LOCUS       NC_021252              20687 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8278022
            Orig. end                         :: 8298709
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20687
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="31"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20687
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20687
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10687](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10687)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     misc_feature    867..881
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.96"
                     /tool="antismash"
     misc_feature    925..940
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    927..941
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(929..940)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     gene            1077..2177
                     /locus_tag="AORI_RS78375"
                     /old_locus_tag="AORI_7470"
     CDS             1077..2177
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441636.1"
                     /locus_tag="AORI_RS78375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7470"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_005165317.1"
                     /transl_table=11
                     /translation="MGRPIRTRRQATLASLAAELGVSRTTVSNAYNRPDQLSPELRRRV
                     LETARRLGYPGPDPVARSLRTRKAGAVGLLLTENLSYAFRDPAAVGVLEGLALACEDAG
                     VGLHLVPASPGREDVAAVHRAGVDGFVVYSVPDDDPHLGAVLERPVPTVIVDQPRVDGV
                     DRVGPDDAAAVTAMAEHLISLGHRQIGVLCMRLARERNDDFVSIQRQSAAHFHVQRIRL
                     EALAAAFSAAGVDWATVPVVERFDHTVDDGASAARQLLDAYPQVTAVICTSDILALGAL
                     AEAERRGLRVPQDLTVTGFDGITEAERSGLTTVHQPVLEKGKAAGKLLLSSADRVGPKV
                     ITLQTELRVGRTSAPPRTAEERWFGP"
     misc_feature    complement(1088..1105)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            2229..2720
                     /locus_tag="AORI_RS78380"
                     /old_locus_tag="AORI_7471"
     CDS             2229..2720
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641910.1"
                     /locus_tag="AORI_RS78380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7471"
                     /product="carbonic anhydrase"
                     /protein_id="WP_016337733.1"
                     /transl_table=11
                     /translation="MTSIDVLLKRNQELGDVTPGDRSSPRPSLHVTILTCMDARIRVFE
                     IFGLIQGEAHILRNAGGVVTDDMIRSLALSQRKLGTREVLIVQHTDCGLSMVTEDDFKD
                     ELEAASGLRPTWSVEAFRVVEDSVRRSVQRVRRSDFLAHTDNVRGFVYDVKTGRLSEVE
                     "
     gene            2852..3727
                     /locus_tag="AORI_RS78385"
                     /old_locus_tag="AORI_7472"
     CDS             2852..3727
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165321.1"
                     /locus_tag="AORI_RS78385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7472"
                     /product="A/G-specific adenine glycosylase"
                     /protein_id="WP_016337734.1"
                     /transl_table=11
                     /translation="MGVDADVLTGWFDEVGRDLPWREPECSAWGVLVSEIMLQQTPVAR
                     VQPIWLEWMARWPVPSALAASSQGEVVRAWGKLGYPRRALRLHAAAAVIAAEHGDVVPS
                     DVDTLLALPGIGAYTARAVAAFAYGKRAPVVDTNVRRVVARAVHGAGDAGPPSNTRDMA
                     DVEALLPPEDAPAAKLSAALMELGALVCTARSPRCADCPIFEDCAWQHAGRPAYAGPAK
                     QVQKFAGTDRQVRGLLLDVLRGSEGPVEKARLDLVWHESGQRDRCLDSLLVDGLLEQTR
                     DGLFALPGEH"
     misc_feature    2873..2888
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.1"
                     /tool="antismash"
     gene            3816..4778
                     /locus_tag="AORI_RS78390"
     CDS             3816..4778
                     /EC_number="3.5.1.28"
                     /GO_function="GO:0008745 - N-acetylmuramoyl-L-alanine
                     amidase activity [Evidence IEA]"
                     /GO_process="GO:0009253 - peptidoglycan catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028566.1"
                     /locus_tag="AORI_RS78390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="N-acetylmuramoyl-L-alanine amidase"
                     /protein_id="WP_123798681.1"
                     /transl_table=11
                     /translation="MADFDRRTALKGGLTVSAVGLLGTATISAADAASGVAEPKIYGTA
                     AWNARPPSGAIEVQNHKPTYIVVHHTVEPGNVTDYTLEHAFWASRSIQNFHMDTRGWID
                     TGQQFTNSRGGHITEGRHRSLEILRGGTQHVLGANVGNNNSTCIGIENEGLYSKEDVTP
                     ALWDSLVKLVAYIASQYDISPEFIKGHRDFNSTECPGTVLYNRLPELRTEVGKLLGTAS
