLRDAT
                     YTLVATSPDGRQPGYFLTTTVAVRRPEFEAVTATQGLFAPRIEGTTDKGVIVLTEDGVE
                     VLAADGEPGLVSAGKADVEGVTTRWVRGRDAAAGWIEFPAAGLNVFRGEGDRKWGTVAA
                     DKADLNGINTAWVQGRDAAAGWIEFPAAGVNVFRGEGDRQWGTVAADKADLNDLLADRA
                     RVKDRLTLDGGLTVTDVLETQSGPSRLIVHGRLDAEGELSVNGELRASQSAEIAGAVVA
                     SDLTVRGKLRTNHEQFKLIVEGESLFREQANANGGLAVRNEHAGWLVHAKGEQVSIQGD
                     LRVHGAFRSDS"
     gene            6863..7000
                     /locus_tag="M444_RS42165"
     CDS             6863..7000
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS42165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158074271.1"
                     /transl_table=11
                     /translation="MPQLEIEFPAFAENWLEVESVPQIGRDAAEERAWVPAYWAAPAAA
                     "
     gene            7080..8648
                     /locus_tag="M444_RS42170"
                     /old_locus_tag="M444_36730"
     CDS             7080..8648
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04267.2"
                     /locus_tag="M444_RS42170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36730"
                     /product="HEXXH motif-containing putative peptide
                     modification protein"
                     /protein_id="WP_037792652.1"
                     /transl_table=11
                     /translation="MSVAAINNNSPESLECPESPEFLERPESQAVRRADRMLVDDRRFG
                     DSRSIEERNVARFSIGAELLAEHDPGHGPVLRRISRADREQLLPLLGDPVLRNAFEDDL
                     VKLENGVRSGFSFGALASRIPDEPAGLGPCERMATPHVRPWADHGSAWVWTEMFPADRV
                     PGELATRLRQLYDGSIEGGPSADPVVPGPEMCRALGRGARLLTALLPRVGPSVLGHVSV
                     VGFTRGESADGPLQSLSGGDPLPSAILMAPERLADPWTVAETLLHESVHLKLFDALRAG
                     ALLTDPERSVPIPWRQTPWRLIRVLVALHFYVHLLVFQEAVRNAAPELRAEFGRPPVGE
                     VVDEVTPGTEAARNGTFGTGLERVRYLAGYIRELPPGTLTPAGRQLMRWLGEVTAVLDP
                     EPPAAPEPPAAPGPAATPVTAPAAPAAPAATRDAGPEEAVPHRTAGILARPMPAHGELL
                     LADTGTCTLHWLNARSWLVYSLCDGRDVPSVQAEYARRTGTDAPAAASHVTACLEELRN
                     SGLLS"
     gene            8765..8947
                     /locus_tag="M444_RS41790"
                     /old_locus_tag="M444_36735"
     CDS             8765..8947
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="M444_RS41790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36735"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_037792650.1"
                     /transl_table=11
                     /translation="MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETAEAGFSNWYSCKS
                     TCVRECLGLSINGCN"
     CDS_motif       8765..8863
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETA"
                     /locus_tag="M444_RS41790_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8864..8947
                     /prepeptide="core"
                     /locus_tag="M444_RS41790_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="2.70"
                     /molecular_weight="2852.2"
                     /monoisotopic_mass="2850.3"
                     /core_sequence="EAGFSNWYSCKSTCVRECLGLSINGCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVLIEPIVRDLVMDDFDLDVRIAVSADFETA"
                     /leader_location="[8764:8863](+)"
                     /alternative_weights="2870.2"
     misc_feature    complement(9008..9020)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     gene            9027..10004
                     /locus_tag="M444_RS36755"
                     /old_locus_tag="M444_36740"
     CDS             9027..10004
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012888.4"
                     /locus_tag="M444_RS36755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36740"
                     /product="sulfotransferase domain-containing protein"
                     /protein_id="WP_037792648.1"
                     /transl_table=11
                     /translation="MSAERVLVISPRKSGTHLVQELLVHLGYRIYGEPVPPPEGRPDFS
                     IRERLAMAERYLDPGEFRALDPRRDREAFLRTTDQVWLQLAWAWQTRMAVAPLTHVEAV
                     APAAGFGPKMSPDIWTAPFSQTPPGIAWIFHSADIWRMDASFLAEWVNTGSPKVILNYR
                     DPRDVLLSLVDFFSRNNGLRFRRFPETAIFGPVLESIQDPAAKIDYALSDPAIPLLGDY
                     ESAISFLHHPNVCTVSFEELVGPQGGGGHQTQRDAVRRVAAWLDQDVDADAVAEELFTP
                     RSFTLNKGRAGRWREAFTPAHTERFEARFGHLLDTFGYDREVSR"
     gene            10001..11311
                     /locus_tag="M444_RS38895"
     CDS             10001..11311
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="M444_RS38895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_008740884.1"
                     /sec_met_domain="LANC_like (E-value: 2e-40, bitscore:
                     133.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISASLAGQARATAAMITSRLADPAHIEAAVAASTPDPNALGPRP
                     PSSLLAGDAGIALLLRHAGDAPHEEADRWRRAGHAALLRAVRDTREAPLTSAGIVTGSA
                     GLALAMAEFAATDHRYRPGLDGVHIGLADQTRRRLADGGPVGGPRFEDYDVLGGASGVL
                     GHLLTQAPDRTDPAPVHALIDDLVRFCTAESEGHEPRWVVPLEHYPLPPRTTREAHGFI
                     NLGMAHGIPGPLAALALAWKSGYRRPRMGEAIANTVAALSAAAVRDEFGVIWPGEIPVG
                     PDGRHTDEHHPARSAWCYGVPGIAVALLTAADALADRRLRNFAIEAIEADLRRVEATLD
                     RRSPSLCHGLAGLLSIAEVFARTTGSATARAFLPFLTEHLLSHCSADLPFGVQNREPPD
                     LKIDNPDFLCGAAGVAAALWTVSTPVSRGWQRALLIA"
     gene            11395..14589
                     /locus_tag="M444_RS36765"
                     /old_locus_tag="M444_36750"
     CDS             11395..14589
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="M444_RS36765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36750"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_037792646.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.8e-158,
