LOCUS       NZ_CP011664            24670 bp    DNA     linear   CON 03-MAR-2024
DEFINITION  Streptomyces sp. Mg1 chromosome 1, complete sequence.
ACCESSION   NZ_CP011664
VERSION     NZ_CP011664.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. Mg1
  ORGANISM  Streptomyces sp. Mg1
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     De Novo Assembly of the Streptomyces sp. Strain Mg1 Genome Using
            PacBio Single-Molecule Sequencing
  JOURNAL   Genome Announc 1 (4), e00535-13 (2013)
   PUBMED   23908282
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (02-JUN-2015) Biochemistry and Biophysics, Texas A&M
            University, 300 Olsen Blvd., College Station, TX 77845, USA
REFERENCE   3  (bases 1 to 7868178)
  AUTHORS   Hoefler,B.C., Konganti,K. and Straight,P.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-JUN-2013) Biochemistry and Biophysics, Texas A&M
            University, 2128 TAMU, College Station, TX 77843, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Celera Assembler v. 8.2
            Genome Coverage                   :: 30X PacBio; 80X Illumina
            Sequencing Technology             :: PacBio + Illumina MiSeq/HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 03/03/2024 08:10:05
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,822
            CDSs (total)                      :: 7,726
            Genes (coding)                    :: 7,467
            CDSs (with protein)               :: 7,467
            Genes (RNA)                       :: 96
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 260
            CDSs (without protein)            :: 259
            Pseudo Genes (ambiguous residues) :: 0 of 260
            Pseudo Genes (frameshifted)       :: 109 of 260
            Pseudo Genes (incomplete)         :: 200 of 260
            Pseudo Genes (internal stop)      :: 18 of 260
            Pseudo Genes (multiple problems)  :: 60 of 260
            CRISPR Arrays                     :: 11
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:43:08
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3564823
            Orig. end                         :: 3589493
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP011664.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Paul Straight
            (paul_straight@tamu.edu).
            Annotation modified by the submitter.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24670
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="12"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24670
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24670
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14670](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14670
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(504..519)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.91"
                     /tool="antismash"
     gene            complement(846..1823)
                     /locus_tag="M444_RS15185"
                     /old_locus_tag="M444_15165"
     CDS             complement(846..1823)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003968470.1"
                     /locus_tag="M444_RS15185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15165"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_008743009.1"
                     /transl_table=11
                     /translation="MATRAVARRQSSSSARAVGGEIADRDLVGMYLDEIARTPLLDAAK
                     EVELSQIIEAGVYARQILDGEAEREGEAPAREELEALAAEGERAKEVFIRSNLRLVVAV
                     ARRYPRSGLPLLDLIQEGNAGLVRAVEKFDYAKGFKFSTYATWWIRQAITRSIADQSRT
                     IRLPVHLVEELGRIRRVQREFNREHGRDPEHTEIAAELDTTAKRVGDVLDWARDPVSLN
                     MSVDDDGDTQFGDLLEDTSAISPEQSVLSLLRSEELEDLLGKLDQRTASIIKMRYGIDD
                     GRERTLTEVGKQHGLTRERIRQIEKHALLELKKMARDTGFDAVA"
     misc_feature    2038..2058
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.09"
                     /tool="antismash"
     misc_feature    2082..2098
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     misc_feature    complement(2108..2123)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            2368..3018
                     /locus_tag="M444_RS15190"
                     /old_locus_tag="M444_15170"
     CDS             2368..3018
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985227.1"
                     /locus_tag="M444_RS15190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15170"
                     /product="Uma2 family endonuclease"
                     /protein_id="WP_008743008.1"
                     /transl_table=11
                     /translation="MTALAHEMLEAPMPKAATPPSELDEALWQAWKAMELPEGFHAEII
                     EGFIEVSPTGRLPHSKITNGLRRTLDRFLERGEFAAFQDTNVIHGQKVWIPDVLIAPED
                     VDIHGTEDGIGIRAEAVRLVVEVVSPGSDSITRDRTRKRRAYARAGIPVYVLIDDYDDG
                     GTVTVLSRPDREKAIYGDEVRAAYGAAVTVPEGPAKGFVIGEDITGAGQPRRG"
     gene            complement(3025..3804)
                     /locus_tag="M444_RS15195"
                     /old_locus_tag="M444_15175"
     CDS             complement(3025..3804)
                     /EC_number="1.13.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015034261.1"
                     /locus_tag="M444_RS15195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15175"
                     /product="class III extradiol ring-cleavage dioxygenase"
                     /protein_id="WP_008743007.1"
                     /transl_table=11
                     /translation="MSATTRIPVLYLSHGAPPLADDPLWPGELAAWSADLPRPRAILMV
                     SAHWEEAPLALGATERVPLLHDFRGFPEHYYRVRYDAPGAPGLAASVRGLLRAPGTPVQ
                     DVPDRGLDHGAYVPLVEMYPQADVPVLQISLPTLDPARLMGIGRKLAPLRDEGVLIVGS
                     GFFTHNLAALRHRGPGVPAWSAEFDAWGREALAASDVDALLDFERKSPAGRLAHPRTEH
                     FAPLFVTLGAAGPDLAAPRTPVDGFWLGLSKRSLQFG"
     gene            complement(3914..5458)
                     /locus_tag="M444_RS15200"
                     /old_locus_tag="M444_15180"
     CDS             complement(3914..5458)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577555.1"
                     /locus_tag="M444_RS15200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15180"
                     /product="MFS transporter"
                     /protein_id="WP_008743006.1"
                     /transl_table=11
                     /translation="MPKTAATSPLAADPSRWKALVFIALAQLMVVLDATIVNIALPSAQ
                     SDLGISDGNRQWVITAYALAFGGLLLFGGRIADKWGRKNAFIVGLIGFALASALGGAAN
                     GEAMMLGARGLQGAFGALLAPAALSLLAVMFTDATERAKAFGIYGAIAGGGGAVGLILG
                     GFLTEYLNWRWTFFVNIPFAIVAAVGAWLVIREPAHGRNRAPLDIPGVVLSTLGLVALV
                     YGFTRAESAGWSDAVTVGMFVASAVLLAAFVFVESRVKSPLLPLRVLLERNRGGVYLSL
                     GLAVIAMFGLFLFLTYYLQVVKGFSPVKTGFAFLPMIAGMITGSTQIGARLMTRVAPRL