                     PKVDLPEWPLLKPGDSGPRVRTAQELLRARGFAVPVDGLFGQSTKDAVAAVAARNGLER
                     DACGATAATDETGFLGSDVWPLIVGSGTDPRALKARLAG"
     misc_feature    complement(3817..3831)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(4723..5877)
                     /locus_tag="AORI_RS78395"
                     /old_locus_tag="AORI_7475"
     CDS             complement(4723..5877)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337737.1"
                     /locus_tag="AORI_RS78395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7475"
                     /product="MFS transporter"
                     /protein_id="WP_016337737.1"
                     /transl_table=11
                     /translation="MLPLPALLALTTTVFLGCLTEVLPAGLLLGMSEELGVSPSATGQL
                     VTVYAITTALTAVPLTGATLRVPRKRLLLVLIFGFLATNLVIAVSSSYPLILATRVVSG
                     ALTGVMWSLVAGYAMRLAPAGLTGRALAVAMSGTPIGFALGVPAGTALGEFADWRWAFA
                     AMALISVPLLAWVSVVVPAVPAERTEVTRPLAASRLPGMRPVLATVALFSLGHNVAYTY
                     IGPVLAGLGVEQMLGAALLVFGCATVGGLIAVGSALDSRPRAVLLSCSVATAAAIVLMG
                     ISDGVHGLVLAAAGLWGLGFGGAPTAFQAVTAVLAGPTADAAQSLTIAAWNGAVAGGAL
                     VGGLLLPLGTSSLPWCAALLILVPLLFSRRVVLSVPADRCRSRR"
     gene            6044..7483
                     /locus_tag="AORI_RS78400"
                     /old_locus_tag="AORI_7476"
     CDS             6044..7483
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632027.1"
                     /locus_tag="AORI_RS78400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7476"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_016337738.1"
                     /transl_table=11
                     /translation="MTVRIRWQEPLCTALLATTMLGACPASAVAKPAPGSDGYVHVSPD
                     GTVLGPDPYYPKDGNGGYDVDRYSLALDYAPYSMFLSGKATITATATQDLDRFDLDLRG
                     LTVRSVTVDGVAAAFRREGEHELVITPRTPLANGARFTVVVGYDGRPEPIPTARGRVGW
                     LAAYGDSAVATGQPRSAMTWFPVNGTEVDKATLRVSVTVLDEFSVLGNGFQVSDVPAGV
                     GRHTVTWSEETALAPSTAMLGIGRWEVERITLPGGRTAINAYHPCAVDKRKIGGRLPEV
                     LEFLTGKFGDYPQSAAGGLFLDRSLGYTHGAQTRPVYGRAATIADLVYASAYQWWGAGV
                     SGKMWRDALMPESIARYAVWLWDEKNGVDLDRRYREMVAKVRDDAAFWAPKLTDPGKGM
                     EFAPTAKAVLMVHALRRLVGDDAFFHILAGFPVINPQGNQNWHDFELYVSAMTQRDLGE
                     FTHAWLDGTVRPPDSLLFPGS"
     gene            complement(7708..8688)
                     /locus_tag="AORI_RS78405"
                     /old_locus_tag="AORI_7477"
     CDS             complement(7708..8688)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028563.1"
                     /locus_tag="AORI_RS78405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7477"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_016337739.1"
                     /transl_table=11
                     /translation="MTKEFDVVQLDVHHLRVIRAIADTGSLSRAAIALGVTQPAVSAQL
                     KRLENMLGYQLFDRCEGGVTPTPMGELLLRRTAALLPQLDKLLEDIEQRVCPSGPPAVV
                     RVAAVASALVACLPSLVTRLWPEVTEVQVVHDDHPERLLPLLAQRRAELALVKDYPGYE
                     LEIPANVDTAVVVTEPTFVLLPACHPLAREKVVDLRDLRDESWVMVSDSSAATFTKYFA
                     DTCARHGFTPKFTHQVTSQQVALLVVKAGAIGLSQPICDPGDHGIVTRPLRGDVLPRRH
                     VLAWNKETFVAGRREELLSAVVDAYWAEARTAPVYAEYLDRPREW"
     gene            complement(8685..9998)
                     /locus_tag="AORI_RS78410"
                     /old_locus_tag="AORI_7478"
     CDS             complement(8685..9998)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005165331.1"
                     /locus_tag="AORI_RS78410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7478"
                     /product="cytosine permease"
                     /protein_id="WP_043848430.1"
                     /transl_table=11
                     /translation="MEHDDFSLRRVPADRRYSWVSVALQRFGQVSSFHQFLLGAVLGFG
                     MTFWEAVLAITIGSVLLEIITILMGVAGTREGLSTSVLARWAGFGTGGSSLVGLLMTVS
                     LAGWFGVQNDVFAHGLHALMGGPPVWVWALAGGALVTAIVVFGFHAMAWTAYLTVPAFL
                     ALAGFSIISALGDHSLPTLMSEPPPGPAMSLAQGTTLVAGAFIMGAIMTPDMTRFNRTA
                     SDVVKQTLVSVTLGQYLIGLIGVLLAHAAKSADVVGIITSSSGVLGTLILVTAILKIND
                     WNLYSSSLGLVNAVQVLLSRRLDRTTATLLLGGLGTVLSAIGILDHFTTFLTWVGVLTP
                     PVAGVVIAEYYVVRRWKPDLEAGRASGELPSTCPSWVPAALICWAAGAAVGIWLPWGIP
                     TVNSVFGAFLLYVLLGRRTTAAAVPAATTSSGGSKTRS"
     gene            complement(10001..10687)
                     /locus_tag="AORI_RS78415"
                     /old_locus_tag="AORI_7479"
     CDS             complement(10001..10687)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028561.1"
                     /locus_tag="AORI_RS78415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7479"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_016337741.1"
