LOCUS       NZ_CP011664            21125 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 chromosome 1, complete sequence.
ACCESSION   NZ_CP011664
VERSION     NZ_CP011664.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7320152
            Orig. end                         :: 7341277
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011664.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21125
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="27"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21125
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21125
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11125](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11125
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(460..474)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     gene            complement(573..1250)
                     /locus_tag="M444_RS31675"
                     /old_locus_tag="M444_31660"
     CDS             complement(573..1250)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020387.4"
                     /locus_tag="M444_RS31675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31660"
                     /product="RES family NAD+ phosphorylase"
                     /protein_id="WP_008744158.1"
                     /transl_table=11
                     /translation="MARPAKLPGKLAGTPHQVVWPAGTTLYRVHRKSRSAADFNATVVD
                     HHFGGTRFDSTPNDEYSYLYLAPSAETALVESLLKELPVDDGEPRVVSYSAIEDRRLSR
                     LELLTDVTLLSLLDRRATSAVNQGTWLIQSESPDYPFTRRWGHWLRGQADWAQGLIWTS
                     RQNHPEPTAVLFGDRFGPLVREDGNEVLRPVPGGIDLDDSAGRRWLDSALDPYCARVGA
                     PAD"
     gene            complement(1252..1860)
                     /locus_tag="M444_RS31680"
                     /old_locus_tag="M444_31665"
     CDS             complement(1252..1860)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS31680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_31665"
                     /product="hypothetical protein"
                     /protein_id="WP_050779437.1"
                     /transl_table=11
                     /translation="MLGLFANVSDDDGLRAVGEAVAAHVRARLPADDPALRRWRSTMAP
                     DRSAAPGLIRRMATRHGHHVPVRSSGARPSHHRAEPAGPPAPSSWDRIRERLLSASSLS
                     EAQVRDVLRQDPRHPHLIRLTRKGGEVRLPSFQFQEDCVPVPLVLAINEVLRASKDPWG
                     AADWWLGPNHWLAAPPAEVLGSVPDDELMAAARAVGEGD"
     misc_feature    1887..1900
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.8"
                     /tool="antismash"
     misc_feature    complement(1894..1910)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.74"
                     /tool="antismash"
     misc_feature    1945..1959
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     misc_feature    2058..2070
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     gene            2301..7661
                     /locus_tag="M444_RS31685"
                     /old_locus_tag="M444_31670"
     CDS             2301..7661
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024180.4"
                     /locus_tag="M444_RS31685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31670"
                     /product="CHAT domain-containing protein"
                     /protein_id="WP_148639894.1"
                     /transl_table=11
                     /translation="MDASESDDIRALEREIAALRERARVLHPGGQERWNTEADLAELLF
                     VHALEVASAEAATAAGAPPLPEGLAEARALLDRLLSQRRPGSASYHWACLLAARAARGE
                     AELTGDPDARDAAIERFETAIAPLPPYGPDTFPPLPGEPEWWTPALAVDARCELGLALY
                     NRSRELTGGSRSRDLDRIVTLLTPVVDGPEAGLAQDLQVTLACLGLALADRSRAPGHRG
                     PDRPADRTEAIGRLRAAREAPSEDEVPGAVPFQLALLLFCEHDDGCGGSEGADGRGPSA
                     RPTGELDEALALLWPLTLDPSADGGEATELATMTARHLYEHDGGPAAETALIEWHRRAI
                     DHPGTQRRQVRANRTDLALLLIDRAERGATAPAPGTPAPGTPSRSDDLGEAARHLELAL
                     DDLALKERAPSVRLRAEDDPPETDADRAEERLNMLLGLVTLLSMLLPESSDDARLDRLI
                     RRGQELIEVIPDADTERGGACLRLALALFERTSRRTLPQLPALLMRAMTPDRADPGISL
                     VANVPGVREDNELAIALLRTGVGLYGYEDELYEAAAIALAVSLLIGYTVRLPERDTALI
                     RDAVRWFRIVLDRVPEGGELHSPDLEDLFIGALLNSVWTSEPFVRAQTGSWRDGEGIPD
                     VSRNQSVEDDLQSLRHLLETAVRRREQPVPVYEMVLLLITFMRGKGELDDAEARHWRDR
                     LRRASAYTDPAEESLKGFLLLAAGAFGYELARRGAAGPAELAEADRLLREGARHMPPGS
                     DFAEWAEGLRATGPATLIQQLLGVFMGGASASGAAAAGAPGAARRPADDAVRAPGPARP
                     PGSARPPGPVRPPARSAPAEAEDIPLSAAAVLPGDGSPCPFTEPVGRVLEIVAGPAGPA
                     EQRSAPVMAAHALALHRRWLHESEIADLTDAVTLTRRAIAAAEGADGPLADRLSLLLAG
                     MLRDRYLLIGDRMDLHAARTAYERLRDRSDPRAPHPELATLLARPGAEGQPDLAALLRP
                     ARPAAPGAFSAELLAAAALTGLLAARADGAADRAAAELAEAAEALPSDHPLLPAVLSES
                     GLFRATRAARADELAALREAVEDVVRAAALCPPGSAHRAPLLLRAAAVLCAHSDALDAA
                     DPAGRAAPGSRTSSLDRGIGLLSGAVDEAGPSFHGARARCRYGLGSLLLTRFRRSRDRA
                     DLDRAVGLLRDARTAVLSRPGDPFTVLLTRALAEALRAHGPEDPDHRAQSREAAKSVLA
                     AHGRAVLLQTGTETALDSARAAGSDMMRLVEWCLTDGRTEEALEALELGRGLVLNAATV
                     AASVPELLEREGRPELAQAWRRADPGRVPGTPADGPVVIPDGLRLLVLQALEGGPAERR
                     ILSAPTPAEIGRALRTVGHDALVHLVPGRDGSGDALIVTATGAVERLRLPGLCVTDDGP
                     AAAYGEALQEFAAATREPVVLPGEDDPAVMWELYRRGRKRLGRASDRWRGALEPLCSWA
                     GEVAMAAVIEHVGAGRRHRPARLVLSPVGMLGMVPWHAARLPGAPGVSGEPGGGYACGR
                     AVISYCSTSRQLVEVAARARLPWNGAQAVVADPGGTPAMHEEARLIAALYPGATVVGPV
                     DDVPEPGGPGSRPPSRPATAAAVAPLLPGRGGSSVAVCHVNCHATARATPSASSLDLHP
                     AAPVPQVLTLAEIQALAHGRDPSAPGGLLVLANCTSDLTLADYDEALTLSTAFLTAGAA
                     SVVGSLWAIADDIRTSMVMYVFHHYLTGRGLPGHPEAVGSPADALRAAQLWMLDPHRIV
                     PPALSAVLEERPGLDLDAPHIWAAFTHHGH"
     misc_feature    7678..7687
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.37"
                     /tool="antismash"
     misc_feature    7684..7698
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.36"
                     /tool="antismash"
     misc_feature    7688..7702
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     gene            7798..8283
                     /locus_tag="M444_RS31690"
                     /old_locus_tag="M444_31675"
     CDS             7798..8283
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS31690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_31675"
                     /product="hypothetical protein"
                     /protein_id="WP_053065838.1"
                     /transl_table=11
                     /translation="MVAALKFAHSNLDGLKVKELVDKKGIEWYINHCAALAATTGVASG
                     MGGPATMVLGVPADMANTIAQQFRVTMAVIYHKTGSYSLSFDEFMKIVAVSLGVEVGTQ
                     VVVRVAAEIFKRLTAKIAGKFIPLLGGVIGGGLNYGFIKAQGKAMLALDFDKLSRSA"
     misc_feature    8266..8268
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8266..9414)
                     /locus_tag="M444_RS31695"
                     /old_locus_tag="M444_31680"
     CDS             complement(8266..9414)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016827487.1"
