LOCUS       NZ_CP011664            24564 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 chromosome 1, complete sequence.
ACCESSION   NZ_CP011664
VERSION     NZ_CP011664.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4292764
            Orig. end                         :: 4317328
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011664.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24564
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24564
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24564
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14564](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14564)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(316..1488)
                     /locus_tag="M444_RS18475"
                     /old_locus_tag="M444_18455"
     CDS             complement(316..1488)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886446.1"
                     /locus_tag="M444_RS18475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18455"
                     /product="transposase"
                     /protein_id="WP_235441268.1"
                     /transl_table=11
                     /translation="MEMQLVYEEQVGHRVPDDALGRLCAEIFAPLPRSDQRRKGELYLR
                     GLLSAGGRKSMRNIATHVGDRAAEQSLHHFISSSTWDWGPVRATLARYLERSLRPRAWV
                     VHPVVIPKAGRHSVGVARRFVPSLGQVVNSQEAFGVWAANEETSSPVNWRLMLCEDWRD
                     TDRLGPAPLPQDAHLAATPLECVTGALAEVRTWTGGGSPRPVVVDLPDISPTALARSLG
                     VARLPYLASVRGTTAVAPATPAVLGNDSRPTSAHQLLRMIRTLRRPVTWSDPGGLASRT
                     SLVAGVQVRLPGVQRPLLLLGEWTGTNGWPRQCWITDMTDVPWGALLRLAKLTHRVETD
                     FAEVATRVGIVDFEGRSFGGWHRHTTLASAAHALSSEYRDQRPQPMAWPA"
     misc_feature    complement(1451..1465)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            1936..3444
                     /locus_tag="M444_RS18480"
                     /old_locus_tag="M444_18460"
     CDS             1936..3444
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (91-473). E-value:
                     1.8e-22. Score: 72.1. Matches aSDomain:
                     nrpspksdomains_M444_RS18480_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019992528.1"
                     /locus_tag="M444_RS18480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18460"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_037797912.1"
                     /sec_met_domain="PF00561 (E-value: 4.3e-25, bitscore: 87.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTYRRKAALLALSVVSVATALTGAGAPLARAAPGAPASSLEWKP
                     CARPGGPAAQECAELPVPLDYADPDGPRITLAVSRLRSDRPDARRGTLLVIPGGPGGSG
                     VQRLSQKGNALSRELAGAYDIVALDPRGVGGSTKASCGLDPADRWLVTLRSWAGPDGET
                     AGNAARARRIADACAREGGPVLRSFTTANEVRDTDRFRQALGERKLSAWGVSYGTYVGA
                     VYAQTYPHRTDRWVLDSSGDPDPRRLARGWLANMSQGADDRFPDFAAWAADPARDAEGL
                     RLAEHPEQVEPLLLELAARLDREPKESDVAGTPLTGNGLRQALQNALYGDALFPGLARL
                     VRAAQDPAARPTLPPELARPLPDTDAAVMVGVICNDVRWPQGAAGYEEAVAADRAAHPL
                     TAGMPVNVTPCSFWKDRPREEPTRITDRGPSNILMIQNLRDPSTPYFGALKMRRALGDR
                     ARLVTVDHGGHGVYLAGTSTCGDRAVTHYLTTGTRPHQDTYCAP"
     aSDomain        2209..3354
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_M444_RS18480_Abhydrolase_1.1"
                     /evalue="1.80E-22"
                     /label="M444_RS18480_Abhydrolase_1.1"
                     /locus_tag="M444_RS18480"
                     /protein_end="473"
                     /protein_start="91"
                     /score="72.1"
                     /tool="antismash"
                     /translation="TLLVIPGGPGGSGVQRLSQKGNALSRELAGAYDIVALDPRGVGGS
                     TKASCGLDPADRWLVTLRSWAGPDGETAGNAARARRIADACAREGGPVLRSFTTANEVR
                     DTDRFRQALGERKLSAWGVSYGTYVGAVYAQTYPHRTDRWVLDSSGDPDPRRLARGWLA
                     NMSQGADDRFPDFAAWAADPARDAEGLRLAEHPEQVEPLLLELAARLDREPKESDVAGT
                     PLTGNGLRQALQNALYGDALFPGLARLVRAAQDPAARPTLPPELARPLPDTDAAVMVGV
                     ICNDVRWPQGAAGYEEAVAADRAAHPLTAGMPVNVTPCSFWKDRPREEPTRITDRGPSN
                     ILMIQNLRDPSTPYFGALKMRRALGDRARLVTVDHGGHGVYL"
     misc_feature    3969..3983
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            4121..>4699
                     /locus_tag="M444_RS44130"
                     /pseudo=""
     CDS             4121..>4699
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="M444_RS44130"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAREMHDTVSYHLGLIAAQSGALWSTAPDDTVREDAETIRRHSAD
                     ALAELRDIVGVLRHAAGRGDEGDPARLANLGELVREARLDAVLDLDLGLPDGRGCGPEV
                     EQAAYRTVQEALTNVRKYAPGSRIDIRVGPSAAGDALLVEVRNGPVPDPPAGGAGGGFG
                     LTGLAERTALVGGTFRAGATADGGFAVRAE"
     gene            complement(4711..5478)
                     /locus_tag="M444_RS39940"
     CDS             complement(4711..5478)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980774.1"
                     /locus_tag="M444_RS39940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_073797827.1"
                     /transl_table=11
                     /translation="MTTTLGNALYDQKLASVYDRMYPIGHDTEQAVAFVAALTPPGGSV
                     LELGVGTGRIAVPLAGHGFTVHGIDGSEPMLAELRARDPQGTVTTRLGDFTREGTGRTF
                     DTVTLVLNTFFVAVTKEQQVGCLRLAREQLAPGGRFVLEAFDPAPYHHMEKPDHSMRHL
                     DERSIMLDTLTVDRSQQLMLSTHTIIDGGAPETREHLLRYAFPFEIDLLAELSGLRLVE
                     RTEDWAGTPYTSSSLRHVSVYEADPDSPWGDCR"
     gene            complement(5579..6406)
                     /locus_tag="M444_RS43110"
                     /old_locus_tag="M444_18470"
     CDS             complement(5579..6406)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980775.1"
                     /locus_tag="M444_RS43110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18470"
                     /product="response regulator transcription factor"
                     /protein_id="WP_053065784.1"
                     /transl_table=11
                     /translation="MIVDDEVLLRSCMQRILESEPDIDVPVACDGPAALGAIELHRPDV
                     VLLDLRMPEVDGFAVLAGLGALTDPPAVAILTTFLADEDIAAALGSGAKGFLLKDATPQ
                     ELVHAVRVLASGGTVLSPQAARIVVGGYLGTGPSYGGGPSYGGGPSYGGGPGYDELDPG
                     LTPVLDAGLDPGLDAGLEARLDSLTDRERQVLDLLAGGLTNADIGRRLLLSASTTKEHV
                     SAILAKLGLTNRVQAAVVATHRATHRTGHRTTYRAASPPGRPRPPALAGTGTR"
     misc_feature    complement(6524..6539)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.24"
                     /tool="antismash"
     gene            complement(6556..6957)
                     /locus_tag="M444_RS18495"
                     /old_locus_tag="M444_18475"
     CDS             complement(6556..6957)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS18495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_18475"