                     /sec_met_domain="CDPS (E-value: 1.2e-77, bitscore: 259.4,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRPLPLTEHCADPLARAEHVCLGVSPFNSHFTVERIADLARWAM
                     SAFRGFHFFVPDGPSAFTLEALGYDPVRAAQKAQRQGNYTRNKIVRALQQVCPSDPHTL
                     ILDASVLEADSAYLGLLSEAHHRFATDPEFAEQCLGATGWVLDRRLPEGEHPTRDQLRS
                     AVRYFLAELPMFVGTVAVAGVESSVFAYHQRVGFLERLYRGELSWRPLPGQGFVVLEQA
                     VPEPVE"
     gene            10847..11800
                     /locus_tag="AORI_RS78420"
                     /old_locus_tag="AORI_7480"
     CDS             10847..11800
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028560.1"
                     /locus_tag="AORI_RS78420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7480"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_016337742.1"
                     /transl_table=11
                     /translation="MEIQVRHLRVICEIAAAGSLNRAAAGLGLGQPALSHQLRRIERMV
                     GGPLFHRDQQGVRPTELGALILRRARAIVLTFDELEHDFHRQEPETGESIRIGWNDSAI
                     TGSLLGGLRDLRPGEPFRTRADTSRTRLLAQVANRGIDLALIMICGRRGLPVPPEVRTL
                     TLVEEPSFVAIPAEHPLAGEEEIELAELAGEDWIVSSGGDGCRVVFREMCLAHGFDPRI
                     SHDVDIDTVREDLVSGGYGVGLVQPTRPPADGLAIRPLAGAPMCVRHVLAWREDGPCAR
                     GVPELATEARAGYWRLAERTASYRSWLHRHGRVAAG"
     gene            11894..12244
                     /locus_tag="AORI_RS78425"
                     /old_locus_tag="AORI_7481"
     CDS             11894..12244
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028559.1"
                     /locus_tag="AORI_RS78425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7481"
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_016337743.1"
                     /transl_table=11
                     /translation="MLPLITRTELLSRMESGSVVVVDTMPVAYFEKEHLPEARNIPGFP
                     YEQAAEFTDRLAPTVLPDKGAAIVVYCANTPCRNSEFVGRRLLELGYTNVRKYREGIED
                     WVANDLPTWSSS"
     gene            12257..12691
                     /locus_tag="AORI_RS78430"
                     /old_locus_tag="AORI_7482"
     CDS             12257..12691
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632034.1"
                     /locus_tag="AORI_RS78430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7482"
                     /product="thioredoxin family protein"
                     /protein_id="WP_016337744.1"
                     /transl_table=11
                     /translation="MSKVKRFVCVLAGALALVTGFGGGVASAAPKAENVKTVTSANYAE
                     VMNISKQKLVIMDFGATWCPPCRQMKPVIERLAGEYGGRFLLGEVDVDQSRDLSTRYNI
                     RYLPTLVGVRNAAELPSSRNIGYPGEARLRAWIDAQLAKG"
     gene            complement(12673..13470)
                     /locus_tag="AORI_RS78435"
                     /old_locus_tag="AORI_7483"
     CDS             complement(12673..13470)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-117). E-value:
                     4.8e-23. Score: 74.0. Matches aSDomain:
                     nrpspksdomains_AORI_RS78435_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632035.1"
                     /locus_tag="AORI_RS78435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7483"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_200870944.1"
                     /sec_met_domain="PF00561 (E-value: 4.7e-18, bitscore: 64.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.4e-18, bitscore:
                     65.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGSLVVIQRDGLVTFGGDGPPIVLLHGLMGRATTWWRVARRLEP
                     YGRVHGLDARGHGRGPRGGPWRTERFADDVAEVLRTLDEPAVLIGHSMGGLHAWVTAAT
                     HPELVRAVVCEDFAPDQRGRTVDTWRGYFESWPVPFRSLAHVREFFGDTGDYFIECVEE
                     REDGYHLIASLTDLYEIAAEWGRRDFWEFVERVKCPLLAIEGERTAMPHGQQAELAARV
                     PGGLGRHIVVQGAGHVVHDEAPETYLGAVEAFLSDVIGQPFAS"
     aSDomain        complement(13120..13410)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS78435_Abhydrolase_1.1"
                     /evalue="4.80E-23"
                     /label="AORI_RS78435_Abhydrolase_1.1"
                     /locus_tag="AORI_RS78435"
                     /protein_end="117"
                     /protein_start="20"
                     /score="74.0"
                     /tool="antismash"
                     /translation="PPIVLLHGLMGRATTWWRVARRLEPYGRVHGLDARGHGRGPRGGP
                     WRTERFADDVAEVLRTLDEPAVLIGHSMGGLHAWVTAATHPELVRAVVCEDF"
     CDS_motif       complement(13162..13218)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS78435_0001"
                     /evalue="1.30E-04"
                     /label="NRPS-te1"
                     /locus_tag="AORI_RS78435"