                     /locus_tag="M444_RS31695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31680"
                     /product="DUF6596 domain-containing protein"
                     /protein_id="WP_037798880.1"
                     /transl_table=11
                     /translation="MNEALLRSLTPSVLGILVRRGADFAAAEDALQEALVEAVRVWPAD
                     MPREPKGWLVTVAWRRYLDAARSDTARRRREDLVEEEPAPGPAPGVDDTLQLYFLCAHP
                     ALTPSSAVALTLRAVGGLTTRQIAQAYLVPEATMAQRISRAKRTVSGVRFDQPGDVATV
                     LRVLYLVFNEGYSGDVDLAAEAIRLTRQLAASIDHPEVAGLLALMLLHHARRSARTGPD
                     GSLVPLAEQDRGRWDTVMIAEGVAILQAALARDRLGEFQAQAAIAALHADAPTAGESDW
                     VQIVEWYDELVRLTDSPVVRLNRAVAVGEADGPRAGLAALAALDDALPRHTAVAAYLHE
                     RDGDLETAARLYAEAARKASNLAERDHLTRRAARLTQLRRTG"
     gene            complement(9423..9830)
                     /locus_tag="M444_RS31700"
                     /old_locus_tag="M444_31685"
     CDS             complement(9423..9830)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007512669.1"
                     /locus_tag="M444_RS31700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31685"
                     /product="YciI family protein"
                     /protein_id="WP_037798881.1"
                     /transl_table=11
                     /translation="MAKYLLLKHYRGAPAAVNDVPMDQWTPEEISAHMRYMQDFADRLE
                     GTGEFVDGQALAPTGTFVRYDGEGRPPVTDGPFAETKDLIAGWMVIDVDSYERAVELAG
                     ELSAAPGAGGKPIHEWLELRPFLTAPPTITE"
     misc_feature    9805..9821
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.71"
                     /tool="antismash"
     misc_feature    complement(9905..9925)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 18.75"
                     /tool="antismash"
     misc_feature    complement(9988..10003)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.28"
                     /tool="antismash"
     gene            10001..11125
                     /locus_tag="M444_RS31705"
                     /old_locus_tag="M444_31690"
     CDS             10001..11125
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003959586.1"
                     /locus_tag="M444_RS31705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31690"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_037798883.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.2e-30, bitscore:
                     104.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHATVNAATLERVLGHRTRFDARFGQYFDSLAGRFDLPVPSRYVP
                     RCLDLLRDLSMRGGKRLRVVLLYEAARLVTTEEVPGLAEAALSIELLQTHGLVHDDIID
                     DAPLRRGGPSTYYAYRREFPGHGATALGLALLAGDLAGFLSTQVLLEAEAPVALRQALL
                     GVQTRTAAETVAGQIADLERDAHALPDEEFLHTVTDFKSARYSILAPLTMGLLAAGEDP
                     APHRARLHRYARLVGISEQMRDDCLDLFGPFGEGAGSDAVAGAAPAVADKSTGADIRSG
                     RRTYAVRAVLAAATGADAALVEAALGDPRCPDATLERIREIARAAGVDGRLKAEIRRHA
                     EEAAAEAASWEPYWRAEAVELFRGLPMWNVDRMP"
     gene            complement(11132..11857)
                     /locus_tag="M444_RS31710"
                     /old_locus_tag="M444_31695"
     CDS             complement(11132..11857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020550765.1"
                     /locus_tag="M444_RS31710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31695"
                     /product="DUF4386 domain-containing protein"
                     /protein_id="WP_037798884.1"
                     /transl_table=11
                     /translation="MGETRRLAVVAGALFLVTEVAAIGGLALYRPVLDGPGYVVGSGAE
                     TRVFLGALCELVLALAVMGTGAALYPVLRRRGEAAAVGYVCGRLLEAAVIVVGIVSVLA
                     VVTLRRSAGPSGAADAASLVTAGKALVALHDWTFLLGPNFVLGANTLVLACLLYTSRLV
                     PRAVAVLGLAGGALICASATAVLFGVYEQVSVAGSLAALPVFAWEVTLAVRLLFKGFDE
                     AAGDGAGEGARARVDALAG"
     misc_feature    11941..11959
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.83"
                     /tool="antismash"
     gene            12002..12748
                     /locus_tag="M444_RS31715"
                     /old_locus_tag="M444_31700"
     CDS             12002..12748
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010476397.1"
                     /locus_tag="M444_RS31715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31700"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_037798886.1"
                     /transl_table=11
                     /translation="MPADVPAEESRRTPLSRDRVLRAAVAFADGAGIEALSMRRLAQEL
                     GVVPMALYKHVANKEELLDGMVEAVVAGLDPHVPGADWKSAVRRRILGAREALVRHAWA
                     AQVIRSRTSPTPAVLAYLDSVIGMFRAGGFSLDLTHHAMHALGSRVLGLTEELFDAPPS
                     PGPRATATASVSASAADPAQTAAREAMALRYPHVTELAGAVAHDRSSVVGGRGCDDRFE
                     FEFALDLLLDGFERLHGQGWTSAPRP"
     gene            12781..13401
                     /locus_tag="M444_RS31720"
                     /old_locus_tag="M444_31705"
     CDS             12781..13401
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268533.1"
                     /locus_tag="M444_RS31720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31705"
                     /product="nucleoside/nucleotide kinase family protein"
                     /protein_id="WP_047960820.1"
                     /transl_table=11
                     /translation="MEFAELEERARTLAASGGRRILGIAGPPGAGKSTLAARLARALGA
                     ELAVAVPMDGFHLAQAELVRLGRADRKGAPDTFDAAGYAALLRRLRAAPGEGAGAVYAP
                     AFDRALEEPVAGSIRVGPAVRLVITEGNYLLYGAGEWAQVRPLLDEAWFLAPDDAVRVR
                     RLVDRHVRHGRDRAAAEEWVSRSDESNARLVAPGRAGADLVLE"
     gene            13421..14695
                     /locus_tag="M444_RS38745"
     CDS             13421..14695
                     /EC_number="2.7.11.1"
                     /GO_function="GO:0004674 - protein serine/threonine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012298.4"
                     /locus_tag="M444_RS38745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine/threonine-protein kinase"
                     /protein_id="WP_053065839.1"
                     /sec_met_domain="Pkinase (E-value: 2.5e-45, bitscore:
                     153.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAESGALIGGRYRLVELRGRGGMGRVWRGLDERLDREVAVKEIV
                     FPDGVDEERREALLHRFVREARAAARLNDPGIITVHDVVEHEGAPVIVMEYVTGPSLAA
                     QVARGGGMPVRRVAELGVLMVKALRRAHAAGIVHRDLKPDNVLLMDDRVIITDFGIAHV
                     ADATMTLTRTGTLLGTPAYMAPEQLEGGPPTPATDLWSLGATLYCALEGRPPFVAETFS
                     ALCVAIVMQDPPVPGRAGPLAPVLAALLTKDPAGRATAEQALAALEAVAGGAAQREPQP
                     QPQPPPQPQPEQRRRQRLPGSSLRGAGCFALVWLGTLLPWNHIREWHGFQRELLVGATA
                     AVVALANAGLRPRGPAGPGWALFAGLNLALFLVAALIWPVWGLPAVIANGLLVGTVSWS
                     LWWSLSRAGVPAGVRPDGVSERGTR"
     gene            complement(14673..15533)
                     /locus_tag="M444_RS31730"
                     /old_locus_tag="M444_31715"
     CDS             complement(14673..15533)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-272). E-value: 3e-26.