                     bitscore: 523.5, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-11,
                     bitscore: 39.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.6e-35, bitscore:
                     117.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLYTPAGYFLLRTPTLPFTPYAQALDGTGAAGRDRIREVAGQPL
                     VRQALRVASDSLAEQLRKDARDDRTDASLLRYVSRMSSRPTPYGLFAQVAAGEFGPRTS
                     LTRTGARPAATRTRADMGWLEQLVQQIEDDRDVRPGLTVVLNPLLQRSHDRLTLPVSHS
                     LRPTDQRVSSVRITRAVETVLDRAATRPTWAELTARAARDFPAVPAARIDALLDRLWDL
                     RMLTSDLRPPMTHPLPETAVLDRLAGLAGAERYRGALGRTRDLAARADAAPPEHAERLL
                     AELQTYQRTLVPGHTESPLQLDARAALATDTTAAAAATVTDPAATLSAAVADAAADAAD
                     VLLRLGHHTRDTALAAYHEHFLDRYGSGAEIPVLELLNPETGLGAPDGYHFPARELPLE
                     LGPRPRPATGRSALTALAAAALHQGATEVELTDAFLAGLPSANGGGAGPRPRPGLDVLG
                     QLMAESRQDLDTGRWRFVLTTGAVRDGGRIGARFFDLLGEDFGRRMKRYAEAEEARCPG
                     VLFAELNYRPLHSRGGNIAIHPSVRSHEICVNTEPTAGVGQIGLDDVLVGATSERLYLR
                     SAAHDQELKVTQSHLFNWSTAPNVCRFLLEVSQDGWAALAEFEWGDLLEAADFLPRVTR
                     GRVVLKPARWRFGPGAPGFPAGLASGTPEAERFFEIFQKWRRDWHVPRWVNLAMLDNRL
                     LLDLDSSVCVAEIQRELRSTAPHKGGNLIMEEALFDPLRPQWLRDGAGRSYTAEIAVPL
                     LARNTAAGAAVPVAPATAVAAGRTAARRPALAKHQLPGGDWSHLKLYAAASRHEDLLTG
                     EVPRLVHGLREEGLIDRWFFIRYADPHPHLRIRVRRRPGAAPHAAMNRLVDWAGDLVGH
                     GPARDAALISYDRETERYGGPVALEALEAVFEAGSDMTTAVLALLRDRPGMELDVVGAL
                     ALHRLYEAWGHQDGAPADTAPHHTVEARDREAFRAVRTTLCDLVAPWDARPDARARQWA
                     PDLDRLLAIQDQAVRQAGDLVRRLARAGELTGTEQDVLGSLAHMQSNRLLGIDRTRELR
                     SHSFRALALRAVRGRP"
     aSDomain        11824..12090
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M444_RS36765_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="8.70E-13"
                     /identifier="RREFam001.1"
                     /label="M444_RS36765"
                     /locus_tag="M444_RS36765"
                     /protein_end="232"
                     /protein_start="143"
                     /score="39.8"
                     /tool="antismash"
                     /translation="VLNPLLQRSHDRLTLPVSHSLRPTDQRVSSVRITRAVETVLDRAA
                     TRPTWAELTARAARDFPAVPAARIDALLDRLWDLRMLTSDLRPP"
     gene            14586..16355
                     /locus_tag="M444_RS43960"
                     /old_locus_tag="M444_36755"
     CDS             14586..16355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="M444_RS43960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36755"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_008740882.1"
                     /transl_table=11
                     /translation="MTGQWRRVLALLWSISPRQILAVTAASLATALLPAAQVFLTALTV
                     QSVADALTSPAAADRGALRAGACLAALLVAGHLLGVLHANQEALLRSRLPDVLTLRIMA
                     KAGRLTLGQFEEPDTYDNLQRATREAAFRPLQVFTGMLTVVSAALSFLAVATVLLRESI
                     AMAAAICLAPVPAALAGLWFSRRTHAAHHAQAEGRRTLTYLEHLLTNDRTYKETRLFNL
                     VPLLLDRSRRLTDDFHATNRRIENGQARWTALLGLLSTGTTAAAVLLAVRSALHTGQVG
                     ALAGYVAGVAVIQAAVSALFTSGVQLYENGLFLRHLFGFLDMPEPAVREGTLALPPVLS
                     KGIEFREVTFTYPGQREPVLDGVSFTVPAGARAALVGSNGAGKSTLIKLLTRFYEPTGG
                     TILIDGRPLSDYSLQGLREGIGAIFQDYQEYEAPVRENIGFGKPALLDDDGRIREAAHR
                     VGALAFLDTLPEGIDTRLGRWFPGGRQLSGGQWQKVALARALVGEAPVLILDEPTAAID
                     AAAEADILDVLRTVGTGATSLLVAHRFSAVRTADHIVVLDGGRVLEQGSHEQLMESGGR
                     YASLFGLQAAGYR"
     gene            complement(16399..17085)
                     /locus_tag="M444_RS36775"
                     /old_locus_tag="M444_36760"
     CDS             complement(16399..17085)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523488.1"
                     /locus_tag="M444_RS36775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36760"
                     /product="response regulator transcription factor"
                     /protein_id="WP_008740881.1"
                     /transl_table=11
                     /translation="MTTYASVSHSPLHVAVVERNPLLRAGICAALTAAAGIEVVMDTGS
                     APGLGALVGAAAPDVILLDLDLPGSAALEVCRELMAGTGRRRAVLGMTGRGADAALVRS
                     ALLAGVRGCLAKDAGGPEVVGAVHMVARGLMVAGSPMDQVLSGLLTTGGRTAERQVLPE
                     LTRREREILDLVARGFDNRCIARTLTLADKTVRNHVSAVLGKIGVSSRGQAIVLAREAG
                     LGTSAR"
     gene            17178..20555
                     /locus_tag="M444_RS43965"
                     /old_locus_tag="M444_36765"
     CDS             17178..20555
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.4"
                     /locus_tag="M444_RS43965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36765"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_078489091.1"
                     /transl_table=11
                     /translation="MRSDRGAMFEYRILGPLDVRRAGRAVPVTAPKERDLITLLLLRAD
                     RTVPAEDLIDGLWGTTPPATARTTLQNYIKRLRRILQQPGTGHPETLVTRPGGYLLRLE
                     DAFLDLREFDGLVRAAAEATARGDDTTAAARLDAALSHWRGEALSGSRSQHLRQLEAPR
                     LEESRTVAFEQRVEAGLRLGMHAELIAGLRVEAARHPLRERLQAQLVLALYRSGRRGDA
                     LAAARQARDHLVRELGLEPGPHLARLHDRILADDPALMDPRPKAPAVDAAPGAPTPTAP
                     STPPGRPGPAGPDPAAAASLSVLPAQLPPSTMVFTGRAEALRRLDELLPTAGPQPSGAA
                     RIAQISGQGGVGKTALAVHWGHGRRNRFPDGQLYVNLRGHGGQRPLRPVDALGGFLEAL
                     GVPAREVPVSEDRCAARFRSLCAGRRLLVILDDASSEEQVRPLLPGSADCMVIVTSRRT
                     LAGLVARDGALPVPLPVLEPSEAERLLVNILGAGRVSREPGAAAALTAACARLPLAVGI
                     SAADLALHPERTLAEQVERLVAEDRLSALELPGDSHSALRTVFAMSYATLDPDAARMFG