                     /product="hypothetical protein"
                     /protein_id="WP_037797913.1"
                     /transl_table=11
                     /translation="MLLLEFALHSLMDLTLWIGGKGLDRARCARRVAAFRRGEPVTLRC
                     RYRTGAAAGRASGMQPGKLTLGRSGAVLDGPGASALRLAGPAVAATGGGRGGTALTCTT
                     AQGEKAELLVLTWDSAMVALIEESIEAGA"
     gene            complement(7027..8070)
                     /locus_tag="M444_RS18500"
                     /old_locus_tag="M444_18480"
     CDS             complement(7027..8070)
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980837.1"
                     /locus_tag="M444_RS18500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18480"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_234008874.1"
                     /transl_table=11
                     /translation="MTPAPPVMTPLSLMYPLMASDLDELAAFGETVRDLALERLYLGQS
                     LVVDTHQAFAHLAGRGIRVPAGTSVALTALRHPLDAAVQARSVALLTGRPVVAGFGAGD
                     PDFVAALRGEPYESPLTAVAEYLSVVRRLLDGEAVEDFRGRYVRLDGGPLPLPHAAAAA
                     PCPRVSLGVGVLRPRMAHTAGQIADVAITLLTPAGHLREAIVPALARGAGSRGRPVPGV
                     TAIVPCAVRRPGRDPRKLAFAAHAPHLSGEHYAAMLRSAGLDVDVSDPWAGAGALVDGG
                     VFAYGTPEEVAAQLTGYGEAGATEIALSCAGVLLTEGPEAALADVRAIVEAVRDRAGRP
                     APVTRIP"
     gene            complement(8121..10004)
                     /locus_tag="M444_RS43910"
                     /old_locus_tag="M444_18485"
     CDS             complement(8121..10004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980836.1"
                     /locus_tag="M444_RS43910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18485"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_008741466.1"
                     /transl_table=11
                     /translation="MSAEQTQPQTQAHPQTHRRLSRDLRYWWLVLRSFRGLSPLRVSAL
                     ALLTLLTAAVPAAGIWLTADAVQAVADAVEGVPGAGDRLTRAAAGLVAVAVGEHVLSSV
                     AQYLNSLLQLEFGAAIGEQVMVKGTRMDLGSYEDPEAYDRLQRALRESGGGTAFEVFEE
                     MLRTLTSLASLVMVSSVLFSWNAWLAVVILLAPVPALAAHIVFSKEGYAVEYHRAQDRR
                     RAFYYQDLTTTDSSYKEVKLYQLGPYLVDRYRALVQEFFRVDRGLARRRHGWSAVLGLV
                     SVAGSAGALVFALKSTVSTGRLGELAGYLQALGAVHVAAGGLLLGVATLYQNTLFTGNL
                     FDYLSLPEGSVTCGTLPFPRRLTHGIEFQDVTFRYPGTETVALDRFSCFVPAGTCCALV
                     GANGAGKSTVVKLLTRLYEPTSGRILIDGVPIEEYDTTDLQRNIGVVFQDFIRYEMPVR
                     HNIGFGRVEELDDTDRIRAAAAASGADAFVDGFEGTYDTVLGRHFEGGRQLSGGQWQKI
                     ALARAFLRDAPIAILDEPTAAIDPEAEADIFGRLRTICSRATSLVVSHRFSTVRVADKI
                     LVLDGGSLIEEGTHGELLALGGTYARLFRLQADAYLTPSGAGPAERSGDLV"
     gene            complement(10001..13240)
                     /locus_tag="M444_RS18510"
                     /old_locus_tag="M444_18490"
     CDS             complement(10001..13240)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="M444_RS18510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18490"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_037797915.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.1e-152,
                     bitscore: 505.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.3e-13,
                     bitscore: 48.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.7e-33, bitscore:
                     114.5, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRYHALDFHLLRAPALPVGVWRDALDGADRERTRARLLRALADD
                     PRVRHGLVAAGSGLLDGLAKLDGSAPGSGSGSGSGKEARRVHSRALRYLTRMSTRPTPF
                     GAFSGVALGTFGDTTTARLGATALGEAHVRADTAWLLALVQRLEEDPQSLARLGVSVNA
                     MAHRVGDRLVLPSSGVHGDASDRRAVRVRHTAPLARIRALAPPAAPVPYATLVTELAEE
                     FPAAGRERISAFVTELVGLGLLVTDLRPPVTEPRPEAYVLDRLTAAGVDHPAVAALREI
                     VGLTGRAPYGDTDALRRLRAAQRALVPLHKGQPSQVDSALDLAAPDLNRQIAAEVAEAV
                     GCLAELGRAAPAGYDHLGAYHQAFMERYGSDALVPVLDLLGAERGLDAPGGYLTPPRAM
                     ALNQHVAEDDPHTARALVALAADAWRRGAGEVELTDEVLRRLLPPDAANATDSAGLSGR
                     PDCPGLDAYVQIAADGPEAIDRGEWRAVLNPDGLGEGGRTFGRFGHLLGADATDRLRAY
                     ARAREALEPDVVVAELAYLPANGRGANVAIRPAVHAYEIPVNVAPTAAPEQVIDLADIH
                     VGAADEGLRLYSARLGRELVVVQNHMLSPYGAPNVCRFLLEVSRARYATPAGFGWGPVE
                     GAPHLPRVVRGRVVVRAAEWNLYPAGAQAAPAAGGPVPVPRSADEVARWRRDWEVPRYV
                     YLADDDNRLLLDLDHPLCVDELLAELDGGAGSGSGRVTLHEALPGPDSAWLRDGSGRGH
                     LSEVVIPLIATGAGEGAREIPRESGSGLAPEEIRRKAAPSAHPAHLPGSAWSYLKLYAA
                     RDLHDEIAATELPALLPQLREAGADPDRWFYIRYADPDAHLRIRVRTATPAEAPGTALP
                     ALLAWGEGLVRRGLAERLEVATYHPEISRYGGPAVHDAVEELFAANSDVSCRLLRLLWD
                     EEEPGLEPEAVVIAAVDALYAQWGLGIRERLAAMPRPAQDAEARERYRKDRDYLCELLH
                     PWERRPHPLGRAHHGLLAAVLDAQAPAVRRAALAVARAEAAGTLWGGRDAILASLAHMQ
                     VNRLLPMDRPAENRCYLVWGHVLNCLRGRPQ"
     aSDomain        complement(12488..12766)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M444_RS18510_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="1.30E-15"
                     /identifier="RREFam001.1"
                     /label="M444_RS18510"
                     /locus_tag="M444_RS18510"
                     /protein_end="251"
                     /protein_start="158"
                     /score="48.8"
                     /tool="antismash"
                     /translation="VSVNAMAHRVGDRLVLPSSGVHGDASDRRAVRVRHTAPLARIRAL
                     APPAAPVPYATLVTELAEEFPAAGRERISAFVTELVGLGLLVTDLRPP"
     gene            complement(13314..14564)
                     /locus_tag="M444_RS18515"
                     /old_locus_tag="M444_18495"
     CDS             complement(13314..14564)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="M444_RS18515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18495"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_053065785.1"
                     /sec_met_domain="LANC_like (E-value: 8.5e-33, bitscore:
                     112.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVVPSLPAGLAARAEAVAGLIAERLDTPAHADAAAVRAARQSDV
                     SFWTGASLSEGHAGLALLHRHAAGREEGQGRARAFTRAAFAATGQSPLHHPGLFDGTAG
                     LAFALQDVSRDEPRFLPSLGRLHEQLARQVIDADWPRVPGAVADHHYDLVYGAAGIAVQ
                     LCAAAPATPLVEEALERCLRHLVWVAADGNWAVGGRLDTGMAHGAAGIAAALAAAWRRD
                     RRVPGQRAALDELTGWLLAVGDGGAGPGRGGSSGGAGGLRWSRVVPADGREAAPAWCHG
                     TGGVAAGLLAVARATGDPGLEARAFAALDGLLDRVAGGDVPRSPTVCHGLAGIAALAHE
                     FAAHGSAGAARALPGLALRLVDAADPGLPLLYRDHETTGHVVDNPGLLTGAAGIALTLR
                     ALATGHRPGWWSVLFPR"
     gene            complement(14719..14901)
                     /locus_tag="M444_RS18520"
                     /old_locus_tag="M444_18500"