                     Score: 84.5. Matches aSDomain:
                     nrpspksdomains_M444_RS31730_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018558022.1"
                     /locus_tag="M444_RS31730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31715"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_037798890.1"
                     /sec_met_domain="PF00561 (E-value: 1.6e-21, bitscore: 75.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-18, bitscore:
                     66.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLHFFTSYDGTELAYRVTGDGGAPPLVCLPGGPGRAAAYLGDLG
                     GLGAHRTLILPDTRGSGASAMPADLATCRVDRLVADVEALRGHLGLETFDLLGHSAGGS
                     LAQLYAAAHPGRLRRLVLVTPSFASIGLPSDTGAEEVLRSRAAEPWYARALPAYRAVKA
                     ARSFEEAAAHRPAHEPLMYGRWDAAARAHAAADPAQRSLPVSEAFYAGYAPDTEALAAR
                     LARLAAPVLLLAGERDLWPTAAAAARAAGVFPEAELTVLPGAGHYPWLDDAAAFAAAVT
                     GFLAR"
     aSDomain        complement(14718..15461)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M444_RS31730_Abhydrolase_1.1"
                     /evalue="3.00E-26"
                     /label="M444_RS31730_Abhydrolase_1.1"
                     /locus_tag="M444_RS31730"
                     /protein_end="272"
                     /protein_start="24"
                     /score="84.5"
                     /tool="antismash"
                     /translation="PPLVCLPGGPGRAAAYLGDLGGLGAHRTLILPDTRGSGASAMPAD
                     LATCRVDRLVADVEALRGHLGLETFDLLGHSAGGSLAQLYAAAHPGRLRRLVLVTPSFA
                     SIGLPSDTGAEEVLRSRAAEPWYARALPAYRAVKAARSFEEAAAHRPAHEPLMYGRWDA
                     AARAHAAADPAQRSLPVSEAFYAGYAPDTEALAARLARLAAPVLLLAGERDLWPTAAAA
                     ARAAGVFPEAELTVLPGAGHYPWLDD"
     CDS_motif       complement(15204..15251)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M444_RS31730_0001"
                     /evalue="1.80E-04"
                     /label="NRPS-te1"
                     /locus_tag="M444_RS31730"
                     /protein_end="110"
                     /protein_start="94"
                     /score="14.1"
                     /tool="antismash"
                     /translation="DLLGHSAGGSLAQLYA"
     gene            15629..16591
                     /locus_tag="M444_RS31735"
                     /old_locus_tag="M444_31720"
     CDS             15629..16591
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024248.4"
                     /locus_tag="M444_RS31735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31720"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_047961198.1"
                     /transl_table=11
                     /translation="MSVEIRLTAAEVARVRFAVSPLAETVLGVRAALTATGQAVHHRWL
                     AEARDVLRDDPELPLLRNLLGHCLPSFLLPVPRERLPSLDEELADLCATDPAYFAAECA
                     AGAGARAAGRLPAAEVALPRLAGALRRCHDRLVAPHWGRMRAVLDADVGRRAVALVDGG
                     VEGLFTQLHRDIAWREGELVVGGRRRAGAAPCAVEASGHGLVLLPSVFAWPDVLVDRSP
                     VTAASIRYPALGVGLLWEPDRPTRDGLAAVLGATRAALLAALAEPLTTPALAARLGVTP
                     SAVSQHLGALRGAGLVSTRRSGRTALHLRTARAVDLLTG"
     gene            16737..17417
                     /locus_tag="M444_RS31740"
                     /old_locus_tag="M444_31725"
     CDS             16737..17417
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982876.1"
                     /locus_tag="M444_RS31740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31725"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_047960821.1"
                     /transl_table=11
                     /translation="MARPAPTPARSRRRRRIAVAGAALCAGLFVLLAVLVTARHGAPYP
                     LDSAAHRWSVRHRPAVAVAFARAVTSTGSGPFPYACAAAAGAIAGRGTRERLWGAAAAL
                     LFLGFAQAVRFGVLHLIGRPRPPLAEWATVAHDHSFPSGHTTASALAAGLLAWALLRRA
                     GPAAAAIPCVILAGWAVAVGLTRIYLGVHWPTDVLAGWLYALTWFAVGYAVFPYVLRMF
                     TDTD"
     gene            17444..18232
                     /locus_tag="M444_RS31745"
                     /old_locus_tag="M444_31730"
     CDS             17444..18232
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657070.1"
                     /locus_tag="M444_RS31745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31730"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_037798892.1"
                     /transl_table=11
                     /translation="MWAAGEAYEPYVGRWSRLVAAEFVRRLAAAPGGSWRDIGCGTGAV
                     ARAVLAAAAPRRVIGVDPAESYVRHARRHLAGPRADFVVGDALALPFPDGRATAAVSGL
                     VLNFVPDPARAAAEMVRVVGPGGTVAVYLWDYGEGGMRAIRAFWDAARALDRRAEALDE
                     AVRFPLAGRKPLRELLTGAGLAGVETGEITVPTRFRDFDDYWGPFLGGQGPAPAYVASL
                     PEDHRAELRERLRATLPRACDGSIRLTARAWTAWGARPPG"
     gene            complement(18330..18545)
                     /locus_tag="M444_RS31750"
                     /old_locus_tag="M444_31735"
     CDS             complement(18330..18545)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS31750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_31735"
                     /product="hypothetical protein"
                     /protein_id="WP_037798893.1"
                     /transl_table=11
                     /translation="MYEMRAESIADRCQLLWHVIAKDTTFSTLCGSLLNPDQTPPPEAD
                     PAAERYCAPCMTAFSRAVHAFGTPSE"
     gene            18696..18989
                     /locus_tag="M444_RS31755"
                     /old_locus_tag="M444_31740"
     CDS             18696..18989
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158031.1"
                     /locus_tag="M444_RS31755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31740"
                     /product="hypothetical protein"
                     /protein_id="WP_037798895.1"
                     /transl_table=11
                     /translation="MAWASWTTTGVFPGAGGVRTEEVGIISGDLTVHTTWTGAQAQVAV
                     QYSSSSDWFTLSGSPVECVSEPESRDLHQAVVEAVRGGGGSGVPPHWATFAA"
     gene            complement(19266..20063)
                     /locus_tag="M444_RS31765"
                     /old_locus_tag="M444_31750"