                     /protein_end="103"
                     /protein_start="84"
                     /score="14.5"
                     /tool="antismash"
                     /translation="PAVLIGHSMGGLHAWVTAA"
     misc_feature    complement(13456..13458)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13469..14911
                     /locus_tag="AORI_RS78440"
                     /old_locus_tag="AORI_7484"
     CDS             13469..14911
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028556.1"
                     /locus_tag="AORI_RS78440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7484"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_043848431.1"
                     /transl_table=11
                     /translation="MRSRVPAAGLVLGVVCALIIGCSADPPPATPPPPPPMNPAPGAPG
                     AGDPYYPMDGNGGYDATEYQVGITYDPAKGRLDGDTTVIAKATQDLNRYNLDLRGLTVQ
                     SVEVDGKPAKFAREGEFELVVTPAEPIRNGTSFRTKVLYGGDPSATPKAGGSENGWQKS
                     KDGGAFIVGEPHSASFWYPVNETPRDKAMFTLTARVPDGWTVISNGREIQKAAANGWTT
                     TSWQERTPVAAYLTTVAIDKFTVDRMALPDGTPVVNAYAPGAEDRRDTGRRLPEIIGFL
                     SSKFGPYPVDAAGGIYLDEDIHFSLETQTRPTYAKWADLITVVHETAHQWFGDSVTLNS
                     WSDICLNECLASYAQWLWQESRDNEDLDVRYRAALEIMRGSADFWKPKLVGMGAGQEFR
                     GVYDKGILAVHALRRKIGEGAFARLLKEWPAAYRNANATWADFEAFTIKLSEQDLRPFF
                     DAWFHGTTIPPDAELLPGTLRG"
     misc_feature    13760..13762
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14934..16124)
                     /locus_tag="AORI_RS78445"
                     /old_locus_tag="AORI_7485"
     CDS             complement(14934..16124)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632037.1"
                     /locus_tag="AORI_RS78445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7485"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_043849223.1"
                     /transl_table=11
                     /translation="MADTKILISGASVAGPALAFWLTRYGFQVTVVERAPSLRPGGQAV
                     DLRGTAKEVARRMGLDERIRAACTDTKGETLVDRKNRTKATIRADDFDGDGVVAEIEIL
                     RGDLTEVLYEATKERTEYVFGDRITALDERDDGVGVTFASGSRATFDLVIGADGLHSGV
                     RALAFGEESRFVRHLGSYLAFFTVPNRLGLRNWAVGYDDVGRSAGIRAVRDGDEAMAYF
                     GFASPKIDYDYRDVEAQKALVRRFAAGMEWEAPWLLDRMDEAPDFYFDSCAQVIMDSWS
                     RGRVGLLGDAAFCPSPLSGQGTSLAFVGAYVLAGELAAGLDTGLKRYEAVMREFVEKTQ
                     ELGRENAESIFAKSRTGLRMRYLAMRVMRLKPFAALASRKMRDVVNGIDLPDYPRI"
     gene            16186..16494
                     /locus_tag="AORI_RS78450"
                     /old_locus_tag="AORI_7486"
     CDS             16186..16494
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084240.1"
                     /locus_tag="AORI_RS78450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7486"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_016337748.1"
                     /transl_table=11
                     /translation="MAVVKINAIEVPEGAGPELEKRFAARLHAVDNQPGFLGFELLRPV
                     SGESRYFVYTKWESEEAYQAWASGPAREAHAGERAKPVSTGANLLEFEVVQASKPGE"
     gene            16487..17299
                     /locus_tag="AORI_RS78455"
                     /old_locus_tag="AORI_7487"
     CDS             16487..17299
                     /EC_number="2.3.1.286"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337749.1"
                     /locus_tag="AORI_RS78455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7487"
                     /product="Sir2 family NAD-dependent protein deacetylase"
                     /protein_id="WP_016337749.1"
                     /transl_table=11
                     /translation="MSELERAAELIDGAGALLVCAGAGMGVDSGLPDFRGDEGFWKAYP
                     PYERLGISFVELADPRHFAEDPELAWGFYGHRLALYRATVPHDGFRLLLSWGARKPGGT
                     RAFTSNVDGQFQKAGYPHVAEAHGSIHHLQCLDRCTKEIWPADDVEVPIGEDTMRAQAP
                     LPSCPRCGGLARPNILMFGDYDWLGQRSQAQLDELNAWRRAHRDLVVVELGAGQAVPTV
                     RRYSELASAATGALVRINPREPGIRHGRGVSLATNGLETLEALDALLS"
     gene            complement(17577..18605)
                     /locus_tag="AORI_RS78460"
                     /old_locus_tag="AORI_7488"
     CDS             complement(17577..18605)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337750.1"
                     /locus_tag="AORI_RS78460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7488"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_016337750.1"
                     /transl_table=11
                     /translation="METAAPARVIGILDGMVIEERPVRPAARPGTGRKLAGGILIAAVV
                     PFAVLTALRLVGYDGNTYTIAALALTPYAGIATLVLGLLALGLRRWWTAVVALALTCTI
                     ASMVLPRAFANEQKALDGKHVRVLASNMLGGGADPDRIVGYVKEHQVDVLSLTELTPEA
