LOCUS       NZ_CP011664            11356 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 chromosome 1, complete sequence.
ACCESSION   NZ_CP011664
VERSION     NZ_CP011664.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6103525
            Orig. end                         :: 6114881
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011664.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11356
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="18"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11356
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6356](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6356)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1322..2035
                     /gene="hemQ"
                     /locus_tag="M444_RS26550"
                     /old_locus_tag="M444_26530"
     CDS             1322..2035
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072526.1"
                     /locus_tag="M444_RS26550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26530"
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_037798306.1"
                     /transl_table=11
                     /translation="MTAPEKIPNAGKKAKDLNEVIRYTLWSVFKLKDVLPQDRAGFADE
                     VQELFDQLAAKDITVRGTYDVSGLRADADIMIWWHAETSDELQTAYNLFRRTRLGRALE
                     PVWSNMALHRPAEFNKSHIPAFLADEVERDYVSVYPFVRSYDWYLLPDEDRRRMLADHG
                     KMARGYPDVRANTVASFSLGDYEWILAFEADELYRIVDLMRHLRASEARMHVREEVPFY
                     TGRRKSVADLVDGLA"
     gene            complement(2150..3805)
                     /locus_tag="M444_RS26555"
                     /old_locus_tag="M444_26535"
     CDS             complement(2150..3805)
                     /NRPS_PKS="Domain: Abhydrolase_1 (109-477). E-value:
                     5.8e-23. Score: 73.7. Matches aSDomain:
                     nrpspksdomains_M444_RS26555_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018888542.1"
                     /locus_tag="M444_RS26555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26535"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_107082568.1"
                     /sec_met_domain="PF00561 (E-value: 9.6e-29, bitscore: 99.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLVRPAVAATALAFALTLTLAPPAPASAPATAVAAENAGAERVA
                     RRAAAGHRALDFRSCPAAEGLAAPVRCAALRVPLDYARPDGPQISLTVSRVGATREGRA
                     ARQGSLVFNPGGPGASGMYFPLLADRPAWRRVAAAYDLVGYAPRGVGRSAPLSCQDPAA
                     RPKAPTQVPADPSAAYKRERVAAARAYARGCARRGGAALPYYTTLNNARDLHVLRAALG
                     ERELTFVGASYGTYLGAVYATLYPGHVRRMVFDSAVDPDPRHVWYRDNLAQAAGFERRW
                     YDFRAWAARHDATYRLGATPAAVRASHERVRAAVARTPAGGVAGTGELRAAALRAAYYD
                     EVWPELAAALSAFLDGDPAPLAALAGPDPDPVAAARAAAEAENATALYTAVLCNDAPWP
                     ADWETWDRDHTELARRAPLETWANAFLNLPCAYWPVAQRLRQRPLDVGSRATPLPPTLI
                     VAAERDGATPYPGALELRRRLGGAAALVTEAGAGAHGVAGGRNDCVDRHVERYILTGDT
                     PKGSVTCAPHPEPAPVSLDDRAAGTRRVPLPPVV"
     aSDomain        complement(2375..3478)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M444_RS26555_Abhydrolase_1.1"
                     /evalue="5.80E-23"
                     /label="M444_RS26555_Abhydrolase_1.1"
