LOCUS       NZ_CP011664            25464 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 chromosome 1, complete sequence.
ACCESSION   NZ_CP011664
VERSION     NZ_CP011664.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5105223
            Orig. end                         :: 5130687
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011664.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25464
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="14"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25464
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25464
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15464](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15464)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    72..87
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    603..620
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     gene            849..2468
                     /locus_tag="M444_RS22335"
                     /old_locus_tag="M444_22320"
     CDS             849..2468
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266317.1"
                     /locus_tag="M444_RS22335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22320"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_008737265.1"
                     /transl_table=11
                     /translation="MRGATSAKWVAGAVVVAMAATACSTSKDNAGEGGGNITVQLGEPQ
                     HGLVGQNTAESEGAEVLHALFTGLVNYDNKTNEPKLAVAESIETTDSKTWTIKIKDGYT
                     FHNGEKVDAQSFVRAWNWGANQDNAAEGLPFFAKIDGSDELAPGKDKKPTAKELKGLKV
                     VDEKTFTVTLKESFSQFKTMLGYNAFYPLPKAFEADPKKFGEAPIGNGAFQMDGVWDHN
                     KQIKVKRYDKYPAEGRAKLSGVTFKIYDNLDTAYNDLRADNIQILDKLPISAMATVSQE
                     FGDRYIYKPESGVGYLGLPLEQNPETFGKLEIRQAISMAIDRDAIGKSIFNGTRKPADD
                     FISPIVPGYRKGALGEFGTYNPAKAKEIFEKAGGIPGNKMELGYNADGGHKEWIEAVAN
                     QLKQNLGIEVTAKPYAKFGDMLDDLGASKYKGAFRMAWSMDYPAAENYLRPIFSKVAIE
                     NGSNYGHYKNDEFEAVMKQADEAKDPAEGLKLYQKADDMIIHDLPYIPVFTYMSSSAYS
                     KSVKNVEVDAQGRMDLANVELN"
     gene            2563..3507
                     /locus_tag="M444_RS22340"
                     /old_locus_tag="M444_22325"
     CDS             2563..3507
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550237.1"
                     /locus_tag="M444_RS22340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22325"
                     /product="ABC transporter permease"
                     /protein_id="WP_008737263.1"
                     /transl_table=11
                     /translation="MGRYLIRRLVQAIPVLLGATFLIYVLTFWLPGDPIQAMAGEKKAD
                     PLVAAMLREKYHLNDPFLAQYWNYISNVFQGDFGETFNGRKVLDLITDAFPYTMNLAIV
                     AFIIEAGVGVTAGVMAALRRGKFLDQLVLLSTLMVISIPVFVTGFVLQLSLGVQLKNSW
                     GIDFFAVSFNESDGLRAYILPAFVLASASLAYVARLTRTSLMETMRSDYVRTATAKGLP
                     RRRVVVNHALRNALIPIITFLGADLGSLMGGAVITERIFNIHGIGGLIAQSIHLQQGTV
                     LVGVVTLLVLVYVVANLAVDLLYAVLDPRIRYA"
     gene            3500..4456
                     /locus_tag="M444_RS22345"
                     /old_locus_tag="M444_22330"
     CDS             3500..4456
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266319.1"
                     /locus_tag="M444_RS22345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22330"
                     /product="ABC transporter permease"
                     /protein_id="WP_008737261.1"
                     /transl_table=11
                     /translation="MRDTTTAGDKMADTQTASAPPTGAPGARTEKKERVASLWSDALSD
                     LRRNPVFLVGAFLVVCLLVLSVVPQWFTDASPFGSSATCKLQDSLRPPSGDHWFGFDVQ
                     GCDVYTRTVWATRNSVIVGIVTTSLVVVVGGVLGLIAGWIGGFVDSILSRFTEIFFAIP
                     LLLGGMLIMSGLGTGNAWTVSVVMATLGWPQIFRIMRSSVLQNKNNDYVMAARALGAGS
                     LRITMRHILPNAVAPVIVVGAISLGVYIGAEASLSYLGIGVQPPEISWGLMVSDASVRW
                     LQAPHVLLFPAAALSITVLAFIMVGDAVRDALDPKLR"
     gene            4470..5525
                     /locus_tag="M444_RS22350"
                     /old_locus_tag="M444_22335"
     CDS             4470..5525
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006142147.1"
                     /locus_tag="M444_RS22350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22335"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_008737259.1"
                     /transl_table=11
                     /translation="MTIIDKTSNVPAPRSAPEGTPLLEVRDLHVEFHTRDGVAKAVNGV
                     SYSVSAGETLAVLGESGSGKSVTAQAIMGILDMPPGKIPHGEILFQGTDLLKLPTEEFR
                     KVRGSKIAMIFQDALSSLNPVHTVGAQLGEMFRVHRGMSKKDATAKAVELMDRVKIPAA
                     KARVGDYPHQFSGGMRQRIMIAMAMALEPDLIIADEPTTALDVTVQAQVMDLLAELQRE
                     MNMGLILITHDLGVVADVADKIAVMYGGRIVETAPVHEIYSRPAHPYTRGLLDSIPRLD
                     QKGQELYAIKGLPPNLLNIPSGCAFNPRCPKAQDVCRTDVPVLHSVTEQDGTEMPGRGS
                     ACHFWKEQLHG"
     gene            5518..6570
                     /locus_tag="M444_RS22355"
                     /old_locus_tag="M444_22340"
     CDS             5518..6570
                     /EC_number="7.4.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266321.1"
                     /locus_tag="M444_RS22355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22340"
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="WP_008737258.1"
                     /transl_table=11
                     /translation="MAELTKNATEREPILQVRNLVKHFPLTQGILFKKQVGAVKAVDGV
                     SFDLYRGETLGIVGESGCGKSTVAKLLMSLEKATAGEVFYKGQDITKLSGKALKAVRRN
                     IQMVFQDPYTSLNPRMTVGDIIGEPFDIHPEVAPKGDRRRKVQELLDVVGLNPEYINRY
                     PHQFSGGQRQRIGIARGLALNPEIIICDEPVSALDVSVQAQVINLMEKLQDEFDLSYVF
                     IAHDLSIVRHISDRVGVMYLGKMAEIGSDAEIYEHPTHPYTQALLSAVPVPDPGAREGR
                     ERIILTGDVPSPANPPSGCRFRTRCWKAQEKCSVEEPLLAIPERFKGLDTLAAHESACH
                     FAEEKAVLAV"
     gene            6698..7618
                     /locus_tag="M444_RS22360"
                     /old_locus_tag="M444_22345"
     CDS             6698..7618
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266322.1"
                     /locus_tag="M444_RS22360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22345"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_037790886.1"
                     /transl_table=11
                     /translation="MTDMLTVRPAGPGDASDICALLNAVDVIEIGRPETDLGTVKADLH
                     HPGVDLARDSWLAFRAGRLVAYALVWADAGPGRVDGDHYVLPGDPEAAVRLLELMEVRA
                     RVMAAVASETRLRIHLNVKPTLDLSLLADRGYRTVRRHQVMTRALDPDTDLPPAPPTGV
                     TLRDCANDEVDRRRAHALIEDSFAAHFGHVVRGYESWLDHIGALDWSLVWIASLPVQGD
                     VAVLLTRDDRTRMGWLSHIGVRADVRGRGIGGFLLRHGFAAYAARGRRSVGLSVDTLNE
                     TGALGLYEAHGMALHYAVDTWELAG"
     gene            complement(7585..8217)
                     /locus_tag="M444_RS22365"
                     /old_locus_tag="M444_22350"