                     LMGPGFLLAAVGMLLLTQLEVGSSYPALILPAQLLLGLGMGTAFMPAMSLATHGVNPAD
                     AGVASAMVNTSQQVGGAIGTALLNTIAASATTAYLTDHAAEAAAGGPAAKLVQAQAMVE
                     GYSSAIWWAVGILAASSAIALTLINTGRPGTGGPVASGDGEGAEAEAAVKIPVIAH"
     misc_feature    complement(5481..5495)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 19.4"
                     /tool="antismash"
     misc_feature    complement(5488..5497)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.04"
                     /tool="antismash"
     gene            complement(5542..6204)
                     /locus_tag="M444_RS15205"
                     /old_locus_tag="M444_15185"
     CDS             complement(5542..6204)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018515784.1"
                     /locus_tag="M444_RS15205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15185"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_008743005.1"
                     /transl_table=11
                     /translation="MKSPTTTPAAPALAVPKPRADAVRNRERILVAAREMLVESGVEAP
                     LDEIARRAGVGNATLYRHFPDRAALVHHVVLFVTDRVSAHAERALAEEPDAFAALRRFT
                     HAAADERIGALCPMLADDFDREHPELLASRDALEEAVQALLAAGQDGGLVRADIGVGDL
                     MMALSQLSRPLPGTACLQVDRFVHRHLGLFLDGLRAPARSELPGEAVTLDVLRRKTM"
     misc_feature    6361..6376
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.23"
                     /tool="antismash"
     misc_feature    complement(6384..6399)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 19.26"
                     /tool="antismash"
     gene            6516..7793
                     /locus_tag="M444_RS15210"
                     /old_locus_tag="M444_15190"
     CDS             6516..7793
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961134.1"
                     /locus_tag="M444_RS15210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15190"
                     /product="M6 family metalloprotease domain-containing
                     protein"
                     /protein_id="WP_037794632.1"
                     /transl_table=11
                     /translation="MPQTRRRIRRPRRTRACIGLTVLVLGVTATASTGISTRSHSAAGP
                     VAATAESALAPCRIAGTMGVQMSEGLPTPPGYSRSTGEVRALNLMIDFPDAKGEGTAAD
                     RLAEFFPQTSDWFRTSSYGRLTYRAEAPIRDWLRMPMPFAAYGIERGSAYEPGYRQLVE
                     HIVKAADPEVDFSRYDLVNILVTPNAGPSALDTVLSVTFSGNAEAPVADGVPLANTSFI
                     YSRQDDGSGSYRETGFRVLPHENGHVFGLPDLYTAEGGGAVGHWDIMSEDWGANNDLLG
                     WHKWKLGWLDSTQISCAAKSGVSDHTLSPLAVGGGMKLAFIPLSESAGYAVEVRTQAGN
                     DEAVCEPGVLIYKVDSDVDTGRGPVIVSDSANTSGGCTRRPNVHAELSDAPFRPGETFT
                     DEKAGISVSVVGELRNGSYQVRVTRP"
     gene            8056..9630
                     /locus_tag="M444_RS15215"
                     /old_locus_tag="M444_15195"
     CDS             8056..9630
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018088355.1"
                     /locus_tag="M444_RS15215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15195"
                     /product="glutamate synthase subunit beta"
                     /protein_id="WP_008743002.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-18, bitscore:
                     65.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDPFGFMKIPRRPVPARPVEARLGDWREVYAGQALLPLVSEQAN
                     RCMDCGLPFCHSGCPLGNLIPEWNAYAARGNWRAAYDRLHATNNFPEVTGRLCPAPCED
                     ACVLAINDDPVTIKNVEQAIADEGLRRGYLAPRPPERLSGKTVAVIGSGPAGLAAAQQL
                     TRAGHTVAVYERSDRLGGLLRYGIPEFKLEKEQVELRLGQMREEGTVFRTGVHVGGPGG
                     GPGGGSGGGSGGGSAGGAEGAGGAGAVSLDAAHLRRRFDAVVVAVGALEGRELPVPGRE
                     LSGIHQAMEYLTCANRVREGDYPASPVSAEGRHVIIVGGGDTGSDCLGTALRQGALSVV
                     QLDINPLPGETRPDHQPWPVYPKVYRISHAHEEARGRAGSDPRLFASATLRFEGDTGGR
                     VRGLRLTAVEPVARRPVGDSERVLPAELVLLALGFHGPERTGGLPDGLGLTWDARGTFA
                     RDAAFAALGGPRASGVFVAGDAGRGQSLVVWAIAEGRSAAAAVDRYLTGSTELPAPVSA
                     YDVPLTA"
     misc_feature    9686..9699
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.61"
                     /tool="antismash"
     gene            9790..9915
                     /locus_tag="M444_RS43755"
     CDS             9790..9915
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS43755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_008743001.1"
                     /transl_table=11
                     /translation="MTNVNDLFELDIIEIAAPVEDEQADAQAATGSWPFFCKTTI"
     gene            10001..13318
                     /locus_tag="M444_RS15220"
                     /old_locus_tag="M444_15200"
     CDS             10001..13318
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="M444_RS15220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15200"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_053065771.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.6e-198,
                     bitscore: 657.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.5e-16,
                     bitscore: 59.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.6e-31, bitscore:
                     107.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPAPHSGGDTPVPSAFRCSDTLLFRAAPRPPEPPGTAPDEPDE
                     DDVLDGQGAGGVTEADLRARLRRAAADARLREAVSLASPSLSRTLDAVLAGEPVRVKQL
                     RRAVRALARYRLRMSGRATPFGTMAGVAAIGFDEAPKAGWGERHRKAVRPDMGWLTEVV
                     ARLEREPAVLRPLRVTANDLCFVRGDRLVVPYLPAPGAGTRPAAQEVSVRASEVVLRLI
                     RRAATPVRFADLVPELVAAYPGVAAATVERLLVDLIGSEVLLTELRPPLDGADPLGHVL
                     ALLARGAEAGAEAEELPEGVTRTVAEMAAIQGELIAYAAAPLGSGLDARDSARRRMTAL
                     HPCDQLLQVDLGLDVDIRLPEAVRAEVEAAAEALWRLASARPGPAHLRQYHEDFLERYG
                     AGRSVPLKELLDPDGGLGGPAGYRLPATARTLRGTPADPRGPQDQDRLLTELAQEASLN
                     GEREIVLDDVLLERLAGGAADARSTPPPPLPPSFEILAQLLAATPEALADGDFRLVVTG
                     GARTAGAHAGRFGFVLGADDARVTELVRQVPGAAPGAVTAQLRFPPPRGATANVALVPR
                     RLEHTITLGAFADRSGGAEGADGTCGTDLGVSDLAVVADVHRLAVVAPRLGREVVPVVP
                     SMLATVWHAPNAARFLHEVTENGLPAWPRWRWGTADTLPYLPRVRRGRTVLSPARWRPT
                     DPALQDRATDPGAWERLFDAWRSRWRVPDRVESVSGDNRIALDLRRPFHRGLLRDEWLR
                     RPGGVLQELPTSCGYGTGWLAEGPDGDGAGPQGAGPQGPGRVNEIAFPLVRRERPTAAP
                     VRGSAVRPVAVVPAPRRVRTAYGPGSRWLYAKVYGSAERQDELLAHRLPSLLEGLPGAV
                     DRWFYLRYRDPDSHLRLRFHGDPAALTGDLLPRLAAWSDRLAEDGLGGRLVLDTYEPEL
                     ERYGGAAAAAAAERAFHADSVACLEQAALLERRELALDRTVLTALGYVDLACRIAGTTE
                     GVRHLIDRAAPPGAAEPARAAKDLARELVDPAGGWRHLRTLPGGPELLACWERRAPALA
                     AYGALLRELGAGPGPLDALLHMHHNRLTGIDRPAEERSFALAAVALRSRLDRTRAEA"
     aSDomain        10532..10810
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_M444_RS15220_Lanthipeptide_LanB_RRE.1