                     ITALDRAGLFQVLPYRVLHPAEWASGSGLVSKYPLTPLKLSGDSDHKQPSASVDLGDGV
                     RVEVVAVHPSAPMWDRYEWVAEAKDLPYADAEHDIRILAGDFNASLDHALFRELLTRGY
                     VDAADELGKALQGTWTNGIAPPVAIDHVLADKRTAIADFKVLETPGSDHDAVYAEIVLP
                     GK"
     gene            18743..19720
                     /locus_tag="AORI_RS78465"
                     /old_locus_tag="AORI_7489"
     CDS             18743..19720
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028550.1"
                     /locus_tag="AORI_RS78465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7489"
                     /product="daunorubicin resistance protein DrrA family ABC
                     transporter ATP-binding protein"
                     /protein_id="WP_016337751.1"
                     /transl_table=11
                     /translation="MTHAIRAEGLVKHYGETKALDGVDLEVPAGKVVGVLGPNGAGKTT
                     AVRILATLIRPDRGHASVFGYDVVKNPMAVRSMIGLTGQYASVDEDLSGTENLVLIGRL
                     LEFSRADAKQRAAELLERFELTDAAGRAIKTYSGGMRRRLDLAASLVGRPKVLYLDEPT
                     TGLDPHARNEVWAVVRTLVADGTTVLLTTQYLEEADQLADTITVFDHGHVVANGRADEL
                     KRRTGGQTLQVRPSALADLDAVERILAGLTGVRPNRDDDTGLLTAPVADPVLLSTLVRK
                     LDEAGITADELALRLPSLDEVFLALTGKKTDESTKDTTPEGSLV"
     gene            19717..20514
                     /locus_tag="AORI_RS78470"
                     /old_locus_tag="AORI_7490"
     CDS             19717..20514
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020632041.1"
                     /locus_tag="AORI_RS78470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_7490"
                     /product="ABC transporter permease"
                     /protein_id="WP_016337752.1"
                     /transl_table=11
                     /translation="MTTIAAPAPRRVSLSSSTRHGLSLAWRGVLKIRKNPEQLADVTLA
                     PIIFLVMFVYLFGGAIMGSTESYLQMIVPGIMVFNILQASMTVGVQLNTDVTKGVFDRF
                     RAMPIARSAPLIGAVLADIVRYLVCLVVLMVVATIMGYRIQTGPAEFALAILLVIAFAL
                     SFCWASVFVGMLVKSPGAVQGLMFVVLMPLTFGSNVFVGTSTMPGWLKAWADISPVTQM
                     SDVLRGLMNGGPIAGPLTGALIWMAAALAVFFPLATWAYRKRV"
ORIGIN
        1 ggtcacaccc tgcgggagcg tttcggtgac gtcgacgacc gcgataccgg cggtcttggc
       61 gtcgccgacg acctgctggg tgaccggggt ggtggtctgc gcgttgttga tcagggcctt
      121 gacctgcttg ccggagatca gctgcttgac ctcgttcagc gcggcggcgg gcacgtcctg
      181 ctccgcttcc acggcctcgg cgaaggcggg cggcgtcgcg tcggtgacct tcgcgctgtc
      241 gagcaggtag tgcgcgaccg gctcggtggc gacgaccttg gcgttcgagg cgcccaggcc
      301 cgaaaccttc ttcagcagct cctgggtctt gcccttgaac gccgtcgcgt tggcagtgaa
      361 ggcgtccttc gaggcgggct ggatctcgcc gagcttcgcg gcgacctggt cggcgatctt
      421 ctcgacaccg gggaggctgt accagacgtg ctcgttctcg ttgccggtcg cggcgatgtc
      481 gacggcgacc agcttctgcg cgccggtggc ttggtcggcg agcttcgaga agaagtcgtc
      541 gtagccgccg ccgttggaca gcgtcagctt cgcgttcttc gcggcgatgg cgtcgctcgc
      601 ggtggtctcg taggagtgcg gatcggccga ggggtcgtgg atgatcgagg tgacctcgac
      661 cttgtcgccg ccgacggcgg tcacgacgct gccccagacg tcggtcgagg cgacgacctt
      721 gatcttctcg ccaccacccg ggttcgcggc ggacgcgttc ggcgaaccgg agcccgtcga
      781 cgccttgtcg ctcgacgcgc aagccgtcgc gccgagcgcg aggacggcca gggccgacac
      841 ggccgcgaaa acactcttag tacggcggga attcatttac tgcactcctg cggatgccca
      901 ggccaggtgt ccccaatgcc gggtaatgga aaccgttgtc agattcaact gtaccccatc
      961 cggattaccg cgttccccgt ccaggcgcga gctgtaccca gggtcactct gaatcgagac
     1021 ctgccacacg tcgggtgatg cttctgcaaa acgttctgaa ccgttacggt ttgcggatgg
     1081 gccgtcctat ccgcaccagg aggcaggcga cactggcgtc gttggccgca gagctcggtg
     1141 tgtcgaggac caccgtctcc aacgcctaca accgacccga ccagctgtcc cctgagctgc
     1201 gccgccgcgt cctcgagacc gcgcgccgcc tcggctaccc gggcccggac ccggtggccc
     1261 gttcactgcg gacgcgcaag gccggcgctg tcggtctttt gctcaccgag aacctctcct
     1321 atgccttccg cgacccagcc gccgtcggcg tgctcgaagg gctcgcgctg gcctgcgagg
     1381 acgcgggcgt cggcctgcac ctggtcccgg ccagcccggg ccgtgaggac gtcgcggccg
     1441 tgcaccgtgc cggtgtcgac ggcttcgtcg tctactcggt gcccgacgac gacccgcatc
     1501 tgggcgccgt gctggagcgc ccggtgccga cggtgatcgt cgaccagccg cgggtggacg
     1561 gcgtcgaccg ggtcggcccg gacgacgcgg ccgcggtcac cgccatggcc gagcacctca
     1621 tctcgctggg ccaccggcag atcggcgtgc tgtgcatgcg gctggcccgc gagcgcaacg
     1681 acgacttcgt ctccatccag cggcagagcg ccgcccactt ccacgtccag cggatccggc
     1741 tggaggcgct ggccgccgcg ttctcggcgg ccggggtcga ctgggcgacc gtgccggtgg
     1801 tcgagcgctt cgaccacacc gtggacgacg gcgcgtcggc cgcgcgccag ctgctggacg
     1861 cgtatccgca ggtcacggcc gtgatctgca cgtcggacat cctcgccctc ggcgcactgg
     1921 ccgaggcgga gcgccgcggg ctgcgggtgc cgcaggatct gacggtcacc gggttcgacg
     1981 gcatcaccga ggccgagcgt tccgggctca ccacggtcca ccagccggtg ctcgaaaagg