     CDS             complement(7585..8217)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012792.4"
                     /locus_tag="M444_RS22365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22350"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_008737254.1"
                     /transl_table=11
                     /translation="MEPVTLTSERLAFRPLEPRDAPVIAGAWRDPAIRRWTTVPEPGTE
                     DQAMAFVSRTCASGWADDTNYIFGTYVRETGELIGVIGVFGLSWVCRSENLASMGAWAV
                     PGQRGLGYTVEAVRRVARWVFEDLRMDRVESVIEVGNDASLAVVRKAGFVLEGTLRSRV
                     IQHGTRRDAWLTSLLPQDAGVAPQLPYSEGRMSPPAAHPASSQVSTA"
     gene            complement(8205..10004)
                     /locus_tag="M444_RS22370"
                     /old_locus_tag="M444_22355"
     CDS             complement(8205..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891139.1"
                     /locus_tag="M444_RS22370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22355"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_008737252.1"
                     /transl_table=11
                     /translation="MSPRKRNTEPAAQEHVPAGQLLELFRPYRKQAALILLTILADAVA
                     SAAWPFLLRGIIDTALPQNRVRLLTMLALGILTICVLTNVLDVVRGSLATRTGQAVMHK
                     VRTRVYDRLQGMSLGFFTRTGVGDVQSRVVNDVGGMQATVTSTATSVVTNATGVVAVLA
                     GMLLLDWKLTSFSLPLLVAFVWVSRRVGQERRMVTGERQEQLAVVGGTVTDFLSVGGIL
                     LGRTMGRREQLLDAFAAESRRLGALETRTALAGRWRMSSIGMVMGAMPVLLYWAAGVLY
                     GLGGGAPSIGTLVAFVTLQQALAWPATQLMSAGVQIQSSLAVFQRIFAYLDLEEEIPES
                     GAPVTLSAPRGEVRFESVGFRYADGLDPALRDVTLSVPAGSSVALVGPTGAGKTTLGYL
                     VPRLYDVSAGRVTIDGVDVRDLSVRSLSRAVGVVSQEPYFFNASVADNLRFARPSSTDA
                     EIEEAARAAQIHDFVMSLPDGYATRVGERGHRFSGGERQRLAIARVLLRDPAVLVLDEA
                     TSALDTKTEAAVQRALEALSAGRTTLTIAHRLGTVRNADLIAVLDNGRVIESGTHEELL
                     ARGGRYAELVDYDNKEAEKTWSR"
     gene            complement(10001..10990)
                     /locus_tag="M444_RS22375"
                     /old_locus_tag="M444_22360"
     CDS             complement(10001..10990)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="M444_RS22375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22360"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_158512310.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.3e-11, bitscore:
                     40.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLTPEPPTPAEPVPGTDGLTLPQFLRCTADRYSPPHTPADPRLA
                     RLGDVFIAAGLAALHRAAAGPSWSEFRLRPVGADRGELYARIVRLGREALDTGEIDAFF
                     FVHKAPGLRLRFRTGPNATAEPDHLAAPSVWQDQGCVASWSAAVYEPEEHLFGGPVSMD
                     SVHRIFTADSLLWAEQHASAVRTGPPWALSLLMTRALFEELGVSGWEDREIWDLLRRRA
                     HRRFAGEPPLSWQRTAESLGRLWADPERLRSLLDPQCLEALGEYRAAVRHACAHWQETY
                     FQRPGARVGPREAAAFLVVHHWNRARLPMERQIAVTEALSGPENLAVL"
     gene            complement(11005..12339)
                     /locus_tag="M444_RS22380"
                     /old_locus_tag="M444_22365"
     CDS             complement(11005..12339)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="M444_RS22380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22365"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_008737247.1"
                     /sec_met_domain="LANC_like (E-value: 1.7e-42, bitscore:
                     144.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTTLPPAPLHHDAARRVADTIAGRLADAGAVAAATGVPGVFTS
                     SELHWSPPSLGRGHAGISLLFSSRVTRDPVNAALAHGHLARSEALRQEADRTEVGLYGD
                     VCGLSFAMECARRATGGYGRALASLDPQVAAQADGWCELVRREPRGTMSRYDVISGLSG
                     FGRSLLLRGGTCRDSLTRVLETLVAMARSIGDPETATPPGLWADGPPSSDGRGSASVRE
                     HGHLNLGIAHGITGPLALLALAHREGVVVKGQREAAEQLISVLGRFEENDAYGPFWPGI
                     VSREEWFAGRVEGIHRPRPSWCYGTPGVARALQLAGESFGWPDQVERARRAVAALAGTP
                     LSGCGLAESGLCHGLAGTLHMLGYFTEPSPEPGVICGMRDDLAAAIVARFRPEYAFGYR
                     VEMLNSPVGGDFPGFLEGAAGIALALDAYADGGASSLWDAALLAT"
     gene            complement(12336..15464)
                     /locus_tag="M444_RS22385"
                     /old_locus_tag="M444_22370"
     CDS             complement(12336..15464)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="M444_RS22385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22370"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_008737244.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.9e-153,
                     bitscore: 508.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.8e-15,
                     bitscore: 54.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.3e-27, bitscore:
                     93.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVNYFQATEPILLRISSLTPDGLRSSPPRSGDGELPDSEQLIS
                     YIQEMMKDDFFREAVAVSSVSLASALAKVERRAVMSRKNLLSTAVSLTRYFLRITGRPT
                     PFGLHAGVAEVRTGDRARAVFTGTARKAVRLDAGWLAGAADSWLALPAVRRAVDVVAND
                     LCTVRGDRLVLPYVTASPVDGTPATGRELSLRHTTLTAWIRDRARTTLRYGDLLADAVK
                     VFPTAGEERLDGVLLSLVRSEVLLTSLSPRLIDEKFLARTMSVLGPSSDEAAGLRDVLS
                     ALVDYRSAPPGDGAGAWTALEDAGRAVHPDGRSVAQVDLRSPAEVELPRAVLAEAEAYA
                     GALWRIAPEGKSHRRMRAYYEAFVEKYGEGAAVRLPDLIDPHRGLGYPGGYLNPRVSND
                     PRLYVHERALEGERPGDRLERIAALIQRGVVNPDRELVLSDEDIARITIDSRPSALPHS
                     LDLCFQLLADSAEGIDAGDFRLLASPMVGAGLAGATAARFAYVSRTEEAVARLVDPAGA
                     DDAITAQVVFRPQIPRLLNVVQVPELTRYDIPVGAFPAGNGNRHIDWRTLFVESDGERL
                     RLLLPDSGREVRPVVPHMLSMSSVAPNLARFLGELRFTGERKVWQPWDWAGYGLSPWQP
                     RVRIGKVVASPLTWRPSPEMRHLTNQRDDWSRAVDHWRREVRVDDEVTVVSGDKAYGID
                     LRDAFHREVLRRDLAREDLVLTETPRALGFGHGWSAGRSNEICIPLVAHPPRPPRAPHV
                     PVAAKTICVPERHPVGSLWTSIHIHAVLEAHDALVRGLGDLTAQVTDTVDRWFYLRYFS
                     PEPHVRLRLRSPDAASAAVVRQIVLEHLHRARETGLLREFSAQAYEPETTRYGGPRALD
                     AAEEVFCRDSRTAVAQLTLLGSGRSPVPLHLMMCAGHAMLLESLGDWDWRGWAARQFPK
                     CTDGSVTRGDVEAAARLIQPGRTAANLAAACGIPGIETLWREPSGLGRELGLSGDAGHR
                     ADRRRDTALVSLLHMQHNRLIGNDLASESRAIVLLGHVARQQLGRALNGKTQS"
     aSDomain        complement(14712..14990)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M444_RS22385_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="2.30E-17"
                     /identifier="RREFam001.1"
                     /label="M444_RS22385"
                     /locus_tag="M444_RS22385"
                     /protein_end="251"
                     /protein_start="158"
                     /score="54.4"
                     /tool="antismash"
                     /translation="VVANDLCTVRGDRLVLPYVTASPVDGTPATGRELSLRHTTLTAWI
                     RDRARTTLRYGDLLADAVKVFPTAGEERLDGVLLSLVRSEVLLTSLSP"
     misc_feature    complement(15336..15338)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15441..15457)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.44"