                     LLGTMPGADITVRAAAALAGVTRERSQALLDDLTRSHLLDEGAVGRYAFHDLLRAYARE
                     RVLDEQPEDVRSAATDRLYAWYLANVDKAAKVIQPQMLRLGTYTDGADLSFATPEDAVG
                     WLDSERANVVAMVQRAAEHGPRAAAWGLADAFRPYLMHSSYTAEWLAVGEAGLAAAEAD
                     GNAVGQAAGHRILSSAYLVLGRYDDCVRHDLAAVELYHGQGHTSGEAAAYNSLSLAAWY
                     GGRLDDAVEYGNRGLAIARTLEDKVPELIISTNVCGILHEAGMLREAEEHFEGMIGGQA
                     VDQTSTTESHTFTNFAALLHDRGLPERAAELLAKAEAIRRRAGQAPSSLSYTLYWKAVM
                     ALQAGDRASALEHVEEGFSSAGGDIRAQAYLYVARGMLAERTGGHETALRSFQQARDLA
                     EQCASRKPELEALTGMARCNLRAGRVDTARSFAEELLKDATASGYRLFHGYALTLLAEI
                     ACEEGDPAEAQRRAGEAAAVQEANGHPRGQAEALIALARALRAAGDTEGARARVHQAAH
                     LWSGFAPRRAASILSLAD"
     gene            complement(20585..21046)
                     /locus_tag="M444_RS36785"
                     /old_locus_tag="M444_36770"
     CDS             complement(20585..21046)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS36785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_36770"
                     /product="hypothetical protein"
                     /protein_id="WP_008740879.1"
                     /transl_table=11
                     /translation="MSERDNAPAVETSLWSAVTLLDERGPAAARVAVEEVLSALPGRRG
                     RDWTAPQEARIRALVKGMDALRTLDRAPEGWWGRRRARRARRRLAVLMRVAGPKLVDEA
                     ALRCWKSARVLEVLKAFAAGRRDRAEVAEVLDRLRVVQRATYLDLGQAA"
     gene            complement(21216..21932)
                     /locus_tag="M444_RS36790"
                     /old_locus_tag="M444_36775"
     CDS             complement(21216..21932)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007497680.1"
                     /locus_tag="M444_RS36790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36775"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_008740878.1"
                     /transl_table=11
                     /translation="MAKDVVPEERRRRRRPTRQGTVLSERLIVETALRMVREHGSAGLS
                     ARRLGAALGADPSTLYRYFDGMDGLTLAIGEELIGRALAGWAPTGRWREDLRSLGLRIH
                     GAYLAHPQAALLTASRVTGRPREIAADEAILASLRGAGFGDVDAVRIYHAYIDQCLAFA
                     ALDAGALALSEKARDSDEERWESTYARLPAREYPNIAATAGLLAARMPHSAYPVALEML
                     LDAAERELGDGGERRG"
     gene            22035..23282
                     /locus_tag="M444_RS36795"
                     /old_locus_tag="M444_36780"
     CDS             22035..23282
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019057045.1"
                     /locus_tag="M444_RS36795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_36780"
                     /product="saccharopine dehydrogenase C-terminal
                     domain-containing protein"
                     /protein_id="WP_037796613.1"
                     /transl_table=11
                     /translation="MRVLLVGAGGVGSAITKIAARRDFFDHFVVADYDLTRAEAAVAAL
                     GAEERRFSACRVDASDESAVTRLLSERGCDVLMNATDPRFVMPLFNAALAAGSHYLDMA
                     MSLSRPHPDHPHRACGVKLGDEQFERAAEWEKSGRLALVGMGVEPGLSDVFARYAADHL
                     FDEIEEIGIRDGANLTVEGHDFAPSFNIWTTIEECLNPPVVYERERGWFTTEPFSEPEV
                     FDFPEGIGPVECVNVEHEEVLLVPRWVGARRVTFKYGLGDDFIGKLKTLHALGLDSTDR
                     VAVRGEDGREVRVSPRDVVAACLPDPATLGDRMTGKTCAGTWVKGTKDGLPREVYLYHV
                     VDNQWSMREYGSQAVVWQTAVNPVVALELLATGVWSQPGVLGPEALPPTPFLDLLTAYG
                     SPWAIREHPTTQPPRH"
ORIGIN
        1 gtggctccgg tcctcgcggc gaagggcctg cgcgagcgct ggacgggcgt ggtggaccag
       61 ctcaccttcg cggacctgat cgcctccggc gcctacgacc ggcacgtccg gcagatgcgc
      121 cagcgctacc gcgaccgccg gggccgcctg gtcgccgcgc tcgccgagca cgcgccgcac
      181 atcgaggtca ccgggatcgc ggcgggcctg cacgcggtgc tgcgcctgcc cccgggcacc
      241 gagaccgcgg ccgtggacgc cgcttccctg ctcggcctcg gactcgacgg gctcgccggc
      301 ttccggcatc ccgacaccgc cgaggccctg ttcgacgggc tggtcgtcgg ctacgcggcc
      361 ccgccggacc acgcgtacgc cgccgctctg gacgcgctct gcgcgatcct gccccccgtt
      421 cagcgacggg cgagttcccg ctgccagacc gggctctcga agtagtggtt gtcgaactgc
      481 tcggagctgt cacggatgtc ctgcaccgag gcctcgccct ggtacacgcg ctccagcagc
      541 cggtagtagt cgaaccggtc catccccggg gtgaagacga cgagcatctc ggcctcgctg
      601 tccggggccg gcgcgaaggc gtgcggcacg gtcggcggca cggtcaggaa gtcgccctgg
      661 ccgagcgtga ggacctggtc gtcgaggagg atccgcatgg acccgcccag tacgtagaac
      721 atctcggtcg cccgggtgtg gaagtgcgcg ggagcgccgg gcgaaccctt gtgcagcgtc
      781 gcccggttgg cggtcagcgc accgccggtg gcgttcgcgt cggcgagcag cgtgatcagg
      841 ctggtcgccc cgtcctgaag cgtctcggcc tcggcggcgc ggacgaggac gggcttcgcg
      901 gcgctggtga acgtcatggg cactccttgg tttcagtggt tccgccgacc ggtcactccc
      961 ggcgacacca ctgaatctag tctccggaaa gacccacgga agggtgcatt gaaggcccgg
     1021 aatcatgggt caattcaggg gcggtcaggg ccgtgacgat ctcgggacat tctctgacag
     1081 cgcaccgggg aacaggtcat accgaccagg gacccggcgg accacacccg cggggccgac
     1141 gtgcaaggca aggagtgctc cgtgcgcacc caccacaaga ccgccatcgc cctcgccgcc
     1201 gcgctgctga ccgcggtggc cgcggccgtc gcgcaggccg ccccggcggt gggacgcggc
     1261 gccgccccct cggcgtgccg tccggccaac cacaccgcga agatcacctc ggcgccggcc
     1321 agcgcggggc accaccacta ccgcgtcacc ctgaccgcgc cgcgcggcta cgacccctgt
     1381 gcgctggccg gttcgccgac cgacgtgcgg ttctccgacc acggctcgca caccccggtc
     1441 accgccggcc gctacggcga ccagagcgcc gtggtcacgc tcggccccgg ccgcccggtg
     1501 cacttcgaca tccaggtccc gggcgacgcc cgtcaggtcc gcgcggacga ggcgtccttc
     1561 acgctccgtg gcccggacgg gccgatcccg ggtgcctcct tcgccgaggg cgcgctgatg
     1621 gtcgcccccg gcaccctcgt cggcccggtg gaacaaggcg cctgaccgcg accgagcggg
     1681 agaaatcggg cttcgcggcc gattattcgg attcgccaat tccgtatatt gcgaagcctt
     1741 tgccgtggcg ttcgtcttaa ctcaggtcta cctcaaatcc cggaagatcg attgacgcgt
     1801 cgcgtcctcc ccgtgcagtc tttgcgaagc gcggcccggc ccaggggaat gaaagagccg