     2041 gcaaggcggc gggcaagctg ctgctcagct ccgccgaccg ggtcgggccg aaggtgatca
     2101 ccctgcagac ggaactccgc gtcgggcgca cgtccgcgcc gccgcggacg gccgaggaac
     2161 gctggttcgg gccgtgatcc gcgtccgccc gcgttgccgt cgcccggcgc gtcggttcca
     2221 atgaacacgt gacctcaatc gacgtactgc tcaagcggaa ccaggagctg ggtgatgtca
     2281 ctcccggtga ccgctcgtct ccgaggccat cgctccacgt gacgatcctg acctgcatgg
     2341 acgcccggat ccgggtgttc gagatcttcg gcctgatcca gggtgaagcg catatcctgc
     2401 gcaacgcggg cggcgtcgtc accgacgaca tgatccgctc gctcgcgctc agccagcgga
     2461 agctcggcac gcgtgaggtg ctgatcgtgc agcacaccga ctgcggcctg tccatggtca
     2521 ccgaagacga cttcaaggac gaactcgaag ccgccagcgg gctgcgcccg acgtggtcgg
     2581 tcgaggcgtt ccgggtggtg gaggacagcg tgcggcggtc ggtgcagcgc gtgcggcgca
     2641 gcgacttcct ggcgcatacc gacaacgtgc gcggcttcgt ctacgacgtg aagacgggcc
     2701 gcctcagcga ggtcgagtag agctgaaggg gactttcccc gcatgcgatg tggggaaggc
     2761 gcccttcacc gcgtgagacg aggggaaagt ccccttcagc tacgccctgg gcccacgttc
     2821 gacgcgcggg cgcacctttt aagctggccc ggtgggcgtc gacgcggatg tgctgaccgg
     2881 ctggttcgac gaagtggggc gcgacctgcc ctggcgtgaa ccggaatgct ccgcctgggg
     2941 cgtgctcgtc agcgagatca tgttgcagca gaccccggtc gcgcgcgtcc agccgatctg
     3001 gctcgaatgg atggcgcgct ggccggtgcc gtcggcgctg gcggcgtcgt cgcagggcga
     3061 ggtcgtgcgc gcctggggca aactcggcta cccgcggcgc gcgctccgac tgcatgccgc
     3121 ggcggccgtc atcgccgccg aacacggcga cgtcgttccg tccgatgtgg acactctgct
     3181 cgcgttgccg ggtatcggcg cgtacaccgc ccgcgcggtc gcggccttcg cctacggcaa
     3241 gcgggcgccg gtggtggaca cgaacgtccg gcgcgtggtc gccagggcgg tacacggcgc
     3301 gggtgacgcc gggccgccgt cgaacacccg cgacatggcc gacgtcgagg cgttgctccc
     3361 gccggaggac gcgcccgcgg ccaaactctc cgcggcactg atggaactcg gcgccctcgt
     3421 ctgcaccgcg cgctcgccgc gctgcgccga ctgcccgatc ttcgaagact gcgcttggca
     3481 gcacgcgggc agacccgcct acgccgggcc cgcgaagcag gtccagaagt tcgccggcac
     3541 cgaccgccag gtgcgcggtc tgctgctcga cgtcctgcgc ggcagcgaag gcccggtcga
     3601 gaaggcgcgg ctcgatctcg tgtggcacga atccgggcag cgcgaccggt gcctcgactc
     3661 cctgctcgtc gacggcctcc tcgaacagac ccgggacggc ctgttcgccc tccccggcga
     3721 acactaacgc attacgacaa aagttggtca atggttgtca tcggcgcggt ggcgggttag
     3781 ttttccggcc aacgcgcatg atgggagtta cgcccgtggc cgacttcgac cgacgtaccg
     3841 cgctcaaggg cggcctgacg gtaagcgccg tcgggctact ggggacagcg acgatttccg
     3901 ccgccgatgc ggcgtccggg gtggcggaac cgaagatcta cggaacagcc gcgtggaacg
     3961 cgcggccgcc gagcggggcg atcgaggtac agaaccacaa accgacgtac atcgtcgtgc
     4021 accacacggt cgagcccggg aacgtcaccg actacacgct cgaacacgcc ttctgggcgt
     4081 cacgttcgat ccagaacttc cacatggaca cccgtggctg gatcgacacc ggccagcagt
     4141 tcacgaacag ccgcggcggg cacatcaccg aagggcggca ccgcagcctg gagatcctgc
     4201 gcggcgggac ccagcacgtg ctgggcgcga acgtgggcaa caacaacagc acctgcatcg
     4261 ggatcgagaa cgagggcctc tacagcaaag aggacgtcac gcccgcgctt tgggactcgc
     4321 tggtgaagct ggtcgcgtac atcgcgtcgc agtacgacat ctcgccggag ttcatcaagg
     4381 ggcaccggga cttcaactcg accgaatgcc cgggaaccgt gctgtacaac cggcttcccg
     4441 aactgcgcac ggaggtcggc aagctgctgg gcaccgcgtc gcccaaggtg gacctgccgg
     4501 agtggccgct gctcaaaccc ggcgactccg ggcctcgtgt gcggacggcg caggaactcc
     4561 tgcgggctcg cggtttcgcg gtcccggtcg acggcctgtt cggacagtcc acaaaggacg
     4621 cggtcgccgc ggtggcggcc cggaacgggt tggaacgcga tgcctgcggt gcgacggcgg
     4681 cgaccgacga gaccggcttc ctcggctccg acgtctggcc gctcatcgtc ggctccggca
     4741 ccgatccgcg ggcactgaaa gcacgactcg ccggctgaac agcagcggca cgaggatcag
     4801 caaggccgcg caccacggga gcgacgacgt tcccagcggc agcagcagcc cgccgacgag
     4861 ggctcccccg gcgacggcgc cgttccaggc cgcgatcgtg agcgactggg cggcgtcggc
     4921 cgtggggccc gcgagcaccg cggtgacggc ctggaaagcg gtcggcgcgc cgccgaatcc
     4981 caggccccac aagcccgcgg cggccagcac cagtccgtgg acgccgtcgc tgatccccat
     5041 caggacgatg gcggcggcgg tcgcgacgga gcacgacagg agcacggcgc gcggacggct
     5101 gtcgagtgcg gagccgaccg cgatcaaccc gcccaccgtg gcgcagccga acaccaggag
     5161 cgcggcgccc agcatctgct ccacgcccag cccggcgagc accgggccga tgtaggtgta
     5221 ggccacgttg tgccccaagg agaacagcgc caccgtcgcc agtacggggc gcattcccgg
     5281 cagcctcgac gcggccagcg ggcgggtgac ttccgtccgt tccgcgggta cggcgggcac
     5341 cacgacggac acccacgcca gcaacggcac ggagatcagt gccatcgcgg cgaacgccca
     5401 gcgccagtcg gcgaattcac cgagcgcggt accggcgggc acgcccagcg cgaagccgat
     5461 cggtgtgccg gacatggcca cggccagcgc gcgcccggtg agtcccgctg gagcgagccg
     5521 catcgcataa cccgcgacca gcgaccacat caccccggtc agcgcaccgg aaacgacccg
     5581 agtggccagg atcagcgggt acgacgagga cacggcgatc accagattgg tcgccaggaa
     5641 gccgaagatc agcaccagca gcaggcgttt gcgcggcacc cggagggtcg cgccggtgag
     5701 cgggacggcg gtgagcgcgg tcgtgatcgc gtagaccgtc accagctgcc cggtggccga