     CDS             complement(19266..20063)
                     /EC_number="1.1.1.30"
                     /GO_function="GO:0003858 - 3-hydroxybutyrate dehydrogenase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (24-177). E-value: 6.3e-07.
                     Score: 21.4. Matches aSDomain:
                     nrpspksdomains_M444_RS31765_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979647.1"
                     /locus_tag="M444_RS31765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31750"
                     /product="3-hydroxybutyrate dehydrogenase"
                     /protein_id="WP_047960823.1"
                     /transl_table=11
                     /translation="MTSKLPPALPLPAPGPAGVDLRGRVALVTGGGSGIGRACAVALAA
                     AGAAVHVVDVDAPSAASVARLVRGRAHVTDLADPAAIEELPAHVDILVNSAGLQHVAPI
                     TQFPVERFALIQRVMVTAPFLLLRRVLPHMYASGWGRVVNISSVHGLRASAYKSAYVAA
                     KHGLEGLSKVTALEGAPYGVTSNCVSPGYVRTPLVEGQIADQAAAHGIGAADVVADVLL
                     TRSAIKRLIEPEEVAAAALWLCGPHTGYITGISLPLDGGWAAN"
     aSDomain        complement(19533..19991)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M444_RS31765_PKS_KR.1"
                     /evalue="6.30E-07"
                     /label="M444_RS31765_PKS_KR.1"
                     /locus_tag="M444_RS31765"
                     /protein_end="177"
                     /protein_start="24"
                     /score="21.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGGSGIGRACAVALAAAGAAVHVVDVDAPSAASVARLVRG
                     RAHVTDLADPAAIEELPAHVDILVNSAGLQHVAPITQFPVERFALIQRVMVTAPFLLLR
                     RVLPHMYASGWGRVVNISSVHGLRASAYKSAYVAAKHGLEGLSKVTALE"
     CDS_motif       complement(19845..19985)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_M444_RS31765_0001"
                     /evalue="2.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="M444_RS31765"
                     /protein_end="73"
                     /protein_start="26"
                     /score="13.7"
                     /tool="antismash"
                     /translation="LVTGGGSGIGRACAVALAAAGAAVHVVDVDAPSAASVARLVRGRA
                     HV"
     gene            20258..20755
                     /locus_tag="M444_RS31770"
                     /old_locus_tag="M444_31755"
     CDS             20258..20755
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS31770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_31755"
                     /product="hypothetical protein"
                     /protein_id="WP_037798899.1"
                     /transl_table=11
                     /translation="MTPDIDTAELVAAVNTVERARHLLGEARDELGGAGVSRDQEWTAA
                     GSPVQTLQGADDMHRGSGQFLDDLALALGYAAAGLAEQALRQRERAGQGFLGLSGADRM
                     ARPLPAPTVEALELLRGLDLLTPEFRERITGALEAEAATYPDPAPQRPLRLGTSGLTPT
                     AG"
     gene            complement(20765..21013)
                     /locus_tag="M444_RS31775"
                     /old_locus_tag="M444_31760"
     CDS             complement(20765..21013)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100553.1"
                     /locus_tag="M444_RS31775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_31760"
                     /product="DUF6296 family protein"
                     /protein_id="WP_037798900.1"
                     /transl_table=11
                     /translation="MSEDHEDRYELVFGSGEPESEGEDLVVVSRTAQKGPGGHPVYADS
                     TGIVRAEISDQGEVRMLPSGGQQSLAQPTRARRPGSP"
ORIGIN
        1 tcacggccga ccctgaaccc ctcggcgaag tcggtgccgc cctgcgggct gagcgtgggc
       61 atccgcgcgt gggccatgtc gctgagcggc aggacgcagg cggccgtgtc ggagaacgtg
      121 accaccgaga cgcgggcgat ctctccggtg gtcgggtcgt ccaggatcgc ccgctgcatg
      181 gcggggagcg cggtgttcat cgccgccatc gggccgcccg acatcgaccc ggacacgtcg
      241 atgagaaggc agacggggaa taccgcggga cgttccgatt gcgagaactg ggacacggga
      301 actccaattt cgtgcggacg cgcgagatgg gcatggaagt gaccggaagg gaaagggagg
      361 ggaatgccgg gcaatcggca tgaggaatgg agcggctcgc ggaacattcc gcgcctcgcg
      421 gctccgcatt cccctgatcg cgtccctcca ctatgcacga tcggggaggg tgatcgagcg
      481 ctgttttccg tatcgtgagg caattcccgg aggacgcccg gactgcgccc ggatcgcgcc
      541 cggcccgtgc ccgggccggg cgcccggcgg cttcagtccg cgggcgcgcc gacccgcgcg
      601 cagtacgggt ccaacgcgct gtcgagccag cgccggcccg cactgtcgtc gaggtcgatg
      661 ccgcccggga cggggcgcag gacctcgttc ccgtcctcgc ggaccagcgg gccgaagcgg
      721 tcgccgaaga gcaccgcggt gggctccgga tggttctgcc gggaggtcca gatcagcccc
      781 tgcgcccagt cggcctgccc gcgcagccag tggccccagc gccgggtgaa ggggtagtcg
      841 ggggattcgg actggatgag ccaggtgccc tggttgaccg cgctcgtcgc gcggcggtcg
      901 agcagcgaga gcagcgtgac gtcggtcagc agctccagcc gggacaggcg ccggtcctcg
      961 atggcgctgt acgagaccac gcgcggctcc ccgtcgtcga ccgggagctc cttcagcagg
     1021 ctctcgacga gggcggtctc ggcgctgggg gccaggtaga ggtaggagta ctcgtcgttg
     1081 ggggtgctgt cgaagcgggt gccgccgaag tggtggtcga ccacggtcgc gttgaagtcg
     1141 gccgccgatc ggctcttgcg gtgtacccgg tagagcgtcg tcccggcggg ccagaccacc
     1201 tggtgcggtg tgcccgcgag cttgccgggg agtttcgcag gacgtgccac gtcagtcccc
     1261 ctcgcccacg gcccgggccg cggccatcag ttcgtcgtcc gggacgctgc ccaggacctc
     1321 cgccggcggg gccgcgagcc agtggttggg ccccagccac cagtccgcgg cgccccacgg
     1381 gtccttggag gccctgagca cctcgttgat ggccaggacc agcggcaccg ggacgcagtc
     1441 ctcctggaac tggaacgacg gcagccgcac ctccccgccc ttacgcgtca gccggatcag
     1501 gtgcgggtgc cggggatcct gccgcagcac gtccctgacc tgggcctcgg aaagcgagga
     1561 ggcggagagc agccgctcgc ggatgcggtc ccacgaggag ggcgccgggg ggcccgccgg
     1621 ctcggcccgg tggtgcgaag gccgggcgcc cgaggaccgg acgggcacgt ggtggccgtg
     1681 ccgcgtggcc atccggcgga tgagcccggg cgccgccgac cggtcgggcg ccatggtcga
     1741 gcgccacctg cgcagggcgg ggtcgtcggc cgggagccgg gcgcgcacat gggccgccac
     1801 cgcctcgccg acggccctga gcccgtcgtc gtccgagacg ttcgcgaaca gtcccagcaa
     1861 acgatcgagc tgaatgcgat cagcttcggt caaacgttcg cgtatatcgt caggattcga
     1921 ttcgaggtcg gccagaatcg aaagatcaat atcgtccatg catcgttccc cctcacgcgc