                     /locus_tag="M444_RS26555"
                     /protein_end="477"
                     /protein_start="109"
                     /score="73.7"
                     /tool="antismash"
                     /translation="LVFNPGGPGASGMYFPLLADRPAWRRVAAAYDLVGYAPRGVGRSA
                     PLSCQDPAARPKAPTQVPADPSAAYKRERVAAARAYARGCARRGGAALPYYTTLNNARD
                     LHVLRAALGERELTFVGASYGTYLGAVYATLYPGHVRRMVFDSAVDPDPRHVWYRDNLA
                     QAAGFERRWYDFRAWAARHDATYRLGATPAAVRASHERVRAAVARTPAGGVAGTGELRA
                     AALRAAYYDEVWPELAAALSAFLDGDPAPLAALAGPDPDPVAAARAAAEAENATALYTA
                     VLCNDAPWPADWETWDRDHTELARRAPLETWANAFLNLPCAYWPVAQRLRQRPLDVGSR
                     ATPLPPTLIVAAERDGATPYPGALELRR"
     gene            complement(3925..5004)
                     /locus_tag="M444_RS26560"
                     /old_locus_tag="M444_26540"
     CDS             complement(3925..5004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018100704.1"
                     /locus_tag="M444_RS26560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26540"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_053065806.1"
                     /transl_table=11
                     /translation="MNLLAWAVWIVVITSTVLLLRGLRRSRPAPGGPAHPPLDLSEAAF
                     MAGGPGAVVDAALVSLLGDQRMVAGGPGIVQVRPGARAVDVAERAVLQAYANAPSGWLY
                     QVRYAAMTDPAIQEIGDALAERGLISPPGAARRWRRWGLAQAVLCGALLPVSLVLTFVG
                     FALEPGFQLPFLVKVFPVLIGGLVVGVAAAARAKRRITPAGRTALRAMRATHLTDQTPH
                     VQTALFGLRGLRDPYLREQLVPAARSTRLAAAQAGQRRSAGSPGSRSSWGSSSADALPV
                     VWCASVDGGSGGGSSGCGGSSGCGGSSGSGCGSSGSGCGSSGSGCGSSGSGCGSSSSSC
                     SSGGGSSCGSSSSSCSSSS"
     gene            complement(5001..6356)
                     /locus_tag="M444_RS26565"
                     /old_locus_tag="M444_26545"
     CDS             complement(5001..6356)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267201.1"
                     /locus_tag="M444_RS26565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26545"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_047960733.1"
                     /sec_met_domain="DUF692 (E-value: 6.3e-90, bitscore: 299.7,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPMAHLGVGIGWRPEIADAVERLPGLDWVEVVAENICPGHLPAS
                     LLRLRERGVRVVPHGVSLGLGGAHRPDPEKLAALGERAVALGAPLVTEHIAFVRTTTPA
                     PALEAGHLLPVPRTRDALDVLCENVRIAQDALPVPLALENIAALISWPGEEMTEGRFLS
                     ELVERTGVRLLIDVANLHTNRVNRGEDPAAVLDAIPLEALAYVHVAGGFERDGVWHDTH
                     AHPVPGVVLDVLAQLRRRVDPPGVLLERDDDFPPEGELAGELEAIRGVLDPAGSRPSAS
                     LRTPSRDCAAEPTPDPVPDATPEPAPVPAADPVPDAARTRVGLAQAALLSALVAGTPVP
                     EGFDRQRIRVQSRSLAAKRAGVVAKVAPELPGILGGEKAYREAFLAYARNRPMTGGYRR
                     DALDFAEHLLIRELPADPADRRRLTAWWQERAGTRPARRIVRWARALVGRAA"
     gene            complement(6471..7238)
                     /locus_tag="M444_RS26570"
                     /old_locus_tag="M444_26550"
     CDS             complement(6471..7238)
                     /EC_number="3.1.1.29"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267202.1"