                     /tool="antismash"
     gene            complement(15556..15750)
                     /locus_tag="M444_RS41660"
     CDS             complement(15556..15750)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS41660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_008737242.1"
                     /transl_table=11
                     /translation="MTSAILLSTPTMDLSDFDLEIQTVLTGDPNTPITPVARFTSVTCE
                     PANTTNNFAQGNVQGPICC"
     misc_feature    complement(15764..15776)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     gene            16134..17768
                     /locus_tag="M444_RS22390"
                     /old_locus_tag="M444_22375"
     CDS             16134..17768
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1068:
                     extracellular solute-binding protein family 5"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015035952.1"
                     /locus_tag="M444_RS22390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22375"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_008737239.1"
                     /transl_table=11
                     /translation="MRGATHAKWAACAVAVALAATACGGGSDGGGGGGGGAGVVSSSWG
                     DPQNPLEPANTNEVQGGKVLDMLFRGLKRYDPKTGAALNMIADKIDTTDSQNFTITLKD
                     GWKFSNDEPVTAQSFVDAWNYGADVRNKQNNSPFFSDIVGYADVHPASGEPKAKTMSGL
                     VVKDPKTFTVALKNKFSTWPETLGYQAFSPLPKAFFTDHAGWLNKPVGNGPYLVDSYTK
                     GTGMKLRTWSGYPGPDKALNSGVDLKVYTDNNTAYTDLISGNLDLVDDVPAQQLKNVKN
                     DLGDRYINQPALIIQTLTFPLYDPQWSKEGMENVRRGISMAINRDEITKQIFRETRTPA
                     KDWTSPALGQKGGFSATLCGDACKYDPAAAKKLIQDAGGLPGGKVTLTSNVDTGSHRDW
                     MDAVCNSINNALGEGPVCTVNPVGTFADFRNQQSSFKLTGPFRSGWQADYPLIQNFLQP
                     LYYTGASSNYGKFSNPDFDKLVDEANQESDAAKAITKFQDAEKILVQQMPSIPLWYQNG
                     SAGYAERLTDVALNQFSVPVYNEIKVS"
     gene            17799..18722
                     /locus_tag="M444_RS22395"
                     /old_locus_tag="M444_22380"
     CDS             17799..18722
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018536294.1"
                     /locus_tag="M444_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22380"
                     /product="ABC transporter permease"
                     /protein_id="WP_008737237.1"
                     /transl_table=11
                     /translation="MGRYVIRRLLQMIPVFIGSTFLIFFMVYALGDPVAALFGDKAPDP
                     ATAARIRKDLYLDRPLWQQYLHYMGQIFQGDFGTAFNGQPVTELMASAFPVTLRLTLVA
                     IFFEIVIGITLGVISGLRRGKSVDTSVLVLTLVVISVPTFVTGYLLQYLFGVKWGWVRP
                     TVSPDAPLNELILPGIVLALVSLAYVTRLSRTSIAENVKADYVRTATAKGLPRHRVVTR
                     HLLRNSLIPVVTFIGTDIGALMGGAIVTERIFNIHGVGYQLYQGILRNNSPTVVGFVTI
                     LVIVFLVANLLVDLLYAVLDPRIRYA"
     gene            18715..19749
                     /locus_tag="M444_RS22400"
                     /old_locus_tag="M444_22385"
     CDS             18715..19749
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266325.1"
                     /locus_tag="M444_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22385"
                     /product="ABC transporter permease"
                     /protein_id="WP_008737235.1"
                     /transl_table=11
                     /translation="MPEPERPEPPERYEPPAYDPLEPGKGEAIAPTGQGGPIDLALDEA
                     ESLEKPLGDDPTGPGPREKARSLWSDAWHQLRRNPVFVIASLVIFFLVVISIWPQLIAS
                     GDPLQCELSKSQQGAEPGHPFGYDTQGCDVYTRTVYGARASITVGICATVGAALLGSAL
                     GGLAGFFGGWGDSLLSRVADIFFGIPVVLGGLVFLSVVTSTTVWPVVGFIVLLGWPQLA
                     RIARGSVITAKQNDYVQAARALGAGNGRMLLRHVAPNAVAPVIVVATIALGTYIALEAT
                     LSFLGVGLRPPTVSWGIDISNAASQIRNAPHMLLYPAGALSITVLAFIMLGDAVRDALD
                     PKLR"
     gene            19762..20736
                     /locus_tag="M444_RS22405"
                     /old_locus_tag="M444_22390"
     CDS             19762..20736
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266326.1"
                     /locus_tag="M444_RS22405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22390"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_037790884.1"
                     /transl_table=11
                     /translation="MLLEVRDLHVEFRTRDGVAKAVNGVNYSVAEGETLAVLGESGSGK
                     SVTAQAVMGILDTPPGRIAGGEILFKGKDLLKMKEDERRKIRGAGMAMIFQDALSSLNP
                     VLSVGAQLGEMYEVHRGMSRKAARAKAVELMERVRIPAARERVGDYPHQFSGGMRQRIM
                     IAMALALEPSLIIADEPTTALDVTVQAQVMDLLAELQRELNMGLILITHDLGVVADVAD
                     KIAVMYAGRIVESAPVHEIYAAPAHPYTRGLLDSIPRLDQKGQELYAIKGLPPNLLAIP
                     PGCAFNPRCPMARAACRAEVPPLAEVAPDRASACFFWKECVGA"
     gene            20729..21907
                     /locus_tag="M444_RS22410"
                     /old_locus_tag="M444_22395"
     CDS             20729..21907
                     /EC_number="7.4.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0015833 - peptide transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015611140.1"
                     /locus_tag="M444_RS22410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22395"
                     /product="dipeptide ABC transporter ATP-binding protein"
                     /protein_id="WP_008737229.1"
                     /transl_table=11
                     /translation="MPEPILEVRDLVKHYPLTQGILFRRQIGAVKAVDGVSFELRAGET
                     LGIVGESGCGKSTVAKMLVNLERPTAGSIAYKGEDITKLSGRALKAVRRNIQMVFQDPY
                     TSLNPRMTVGDIIGEPFDIHPEVAPKGDRRRKVQELLDVVGLNPEYINRYPHQFSGGQR
                     QRIGIARGLALRPEIIVADEPVSALDVSVQAQVVNLLARLQSEFRLSYVFIAHDLSIVR
                     HISDRVGVMYLGRVVEIGTDTQIYDHPTHPYTQALLSAVPVPDPLARAHRERIILTGDV
                     PSPANPPSGCPFRTRCWKAEERCAKEVPLLAVPEAFRPEGVADPAADRAVDPAAGRTAH
                     PAAHPSACHFAAEKRVVPGPGDLAAPPAPPPVRPDGPDVPGAPDVPGSPSKE"
     gene            complement(21927..22427)
                     /locus_tag="M444_RS43920"
                     /old_locus_tag="M444_22400"
     CDS             complement(21927..22427)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024273.4"
                     /locus_tag="M444_RS43920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22400"
                     /product="DinB family protein"
                     /protein_id="WP_008737227.1"
                     /transl_table=11
                     /translation="MSGWQGLALLMFRQVRAELTRMVDAGALGREPGPDANSAAWLVWH
                     VARGQDRNLSELAGLPQVYVEQGWAARFGRPADPSDTGYGHTPAEAAAFRGAGAPGAAV
                     LLGYLDAVHDRVEGYLAAAPAGDLARTAPSPTLGTAESVEARLAAQLADSLAHVGQLGL
                     LPD"
     misc_feature    complement(22482..22499)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.52"
                     /tool="antismash"
     gene            22761..22955
                     /locus_tag="M444_RS22420"
                     /old_locus_tag="M444_22405"
     CDS             22761..22955