     CDS             complement(14719..14901)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS18520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_18500"
                     /product="hypothetical protein"
                     /protein_id="WP_037793209.1"
                     /transl_table=11
                     /translation="MDEFHLDARVTVSADPAETQLSPAASIASRIVSKAVVKQTIKQTI
                     KMTAACAAVRTNGKC"
     misc_feature    complement(14977..14993)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.9"
                     /tool="antismash"
     gene            complement(15067..15651)
                     /locus_tag="M444_RS18525"
                     /old_locus_tag="M444_18505"
     CDS             complement(15067..15651)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015661353.1"
                     /locus_tag="M444_RS18525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18505"
                     /product="hypothetical protein"
                     /protein_id="WP_008741462.1"
                     /transl_table=11
                     /translation="MEHLNEYLMTQKITPLVNRYTVTTPDGGQVLAFAEQKRLALKEEL
                     TLWSGEDRTRRLGGFKARQVIDFGATYDVSRPDGATIGTFRKDVKASLIRSTWHLTQGD
                     EAAAIGKERRLGVALARRGWELLDFVVPVIPVPPVPFVYHFDFVREDKPVLSVERKWGI
                     RDRYVIRVQDPSLDRVLALCMAVALDALQSR"
     gene            complement(15759..16439)
                     /locus_tag="M444_RS18530"
                     /old_locus_tag="M444_18510"
     CDS             complement(15759..16439)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569320.1"
                     /locus_tag="M444_RS18530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18510"
                     /product="cytochrome b/b6 domain-containing protein"
                     /protein_id="WP_008741461.1"
                     /transl_table=11
                     /translation="MTSTPGSAGPTAAATPPPSEPGARVRRFSRAERWTHRTTAALVLL
                     CVATAAALYVPQVAELVGRRELVVTVHEWAGILLPAPFLLGLGSPAFRADLRRLNRFGP
                     HDRTWLRAARRRDRRRASRPAGKFNAAQKLYASWIAGAALVMLATGLLMWFTHLAPLVW
                     RTSATFVHDWLALAIGVVLAGHIGRALADPEARRGMRTGSVARSWAAREHPLWLDAGSG
                     RGDG"
     gene            complement(16381..17046)
                     /locus_tag="M444_RS18535"
                     /old_locus_tag="M444_18515"
     CDS             complement(16381..17046)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576522.1"
                     /locus_tag="M444_RS18535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18515"
                     /product="molybdopterin-dependent oxidoreductase"
                     /protein_id="WP_037793243.1"
                     /transl_table=11
                     /translation="MLGLGAGGLVAAPYVQRGTEALLGAASDKDPTGLTGLLPNGGGFR
                     YYSVASSVPRRPEGDYRLTVDGLVERPATYGLDALRALPQTRVVRDVQCVTGWRVPATA
                     FSGVRLSLLLDAAGVRPGARAIRFTCFDGAYSESLTLPQARRDDVLVCLRMRDEPVSHA
                     HGGPVRLYVAPMYFYKSAKWISGITVTSEVRPGYWEERGYDVDAWVGRSNGRGDAPTV"
     gene            complement(17173..18018)
                     /locus_tag="M444_RS18540"
                     /old_locus_tag="M444_18520"
     CDS             complement(17173..18018)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012415.4"
                     /locus_tag="M444_RS18540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18520"
                     /product="CAP domain-containing protein"
                     /protein_id="WP_037793202.1"
                     /transl_table=11
                     /translation="MQDHDREDRLGRVGRGHRKRRRKAPVLAAAAAVVLLAGGGGAYAL
                     LSGAAPERTAVAGAGVPSAPSALAGRPDPVVGGGALPAPTSTQAVSSSPRPVASVTATP
                     AAASPRASASASASASAHARPSKAAASSASGPAGPDPKVPGGRTSTQDVRTAQSLSLQL
                     LNAERAAVGRPPLALRQDLSDFARKWAEHMRTSGFSHSSSEERAYLKTGTRTWTGENIV
                     WFSDASMTAQEAAEKFQSMWRHSPGHYKAQVSPDFTEVGVGLHHDSSGWWGVHNFSDGR
                     "
     misc_feature    18144..18159
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.53"
                     /tool="antismash"
     misc_feature    18153..18169
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.45"
                     /tool="antismash"
     gene            18284..18499
                     /locus_tag="M444_RS18545"
                     /old_locus_tag="M444_18525"
     CDS             18284..18499
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102065.1"
                     /locus_tag="M444_RS18545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18525"
                     /product="DUF6243 family protein"
                     /protein_id="WP_008741458.1"
                     /transl_table=11
                     /translation="MTDSKNINNPVGQGGGQRKKLSRAERQNNGPHRNLDRKGAADQKA
                     ELIRKMREKTATPEAPEQPSDTPTQS"
     misc_feature    18873..18884
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            18877..19293
                     /locus_tag="M444_RS18550"
                     /old_locus_tag="M444_18530"
     CDS             18877..19293
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018517965.1"
                     /locus_tag="M444_RS18550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18530"
                     /product="hypothetical protein"
                     /protein_id="WP_037793199.1"
                     /transl_table=11
                     /translation="MTAIERLWEDFELPIKDALHYANGHSYDLALDAAAPTGFTVLAPL
                     DLHEVLEGDPSWVSSVDGLVAVDLGEKGLLWGGEGSHGSEGFIARLTVDRALIWAIFFT
                     ESNPFDRIRLSGNVATFSSTSGLEIELDIDDPVK"
     misc_feature    18887..18902
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    19009..19011
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19382..20200)
                     /locus_tag="M444_RS18555"
                     /old_locus_tag="M444_18535"
     CDS             complement(19382..20200)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950596.1"
                     /locus_tag="M444_RS18555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18535"
                     /product="DUF4365 domain-containing protein"
                     /protein_id="WP_037793196.1"
                     /transl_table=11
                     /translation="MTSCARSRTPAAVNCLRALLERHDHIVQEIDGQNDFGEDLYVTFT
                     VDGQTTGDMIKVQVKGGKSWRRSYGYGVPVAQHAETWADGNVPVICVVHDPEGEGLYWA
                     NATAQLLSARRERTVLKTIRVSSEALLDDHSLFEFVSQIRRYVGRYRGNRALLTELGEM
                     AGVDFDPADFVLHFINVHGEDLIFWQRRGEDFATLLHSDLDWHPQHITPGMLRLSGGLT
                     ASYKLDELPEWMRAFANVPTVGDIILDEDEAAWLAACFGASRWARDPEYN"
     gene            complement(20310..21884)
                     /locus_tag="M444_RS18560"
                     /old_locus_tag="M444_18540"