                     "
                     /evalue="5.90E-19"
                     /identifier="RREFam001.1"
                     /label="M444_RS15220"
                     /locus_tag="M444_RS15220"
                     /protein_end="270"
                     /protein_start="177"
                     /score="59.5"
                     /tool="antismash"
                     /translation="VTANDLCFVRGDRLVVPYLPAPGAGTRPAAQEVSVRASEVVLRLI
                     RRAATPVRFADLVPELVAAYPGVAAATVERLLVDLIGSEVLLTELRPP"
     gene            13315..14670
                     /locus_tag="M444_RS15225"
                     /old_locus_tag="M444_15205"
     CDS             13315..14670
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="M444_RS15225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15205"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_037797753.1"
                     /sec_met_domain="LANC_like (E-value: 4.7e-43, bitscore:
                     146.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAREHEALRARAAAAVTAVARRLADPAAADHPTPEVSPFRAASL
                     SDGAPGIALLHAELGAAAGGDPAHRDAALRWVRRAAALTALAGKTPAPGPQGLYGPLAA
                     LSFALHRTADGPAAHSAARSHLREQVAELASTRAAREERRLTEHPDPSSAPGSGSGFTT
                     FTAYDVISGQSGLGAHLLELGRPAEAALVRVLRALVGLSRPVRTHDRGLPGWWVALDGA
                     SYQPVAPARGHANLGMAHGMPGPLALLAIAWREGVRVPGQRAAVTDLAQWLLARRCADA
                     AGPWWPGQLSLGPAQPEPGRPSWCYGTPGIARALQLAGLALEVPQWQEAGVEALRAALA
                     RADLDGPARAGGTAEAGLCHGLAGLLQITWRAARDSGDPELAERVTQLAARLLELLDED
                     EPFGFAAAPGERPPEEHPGGFLTGAAGAALALDTFARDAEPATRWDRALLLA"
     gene            14736..15710
                     /locus_tag="M444_RS15230"
                     /old_locus_tag="M444_15210"
     CDS             14736..15710
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019619.4"
                     /locus_tag="M444_RS15230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15210"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_053065772.1"
                     /transl_table=11
                     /translation="MHRDELTRWVGDTDAFLDGHWRTAPAVFRPGTGSGTGTAAGPAAP
                     LSLEEIDAAVAGGLLRVPHLELARAGDPVHSSRYTRSRTVAGVTTPGYADPHRVRELLA
                     EGATLVLRNVEHWHPATRALTRRLEAELGRRVEAFFFVTPPGAQGLDLHRDDADVLLLQ
                     GTGSKHWTVRGGPAGPDWSPGEVADAGPALLSDTLRPGEVLYIPRGFAHEAVGGEGLSS
                     HLSLTIREAGTQQLFASLQRLLLDGLPLPARPLDDDALHAAAELLLERFRTRLPELTAE
                     ALLDHARRAQLAEGAVPGLGADPGIAALAARLDAPRDPAANAA"
     gene            15917..>16390
                     /locus_tag="M444_RS43070"
                     /pseudo=""
     CDS             15917..>16390
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="M444_RS43070"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAAKALIDRLVAGGSPTASAIGLGALVLASVLITAAGSYLLERTA
                     EGVVRTTRERLAARVLRLPVADMDRQRPGDLVARLTSDTGQLRAAAGQALAVCATSTLM
                     VLGGLTAMFLLDPVLAGATVGVIGTVCGIGSLTLPRIGRAARRSQQVTGELGAA"
     gene            16543..17214
                     /locus_tag="M444_RS43075"
     CDS             16543..17214
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="M444_RS43075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_235441313.1"
                     /transl_table=11
                     /translation="MSLDVPAGGLTALVGPSGAGKSTVFALLERFYEPASGRILLDGRD
                     VRDWPLTGLRATIGYVEQDAPVLSGTLRDNLLRSAPRASPEELRAVLALTRLDGLVERL
                     PAGLDTELGHRGTALSGGQRQRVAIARALLRRPRLLLLDEATSQLDAENERALRDAVAD
                     IARETTVVVIAHRLSTVTGARRIVVLEDGRARATGTHRELLASDELYGRLVRTQLLDHR
                     P"
     misc_feature    complement(17272..17287)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            17313..17537
                     /locus_tag="M444_RS15240"
                     /old_locus_tag="M444_15220"
     CDS             17313..17537
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="M444_RS15240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="M444_15220"
                     /product="hypothetical protein"
                     /protein_id="WP_037797755.1"
                     /transl_table=11
                     /translation="MTGTQKPTAAPPSRVRRAAAALVTGGLALGLVLGGAAAASADVAP
                     PPAPYVGTQLGDLAPSQDLVEGNWNSTGS"
     gene            complement(17592..20636)
                     /locus_tag="M444_RS15245"
                     /old_locus_tag="M444_15225"
     CDS             complement(17592..20636)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018891777.1"
                     /locus_tag="M444_RS15245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15225"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_047960605.1"
                     /transl_table=11
                     /translation="MTAGVRFELLGPMRAYRGDERLGTGTPQQQAMLAVLLLRSGHGAG
                     LGELIDALWGEEPPHAAVTTLRTYAWRWRKVLAEPGVLVSVGDGYRLVLEKPCLDVQEA
                     EELAARAAVERGAGRREAAAKLLREALGLWQGEPLAALPGPYAERQRSRLEELRLRLLE
                     DRLELDIEAGGEAAAVPDLRLLTSEHPLRERPVALLMRALCRTGRQADALNLFRTARQG
                     LISEIGLEPGPELLSLHQRILSGDQELAGAEDGGRRGGAVALSGGPAPDTAAAVTEGGG
                     GGGPEPEPEAPPVPAQTPSAPGDFTGRAALVRRLAEALTPAGDSGPALALISGMGGVGK
                     TALALHTADRVRDRFPDGQLYADLRGTDAHDPCDPGHVLVGFLAALGVTADALPADVEG
                     RAALFRSMTAGRRMLVVLDNARDAAQVRPLLPGPGRCAVLVTSRPRLAGLPARHQADLD
                     VFELPEALELFGRVIGRDRLDAEPETARELVATCGFLPLAVRIVAARLAARPSWTVALL
                     TARLADERRRLNELRVGDLAIAPVFELGYRQLSAEQARAFRVLACLDGPGIGLTSAAAA
                     LGADEFHVEEVLESLVDVAMLESPTPGRYRFHDLLRTFGRQCAGAGAGAGAGADAGVGV
                     DRAELAGALDGLLDHLLATACAAFRHAVPGDPVAAALGPLRARPLSFAGLEPARIWALT
                     ESETALALAAQIAACARPGHPAWRGRLRAAIDLLIALSPFHQDTRYGQLAPTGLLLAEA
                     AARHGDRKAEGRARFLCGTIALKDTRLAEAETEARLAVLACREAGDTVVLRQALNDLGL
                     VAQFLRRFDEAIACFDEAIALARELDHRSGEYATTVNAALARVRSGRAHEAVPACEAVL
                     PGLREMDDRHGICYALYVLGLALHATGRYEEAIARYGDCLAVAGPAGIRQRVAHARYRM
                     ADTLRAVGRHAEAQEQAEAALSLCRDLGSDRDSGHALVVLGRTLAERGRAEEARSRLLS
                     ASALFAKLGLPDVADVEELLAALPA"
     gene            complement(20671..21381)
                     /locus_tag="M444_RS15250"
                     /old_locus_tag="M444_15230"
     CDS             complement(20671..21381)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009190183.1"
                     /locus_tag="M444_RS15250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15230"
                     /product="contact-dependent growth inhibition system
                     immunity protein"
                     /protein_id="WP_008740648.1"
                     /transl_table=11
                     /translation="MTPSNDRFRELRELLDSYTVTGYAFDDTEDRRGVALSAYLRQAAR