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190440.1"
                     /locus_tag="M444_RS22420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22405"
                     /product="hypothetical protein"
                     /protein_id="WP_008737225.1"
                     /transl_table=11
                     /translation="MALSISAVVLLAIIVFLLVRRSGLKAGHACVCVLLGFYLASSSIA
                     PTLSQLTTNVAGMISGLKF"
     gene            23026..23922
                     /gene="mshB"
                     /locus_tag="M444_RS22425"
                     /old_locus_tag="M444_22410"
     CDS             23026..23922
                     /EC_number="3.5.1.103"
                     /GO_process="GO:0010125 - mycothiol biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mshB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266330.1"
                     /locus_tag="M444_RS22425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22410"
                     /product="N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-
                     D-glucopyranoside deacetylase"
                     /protein_id="WP_008737223.1"
                     /sec_met_domain="PIG-L (E-value: 1.2e-25, bitscore: 89.3,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGLPARRLLLVHAHPDDESINNGVTMAKYAAEGAHVALVTCTLG
                     EEGEVIPAALAHLTADREDALGAHRVGELAAAMAELGVTDHRFLGGPGRFRDSGMMGTE
                     QNRRPGAFWSADVDEAAAYLVEVIRELRPQVLVTYDPDGGYGHPDHIQAHRVAVRAAEL
                     AEEASYRRDLGEPHRISKVYWNRVPRSVVEEGFAALRAAGGMAAFPQPATPEDVPGVIA
                     DRRVTTEIEGDEASVAAKAAAMRAHATQIVVDRPFFALSNNLAQPLFAREYYELVAGEP
                     GAPAGERERDLFAGVTA"
     gene            23919..24317
                     /locus_tag="M444_RS22430"
                     /old_locus_tag="M444_22415"
     CDS             23919..24317
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007266331.1"
                     /locus_tag="M444_RS22430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_22415"
                     /product="DUF6113 family protein"
                     /protein_id="WP_008737221.1"
                     /transl_table=11
                     /translation="MTGPVAGGGLTPARIAACLGLLVAGAVVGAAGWLALDLWFPGGLL
                     LALAALLGLFLGGRIALGGGIGVGAAAAGWFLSYVLLSAPRSEGDFLLTSSGISLYAYL
                     LGGTVLAVICATVRGPYDRPVPAPRPRG"
     misc_feature    24746..24759
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
ORIGIN
        1 acgagccgtg gttcggccag ctggtgaccc gtaacaacgg ttcgctggtc gccgaccgcg
       61 ccggttcggt cacgccgttc gcgatgatca accttcagga gcgcggcgtc ctgttcaccg
      121 agcccggcac cgaggtgtac gagggcatga tcgtcggcga gaactcgcgc tccgacgaca
      181 tggacgtgaa catcaccaag gagaagaagc tcaccaacat gcgtgcggct tccgcggaca
      241 acaccgagaa cgtggtgccg ccccgcaagc tctccctgga gcagtccctg gagttctgcc
      301 gcgacgacga gtgcgtcgag gtgaccccgg aggccgtccg catccgcaag gtcgtcctgg
      361 accagaagga gcgctcgcgc accgcgtcgc gcgccaagtc cggtaagtag taccggggtt
      421 ccccaggcgg cgcctgggga ccgcccgtag cccggctgac gaacagcccc tcccgtcaca
      481 agtgtgttga cgggaggggc tgttcgcgtt tgtcaagcgg attattgcgt tcaggtgtcc
      541 gcattccgac cgtgacactc cggaaggtga gctaaccgtc cgtttcgcac gtgtctgtct
      601 cctatccgtt tgtccggatt tcgggttttc gccatgcggt gatgttgtga aaacgagacc
      661 acttaagtgt ggtttacggt ctgggcgtcc ctgaggatgg ctccattgag ctcgggtcaa
      721 tgggtcacgc gctgtgggga gcgccgactc acgagcacac acgatgggac cggatttcgc
      781 tgtcaggggt gtcagcggga gccgggtcct tcacgtatcg acagtgactc ctgaggaggc
      841 aattacccat gcgcggagca acgagcgcca agtgggtcgc gggtgccgtc gtcgtggcga
      901 tggccgctac ggcttgcagc accagcaagg acaacgcagg cgagggtggc ggcaacatca
      961 ccgttcagct tggtgagccg cagcacggcc tggtcggtca gaacaccgcc gagtccgaag
     1021 gtgccgaggt cctccacgcg ctcttcaccg gtctggtcaa ctacgacaac aagaccaatg
     1081 agccgaagct cgcggtcgcc gagtccatcg agaccacgga ctcgaagacc tggacgatca
     1141 agatcaagga cggctacacc ttccacaacg gcgagaaggt cgacgcccag tcgttcgtcc
     1201 gcgcctggaa ctggggtgcc aaccaggaca acgccgccga gggcctgccg ttcttcgcga
     1261 agatcgacgg ttccgacgag ctggccccgg gcaaggacaa gaagcccacc gccaaggagc
     1321 tcaagggcct caaggtcgtt gacgagaaga ccttcaccgt cacgctgaag gagtccttct
     1381 cccagttcaa gacgatgctg ggctacaacg ccttctaccc gctgccgaag gccttcgagg
     1441 ccgacccgaa gaagttcggc gaggccccca tcggcaacgg tgccttccag atggacggcg
     1501 tctgggacca caacaagcag atcaaggtca agcggtacga caagtacccg gccgagggtc
     1561 gcgccaagct gtccggcgtc accttcaaga tctacgacaa cctggacacg gcgtacaacg
     1621 acctgcgcgc cgacaacatc cagatcctgg acaagctccc catctcggcg atggccaccg
     1681 tctcccagga gttcggcgac cgctacatct acaagcccga gtccggcgtc ggctacctcg
     1741 gcctgccgct cgagcagaac cccgagacct tcggcaagct cgagatccgc caggcgatct
     1801 cgatggccat cgaccgggac gccatcggca agagcatctt caacggcacc cgcaagccgg
     1861 ccgacgactt catcagcccg atcgtccccg gctaccgcaa gggcgcgctc ggcgagttcg
     1921 gcacgtacaa cccggccaag gcgaaggaga tcttcgagaa ggccggcggc atcccgggca
     1981 acaagatgga gctcggctac aacgccgacg gcggccacaa ggagtggatc gaggccgtcg
     2041 cgaaccagct gaagcagaac ctcggcatcg aggtcaccgc caagccgtac gccaagttcg
     2101 gcgacatgct ggacgacctg ggcgcctcga agtacaaggg cgcgttccgc atggcgtggt
     2161 ccatggacta cccggcggcc gagaactacc tccgtccgat cttctcgaag gtcgcgatcg
     2221 agaacggctc caactacggc cactacaaga acgacgagtt cgaggccgtc atgaagcagg
     2281 cggacgaggc gaaggacccc gcggagggtc tgaagctgta ccagaaggcc gatgacatga
     2341 tcatccacga ccttccgtat atccccgtct tcacctacat gtcttcttcg gcctactcca
     2401 agtcggtgaa gaacgtcgag gtcgacgccc agggccgcat ggacctggcg aacgtcgaac
     2461 tcaactgaca cccctcttca ccaaggggat cgcgggggcg ggcaggcgga atcaggtttc
     2521 cgcccgcccg ccctttcccc ctgctcttcc gttggaggtc tgatgggccg ctacctcatc
     2581 cgccgactcg tacaggcgat ccctgtgctg ctcggtgcca cgttcttgat ctacgtattg
     2641 accttctggc tccccggcga cccgattcag gcaatggccg gagagaagaa ggccgatccg
     2701 ctcgtcgcgg cgatgctgcg tgagaagtac cacctcaacg accccttcct ggcgcagtac
     2761 tggaactaca tcagcaacgt gttccagggt gacttcggtg agactttcaa cggccgcaag
     2821 gtcttggacc tcatcaccga tgcgttcccc tacacaatga acctcgccat cgtcgccttc
     2881 atcatcgaag cgggcgttgg cgtgaccgca ggtgtcatgg cagctctccg ccggggcaag
     2941 ttccttgacc aactggtcct gctctccacc ctgatggtca tctccatccc ggtattcgtc
     3001 accggcttcg ttctgcagct ctcgctcggc gtccagctca agaacagttg gggaatcgac
     3061 ttcttcgctg tttccttcaa cgagtcggac ggcctccgcg cgtacattct tcccgccttc
     3121 gtactcgcct ccgcttcgct ggcgtacgtg gcgcgactga ctcgtaccag tctcatggag
     3181 acgatgcgat cggactacgt gcgcacggca acggcgaagg gcctccctcg ccgccgcgtc
     3241 gtcgtgaacc acgcactgcg caacgcgctg attccgatca tcaccttcct cggtgccgac
     3301 ctgggttccc tcatgggggg tgccgtcatc accgagcgca tcttcaacat ccacggcatc
     3361 ggcggcttga tcgcccagtc cattcacttg cagcagggca cggtcctggt gggagtcgtg
     3421 accctcctcg tcctcgtcta cgtcgttgcg aacctggctg tggaccttct gtacgccgtg
     3481 ctcgacccga ggattcgcta tgcgtgacac aaccacggcg ggtgacaaga tggccgacac