     CDS             complement(20310..21884)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="M444_RS18560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18540"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_037797917.1"
                     /transl_table=11
                     /translation="MATETERFAELMRGLKERSGRSYGTLAKRLHSSNSTLHRYCSGAA
                     VPTDYAPVERFARVCGASADELVALHQQWLLALVERRRAVTEGQASGSAAANSAAPRGG
                     DAAPEVPPASAAVVVAGEDSEVRPQAETDPASAPASAAGSAPAPGPAAAEAPAPAAATD
                     APEPAEPPAPAPAPAPAPAPAEDLAPAPAKEAPTHVRVDLVQPGPARASAPGARRPRLL
                     LAVAAAVATAAVAGIAATVSAMGDTGHGDTRRSAAQPSSRERAAGPALPSGGSSSPTPT
                     AASASPSSPGPSSPSGASASPSATSTSQATAKEGASSTAPFTVNVLPDNWDSPCDQWFA
                     LDKEPGAVPPPPAGQATEGWARALHAVPAGHLRMQLTVQGTEGKAAVLHALYVHVVSGR
                     KAPGWNAYTMGAGCGGALVPASFAVDLDDASPRARPVPGKEGERPTASTDFPYKVSATD
                     PQVLNIDAATLGQDVSWYLELAWSSGDRKGTTRIDDHGRPFRTVALNAGHSYWYNENNN
                     AWLPDTE"
     misc_feature    complement(22071..22085)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.2"
                     /tool="antismash"
     misc_feature    22072..22086
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.6"
                     /tool="antismash"
     gene            22214..22933
                     /locus_tag="M444_RS18565"
                     /old_locus_tag="M444_18545"
     CDS             22214..22933
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007268187.1"
                     /locus_tag="M444_RS18565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_18545"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_008741453.1"
                     /transl_table=11
                     /translation="MRTYRLRTTALAAATAGLALALTACGGTDSAGGPTTNPAATKSAD
                     KQVSTGTVTPSGEGASAAPSAGKATRTGTTTATPAKAGSSGKNTGDTTGDSYAYTHPCS
                     ARNLTVKVTSPTGAPATVRVITVTNNGSTSCGLDYFPTVGFSAKGGALGLQATAPGGLG
                     GAPAYPVHPGATAYAAVDLNPSGGNGPVADEVNVLADQEHMPNADGVSLQLAKPGSVAN
                     PKVGLYRTNTHDALSAF"
     gene            complement(<23193..>23312)
                     /locus_tag="M444_RS41060"
                     /pseudo=""
     CDS             complement(<23193..23312)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982322.1"
                     /locus_tag="M444_RS41060"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS481 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKLGPARSGPILGLPASAVHRILARHGLDRLAWLDRPTGE"
     misc_feature    23992..24007
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.08"
                     /tool="antismash"
     misc_feature    complement(24172..24187)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 16.37"
                     /tool="antismash"
     misc_feature    complement(24253..24273)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.24"
                     /tool="antismash"
ORIGIN
        1 gttcctcgga ctgctgctct ccgacagccc caacacgggc cagttcatca acagcaccat
       61 cgggcccgtc ctggagtacg acgcccagca gcgcaccgag ctcgcccgca ccctggaggc
      121 gtacttcgcc tcggccggca gcccgacgcg cgcggccgag agcctgcacg tgcaccccaa
      181 caccgtctcc cggcgcctgg agcggatcag cgaactcctg ggccccgact ggctggaacc
      241 cgcccaggcg ctggaggtgc agctggcgct ccagatgcag cgcacccgcc gcgcgctgct
      301 cagccggcgc cacgatcagg ccggccacgc catcggctga ggccgctggt cgcggtactc
      361 gctggacagc gcgtgcgcgg cggaggcgag cgtggtgtgc cggtgccagc cgccgaagga
      421 gcggccctcg aagtccacga tgccgacgcg ggtcgccacc tcggcgaagt cggtctcgac
      481 gcggtgggtg agcttcgcca ggcgcagcag cgcgccccac ggcacgtcgg tcatgtcggt
      541 gatccagcac tgccgcggcc agccgttggt gcccgtccac tcgccgagca gcagcagcgg
      601 ccgctgcacc cccggcagcc gcacctggac gccggcgacc aggctcgtcc ggctcgccag
      661 gcccccgggg tcggaccagg tcaccgggcg gcgcagcgtc cgtatcatcc gcagcagctg
      721 gtgcgcggag gtcgggcggc tgtcgttgcc gaggacggcc ggggtcgcgg gggccaccgc
      781 cgtggtgccc cgtacggagg ccaggtaggg cagccgggcg acgccgaggg agcgggccag
      841 ggccgtcggg ctgatgtccg ggaggtcgac gacgaccggg cgcgggctgc cgccgcccgt
      901 ccaggtccgc acctcggcca gggcgccggt cacgcactcc aggggggtcg cggcgaggtg
      961 cgcgtcctgc ggcagcgggg cggggccgag ccggtcggtg tcccgccagt cctcgcagag
     1021 catgagccgc cagttgacgg ggctgctcgt ctcctcgttg gcggcccaca ccccgaacgc
     1081 ctcctggctg ttgacgacct ggccgaggct gggcacgaac cggcgcgcga cgcccaccga
     1141 gtggcggccc gccttcggta tgaccaccgg gtgcaccacc caggcccggg ggcgcagcga
     1201 gcgctccagg tagcgggcga gggtggcgcg cacggggccc cagtcccagg tggaggacga
     1261 gatgaagtgg tgcaggctct gctcggccgc gcggtctccg acgtgggtgg cgatgttccg
     1321 catggacttg cggccgcccg cggaaagcag cccgcgcagg tacagctcgc ccttgcgccg
     1381 ctggtcgctg cgcggcagcg gtgcgaagat ctccgcgcac agccggccga gggcgtcgtc
     1441 cggaacccgg tggccgacct gctcctcgta gacgagctgc atctccatgt gtcccccgta
     1501 cgtcgtgccg tcgccccgct gtttccacgg gtctccaccg tgctgtccgg ggcggtggct
     1561 tgcccaggtg cgccggtcac acacctgggc ggacgagcgc gcctccggcc acccggaccc
     1621 gccgcgggga acgcgggccg gacggcgccg ggcggtccgt acgcccccgc ccgcctgcgc
     1681 ggacgccccg gggagcggcc cctggcggcc cggccgccgg atccggcgcc ggacggtggc
     1741 gggaccacac ccgcggaccc cgcggagggt ggcctcgcca ccgcgcggca ggtcacgcgc
     1801 gcccgcccgc gggggcggtc acgggtggtc gtaggtgggg tggggcgcgg gtggggcgcg
     1861 ggtggggcta acccccggcg cccgtctggg ggcagccggt tgggcggctg acgaccgctc
     1921 aacaacgatg tgggcatgcc tacttaccgc cgcaaggccg ctctcctcgc cctgtccgtc
     1981 gtctccgtcg ctacggccct caccggcgcc ggcgccccgc tcgcccgggc cgcgcccggg
     2041 gccccggcgt cctccctgga gtggaagccg tgcgcccggc ccggtggccc cgccgcccag
     2101 gaatgcgccg agctccccgt accgctcgac tacgcggacc cggacggccc ccggatcacg
     2161 ctcgccgtgt cccggctgcg cagcgaccgg cccgacgcgc ggcgcggcac cctgctggtg
     2221 atccccggcg gcccgggcgg ctccggcgtc cagcgcctga gccagaaggg gaacgccctg
     2281 tcccgggagc tggcgggcgc ctacgacatc gtcgccctgg acccgcgcgg cgtcggcggc
     2341 tccaccaagg cgagctgcgg cctggacccg gcggaccggt ggctggtcac cctccgctcc
     2401 tgggccggcc ccgacgggga gaccgccggg aacgccgccc gggcccgccg gatcgccgac
     2461 gcctgcgccc gcgagggggg cccggtgctg cgcagcttca ccacggccaa cgaggtccgc
     2521 gacaccgacc gcttccggca ggcgctgggc gagcggaagc tgtccgcgtg gggcgtctcg
     2581 tacggcacct acgtgggcgc cgtgtacgcg cagacctacc cccaccgcac cgaccgctgg
     2641 gtcctggaca gcagcggcga ccccgacccg cggcgcctgg cccgcggctg gctcgcgaac
     2701 atgtcccagg gcgccgacga ccgcttcccg gacttcgcgg cctgggcggc cgacccggcc
     2761 cgggacgccg agggcctgcg cctggccgaa caccccgaac aggtcgagcc gctgctcctg
     2821 gaactcgccg cgcgactgga ccgggagccg aaggaatccg acgtcgcggg caccccgctg
     2881 accggcaacg ggctccgcca ggcactccag aacgccctct acggcgacgc cctcttcccg
     2941 gggctggccc ggctggtccg cgccgcccag gacccggcgg cccggccgac gctcccgccc
     3001 gagctggccc ggccgctgcc ggacaccgac gcggccgtca tggtcggcgt catctgcaac