                     /locus_tag="M444_RS26570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26550"
                     /product="aminoacyl-tRNA hydrolase"
                     /protein_id="WP_235441280.1"
                     /transl_table=11
                     /translation="MNSAMSSPDTHHDDSTPVPAAGAEHPPRPQRSARDEAPQFVLPLV
                     VRIEKAEPPARTDALETAARAVLVLLSDERALGEGEWAGAVRDWQDARIRKVVRRARGA
                     EWRKAETLPGVTVHGDAAEVRVFPPVPLDGWPKELAKLQVSGTDLDDPEPVAPAPDGIA
                     VLWLNPDLEMSAGKAMAQAGHAAQLAWWELTGAERTAWRDSGFRLAVRTAPRERWARLS
                     GSGLPVVRDAGFTEIAPGSATVVSDHPALRARL"
     gene            7334..8008
                     /locus_tag="M444_RS26575"
                     /old_locus_tag="M444_26555"
     CDS             7334..8008
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014153329.1"
                     /locus_tag="M444_RS26575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26555"
                     /product="AIM24 family protein"
                     /protein_id="WP_037798308.1"
                     /transl_table=11
                     /translation="MKSDLFASEHLAQPSAAPGMTLQNAKSVKYTVNGEMLARQGSMVA
                     FRGNLQFERKGQGIGGMLKRAVTGEGLALMSVRGQGDAWFAHQAGNCFIIDFEPGDALT
                     INGRNVLCFDPTLSYEIKMVKGAGMTGGGLFNSVFTGTGKLAVVCDGHPIIIPVTAQNP
                     VYVDTDAVVGWSAQLETGLHRSQSVGSMIRGGSGEAVQLMLRGEGFVIVRPSELTETAA
                     AH"
     gene            8050..8865
                     /locus_tag="M444_RS26580"
                     /old_locus_tag="M444_26560"
     CDS             8050..8865
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007267204.1"
                     /locus_tag="M444_RS26580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26560"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_037798309.1"
                     /transl_table=11
                     /translation="MRLDAVGRRYGVRGPWVLRGVSLELPPGALVRVEGRNGGGKSTLL
                     RLVAGIDTPTQGSITGRPRRTAYVPERFPAVLPLTAQAYLGHLGRVHGLTRAEAARRAA
                     QWLERFGAAGHARTPLAELSKGTSQKVAVAQALLAGPGLLVLDEAWTGLDVPARAELDR
                     AVAERTAAGGTVLFVDHDPARLAGAPDRHYRVEGGALEPVRPGAGPGPRVRIEAAGPPG
                     AVPPPGLAAEPLPAGGFRLTVPAGRSDAVLRELLTAHPAWHIRNVSDLP"
     gene            8862..9500
                     /locus_tag="M444_RS26585"
                     /old_locus_tag="M444_26565"
     CDS             8862..9500
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007452202.1"
                     /locus_tag="M444_RS26585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26565"
                     /product="hypothetical protein"
                     /protein_id="WP_037798310.1"
                     /transl_table=11
                     /translation="MTALLRYQSALLLRSQRWLAPVLLYAAFLAVGFRPGDPVPDSLGY
                     SAAALVPVTAWLVRICLSVEPDAARDCAAAAAGPVRVHAAALLTGLGWGAGAGSLGAVA
                     VLLLGAREGPRLPAAALAGAASVLVCALTGAAVGALCARPLLRAPGYAVAAAGLGSLLA
                     LVTAGSPARVAVSGLVGGSVALPLGALAGAAALACAAGAAACLAAARRG"
     gene            9514..9705
                     /locus_tag="M444_RS26590"
                     /old_locus_tag="M444_26570"
     CDS             9514..9705