     1861 gggcgcgcaa cacgggggga acgggggatt tgcagggtgt acattcatgc cctttcccct
     1921 ttcctgctcg aacggcttcg agtggtatgg acctaagggg aaagaacgtt atgcgctcca
     1981 cttccagaag aggtgtcacc acggccgccg gcgtcgctct cgccggagtg accctggcca
     2041 tgctgccggg ctcggcccag gccgacgact cctggacctc gaccgtacgg atcgccaagt
     2101 acacggccta cctcgcgtcg cagtcggccc agggggacac gcaggccgag gagaccgccc
     2161 agggattcgc cgccctctcg aaagccgaca aggcccgctt cctcgacctg atcgaggacc
     2221 acgcggtgat gcgcaaggtc ttcgacccgg ccgaggcccc gtccgcgctc gtgggctcgt
     2281 cgcagcaggt gctggccggc ggcgacgtcg tggtgcagca cgagtccctc agcggcgtcg
     2341 acgaggcctc gccccacagc tccgtggcgc tcagggcctc cggctaccgg gacatgtggg
     2401 cctcgtactc gatcaccgac agggtcatgg gtgtcaaggt ctcgcgggtc acggtgcgga
     2461 ccaactacca ggtgaagggc aaggacacca cgaaggtgta cccgggcagt gcgacccatt
     2521 ccctttccgt gccgggatgc tctttctccc acagcccggt gaaggaatgg atttcctctg
     2581 cgccggccga caatgcccag agcgagacca tttggtcggc atcgtgctgg ggcagcgaat
     2641 gggacaagcg ggagcgggtc tgggccgact accgcggctt cgtgggcggt tacctcaagg
     2701 acgagtaaac ggaaatgccg gtgaattctc cttcaggtga attcactctc ggatgaggcc
     2761 ggcggcgggc ccggtcgcgt agcggctcat ggtgtcgatg gcggcctgcg gcgtcagcgt
     2821 ccgccggccg tcgccgagcc cgtcccgcag ctcccggaag tactgcaggt acaggtccgg
     2881 ggtgaaggtg ctgagcatga cggcgggccg gtcgcccggg ttggcgaagg tgtgcggggc
     2941 gccgggcgga aggccgccgc ccgactgcac atgagccagc cgccgctgag ccgggcgatc
     3001 aaggggctgg aggccgaggc cggggccccg ccgttcgccc gctcacccgc cggcgccacg
     3061 ctgacgcgat gtcgtgcgct cgcgcgggga agcgcacgac atcgcggggg acaggcccgt
     3121 gcctagtgga acagacggtc cccggggccg gccatgcgat gcgtgccgcc gtggcggttc
     3181 acccagtcac ggatgaggcc gatcgagttg gcgcactgcc agctgtcgtc gtactcgcgc
     3241 acccctgtga aggccccgta gcccgcgatg atgccgtcca cgcgcccgtc gcccagcagc
     3301 ttgtccacgt accacgggtc gttgtaggtg gtcgtccagg acagcgtggc cgcgagccgt
     3361 ccggcgtcac ggtccccggc gcccttcttc agctccgcac aggtgttgta ggtggcctcc
     3421 gtgcagttgc cgaacccctt ggtgatgtcg ctgtcgccgt agtccatcgc ccggcggccg
     3481 gccgggaacc cggaaccgga ccggttgaag gcaccctgga cctggtcgcg ggtaccggtc
     3541 gaggtgatcc cctccaggct gccgagccgg ccttccagac tctgccagcc ccggccgccc
     3601 acgtccgggg tgttgccgcc gtggtactcg tagaacccgt acagcacctg gatcccggcg
     3661 gccgtcagcc gctgcgcctt gtcgcgcagt ccggcgacgc tgcacccgcg gttctcccgc
     3721 tccccgcagt agttcgggtc cttgatgtcc agccagacca gcgacagccg gcgccccgcg
     3781 ttggcgttgg acagaatgcg gtcgatcatg ctgtcgaagc tggggcccag ccggttgtca
     3841 ccggccgagg aacagtcgtg gtaggcccgc cattcgttcg ggttccacca ggcacagacg
     3901 tctatctcga tgctgttggc gccgtgcttg agggccgcgt ccacaccggc cagggtgtcg
     3961 acgcggtgcg cgatggcgta gatcgggtga cgctgatcgg ccgctgccgc cggggtcgtc
     4021 gtgagcgcgg tggtaccgat gaccgcgcac agggccgcca tcagcgccaa gggagcccgc
     4081 acccgtgaac cggcagcacg cctgaggtga gtggtcaaga aaactccccg tcatgtcggt
     4141 gtcctgatcg gacatttgtt ctggtcccgc acatgctggc acgcgataaa tgcatgatga
     4201 atggacctgg tggaaggcag ccacggagtg gcgggaaccc gcctccggcc gttcttgacc
     4261 agcccctcgg cccggatcgc gtacgccatg ctcgacaact cctcgtcagt tcctcgttct
     4321 cgacgcccca gaccctgccg cccctccctg acaccccccg gccaccccgc tgacagcccc
     4381 cgccgaaccc tgtcagcccc tgtcagcgcc ggggcccggc ccgcccaggt accgtcgtcc
     4441 cgtgaacggg gacatgggca ggggagtgac cgcggaagtg cgcgctatgc gggaagacag
     4501 cgtggtcgtg gcggagttcg gcgcgctgga gaacagcggg ggacgcccgg tccggttcgc
     4561 ggtcctgcgc ggcgccgggc cggagggcac ctggctggtg gagatcaccc cgtacctgct
     4621 cggtatggcg ggagccgagg acctgcggaa cttcgcccgc ggcatcctcg acaccctctc
     4681 ggccggggcc ggcgaatccg acttcttcac cctgtacaag gacacccgca atcaggtgca
     4741 ggcggtcatc ggcttcgacg aggggctgcc ctacctcatc gtcgacgcct ataccgaatt
     4801 cgccgggaac cgcaccggta cctcgccgag cgacgagcct gtgtacgccc acatggaggc
     4861 cgtcagcccc tcccgggccg accccgcggc cctcgaatcc ggcgcccgcg ccctgctggg
     4921 cgcgctcggg gtctgacgag cgggagccgc ccttcgaacg gggggcgatt tcggatcacc
     4981 tgcgtgccgt gccggattcg gtcccgttct ggccattgcc cccctgtttc gcgccggtca
     5041 tggcgtatcg gggttttcgc ggggtccgga tggagagcgc tccgtgcggc ggggaccgcg
     5101 tccgtggggg gcgagcgccc gccagtcgaa caagggggtt ttgagcgatg gctgctctga
     5161 gctacgagat ccttaccgac ccggtaccgc tccagacgtc cgggtcggac gacgcccaga
     5221 cgtccgtggc gggcacggtg tacatcgtcg tctccaatcc gacgacggac tgggtgccct
     5281 ggtaccagat cgaggtggtc ctgccctgcg ggaaggaggc cggggacctt acggaccggc
     5341 cggacatgat caagaccggg atcgagccct acgcggtccg gttcggggac gtaccgaagg
     5401 acgagtggga cgcggggacc cgcaccttca cggtctccgc cgccctcggc gggctgttca
     5461 ccccgggtga ttcgatggtc ctgtcgctgg acgggttccc cgtctccgac aaggagggcc
     5521 tggtccgcct cacggtgaac gagatctcgg gcggggaccc gggggacggg gtgcgcaccc
     5581 accccctgac cctgagcctg ctgaagcgcg cgccgaaggc accgcgcaac ttccgcccgg
     5641 aggaagccct ggtgggcggg ggcgagaacg tggtcctggt gtgggacggc cccgacaccc
     5701 tgacctacac gatcgagggc ccggacggcc tctccgtacc cgtcccgcaa cgcaccgggc
     5761 ccgactggcg gtggtcgccc ggcccggacg acgcacccct gcgggacgcc acctacaccc
     5821 tggtggccac ctccccggac ggacggcagc ccggctactt cctcacgacc accgtcgccg
     5881 tgcgcaggcc cgagttcgag gccgtcaccg ccacccaggg cctcttcgcg ccccggatcg
     5941 agggcaccac ggacaagggc gtgatcgtcc tgaccgagga cggcgtcgag gtcctcgccg
     6001 ccgacggcga acccggcctg gtctcggccg ggaaggccga cgtggagggc gtgaccacac
     6061 ggtgggtgcg gggccgcgac gccgccgccg gctggatcga gttccccgcc gccgggctga
     6121 acgtcttccg gggtgagggc gaccgtaagt gggggaccgt cgccgccgac aaggccgacc
     6181 tcaacggcat caacaccgcc tgggtgcagg gccgggacgc cgccgccggg tggatcgagt
     6241 tcccggccgc cggggtcaac gtgttccggg gcgaggggga ccggcagtgg gggaccgtgg
     6301 cggccgacaa ggccgacctc aacgacctcc tcgccgaccg ggcacgggtc aaggaccggc
     6361 tcaccctgga cggcgggttg acggtcacgg acgtactgga gacacagagc gggccgtccc