     3541 ccagaccgcc agcgcccccc cgaccggcgc gccgggcgca cggaccgaga agaaagagcg
     3601 ggtcgccagc ctctggtctg acgccctgtc cgacttgcgc cgcaacccgg tgttcctggt
     3661 cggcgcattc ctggtggtgt gcctgctcgt gctttccgtc gtgccgcagt ggttcaccga
     3721 cgccagcccg ttcgggtcca gcgccacatg caagttgcag gactccctca ggcctcccag
     3781 tggtgaccac tggttcggct tcgacgtcca gggctgcgac gtttacaccc gcacggtgtg
     3841 ggccacccgc aactccgtga tcgtcggcat cgtgaccaca agcctcgtcg tcgtggtcgg
     3901 tggcgtcctc ggtctgatag ccggctggat cggtggcttc gttgacagca ttttgtcccg
     3961 tttcaccgag atcttcttcg ccatcccgct gctcctcggc ggcatgctga tcatgtcggg
     4021 tctcggcacg ggcaacgcct ggaccgtttc ggttgtcatg gcgaccctcg gctggccgca
     4081 gatcttccgc atcatgaggt catcggttct ccagaacaag aacaacgact atgtgatggc
     4141 tgctcgcgca ctcggcgcgg gaagcctgcg catcacgatg cggcacatcc tgccgaacgc
     4201 cgtcgccccc gtcatcgtgg tcggcgccat cagcctcggt gtgtacatcg gggccgaggc
     4261 gtcactttcc tacttgggta tcggcgtcca gccgccagag atttcgtggg gcttgatggt
     4321 cagtgacgct tccgtccgct ggctgcaggc acctcacgtg ctccttttcc cggccgcagc
     4381 gctgagcatc accgtgctcg cgttcatcat ggtcggcgac gcggtgcgcg acgccctcga
     4441 cccgaagctg cgctgaggaa gggcgtacgt tgaccatcat cgacaagacc tcgaacgtcc
     4501 ccgcgccccg atcggcgccg gagggcaccc cccttctcga agtgcgcgac ctgcacgtcg
     4561 agttccacac ccgcgacggt gtcgccaagg ccgtgaacgg ggtctcgtac tccgtgagcg
     4621 cgggcgagac cctcgccgtc ctcggcgagt ccggttccgg caagtccgtg acggcgcagg
     4681 ccatcatggg catcctggac atgcccccgg gcaagatccc gcacggcgag atcctgttcc
     4741 agggcaccga cctgctcaag ctgccgaccg aggagttccg caaggtccgc ggttcgaaga
     4801 tcgccatgat cttccaggac gcgctgtcct cgctgaaccc ggtgcacacc gtcggcgccc
     4861 agctcggcga gatgttccgc gtccaccgcg ggatgtccaa gaaggacgcc acggccaagg
     4921 ccgtcgagct catggaccgc gtgaagatcc ccgccgccaa ggcgcgcgtg ggtgactacc
     4981 cgcaccagtt ctccggcggt atgcgccagc gcatcatgat cgccatggcg atggccctgg
     5041 agcccgacct gatcatcgcc gacgagccca ccacggctct cgacgtgacg gtccaggccc
     5101 aggtcatgga cctgctcgcg gagctccagc gcgagatgaa catgggcctc atcctgatca
     5161 cccacgacct cggcgtcgtc gccgacgtcg cggacaagat cgccgtcatg tacggcggcc
     5221 ggatcgtcga gaccgccccg gtccacgaga tctacagccg ccccgcgcac ccgtacacgc
     5281 gcggcctgct cgactcgatc ccgcgcctgg accagaaggg ccaggagctc tacgcgatca
     5341 agggcctgcc gcccaacctg ctgaacatcc cgagcggctg cgcgttcaac ccgcgctgcc
     5401 cgaaggccca ggacgtctgc cgcaccgacg tgccggtcct gcactcggtc accgagcagg
     5461 acggcaccga gatgccgggc cgcggcagcg cgtgccactt ctggaaggag cagctccatg
     5521 gctgagctca ccaagaacgc caccgagcgc gagccgatcc tccaggtgcg caacctggtc
     5581 aagcacttcc cgctgaccca gggcatcctg ttcaagaagc aggtcggcgc ggtcaaggcc
     5641 gtcgacgggg tctccttcga cctctaccgc ggtgagaccc tcggcatcgt cggcgagtcc
     5701 ggctgtggca agtccaccgt cgccaagctg ctgatgagcc tggagaaggc caccgccggc
     5761 gaggtcttct acaagggcca ggacatcacc aagctgtccg gcaaggccct gaaggccgtc
     5821 cgccgcaaca tccagatggt gttccaggac ccgtacacct cgctgaaccc gcgcatgacg
     5881 gtcggcgaca tcatcggcga gcccttcgac atccatcccg aggtggcccc gaagggcgac
     5941 cggcgccgca aggtccagga gctcctggac gtcgtgggcc tgaacccgga gtacatcaac
     6001 cggtacccgc accagttctc cggcggccag cgccagcgca tcggcatcgc ccgcggcctc
     6061 gcgctcaacc cggagatcat catctgcgac gagccggtct ccgcgctcga cgtgtcggtg
     6121 caggcccagg tcatcaacct gatggagaag ctccaggacg agttcgacct gtcctacgtc
     6181 ttcatcgcgc acgacctctc gatcgtccgg cacatctcgg accgcgtggg cgtcatgtac
     6241 ctcgggaaga tggccgagat cggctccgac gccgagatct acgagcaccc gacgcacccc
     6301 tacacccagg cgctgctgtc ggccgtcccg gtcccggacc cgggcgcccg cgagggccgc
     6361 gagcggatca tcctcaccgg tgacgtcccc tcgcctgcca acccgccgtc gggctgccgc
     6421 ttccgcaccc gctgctggaa ggcccaggag aagtgctccg tcgaggagcc gctgctggcg
     6481 atcccggagc gcttcaaggg cctggacacc ctggccgcgc acgagtcggc gtgccacttc
     6541 gcggaggaga aggccgtcct ggccgtctga tctcccgcgg gacgcacgtc ttgtcagggc
     6601 gcccggtacc ggatcgttcc ggtaccgggc gccctgacgc gtgggcgggc acggaaaccg
     6661 gttgccttcg gggcccgccg ccaccgacag tgggccgatg accgacatgc tgaccgtccg
     6721 ccccgccggg cccggggacg cgtccgacat ctgcgctctg ctcaacgccg tcgacgtcat
     6781 cgagatcggc agaccggaaa cggacctcgg cacggtcaag gccgacctgc accaccccgg
     6841 cgtcgacctg gccagggact cctggctcgc cttccgggcc ggccggctcg tcgcctacgc
     6901 gctggtctgg gccgacgccg ggcccgggcg ggtcgacggc gaccactacg tgctgcccgg
     6961 cgaccccgag gccgccgtac ggctcctgga gctgatggag gtccgggccc gggtcatggc
     7021 cgccgtcgcc tccgagaccc gcctgcgcat ccacctcaac gtgaaaccca ccctcgacct
     7081 ctccctgctt gccgaccgtg gctaccgcac cgtccgccgc caccaggtga tgacgcgagc
     7141 cctcgaccct gacacggacc tgccccccgc cccgcccacc ggggtcaccc tgcgcgactg
     7201 cgcgaacgac gaggtcgacc ggcgccgggc ccacgccttg atcgaggaca gcttcgccgc
     7261 tcacttcgga cacgtggtac gcgggtacga atcctggctg gaccacatcg gcgcccttga
     7321 ctggtccctg gtctggatcg cctccctgcc cgtccaaggc gacgttgccg tgctcctcac
     7381 ccgcgacgac cgcacccgca tgggctggct cagccacatc ggcgtccgcg cggacgtccg
     7441 cggccggggc atcggcggat tcctcctgcg tcacggcttc gccgcctacg cggcccgagg
     7501 tcgccggtcg gtgggactga gcgtggacac cctcaatgaa accggtgcgc tcggactcta
     7561 cgaggcgcac ggtatggccc tgcactacgc ggttgacacc tgggagctcg cagggtgagc
     7621 ggcggggggg ctcatccgcc cctcactgta ggggagctgc ggtgccaccc cggcgtcctg
     7681 cggcagcagg gacgtcagcc aggcgtccct gcgggtcccg tgctggatga cgcgcgaacg
     7741 caaggtgccc tccaggacga agcccgcctt gcgcacgacg gccagcgagg cgtcgttgcc
     7801 aacctcgatg acgctctcta cccgatccat ccgcaggtcc tcgaacaccc agcgcgccac
     7861 ccggcggacg gcttccacgg tgtagcccag ccctcgttgg ccgggaaccg cccaggcgcc
     7921 catggacgcg aggttctcgg agcggcagac ccaactgagc ccgaacacgc cgattacgcc
     7981 gatgagttcg ccagtttccc ggacatacgt cccgaagatg tagttggtgt cgtcggccca
     8041 gccggatgca cacgtacggg agacgaatgc catggcctgg tcctcggtac ccggctccgg
     8101 caccgtagtc caccggcgga tcgccggatc ccgccaggca cccgcgatca ccggggcgtc
     8161 cctcggctcc agcggcctga acgccagccg ctcgctggtc aaggtcaccg gctccatgtc
     8221 ttctccgctt ccttgttgtc gtagtcgacc agttcggcgt accggccgcc gcgtgccagg
     8281 agttcctcgt gcgtgccgct ctcgatcacg cggccgttgt ccaacaccgc gatcaggtcc
     8341 gcattccgca cggttcccag gcggtgcgcg atggtgagcg tcgtccggcc ggccgacagt
     8401 gcctccagcg ctcgctggac ggccgcctcg gtcttcgtat cgagggcgct cgtcgcttcg
     8461 tcgaggacca gcaccgccgg atcgcgcagc agcacgcgag cgatggccag ccgctgccgt
     8521 tccccgccgg agaacctgtg gccacgctct ccgacccggg tcgcgtaccc gtcgggcaac
     8581 gacatcacga agtcgtggat ctgtgccgcg cgggccgctt cctcgatctc ggcgtcggtc
     8641 gaggacggac gggcgaagcg caggttgtcc gccacggacg cgttgaagaa gtacggttcc
     8701 tgcgacacca cacccaccgc tcgggacagc gaccggacgg agaggtcccg gacgtcgacc
     8761 ccgtcgatgg tcacccggcc tgcggacacg tcgtagagcc gcggcaccag gtacccgagc
     8821 gtggtcttcc ccgcccccgt cgggcccacc agtgccacgc tactgcccgc tggcacggac
     8881 agggtgacgt cccgcagcgc cgggtccaga ccatcggcgt agcggaagcc gacggactcg
     8941 aaacgaacct cgccgcgcgg cgcggatagc gtcaccggcg ccccagactc ggggatctcc