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997022.1"
                     /locus_tag="M444_RS26590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26570"
                     /product="hypothetical protein"
                     /protein_id="WP_037798312.1"
                     /transl_table=11
                     /translation="MDQSEPTESYCPAPAAPARVVAGPPYADCLECGKPTEYGVRTPGV
                     VLCPVCEWQEAQRTACSG"
     gene            complement(9728..10660)
                     /locus_tag="M444_RS26595"
                     /old_locus_tag="M444_26575"
     CDS             complement(9728..10660)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012378550.1"
                     /locus_tag="M444_RS26595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_26575"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_037798315.1"
                     /transl_table=11
                     /translation="MTSSLRKAAAAAVLSGALGAVLAGCGGGAGPSNGGAGQARLGASA
                     TPSASASASARASAPAPAAGAASALPRAGAPGKAPTLAPGPGGLTPVFERARQKTEKTV
                     ALTFDADMTSDQGPRAAGGEHFDNPQLIDTLRALKVPSTVFMTGRWAEEYPDQAKAIGT
                     DPNFEIANHSYSHHAFKSPCYGLPTLDGAAARADVDRAFDAFRKAGAVNTVPYFRFPGG
                     CYDDQALRALSTAKVTAVQWDVVSGDAFAKDPDAVAEQVLAGVKPGSLVVMHCTRSAAP
                     VTEEAIRTIVPELRKRGYRFVKVSELMGT"
     misc_feature    complement(10665..10674)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 12.62"
                     /tool="antismash"
     misc_feature    complement(10668..10682)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.73"
                     /tool="antismash"
ORIGIN
        1 gtgaaatcgc cggcgccccc gtcgacctcg gcgccgaatc cgtgctcgcc cgccgccccg
       61 aagccgtggc gctcgcccgg gccgtcggcc tcggcgaggc cctccagccg cccgccaccg
      121 ccaccgccca gctgtggacc cggggcgcgc tgcggcccat gccgcgcggc catgtcatgg
      181 gcgtccccgg cgacttggcg ccgctcgccg cctccggggt gctctccgcc gagggcctgg
      241 cccggatcga ggccgagcgc gcgctgccgc ccgccgagat cggcgaggac atcgccatcg
      301 gcgcgtacgt cgccgaccgg ttcggccgcg aggtcgtcga ccggctcgtc gaaccgctgc
      361 tcggcggcgt ctacgcgggc aacgcctacc ggatctccat gcgggccgcc gtgccccagc
      421 tcttcgaggc cgcccgcacg cacccgctgc tcggcgacgg cgtacgggac atccagcgcc
      481 gcgccgcgga gcagccccgg gcgggcggcc ccgtgttcgc cggcatcgac ggcggcatcg
      541 ggcgcctccc gctcgccgtg gcgcgggcct gccgcgaggc cggggcgcgg atcagcaccg
      601 ggaccccggt gcgcgagttc ttccggacca ccgcgggctg gcgggtcgtc gccgacggcg
      661 gcgaggtcat cgacgccgac gccgtggtcc tcgccacccc ggccgggccc gccgcccggc
      721 tgctggacgc gctcgcgccg gccgccgccg ccgagctgcg caccgtcgag tacgcctcga
      781 tggccctggt cacgatggcc ttccggcgct ccgagctgcc cgccgcgatc gccgggggcg
      841 gggccagcgg attcctcgta ccgcccgtgg acggccgtac gatcaaggcg tccaccttct
      901 ccagcaacaa gtgggcctgg gcgggcgccg accccgatct gttcctgctg cgcacctcgg
      961 tgggccgcca cggcgacgag gccgacctcg gccgggacga cgccgatctg gtggaggtct
     1021 ccctgcggga cctcggcgag gccgtcggcc tggcggcccg gccggtggcc tccaccgtca
     1081 cccgctggga cggcgggctg ccccagtacc cggtgggcca cctggcccgc gtggaccgga
     1141 tccgggccgc cgtcgcggcc ctgccgggcc tcgccgtgtg cggcgccctc tacgacggcg
     1201 tgggcatccc cgcctgcgtg gcgagtgcca cccgggccgc cgacgtggtg atggccacgt