     3061 gacgtgcgct ggccgcaggg cgccgccggg tacgaggagg ccgtcgcggc ggaccgggcc
     3121 gcgcaccccc tgacggcggg gatgccggtg aacgtcaccc cgtgctcctt ctggaaggac
     3181 cggccgcggg aggaaccgac ccggatcacc gaccgggggc cgtccaacat cctgatgatc
     3241 cagaacctcc gggacccctc caccccgtac ttcggcgcgc tgaagatgcg ccgggccctc
     3301 ggcgaccgcg cccgcctggt caccgtcgac cacggcggcc acggcgtcta cctcgcgggc
     3361 accagcacct gcggcgaccg cgcagtgacc cactacctga ccacgggcac ccgcccccac
     3421 caggacacct actgcgcccc ctgacaccgg gggagttcgc gacccggcgg gtgcgggccg
     3481 tggttgtcag ggggctcggg gatactgcga gaggcaagca gcggccccag acctgtgaga
     3541 catgagggaa caccacatga gcacggccat gtccggaacc gtcacggcag caccgcgcgc
     3601 gtccggggga tggccgcgca gtgcgctggt cggggacgtg ctcatcaccg cggtggccgc
     3661 cctggagctg ctcacgctgc acgggcagct cgaccggacc gccgcgctcg tgtgtccgcc
     3721 cgcgctgatc gcgctcatgc tccggcgacg gctgcccgtg acggtgctgc tggcgacgct
     3781 gccgtcgatg gccaccgggt tcctgtggct cgcgcccatg gcggccatgt acaccgtcgc
     3841 ctcctgcgcc ctccgccgcc gggtggtcgt gggcgccggg gcggcgctgt tcgcggcgac
     3901 gctgtgggcc ggctacgccg tcggggccgc cgccatgacc tggagcgacc acctgatcgt
     3961 cgtccaggtg gcgctcatgt tcagcctcgg ccccgccggt ctgggcctgc tcgcccggac
     4021 ccggtccgag ctgcgggccc acgtcgccga gctgtccgcg tcgcaggcgc gcggccggcg
     4081 cctggaggcc gagcgggccg tcgcccggga gcgcacgcgg atggcccgcg agatgcacga
     4141 caccgtctcg taccacctcg gcctcatcgc cgcccagtcc ggggcgctgt ggagcaccgc
     4201 ccccgacgac acggtccgcg aggacgccga gacgatacgc cgccacagcg ccgacgccct
     4261 ggcggagctg cgcgacatcg tcggcgtcct gcgccacgcc gccggccggg gcgacgaggg
     4321 cgaccccgcc cggctggcca acctgggcga gctggtccgc gaggcccggc tggacgcggt
     4381 cctcgacctc gacctcggcc tccccgacgg ccgcggctgc ggcccggagg tcgagcaggc
     4441 cgcgtaccgc accgtccagg aagccctgac caacgtccgc aagtacgccc caggttcccg
     4501 catcgacatc cgcgtcgggc cgtccgccgc cggcgacgcc ctcctcgtcg aggtccgcaa
     4561 cggtcccgtc ccggaccctc ccgccggcgg cgccggtggc ggcttcggcc tcaccggcct
     4621 ggccgagcgc accgccctcg tcggcggtac cttccgcgcg ggcgccaccg cggacggcgg
     4681 tttcgccgtc cgcgccgaac tgccgctcgg tcagcggcag tcgccccagg gggagtccgg
     4741 gtccgcctcg tacaccgata cgtgccgcag gctcgacgag gtgtacgggg tgcccgccca
     4801 gtcctccgta cgctccacca gccgcagccc cgacagctcg gccagcaggt cgatctcgaa
     4861 ggggaaggcg tagcgcagca ggtgctcccg ggtctccggg gcgccgccgt cgatgatcgt
     4921 gtgggtcgac agcatgagct gctgcgagcg gtccacggtc agcgtgtcca gcatgatcga
     4981 ccgctcgtcg aggtggcgca tggagtggtc cggcttctcc atgtggtggt acggggccgg
     5041 gtcgaaggcc tccagtacga agcggccgcc gggagccagc tgctcgcggg ccagccgcag
     5101 gcagccgacc tgctgctcct tggtgacggc cacgaagaac gtgttcagca ccagggtcac
     5161 ggtgtcgaag gtccgccccg tgccctcccg cgtgaagtcg ccgagccgcg tggtcaccgt
     5221 gccttgcgga tcccgcgcgc gcagctcggc gagcatgggc tcggagccgt cgatcccgtg
     5281 caccgtgaag ccgtgcccgg cgagcggtac ggcgatccgg ccggtgccga cgcccagttc
     5341 gaggacgctg ccgccgggcg gggtgagcgc cgcgacgaac gcgaccgcct gctcggtgtc
     5401 gtggccgatc gggtacatgc ggtcgtacac gctcgccagc ttctggtcgt acagggcgtt
     5461 gccgagggtc gtggtcatgc gggcgctcac tccaaacggg gtgccggtgg ggcacggtcg
     5521 gtacgggggg ccggccccgc cgccgcccgg ccccggccca cgggacctcg gccgcgcctc
     5581 agcgggtgcc ggtgccggcc agggccggcg gccgcggccg gcccggaggg gacgcggcgc
     5641 ggtaagtggt gcggtggccg gtgcggtgcg tggcgcgatg ggtcgcgacc acggcggcct
     5701 gcacgcggtt ggtcaggccc agcttggcca ggatggcgct gacgtgctcc ttggtcgtgg
     5761 acgcgctcag cagcagccgg cggccgatgt cggcgttggt caggcccccc gcgagcaggt
     5821 ccagcacctg gcgctcccgg tcggtgagcg aatccaggcg ggcttccagc ccggcgtcca
     5881 gacccgggtc caggccggcg tccagcaccg gggtcaggcc cgggtccagc tcgtcgtacc
     5941 ccggcccgcc cccgtacgag ggcccgcccc cgtacgacgg gccgcccccg tacgacggcc
     6001 cggtgccgag gtagccgccc accacgatcc gggccgcctg cggcgacagc accgtgccgc
     6061 cggaggccag cacccgtacc gcgtggacga gttcctgcgg cgtcgcgtct ttgagcagga
     6121 agcccttggc cccggagccc agcgcggccg cgatgtcctc gtcggccagg aacgtcgtca
     6181 ggatcgccac ggccggcgga tccgtcagcg cgccgagacc ggccaggacg gcgaagccgt
     6241 ccacctccgg catgcgcagg tcgagcaaca ccacgtccgg acggtggagt tcgatcgccc
     6301 ccagcgcggc cgggccgtca caggcgaccg gaacgtcgat gtccggttcg ctctccagaa
     6361 tgcgctgcat gcacgagcgc agcaggactt cgtcgtcgac aatcattacg cggatcatca
     6421 cgcccccttg tggcggccac cccgtttggc cgcacttcgg ccaaggtatc aaccgggtga
     6481 aatggggttg aagtccaggg gtgcggctgg ggggaacgcg agctaccgcc caggggaagc
     6541 gctgccgcag ccggctcagg cgcccgcttc gatcgactcc tcgatgagtg cgaccatcgc
     6601 ggaatcccag gtcaggacca gcagttcggc cttctcaccc tgcgcggtcg tacaggtcag
     6661 ggccgttccg ccgcggccac cgccggtcgc cgccacggcc ggcccggcca gccgcagcgc
     6721 gctcgccccg gggccgtcca ggaccgctcc ggagcgcccc agcgtgagct tcccgggctg
     6781 catcccgctc gcccggccgg cggcggcgcc cgtacggtaa cggcaccgca gggtcaccgg
     6841 ttcgccgcgc cggaacgcgg cgacgcggcg cgcgcagcgg gcccggtcga ggcccttgcc
     6901 gcctatccac agcgtcaggt ccatcaggga atgcagcgcg aattccagca gcagcatgtg
     6961 atcgttcgct cctcaactca gacgactcgg ggatgacatg ggcggacacg ggtcacgggt
     7021 cacgggtcac gggatacggg tcaccggtgc gggccgcccc gcccggtcgc gtaccgcctc
     7081 gacgatggcc cgtacgtcgg ccagtgccgc ctcggggccc tcggtcagca ggaccccggc
     7141 gcagctcagc gcgatctccg tcgcccccgc ctcaccgtaa ccggtgagtt gggcggcgac
     7201 ctcctcaggt gtcccgtacg cgaagacacc gccgtcgacc agcgcgcccg cgcccgccca
     7261 cggatccgac acgtccacgt cgagcccggc cgagcgcagc atggccgcgt agtgctcccc
     7321 gctcaagtgc ggtgcgtgcg cggcgaacgc cagcttcctg ggatcgcggc ccggcctgcg
     7381 caccgcgcac ggcacgatcg ccgtcacccc cggcacgggc cgcccgcgcg acccggcgcc
     7441 ccgcgccaga gccggcacga tcgcctccct caggtgaccg gccggggtca gcagcgtgat
     7501 cgccacgtcc gcgatctgcc ccgccgtgtg cgccatccgc ggccgcagca cgcccacgcc
     7561 gagcgacacc cgcgggcagg gcgcggccgc cgccgcgtgc ggcagcggca ggggtccgcc
     7621 gtcgagccgt acgtagcgcc cccggaagtc ctcgaccgcc tcgccgtcca gcagccggcg
     7681 caccacggac aggtactcgg cgacggccgt gagcgggctc tcgtacggct ccccgcgcag
     7741 cgccgccacg aagtccgggt ccccggcgcc gaacccggcc accaccggcc gcccggtcag
     7801 cagcgccacg gaccgcgcct gcacggccgc gtccaggggg tggcgcagcg cggtcagcgc
     7861 gacgctggtc ccggcgggca cccggatgcc gcgtcccgcg aggtgggcga acgcctggtg
     7921 ggtgtcgacg accagcgact ggcccaggta caggcgctcc agcgccaggt cccgtacggt
     7981 ctcgccgaag gcggcgagct cgtcgaggtc ggaggccatc agcgggtaca tcagggacag
     8041 tggcgtcatc acgggcggcg cgggcgtcac ggggatcctc tccttggaca tcggggtcgt
     8101 ggtcgggctc gggggcgcgg tcatacgagg tccccggacc gttcggcggg ccccgcaccc
     8161 gacggcgtca ggtacgcgtc ggcctggagc cggaagagcc gggcgtacgt tcctccgagg
     8221 gccagcagtt ccccgtgcgt gccctcctcg atgagcgagc cgccgtccag cacgaggatc
     8281 ttgtccgcga cccggacggt cgagaaccgg tgcgagacca ccagcgaggt ggcccgggag
     8341 cagatggtcc gcaggcggcc gaagatgtcc gcctccgcct ccgggtcgat cgcggcggtc
     8401 ggctcgtcga ggatcgcgat cggcgcgtcc cgcaggaacg cccgggccag cgcgatcttc