     1981 ctgccagtac gttccgggac ggcaaagcgg tcgccacgag cgtactggaa aaaccggatc
     2041 ggtccactga gtgcgccatc catattgcca ggcacgtacc ccgccgggca gaatcgcagc
     2101 gtccccgcca cgccatcgtg aaggcaaggg gcaaagaagg ggatacgggg accgcgacgg
     2161 tccccggggg gagtcgggga tcgcggcacc gtgaacttcc ggtgccgcgg gaaaacaggc
     2221 tgacggcgga ccggcgtccg ctccggatcg tgaattccgg ccgccggacc gggccgtcgc
     2281 ggaagggcaa cggggggatc atggacgcgt cagagagcga cgacatccgg gcgctggagc
     2341 gggagatcgc cgcgctgcgc gagcgggccc gggtcctgca ccccggtggt caggagcgct
     2401 ggaacaccga agccgacctc gccgaactcc tgttcgtcca cgccctggag gtcgcctcgg
     2461 ccgaggcggc caccgccgcc ggggcgcccc cgctcccgga gggtctcgcc gaggcccgcg
     2521 ccctgctcga ccggctgctg tcccagcgcc gccccggcag cgcctcgtac cactgggcct
     2581 gcctgctcgc ggcccgcgcc gcccggggcg aggccgagct gaccggcgat ccggacgccc
     2641 gggacgcggc gatcgagcgg ttcgagaccg cgatcgcgcc gctgcccccg tacgggcccg
     2701 acaccttccc gccgctgccg ggcgaacccg agtggtggac gcccgccctg gccgtggacg
     2761 cccggtgcga gctgggcctc gccctgtaca accgcagccg cgagctcacc ggcgggagcc
     2821 ggtcccggga cctggaccgc atcgtcaccc ttctcacccc cgtggtggac ggccccgagg
     2881 ccgggctcgc ccaggacctc caggtgacac tggcctgtct gggactcgcc ctcgccgacc
     2941 gctcgcgcgc ccccggccac cgcggcccgg accggccggc cgaccgtacc gaggcgatcg
     3001 gcaggctccg cgccgcccgc gaggccccct cggaggacga ggtgccggga gccgtcccgt
     3061 tccagctggc gctgctcctc ttctgcgagc acgacgacgg ctgtggcggt tccgagggcg
     3121 ccgacggccg cggaccgtcc gcccggccga ccggggaact cgacgaagcg ctcgccctgc
     3181 tgtggccgct gaccctggat ccgtcggccg acggcggcga ggcgacggaa ctcgccacga
     3241 tgaccgcccg gcacctgtac gaacacgacg gcggtccggc cgccgagacg gccctgatcg
     3301 aatggcaccg cagggcgatc gaccaccccg gcacccagcg ccgccaagta cgtgccaacc
     3361 ggaccgactt ggcgctgctg ctcatcgacc gggccgagcg cggcgccacg gcgcccgccc
     3421 ccgggacgcc cgcccccggg acgcccagcc gctcggacga tctcggcgaa gccgcccggc
     3481 atctcgaact cgccctcgat gacctcgcct tgaaggagcg ggccccgtcc gtacggctgc
     3541 gggcggagga cgatccgccc gagaccgacg cggaccgagc cgaggaacgg ctcaacatgc
     3601 tcctcgggct cgtcacgctg ctcagcatgc tcctgcccga gagctccgac gacgcccggc
     3661 tcgaccgcct gatccgccgc gggcaggagc tgatcgaggt cattcccgac gccgacaccg
     3721 agcgcggcgg cgcctgcctc cggctcgccc tcgccctctt cgagcggacc tcccggcgca
     3781 ccctgccgca gctgcccgcc ctgctgatgc gcgcgatgac cccggaccgg gccgacccgg
     3841 ggatctccct cgtcgccaac gtcccggggg tacgggagga caacgagctg gcgatcgccc
     3901 tgctgcggac cggagtcggc ctctacggat acgaggacga gctctacgag gccgccgcca
     3961 tcgcgctggc ggtgagcctg ctcatcggct acacggtccg gctgcccgag cgggacaccg
     4021 cgctgatccg ggatgcggtg cgctggttcc gcatcgtcct cgaccgggtg cccgaaggcg
     4081 gcgagctcca cagcccggac ctggaggacc tgttcatcgg ggcgctgctc aacagcgtct
     4141 ggaccagcga gccgttcgta cgggcgcaga ccggctcgtg gcgcgacgga gaggggatcc
     4201 ccgacgtctc ccgcaaccag agcgtcgagg acgacctcca gagcctcagg cacctgctgg
     4261 agacggccgt gcgccgccgc gaacagcccg tgcccgtcta cgagatggtg ctcctgctga
     4321 tcaccttcat gcgcggcaag ggcgagctgg acgacgcgga ggcgcggcac tggcgcgacc
     4381 ggctccggcg ggcatcggcc tacaccgacc cggccgagga atcgctgaag ggcttcctgc
     4441 tgctggcggc cggggcgttc gggtacgagc tggcgcggcg cggagccgcc ggcccggccg
     4501 aactcgccga ggccgacagg ctgttgcgcg agggggcgcg ccacatgccg ccgggcagcg
     4561 acttcgcgga gtgggccgag gggctgcggg cgaccgggcc cgccacgctg atccagcagc
     4621 tgctgggcgt gttcatgggc ggtgcctcgg cctccggggc ggcagcggcg ggagcccccg
     4681 gcgcggcccg tcgcccggcg gacgatgccg tacgcgctcc cggccccgcg cgaccgccgg
     4741 gctccgcccg cccgccgggt cccgtccggc ccccggcccg gtcggcgccc gccgaggcgg
     4801 aggacatccc gctgtcggcc gcggcggtcc tgcccggaga cggcagcccg tgccccttca
     4861 ccgaacccgt gggccgcgtc ctcgaaatcg tcgccgggcc ggccgggccg gccgagcagc
     4921 ggtccgcccc cgtcatggcc gcgcacgccc tggcgctgca ccggcggtgg ctgcacgaga
     4981 gcgagatcgc cgacctcacc gacgccgtca ccctcacccg gcgggcgatc gccgccgcgg
     5041 agggcgccga cggccccctg gccgaccggc tgtcgctgct gctcgcgggc atgctgcgcg
     5101 accggtacct gctgatcggc gaccggatgg acctccacgc cgcccggacg gcgtacgagc
     5161 ggctgcgcga ccggtccgac ccgcgcgccc cgcaccccga gctcgccacg ctgctggcgc
     5221 ggcccggcgc cgaggggcag cccgacctcg cggccctgct gcggcccgcc cgcccggcgg
     5281 cccccggcgc cttctccgcc gagctcctcg cggccgcagc cctgaccgga ctgctcgccg
     5341 cccgcgcgga cggcgccgcc gaccgcgccg cggcggaact cgccgaagcc gccgaggcgc
     5401 tgccctccga ccaccccctg ctgcccgccg tactcagcga atcgggtctc ttccgcgcca
     5461 cccgggcggc ccgcgccgac gagctcgcgg ccctgcgcga ggccgtcgag gacgtcgtac
     5521 gggcggccgc cctctgcccg cccggcagcg cgcaccgggc gccgctgctg ctccgcgcgg
     5581 ccgccgtgct ctgcgcgcac agcgacgcgc tggacgcggc cgacccggcc ggccgcgccg
     5641 cccccggctc ccgtacgagc tccctcgacc gcggcatcgg cctgctgtcc ggcgcggtcg
     5701 acgaggcggg gccgagcttc cacggggccc gggcccgctg ccggtacggg ctggggagcc
     5761 tgctgctcac ccgcttccgg cgcagccgcg accgggccga cctcgaccgg gccgtcggcc
     5821 tcctccggga cgcccgcacg gccgtcctct cccgcccggg cgacccgttc acggtgctcc
     5881 tcacccgggc cctggccgag gcgctgcggg cccacggtcc cgaggacccg gaccaccgcg
     5941 cgcagtcccg ggaggcggcc aagtccgtcc tcgcggcgca cggccgggcg gtgctgctcc
     6001 agaccggcac cgagaccgcc ctcgactccg cccgcgcggc cggctccgac atgatgcgcc
     6061 tggtcgagtg gtgcctcacg gacggccgta cggaagaggc gctggaagcc ctggaactgg
     6121 ggcgcggact ggtgctgaac gcggcgaccg tcgccgcctc cgtacccgaa ctgctggagc
     6181 gggagggccg gccggagctg gcgcaggcgt ggcggcgggc cgatcccggc cgggtgcccg
     6241 gtacacctgc cgacggcccc gtggtcatcc ccgacggact gcggctgctc gtgctccagg
     6301 cgctggaggg cggcccggcg gaacgccgca tcctctccgc gcccacaccg gccgagatcg
     6361 gccgggcgct gcggacggtc ggtcacgacg cgctggtcca cctggtcccg ggccgggacg
     6421 ggtccggcga cgccctgatc gtgaccgcga ccggagcggt agagcggctg cggcttccgg
     6481 ggctgtgcgt caccgacgac ggcccggcgg ccgcgtacgg cgaggccctc caggagttcg
     6541 ccgcggccac ccgggagccg gtcgtgctgc cgggggagga cgacccggcc gtgatgtggg
     6601 agctctaccg gcgcggccgc aagcgcctcg gccgggcctc ggaccggtgg cgcggcgccc
     6661 tggaaccgct ctgctcctgg gccggcgaag tggcgatggc cgcggtgatc gagcacgtcg
     6721 gggcggggcg gcggcaccgg ccggcccggc tggtgctgtc cccggtgggc atgctcggga