     1261 tgggcgcccc gttgggcacc cctggcgccg accactgatc agcacacggg acaatggaca
     1321 catgactgca ccagagaaga ttcccaacgc ggggaagaag gcgaaggacc tcaacgaggt
     1381 catccgctac accctgtggt ccgtcttcaa gctgaaggac gtcctgccgc aggaccgcgc
     1441 cggtttcgcc gacgaggtcc aggagctgtt cgaccagctg gccgccaagg acatcaccgt
     1501 ccgcggcacc tatgacgtct ccggcctgcg cgccgacgcg gacatcatga tctggtggca
     1561 cgccgagacc tcggacgagc tgcagaccgc ctacaacctg ttccgccgca cccggctcgg
     1621 ccgcgcgctg gagccggtgt ggtcgaacat ggccctgcac cgcccggccg agttcaacaa
     1681 gtcgcacatc ccggctttcc tggccgacga ggtcgagcgc gactacgtca gcgtctaccc
     1741 gttcgtgcgc tcgtacgact ggtacctgct gcccgacgag gaccgtcgcc ggatgctcgc
     1801 cgaccacggc aagatggccc gcggctaccc ggacgtgcgc gccaacaccg tcgcgtcctt
     1861 ctcgctgggc gactacgagt ggatcctggc cttcgaggcc gacgagctgt accgcatcgt
     1921 cgacctgatg cgtcacctgc gcgcctccga ggcccgtatg cacgtccgcg aagaggtgcc
     1981 cttctacacc gggcgccgca agtccgtcgc cgatctggtg gacgggctcg cctgagacct
     2041 cccctggggg gaaggaccgg aagaccgctc tcgtgactga ggaggggctt ccggtggatc
     2101 gggaggcctt gcccccgaaa cgacgcagcc ggagatcccg cccggaagtt cagacaactg
     2161 gcggcagcgg taccctgcgg gtgcccgctg cccggtcgtc cagcgacacc ggtgcgggct
     2221 ccggatgcgg cgcacacgtg acactcccct tgggggtgtc accggtcagg atgtaccgct
     2281 ccacgtgccg gtccacgcag tcgttgcgtc cgccggccac tccgtgggcg ccggcaccgg
     2341 cctccgtgac cagcgcggcc gctccgccga gccgccgcct cagctccagc gcacccgggt
     2401 acggggtcgc gccgtcccgc tccgccgcga cgatcagcgt cggcggcagg ggagtcgccc
     2461 gcgagcccac gtcgagcggg cgctgccgca ggcgctgcgc caccggccag tacgcgcacg
     2521 gcaggttcag gaaggcgttc gcccaggtct ccaggggagc ccggcgggcc agttcggtgt
     2581 ggtcgcggtc ccaggtctcc cagtcggcgg gccagggggc gtcgttgcac agcaccgccg
     2641 tgtagagcgc cgtggcgttc tcggcctcgg ccgccgcgcg cgccgccgcc accgggtccg
     2701 ggtcgggccc ggccagggcg gccagcgggg ccggatcgcc gtccaggaag gcgctcaggg
     2761 cagccgccag ctccggccag acctcgtcgt agtacgcggc ccggagggcg gccgcccgca
     2821 gttcgccggt gccggccacc ccgcccgccg gagtgcgggc caccgccgcc cggacgcgct
     2881 cgtgactggc ccgcacggcg gccggggtgg caccgaggcg gtacgtggcg tcgtgccggg
     2941 ccgcccaggc gcggaagtcg taccagcggc gctcgaaccc cgccgcctgg gcgaggttgt
     3001 cgcggtacca gacgtgccgc gggtccgggt cgaccgccga gtcgaagacc atccggcgca
     3061 cgtggccggg gtagagcgtg gcgtacaccg ccccgaggta ggtgccgtag gaggcgccca
     3121 cgaaggtcag ctcccgctcg ccgagcgcgg cgcgcagcac gtgcaggtcc cgggcgttgt
     3181 tgagggtcgt gtagtacggg agggccgcgc cgccccttcg cgcgcagccg cgggcgtagg
     3241 cccgggcggc ggcgacgcgc tccctcttgt acgcggccga ggggtccgcc gggacctggg
     3301 tgggggcctt ggggcgggcc gccgggtcct ggcaggacag cggggcggag cggccgacgc
     3361 cgcgcggggc gtagccgacg aggtcgtagg cggcggcgac gcggcgccag gcggggcggt
     3421 cggcgagcag cgggaagtac atgccggagg cgcccggtcc gccggggttg aagacgaggg
     3481 agccctggcg ggcggcgcgg ccctcgcggg tggcgccgac ccggctgacg gtgagggaga
     3541 tctgcggtcc gtcgggccgg gcgtagtcga gcgggacgcg cagggcggcg caccggacgg
     3601 gggcggccag cccctcggcg gcggggcagc tccggaagtc gagcgcccgg tgaccggccg
     3661 cggcgcggcg ggcgacgcgc tcggccccgg cgttctcggc cgcgaccgcg gtggcggggg
     3721 ccgacgccgg ggccggtggg gcgagggtga gggtcagggc gaaggcgagg gccgtcgcgg