     8461 tgccactgcc cgccggacag ctgccggccg ccctcgaagt gccggcccag cacggtgtcg
     8521 tacgtcccct cgaacccgtc gacgaacgcg tcggcgccgc tcgccgcggc ggccgcgcgg
     8581 atgcggtcgg tgtcgtcgag ctcctcgacc cgcccgaagc cgatgttgtg gcggaccggc
     8641 atctcgtagc ggatgaagtc ctggaagacg acgccgatgt tgcgctggag gtcggtggtg
     8701 tcgtactcct cgatcggcac cccgtcgatg aggatccggc ccgaggtggg ctcgtagagc
     8761 ctggtcagca gcttgacgac cgtgctcttg ccggcgccgt tcgcgccgac gagcgcgcag
     8821 caggtgccgg cggggacgaa gcagctgaag cggtccaggg cgacggtctc ggtgcccggg
     8881 tagcggaagg tgacgtcctg gaactcgatg ccgtgggtga ggcgccgcgg gaacggcagg
     8941 gtgccgcagg tgacgctccc ctcgggcagc gagaggtagt cgaagaggtt cccggtgaac
     9001 agggtgttct ggtagagggt ggcgacgccg agcagcagcc cgccggccgc cacgtgtacg
     9061 gcgccgagcg cctggaggta gccggccagc tcgccgaggc ggcccgtcga gacggtcgac
     9121 ttgagggcga agaccagggc cccggccgaa ccggccacgc tgaccagccc caggaccgcc
     9181 gaccagccgt gccggcgccg cgccaggccc cggtccaccc ggaagaactc ctggaccagc
     9241 gcccggtagc ggtccacgag gtacgggccg agctggtaca gcttcacctc cttgtaggag
     9301 gagtccgtcg tcgtcaggtc ctggtagtag aaggcccggc ggcggtcctg cgcgcggtgg
     9361 tactcgacgg cgtacccctc cttgctgaac acgatgtgcg cggcgagtgc gggcaccggg
     9421 gcgagcagga tgacgaccgc gagccaggcg ttccacgaga acagcaccga gctgaccatc
     9481 acgagcgacg ccagcgaggt gagcgtgcgc agcatctcct cgaacacctc gaaggccgtg
     9541 ccgccgccgc tctcgcgcag ggcgcgctgc agccggtcgt acgcctcggg gtcctcgtac
     9601 gagccgaggt ccatccgggt gcccttgacc atgacctgct cgccgatcgc ggccccgaac
     9661 tccagctgga gcagggagtt caggtactgc gcgaccgacg acaggacgtg ctcgccgacc
     9721 gcgaccgcga ccagcccggc ggcggcccgg gtgagccggt caccggcgcc cggaacgccc
     9781 tcgacggcgt cggcgacggc ctgcaccgcg tcggcggtga gccagatccc ggcggcgggg
     9841 acggcggcgg tcagcagggt gagcagcgcc agggcgctca cccgcagcgg gctgagcccc
     9901 cggaaggagc gcagcaccag ccaccagtag cgcaggtccc gggagagccg gcggtgcgtc
     9961 tgcgggtgtg cctgcgtctg tggctgcgtc tgctcggcgc tcactggggc ctcccgcgca
    10021 ggcagttcag tacgtggccc cacaccaggt agcagcggtt ctcggcgggc cggtccatcg
    10081 gcagcagccg gttcacctgc atgtgcgcga ggctcgccag gatggcgtcc cggccgcccc
    10141 acagggtccc ggcggcctcc gcccgggcga cggccagcgc ggcgcggcgt acggccgggg
    10201 cctgcgcgtc gaggacggcg gccagcagtc cgtggtgggc gcggccgagc gggtgcggcc
    10261 ggcgctccca ggggtggagc agttcgcaca ggtagtcgcg gtccttgcgg taccgctcgc
    10321 gggcctccgc gtcctgcgcg gggcggggca tggcggccag ccgctcgcgg atgccgagcc
    10381 cccactgggc gtagagcgcg tccacggcgg cgatgaccac ggcctcgggt tccaggccgg
    10441 gctcctcctc gtcccacagg aggcgcagca gccggcagga gacgtccgag ttcgcggcga
    10501 agagctcctc gacggcgtcg tggacggccg ggccgccgta gcggctgatc tccgggtggt
    10561 aggtggccac ttcgaggcgc tcggcgagac cgcgccggac cagcccctcg ccccaggcga
    10621 gcagcgcggg cagggccgta ccgggggcct cggcgggcgt cgccgtacgg acgcggatgc
    10681 gcaggtgggc gtcggggtcg gcgtaccgga tgtagaacca ccggtccgga tcggcgcccg
    10741 cttccctcaa ctggggcagc agggcaggga gttcggtcgc ggcgatctcg tcgtggaggt
    10801 cccgggccgc gtacagcttg aggtacgacc atgcggagcc gggcagatgg gcggggtgcg
    10861 ccgagggcgc ggccttgcgc cggatctcct cgggggcgag gccggagccg ctctcccggg
    10921 ggatctcccg ggcgccctcc ccggccccgg tggcgatcag cgggatgacg acctccgaga
    10981 ggtggccgcg ccccgagccg tcccgcagcc atgcggagtc cggaccgggc agcgcctcgt
    11041 ggagggtgac gcggccggag ccggagccgg ccccgccgtc cagctcggcg aggagttcgt
    11101 ccacgcagag cggatggtcg aggtcgagga gcagccggtt gtcgtcgtcc gcgaggtaga
    11161 cgtaccgggg cacctcccag tcgcgccgcc agcgggccac ctcgtccgcc gaacgcggca
    11221 ccggcaccgg cccgcccgcc gcgggggcgg cctgcgcccc cgccgggtac aggttccact
    11281 cggcggcgcg tacgacgacc cggccgcgga cgacgcgcgg caggtgcggg gcgccctcga
    11341 cggggcccca gccgaaaccg gcgggggtgg cgtaccgggc ccgggagacc tccagcagga
    11401 agcggcagac gttgggcgcg ccgtacgggc tgagcatgtg gttctggacg acgacgagtt
    11461 cgcgcccgag ccgcgccgag tagaggcgca ggccctcgtc ggccgcgccg acgtggatgt
    11521 cggcgaggtc gatgacctgc tccggggcgg ccgtcggcgc gacgttgacc gggatctcgt
    11581 acgcgtgcac cgccggccgg atcgccacgt tcgcgccgcg cccgttggcg ggcaggtacg
    11641 ccagctcggc gacgacgacg tccggttcca gggcctcgcg ggcgcgggcg taggcgcgca
    11701 gccgatcggt ggcgtccgcg ccgagcaggt ggccgaaccg gccgaaggtg cgaccgccct
    11761 cgccgaggcc gtcggggttg aggacggccc gccactcgcc ccggtcgatg gcctcggggc
    11821 cgtccgccgc gatctggacg tacgcgtcga ggcccgggca gtcggggcgc ccggaaaggc
    11881 ccgctgagtc cgtggcgttc gcggcgtccg ggggcagcag ccggcggagc acctcgtcgg
    11941 tcagctcgac ctcgccggcg ccgcgccgcc acgcgtcggc cgcgagggcg acgagcgccc
    12001 gggcggtgtg cgggtcgtcc tcggcgacgt gctggttcag ggccatggcg cgcggcgggg
    12061 tcaggtagcc gcccggcgcg tccaggccgc gttcggcgcc gagcaggtcg aggacgggga
    12121 cgagtgcgtc ggagccgtac cgctccatga acgcctggtg gtacgcgccg aggtggtcgt
    12181 acccggcggg cgcggcccgg cccagctcgg ccaggcagcc gacggcctcg gcgacctcgg
    12241 cggcgatctg ccggttcagg tcgggcgcgg cgaggtcgag ggcggagtcc acctgcgacg
    12301 gctggccctt gtggaggggt acgagggccc gctgggcggc gcggagccgg cggagggcgt
    12361 cggtgtcgcc gtacggcgcg cggccggtca gcccgacgat ctcgcggagc gcggccaccg
    12421 ccgggtggtc gactccggcg gcggtgagcc ggtcgaggac gtacgcctcg gggcgcggct
    12481 cggtgacggg cggccgcagg tcggtgacga gcaggcccag cccgaccagc tcggtgacga
    12541 acgcgctgat ccgctcccgg ccggccgcgg ggaattcctc ggccagctcg gtgaccagag
    12601 tggcgtacgg gaccggcgcg gcgggcgggg cgagcgcgcg gatccgggcg aggggggcgg
    12661 tgtggcggac gcgtacggcg cggcggtcgg aggcgtcgcc gtgcactccg gaggagggca
    12721 gtacgagccg gtcgcccacc cggtgggcca tggcgttgac ggacaccccg agccgggcca
    12781 gcgactgcgg gtcctcctcc aggcgctgca ccagggcgag cagccaggcc gtgtcggccc
    12841 gtacgtgggc ctcgccgagc gcggtggcgc cgaggcgggc ggtggtggtg tccccgaagg
    12901 tgccgagggc gacgccggag aaggcgccga agggggtggg gcgggtgctc atccgggtga
    12961 ggtagcgcag ggcgcgggag tgcacccgcc gcgcctcctt gccggaaccg gaaccggaac
    13021 cggaccccgg cgccgagccg tcgagcttcg ccagcccgtc gagcagcccg ctcccggcgg
    13081 cgacgagccc gtgccggacc cgggggtcgt cggcgagggc gcgcagcagc cgggcccggg
    13141 tgcgctcgcg gtcggccccg tcgagggcgt cccgccagac gccgacgggc agggccggcg
    13201 cgcgcaggag gtggaagtcg agggcgtggt accgctgcat ggggcgggtc ggttccttgc
    13261 ggggctcggg aagggaaggg tcggggcggt aagggcggta agggcggtcc ggctcaccgg
    13321 gggaacagca cgctccacca gccgggccgg tggccggtgg ccagggcgcg cagggtgagc
    13381 gcgatgccgg cggctccggt gagcagcccg gggttgtcga cgacgtgccc ggtggtctcg
    13441 tggtcgcggt agagcaacgg cagcccgggg tcggcggcgt ccaccagccg cagggcgagg
    13501 cccggcaggg cccgggcggc cccggcgctg ccgtgcgcgg cgaactcgtg ggcgagcgcg
    13561 gcgatcccgg cgagcccgtg gcacacggtc ggcgagcgcg gtacgtcccc accggcgacc
    13621 cggtcgagca gcccgtcgag cgcggcgaac gcccgcgcct ccaggcccgg atcgccggtc
    13681 gcgcgggcga cggccagcag cccggcggcg acgcccccgg tgccgtggca ccaggcgggc
    13741 gcggcctcgc ggccgtcggc cggcacgacc cgcgaccacc gcagcccgcc cgcaccgccc