     6781 tggtcccctg gcacgccgcg cgactgccgg gcgcgcccgg ggtgtccggg gagcccggcg
     6841 gcggctacgc ctgcggccgg gcggtgatct cgtactgctc cacgtcccgc cagctggtgg
     6901 aggtggcggc ccgggcgcgg ctgccgtgga acggcgcgca ggcggtggtc gccgacccgg
     6961 gcggcacccc ggccatgcac gaggaggccc ggctgatcgc ggcgctgtac ccgggggcca
     7021 ccgtcgtcgg gccggtcgac gacgtgcccg agccgggcgg ccccgggagc cgcccgccgt
     7081 cccggccggc cacggcggcg gcggtggcgc cgctgctgcc gggccgcggc gggtccagcg
     7141 ttgccgtctg ccacgtcaac tgccacgcca ccgcccgggc gacgccctcc gcgtccagcc
     7201 tcgacctgca ccccgccgcg cctgtgccgc aggtgctgac cctggcggag atccaggccc
     7261 tcgcccacgg ccgcgacccg tcggcgcccg gcggtctgct ggtcctcgcc aattgcacca
     7321 gcgacctgac cctggccgac tacgacgagg cgctgaccct gtcgacggcg ttcctcacgg
     7381 cgggagccgc ctcggtggtc ggctccctct gggcgatcgc cgacgacatc cgcacctcga
     7441 tggtgatgta cgtgttccac cactacctca ccggccgcgg actgcccggg cacccggagg
     7501 cggtgggctc gccggccgac gcgctgcgcg ccgcgcagct ctggatgctc gacccgcacc
     7561 ggatcgtccc gcccgcgctg tccgccgtac tggaagagcg tcccggactc gacctcgacg
     7621 ccccgcacat ctgggccgca tttacccacc acgggcactg acgtcactcc attaacgtat
     7681 tttgtcatgg cggtcgattt cagccacggt ttctgccacg ataatggcga gtaaagcctc
     7741 aaaggcgatc gggaaaaacc caggggggga aatgcggtga ggtacgatca agcggccatg
     7801 gtggcggccc tgaaattcgc ccacagcaat ctcgacggac tgaaagtcaa ggagctggtc
     7861 gacaagaagg gaatcgagtg gtacatcaac cactgcgccg cgctcgcggc gacgaccggt
     7921 gtggcgtcag ggatgggggg ccccgccacg atggtgctgg gcgtcccggc ggacatggcc
     7981 aacaccatcg cgcagcagtt ccgcgtcacg atggcggtga tctaccacaa gaccgggagc
     8041 tattcgcttt cgttcgatga attcatgaag atcgtggccg tgtcgctcgg ggtggaggtc
     8101 ggaacccagg tcgtcgtgcg ggtggcggcg gaaatcttca agcgactcac ggcgaagatc
     8161 gcggggaagt tcatccccct cctcggcggc gtcattggcg ggggcctgaa ttacggcttc
     8221 atcaaggctc agggaaaggc catgctcgcg ctggatttcg acaagttatc ccgttcggcg
     8281 tagctgggtg aggcgggcgg cccggcgtgt cagatggtcg cgctcggcga ggttggatgc
     8341 cttccgagcc gcctcggcgt acagccgggc cgccgtctcc aggtcgccgt cccgctcgtg
     8401 gaggtacgcc gccaccgcgg tgtggcgggg cagcgcgtcg tccagcgccg cgagcgccgc
     8461 cagcccggcg cgcggaccgt cggcctcgcc gacggccacc gcgcggttga gccggacgac
     8521 cgggctgtcc gtcaggcgta cgagctcgtc gtaccactcg acgatctgca cccagtcgct
     8581 ctccccggcg gtgggcgcgt cggcgtgcag tgccgcgatg gcggcctgag cctggaactc
     8641 gcccagccgg tcgcgggcca gggccgcctg caggatcgcg acgccctcgg cgatcatcac
     8701 ggtgtcccag cggccgcggt cctgctcggc gagcggtacg aggctgccgt cgggcccggt
     8761 ccgggcggag cgccgggcat ggtggagcag catgagggcg agcagccccg ccacctcggg
     8821 atggtcgatc gaggccgcga gctgccgggt gagccggatg gcctcggcgg cgaggtcgac
     8881 gtcgccggag tagccctcgt tgaagaccag gtagaggacg cgcagcacgg tggcgacatc
     8941 gccgggctgg tcgaaccgca ccccggagac ggtgcgcttg gcccggctga tgcgctgcgc
     9001 catggtcgcc tcgggcacca ggtaggcctg ggcgatctgg cgggtggtca gcccgcccac
     9061 ggcgcgcagc gtgagcgcga ccgcggacga gggcgtcagc gccgggtggg cgcacaggaa
     9121 gtacagctgg agcgtgtcgt ccacaccggg cgcgggtccc ggcgcgggct cctcctcgac
     9181 gaggtcctcg cgccggcgcc gggcggtgtc cgaccgggcc gcgtcgaggt accggcgcca
     9241 ggccacggtg accagccagc ccttcggctc ccgcggcatg tcggccggcc agacgcggac
     9301 cgcctcgacc agcgcctcct gcagggcgtc ctcggccgcc gcgaagtcgg ctccgcggcg
     9361 gacgaggatc ccgagcacgc tcggggtgag gctcctgagc aaggcctcgt tcatcggtga
     9421 ggtcactccg tgatggtggg cggcgcggtc aggaacgggc gcagttcgag ccactcgtgg
     9481 atcggcttcc cgcccgcccc gggggcggcg gacagctctc cggccagctc gacggcgcgc
     9541 tcgtaactgt cgacgtcgat caccatccag ccggcgatga ggtccttggt ctcggcgaac
     9601 gggccgtcgg tgacgggcgg gcggccctcg ccgtcgtacc ggacgaaggt ccccgtgggg
     9661 gcgagcgcct gaccgtcgac gaactcgccg gtcccctcca gccggtccgc gaagtcctgc
     9721 atgtaccgca tgtgggccga gatctcctcc ggcgtccact ggtccatggg gacgtcgttg
     9781 accgccgcgg gggcgccccg gtagtgcttg agaagcaggt acttggccat ggtggttctc
     9841 ctcgtacggg tgcggcccat tctggccgcg ttcaccccgg ggacggagcg ggccacgggt
     9901 tctcgacatc gccggcggaa ttttttcgcg gcatcccgcc agcccgcgca ccccacgcct
     9961 gccggcccgg cccccggccc ggtcgccgat actgatctcc atgcacgcca cggtcaacgc
    10021 cgccaccctg gaacgcgtcc tcgggcaccg gacccgcttc gacgcccggt tcgggcagta
    10081 cttcgacagc ctcgccgggc gcttcgacct gccggtgccg agccggtacg tcccccggtg
    10141 cctggacctc ctgcgggacc tctcgatgcg cggcggcaag cggctgcggg tcgtcctgct
    10201 gtacgaggcg gcccggctgg tcaccaccga ggaggtgccg gggctcgcgg aggccgccct
    10261 gagcatcgaa ctgctccaga cccacgggct cgtccacgac gacatcatcg acgacgcgcc
    10321 cctgcgccgc ggcggcccct cgacgtacta cgcctaccgc cgggagttcc ccggccacgg
    10381 ggccaccgcc ctcgggctcg cgctgctcgc cggtgacctc gccgggttcc tctccacgca
    10441 ggtcctgctg gaggccgagg cgcccgtcgc gctccgccag gccctgctcg gcgtacagac
    10501 gcgcaccgcc gcggagaccg tggccgggca gatcgccgac ctggagcggg acgcccacgc
    10561 gctgcccgac gaggaattcc tgcacaccgt caccgacttc aagagcgcgc ggtactcgat
    10621 cctcgcgccg ctgaccatgg gtctgctggc ggcgggcgag gatccggcgc cgcaccgggc
    10681 ccggctgcac cggtacgcca ggctggtggg catcagcgag cagatgcgcg acgactgcct
    10741 cgacctcttc ggcccgttcg gcgagggcgc gggctcggac gcggtcgcgg gcgcggctcc
    10801 cgcggtcgcg gacaagtcca ccggggccga catccgctcc ggccgccgca cctacgccgt
    10861 ccgcgcggtc ctggccgccg cgaccggggc cgacgccgcc ctcgtcgaag ccgcgctggg
    10921 cgatccccgc tgcccggacg ccaccctgga acggatccgg gagatcgccc gcgccgccgg
    10981 agtggacggc cggctgaagg cggagatccg gcgccacgcg gaggaggcgg ccgccgaggc
    11041 cgcgtcctgg gagccgtact ggcgggcgga ggccgtggag ctcttccggg gcctgccgat
    11101 gtggaacgtg gaccggatgc cctgagcgcc ctcacccggc gagggcgtcc acgcgggcgc
    11161 gggcaccctc accggcgccg tcaccggccg cctcgtcgaa gcccttgaac agcagccgga
    11221 ccgccagggt cacctcccag gcgaagacgg gcagggccgc gagcgaaccc gccacggaga
    11281 cctgctcgta gaccccgaac agcacggcgg tcgccgaggc gcagatcagc gcgccgccgg
    11341 ccagcccgag cacggcgacg gcccgcggca ccagccgcga ggtgtacagc aggcaggcca
    11401 gtaccagggt gttggccccg aggacgaagt tgggcccgag caggaacgtc cagtcgtgca
    11461 gcgccaccag ggccttcccg gccgtgacga gggaggcggc gtcggcggcg cccgacgggc
    11521 cggcggaccg tctcagcgtc acgaccgcca gcacgctgac gatgccgacc acgatgacgg