     3781 cgacggcggg gcgtacgagc ggcatccgca tggcggcccc ttcatctcgt cggctggtcc
     3841 gatgagattc cggggccgcc tcccggccaa ggagcaccgc cgggtgtcgt ccgtgattgc
     3901 ccccgttgcc gtagcgcgga cgggtcagga gctgctggag cagctggagc tcgacgatcc
     3961 gcagctcgaa ccgccgccgc tggagcagct gctggaggag gagccgcagc cggaccccga
     4021 agacccgcag ccggagcccg acgaaccgca gccggagccc gacgaaccac agccggatcc
     4081 ggagctcccg ccgcagccgg agctcccgcc gcagccgctg gagccgccgc cggacccgcc
     4141 gtcgacgctc gcgcaccaca cgaccggcag cgcgtcggcg gaggaagacc cccacgagga
     4201 acgggagccc ggggaaccgg cggagcggcg ctgccccgcc tgggccgccg ccagccgggt
     4261 gctgcgggcg gccggcacca gctgctcgcg caggtacggg tcacgcagcc cccgcagccc
     4321 gaacagggcc gtctgcacgt gcggggtctg gtccgtcaga tgggtggccc gcatcgcgcg
     4381 cagcgccgtc cgccccgccg gggtgatccg ccgcttggcc cgcgcggcgg cggcgacgcc
     4441 cacgacgagc ccgccgatca gcacggggaa caccttgacg aggaacggca gctggaaccc
     4501 gggctccagc gcgaacccga cgaaggtcag caccagcgag accggcagca gcgccccgca
     4561 cagcacggcc tgggccagac cccagcgccg ccaccgccgc gcggcgccgg gcgggctgat
     4621 cagcccgcgc tcggcgagcg cgtccccgat ctcctggatc gcggggtcgg tcatggccgc
     4681 gtaccgcacc tggtagagcc agcccgacgg cgcgttcgcg tacgcctgga ggacggcgcg
     4741 ctccgcgacg tccacggccc gcgccccggg ccgtacctgc acgatgcccg ggccgccggc
     4801 caccatccgc tggtcgccca gcagggagac gagcgcggcg tcgaccacgg cgccggggcc
     4861 gcccgccatg aaggcggcct cggacaggtc gagcgggggg tgcgcggggc cgcccggcgc
     4921 gggccgggag cggcgcaggc cgcgcagcag cagcaccgtg gaggtgatga cgacgatcca
     4981 gaccgcccag gcgaggaggt tcatgccgct ctccccacca gggcccgggc ccagcgcacg
     5041 atccggcggg ccgggcgcgt cccggcccgc tcctgccacc aggcggtgag ccggcgccgg
     5101 tcggcggggt cggccggcag ctcccggatc agcaggtgct cggcgaagtc cagcgcgtcg
     5161 cggcggtatc cgccggtcat ggggcggttg cgggcgtacg cgaggaacgc ctcgcggtac
     5221 gccttctcgc cgcccaggat gccggggagc tccggcgcca ccttggccac gaccccggcc
     5281 cgcttggcgg ccagcgaccg cgactgcacc cggatccgct gccggtcgaa gccctcgggc
     5341 accggcgtcc ccgccaccag cgcggacagc agcgcggcct gcgccagccc gacccgggtc
     5401 cgcgcggcgt ccggcacggg gtccgccgcg ggtaccggcg cgggctccgg cgtggcgtcc
     5461 ggcacggggt ccggcgtggg ctccgccgcg cagtcccggg aaggggtgcg gagggaggcg
     5521 gaaggacggg atcccgcggg gtccagcacg ccccggatcg cctccagttc cccggcgagc
     5581 tcgccctccg gcgggaagtc gtcgtcccgc tccagcagca cgcccggcgg gtccacccgc
     5641 cgccgcagct gcgcgagtac gtccagcacc acgcccggca cggggtgcgc gtgggtgtcg
     5701 tgccacacgc cgtcccgctc gaacccgccc gcgacgtgca cgtacgccag cgcctccagc
     5761 gggatagcgt ccagtacggc ggccgggtcc tcgccccggt tcacccggtt cgtgtgcagg
     5821 ttcgccacgt cgatcagcag ccgcacaccg gtgcgctcga ccagctccga caggaaccgg
     5881 ccctccgtca tctcctcccc gggccacgag atcagcgcgg cgatgttctc cagcgccagc
     5941 ggcaccggca gcgcgtcctg cgcgatccgc acgttctcgc acagcacgtc cagcgcgtcc
     6001 cgggtccgcg gcaccggcag caggtgcccc gcctccaagg ccggcgcggg cgtcgtggtc
     6061 cgtacgaacg cgatgtgctc ggtgaccagc ggcgccccca gcgccaccgc ccgctcgccg
     6121 agcgcggcca gcttctccgg gtcgggccgg tgcgcgccgc cgaggcccag cgagacgccg
     6181 tgcggtacga cccggacacc gcgctcgcgc agccgcagca gcgaagccgg cagatggccc
     6241 gggcagatgt tctcggccac gacctcgacc cagtccagcc ccggcagccg ctccacggcg