                     DPARAAEAAAEIDDLIETGLFSDEIADDVDLLPHVNPPRGETVESCLAVIGRHLRQFLA
                     EPANPSQSPPRTAWEWRERFPGLQHLLAAYFHQDSSLEYSSYGEALDDYVSGASESDLR
                     QLADEIREFLILNESDQLLKKSAVTLGLAILPPRGVRLRQWLTDVRGIALQGTAPRGGS
                     GWGVQATRGGFGPS"
     misc_feature    21358..21371
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.04"
                     /tool="antismash"
     gene            complement(21454..22365)
                     /locus_tag="M444_RS15255"
                     /old_locus_tag="M444_15235"
     CDS             complement(21454..22365)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524910.1"
                     /locus_tag="M444_RS15255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15235"
                     /product="hypothetical protein"
                     /protein_id="WP_008740649.1"
                     /transl_table=11
                     /translation="MTYNLLTVDPVGPETVALALAGCLGFAVGDVDVADSDGDPDLRNW
                     DAPVSCEYRAVQGDVAWSLDVYAQERVADQPPESDLAAGFAKAAMTTVLFPAEEAPPSA
                     YWAVTPEGVLTRARLELSDDEPPLYAITAVEAPVPQLPGATVTRFAEIVREQRPDTPVA
                     WAFAASVEKVRQAASGLARLSLDDGTGSPVWTAKGNLMAWERVIAQMESGWAPSGWYPA
                     GLYRERLESRDELAGIGAHLPRDVTELLDGAVEQLDGRFAAATEDDPAGSLRRELTGGS
                     VEQAPHGWWWHRRPNPAPWEQA"
     misc_feature    22361..22376
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     misc_feature    complement(22451..22465)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.56"
                     /tool="antismash"
     gene            22921..23391
                     /locus_tag="M444_RS15260"
                     /old_locus_tag="M444_15240"
     CDS             22921..23391
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180500.1"
                     /locus_tag="M444_RS15260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="M444_15240"
                     /product="hypothetical protein"
                     /protein_id="WP_037792433.1"
                     /transl_table=11
                     /translation="MVWDEWEKAKVDVAGARQVSMRLNQVTSGPGGGQADLVVHQDDLG
                     EVGHEAFLLHGQLQKQADIAGAGADGSGSGSTMQAAASLKTASFSLGGELETTVSVWTS
                     QVKTVLQACAHISNHLDYSKKAHAADDEAIAASLRNRDGSAVSVSRIDEYLK"
     misc_feature    complement(23421..23435)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(23580..23595)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    complement(23626..23641)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.47"
                     /tool="antismash"
     misc_feature    24188..24206
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.5"
                     /tool="antismash"
     misc_feature    24588..24603
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.15"
                     /tool="antismash"
ORIGIN
        1 gggggcggcg atgccgccgc tggtgctgga cgacgaggag gccgtggcga tcgcggtggg
       61 cctgcgggcg ggcgccgggc acgcgatcga gggcgtggag gaggcgtccg tacgggcgct
      121 cgcgaagctg gagcaggtgc ttccggggcg gctgcggcac cgggtgggcg cgctgcagtc
      181 ggcgacggtc gcgctgaccc ggggcgacgg gccgagcgtg gacccgcgga cgctgacgac
      241 gatggcctcg gcggtggcgg ggccggagcg gctgcggttc gcgtaccggg cgcgcgacgg
      301 ggcgccctcg cggcggctgg tggagccgta ccggctggtg agcgcgcgca gccgctggta
      361 cctggtggcc tacgacctgg agcgggagga ctggcggacc ttccgggtcg accgggtcgc
      421 cgaggcgttc gcgacggggg cgaggttcac gccgcgcgag ccgccgatgg acgcggcggc
      481 gatggtggcg cgggccctgc ggggcggaca ggcgtacgag gtggacctgg cgttcgccgg
      541 ggtgacggcg caggagctgc cggcgtggct gcggggggcg gcggtggcgg aggagggcgg
      601 ctgccgggtg cggttcccca gcggggactc gccggagtgg ctggtcgcgc gggtggcgct
      661 gacgggcttg ccgttcaccg tgcgcgggcc ggacttcctc gtcgccgcgg ccgccgcgct
      721 ggccgcccgc ctcacggcgg cggcgggccc gggtgcgggg ccggggcccg agccgggtcc
      781 tgggtaggga gagagccccc ggcgcctggg ggggataggc accgggggct cgtacggggg
      841 gcgcgtcagg ccacggcgtc gaagccggtg tcgcgggcca tcttcttcag ctccagcagg
      901 gcgtgcttct cgatctggcg gatccgctcg cgggtcaggc cgtgctgctt gccgacctcc
      961 gtgagggtcc gctcgcggcc gtcgtcgatg ccgtagcgca tcttgatgat cgaggccgtg
     1021 cgctggtcga gcttgcccag caggtcctcc agctcctcgc tgcgcagcag cgagaggacg
     1081 gactgctccg gcgagatcgc cgaggtgtcc tccaggaggt caccgaactg cgtgtcgccg
     1141 tcgtcgtcga cggacatgtt gaggctgacc gggtcgcgcg cccagtccag gacgtcgccc
     1201 acgcgcttcg ccgtggtgtc cagctcggcg gcgatctccg tgtgctccgg gtcgcgcccg
     1261 tgctcgcggt tgaactcgcg ctgcacccgg cggatccggc cgagctcctc gaccaggtgg
     1321 acggggaggc ggatcgtccg ggactggtcg gcgatggagc gggtgatggc ctggcggatc
     1381 caccacgtcg cgtacgtgga gaacttgaag cccttggcgt agtcgaactt ctcgacggcc
     1441 cgcaccaggc ccgcgttgcc ctcctggatc aggtccagca ggggcagacc gctgcgcggg
     1501 tagcggcggg cgaccgcgac gaccaggcgc aggttggagc ggatgaagac ttccttggcc
     1561 cgctccccct cggcggcgag cgcttcgagc tcctcgcgcg cgggcgcctc gccctcgcgc
     1621 tccgcctcgc cgtcgaggat ctgccgggcg tacacgcccg cctcgatgat ctgggagagc
     1681 tctacttcct tggcggcgtc gagcagcggg gtgcgcgcga tctcgtccag gtacatgccg
     1741 accaggtcgc ggtcggcgat ctccccgccc acagcgcggg cgctgctgct ggactgacga
     1801 cgggcgacgg cgcgggttgc catgcgtgct cccttgcgaa gtgttcggtc gcggtgcgtg
     1861 cggctggtgt ctgctgctgg tgtcttcgga cactctcccg agtgcccgct tccgaaggaa
     1921 acaacgactg gaatcgggac agaattcccg cgtcggtccc tcgttttcga gatcttgcag
     1981 tatgctgccc cgccgacccc cgcccataac ggggaccgta gcccggaaat ctcgaagagg
     2041 tgcaggtcag gccaggtttc ccgggggacg cggcgcacct cgtggagttt tacaacttcc
     2101 acaacgttga gaccgcgatc acacgcgcgg cccaccgccc ctgcctgcac tccgccccgg
     2161 aagacgaccc cggccgccct ccggttgcct ggactggcga tcgactaccc ggaaaaccag
     2221 catccatccc ttttcgcccg accccgcacc acccgtccgg gtgagccgta ggcatatccc
     2281 accggcatgg gcggcgggct cctagcctcg gagggtcgct tgtgccgcac agtcggcggc
     2341 gcccacactt gaggaggtgc tacacccatg accgctctcg cacacgagat gttggaggcc
     2401 cccatgccga aggccgcgac tcctccgtca gaactggacg aggccctgtg gcaggcatgg
     2461 aaggccatgg aactccccga gggcttccac gccgagatca tcgaggggtt catcgaggtg
     2521 tcaccgaccg ggcgcttgcc ccacagcaag atcaccaatg ggctgcggcg aaccctggac
     2581 agattcctgg agcggggcga gttcgcggcc tttcaggaca ccaacgtcat ccacgggcag
     2641 aaggtctgga tccccgacgt cctgatcgca cccgaggatg tggacatcca cggcacagag
     2701 gacgggatcg gcatcagggc cgaggccgtg cggctcgtcg tcgaggtcgt ctcgcccggc
     2761 agcgacagca tcactcgcga ccggacccgc aagcgccgcg cgtacgcccg cgccgggatt
     2821 ccggtctacg tgctcatcga cgactacgac gacggcggca ccgtcaccgt cctcagcagg
     2881 ccggaccggg agaaggcgat ctacggcgac gaggtccggg ccgcgtacgg ggccgccgtc
     2941 accgtgcccg agggacccgc gaaggggttc gtcatcggcg aggacatcac cggggccggg
     3001 cagccgcgga ggggctaggc gcggtcagcc gaactggagg gagcgcttgg acaggcccag
     3061 ccagaagccg tccaccgggg tgcggggggc ggcgaggtcg gggccggccg cgccgagggt