     5761 cggcgaaacg cccagctcct cggacatgcc cagcaacagc ccggcgggca gcacttcggt
     5821 gaggcagccg aggaacaccg tggtcgtcag cgcgagcagc gccgggaggg gcagcatgcc
     5881 ccgacgatct cttcccctgg gcgacgcggg tagtccctgg cgggtatgcc gcgcggttat
     5941 cggcctggat aacccggcgg catgacggac tgacagtgcc gcgcgccgcg cgggcgtacg
     6001 cacgatggcc gggcatcctc cccgttagag agaaggctcg ttcatgaccg tgcggattcg
     6061 gtggcaggag ccactgtgca ccgcgttgct cgccaccacg atgctcggcg cctgcccggc
     6121 ctcggcggtg gccaagccgg cccccggcag cgacgggtac gtgcacgtct cacccgacgg
     6181 caccgtcctc ggacccgatc cttactaccc gaaggacggc aacggcggct acgacgtcga
     6241 tcggtactca ctcgcgttgg actacgcgcc gtactcgatg ttcttgagcg gcaaggcgac
     6301 catcaccgcg accgcgacac aggacctgga ccggttcgac ctcgatctgc gtggtctcac
     6361 cgtccggtcg gtcaccgtcg acggcgtggc cgcggcgttc cgccgggagg gcgaacacga
     6421 gctggtgatc acgcctcgca ccccgctcgc caacggagcg cggttcaccg tggtggtcgg
     6481 ttacgacggg cgtccggaac cgatccccac cgcgcgggga cgcgtcggct ggctggccgc
     6541 gtacggcgat tccgccgtcg ccaccgggca gccgcgttcg gcgatgacct ggttccccgt
     6601 caacggtacc gaggtcgaca aagcgaccct gcgcgtctcc gtcaccgtcc tggacgaatt
     6661 ctccgtgctg ggcaacggtt tccaggtctc cgacgtaccc gcgggagtcg ggcggcacac
     6721 cgtcacctgg tcggaggaaa ccgccctcgc gccgagcacg gcgatgctcg gcatcggccg
     6781 ctgggaagtc gagaggatca cccttcccgg tgggcggacc gcgatcaacg cctaccaccc
     6841 gtgcgccgtg gacaagcgga agatcggcgg gcggctgccc gaggtgctgg aattcctcac
     6901 cgggaagttc ggcgactatc cgcagtcggc ggcgggcggg ctctttctcg accgctccct
     6961 cggctacacg cacggcgccc agaccaggcc ggtgtacggc cgcgccgcca ccatcgccga
     7021 tctcgtgtac gccagcgcgt accaatggtg gggcgccggc gtgagcggca agatgtggcg
     7081 cgacgcgctg atgcccgagt ccatcgcgcg gtacgcggtg tggctgtggg acgagaagaa
     7141 cggcgtcgat ctggatcggc gttaccgcga aatggtcgcg aaagtgcgcg acgacgcggc
     7201 tttctgggcg ccgaagctca ccgatccggg caagggcatg gaattcgcgc ccacggccaa
     7261 agcggtgctg atggtgcacg cgctgcgccg tctcgtcggc gacgacgcat tcttccatat
     7321 cctggcgggc tttccggtga tcaacccgca gggaaaccag aactggcacg acttcgagct
     7381 ctacgtctcc gcgatgacgc aacgcgatct cggcgagttc acccacgcct ggctggacgg
     7441 cacggtgcgg ccgccggact cgctgctgtt tcccgggagc tgaacgacct cgtgagtggt
     7501 gaggacagtg gttctattca ggggtaaggc agaggtgtcg tgatcgcggg cgggtcggtg
     7561 atgaggcgaa ggctcccttc gccgcgtcta atgcggtgaa gggagccttc accccggtca
     7621 cccacccgcg ccgaccccct tggtgtccct tgtggacggt gagccgcgca caacacacca
     7681 cctttgcctt accgcccaaa accgtcctca ccactcacga ggcctgtcca ggtactcggc
     7741 ataaacgggt gccgtccgcg cctcggccca gtacgcgtcg accaccgcgg agagcagctc
     7801 ttcccgccgc cccgccacga aagtctcctt gttccaagcg agaacatgcc tgcgcggcaa
     7861 cacatccccg cgcagcggcc gcgtcacgat gccgtggtca cccgggtcgc agatcggctg
     7921 ggacagcccg atcgcacccg ccttgaccac cagcagcgcc acctgctgcg aagtcacctg
     7981 atgggtgaat ttcggcgtga agccgtgccg cgcgcaggtg tcggcgaagt acttggtgaa
     8041 cgtggccgcc gacgaatcgg acaccatcac ccacgattcg tcccgcaggt cgcgcaggtc
     8101 gacgaccttc tcccgcgcca acgggtgaca ggcgggcagc aggacgaagg tcggctcggt
     8161 caccaccacc gcggtgtcca cgttcgcggg gatttcgagc tcgtagccag gatagtcctt
     8221 gaccagcgcc aattccgcgc ggcgctgggc cagcagcggc aacagccgct cgggatggtc
     8281 gtcgtgcacg acctgcacct cggtgacctc cggccacaac cgggtcacca gcgacggcag
     8341 gcacgccacc agcgcgctgg ccaccgcggc cacccggacg acggcgggcg ggccgctggg
     8401 gcagacgcgc tgctcgatgt cttcgagcag tttgtccagc tgtggcagca aagcggcggt
     8461 gcggcgcaac agcagctccc ccatcggggt cggggtcacg ccgccctcgc accgatcgaa
     8521 tagctggtag cccagcatgt tctccagccg tttgagttgc gcggaaaccg cgggctgggt
     8581 gacgcccagc gcgatcgcgg cacgggaaag gctgcccgtg tccgcgatcg cccggatcac
     8641 ccgcaggtgg tggacatcca gctgtacgac gtcgaactcc tttgtcacga acgggttttc
     8701 gacccgccgg aagaagtcgt ggccgcggga accgccgcgg ccgtggtccg tctgccgaga
     8761 agaacataca gcagaaaagc gccgaaaacg gagttcaccg tggggatccc ccatggcagc
     8821 cagatcccca ccgccgctcc ggccgcccag cagatcagcg cggcgggcac ccaggacggg
     8881 caggtggacg gcagctcccc cgacgcgcgg ccggcctcca gatccggttt ccagcgccgg
     8941 accacgtagt actcggcgat caccaccccc gccaccggcg gcgtgagcac gccgacccac
     9001 gtcaggaagg tggtgaagtg gtcgaggatg ccgatcgcgg agagcaccgt gccgaggccg
     9061 ccgagcagca gcgtcgcggt ggtgcggtcc agccgccggg acagcagcac ctgcacggcg
     9121 ttcaccagcc cgagcgagga cgaatagagg ttccagtcgt tgatcttcag gatcgcggtg
     9181 accaggatca gcgtgccgag caccccggac gacgaggtga tgatcccgac cacgtcggcg
     9241 cttttcgccg cgtgcgcgag cagcaccccg atcaggccga tcaggtattg gccgagggtg
     9301 acgctgacca gggtctgctt caccacgtcg gacgcggtgc ggttgaaccg ggtcatgtcc
     9361 ggcgtcatga tcgcgcccat gatgaaggcg cccgccacca gcgtggtgcc ctgcgccagc
     9421 gacatcgccg ggcccggcgg cggctcggac atcagcgttg gcagcgaatg gtcgccgagg