     6301 tccgcgatct ccggccgcca gccgatgccc acccccaggt gtgccatggg cttcatgtcc
     6361 cctcgccccc ctcatcggtc cgtgtgccca tgtcatcgcc acggccgggg cgggccaacc
     6421 accgccgccg gacgttcaga ggaacatttg aggttccgga ggtcccgccc tcacagccgg
     6481 gcccgcagcg ccggatggtc cgagaccacc gtggcgctgc cgggcgcgat ctccgtgaaa
     6541 ccggcgtccc gtacgaccgg cagaccgctc ccgctcagcc gcgcccaccg ctcgcgcggg
     6601 gccgtccgta cggccagccg gaaaccggaa tcccgccagg cggtccgctc cgcgccggtc
     6661 agctcccacc acgccagctg ggccgcgtgc ccggcctggg ccatcgcctt gccggcggac
     6721 atctccagat ccgggttcag ccacagcacc gcgatcccgt ccggcgccgg agcgaccggc
     6781 tccgggtcgt cgaggtcggt ccccgagacc tggagcttgg ccagttcctt cggccacccg
     6841 tcgagcggga ccggcgggaa cacccgtacc tccgccgcgt caccgtgcac cgtgacaccc
     6901 ggcagggtct cggccttgcg ccactccgcg ccgcgcgccc gccggaccac cttgcggatc
     6961 cgcgcgtcct gccagtcgcg gaccgccccg gcccattcgc cctcgccgag cgcccgctcg
     7021 tcgctcagca gcaccagcac cgcgcgggcc gccgtctcca gcgcgtcggt acgggccggg
     7081 ggttcggcct tctcgatccg gacgaccagg gggagcacga actgcggtgc ctcgtcgcgg
     7141 gcggaccgct gcggccgcgg cgggtgctcc gcgcccgcgg cgggtaccgg ggtgctgtcg
     7201 tcgtggtgcg tgtccgggct gctcatcgcg ctgttcatcc cctgctcatg ccgctgttca
     7261 tcctcgcaaa ggatgccagc ctcccccttc aggatgatgc cgagggggtt cgggccgggc
     7321 gaggatcgaa cccatgaaga gtgatctttt cgcgtccgag cacctcgccc agccgtctgc
     7381 cgccccgggc atgaccctgc agaacgccaa gtccgtgaag tacaccgtca acggtgaaat
     7441 gctggcccgt cagggctcga tggtcgcctt ccgcggcaac ctccagttcg agcgcaaggg
     7501 ccagggcata ggcggcatgc tcaagcgcgc cgtcaccggc gagggcctgg cgctgatgtc
     7561 cgtacgcggg cagggcgacg cgtggttcgc gcaccaggcc ggcaactgct tcatcatcga
     7621 cttcgagccc ggcgacgccc tgaccatcaa cggccgcaac gtgctctgct tcgacccgac
     7681 cctgtcctac gagataaaga tggtgaaggg cgccggcatg accggcgggg gcctcttcaa
     7741 cagcgtcttc accggcaccg gcaagctcgc cgtggtctgc gacggccacc cgatcatcat
     7801 cccggtcacc gcccagaacc cggtctacgt ggacacggac gcggtcgtcg gctggagcgc
     7861 ccagctggag acgggcctgc accgctcgca gtccgtcggc tcgatgatcc gcggcggctc
     7921 gggcgaggcc gtccagctga tgctgcgcgg cgagggcttc gtcatcgtcc gcccgagcga
     7981 gctgacggaa accgcggccg cgcactgaac aggaccccac cgaagacgac ggccgtgcga
     8041 cgggacgcca tgcgactgga cgccgtggga cgccgctacg gcgtgcgggg accctgggtg
     8101 ctgcgcgggg tctcgctgga gctgccgccc ggcgcgctcg tccgcgtcga aggacgcaac
     8161 ggcggcggca agtccacgct gctgcggctc gtggccggca tcgacacccc gacccaggga
     8221 agcatcaccg gccgcccgcg ccgcaccgct tacgtacccg agcgcttccc ggccgtcctg
     8281 ccgctcaccg cgcaggccta cctcggccac ctgggccggg tccacgggct gacgcgcgcc
     8341 gaggccgcgc gccgggcggc gcagtggctg gagcggttcg gcgcggccgg gcacgcccgc
     8401 accccgctgg ccgaactgtc caaggggacc agccagaagg tggccgtcgc ccaggccctg
     8461 ctcgccggac cggggctgct cgtcctcgac gaggcgtgga ccgggctcga cgtgcccgcg
     8521 cgcgccgagc tggaccgggc cgtggccgag cggaccgccg ccgggggcac ggtgctgttc
     8581 gtggaccacg acccggcgcg gctcgccggg gcacccgacc gccactaccg ggtcgagggg
     8641 ggcgcgttgg aacccgtgcg gccgggcgcc gggcccgggc cccgcgtgcg gatcgaggcc
     8701 gccggaccgc ccggcgccgt cccgcccccc ggcctggcgg ccgagcccct gcccgccggc
     8761 ggattccgcc tgaccgtgcc cgccggccgg tccgacgcgg tgctgcgcga actgctcacc