     3121 gacgaagagc ggggcgaagt gttccgtacg ggggtgggcc aggcggccgg ccggggactt
     3181 gcgctcgaag tccagcaggg cgtccacgtc cgaggcggcc agcgcctcgc ggccccacgc
     3241 gtcgaactcc gccgaccacg cgggaacgcc cgggccccgg tggcgcagcg ccgccaggtt
     3301 gtgggtgaag aagccgctcc cgacgatcag gacgccctcg tcgcgcagcg gggccagctt
     3361 gcggccgatg cccatcaggc gggccgggtc cagcgtgggc agggagatct gcagcaccgg
     3421 gacgtccgcc tgcgggtaca tctccaccag ggggacgtac gccccgtggt cgaggccgcg
     3481 gtccgggacg tcctggaccg gggtgccggg ggcccgcagc agtccccgta ccgacgcggc
     3541 cagcccgggg gcgcccgggg cgtcgtagcg cacccggtag tagtgctcgg ggaagccccg
     3601 gaagtcgtgg aggagcggga cgcgctcggt ggcgccgagg gcgagcgggg cctcttccca
     3661 gtgcgcggag accatcagga tcgcccgggg tcgcggcagg tccgccgacc aggcggcgag
     3721 ttcgcccggc cagagcgggt cgtcggccag cgggggcgcg ccgtggctca ggtacaggac
     3781 cggtatgcgg gtggtggcgg acacgggggc tcctccggcg gtggggcggc gtcacgggga
     3841 aagaccgacc ccgcttcgtt caaatttgaa cgaagcgggg tcgtcagtca ttcccggacg
     3901 cgcggcggcg ccgtcagtgg gcgatcaccg ggatcttgac cgcggcctcg gcctcggcgc
     3961 cctcgccgtc accggaggcc accgggccgc ccgtgcccgg acgccccgtg ttgatcaggg
     4021 tgagggcgat ggccgagctg gcggccagga tgccgacggc ccaccagatg gcggaggagt
     4081 agccctccac catggcctgc gcctggacca gcttcgcggc cgggccgccc gccgcggcct
     4141 cggccgcgtg gtcggtcagg tacgcggtcg tcgccgaggc ggcgatcgtg ttcagcaggg
     4201 cggtgccgat cgcgccgccc acctgctgcg aggtgttgac catggcggag gccacaccgg
     4261 cgtcggccgg gttcaccccg tgcgtggcca gggacatggc cggcatgaag gccgtaccca
     4321 tgccgaggcc cagcagcagc tgcgccggca ggatcagcgc cgggtaggag gatccgacct
     4381 ccagctgggt cagcagcagc atgccgacgg cggcgagcag gaagcccggg cccatcagca
     4441 gccgcggcgc gacccgggtc atcagccggg cgccgatctg ggtggagccc gtgatcatgc
     4501 ccgcgatcat cggcaggaag gcgaagccgg tcttgacggg cgagaagccc ttcacgacct
     4561 ggaggtagta cgtcaggaag aggaacaggc cgaacatcgc gatgacggcc agacccagcg
     4621 agaggtagac cccgccacgg ttgcgctcca gcaggacgcg cagcggcagc agcggggact
     4681 tcacgcggga ctcgacgaac acaaacgccg cgagcagcac ggcggaggcg acgaacatgc
     4741 ccaccgtgac cgcgtcggac cagccggccg actcggcgcg ggtgaagccg tagaccagcg
     4801 cgacgaggcc gagcgtggac aggaccacgc cagggatgtc cagcggcgcg cggttgcggc
     4861 cgtgggcggg ctcacggatg accagccagg cacccacggc cgcgacgatc gcgaacggga
     4921 tgttgacgaa gaaggtccag cgccagttca ggtactcggt gaggaaaccg ccgaggatca
     4981 ggccgaccgc gccaccgcca ccggcgatcg cgccgtagat gccgaaggcc ttggcgcgct
     5041 ccgtggcgtc ggtgaacatg acggccagca gggagagcgc ggccggggcg agcagcgcgc
     5101 cgaaggcgcc ctggaggcca cgggcaccga gcatcatcgc ctcgccgttg gctgcgccgc
     5161 cgagcgcgga ggccagggcg aagccgatga ggccgacgat gaaggcgttc ttgcggcccc
     5221 acttgtcggc gatgcggccg ccgaagagga gcagtccgcc gaaggccagc gcgtacgcgg
     5281 tgatgaccca ctggcggttg ccgtccgaga tgcccagatc actctgggcg gagggcaggg
     5341 cgatgttcac gatggtcgcg tcgagcacga ccatcagctg ggccagggct atgaagacga
     5401 gtgccttcca gcggctgggg tcggcagcca gcggcgaggt cgcggctgtt tttggcatgg
     5461 gaatacccac tcactgtgcg gaatgactga aaaatcaggt ttagggaagg ttttcgacgc
     5521 tagcgggcgc gacccggggc gtcacatggt tttccgtctc aggacgtcga gcgtgaccgc
     5581 ctcgccgggc agttccgagc gggccggggc ccgcaacccg tcgaggaaca gcccgaggtg
     5641 acggtgtacg aagcggtcca cctgcaggca cgccgtgccg ggcagcgggc ggctgagctg
     5701 ggacagcgcc atcatcaggt cgccgacgcc gatgtcggcg cggaccagcc cgccgtcctg
     5761 gccggcggcc agcagcgcct ggaccgcctc ttccaaggcg tcgcgggacg cgaggagttc
     5821 ggggtgctcg cggtcgaagt cgtcggcgag catggggcac agggcaccga tccgctcgtc
     5881 cgcggcggcg tgcgtgaagc ggcgcagcgc ggcgaaggcg tcgggctcct cggccagggc
     5941 gcgctcggcg tgggcgctga cccggtccgt cacgaagagc acgacgtggt ggacgagggc
     6001 cgcccggtcg gggaagtgcc ggtagagggt ggcgttgccg accccggccc ggcgggcgat
     6061 ctcgtcgagc ggggcctcga caccggactc cacgagcatc tcgcgggccg cgaccaggat
     6121 ccgctcgcgg ttgcggacgg cgtcggcgcg cggcttggga acggcgaggg caggagccgc
     6181 cggtgtggtg gtggggctct tcattccgcg ggcctcctgg ctctgggtcg ggctctggtc
     6241 gggctctggc gccgggtcgg gctctggcgc tgatgtgcgt acggtccgcg tccgggcggt
     6301 cggccccaaa cggggagccg gtccccggtt cgcgggactc tgatgcaaac ggggattcca
     6361 tccccggtta tttcaccctc ccgtgtgagc cggctcacag ctcatttccc gttcggcccc
     6421 actcgacagg cgggcgcgtc gcagccgacg gagggtgagc ccacggagtg cagaccgggc
     6481 ccggccggct gccgcggacc ccgaaggcgc tctccatgcc gcagacccgc cgccggatac
     6541 gcagaccacg ccgcacccgc gcgtgcatcg gcctcaccgt gctcgtcctc ggcgtcaccg
     6601 cgaccgcgag caccggaata tccacccgga gccactccgc cgcgggaccg gtggcggcga
     6661 ccgccgaatc ggcgctcgcg ccctgccgga tcgccggcac gatgggcgtc cagatgtccg
     6721 agggcctgcc gaccccgccc gggtactccc ggtccaccgg cgaggtccgg gcactgaacc
     6781 tgatgatcga cttcccggac gccaagggcg agggcacggc cgccgaccgg ctggccgagt
     6841 tcttccccca gacctccgac tggttcagga ccagctccta cgggcggctg acctaccggg
     6901 ccgaggcccc catacgggac tggctgcgga tgccgatgcc gttcgcggcg tacgggatcg
     6961 agcgcgggtc cgcctacgag ccgggctacc ggcagctcgt cgagcacatc gtgaaggccg
     7021 ccgaccccga ggtggacttc agccggtacg acctggtcaa catcctcgtc acgccgaacg
     7081 ccgggccctc cgcgctggac accgtgctgt cggtgacctt ctccgggaac gccgaggcgc
     7141 ccgtcgccga cggggtgccg ctcgccaaca cgtccttcat ctacagccgg caggacgacg
     7201 gctcgggctc ctaccgggag accggcttcc gggtgctccc ccacgagaac gggcacgtct
     7261 tcggactgcc ggacctgtac acggccgagg gcggcggcgc ggtcgggcac tgggacatca
     7321 tgagcgagga ctggggcgcc aacaacgacc tgctgggctg gcacaagtgg aagctgggct
     7381 ggctggacag cacgcagatc agctgcgccg cgaagtcggg cgtcagcgac cacaccctgt
     7441 cgccgctggc ggtggggggc ggcatgaagc tggccttcat accgctgtcg gagagcgccg
     7501 ggtacgcggt ggaggtgcgg acccaggccg ggaacgacga ggccgtgtgc gagccgggcg
     7561 tgctcatcta caaggtggac tcggacgtgg acaccgggcg cggcccggtg atcgtgtcgg
     7621 acagcgcgaa caccagcggc ggctgtacgc ggcggcccaa cgtgcacgcg gaactgtcgg
     7681 acgccccgtt caggccgggc gagaccttca ccgacgagaa ggcgggcatc agcgtctcgg
     7741 tcgtcggcga gctgcgcaac gggagctacc aggtccgggt cacccggccg tgacgcggag
     7801 cccctcccgg gctcccggga acgcggacgg agggcaggtg cgccacgtac accgtgacgg
     7861 ggccccgcgg ggtctcggcg gcggcgcgca gggcgcgggg cagcggcatg ccccgcggcg
     7921 gcggtgaaac ggccccggcc ctggtcgcgc gtcacgttcc ggatcatgcc ctgtggacgc
     7981 cccgcgccgg gacgacggga gatggcgggg gtgtcggcgt agcctgaggt ggcggcgcga
     8041 agagggaggc ggcgcatgac cgatccgttc gggttcatga agatcccgcg gcgtccggtg
     8101 cccgcccgcc ccgtcgaggc gcggctgggg gactggcgcg aggtgtacgc gggtcaggcg
     8161 ctgctgccgc tggtctccga gcaggccaac cggtgcatgg actgcggtct gcccttctgc
     8221 cacagcggct gcccgctggg gaacctgatc cccgagtgga acgcgtacgc ggcccgcggg
     8281 aactggcgcg ccgcgtacga ccggctgcac gccaccaaca acttccccga ggtgaccggc
     8341 cggctctgcc cggccccctg cgaggacgcc tgcgtgctgg cgatcaacga cgacccggtg
     8401 acgatcaaga acgtcgagca ggccatcgcc gacgagggcc tgcgccgcgg ctacctcgcg
     8461 ccgcgccccc cggagcggct cagcggcaag accgtggccg tcatcggctc cggcccggcc