    13801 gagctcccgc cgcgcccggg tcccgcgcca ccgtcgccga cggccagcag ccatccggtc
    13861 agctcgtcca gggcggcgcg ttgccccggc acccgccggt cccggcgcca cgcggcggcg
    13921 agggcggccg cgatcccggc ggcgccgtgc gccatgccgg tgtcgagccg gccgcccacg
    13981 gcccagttcc cgtcggcggc cacccacacg aggtggcgca ggcaccgctc cagggcctcc
    14041 tcgacgagcg gggtcgcggg cgcggccgca cagagctgta cggcgatccc ggcggctccg
    14101 tacaccaggt cgtagtggtg gtcggcgacg gcgccgggca ccctcggcca gtcggcgtcg
    14161 atcacctgcc gggccagctg ttcgtggagc cgcccgagac tggggaggaa gcgaggctcg
    14221 tcgcgggaca cgtcctggag ggcgaaggcg agcccggcgg tcccgtcgaa cagaccgggg
    14281 tggtgcagcg ggctctgccc ggtggcggcg aaagcggccc gcgtgaaggc gcgggcgcgg
    14341 ccctgcccct cctcccgccc ggcggcgtgc cggtgcagga gggcgaggcc ggcgtgcccc
    14401 tcgctgaggg aggcaccggt ccagaaggac acgtcgctct ggcgggcggc gcgtacggcg
    14461 gcggcgtcgg cgtgcgcagg ggtgtcgagg cgctcggcga tcaggccggc cacggcctcg
    14521 gcccgggcgg cgagcccggc cggaagggac ggtacgacgg tcatggatgg cctagcgggc
    14581 ttcggtacgt gcggtgcatg cggtacgtgc ggtgcatggg gcgccgcggc ggatcctcgg
    14641 aggaggcccc tcgggggagg cccccggccg ggaaacggcc ggggaaccca ccactcgacg
    14701 cgaacggcgt tggtgtggtc agcacttgcc gttcgtacgg acggcggcgc aggccgctgt
    14761 catcttgatc gtctgcttga tcgtctgctt cacgacggcc ttgctgacga tgcgcgaggc
    14821 gatgctcgcg gcaggggaca gctgggtctc ggccgggtcg gcggaaacgg tcacgcgggc
    14881 gtcgaggtgg aactcgtcca tcggtactgc acctttcatc tcacacaagg ggccgccccc
    14941 cgtgtcggaa caccggaagg cgttccggtg gcggcccgga aatgaaatta ccgacgggcg
    15001 cgagacggca gtacccgccg aatttccctt tcccaccccg ccgttcggcg gccgcgggac
    15061 cgccggtcag cgggactgga gggcgtccag tgcgacggcc atgcacaggg cgaggacccg
    15121 gtcgagcgag gggtcctgga cgcggatcac gtagcggtcc cgtatgcccc acttccgctc
    15181 gacggacagg acgggcttgt cctcccgcac gaagtcgaag tggtagacga acggcaccgg
    15241 cggtacgggg atcacgggga cgacgaagtc gagcagctcc cacccgcgcc gcgcgagggc
    15301 gaccccgagc cgccgttcct tgccgatcgc ggcggcctcg tccccctgcg tcaggtgcca
    15361 ggtggagcgt atgagggacg ccttgacgtc cttgcggaac gtgccgatcg tcgccccgtc
    15421 gggccggctg acgtcgtacg tggccccgaa gtcgatgacc tgccgggcct tgaacccccc
    15481 gagccggcgg gtccggtcct cgccgctcca gagggtcagt tcctccttca gcgcgagccg
    15541 cttctgctcg gcgaacgcga ggacctgccc gccgtccggc gtcgtgaccg tgtagcggtt
    15601 gaccagcggg gtgatcttct gggtcatcag atattcgttc aggtgctcca tacgggaacc
    15661 ctaggcagcc cggggttccc cctcactacg cctgagggcg gaacgcaccc ccgccgaccg
    15721 gcgggtacac ccccgccgac cggcgccccg gccccgccct atccgtcacc ccggccggat
    15781 ccggcgtcca gccacagcgg atgctcccgc gccgcccagg accgcgcgac cgacccggtg
    15841 cgcatgcccc ggcgcgcctc cggatcggcg agcgcccgtc cgatgtgccc ggccagcacc
    15901 acgccgatcg ccagggccag ccagtcgtgc acgaaggtgg cgctggtgcg ccacaccagc
    15961 ggcgccaggt gcgtgaacca catcagcagc ccggtcgcca gcatcaccaa ggcggcgccc
    16021 gcgatccacg acgcgtagag cttctgcgcg gcgttgaact tccccgcggg ccgggacgcg
    16081 cgccggcggt cgcgtcgccg ggccgcgcgc agccacgtcc ggtcgtgcgg cccgaagcgg
    16141 ttcagcctgc gcagatcggc ccggaacgcc ggggatccga gcccgagcag gaagggcgcg
    16201 ggcaacagga tcccggccca ttcgtgcaca gtcacgacga gctcccgacg cccgacgagt
    16261 tcggcgacct gcggtacgta cagggcggcc gcggtcgcca cgcacagcag caccagagcg
    16321 gccgtcgtac ggtgcgtcca gcgctcggcc cggctgaacc tccgtacccg cgcgcccggt
    16381 tcagacggtg ggggcgtcgc cgcggccgtt ggaccggccg acccaggcgt cgacgtcata
    16441 gccgcgctcc tcccagtagc cggggcgcac ctcggaggtg acggtgatcc cggagatcca
    16501 tttcgccgac ttgtagaagt acatcggagc gacgtagagc cggaccgggc cgccgtgcgc
    16561 gtggctgacg ggctcgtccc gcatccgcag gcagacgagg acgtcgtcgc gccgggcctg
    16621 cgggagggtg aggctctcgc tgtacgcgcc gtcgaagcag gtgaagcgga tcgcccgggc
    16681 cccgggacgc accccggcgg cgtccagcag gagcgacagc ctcacgccgg agaaggcggt
    16741 cgcgggcacg cgccagccgg tcacgcactg cacgtcccgt acgacacggg tctgcggcag
    16801 cgcgcgcagc gcgtcgaggc cgtacgtcgc ggggcgctcg acgagcccgt ccacggtgag
    16861 ccggtagtcg ccctcgggcc gccgcggcac ggaggaggcg acggagtagt agcggaaccc
    16921 gcccccgttg gggagcagcc cggtgaggcc ggtggggtcc ttgtccgagg cggccccgag
    16981 cagggcctcc gtcccgcgct gcacgtacgg cgcggcgacg agccccccgg cgccgagccc
    17041 gagcatgccg agcaccacac ggcgtccgac gggggcgccc tcgctgtcgg gatggtctgt
    17101 cgtcacgccc cgagtcgaac accgcgcgcc acggatgacc agcgaaaccg ccgtgacgtc
    17161 agacttccgt catcacctgc cgtcggagaa gttgtgcacg ccccaccagc ccgaggagtc
    17221 gtgatggagg cccacgccga cctcggtgaa gtcgggactg acctgcgcct tgtagtggcc
    17281 ggggctgtgg cgccacatcg actggaactt ctcggcggct tcctgggcgg tcatcgaggc
    17341 gtcgctgaac cagacgatgt tctcgccggt ccaggtccgc gtgccggtct tcaggtaggc
    17401 gcgttcctcg gaggaggagt gggagaaccc gctcgtccgc atgtgctcgg cccacttgcg
    17461 ggcgaagtcg ctgaggtcct gcctgagcgc gagcgggggc cggccgacgg cggcccgctc
    17521 ggcgttgagc agctgcaggg acagcgactg ggcggtccgg acgtcctgcg tagaggtacg
    17581 gcccccgggc accttggggt ccggccccgc cggcccgctc gccgacgacg cggcggcctt
    17641 ggaagggcgc gcgtgcgcgg aggccgatgc ggaggccgac gcggaggccc tcgggctggc
    17701 cgccgccggg gtggcggtga cggaggcaac cgggcgagga ctgctggaga cggcctgggt
    17761 gctggtggga gccggcagcg caccaccccc caccacagga tccggccgac cggcgagcgc
    17821 ggagggcgcg gagggcaccc ccgcccccgc gaccgctgtc cgctcaggcg ccgcaccgga
    17881 gaggagcgcg taggcacccc cgcccccggc gagcagcacc acggcggccg ccgccgcgag
    17941 caccggcgcc ttgcgccgcc gcttccggtg cccccggccc acccgcccga gccggtcctc
    18001 acggtcgtga tcctgcatcg catctcctcg aagccgacgg cccacctggc ctgacacaga
    18061 gggagactcc cgggccccgc ggagataaca ccttcctcgc caggaccggc gaacgacttg
    18121 gtgcgcggcc ccgacggaac cgggtaacgt ctttgtcatg ttcttccaga cgccgattta
    18181 cgagcgtggg gcgtgacggg cccccgctga cgcccttcga cgtcgccgcg cccgcccccc
    18241 acccatgaat ccgtagatca ctccacagtt accgggagaa cccatgaccg acagcaagaa
    18301 catcaacaac cccgtgggcc agggcggcgg ccagcgcaag aagctgtccc gcgccgaacg
    18361 ccagaacaac ggcccgcacc gcaacctcga ccgcaagggc gccgccgacc agaaggcgga
    18421 gctgatacgc aagatgcgcg agaagaccgc cacgcccgag gcccccgagc agccgagcga
    18481 cacccccacc caaagctgac accccccgcc acacggccag ggcccggacc gcaacacgcg
    18541 ctctgggccc tttttgcctg acgcggagac cggccccggc cagccgccgg tcacacccgc
    18601 caacctcacg atcggctcgg gccgctgacc gtacgatccg gcaggccgcc cggttgcgga
    18661 aaccgacgtc gacggcgcta cgcgcacgta cgaacgcggg aaaccgcccg ctacaccaca
    18721 ccacaccgga cccactcggg ctggttgtgg ggcttgccgg ggagccgaag gggaggccgg
    18781 tgaccatcga gcgcgtcgac cggaccgcag tgcaccaccc tgattcgaca accggacgga
    18841 cacgggcgga tgaattcaga aggcgaacca gaataaatga ccgcgatcga acgcctatgg
    18901 gaagactttg agctgcccat caaggatgca ctccactatg ccaacgggca ctcctacgat
    18961 ctcgccctcg acgccgccgc gccgacgggt ttcacggtgc tcgccccctt agatctccat
    19021 gaagtgctgg aaggagaccc gtcgtgggtg tcttcggtcg atgggcttgt cgctgtagac
    19081 ctgggagaaa aggggctgct gtggggcggc gagggttcgc acgggtcgga ggggttcatt
    19141 gcgcgtttga ctgttgaccg cgcgctaatt tgggcgattt tcttcacgga gtccaatccg