     8821 gcacaccctg cctggcacat ccggaacgtg agtgacctgc cgtgaccgct ctgctgcgct
     8881 atcagagcgc gctgttgctg cgctcgcagc gctggctcgc gccggtgctg ctgtacgccg
     8941 ccttcctcgc cgtcgggttc cgccccgggg atcccgtacc ggactcgctg ggctactcgg
     9001 ccgccgcgct ggtcccggtg acggcctggc tggtgcggat ctgcctctcg gtcgaacccg
     9061 acgcggcgcg ggactgcgcg gccgccgcgg cgggcccggt acgggtgcac gcggcggccc
     9121 tgctcaccgg gctgggctgg ggcgccggcg cggggagcct cggcgccgtc gcggtgctgc
     9181 tgctcggcgc ccgcgagggg ccgcggctcc cggccgccgc cctggcgggg gccgcgtcgg
     9241 tgctggtgtg cgcgctgacg ggcgcggccg tgggcgcgct gtgcgcccgg ccgctgctga
     9301 gggcccccgg gtacgcggtc gcggcggcgg gcctcggcag cctgctggcc ctggtcacgg
     9361 cgggctcgcc ggcccgggtg gcggtcagcg ggctggtggg gggctcggtg gcgctcccgc
     9421 tgggagcgct ggcgggcgcg gcggcgctgg cctgcgcggc gggcgcggcc gcctgcctgg
     9481 ccgccgcgcg gcgggggtga gtacgctcgg ggcatggacc agtccgagcc gaccgagtcg
     9541 tactgccccg cgccggcggc gcccgcccgc gtcgtggcgg gaccgccgta cgcggactgc
     9601 ctggagtgcg gcaagcccac cgagtacggg gtccggaccc ccggcgtggt gctgtgcccg
     9661 gtctgcgagt ggcaggaagc ccagcgcacc gcctgctcgg gctagggcct gatcccaaag
     9721 acaggcccta ggtgcccatg agctcggaga ccttcacgaa gcggtagccg cgcttgcgca
     9781 actccgggac gatcgtgcgg atggcctcct cggtgacggg cgccgcgctg cgggtgcagt
     9841 gcatgaccac cagcgagccc ggcttcaccc cggccaggac ctgctcggcc accgcgtccg
     9901 ggtccttcgc gaaggcgtcc ccactgacca cgtcccactg caccgccgtg accttggccg
     9961 tggacagggc ccgcagcgcc tggtcgtcgt agcagccgcc ggggaagcgg aagtacggga
    10021 cggtgttgac ggcgcccgcc ttgcggaagg cgtcgaaggc ccggtccacg tcggcccggg
    10081 cggcggctcc gtcgagcgtg gggagtccgt agcaggggga cttgaaggcg tggtggctgt
    10141 acgagtggtt ggcgatctcg aagttcgggt cggtgccgat ggctttggcc tggtccgggt
    10201 actcctcggc ccagcggccc gtcatgaaga ccgtcgaggg caccttgagc gcccgcagcg
    10261 tgtcgatcag ctgggggttg tcgaagtgct ccccgcccgc cgcgcgcggt ccctgatcgg
    10321 aggtcatgtc cgcgtcgaag gtcagggcga cggtcttctc ggtcttctgc ctggcccgct
    10381 cgaagaccgg ggtcaggccg cccgggccgg gggccagcgt cggggccttg ccgggggcgc
    10441 cggccctcgg gagcgcggag gccgctccgg cggcgggggc gggtgcggag gcccgggccg
    10501 acgcggaggc ggaggccgag ggggtggcgg acgcgccgag ccgggcctgg ccggcgcctc
    10561 cgttcgaggg accggcgccg cccccgcagc cggcgaggac ggcgccgagg gcgccactga
    10621 ggacggccgc ggccgccgct ttgcgcaggg aagaggtcac ctacgcaaaa tatatgacta
    10681 tgtggcaatc agacgggcac ggcactcctc cacgtcgaac ccggcctccg ggtaccgcgg
    10741 accgatgagc tccaggtgct cccgcagcag agtggcgacg gcccagtcgc ggtaccactt
    10801 gcggtccgcg gggacgacga accacggcgc ggcgtccgtg gagcaccgct ccagcgccag
    10861 ctcgtaggcc tcctggtacg cgggccacag cgcccgctcg tcgatgtcgg acggggcgaa
    10921 cttccagtgc ttggacgggt cgtccagcct tcgcaggagc cgctcgcgct gcttctcgtg
    10981 gctgatgtgg aggaagactt tcaccacggt caccccgtcc cgcgcgaggg actcctcgaa
    11041 ccggttgatc tgcgcgtagc ggtggttcac ctcgctgcgg gacaccagtt cgcggacccg
    11101 ggcgatcagt acgtcctcgt agtgcgagcg gtcgaagacg ccgatctcgc ccggcttcgg
    11161 gagggcgcgg gcgatccgcc acaggaaggg gtgcgaccgc tcctcgtccg tgggcgcctt
    11221 gaaggccctg atccggcagc ccgcggggtt gagcgggccg gtcacgcgct tgaccgcgcc
    11281 gcccttgccg ctggtgtcca tgccctggag gacgaggagc acccggcggc ggtcgcccgc
    11341 ggtgctcgcg gcgaag
//