     6421 ggctgatcgt ccacggccgg ctggacgccg agggcgagct gagcgtcaac ggcgagctgc
     6481 gggcctcgca gagcgccgag atcgccggcg cggtcgtggc gagcgacctg acggtccggg
     6541 gcaagctgcg gaccaaccac gagcagttca agctcatcgt ggagggcgag tcgctcttcc
     6601 gcgagcaggc gaacgccaac ggcgggctcg cggtgcgcaa cgagcacgcg ggatggctgg
     6661 tgcacgccaa gggagagcag gtctcgatcc agggagacct gcgggtccac ggcgcgttcc
     6721 gctcggactc ctgaccccgg ggggaggccg caccgcccgc cgggtcggga caattccggg
     6781 acggccgccc catgattgcg ggacggtatt ccggtcattc tggcggggtt cgcccaccag
     6841 ggcgacggaa aaggagtgac cgatgccgca gctggagatc gaattccctg ccttcgccga
     6901 gaactggctt gaggtggaaa gcgtcccgca gatcgggcgg gacgccgccg aggagcgtgc
     6961 gtgggttccc gcgtactggg cagcgcccgc cgctgcctga cgcagcaggc cgggggtggc
     7021 atcgatgcga tgccaccccc ggccgtcctt tttctcacct ccgcacgaac ggtggcccga
     7081 tgtctgtcgc tgcaatcaac aacaattccc cggagtccct ggaatgcccg gaatccccgg
     7141 agttcctgga acggccggaa tcccaggcgg tccggcgcgc ggaccgcatg ctggtggatg
     7201 accgcaggtt cggcgattcc cgctccatcg aggagcggaa cgtcgcccgg ttctccatcg
     7261 gcgcggaact cctcgcggag cacgatccgg gccacgggcc ggtgctccgc cgcatctccc
     7321 gggccgaccg ggagcaactg ctgccgctcc tcggcgaccc cgtcctgcgc aacgccttcg
     7381 aggacgacct ggtcaagctg gagaacgggg tcaggtccgg cttcagcttc ggggcgctgg
     7441 cgtcgcggat ccccgacgaa ccggcgggac tcggcccgtg cgagcgcatg gcgaccccgc
     7501 acgtacggcc gtgggcggac cacggctccg cctgggtctg gaccgagatg ttcccggccg
     7561 accgcgttcc gggggagctg gccacccggc tgcggcagtt gtacgacggc agcatcgagg
     7621 gcggcccctc cgcggacccc gtcgtgcccg gccccgagat gtgccgggcg ctgggccgag
     7681 gcgcgcggct gctcacggcg ctcctgccgc gggtcgggcc cagcgtgctc ggccacgtgt
     7741 cggtggtcgg cttcacccgg ggggagtcgg cggacggccc gctgcagtcc ctgtccggcg
     7801 gcgacccgct gccctcggcg atcctgatgg ccccggagcg gctggcggat ccctggacgg
     7861 tcgcggagac gctgctgcac gagagcgtgc acctcaagct gttcgacgcg ctgcgggcgg
     7921 gcgccctgct cacggatccc gagcgctccg tgccgatccc gtggcggcag acgccgtggc
     7981 gcctcatccg cgtcctggtg gcgctccact tctacgtgca cctgctggtc ttccaggagg
     8041 ccgtccgcaa cgccgccccg gaactgcggg cggagttcgg ccggccgccc gtgggtgagg
     8101 tcgtcgacga ggtgaccccg ggcaccgagg ccgcgcggaa cggcaccttc ggtaccggcc
     8161 tggagcgggt ccgctacctc gccggctaca tacgcgagct gcctccgggc accctcaccc
     8221 ccgcgggccg gcagctgatg cgctggctgg gcgaggtcac ggcggtgctc gaccccgagc
     8281 cgcccgccgc ccccgagccg cccgccgccc ccggtcccgc cgcgacaccc gtcacggctc
     8341 ccgccgcccc ggccgcgccc gcggcaacgc gcgacgccgg cccggaggaa gccgtaccgc
     8401 accgcaccgc cggcatcttg gcccgtccga tgcccgccca cggtgaactg ctcctcgccg
     8461 acaccgggac gtgcaccctg cactggctca acgcccgctc atggctcgtc tactcgctgt
     8521 gcgacgggcg cgatgtgccc tccgtacagg cggagtacgc ccgccggacc ggtaccgacg
     8581 cgccggccgc cgcctcgcac gtcacggcct gcctcgaaga actgaggaat tccggactgc
     8641 tttcctgaga aatgtcccgc acgggggtcg ggacatttca gggacagcgg catcaggaat
     8701 ccgggacacc agccgggtga agatatgact gtccgaatcg gacaccacca gaaggagaaa
     8761 tgaaatgact gctgtcctca tcgagccgat cgtacgggat ctcgtcatgg acgacttcga
     8821 cctcgacgtc cgcatcgccg tcagtgcgga cttcgagacc gccgaggccg gcttcagcaa
     8881 ctggtactcc tgcaagagca cctgcgtccg ggaatgtctc ggcctttcca tcaacggttg
     8941 caactgatct cgcgggacaa gtgaattcgg gcggcctgcc ggttccgggc gggccgcccg
     9001 ttcgtctttg gaaagggcaa accgaagtgt cggcagagcg ggtcctcgtc atatctccca
     9061 ggaagtccgg aacccatctg gtccaggaac tcctggtcca cctcgggtac cggatctacg
     9121 gggagcccgt acccccgccc gagggccggc cggacttcag catccgcgag cggctcgcca
     9181 tggcggagcg gtacctcgac cccggggagt tccgggcgct cgacccccgc cgggaccggg
     9241 aggccttcct gcgcaccacc gaccaggtct ggctccagct ggcctgggcc tggcagacgc
     9301 ggatggcggt ggcaccgctg acccatgtgg aggccgtggc tcccgccgcc gggttcggcc
     9361 cgaagatgag cccggacatc tggacggccc cgttctcgca gaccccgccc ggcatcgcct
     9421 ggatcttcca ctccgccgac atctggcgga tggacgcgtc cttcctcgcc gagtgggtga
     9481 acaccggttc ccccaaggtg atcctgaact accgggaccc ccgcgacgtc ctgctctcgc
     9541 tggtcgactt cttctcgcgg aacaacggcc tgcggttccg gcggttcccg gagacggcga
     9601 tcttcggccc ggtcctggaa tccatccagg accccgcagc caagatcgac tacgcgctgt
     9661 ccgaccccgc gatacccctc ctcggcgact acgagtcggc catcagcttc ctgcaccacc
     9721 ccaacgtgtg cacggtctcc ttcgaagaac tcgtcggccc ccagggcgga ggcggccacc
     9781 agacccagcg cgacgccgtc cgccgggtcg ccgcgtggct ggaccaggac gtcgacgcgg
     9841 acgcggtggc ggaggaactc ttcacccccc gctccttcac cctgaacaag ggccgggccg
     9901 gccggtggcg cgaggcgttc accccggcgc acaccgaacg cttcgaagcc cgcttcggcc
     9961 acctgctgga caccttcggc tacgaccgcg aggtgtcccg gtgatctccg cgtccctcgc
    10021 cgggcaggcg cgcgccaccg cggccatgat cacctccagg ctcgcggacc ccgcccacat
    10081 cgaggcggcg gtggccgcct cgaccccaga ccccaacgcc ctggggccgc gcccgccgag
    10141 ctccctgctc gccggggacg ccgggatcgc gctgctgctc cgccacgccg gcgacgcgcc
    10201 gcacgaggag gcggaccggt ggcgccgcgc cggccacgcg gcgctgctcc gggcggtccg
    10261 cgacacgagg gaggcacccc tcaccagtgc cgggatcgtc accggatcgg ccggactggc
    10321 cctcgccatg gccgagttcg ccgcgaccga ccaccgctac cggcccgggc tggacggtgt
    10381 gcacatcgga cttgccgacc agacccgccg acggctcgcc gacggggggc cggtgggcgg
    10441 cccccggttc gaggactacg acgtgctcgg cggcgcctcg ggcgtactcg gccacctgct
    10501 gacccaggcg cccgaccgca cggaccccgc gcccgtccac gccctgatcg acgacctggt
    10561 ccgcttctgt acggcggaga gcgaaggaca cgaaccccgc tgggtcgtcc cgttggagca
    10621 ctacccgctg ccgccccgca ccacgcggga ggcccacggc ttcatcaacc tgggcatggc
    10681 ccacggcatc ccgggacccc tcgccgcgct cgccctcgcc tggaagtccg gctaccggcg
    10741 cccccgtatg ggcgaggcca tcgccaacac cgtcgcggcg ctctccgcgg ccgcggtccg
    10801 ggacgagttc ggcgtcatct ggcccggcga gatcccggtg ggacccgacg gccggcacac
    10861 cgacgagcac catcccgccc gctccgcctg gtgctacggc gttcccggca tcgccgtcgc