     8521 ggactcgccg cggcgcagca gctgacgcgc gccgggcaca ccgtcgccgt gtacgagcgc
     8581 tccgaccggc tcggcgggct gctgcgctac gggataccgg agttcaagct ggagaaggag
     8641 caggtggagc tgcggctcgg ccagatgcgg gaggagggga cggtcttccg tacgggggtg
     8701 cacgtcggcg gcccgggagg cggcccggga ggcggctcgg gaggcggctc gggaggcggc
     8761 tcggcgggcg gagcagaagg agcgggcggc gcgggagccg tgtccctcga cgcggcgcac
     8821 ctgcggcggc ggttcgacgc cgtcgtcgtc gcggtcggcg ccctggaggg ccgggagctg
     8881 cccgtccccg gccgcgagct gtccggcatc caccaggcga tggagtacct gacctgcgcc
     8941 aaccgggtcc gcgagggcga ctacccggcg tccccggtca gcgccgaggg ccggcacgtg
     9001 atcatcgtcg gcggcgggga caccggctcc gactgcctgg gcaccgcgct gcggcagggc
     9061 gcgctctcgg tggtccagct ggacatcaac ccgctgcccg gcgagacccg gccggatcac
     9121 cagccctggc cggtgtaccc gaaggtctac cggatctccc acgcccacga ggaggcgcgc
     9181 ggccgggccg gcagcgaccc ccggctcttc gccagcgcca ccctgcgctt cgagggcgac
     9241 accgggggcc gcgtccgggg cctgcgcctg accgccgtgg aaccggtggc ccggcggccg
     9301 gtcggcgaca gcgagcgcgt cctgccggcc gagctggtgc tgctggcgct cggtttccac
     9361 ggcccggagc ggaccggggg cctgcccgac gggctcggcc tgacctggga cgcccgcggc
     9421 accttcgccc gcgacgcggc cttcgccgcc ctcggcggtc cgcgggcctc cggggtcttc
     9481 gtcgcggggg acgcggggcg ggggcagtcg ctggtggtgt gggccatcgc cgagggccgg
     9541 tcggcggccg ccgccgtcga ccgctacctg accggctcga ccgaactgcc cgcgccggtc
     9601 tcggcgtacg acgttccgct gacggcctga cgggaggccc tggcgggcgg gctccggggg
     9661 cgttgatcgg gcgtcgatcc cgcgtcgaac acacgttgct ccgggcttcg tacggtcttc
     9721 acatgccgcc ggggacaagc ccggaggacg ccgccggaga cgggggcgca ccgcaatcaa
     9781 ggagacgtca tgaccaacgt caacgacctg ttcgagctgg acatcatcga gatcgccgcc
     9841 cccgtcgagg acgagcaggc cgacgcccag gccgcgaccg gctcctggcc gttcttctgc
     9901 aagaccacca tctgagggtc ggtcacgcag aagcactagt agaggcggcc ctcccccggg
     9961 ccgcctctct tgttcccccg ctctttcctg gaggctcccc gtggcggcac ccgctcccca
    10021 ctcgggcggt gacacccccg ttccgtcggc gttccgctgc tcggacaccc tgctgttccg
    10081 ggccgcgccc cggccgccgg agccgcccgg caccgcgccc gacgaacccg acgaggacga
    10141 cgtgctcgac gggcagggcg ccggtggcgt cacggaggcg gacctgcggg cccggctccg
    10201 ccgcgccgcg gccgacgccc ggctccggga ggcggtctcg ctggcgagcc cgtcactgag
    10261 ccgcaccctc gacgcggtgc tcgccgggga gccggtccgc gtcaagcaac tgcgccgcgc
    10321 ggtacgggcg ctggcccgct accggctgcg gatgtccggc cgggccacgc ccttcggcac
    10381 catggccggg gtcgccgcca tcggcttcga cgaggcgccc aaggccggct ggggcgagcg
    10441 gcaccgcaag gccgtccggc ccgacatggg ctggctgacc gaggtggtgg cccgcctgga
    10501 gcgcgagccc gcagtcctgc ggccgctgcg cgtcaccgcc aacgacctgt gcttcgtacg
    10561 gggcgaccgg ctggtcgtcc cgtacctgcc cgcgcccgga gcgggcaccc ggccggccgc
    10621 ccaggaggtc tcggtgcggg cgagcgaggt ggtgctgcgc ctgatccggc gcgccgccac
    10681 ccccgtccgg ttcgccgacc tggtccccga actcgtcgcc gcctaccccg gggtggccgc
    10741 cgcgaccgtg gagcggctcc tcgtcgacct catcggctcc gaggtgctcc tgacggagct
    10801 gcggccgccg ctggacggtg ccgatccgct cggccacgta ctggccctgc tggcgcgggg
    10861 cgcggaggcg ggagcggagg cggaggagct gcccgaaggg gtgacccgga ccgtcgccga
    10921 aatggccgcg atccagggcg agttgatcgc gtacgcggcg gccccgctgg gttccgggct
    10981 cgacgcccgg gactccgcgc gccgccggat gaccgccctg cacccctgcg accagctgct
    11041 ccaggtggat ctgggactcg acgtggacat ccggctgccg gaggccgtgc gcgccgaggt
    11101 ggaagcggcc gccgaggcgc tgtggcggct ggcctccgcc cggccgggcc cggcccatct
    11161 gcgccagtac cacgaggact tcctcgaacg ctatggcgcc gggcgctccg taccgctcaa
    11221 ggaactcctc gatccggacg gcggcctcgg cggtcccgcc gggtaccggc tgcccgccac
    11281 cgcgcggacc ctgcgcggca cgccggcgga cccgcgcggg ccgcaggacc aggaccggct
    11341 gctgaccgag ctcgcgcagg aggcctccct caacggggag cgggagatcg tgctggacga
    11401 cgtactgctg gagcggctgg ccgggggcgc cgcggacgcg cgctcaacgc ccccgccgcc
    11461 cctgccgccg tcgttcgaga tcctcgcgca gctgctcgcc gccacccccg aggcgctcgc
    11521 cgacggggac ttccggctgg tcgtcaccgg tggggcgcgc accgcggggg cgcacgccgg
    11581 gcggttcggg ttcgtgctcg gcgccgacga cgcccgggtc accgagctgg tccggcaggt
    11641 gccgggggcc gcgccgggcg ccgtcaccgc gcagctgagg ttcccgccgc cgcgcggcgc
    11701 gacggccaac gtggcgctgg tgccgcggcg cctggaacac accatcaccc tgggcgcgtt
    11761 cgccgaccgc tccggcgggg ccgagggcgc cgacggcaca tgcggcaccg acctcggcgt
    11821 gtccgatctg gccgtcgtcg ccgacgtgca ccggctcgcg gtggtcgcgc cccggctggg
    11881 ccgcgaggtc gtccccgtcg tccccagcat gctcgcgacg gtctggcacg cgccgaacgc
    11941 cgcccgcttc ctgcacgagg tgaccgagaa cgggctcccg gcatggccgc gctggcgctg
    12001 gggcaccgcc gacaccctgc cgtacctgcc gagggtccgg cgcggccgta ccgtgctctc
    12061 cccggcccgc tggcgcccga cggacccggc gctccaggac cgggccaccg acccgggcgc
    12121 gtgggagcgg ctcttcgacg cctggcgctc ccgctggcgg gtgcccgacc gggtggagag
    12181 cgtcagcggc gacaaccgca tcgccctcga cctgcgccgg cccttccacc gggggctgct
    12241 gcgcgacgag tggctgcggc ggcccggcgg cgtcctccag gagctgccga cgagctgcgg
    12301 gtacgggacg ggctggctgg ccgagggccc ggacggcgac ggggcggggc cgcagggggc
    12361 ggggccgcag ggtccgggcc gggtcaacga gatcgcgttc ccgctggtcc ggcgggagcg
    12421 gccgacggcc gcgccggtac ggggttccgc cgtccggccg gtggccgtcg tgcccgcgcc
    12481 ccggcgcgtc cgtaccgcgt acggtcccgg ctcgcggtgg ctttacgcca aggtgtacgg
    12541 ctcggccgag cgccaggacg agctcctcgc ccaccggctg ccgagcctgc tggaggggct
    12601 gcccggcgcg gtcgaccgct ggttctacct gcgctaccgc gatcccgact cccacctgcg
    12661 gctgcgcttc cacggcgacc cggccgcgct caccggggac ctgctgcccc gcctcgccgc
    12721 ctggtcggac cggctcgccg aagacgggct cgggggccgg ctggtcctgg acacctacga
    12781 gcccgaactc gaacgctacg ggggcgccgc cgcggcggcc gccgccgaac gcgccttcca
    12841 cgccgacagc gtcgcctgcc tggagcaggc cgcgctgctg gagcgccgcg aactggcgct
    12901 ggaccgcacc gtgctgacgg ccctcgggta cgtcgacctg gcctgccgga tcgccggcac
    12961 cacggagggc gtccggcacc tgatcgaccg cgcggcgccg ccgggggccg ccgagccggc
    13021 ccgcgccgcc aaggacctgg cccgggagct ggtcgacccg gccggcggct ggcggcacct
    13081 gcgcacgctg cccggcggcc cggagctgct cgcctgctgg gagcggcgcg cgccggcgct
    13141 ggccgcgtac ggggcgctgc tgcgggaact cggcgccggt ccgggcccgt tggatgcgct
    13201 gctgcacatg caccacaacc gcctcacggg catcgaccgc cccgcggagg agcgctcctt
    13261 cgccctggcc gccgtggcgc tgcgcagccg cctggaccgt acgagggccg aagcatgagc
    13321 gcgcgggagc acgaggcgct gcgcgcgcgg gccgccgccg ccgtgacggc cgtcgcccgg
    13381 cgcctcgcgg accccgccgc cgcggaccac ccgactccgg aggtctcccc gttccgcgcg
    13441 gccagcctca gcgacggcgc cccgggcatc gccctgctcc acgcggaact cggcgctgcg
    13501 gcggggggcg atccggcgca ccgggacgcc gcgctgcggt gggtgcggcg agccgccgcg
    13561 ctcaccgcgc tcgccgggaa gaccccggcc cccgggccgc aggggctgta cgggccgctg
    13621 gccgcgctgt cgttcgccct gcaccggacg gccgacggcc cggccgcgca cagcgccgcc
    13681 cgctcccacc tgcgggaaca ggtagcggaa ctcgcctcca cccgcgccgc ccgcgaagaa
    13741 cgccgcctca ccgaacaccc cgacccgagc tccgccccgg gctccgggtc cggctttacg
    13801 accttcaccg cgtacgacgt gatcagtggg cagagcgggc ttggtgcgca tctgctggag
    13861 ctcgggcgtc cggccgaggc cgccctcgtg cgggtgctgc gggcgctggt cgggctcagc