    11581 cggcctccag caggcgcccg cagacatagc cgacggcggc cgcttcgccg cgccgccgca
    11641 ggaccgggta cagcgcggcc ccggtgccca tgaccgccag cgcgagcacg agttcgcaca
    11701 gcgcccccag gaacacccgg gtctcggcgc cggatccgac gacgtagccg gggccgtcca
    11761 gaacggggcg gtagagcgcg agcccgccga tcgccgcgac ctccgtgacg aggaacaacg
    11821 cccccgcgac gaccgcgagc ctcctggttt cacccatgcg gaacagtccc tccctcgatg
    11881 ggtgtacggc gtacacccga catctggcgc tcacggtagg tgtacgtcgt acactcgtca
    11941 agacgggatg ccgtatccac gcccgcccgc cgggcggaag cgacgaccag ggagaaccga
    12001 catgccggcc gacgtgccag ccgaggagtc acgccggacc cccttgagcc gggaccgggt
    12061 gctgcgcgcc gccgtcgcct tcgccgacgg cgccgggatc gaggcgctga gcatgcgcag
    12121 gctcgcccag gaactgggcg tcgtgccgat ggcgctctac aagcacgtgg ccaacaagga
    12181 ggaactcctc gacggcatgg tggaggccgt cgtcgcggga ctcgaccccc atgtgccggg
    12241 agcggactgg aagagcgcgg tccgccgccg gatcctcggg gcccgcgagg ccctcgtgcg
    12301 gcacgcctgg gcggcacagg tgatccgctc gcgcaccagc ccgacaccgg ccgtgctcgc
    12361 gtacctggac tccgtgatcg ggatgttccg ggccggtggc ttctcgctcg acctcaccca
    12421 ccacgcgatg cacgccctcg gcagccgggt gctgggcctc accgaggaac tgttcgacgc
    12481 cccgccgagc cccggaccac gagcgacggc gacggcgtcg gtgtcagcgt cggcagcgga
    12541 cccggcgcag acggccgcgc gcgaggcgat ggccctgcgg tacccccatg tcaccgagct
    12601 ggccggggcg gtggcccatg accgcagttc cgtcgtgggg ggccggggct gcgacgaccg
    12661 gttcgagttc gagttcgcgc tggacctcct cctcgacgga ttcgaacgcc tccacgggca
    12721 gggctggaca tcggcccccc gtccgtgacg cggatccgca cggtgccgca ggatgggggc
    12781 atggagttcg cggaactgga ggagcgggcg cgtacgctcg cggcgtcggg cggcaggcgg
    12841 atcctcggga tcgccggacc gcccggagcg ggaaagtcga cactggccgc gcgcctcgcc
    12901 cgggccctcg gggccgaact ggccgtcgcc gtaccgatgg acgggttcca cctcgcgcag
    12961 gccgagctcg tccggctcgg ccgggcggac cgcaagggcg cgcccgacac cttcgacgcc
    13021 gccgggtacg cggccctgct gcggcggctg cgcgccgccc ccggggaggg ggccggggcg
    13081 gtctacgccc cggccttcga ccgggccctg gaagagccgg tcgccgggag catccgggtc
    13141 ggcccggccg tacgtctggt gatcaccgag ggcaactacc tgctgtacgg ggcgggggag
    13201 tgggcgcagg tacgcccgct cctcgacgag gcttggttcc tcgcccccga cgacgcggtc
    13261 cgcgtccggc ggctcgtcga ccgccacgtc cgtcacgggc gggaccgggc ggccgccgag
    13321 gagtgggtgt cccgctcgga cgagtcgaac gcccggctgg tcgccccggg ccgggcggga
    13381 gcggacctgg tgctggaatg aggcccgtta gggttgcccc gtgacagcgg agagcggagc
    13441 cctgatcggc gggcggtacc gactggttga gctccggggc cggggcggca tggggcgcgt
    13501 ctggcggggc ctggacgagc ggctggaccg tgaggtcgcc gtcaaggaga tcgtgttccc
    13561 ggacggcgtc gacgaggaac ggcgcgaggc cttgctccac cggttcgtgc gcgaggccag
    13621 ggcggcggcg cggctcaacg accccgggat catcacggtg cacgacgtgg tcgagcacga
    13681 gggcgctccc gtcatcgtca tggagtacgt gaccggccca tcgctcgcgg cccaagtggc
    13741 gcgcggcggg gggatgccgg tgcggcgcgt cgccgagctg ggcgtcctga tggtgaaggc
    13801 gctccggcgg gcgcacgccg cgggcatcgt ccaccgcgac ctcaagccgg acaacgtgct
    13861 gctcatggac gaccgggtga tcatcacgga cttcgggatc gcccacgtgg cggacgccac
    13921 gatgaccctc acccgcaccg gaacccttct cggcacgccc gcctacatgg cgcccgagca
    13981 gctggagggc gggcctccga cgcccgccac cgatctctgg tcgctcggcg ccacgctgta
    14041 ctgcgcgctg gaggggcggc cgccgttcgt cgccgagacc ttctccgccc tgtgcgtcgc
    14101 catcgtcatg caggaccctc cggtccccgg gcgggccggc ccgctggcgc ccgtactggc
    14161 cgcgctcctg acgaaggacc cggccgggcg ggccaccgcg gagcaggccc tggccgccct
    14221 ggaggccgtc gccgggggcg ccgcgcagcg ggagccgcaa ccgcaaccgc agcccccacc
    14281 gcagccccaa ccggagcagc ggcgccggca gcggctcccg gggtcgtcgc tgcgcggcgc
    14341 gggctgcttc gcactggtct ggctgggcac cctgctgccg tggaaccaca ttcgcgaatg
    14401 gcacggattc cagcgggagt tgctggtcgg cgcgacggcc gcggtggtgg ccctggcgaa
    14461 cgcgggcctg cggccccggg ggccggccgg accggggtgg gcgctgttcg ccgggctgaa
    14521 cctcgcactg ttcctggtgg cggccctgat ctggcccgtc tgggggctcc ccgccgtcat
    14581 cgccaacggg ctgctcgtgg gcaccgtctc ctggtcgctg tggtggtcgc tctcccgcgc
    14641 cggggtgccc gccggggtcc gccccgacgg cgtcagcgag cgaggaaccc ggtgacggcg
    14701 gcggcgaagg ccgccgcgtc gtccagccac ggatagtggc ccgctcccgg cagtacggtc
    14761 agctccgctt ccgggaagac accggcggcc cgcgcggccg cggccgccgt cggccagagg
    14821 tcacgctcac cggccagcag cagcaccggc gccgcgagcc gggcgagccg ggccgccagg
    14881 gcctcggtgt cgggggcgta cccggcgtag aaggcctcgc tgaccggtag cgaacgctgg
    14941 gccggatcgg cggcggcgtg cgcccgggcg gcggcgtccc accgcccgta catcagcggc
    15001 tcgtgggcgg gccggtgcgc ggccgcctcc tcgaaggagc gtgccgcctt cacggcccgg
    15061 taggccggga gggcccgcgc gtaccagggt tcggcggccc gcgaacgcag gacctcctcg
    15121 gcgccggtgt ccgagggcag cccgatcgag gcgaaggacg gggtgaccag caccagccgg
    15181 cgcagccgcc cgggatgggc ggcggcgtac agctgggcca gggatccgcc ggccgaatgg
    15241 cccagcaggt cgaaggtctc caggcccagg tggccgcgga gcgcctcgac atcggccacg
    15301 agccggtcga cccggcaggt ggcgaggtcc gcgggcatcg cggaggcgcc ggagccccgg
    15361 gtgtcgggga ggatcagggt ccggtgcgcg ccgaggccgc cgaggtcccc caggtaggcg
    15421 gcggcgcgac cggggccgcc gggcaggcag acgagcggcg gggcgccgcc gtcgccggtc
    15481 acccggtagg ccagctcggt accgtcgtac gaagtgaaga agtgcaggtc catgccgggt
    15541 agcctgcggg ccgccggcac cggccgacta ctgttcagcc agagctacat ggtcgggcgc
    15601 cggacgggcc cgccggacgg gggtggcggt gtccgtcgag atcaggctga cggcggcgga
    15661 ggtggcccgc gtcagattcg ccgtgtcgcc gctggccgag acggtgctgg gcgtgcgcgc
    15721 cgcgctgacg gccacgggcc aagccgtgca ccaccggtgg ctggccgagg cccgggacgt
    15781 actccgcgat gaccccgaac tgcctttgct gagaaacctg ctggggcact gcctgccgtc
    15841 gttcctgctc ccggtgccgc gtgaacggct gccctcgctg gacgaggagc tggccgacct
    15901 gtgcgccacg gatcccgcgt acttcgcggc cgaatgcgcc gccggcgccg gcgcgcgggc
    15961 cgcggggcgg cttccggccg ccgaggtcgc cctgccccgg ctggccggcg ccctgcggcg
    16021 ctgtcacgac cgtctggtgg ccccgcactg ggggcggatg cgggccgtcc tcgacgccga
    16081 tgtgggccgg cgcgccgtgg ccctcgtcga cggcggggtc gaggggctgt tcacgcagct
    16141 gcaccgcgac atcgcctggc gcgagggcga gttggtcgtc ggcggccggc gccgggccgg
    16201 cgccgcgccc tgcgcggtcg aagcctcggg gcacgggctg gtgctgctgc cctccgtgtt
    16261 cgcgtggccg gacgtactgg tcgaccgctc gccggtgaca gcggcctcca tccgctatcc
    16321 ggccctcggg gtcggcctgc tctgggagcc ggaccgcccc acccgcgacg gcctggccgc