    10921 cctgctcacc gctgccgacg cgctcgccga ccggcggctg cgcaacttcg ccatcgaggc
    10981 gatcgaagcg gacctgcggc gcgtcgaggc gacgctggac cgccgctcgc cctcgctctg
    11041 ccacggcctc gccggactcc tctcgatcgc cgaggtgttc gcccgtacca ccggcagcgc
    11101 gacggcgcgg gcgttcctcc ccttcctcac cgagcacctc ctgtcccact gctcggcgga
    11161 cctgccgttc ggcgttcaga accgggaacc cccggatctg aagatcgaca acccggactt
    11221 cctgtgcggt gcggccggcg tggccgccgc cctgtggacc gtgtccaccc cggtctcccg
    11281 cggctggcag cgcgccctgc tgatcgcctg aagccggacc ggaccggacc ggaccggttc
    11341 ggttcggtcc gcgcacccca ccccctctga ccccgcgtga gaacgagcga cccgatgaac
    11401 ctgtacacgc ccgcgggata cttcctcctg cgcaccccca ccctgccctt caccccgtac
    11461 gcgcaggccc tcgacggcac gggagcggca ggccgcgacc ggatcaggga ggtggccggc
    11521 cagccgctgg tccgccaggc cctgcgggtg gccagcgaca gcctcgcgga gcagctgcgc
    11581 aaggacgccc gggacgacag gacggacgcg tccctgctgc gctacgtgtc ccggatgagc
    11641 tcccggccca cgccgtacgg actgttcgcc caggtcgccg cgggggagtt cgggccgcgg
    11701 acgtccctca cgcgcaccgg tgcgcggccc gcggccaccc ggacccgggc ggacatgggc
    11761 tggctcgaac agctcgtcca gcagatcgag gacgaccggg acgtccgccc cggactgacg
    11821 gtggtcctca acccgttgct ccagcgcagc cacgaccgcc tcacgcttcc ggtttcccac
    11881 agcctccggc cgaccgacca gcgggtcagc agcgtccgga tcacccgggc cgtcgaaacc
    11941 gtcctggacc gcgccgccac ccggcccacc tgggccgagc tgaccgcccg cgccgcgcgg
    12001 gacttccccg ccgtgccggc ggcccggatc gacgccctcc tcgaccggct gtgggacctg
    12061 cgcatgctga cgagcgacct gcggcccccg atgacccacc cgctgcccga aacggcggtg
    12121 ctcgaccggc tggccgggct ggccggcgcc gagcggtacc gcggcgcgct ggggcgcacc
    12181 cgcgatctcg ccgcccgcgc ggacgccgcg ccgcccgaac acgccgagcg gctcctcgcg
    12241 gaactccaga cgtaccagcg gaccctggtg cccggccaca cggagagccc gctccaactc
    12301 gacgcccgcg ccgcactcgc caccgacacc accgcagccg ctgccgccac cgtcaccgac
    12361 cccgccgcca ccctctccgc cgcggtggcg gacgccgccg cggacgccgc cgacgtcctg
    12421 ctccgcctgg gccaccacac ccgggacacc gccctcgccg cctaccacga gcacttcctc
    12481 gaccggtacg gaagcggcgc cgagatcccc gtactcgaac tgctgaaccc cgagaccggc
    12541 ctcggcgccc ccgacggcta ccacttcccg gcccgcgaac tcccgctgga gctcggcccg
    12601 aggccccggc ccgccaccgg gcgcagcgcg ctgaccgccc tcgccgcggc cgccctgcac
    12661 cagggcgcga ccgaggtcga gctgaccgac gcgttcctcg cgggcctgcc gtcggcgaac
    12721 gggggcggcg ccggaccgcg gccccgcccc ggcctcgacg tcctcgggca gctcatggcc
    12781 gagagccggc aggacctgga caccggccgg tggcggttcg tcctgaccac cggggcggta
    12841 cgggacggcg gccggatcgg cgcccggttc ttcgacctgc tgggcgagga cttcggccgg
    12901 cggatgaagc ggtacgccga ggccgaggag gcccgctgtc ccggcgtgct cttcgccgag
    12961 ctcaactacc gcccgctgca ctcccgcggc ggcaacatcg ccatccaccc gtcggtgcga
    13021 agccacgaga tctgcgtcaa caccgaaccc accgcgggcg tcgggcagat cggcctggac
    13081 gacgtcctgg tcggtgcgac gtcggagcgc ctctacctcc gctccgccgc ccacgaccag
    13141 gagctgaagg tcacccagtc ccacctcttc aactggagca ccgcacccaa cgtctgccgg
    13201 ttcctcctgg aggtctccca ggacggctgg gcggcgctcg ccgagttcga atggggcgac
    13261 ctgctggagg ccgccgactt cctgccccgc gtcacccgcg gccgcgtcgt cctcaaaccc
    13321 gcccgctggc ggttcggccc cggcgcaccg ggcttcccgg ccggcctggc gtccggcaca
    13381 ccggaggcgg aacgcttctt cgagatcttc cagaagtggc gccgcgactg gcacgtcccc
    13441 cgctgggtca acctggccat gctggacaac cggctgctcc tcgacctcga cagctccgtc
    13501 tgcgtcgccg agatccagcg ggagctgcgc tccaccgcac cccacaaggg cggcaacctc
    13561 atcatggagg aggccctctt cgaccccctg cgcccccagt ggctccgcga cggggcgggc
    13621 cgctcgtaca ccgccgagat cgcggtgccg ctgctcgccc ggaacacggc cgccggcgcc
    13681 gcggtgcccg tcgcaccggc cacggccgtc gccgccggcc gcaccgcggc gaggaggccc
    13741 gcgctcgcca aacaccagct cccgggcggg gactggagcc acctcaagct ctacgccgcc
    13801 gcctcccggc acgaggacct gctcaccggt gaggtccccc ggctcgtcca cggcctccgc
    13861 gaggagggcc tgatcgaccg ctggttcttc atccgctacg ccgaccccca cccgcacctg
    13921 cggatccggg tgcggcgccg ccccggggcc gcaccccacg cggccatgaa ccggctggtc
    13981 gactgggccg gcgatctcgt cggccacgga ccggcgcgcg atgccgccct gatctcgtac
    14041 gaccgggaga ccgagcgcta cggcggaccg gtggccctcg aagcgctgga ggccgtcttc
    14101 gaggcgggca gtgacatgac cacggcggta ctggcactgc tgcgcgaccg gcccggcatg
    14161 gagctcgacg tcgtcggcgc cctggccctg caccggctgt acgaggcgtg gggacaccag
    14221 gacggcgccc cggccgacac ggcaccgcac catacggtcg aggcccgtga ccgcgaggcc
    14281 ttccgcgccg tacgcaccac gctgtgcgac ctcgtggccc cctgggacgc ccgccccgac
    14341 gcccgcgccc ggcagtgggc ccccgacctc gaccgcctcc tcgccatcca ggaccaggcc
    14401 gtacggcaag ccggcgacct ggtacgacgg ctcgcacggg cgggggagct gaccggcacc
    14461 gaacaggacg tcctcggcag cctcgcccac atgcagagca accggctcct gggcatcgac
    14521 cgcacccggg aactgcggag ccacagcttc cgggcgctgg cgctgcgcgc cgtacggggc
    14581 cggccgtgac cggccagtgg cgacgggtcc tcgcactgct gtggtccatc agcccccggc
    14641 agatcctcgc ggtcaccgcg gcgtcgctcg ccaccgccct cctgcccgcc gcacaggtgt
    14701 tcctcaccgc cctcaccgtg cagtccgtgg ccgatgccct gacctccccg gcggccgccg
    14761 accggggcgc gctgcgggcc ggggcctgcc tcgccgcgct cctggtggcc gggcacctcc
    14821 tgggggtcct gcacgcgaac caggaggcgc tgctgcgcag ccgcctcccg gacgtgctca
    14881 ccctgcggat catggcgaag gcggggcggc tgacgctcgg ccagttcgag gaaccggaca
    14941 cctacgacaa cctccagcgc gccacccgcg aagcggcgtt ccgcccgctc caggtgttca
    15001 ccggcatgct caccgtcgtc tcggccgccc tctccttcct ggcggtcgcg accgtcctgc
    15061 tgcgcgagag catcgccatg gcggcggcga tctgcctcgc ccccgtcccc gccgccctgg
    15121 caggtctgtg gttcagccgc cgcacccacg cggcccacca cgcccaggcc gaaggacgcc
    15181 gcacgctgac ctacctcgaa cacctcctca ccaatgaccg cacctacaag gagacccgcc
    15241 tcttcaacct ggtgccgctg ctcctcgacc ggtcacggcg gctcaccgac gacttccacg
    15301 ccaccaaccg gcggatagag aacggccagg cccggtggac cgccctgctg ggactgctca
    15361 gcaccggcac caccgccgcc gccgtcctgc tggccgtgcg gtccgcgctg cacaccgggc
    15421 aggtcggtgc gctcgccgga tacgtcgcgg gcgtcgccgt catccaggcc gccgtgtccg