    13921 cggcccgtcc gtacccacga ccgcggactg cccggctggt gggtggcgct ggacggcgcc
    13981 tcgtaccagc cggtggcccc ggcgcgcggg cacgcgaacc tgggcatggc ccacggcatg
    14041 cccggcccgc tggcgctgct ggccatcgcc tggcgggaag gggtgcgggt gccggggcag
    14101 cgggccgccg tcaccgacct cgcgcagtgg ctcctcgcgc ggcggtgcgc ggacgccgcg
    14161 ggcccctggt ggcccggcca gctgtcgctg gggcccgcgc agcccgaacc cggccgcccc
    14221 tcctggtgct acggcacccc cggcatcgcc cgggccctcc agctggcggg cctggccctg
    14281 gaggtgccgc agtggcagga ggccggcgtc gaggcgctgc gggccgcgct ggcccgcgcc
    14341 gatctggacg gaccggcccg ggccggcggg acggccgaag ccgggctctg ccacgggctg
    14401 gcggggctgc tccagatcac ctggcgcgcc gcccgcgaca gcggcgaccc cgaactcgcc
    14461 gagcgggtaa cgcagctggc ggcccggctg ctggaactcc tcgacgagga cgagccgttc
    14521 ggcttcgccg ccgcgcccgg cgaacgtccg cccgaggaac atccgggcgg cttcctcacc
    14581 ggcgcggccg gggcggcgct cgccctggac accttcgccc gcgacgccga gccggccacg
    14641 cgctgggacc gtgcgctgct gctggcctga cctgcccggc cccggccccg cccccggcca
    14701 tctgaccgac gcactcgaca cagagaagag accccatgca ccgggacgaa ctcacccgct
    14761 gggtgggcga cacggacgcc ttcctcgacg gccactggcg gaccgcgccc gccgtcttcc
    14821 ggcccggcac cggaagcggc accggcaccg ccgccggacc cgccgccccg ctctccctgg
    14881 aggagatcga cgccgccgtc gcgggcggcc tgctgcgcgt gccgcacctc gaactcgccc
    14941 gcgccggcga cccggtgcac tcctcccgct acacccggtc ccgcaccgtc gccggagtca
    15001 ccacccccgg ctacgccgat ccgcaccggg tacgggagct gctcgccgag ggcgccacgc
    15061 tggtgctgcg caacgtcgag cactggcacc cggccacgcg ggcgctgacc cgccgcctgg
    15121 aggccgaact cggccgccgc gtcgaggcgt tcttcttcgt caccccgccg ggggcacagg
    15181 gcctggacct gcaccgcgac gacgccgacg tactgctgct ccagggcacc ggcagcaagc
    15241 actggacggt gcgcggcggc cccgccggcc ccgactggag tcccggcgag gtcgccgacg
    15301 ccggcccggc cctgctctcg gacaccctgc gccccgggga ggtgctgtac atcccgcggg
    15361 gcttcgccca cgaggcggtg ggcggtgagg ggctctcctc gcacctctcg ctcacgatcc
    15421 gggaggcggg cacgcagcag ctgttcgcct cgttgcagcg gctgctgctg gacgggctgc
    15481 cgctgccggc ccgcccgctg gacgacgacg ccctgcacgc ggccgccgag ctgctgctgg
    15541 agcggttccg gacacggctg ccggagctga ccgccgaggc cctgctggac cacgcgcgcc
    15601 gggcgcagct cgccgagggc gcggtgcccg ggctcggcgc ggacccgggc atcgcggcgc
    15661 tggccgcacg gctcgacgcg ccccgggacc cggcggcgaa cgccgcgtga ccgacgccgc
    15721 cgaggccctg ctgggcacac cgcaggcggg gcgcgcgaca cccgcgcccg ccctcgtacc
    15781 caagcccgaa cccacacccg ccgcgccctc cgggctgcgg ctgctgctga cgcggcatct
    15841 gcggccccac cgggggcggc tcgtggcggg ggccgggctc gggctggccg gcgggctcgc
    15901 cgggctcgcc gagccgatgg ccgccaaggc cctcatcgac cggctggtcg cgggcggctc
    15961 gcccaccgcc tccgcgatcg ggctcggcgc cctggtgctg gcctccgtac tgatcacggc
    16021 ggccggctcg tacctgctgg agcggaccgc cgagggcgtg gtccgcacca cccgcgagcg
    16081 gctcgccgcc cgcgtgctgc ggctgccggt ggccgacatg gaccgccagc gccccggcga
    16141 cctggtcgcc cggctgacct ccgacaccgg ccagctgcgg gcggcggccg ggcaggccct
    16201 cgcggtctgc gccacctcca cgctgatggt gctcgggggc ctcaccgcga tgttcctgct
    16261 ggacccggtg ctggcgggcg ccaccgtcgg cgtgatcggc accgtctgcg ggatcggttc
    16321 gctcaccctg ccccggatcg gccgggcggc ccgccgctcc cagcaggtca ccggtgagct
    16381 cggggccgcg ctggaacgcg cgctcggcgc cttccgtacc gtcaaggcga acggcctgga
    16441 gcggcgggag accccgccgc agtcccggcc gcgccgctcg cgctggagct gcgcggcgtc
    16501 cgtttcgggt acccggggcg ggacaccacc gtcctcgacg gcctgtcgct cgacgtcccg
    16561 gcgggcgggc tcaccgcgct cgtcggcccc tccggcgccg gcaagagcac cgtgttcgcg
    16621 ctgctggagc ggttctacga gcccgcctcg ggccggatcc tgctcgacgg ccgcgacgta
    16681 cgggactggc cgctgaccgg cctgcgcgcc accatcgggt acgtggagca ggacgccccg
    16741 gtgctgtccg gcaccctgcg ggacaacctg ctgcggtccg cgccccgggc ctcgcccgag
    16801 gagctgcggg cggtcctcgc gctgacccgg ctggacgggc tcgtggagcg gctgcccgcc
    16861 ggcctggaca ccgaactcgg gcaccgcggc acggccctgt cgggcggtca gcgccagcgc
    16921 gtggccatcg cgcgcgccct gctgcgccgg cccaggctgc tgctgctcga cgaggcgacc
    16981 tcgcagctgg acgccgagaa cgagcgggcg ctgcgcgacg cggtcgcgga catcgcccgg
    17041 gagacgacgg tcgtggtgat cgcgcaccgg ctgtccaccg tcaccggcgc ccgccggatc
    17101 gtggtcctgg aggacgggcg ggcgcgcgcg accgggacgc accgggagct gctcgcctcg
    17161 gacgagctgt acgggcggct ggtgcgcacc cagctgctgg accaccgccc gtgaccctgg
    17221 actccgagac gttgatccgg cgtcgatccg ggattgaccc acgcttcgga tactggtccc
    17281 gaccacgctc ttccgacgaa ggactgatcc acatgaccgg tacgcagaag cccaccgccg
    17341 cgcccccctc ccgcgtccgg cgggccgccg ccgccctcgt gacgggcggc ctggccctgg
    17401 gtctcgtact gggcggggcc gccgcggcga gcgccgacgt ggcgccgccg cccgcgccgt
    17461 acgtcggcac ccagctcggc gacctggcac cctcgcagga cctcgtggag gggaactgga
    17521 acagcaccgg ctcctgagca ccggggctcc tgggcgccgg gccgcggcgc ggggcggggc
    17581 ggggcggcgg ctcaggcggg cagcgccgcc aggagttcct cgacgtccgc cacgtccggc
    17641 aggccgagct tggcgaacag cgccgacgcg ctgagcagcc ggctccgggc ctcctcggcg
    17701 cggccgcgct cggccagcgt ccggccgagc accaccagcg cgtgcccgct gtcccggtcg
    17761 gagccgaggt cgcggcacag cgacagcgcc gcctccgcct gctcctgggc ctccgcgtgc
    17821 cggcccaccg cgcgcagcgt gtcggccatc cggtagcggg cgtgcgccac ccgctggcgg
    17881 atcccggcgg gcccggcgac ggccaggcag tccccgtacc gcgcgatcgc ctcctcgtac
    17941 cggcccgtgg cgtgcagcgc gagcccgagg acgtacaggg cgtaacagat gccgtgccgg
    18001 tcgtccatct cccgcagccc cggcagtacg gcctcgcagg ccgggacggc ctcgtgggcg
    18061 cggccgctgc ggacccgggc gagggccgcg ttgacggtgg tggcgtactc gccggagcgg
    18121 tggtcgagtt cccgggcgag cgcgatggcc tcgtcgaagc acgcgatggc ctcgtcgaag
    18181 cggcgcagga actgggcgac caggccgagg tcgttgaggg cctggcgcag caccacggtg
    18241 tcgccggcct cgcggcaggc cagtacggcg agccgcgcct cggtctcggc ctccgcgagc
    18301 cgggtgtcct tgagcgcgat cgtcccgcac aggaagcggg cccgcccctc ggccttgcgg
    18361 tcgccgtgcc gggcggcggc ctcggcgagg agcaggccgg tgggggcgag ctggccgtag
    18421 cgggtgtcct ggtggaaggg gctcagggcg atcagcaggt cgatggcggc gcgcagccgc
    18481 ccgcgccagg cggggtggcc gggccgcgcg caggccgcga tctgcgcggc cagcgcgagg
    18541 gcggtctccg attcggtcag cgcccagatc cgggcgggct ccagcccggc gaaggacagc
    18601 ggtcgcgcgc gcagcgggcc gagcgccgcc gcgacggggt cgccgggtac ggcgtgccgg
    18661 aacgcggcgc aggcggtggc gaggaggtgg tcgaggagcc cgtcgagggc gcccgccagc
    18721 tcggcccggt cgacgccgac gccggcgtcg gcaccggcac cggcaccggc tcccgctccc
    18781 gcgcattggc ggccgaaggt gcgcagcagg tcgtggaagc ggtaccggcc gggcgtcggg
    18841 gactccagca tcgccacgtc caccagggat tccagtacct cctccacgtg gaactcatcg
    18901 gcccccaggg ccgccgcggc ggaggtcagg ccgatgccgg ggccgtcgag gcaggccagc
    18961 acccggaagg cgcgcgcctg ttcggcggag agctggcggt agccgagctc gaagacgggg
    19021 gcgatggcca gatcgccgac gcgcagctcg ttgaggcggc ggcgctcgtc ggccaggcgg
    19081 gcggtgagca gggcgaccgt ccagctgggg cgggcggcga gccgggcggc cacgatccgg
    19141 acggccaggg gcaggaaccc gcaggtggcg acgagctcgc gggcggtttc gggttcggcg
    19201 tccagccggt cgcggccgat cacccggccg aacagctcca gcgcctcggg gagctcgaag