     9001 tcctccaggt ccaggtaggc gaagatgcgc tggaacactg ccaaggagga ctggatctgc
     9061 acaccggcac tcatcagctg ggtggcgggc caggccagtg cctgctggag ggtcacgaac
     9121 gcgacaagcg tcccgatgga cggcgcgccg ccgcccagcc cgtacagcac ccccgccgcc
     9181 cagtacagga gtaccggcat cgcccccatc accataccga tggaggacat ccgccagcgg
     9241 ccggccagcg ccgtgcgggt ttccagcgct ccgagccgcc gggactcggc ggcgaaggcg
     9301 tccaacaatt gctcccggcg ccccatggtg cggccgagca gaattccgcc cacggacagg
     9361 aagtcggtga ccgtgccacc cactaccgcg agctgttcct gccgttcgcc ggtgaccatc
     9421 cggcgctctt ggcccacccg tcggctgacc cacacgaagg ccacgagaag ggggagggag
     9481 aagctcgtca gcttccagtc caacagcagc atcccggcca agaccgccac gacgccggtt
     9541 gcgttcgtga cgacggaggt agcggtggag gtcaccgtcg cctgcatccc gcccacgtcg
     9601 ttgaccaccc gggactggac gtcaccgacc ccggtgcggg tgaagaagcc gagtgacatg
     9661 ccctggagcc tgtcgtagac ccgggtccgc accttgtgca tgacggcctg acccgtccgg
     9721 gtcgccaggg aaccgcggac cacgtccagg acgttcgtca gcacgcaaat cgtgaggatg
     9781 cccagcgcca gcatcgtgag gagcctcacc cggttctgcg gcagggcggt gtcgatgatg
     9841 ccacgcagca ggaacggcca agcggcggag gccacggcgt ccgcgaggat ggtcagcagg
     9901 atcagcgccg cctgtttgcg atacggacgg aacagctcca gcagctgtcc cgccgggacg
     9961 tgttcctgcg cggccggctc cgtgttccgc ttgcgggggc tcacagcacc gccaggttct
    10021 cggggcccga cagggcctca gtgacggcga tctgacgttc catgggcagg cgtgcccggt
    10081 tccagtggtg gacgacgagg aaggcggctg cctcccgcgg gccgacgcgg gcaccggggc
    10141 gctggaagta cgtctcctgc cagtgggcgc acgcgtggcg cacggccgcg cggtactcgc
    10201 cgagcgcctc caggcactgc ggatccagca gcgaacgcag acgctccggg tccgcccaca
    10261 agcggcccag gctctcggcg gtccgctgcc aggacagcgg cggctcccca gcgaaccggc
    10321 ggtgtgcccg tcggcgcaac aggtcccaga tctcgcggtc ctcccagccg gacacaccca
    10381 gttcctcgaa gagggcgcgg gtcatcagca gggacagggc ccagggcggg ccggtgcgta
    10441 cggccgaggc gtgctgctcg gcccacagga gggagtcggc ggtgaagatc cggtgcacgc
    10501 tgtccatcga gaccggcccg ccaaacaggt gctcctcggg ctcgtagacg gctgcggacc
    10561 agctcgcgac acagccttgg tcctgccata cgctgggcgc cgccagatgg tcgggttccg
    10621 ccgttgcgtt cggtcccgtc cggaatcgca ggcgcaggcc tggggccttg tgaacaaaga
    10681 agaaggcgtc gatctccccg gtgtccagcg cctcgcggcc aaggcggact atccgcgcgt
    10741 acagctcccc gcggtccgcg ccgacagggc ggagcctgaa ctccgaccag ctcggcccgg
    10801 ctgccgcccg gtgcagcgca gccaggcctg ctgcgatgaa cacgtctccg aggcgtgcga
    10861 gccgcgggtc ggcgggggtg tgtggagggc tgtaccggtc ggccgtacag cgcagaaact
    10921 gaggcagggt gaggccgtcg gttccgggca ccggttcggc gggagtggga ggttcgggag
    10981 taagggtcat ggcggctccc ccgctcatgt cgccagcagg gcggcgtccc agagggaact
    11041 cgcaccgccg tccgcgtagg cgtccagtgc cagggcgatg ccggccgcgc cctccaggaa
    11101 cccggggaag tcgccgccca cgggggagtt gagcatctcc acccgatagc cgaaggcgta
    11161 ctccgggcgg aagcgggcga cgatcgccgc ggccagatcg tcgcgcatgc cgcagatgac
    11221 gccgggctcg ggcgagggtt cggtgaagta ccccaacatg tgcagggtgc ccgccaggcc
    11281 gtggcacaag ccggactcgg cgagtccgca gccggagagc ggtgtacccg ccagggcggc
    11341 cacggcccgg cgagcccttt ccacctggtc cggccagccg aagctctccc ctgccagctg
    11401 gagcgcgcgg gccacgccgg gggtcccgta gcaccaggaa gggcgggggc ggtgaatgcc
    11461 ctccacccga ccggcgaacc actcctccct cgaaacgatt ccgggccaga agggcccgta
    11521 cgcgtcgttt tcctcgaatc gtccgagcac cgagatcagc tgctcggcgg cctcgcgttg
    11581 tcctttcacc acgacgcctt cccggtgagc gagggccaac agagcgagcg gaccggtgat
    11641 tccgtgggcg atcccgaggt tcaagtggcc gtgctcccgg acggaggcag agccgcgccc
    11701 gtcgctggag ggcggcccgt cggcccacag ccccggcggc gttgccgtct ccgggtctcc
    11761 gatggatcgg gccatcgcca ccagcgtttc gaggactcgg gtgagagagt cacggcaggt
    11821 gccgccccga agcagcaggc tccggccgaa accggacagc ccgctgataa cgtcgtaccg
    11881 gctcatggtg ccccggggct cccggcgtac cagctcgcac cagccgtccg cctgagccgc
    11941 cacctgtggg tccagggatg cgagggccct gccgtagccg cccgtggctc ggcgtgcgca
    12001 ctccatcgcg aaggagagac cgcagacgtc cccgtacagg ccgacttccg tcctgtcggc
    12061 ctcctgccga agagcctcag aacgggcgag gtgtccgtgg gcgagtgcgg cattgacggg
    12121 atcccgcgtg acgcgagagc tgaacaacaa cgagattccc gcgtggcccc ggcccaggga
    12181 aggcgggctc cagtgcagtt ccgaggaggt gaacacgcca ggcacgcctg tggccgcagc
    12241 gacggccccg gcgtcggcga gccgtccggc gatcgtgtcc gcgacgcgcc gcgcggcgtc
    12301 gtggtgcagt ggcgccggag gcagggtcgt cggtgtcatg actgcgtctt cccgttcagg
    12361 gcccggccga gttgctgccg tgccacgtgt cctagcagca cgattgcccg ggattcgctc
    12421 gccaggtcgt tgccgatcag ccggttgtgc tgcatgtgga gaagactgac cagtgctgtg
    12481 tcgcgtctgc ggtcggcccg gtggccggca tcgccggaca gccccaactc gcggccgagc
    12541 ccgctcggtt cccgccagag cgtctcgatc ccggggatcc cgcaggcggc cgccaggttc
    12601 gcggcggtcc ggcccggttg gatcaaccgg gccgctgcct cgacgtcgcc ccgcgtcacg
    12661 gagccatccg tgcacttcgg gaactggcga gcggcccagc cccgccagtc ccagtcgccg
    12721 agcgactcca gcagcatcgc gtgcccggcg cacatcatca ggtggagggg gaccgggctg
    12781 cggccggaac cgagcagggt gagctgcgcg acggccgtcc ggctgtcccg gcagaaaacc
    12841 tcctctgccg cgtccagagc ccgcggtccg ccgtaccgcg ttgtttccgg ctcgtatgcc
    12901 tgcgcgctga actctcggag cagcccggtc tcccgtgcgc ggtgcaggtg ttccaggacg
    12961 atctggcgca cgactgcggc cgaggccgcg tccggcgagc gcagccgcag gcgcacatgc
    13021 ggctccgggg agaagtagcg caggtagaac cagcggtcga cggtatcggt gacctgcgcg
    13081 gtcaggtcgc cgagtccacg cacgagggcg tcgtgggcct ccaggacggc gtggatgtgg
    13141 atgctggtcc acaggctgcc gaccgggtgc cgctccggca cacagatcgt cttcgcagcc
    13201 acgggcacgt gcggcgcgcg gggcggccgg ggcgggtggg cgaccagggg tatgcagatc
    13261 tcgttgctcc gtccggccga ccagccgtgc ccgaacccca gggcccgcgg tgtctcggta
    13321 aggacgaggt cctcgcgcgc gaggtcgcgg cgcaagacct cacggtggaa cgcgtcgcgc
    13381 aggtcgatgc cgtatgcctt gtcgccgctg acgaccgtga cctcatcgtc tacccgcacc
    13441 tcccggcgcc agtggtcgac ggcccgactc cagtcgtctc tctggttcgt caggtggcgc
    13501 atctccgggc tcggccgcca ggtcagcggc gaagcgacga cctttccgat ccggaccctg
    13561 ggctgccagg gcgagaggcc gtagccggcc cagtcccagg gctgccaaac cttgcgctca
    13621 ccggtgaatc ggagctcgcc gaggaaccgg gcgaggttgg gggcgacaga cgacatggag
    13681 agcatgtgcg gcacgacggg acgcacttcg cggccggagt ccggcaggag caggcgcagg
    13741 cgttcgccgt cggattccac aaagagggtt ctccagtcga tgtgcctgtt gccgttgccg
    13801 gccgggaagg cgccgacagg tatgtcgtac cgggtgagct ctggcacctg cacgacgttg
    13861 agcagccgtg ggatctgggg ccggaagacg acctgagcag tgatcgcgtc atcggccccg
    13921 gccggatcca cgagccgggc gacggcctcc tcggtcctgc tgacgtaggc gaaacgcgcc
    13981 gccgtggccc ccgcgagacc cgcgccgacc atgggcgagg ccaacagccg gaagtcgccc
    14041 gcgtcgatgc cctcggcgct gtcggcgagg agttggaagc acaggtccag ggagtgtggc
    14101 agcgcactgg ggcgtgagtc gatggtgatc cgggcgatgt cttcgtcaga gaggacgagt
    14161 tcacggtcag ggttgacaac gccccgctga ataagggcgg cgatccgctc cagccggtcg
    14221 cccggtctct cgccctccag cgcccgctcg tggacgtaca gtcggggatc gttgctcacc
    14281 cgggggttga ggtagccgcc ggggtacccg aggccacgat gcggatcgat caggtctggc
    14341 agccggacgg cggcgccttc cccgtatttc tcgacaaagg cctcgtagta cgcgcgcatc
    14401 cggcggtgcg acttgccctc gggggcgatc cgccaaaggg cgccggcgta cgcctcggcc
    14461 tccgcgagaa cggcccgggg cagttcgacc tcggccggag accgcaggtc cacctgcgcg