    15481 ccctgttcac cagcggcgtc cagctctacg agaacgggct cttcctgcgg cacctgttcg
    15541 gcttcctgga catgcccgaa cccgccgtcc gggagggcac gctcgccctg ccgcccgtac
    15601 tgtcgaaggg catcgagttc cgcgaggtca ccttcaccta cccgggacag cgcgaacccg
    15661 tcctcgacgg cgtctccttc accgtgcccg ccggcgcccg cgccgctctc gtgggcagca
    15721 acggcgccgg gaagtccacc ctgatcaagc tgctgacccg gttctacgaa cccaccggcg
    15781 ggacgatcct gatcgacgga cggcccctga gcgactactc gctccagggc ctgcgggaag
    15841 gcatcggcgc catcttccag gactaccagg agtacgaggc cccggtccgc gagaacatcg
    15901 gcttcggcaa gcccgccctg ctcgacgacg acgggcggat ccgggaggcc gcccaccggg
    15961 tcggagccct cgccttcctc gacaccctcc ccgagggcat cgacacccgg ctcggccgct
    16021 ggttcccggg cggcagacag ctctccggcg gtcagtggca gaaggtggcc ctggcccggg
    16081 cgctcgtcgg cgaggccccc gtactcatcc tcgacgagcc gacggcggcc atcgacgccg
    16141 ccgccgaggc ggacatcctc gacgtcctgc ggaccgtggg cacgggggcg acctccctgc
    16201 tggtcgccca ccgcttctcg gccgtccgga ccgccgacca catcgtggtg ctcgacgggg
    16261 gcagggtcct cgaacagggc tcccacgaac agctcatgga gtccggcggc cggtacgcgt
    16321 cgctgttcgg cctccaggcg gccggatacc gctgaacggg cggggcgggc gggcggcgga
    16381 ggcgggggag ggggcgcgtc agcgggcgga cgtccccagc cccgcctccc gggccagcac
    16441 gatggcctgg ccccggctcg acacaccgat cttgccgagc acggcggaca cgtggttgcg
    16501 taccgtcttg tccgccagcg tcagcgtccg ggcgatgcac cggttgtcga acccccgcgc
    16561 caccagatcg aggatctccc gctcccggcg ggtcagttcc ggcaggacct gccgctccgc
    16621 cgtccggccc cccgtcgtca gcagcccgct cagcacctgg tccatcggcg atccggcgac
    16681 catgagcccc cgcgcgacca tgtggacggc gccgaccacc tccggtccgc ccgcgtcctt
    16741 ggccagacac cccctcaccc ccgcgagcag ggcggaccgc accagggccg cgtccgctcc
    16801 ccgccccgtc atgcccagca ccgccctgcg ccgccccgta cccgccatca gctcgcggca
    16861 cacctccagg gcggcggacc ccggcaggtc cagatcgagc aggatcacat cgggcgccgc
    16921 ggcgcccacc agcgcgccga gccccggggc cgagccggtg tccatcacga cctcgatccc
    16981 cgcggctgcg gtcagggccg cgcagatccc ggcgcgcagg agcggattgc gttcgacgac
    17041 ggcgacgtgg agcgggctgt gcgaaacgga tgcatacgtg gtcaaggctg cgactccgat
    17101 gagattccga caggttgccg cagcatggga agtacccgct agcggatcac tagggagccg
    17161 ccccttaccc tccacacatg cgaagtgatc ggggcgcgat gttcgagtac cggatcctgg
    17221 ggccgctcga cgtgcggcgc gcgggccgag ccgtgcccgt caccgccccc aaggagcgcg
    17281 acctgatcac gctgctcctg ctgagggccg accggaccgt ccccgccgag gacctcatcg
    17341 acggactctg gggcaccacg ccgcccgcga ccgcccgtac caccctgcag aactacatca
    17401 agcggctgcg ccggatcctc cagcagcccg gcaccggaca ccccgagacg ctcgtcaccc
    17461 ggccgggagg ctacctgctg cgcctggagg acgccttcct cgacctcagg gagttcgacg
    17521 ggctggtccg ggccgccgcc gaggccaccg cccgcgggga cgacacgacc gccgccgccc
    17581 gcctcgacgc cgcgctctcc cactggcgcg gcgaggcgct gtccggcagc cgctcgcagc
    17641 acctgcggca actggaggcg ccccgcctcg aagagtcccg taccgtcgcc ttcgaacagc
    17701 gggtagaggc cggcctgagg ctgggaatgc acgcggagct catcgccgga ctgcgcgtcg
    17761 aggcggcacg gcatccgctg cgggaacgcc tccaggcaca actggtgctc gccctctacc
    17821 gttcgggccg ccgcggcgac gcgctcgccg ccgcccgcca ggcccgcgac cacctcgtac
    17881 gggaactggg cctggagccc ggcccccacc tcgcgcggct gcacgaccgg atcctggccg
    17941 acgacccggc cctgatggac ccgcgcccga aggccccggc ggtcgacgcc gcgccgggcg
    18001 cgcccacccc gaccgccccc tcgactcctc cgggacggcc cggaccggcc gggcccgacc
    18061 ccgcggccgc ggcctcgctc tccgtgctgc ccgcccaact cccgccctcc accatggtgt
    18121 tcaccggccg cgccgaagcg ctccggcgac tcgacgaact gctgcccacc gccggacccc
    18181 agccctccgg cgcggcccgc atcgcccaga tcagcggcca gggcggagtc ggcaagacgg
    18241 ccctggccgt gcactgggga cacggccggc gcaaccggtt ccccgacggc cagctctacg
    18301 tcaacctgcg cggacacggc ggtcagcggc cactgcggcc ggtcgacgcc ctcggcggct
    18361 tccttgaggc gctgggcgta ccggcccggg aagtcccggt gtcggaggac cgctgcgcgg
    18421 cccggttccg ctcgctgtgc gccggccggc ggctgctggt gatcctggac gacgccagct
    18481 cggaggaaca ggtccgaccc ctgctgcccg gcagcgccga ctgcatggtg atcgtgacca
    18541 gccgccggac cctggccggg ctggtggccc gcgacggcgc cctgcccgta cccctgccgg
    18601 tcctggaacc gtccgaagcg gaacggctgc tggtcaacat cctcggagcc ggccgcgtct
    18661 cgcgcgaacc cggggcggcc gccgcgctga ccgccgcctg cgcccgtctg cccctcgccg
    18721 tcggcatcag cgcggccgac ctcgccctcc accctgagcg gaccctggcc gagcaggtcg
    18781 agcggctcgt cgccgaggac cgcctctccg cgctggagct ccccggggac agccacagcg
    18841 cgctgcgcac cgtcttcgcg atgtcctacg ccaccctcga cccggacgcg gccaggatgt
    18901 tcggcctcct cggcaccatg ccgggcgcgg acatcaccgt ccgcgccgcg gccgcgctgg
    18961 ccggagtgac gcgcgagcgc tcccaggccc tcctggacga cctgacccgc tcccacctcc
    19021 tcgacgaggg agccgtcgga cggtacgcct tccacgacct cctgcgcgcc tacgcccgcg
    19081 aacgcgtcct cgacgaacag cccgaggacg tgcgcagcgc cgccacggac cgcctctacg
    19141 cctggtacct ggccaatgtc gacaaggcgg cgaaggtgat ccagccgcag atgctgcggc
    19201 tggggaccta cacggacggc gccgacctgt ccttcgccac cccggaggac gcggtcgggt
    19261 ggctcgattc cgaacgggcc aacgtggtgg ccatggtcca gcgggccgcc gagcatggcc
    19321 cccgggcggc ggcctggggc ctggccgacg ccttccggcc gtacctgatg cactcctcgt
    19381 acaccgccga gtggctggcg gtgggcgagg ccgggctggc ggccgccgaa gccgacggga
    19441 acgccgtcgg ccaggcggcc ggccaccgca tcctgtcgag tgcctacctc gtcctgggcc
    19501 ggtacgacga ctgtgtccgc cacgacctcg cggccgtgga gctgtaccac ggccaggggc
    19561 acaccagcgg ggaagcggcg gcgtacaaca gcctctcgct ggccgcgtgg tacggaggcc
    19621 ggctcgacga cgcggtggag tacggcaacc gcggactcgc catcgcgagg accctggagg
    19681 acaaggtccc cgaactcatc atcagcacca acgtgtgcgg catcctccac gaggccggca
    19741 tgctgcggga ggccgaggag cacttcgagg gcatgatcgg cggccaggcc gtggaccaga
    19801 cgtcgacgac ggaaagccac accttcacca acttcgccgc cctcctgcac gaccggggcc
    19861 tgccggagcg ggccgcggaa ctcctcgcga aggccgaggc gatcaggcgc cgggccggac
    19921 aggcgcccag cagcctgagc tacaccctgt actggaaggc ggtcatggcg ctccaggccg
    19981 gagaccgggc cagcgccctg gagcacgtgg aggaaggatt ctccagcgcg ggcggcgaca