    19261 acgtccaggt cggcctggtg ccgggcgggc agccccgcca gccggggtct gctggtgacg
    19321 aggacggcgc accggccggg gccgggcagc agcgggcgca cctgggcggc gtcgcgcgcg
    19381 ttgtcgagca cgacgagcat ccggcggccg gcggtcatcg accggaacag cgccgcccgc
    19441 ccctcgacgt cggcgggcag ggcatccgcg gtgaccccga gcgcggcgag gaagccgacc
    19501 aggacgtggc cggggtcgca ggggtcgtgg gcgtcggtgc cgcgcaggtc ggcgtacagc
    19561 tggccgtcgg ggaagcggtc ccgtacccgg tcggcggtgt ggagggcgag ggcggtcttg
    19621 ccgacgccgc ccatgccgga gatcagcgcg agggccggcc cgctgtcgcc ggccggggtc
    19681 agggcctcgg cgaggcgtcg tacgagggcg gcccggccgg tgaagtcacc gggcgcgctg
    19741 ggcgtctgtg cgggcacggg cggcgcctcc ggctcgggct ccggcccgcc ccctcccccg
    19801 ccctccgtca cggcggcggc agtgtccggc gcgggcccgc cggacagggc gacggcgccg
    19861 ccccggcgcc cgccgtcctc cgccccggcg agttcctgat cgccgctcag gatgcgctgg
    19921 tgcagcgaca gcagctccgg tccgggctcc aggccgatct cgctgatcag cccctggcgg
    19981 gcggtacgga acaggttcag ggcgtcggcc tgacggcccg tccggcacag ggcccgcatc
    20041 aggagcgcca cgggccgctc ccgcagcggg tgttcggagg tcagcagccg caggtcgggc
    20101 acggccgcgg cctcgccgcc cgcctcgatg tccagctcca ggcggtcctc cagcaggcgc
    20161 agccgcagct cctccagacg ggaccgctgg cgctccgcgt acggccccgg cagcgcggcc
    20221 agcggctccc cctgccacag cccgagcgcc tcccgcagca gcttcgcggc cgcctcgcgc
    20281 cgccccgcgc cccgctcgac ggcggcccgg gcggccagct cctcggcctc ctgcacgtcg
    20341 aggcacggct tctccagcac gagccggtac ccgtccccga cggagacgag cacaccgggc
    20401 tccgccagca ccttccgcca ccgccaggcg tacgtccgca gggtggtcac ggccgcgtgc
    20461 ggcggctcct caccccacag cgcgtcgatg agctccccga gcccggcccc gtgcccggac
    20521 cgcagcaaca gcaccgccag catggcctgc tgctgcggcg tccccgtccc gagccgctcg
    20581 tccccccgat aggcccgcat cggccccagc agctcgaacc gcacccctgc cgtcattccg
    20641 ccccctgtag tcgcctcccc cccgcctcca tcaggagggc ccaaaccccc ctcgggttgc
    20701 ctgcaccccc caaccactcc cgccccgagg cgcggttccc tggagcgcga tcccccgcac
    20761 gtccgtcagc cactgacgca ggcgcacgcc tcgtggcgga agaatggcaa gccccagcgt
    20821 caccgccgac ttcttgagga gttgatccga ttcgttgagg atcaggaatt cgcgaatctc
    20881 atccgccaac tgccgaaggt cactttccga ggcacctgaa acgtagtcgt cgagagcctc
    20941 cccataagag gagtactcca gcgaggagtc ctgatggaaa tacgccgcca gcaggtgctg
    21001 gagtccggga aagcgttccc tccattccca tgcggtgcga ggaggcgact gggagggatt
    21061 cgccggctct gcgaggaact gacgcaggtg cctgccgatg acggcgagac agctctccac
    21121 cgtctccccg cggggcgggt tgacgtgggg caagaggtcg acgtcatccg cgatctcatc
    21181 gctgaacagg cctgtctcga tgaggtcgtc gatttcggcc gctgcctcgg cggcgcgtgc
    21241 gggatcgcgt gcggcttgcc tgaggtaggc gctgagcgca actccgcgac ggtcctccgt
    21301 gtcatcgaag gcgtagccgg tcaccgtata agagtccagg agctcgcgca gctcacggaa
    21361 acggtcgttc gacggtgtca cctgttgatt tccttactct tcactacgta ccccgggagc
    21421 gggcaggcct gtggtgtcgt catcgagatg cagtcaggcc tgttcccacg gtgcgggatt
    21481 cgggcggcgg tgccaccacc aaccgtgcgg cgcctgctct acggagccgc cggtcagctc
    21541 tctgcggaga ctccctgccg ggtcatcctc cgtcgcagcg gcaaaccgcc cgtccagctg
    21601 ctccacggcc ccgtcgagca gctcagtgac atcacgcggc aggtgagcac cgattccggc
    21661 cagctcgtca cgcgattcca gccgctcccg gtaaaggccg gccggatacc agcccgacgg
    21721 cgcccacccg gattccattt gcgcgatgac cctctcccac gccatcaggt tgcccttcgc
    21781 ggtccagacg gggctgccgg tgccgtcgtc gagggaaagc ctcgcgaggc ccgaggcggc
    21841 ctgccgcacc ttctccaccg atgccgcgaa ggcccaggcg accggcgtgt ccggccgctg
    21901 ttcccgtacg atctcggcga atctcgtcac ggtcgccccg ggcagctgcg gcaccggcgc
    21961 ctcgacggcg gtgatcgcgt aaaggggagg ctcgtcgtcg gagagttcga gccgggcccg
    22021 ggtgagaacg ccttccggcg tcaccgccca gtaggcactg ggcggtgctt cctcagcggg
    22081 aaacaggacg gtcgtcatgg cggccttcgc gaaccctgcg gcgaggtcgg actcgggcgg
    22141 ctgatcagcg acgcgttcct gggcgtagac gtccagcgac caggccacat caccttgaac
    22201 ggcccggtat tcgcacgaga cgggcgcatc ccagttccgg aggtcggggt cgccgtcaga
    22261 atccgccacg tccacgtcac ccaccgcgaa accgaggcat cccgcaagtg cgagggccac
    22321 ggtctcgggg ccgacggggt cgacggtaag gaggttgtac gtcacggata cgtcccgttg
    22381 tagatggcca gcgctttctc gacgatgcgt ccgaaaggtt catcaggcca gcccgtggac
    22441 gaccccgctg atcgacctgc gcgatcagga tgtcgcggct gtcgatcacc tctcccctac
    22501 ggatcatgca ccacccgcta cactgaccgc ggtggcccgg cctcacagcc aggcctccat
    22561 gcctcgcctt cgtggggctt gacggaaacc ctagaagccc aggtcagagg cttaccgcgg
    22621 aagccgccga aaacgctccg ctccccttct cggaacgcac agctcatcgc tgcagctcag
    22681 agccctatcg ccgacacggt cgacacccag ctcaccgaat ggccgagacg gccctgccag
    22741 cccgtctcgg tcatccgcca ttcagggcac cagggacagg gcgcgtcgag gttccgatgc
    22801 gggcctctgg ccgccgccgt cgaccatcgc catggtcagg ctgaagagca tcttgttcat
    22861 gtgtgaaagc tggctcgcat tgctcctacc tcgcctgtcc aaacatgatc aaatggcgcc
    22921 atggtgtggg acgaatggga aaaggcaaag gtggatgtgg ctggcgcgcg ccaggtgtcg
    22981 atgcgcctca accaggtgac cagcggacct ggtggcggtc aggccgacct ggtcgtacac
    23041 caggatgacc tgggcgaagt gggtcatgag gctttcctgc tgcatggcca actgcagaag
    23101 caggccgaca tcgccggcgc cggtgccgat ggctcaggaa gcggctccac gatgcaggcc
    23161 gcagcatcct tgaagacggc cagcttctca ctcggcggcg agctggagac caccgtgtcc
    23221 gtgtggacct ctcaggtgaa gacggtcctg caggcatgcg cccacatctc gaaccacctg
    23281 gactactcca agaaggcgca cgccgcggac gacgaggcca tcgcggcctc gctccgcaac
    23341 cgcgacggct cggccgtgtc cgtctcccgt atcgacgagt acctcaagta gggagcacgg
    23401 catggactac tcggacctca tggaactgaa cctcacgaag ctgggatccg ccgttcagga
    23461 ctggaagcgc acggccgacg ctctgcagag cctgggggta caggcgcgcg acggggcaag
    23521 ggccaaggcc gagaaggccc gctgggaagg cgtgaacgcc ggtgtgaccc gcgccttcgt
    23581 cggcaagacg gtcaaggaga tagaggacct ccacacggag gcccagagca tcttcagcat
    23641 tctccaggac gcccactccg aactggtggc catccagaag caggcgaaga acttgactgc
    23701 cgacgccaag gaggagggct tcaacgtccg tgtggggcaa ggcggagcgg tgacgatcga
    23761 ggatgtcctg gtctgcgagg tggacggtcc cggccagcgc aagcaggacc tcatgcgctg
    23821 gtacgccgac accctgagcg gagtggtgag ccatgcggcc gaggtcgatg ccgctgccgt
    23881 acgcgctttg cgctccagtc acggtgcaga tccgcacaac gccggccacg cgacatacac
    23941 ctccctcgac gaggacatgc ttccccgggc cgtgaagctt gcaggactgg acggggaggc
    24001 caacgacaag cagcggaagg agctgcagcg gctctggcag tccctcagcc ccgaggcccg
    24061 ggcccagctg tggacccagc accgggacga cctccttgcc gccggcctgc tccggcctca
    24121 ggtcaagcag gtcgccgcgg atgacggagc tggaccgtac gacgtcgaat cgccaggcct
    24181 gtcggactac tggaagcaga tccaggccaa cgggatctcg aactccggtg acttcatcgg
    24241 caagaccgac gcggccaggc acatggatca ttacctccaa ggcagcggca agacgctcga
    24301 cctagacgtc gaccgcatgc tggccgacga cccggccctg cgggacgagg cggcgcggat
    24361 ccgcgccgcg gagcaggacg agtggcggcg ccaggcactg gaggccttcg agaggtccgg
    24421 tggcaagccc gttgccatcc ccgtcgaatc cggcagcgtc ggatacgaac acgaaatggg
    24481 gccggacggt acgaacaact ggtacctggc cgtgggccgg ggcatgacca acacgacagg
    24541 cgtggtcacc gcagtccccg gacccgacgg gaaaccgcag gtcagcatcg actatcaggt
    24601 caacgtgtgg gaccgctaca actgggacca agacaaggcc accccgatcg gaccgaccac
    24661 cgtcaccgac
//