    14521 acggaccggc cgtcggggtg gacagcccgc ccggcgtcct ccaaggccgt ccacgctccg
    14581 gcgccgtcgc cgggtggagc cgagcggtag tcgaccagag cggacagtac gtcgcgcagg
    14641 ccggcggcct cgtcggagga ggggccgagc acggacatcg tgcgagccag gaacttctcg
    14701 tcgatcagac ggggagagag cgaagtcagg aggacctcgc tgcggaccag ggacagcaga
    14761 accccgtcca gccgctcctc gcccgctgtg gggaagacct tgacagcatc cgcgagtaga
    14821 tccccatatc tcagggttgt ccgtgcgcgg tcgcgtatcc aggccgtcag ggtggtgtgg
    14881 cgcaaggaga gttcccggcc cgtggccggg gtgccgtcca ccggggaggc cgtcacgtag
    14941 ggcaggacga gtcggtcccc gcggacagtg cacaggtcgt tggccacgac gtcgacggct
    15001 cgccgtaccg caggcagggc gagccaggag tctgcggcgc cggccagcca gcccgcgtca
    15061 aggcggaccg cctttcgcgc ggtaccggtg aacacggccc gcgcccggtc acccgtccgc
    15121 acctcggcca cgcccgcgtg cagtccgaac ggcgtggggc gccccgtgat gcgcaggaag
    15181 tagcgggtga gagagacggc cgtgctcaga aggttcttcc ggctcatcac cgcacggcgt
    15241 tccactttgg cgagcgccga agccaatgag acgctggaca cggcgacggc ttcccgaaaa
    15301 aaatcgtcct tcatcatttc ctggatgtag gaaattaatt gctcactgtc ggggagttcg
    15361 ccgtctccgg atcggggagg gctggagcgg agtccgtccg gcgtgagcga tgaaatcctg
    15421 aggagtatcg gttcggtggc ctggaagtaa tttacggatg tcatatggag agcactttct
    15481 gagcgctgag ggccgccgcg ccaaggatgg gcgcggcggc cccttagcgg agctccgtgc
    15541 tccgcaggcc ggcgactaac agcagatcgg gccctgtacg ttgccctgcg cgaagttgtt
    15601 ggtcgtgttg gcgggctcgc aggtgaccga ggtgaatcgg gccacggggg tgatcggggt
    15661 gttcgggtcg ccggtgagga ccgtctgaat ttcgaggtcg aaatcagaga ggtccatcgt
    15721 cggagtcgag agaagtattg cagaggtcat tctgggctcc tcattccgaa ttgcaagggc
    15781 cgttgttcgg ccttttgtga tcctaggttg gcgtttctcg gggtgtcaag ggattgaaat
    15841 cttgtcgcct tttcaattgg aatgaaagag aaattgacca actctaatgc atgaaagggt
    15901 gtggtaggtg gtggctgagg gagcttgagg tggaatggct cattcgcccc gcttggggtg
    15961 accttctgac tgattctcgg tggtgtgccg cgttcgggtc cgccacgctg tcactcccac
    16021 gggtggcagc cgcgtgacgc gagggtgcaa tcggtccaac cggaggtgta tgggacccct
    16081 catagggtga cattggcccc taagtgagac ttgggacccc taggaggcac tccatgcgcg
    16141 gagccaccca cgccaagtgg gccgcatgtg cggtggccgt cgccctcgcg gcgacggcct
    16201 gcggcggcgg tagcgacggc ggcggaggcg gtggcggcgg cgcgggggtc gtcagctcct
    16261 cgtggggtga cccgcagaac ccgctggagc cggccaacac caacgaggtg cagggcggca
    16321 aggtcctcga catgctcttc cggggcctga agcggtacga cccgaagacc ggcgcggccc
    16381 tcaacatgat cgccgacaag atcgacacga cggacagtca gaacttcacc atcacgctga
    16441 aggacgggtg gaagttcagc aacgacgagc cggtcacagc ccagtccttc gtggacgcct
    16501 ggaactacgg cgccgacgtg cgcaacaagc agaacaactc cccgttcttc tccgacatcg
    16561 tcggctacgc ggacgtacac cccgcctccg gtgagcccaa ggccaagacg atgtccggac
    16621 tggtcgtcaa ggaccccaag accttcacgg tcgccctgaa gaacaagttc tccacctggc
    16681 ccgagaccct cggctaccag gccttctccc cgctgcccaa ggccttcttc accgaccacg
    16741 ccggctggct gaacaagccg gtcggcaacg gcccgtacct ggtggactcg tacaccaagg
    16801 gcaccggcat gaagctgcgc acctggagcg gctacccggg ccccgacaag gcgctgaaca
    16861 gcggagtcga cctcaaggtc tacaccgaca acaacaccgc ctacacggac ctgatctccg
    16921 ggaacctcga cctcgtcgac gacgttcccg cgcagcagct caagaacgtc aagaacgacc
    16981 tcggcgaccg gtacatcaac cagccggccc tgatcatcca gaccctcacc ttcccgctgt
    17041 acgacccgca gtggagcaag gagggcatgg agaacgtccg ccgcggcatc tccatggcga
    17101 tcaaccgcga cgagatcacc aagcagatct tccgcgagac ccgcaccccc gccaaggact
    17161 ggacctcccc ggccctcggc cagaagggcg gcttcagcgc cacgctctgc ggcgacgcct
    17221 gcaagtacga cccggccgcg gccaagaagc tcatccagga cgccggcggg ctccccggcg
    17281 gcaaggtcac gctgacctcc aacgtggaca ccggctcgca ccgcgactgg atggacgccg
    17341 tctgcaacag catcaacaac gcgctcgggg agggcccggt ctgcacggtc aacccggtcg
    17401 gcaccttcgc cgacttccgc aaccagcaga gctccttcaa gctgaccggc cccttccgct
    17461 ccggctggca ggccgactac ccgctgatcc agaacttcct ccagccgctc tactacaccg
    17521 gcgcctcctc caactacggg aagttcagca acccggactt cgacaagctc gtcgacgagg
    17581 ccaaccagga gagcgacgcg gccaaggcca tcaccaagtt ccaggacgcc gagaagatcc
    17641 tcgtccagca gatgccgtcc atcccgctct ggtaccagaa cggcagcgcc ggctacgccg
    17701 aacgcctcac cgacgtggcg ctcaaccagt tcagcgtccc cgtctacaac gagatcaagg
    17761 tcagctgacc caccgtcgga tcgatcctgg agcagtccat gggacgttat gtgatccggc
    17821 ggctgctcca gatgatcccg gtgttcatcg gcagcacgtt cctgatcttc ttcatggtgt
    17881 acgcgctcgg cgaccccgtc gcggccctct tcggcgacaa ggcgcccgac ccggccaccg
    17941 cggcgcgcat ccgcaaggac ctctacctcg accgccccct gtggcagcag tacctccact
    18001 acatgggcca gatcttccag ggcgacttcg gcaccgcctt caacggccag cccgtcaccg
    18061 agctgatggc ctccgccttc cccgtcaccc tgcgcctgac cctcgtcgcg atcttcttcg
    18121 agatcgtcat cggcatcacc ctcggcgtga tcagcggcct gcgccggggc aagtccgtcg
    18181 acacctccgt gctggtgctc accctcgtcg tcatctccgt gccgaccttc gtgacgggct
    18241 acctgctcca gtacctcttc ggcgtcaaat ggggctgggt gcgccccacc gtctccccgg
    18301 acgccccgct gaacgagctg atcctgcccg gcatcgtcct cgcgctggtc tcactcgcct
    18361 acgtcacccg gctgtcgcgc acctccatcg ccgagaacgt caaggccgac tacgtccgca
    18421 ccgccaccgc caagggcctg ccgcgccacc gggtcgtcac ccggcacctg ctgcgcaact
    18481 ccctcatccc ggtcgtcacc ttcatcggca ccgacatcgg cgcgctgatg ggcggcgcca
    18541 tcgtcaccga gcggatcttc aacatccacg gcgtcggcta ccagctctac cagggcatcc
    18601 tgcgcaacaa ctcgccgacg gtcgtcggct tcgtgaccat cctcgtcatc gtcttcctgg
    18661 tggcgaacct gctcgtcgac ctgctctacg cggtcctgga cccgaggatc cgttatgcct
    18721 gagccggagc ggccggagcc gcccgagcgc tacgagcccc ccgcctacga cccgctggag
    18781 cccggaaagg gagaagccat cgcgcccacc ggccagggag ggcccataga cctcgcgctg
    18841 gacgaggccg aaagcctcga aaagcccctg ggcgacgacc ccaccgggcc cgggccgcgg
    18901 gagaaggccc gctcgctgtg gtccgacgcc tggcaccagc tgcgccgcaa cccggtcttc
    18961 gtcatcgcct cgctggtgat cttcttcctc gtggtcatct ccatctggcc acagctcatc
    19021 gccagcggcg acccgctcca gtgcgagctg tccaagtccc agcagggcgc cgagcccggc
    19081 caccccttcg gctacgacac ccagggctgc gacgtctaca cccgcaccgt ctatggagcc
    19141 cgcgcctcca tcaccgtcgg catctgcgcc accgtcggcg cggccctgct cggctcggcc
    19201 ctcggcgggc tcgccgggtt cttcggcggc tggggcgact cgctgctctc ccgggtcgcc
    19261 gacatcttct tcggcatccc cgtcgtcctc ggcggcctcg tcttcctgtc cgtcgtcacc
    19321 agcaccaccg tctggccggt cgtcggcttc atcgtgctgc tcggctggcc gcagctcgcc
    19381 cgcatcgccc gcggctcggt catcaccgcc aaacagaacg actacgtcca ggccgcccgg
    19441 gccctcggcg ccgggaacgg ccggatgctg ctgcggcacg tggcccccaa cgcggtcgcg
    19501 cccgtcatcg tcgtcgccac catcgccctg ggcacgtaca tcgccctgga ggccacactg
    19561 tccttcctcg gcgtgggcct gcgcccgccc accgtctcct ggggcatcga catctccaac
    19621 gccgcctccc agatccgcaa cgccccgcac atgctgctct acccggccgg cgcgctgagc
    19681 atcaccgtgc tcgccttcat catgctcggc gacgcggtgc gcgacgccct cgaccccaag
    19741 ctgcgctgag gagtgggcac catgctgctc gaagtccgcg acctccacgt ggagttccgt
    19801 acgcgggacg gggtcgccaa ggccgtcaac ggcgtcaact actcggtggc cgagggcgag
    19861 accctcgccg tgctcggcga gtccggctcg ggcaaatcgg tgaccgccca ggccgtgatg
    19921 ggcatcctcg acacgccgcc gggccggatc gcgggcggcg agatcctgtt caagggcaag