    16381 cgtcctcggg gcgacccggg cggcgctgct ggccgcgctc gccgaaccgc tgaccacccc
    16441 ggcgctggcg gcccgcctcg gggtcacccc cagcgccgtc tcccagcacc tgggcgccct
    16501 gcgcggcgcg ggcctggtct ccacgcgccg gtccgggcgg acggccctgc acctgcgcac
    16561 cgcccgcgcg gtcgaccttc tgaccggctg agcccgccgc ggccgccccg gaccccgtcc
    16621 gggccggtgt cacccgtacc gctcgtgtcg ccccggggaa ccaggggaac gatcttccct
    16681 gcccgttcgt ctggattgcc caggactgtc cgtgtgcatg aggggagtac cgtcccatgg
    16741 cccgacccgc tccgacgccc gcccggtcgc ggcgacgccg tcgtatcgcg gtcgccgggg
    16801 ccgcgctgtg cgcgggcctg ttcgtgctgc tggcagtcct cgtcaccgcc cggcacggcg
    16861 ccccgtaccc gctggacagc gccgcgcacc gctggtccgt acggcaccgg cccgccgtcg
    16921 ccgtcgcgtt cgcgcgggcc gtcacctcga ccggcagcgg cccgttcccc tacgcgtgcg
    16981 ccgccgcggc gggggccatc gccgggcgcg gcacccgcga gcggctgtgg ggcgcggccg
    17041 ccgcgctgct cttcctcggc ttcgcccagg cggtccgctt cggtgtgctc cacctgatcg
    17101 gccggccccg gcctcccctc gcggaatggg ccaccgtggc ccacgaccac tccttcccct
    17161 ccggccacac cacggcctcc gccctcgcgg ccgggctgct ggcctgggcg ctcctgcgtc
    17221 gcgccggtcc cgccgccgcc gcgatcccct gcgtgatcct ggcgggctgg gccgtcgccg
    17281 tcgggctgac ccggatctac ctcggggtgc actggcccac ggatgtcctc gccggatggc
    17341 tctacgcgct cacctggttc gccgtcggct acgccgtctt cccgtacgtc ctgcggatgt
    17401 tcacggacac cgactgacac cgcacccgaa aggacgtggg ccgatgtggg ctgccgggga
    17461 ggcgtacgaa ccgtacgtcg gacggtggag ccggctggtc gccgccgagt tcgtccgccg
    17521 gctggccgcc gcgcccggcg gcagctggcg cgacatcggc tgcggtacgg gcgcggtcgc
    17581 ccgggccgtg ctggccgcgg ccgccccgcg ccgggtgatc ggcgtcgatc ccgcggagag
    17641 ctacgtacgc cacgcccgcc ggcacctcgc cggtccccgg gccgacttcg tcgtgggcga
    17701 cgcgctggcc ctgccgttcc ccgacgggcg ggcgacggcg gccgtcagcg ggctcgtgct
    17761 caacttcgtg ccggacccgg cgcgggcggc cgccgagatg gtgcgcgtcg tcgggcccgg
    17821 cgggacggtg gccgtctacc tctgggacta cggcgaaggc ggaatgcggg ccatccgtgc
    17881 gttctgggac gccgcccgcg cgctcgaccg gcgggccgag gccctggacg aggcggtcag
    17941 gttcccgctg gccggccgga agccgctgcg cgagctgctc accggcgccg ggctggcggg
    18001 ggtggagacc ggtgagatca ccgtaccgac ccggttcagg gacttcgacg actactgggg
    18061 gccgttcctg ggcggccagg gccccgcgcc cgcctatgtg gcctcgctgc ccgaggacca
    18121 ccgcgcggag ctgcgggaac ggctgcgcgc caccctgccc cgggcctgcg acggctcgat
    18181 ccgcctgacc gcgcgggcct ggacggcgtg gggtgcgcgg ccgccgggct gagcccggtc
    18241 acccgtcggc cgcagaggca gcgcgagggc ccagcgcgag ggcccagcgc gagagcccgg
    18301 tgggaacgtc ccaccgggcc ctcgcggggt cattcggacg gcgtgccgaa ggcgtgcacc
    18361 gccctgctga acgcggtcat gcaaggcgcg cagtagcgct cggcggcggg gtcggcctcc
    18421 ggtggagggg tctggtcggg gttgaggagg gatccacaca gggtgctgaa ggtcgtgtcc
    18481 ttcgctatga cgtgccacag gagctggcat cggtcggcta tggactcggc gcgcatctcg
    18541 tacatgggcg tacctttccg cgctagcgcg ggcagaggaa cggaaccggc ctgttgtcca
    18601 tgagagcccc ccgtgacgaa tgcggccaat gtgggtagac caacagaagg aaaaccagtt
    18661 ggagcaggtt tggccgagca gggaggagac cgtcgatggc atgggcttcg tggacgacga
    18721 caggggtctt tccgggggcc ggaggggtcc ggaccgagga ggtcgggatc atttcgggag
    18781 acctgaccgt gcacaccacc tggacgggcg cccaagccca ggtggcggtg cagtacagca
    18841 gctcgtcgga ctggttcacc ctgtccggca gccccgtgga atgcgtgtcg gaaccggaga
    18901 gccgggacct gcaccaggcc gtggtggagg cggtccgtgg tggaggcggc agcggcgttc
    18961 caccccattg ggccactttc gcggcctgac ggacacagcc tgataacgcc tcgcgacctc
    19021 ccggagtgga ggatcgttca gccttgtatg aaagccatga gtcccggggc cacgatgccc
    19081 gccaccctcc ccgcccgtcc gcggccaccc gcagccacgg cggcggcggg tggccggccg
    19141 gacacggtca ccgccacggg cacgccgatc tacgacgcgc tcatcgcgca gtggtcccgg
    19201 gagggccgtg agctccccct gggcatagaa ccgaccggcc gcacccccgt gccctccccc
    19261 tcgcgtcagt tcgcggccca gccgccgtcc agcggcaggg agatcccggt gatgtagccg
    19321 gtgtggggcc cgcacagcca gagcgcggcc gccgccacct cctcgggctc gatcagccgt
    19381 ttgatcgcgg accgggtcag cagcacgtcc gccaccacgt ccgcggcgcc gatgccgtgc
    19441 gcggcggcct ggtccgcgat ctggccctcc accagggggg tgcgcacata gccggggctg
    19501 acgcagttgc tggtcacccc gtacggggcc ccctccaggg cggtgacctt gctcagcccc
    19561 tccagcccgt gcttggccgc gacgtaggcg gatttgtagg cgctggcccg cagcccgtgg
    19621 acgctggaga tgttgaccac ccggccccac cccgaggcgt acatgtgcgg cagcacccgg
    19681 cgcagcagca ggaacggcgc ggtgaccatc acccgctgga tcagggcgaa gcgctcgacg
    19741 gggaactgcg tgatcggcgc cacgtgctgg agccccgcgc tgttgaccag gatgtccaca
    19801 tgggcgggca gctcctcgat ggccgccggg tcggcgaggt cggtcacgtg cgcccgcccc
    19861 cggacgagac gggccacgga cgccgccgaa ggcgcgtcga cgtccacgac gtgcacggcg
    19921 gcgcccgccg ccgccagggc caccgcgcag gcccggccga ttccgctgcc gccaccggtc
    19981 accaaagcga cgcgcccccg caggtccacc cccgcggggc cgggcgcggg caggggaagc
    20041 gcgggaggaa gtttgctcgt catggttcgc aacagtaagg acggcccgcc cgcgcgccca
    20101 tggcgtggcg caccacactc ccggccgggg cagtgtcggc ggccgccata cggggcggga
    20161 gtccgccgtc ccccgggagc cggggccgct caggcatggt gcgcgggccc cgtcgtcttc
    20221 tacggtgcct ccagcactca ccacctggag gcaccgtatg acccctgaca tagacaccgc
    20281 cgagctcgtc gccgccgtca acaccgtcga gcgggcccgc cacctgttgg gggaagcccg
    20341 cgacgagctc ggcggggcgg gggtgtcgcg ggaccaggag tggacggccg cgggaagccc
    20401 ggtgcagacg ctccagggcg ccgatgacat gcaccggggg tccggtcagt tcctggacga
    20461 tctcgccctg gccctgggct acgccgccgc gggcctggcc gagcaggccc tgcgtcagcg
    20521 cgagcgcgcc ggccaggggt tcctcgggct gagcggtgcg gaccggatgg cccggccgct
    20581 gcccgcgccg acggtcgagg ccctcgaact cctgcgcggc ctggacctgc tcaccccgga
    20641 gttccgcgaa cggatcacgg gggcgctgga ggcggaggcc gccacctacc cggatccggc
    20701 gccgcagcgg cccctgcggc tgggcacctc cgggctcacc ccgacggccg gctgaccgcc
    20761 ccgctcaggg ggagccgggg cggcgggccc gggtcggctg ggcgagggac tgctggccgc
    20821 ccgagggcag catccgtacc tcgccctggt cgctgatctc cgcccgtacg atcccggtgg
    20881 agtcggcgta gaccggatgg ccgcccggcc ccttctgcgc ggtgcgcgag acgaccacga
    20941 ggtcctcgcc ctcgctctcg ggctcgccgc tgccgaacac cagctcgtag cggtcctcgt
    21001 ggtcctcgct caccgatgtg cctcccggtc cgcgccgccg gcccgcgccg acggactgtc
    21061 accaacctgc accatcggat gccggggccg gacacaccac gcggtactca ggtccgacca
    21121 gggga
//