    20041 tcagggccca ggcgtacctg tacgtcgccc gagggatgct cgccgagcgc accggggggc
    20101 acgagacggc cctgcgcagc ttccagcagg ccagggacct ggccgaacag tgcgcctcgc
    20161 gcaaaccgga actcgaagcc ctgacgggga tggcgcgctg caacctgcgg gcgggccgcg
    20221 tcgacaccgc gcgctccttc gccgaagagc tgctgaagga cgccaccgcc agcggctacc
    20281 ggctcttcca cggctacgcg ctgacgctcc tggccgagat cgcgtgcgag gagggcgacc
    20341 cggccgaggc gcaacgccgg gccggggaag cggccgccgt ccaggaggcg aacggccacc
    20401 ccaggggcca ggccgaggcg ctcatcgccc tggcccgagc gctccgcgcg gccggcgaca
    20461 ccgagggcgc acgggcccgc gtccaccagg cggcgcacct gtggtccggc ttcgccccgc
    20521 gccgcgccgc aagcatcctg agcctggccg actgaccagt gctggggcct taccggtcac
    20581 agcactaggc ggcttgcccc aggtccaggt acgtcgcccg ctgcaccacg cgcagccggt
    20641 cgaggacttc ggcgacctcc gcccggtccc tgcggccggc ggcgaacgcc ttcaggacct
    20701 caaggacccg cgcggacttc cagcaccgca gcgcggcctc gtccaccagc ttcggacccg
    20761 ccacccgcat caggaccgcc agccgccggc gagcgcgccg cgccctgcgc cggccccacc
    20821 agccctccgg cgcccggtcg agggtgcgca gagcgtccat ccccttcacc agggcccgga
    20881 tccgggcctc ttgcggggcc gtccagtccc gcccccggcg gccgggaagc gcggacagga
    20941 cctcctcgac ggccacccgg gccgcggccg gcccccgttc gtccagcagg gtgacggccg
    21001 accacagcga ggtttccacc gcgggcgcgt tgtctcgttc ggacacgact taccccctct
    21061 ccgttcctga ctcatgcccg cacgaccgcc acgcgcaacg cgaagggggt gcagcggccc
    21121 tttcaggaac gcacggaccg gcgagatccg gcctccgggc atgggccgcc cgggtgaggg
    21181 ccgctccgct cacccccgcg gctcaccccc gcgtctcacc cgcgccgctc acccccgtcg
    21241 cccagttccc gctcggcggc atccagcagc atctccagcg cgaccggata ggcactgtgc
    21301 ggcatgcgcg cggccagcag cccggccgtc gccgcgatgt tcgggtactc ccgcgccggc
    21361 agccgggcgt acgtcgactc ccaccgctcc tcgtccgagt cgcgcgcctt ctccgacagc
    21421 gccagcgccc ccgcgtcgag cgccgcgaag gccaggcact ggtcgatgta cgcgtggtag
    21481 atccgtacgg cgtccacgtc cccgaacccc gccccccgca ggctggcgag gatcgcctcg
    21541 tcggcggcga tctcgcgcgg cctgccggtc acccggctcg cggtcagcag cgcggcctgc
    21601 gggtgcgcga ggtacgcccc gtggatgcgc agcccgagtg agcgcaggtc ctcgcgccac
    21661 cgcccggtcg gggcccagcc ggcgagcgcc cggccgatca gctcctcgcc gatggccagg
    21721 gtcaggccgt ccatgccgtc gaagtaccgg tacagggtgc tcggatccgc ccccagggcg
    21781 gcgcccaggc gccgggcgga caggcccgcg ctgccgtgct cgcgcaccat ccgcagggcc
    21841 gtctcgacga tcagccgctc ggagagcacc gtcccctgcc gcgtcggccg ccgccgtctg
    21901 cggcgctcct ccggaaccac gtccttcgcc atccacccgc tcccgtcctt atgccaacac
    21961 cattgacctt aatccggagc acccggttcc atcagtcccc tgaggcacac gcctcacaga
    22021 gaaaggacct cgccatgcgt gttctgctcg tgggtgccgg cggcgtgggt agcgcgatca
    22081 ccaagatcgc cgcccgccgc gacttcttcg accacttcgt cgtcgccgac tacgacctga
    22141 cccgcgccga ggccgccgtc gccgccctcg gcgcggagga gcgccggttc agcgcctgcc
    22201 gcgtcgacgc ctccgacgag agcgccgtca cccggctgct cagcgagcgc ggctgcgacg
    22261 tcctgatgaa cgccaccgac ccgcggttcg tgatgcccct gttcaacgcc gcgctggcgg
    22321 cgggcagcca ctacctcgac atggcgatgt ccctctcccg cccgcacccc gaccacccgc
    22381 accgcgcatg cggcgtgaag ctcggcgacg agcagttcga acgggccgcg gagtgggaga
    22441 agtcgggccg cctcgccctc gtcggcatgg gagtcgagcc cggcctctcg gacgtcttcg
    22501 cccgctacgc cgccgaccac ctcttcgacg agatcgagga gatcggcatc cgcgacggcg
    22561 ccaacctgac cgtcgagggc cacgacttcg ccccgtcctt caacatctgg accacgatcg
    22621 aggagtgcct gaaccctccc gtggtctacg agcgcgagcg cggctggttc accaccgaac
    22681 cgttcagcga gccggaggtc ttcgacttcc ccgagggcat cggccccgtc gagtgcgtca
    22741 acgtggaaca cgaggaggtc ctcctcgtcc cgcgctgggt cggggcccgc cgggtcacct
    22801 tcaagtacgg cctcggcgac gacttcatcg gcaagctcaa gacgctccac gccctcggcc
    22861 tcgactccac cgaccgcgtc gccgtccgag gcgaggacgg ccgcgaggtc cgcgtctcgc
    22921 cccgcgacgt ggtcgccgcc tgcctgcccg acccggcgac gctcggggac cgcatgaccg
    22981 gcaagacctg cgccggcacc tgggtcaagg gcaccaagga cggcctgccc cgcgaggtct
    23041 acctctacca cgtggtcgac aaccagtggt ccatgcgcga gtacggctcc caggccgtcg
    23101 tctggcagac ggccgtcaac ccggtggtcg ccctcgaact cctcgccacg ggcgtctggt
    23161 cccagcccgg cgtcctgggc cccgaagccc tcccgcccac ccccttcctc gacctcctca
    23221 ccgcctacgg ctccccctgg gcgatccgcg aacaccccac cacccagccc ccgcgccact
    23281 gaccaccggg cgaccatcag ccccgtgcgc cacccggcgt caggcccgac ccggcgccgg
    23341 accttcgcaa cctcccccgt gtgtgcggcg ttgtgctcct gttggccccg atcttcagga
    23401 gtaccgcgtg acgcctacct ctccacccgc caccgacggc ctgttgcgcc agaccctcgg
    23461 tgaatggcgc atcgggctgg tggcctggcg gctgctcgtc ctgcagaccg cgcacccggc
    23521 cgtcgcggcc ggcaccgccc gctactccac ctaccgggcc cacccctggc ggcggatcga
    23581 gcacaccatg gacagcggca gccggctgtt cttcgccggg cccgaggagc ggcggcgcga
    23641 gatcgcccgg ctggagcgcg cgcaccgccg gatccgcggc accgacgacg ccggccgccc
    23701 ctacaccgcc gaggacccgg aggtccgcgc ctgggtgatg ctgacgctgt acgaggccat
    23761 gacggccatg cgcgagctct ccggcgatcc gctcgaaccg gccgggctcg acgcgctgta
    23821 cgcggagttc aaggaggtct gcgcggccct cggcatcccc gacgaggtcc tcccggcgac
    23881 cgccgccgac gtacccgcgt acgtcgaccg gaccgtccgc gaggtcctcg aattcggcga
    23941 ccaggtccgc tacctgctct tcgagatgct gcgcgaggca cccgcccccc gccggctcgg
    24001 ccgcctccgg cctgcctggc cgctgctgcg cgccgtcgcc gcgagcgtgc tgaccagcct
    24061 gaccgtcgcc gacctgccga gggcctggca cgagcggttc gccatgcccc gcacccgtac
    24121 cgccgccgcc ctgtcctgga cgctgcaccg cggcatgcgt caggtgatga cccgtctgcc
    24181 ggaccgcctg cgctaccgcc actcgtccgg tgaggaaggc cggcagcgat ctgctgcccg
    24241 gcggcccacg gcgcccgcgc cgctgccccg gccccgcacc gtcgactccc gccccgcacg
    24301 cctggaggcg ttcttccggc aggtgctcga ccagaccggt gacgggcggg tggactccgc
    24361 cgacctccag gcgatggtcc acaacgtgtg ctggcagctg gaactccccg tcgagcgcga
    24421 ggaccggctc tacgccgcct tcgagtcctg gtgggagcaa ctgcgcgagg ccatggacgc
    24481 ggacggcgac ggcgcggtgg agtgcgccga gttcgtgtcc gcgatgctgg ggggcatcga
    24541 ccgggatccg cactacctcg accggggcct ggggccggcg gtgcgcgcc
//