    19981 gacctcctga agatgaagga ggacgagcgc cgcaagatcc gcggcgccgg catggccatg
    20041 atcttccagg acgcgctgtc ctcgctgaac ccggtgctca gcgtgggcgc gcagctcggc
    20101 gagatgtacg aggtccaccg cgggatgtcc cgcaaggccg cccgggccaa ggccgtcgag
    20161 ctgatggagc gggtgaggat cccggcggcc agggaacgcg tgggggacta cccgcaccag
    20221 ttctcgggcg gcatgcgcca gcgcatcatg atcgccatgg cgctggccct ggaaccctcc
    20281 ctgatcatcg ccgacgagcc cacgaccgca ctggacgtca ccgtgcaggc ccaggtgatg
    20341 gacctgctcg ccgagctcca gcgcgagctg aacatgggcc tcatcctgat cacccacgac
    20401 ctcggggtcg tcgccgacgt cgccgacaag atcgccgtca tgtacgcggg ccggatcgtc
    20461 gagtcggcgc ccgtccacga gatctacgcc gcccccgccc acccgtacac gcgcggtctg
    20521 ctcgactcga tcccgcgcct ggaccagaag ggccaggagc tctacgcgat caagggcctg
    20581 ccgccgaacc tcctcgccat cccgcccggc tgcgccttca acccgcgctg cccgatggcc
    20641 cgggccgcct gccgggccga ggtgccgccg ctggcggagg tcgccccgga ccgcgccagc
    20701 gcgtgcttct tctggaagga gtgcgtcggt gcctgagccg atcctcgaag tgcgcgacct
    20761 cgtcaagcac tacccgctga cgcagggcat cctcttccgg aggcagatcg gcgcggtcaa
    20821 ggccgtcgac ggggtctcct tcgagctgcg ggccggtgag accctcggca tcgtcggcga
    20881 gtccggctgc ggaaagtcca ccgtcgccaa gatgctggtc aacctggaac gcccgaccgc
    20941 cggctcgatc gcgtacaagg gcgaggacat caccaagctg tccggccgcg cgctgaaggc
    21001 cgtccgccgc aacatccaga tggtgttcca ggacccgtac acctcgctga acccgcgcat
    21061 gacggtcggc gacatcatcg gcgagccctt cgacatccac cccgaggtgg cgcccaaggg
    21121 cgaccggcgc cgcaaggtcc aggagctgct cgacgtcgtc ggcctgaacc cggagtacat
    21181 caaccgctac ccgcaccagt tctccggcgg ccagcgccag cgcatcggca tcgcccgcgg
    21241 cctggccctt cggccggaga tcatcgttgc ggacgagccg gtgtccgcgc tggacgtctc
    21301 cgtccaggcc caggtggtca acctgctggc gcggctgcag agcgaattcc ggctgtccta
    21361 cgtgttcatc gcgcacgacc tctcgatcgt ccggcacatc tccgaccggg tgggcgtgat
    21421 gtacctcggc cgggtcgtgg agatcggcac cgacacccag atctacgacc accccaccca
    21481 cccgtacacc caggccctgc tctcggcggt gcccgtcccg gacccgctgg cccgcgccca
    21541 ccgcgaacgg atcatcctca ccggggacgt cccctcgccg gccaacccgc cgtcgggctg
    21601 ccccttccgc acccgttgct ggaaggcgga ggagcgctgc gcgaaggagg tcccgctgct
    21661 ggcggtcccg gaggcgttcc ggccggaggg ggtggcggat ccggcggcgg accgggcggt
    21721 ggacccggcg gccggccgga cggcccatcc ggcggcccac ccctcggcct gccacttcgc
    21781 cgccgagaag cgggtggtcc cggggccggg ggacctcgcg gcgccgcccg cgcccccgcc
    21841 ggtccggccg gacggccccg atgtgcccgg tgcccccgat gtgcccggtt cgccgtcgaa
    21901 ggagtagccg gggcccgcgc ccccggtcag tccggcagca ggcccagctg gcccacgtgg
    21961 gccagggagt ccgccagctg ggcggccagc cgggcttcca cggactcggc agtgccgagc
    22021 gtcgggctcg gggcggtccg ggccaggtcc ccggccgggg ccgccgccag gtagccctcc
    22081 acccggtcgt gtacggcgtc caggtagccc agcagcaccg ccgcgccggg ggcgcccgcg
    22141 ccccggaagg cggccgcctc ggcgggcgtg tgcccgtagc cggtgtccga ggggtccgcc
    22201 gggcggccga aacgcgccgc ccagccctgc tccacgtaca cctgggggag cccggcgagc
    22261 tcggacaggt tccggtcctg gccgcgcgcg acgtgccaga cgagccaggc ggcgctgttc
    22321 gcgtccggcc cgggctcccg gccgagcgcc ccggcatcga ccatccgggt gagttccgcc
    22381 cgtacctgtc ggaacatcag cagcgccagc ccctgccaac cgctcatttc tcgccacctc
    22441 cgaaaaccgc tgtgaaccct gccgtcacca ccgtaactcg gtttacacgg tggcaacttg
    22501 accgtttctg tcccgagatc tggcccgtgc agcctggctg acgtgcggcc gtgcgggtgc
    22561 cgacagccgg ccgggaggtg aacgagcccc ccggccggcc tttccgtgct cctgaacatg
    22621 cgcggcatgc gcccctcgtg ctgccggatt tcgatcgatg cgctggtacg gaaagttatg
    22681 atcggtagcg cacggtgggt atgagtccgc cgagcacgag tacgcgtacc gatgtccgct
    22741 cgacgtggag gtgaaacgcc gtggcactat cgatctctgc cgtggtgctg ctggcgatca
    22801 tcgtcttcct gctggtgcgc aggtcggggc tgaaggccgg gcacgcgtgc gtctgcgtgc
    22861 tgctcggctt ctatctggcg agctcttcga tcgcccccac cctcagccag ctgaccacga
    22921 acgtggccgg catgatcagc ggcctcaagt tctaggcggt cgcccggtcg ggccggcccg
    22981 cggccggtcc ggcggcgccg gggggacacc ctctacgctg accccatgaa cggtcttccc
    23041 gcccgtcgtc tgctcctcgt gcacgcgcac ccggacgacg agtcgatcaa caacggcgtc
    23101 accatggcca agtacgccgc cgagggtgcc cacgtcgcgc tggtgacctg caccctcggc
    23161 gaggagggcg aggtcatccc ggccgcgctc gcccacctga cggccgaccg cgaggacgcc
    23221 ctcggtgccc accgggtcgg cgagctcgcc gccgccatgg ccgaactcgg cgtcaccgac
    23281 caccggttcc tcggcggccc cggccgcttc cgcgactccg ggatgatggg caccgagcag
    23341 aaccgccgcc ccggggcctt ctggtccgcc gacgtggacg aggccgccgc gtacctcgtg
    23401 gaggtgatcc gggagctgcg cccgcaggtg ctcgtcacct acgacccgga cggcgggtac
    23461 gggcaccccg accacatcca ggcccaccgc gtcgccgtcc gcgccgccga gctggccgag
    23521 gaggcgtcgt accggcgcga cctcggcgag ccgcaccgga tctcgaaggt ctactggaac
    23581 cgggtgccgc gctcggtggt cgaggagggc ttcgccgcgc tgcgggccgc cggcggcatg
    23641 gcggccttcc cgcagccggc cacgcccgag gacgtgccgg gggtgatcgc cgaccggcgg
    23701 gtcaccaccg agatcgaggg tgacgaggcg tcggtggcgg cgaaggcggc cgcgatgcgg
    23761 gcgcacgcca cgcagatcgt cgtggaccgg cccttcttcg ccctgtcgaa caacctggcg
    23821 cagccgctgt tcgcccgcga gtactacgag ttggtggcgg gcgagccggg cgctccggcc
    23881 ggcgagcgcg agcgcgacct gttcgccggg gtgacggcgt gacgggcccg gtggccggcg
    23941 gcgggctgac gccggcccgg atcgcggcct gcctcggcct gttggtcgcc ggggccgtgg
    24001 tcggcgcggc cggctggctc gcgctggacc tctggttccc gggtgggctg ctgctggccc
    24061 tggcggccct cctcgggctc ttcctcgggg gccggatcgc cctcggcggc ggcatcgggg
    24121 tgggcgcggc ggcggcgggc tggttcctgt cctacgtcct gctcagcgcc ccgcgctccg
    24181 aaggggactt cctgctcact tcgtccggaa tcagcctgta cgcatacctt ttgggcggga
    24241 cggtgctggc tgtgatctgt gccacggtgc gcggcccgta cgaccggccc gttccggctc
    24301 cgcggccgcg gggctgacaa gtcgtcggtc tccgttcccg gacgggtacc ggctggttga
    24361 cgacgggtcg gcgcggctcg gacgccgctg tcgcgggcgt gcgcgggggg cttgcggggg
    24421 gtcaagagga atccctgatt ccctggcgtc aattgcgcgc gggcgacggc cagtatggtg
    24481 gacgggccgc cgagctgccc gcgcacggta tgacgggcgg cggagccaac cgggagaacc
    24541 tgccttgagt cgtgaaactg acagttcgtc ctccgggccc caagggcgcg gtggagccgc
    24601 ttacccctcg ggtacgccgc cgtatggaac cggccagtat ccgtccacgg acgctgcggc
    24661 gaccaccccg gaggagaacc ctgtgacgtc gaagccgtcc acgcccgaca ccgacgggcc
    24721 gaagaccgag accaccctga cgacccggat ccggatcaac atcccgggtt cgcggccgat
    24781 cccaccggtc gtggtgcgca agccggtcgc cgacgccgag gccggcgccg aggccgcccc
    24841 ggcgcccgcg cgcgagccga agccgaacgg gcggccgcgg ccgacccggg tcgaggcggc
    24901 gcccgagccc ggcgacgggc cggtgcgcgc cgcgctgccg ccgtcttcct ccgcgcccgc
    24961 cgggggacgg ccgccggctc ccgcgcaggg gcaggccccc gcgccggctc cggccgagcc
    25021 cgccgagccc gccagcaact ggttcgcccc gcgcaaggcg gcccccgccc cgcccgcggc
    25081 cctgccgacc cggcagcccg gcgcgagcgc cggctacccg aacccggcgg gacagcggcc
    25141 cggcaatccc ggcggccccg gcaaccccgg cggccccggc ggccccggca acccgggcag
    25201 ccccggaaac ccgggcgctc ccgccgcggg cggccgcccg gcgggctacc cctccgcgcc
    25261 cgccccggcg ggccagggcc cgggcgcgcc cggccccgat gcccgtacgg ccgggcccgg
    25321 cgcgcccgcg ggtcccggat tcgacggacg ccccgacggc ggctacggcc gccagcccgg
    25381 cgggaacggt tttcccccgg ccggcgcggg cccgcggccc ggcgcccccg gcgcgggcta
    25441 cgcccaggcg cccaccgcac ccac
//