    19201 tttgatcgga ttcgactgtc aggaaacgtc gccaccttca gctcgacctc ggggttggag
    19261 atcgagctcg acatcgacga tccggtgaaa tgagcatcag ccgattttcg cggcctttca
    19321 ctgcgtctgc aattggctgc gatataccgc cccactggca cggtcctgat acgcgcgacc
    19381 ttcagttgta ctcggggtct cgggcccatc ggcttgcgcc aaagcaagct gccagccacg
    19441 cggcctcgtc ctcatcaagg atgatgtctc ccaccgtggg tacgttggcg aaggcgcgca
    19501 tccactcagg aagctcatcg agcttgtagc tggcagtgag tcccccggag agacgcagca
    19561 tgcctggcgt gatgtgttgg ggatgccagt ccagatcact gtggagcaag gtggcgaagt
    19621 cttcgcccct tcgctgccag aagatcagat cctcgccgtg gacgttgatg aagtgcagga
    19681 cgaagtccgc cgggtcgaag tccacgccgg ccatctctcc aagttccgtg agcagggcgc
    19741 gattgccgcg gtagcgcccg acgtaacgac gtatctgaga gacgaattcg aacagggagt
    19801 ggtcgtccag cagtgcctcg gagctcacac ggatggtctt cagcaccgtt cgctctcgtc
    19861 gggcacttag caactgcgcc gtggcgttgg cccagtacag cccttcgccc tccgggtcgt
    19921 gcaccacgca gatcaccggg acattgccat ccgcccacgt ctcggcatgt tgcgcgacgg
    19981 gcacgccgta gccgtacgag cggcgccagg acttgcctcc cttcacttgg accttgatca
    20041 tgtcgcccgt cgtctggccg tcaacggtga acgtgacgta caggtcctcg ccgaagtcgt
    20101 tctgaccatc aatctcctgg acgatgtgat catgtcgctc cagcagcgca cggaggcagt
    20161 tgactgctgc gggggtacgc gaccgggcgc agctcgtgat cgcggcgtac gaaccggggc
    20221 tcgtcgttcc cggcgactga ccacgatggc ggcgccgggc ctgcgtctcc ggaccgcggc
    20281 cgcttttcgg accgggtgca atgggtcttt cattccgtgt ccggcagcca ggcgttgttg
    20341 ttctcgttgt accagtagct gtggccggcg ttcagggcga ccgtgcggaa cgggcggccg
    20401 tggtcgtcga tacgggtggt gcccttgcgg tcgccactgc tccaggccag ctccaggtac
    20461 cagctgacat cctgaccgag tgtggcggcg tcgatgttca gcacctgagg gtcggttgcg
    20521 gagaccttgt acgggaagtc ggtcgaggcc gtcggccgct cgccctcctt gccgggcacg
    20581 ggcctggccc taggggaggc gtcgtccagg tccacggcga aggacgccgg caccagcgcg
    20641 ccgccacaac cggcgcccat ggtgtaggcg ttccagccgg gagccttgcg gccgctcacg
    20701 acatggacgt acagcgcgtg caggaccgcg gccttgccct cggtgccctg gacggtcagc
    20761 tgcatgcgca ggtgccccgc cgggacggcg tgcagggccc gggcccaccc ttcggtcgcc
    20821 tgcccggcgg ggggcggggg gaccgcgccg ggttccttgt ccagggcgaa ccactggtcg
    20881 caggggctgt cccagttgtc gggcaggacg ttgaccgtga acggggcggt ggaggaggcc
    20941 ccctccttgg cggtggcctg cgaggtggac gttgccgagg gggacgcgga cgcccccgag
    21001 ggggacgacg gtccggggct ggacggggat gcggaagcgg cggtgggcgt gggtgacgac
    21061 gacccgccgg acggcaaggc cgggcccgcc gcccgctcgc gcgaggacgg ctgggcggcg
    21121 ctgcggcgcg tgtccccgtg acccgtgtct cccatggcgg agacggttgc ggcgatcccc
    21181 gccaccgcgg cggttgccac ggcggccgca acggcgagca gcagccgagg acgccgggcc
    21241 cccggtgcgg aggcccgggc ggggcccggc tggacaaggt cgactcggac gtgtgtgggt
    21301 gcctccttcg ccggtgcggg ggcgaggtcc tccgccggtg ccggcgcggg agcgggggca
    21361 ggcgccgggg cgggtggctc cgccggttcg ggtgcgtccg ttgccgctgc gggggcgggt
    21421 gcctccgcag cggcaggtcc gggcgccggg gccgacccgg ccgcggacgc cggcgccgat
    21481 gcggggtcgg tctccgcctg cggccggacc tccgaatcct ccccagccac caccaccgcc
    21541 gccgatgcag gcggcacctc cggcgcggcg tcaccgcccc gcggcgccgc ggagttcgcc
    21601 gccgccgacc ccgaggcctg cccctccgtc accgcccgcc gccgctccac cagcgccagc
    21661 agccactgct ggtgcagcgc gaccagttcg tcggccgagg caccgcagac tcgggcgaac
    21721 cgctccaccg gggcgtaatc cgtaggcacc gccgcgccgc tgcaatagcg gtgcagcgtc
    21781 gagttgctgg agtgcagacg cttcgcgagc gtgccgtagc tgcgccccga gcgctccttg
    21841 agtccgcgca tcagctccgc gaaccgctcc gtctccgtgg ccattccacc ctccccctca
    21901 tcccggaagc acgttccagg ctcgcccgat cgcccaggtg agaggggtcg ggagcgttcc
    21961 agggttccaa ctatcccggt ccagacgcca ctggaacgaa accggcccca cagttgcgtc
    22021 atcagccggt cggtccgcca tcggatcggc ggtcggatcg ggcggtcgca acgggagggc
    22081 tcccacccgc cccaccgacc gccctcggcc gcctgcggca gcagccgacc ggaacagcag
    22141 ccccacccaa cgtctcgtca gacgggaagc ggaagcctcc gtctgacggc ctcaccgaca
    22201 cggagagttc cccatgcgca cctaccgact ccgcaccacc gccctggccg ccgccaccgc
    22261 cggcctcgct ctggccctga ccgcctgcgg cggcacggac agcgccggcg ggccgaccac
    22321 gaaccccgcc gcgaccaaga gcgcggacaa gcaggtctcg accgggaccg tgacgccgtc
    22381 cggggagggc gcctccgccg ccccgtccgc cggcaaggcc acccgaaccg gcacgaccac
    22441 cgccaccccg gcgaaggccg gttcgagcgg caagaacacg ggagacacca ccggtgactc
    22501 ctacgcctac acccacccct gctcggcgcg gaacctgacc gtcaaggtca cttccccgac
    22561 gggcgctccg gccaccgtcc gcgtcatcac cgtgaccaac aacggttcca cctcctgcgg
    22621 tctggactac ttccccaccg tcggcttcag cgccaagggc ggcgcgctcg gcctccaggc
    22681 cactgccccc ggtggtctgg gcggcgcccc ggcgtacccg gtgcaccccg gcgccaccgc
    22741 gtacgcggcc gtggacctca acccgtcggg tggcaacggt cccgtggccg acgaggtcaa
    22801 cgtcctggcc gaccaggagc acatgccgaa cgcggacggc gtcagcctcc agctggccaa
    22861 gccgggcagc gtcgccaacc cgaaggtcgg cctgtaccgc accaacaccc acgacgcgct
    22921 gagcgccttc tgagcggagt tccgggggcc gcggcccccg gccgtcccac ggggtgtgtc
    22981 gccgggcggg ctcaaccgtc tgggcgaggg aacgccagac aaccgcctcg ccgaactcag
    23041 ggcagtccga gacgagctca agcccctgga gcgtgagttg gccccgctcc gggggcaaga
    23101 tcgacaagct gcaccagcgc cgggacgaaa tggtccggcg gttcggcggg tacgacaagg
    23161 ccactgcggg ccgactcgcg acgtacgtcg gtctcgccgg tgggccggtc cagccaggcc
    23221 aggcggtcca ggccgtgccg ggccaggatc cggtgaacgg ccgaggcggg caggcccagg
    23281 atcgggccac tgcgggcggg gccgagtttg cggctctgca cggaggctgt cgaggtgctc
    23341 gacggcgtag cgcaggccct gggcccggac ctggtcccat cgcgcggcct cccggcgccg
    23401 acgcagccac agcgcgcccg cggcaccggc tgcgagcagg ccgaccacca gaacccaagg
    23461 acggacggcc agccacgaca gcactgccac gacgaggctg agggcgacga ggccggccag
    23521 gccgatgggc cacagctcct ccgagccggt ggccttccgg cgccgcgctg cgccggtgtg
    23581 cctgcgcctc ttcgcgggtg ggcgggggct cacctgtcgt tccccgtgct gggcaagacg
    23641 accggatagg agaccgtcgg tatcggtggg ggcgctgggc ggttctccca cgccggccat
    23701 ttgatcgggt aaaccaccgt cgactgcggc ccgggtaact cctggcccga gcctgctccg
    23761 gcccccgcag atggttccgt tcccgaagac gatcactccg gcgacgatca ggccgagcag
    23821 cgcggtctcc cgccgggccc cggcagggag ccggacgtgg cctttgaccc gagtgccgtc
    23881 tgcccggaag tagtcattga tccagggcac agctgtgtcc ccccaccagt cgtgatgcgc
    23941 ctccctgcgc accggactca tgaaacaccc gccactgaca acgcgtcacc tagaggtcta
    24001 gacaacgacg aaggcccagg tcggtgacct gggccttcgt atctgagcgg atgacgggaa
    24061 tcgaacccgc tctataagct tgggaatcac tcggcgcttg agccgcatgt ggtctctgac
    24121 ctgcgaaaac atgcccttgg ccgcgtcggt gcggggctcg gtcgcaccag ggttgacccc
    24181 tgttgaccgc cctgactggc acgtagtggc acgctggggc caagctccac ggcctggtcg
    24241 cccaggaccg cctgatcgtc acagtcacga acctgacagc gtccggcagg cgaggacact
    24301 gccgaggccg gtggtgcatc tgttgacggc cgacagcctc ggcccccagg tcaggggctg
    24361 ggcagcagct cgagcccgag ccttcgggtc ctggtcaggc tgtagggcgt tcctgcgagg
    24421 gtacgggggg aaggcgaaag gctgaggatc atcggtgggc ccgcgaacgg attccctcct
    24481 catgtgtgct gaatgcgttc cggggcagtc tgcccgccag ggcgcccgcc ggcagactcg
    24541 tacagctgac gcccgacgta ctgc
//