     9481 gcggagatga tcgaaaaccc cgccagcgcc aggaaagcgg gcaccgtcag atacgccgtc
     9541 caggccatcg cgtggaagcc gaacacgacg atcgcggtga ccagcgcacc gcccgcgagc
     9601 gcccacaccc acaccggcgg gccgcccatc aacgcgtgca gaccgtgggc gaagacgtcg
     9661 ttctgcaccc cgaaccagcc ggccaggctc accgtcatca ggagccccac cagcgacgat
     9721 ccgccggtgc cgaagccggc ccagcgcgcg agcaccgacg tcgaaagccc ttcccgcgtg
     9781 ccggcgaccc ccatcaggat ggtgatgatc tccagcagca cggagccgat cgtgatggcg
     9841 agtaccgcct cccagaacgt catcccgaag cccagcaccg cgccgagcag gaactgatgg
     9901 aacgaggaaa cctgcccgaa ccgttgcagg gcgacggaaa cccaggagta gcggcggtcg
     9961 gcgggcaccc ggcgcaggga gaagtcgtcg tgttccacgc tcactccacc ggttccggga
    10021 cggcttgttc gaggacgacg aaaccttggc ccggcaacgg ccgccacgag agttcgccgc
    10081 ggtagagccg ttcgaggaag ccgacccgct ggtgataggc gaacacggag ctttcgacgc
    10141 cggccacggc gacggtgccg acgaacatcg gcaactcggc gaggaagtac cggaccgcgc
    10201 tgcgcagctg gtcacgagtg gggtgttcgc cttcgggcag gcgccggtcc agcacccagc
    10261 ccgtggcgcc gaggcactgc tcggcgaact ccggatcggt ggcgaaccgg tggtgcgcct
    10321 cggaaagcag gccgagatac gcgctgtcgg cctccagcac cgaggcgtcc agtatcaacg
    10381 tgtgcggatc tgaagggcag acctgctgta gcgcgcggac gatcttgtta cgcgtgtaat
    10441 tcccctgccg ttgcgccttt tgcgcggcgc ggaccgggtc gtaaccgagc gcttcgagcg
    10501 tgaacgcgga cgggccgtcc gggacgaaga aatggaatcc ccgaaaggcc gacatggccc
    10561 agcgggcgag atcggcgata cgttccacgg tgaaatggct gttgaacggg ctgacgccga
    10621 gacaaacgtg ctcggcccgc gccagcggat cggcgcaatg ctccgtgagt ggcagtggtc
    10681 gcggcaagac ggctcctgat tcgcgtgatc tgcaaggcgt cgaccgaacg tagccacggc
    10741 acggtcgtgc gggtattgcc gtcgaatgtt gtcaccgggt tatgagaaat cggctgtctc
    10801 tactttcggg ggtgccgggc gcgaaccggt cgcggtatac gaagtcatgg agattcaggt
    10861 tcggcatctt cgcgtgatct gtgagatcgc cgccgccggc agtctcaatc gtgccgcggc
    10921 cgggctgggg ctcggtcaac cggcgctcag ccaccagttg cgccggatcg agcggatggt
    10981 cggcggcccg ctgttccacc gcgaccagca gggggtgcgg cccaccgaac tcggcgccct
    11041 gatcctgcgg cgggcacgcg cgatcgtgct caccttcgac gaactggagc acgacttcca
    11101 ccgccaggaa cccgagacgg gcgaatcgat ccggatcggc tggaacgaca gcgccatcac
    11161 gggttcgctg ctcggcggcc tgcgcgacct gcgccccggc gagccgttcc gcacgcgcgc
    11221 cgacacttcg cgcacgcggc tgctggcgca ggtcgcgaac cggggcatcg acctcgcgct
    11281 gatcatgatc tgcggccgtc gcggtcttcc ggtaccaccg gaagtgcgga cgctgaccct
    11341 ggtcgaggag ccgtctttcg tcgccatccc cgcggaacac ccgctcgccg gcgaagagga
    11401 gatcgagctc gccgaactcg ccggggagga ctggatcgtg tcgagcggcg gcgacggctg
    11461 ccgggtggtg ttccgggaaa tgtgtctcgc gcacggtttc gatccgcgga tcagccacga
    11521 cgtcgacatc gacaccgtgc gggaagacct ggtcagcggc ggatacgggg tcgggctggt
    11581 ccagccgacc cggccaccgg cggacgggct ggccatccgg ccgctggcgg gcgcgccgat
    11641 gtgcgtgcgg catgtgctcg cgtggcggga agacggtccg tgcgcacgcg gtgtcccgga
    11701 actcgccacc gaggcgaggg cgggctattg gcggctcgcc gaacggacgg cgtcgtaccg
    11761 ctcctggctg caccgccacg gcagggtggc cgccggataa cccctcggca tgccgaggcg
    11821 gcactagagc gtgtcccgcg aggcggccga cgatgtgaat cgtcaatcac ggtcgccgga
    11881 aagaaggggc accatgctgc cgttgatcac ccgtacggaa ctgctttccc ggatggagtc
    11941 cggctcggtg gtcgtggtcg acacgatgcc ggtcgcctat ttcgaaaagg agcatctgcc
    12001 ggaagcgcgc aacattccgg gtttcccgta cgagcaggcc gccgaattca ccgaccggct
    12061 ggcacccacg gtgcttccgg acaagggcgc cgcgatcgtc gtctattgcg cgaacacgcc
    12121 gtgccgcaac agcgaattcg tcggacggcg cctgctggag ctcggataca cgaacgtccg
    12181 caagtaccgc gaaggcatcg aagactgggt cgcgaacgat cttccgacct ggtcttcgtc
    12241 ctgaaaggag atcgtcttgt ccaaggtcaa acgattcgtc tgcgtgctgg ccggtgcgct
    12301 ggcactcgtc accggattcg gcggcggcgt ggcttcggcc gcaccgaagg ccgagaacgt
    12361 gaagacggtg acctcggcca actacgccga ggtcatgaac atctcgaagc agaagctggt
    12421 catcatggac ttcggcgcga cctggtgccc gccgtgccgc cagatgaagc cggtgatcga
    12481 gcggctcgcc ggtgaatacg gcgggcggtt cctgctgggc gaggtcgacg tcgaccagag
    12541 ccgtgacctg tccacccggt acaacatccg ctatctcccg acgctggtcg gcgtccgcaa
    12601 cgccgccgaa ctgccgtcgt cgcggaacat cggttacccg ggcgaagcgc ggttgcgcgc
    12661 ctggatcgac gctcagctcg cgaagggctg accgatgacg tcggagagaa acgcttcgac
    12721 ggcaccgagg taggtctccg gcgcttcgtc gtgcaccacg tgcccggcgc cttggacgac
    12781 gatgtgccgt ccgaggccgc cgggcacacg ggcggccagt tcggcctgct ggccgtgcgg
    12841 catcgcggtg cgttcgccct cgatcgcgag cagcggacac ttgacgcgtt cgacgaactc
    12901 ccagaaatca cgccgtcccc actcggcggc gatctcgtac aggtccgtga gcgacgcgat
    12961 gaggtggtag ccgtcttcgc gttcctcgac gcactcgatg aagtagtcgc cggtgtcgcc
    13021 gaagaactcg cgcacgtggg ccagcgaccg gaacgggacc ggccacgact cgaagtaccc
    13081 gcgccaggtg tccacggtcc ggccgcgctg atccggcgcg aagtcctcgc agaccacggc
    13141 gcggacgagc tcgggatgcg tggccgcggt gacccacgcg tgcaggccgc ccatcgaatg
    13201 tccgatcagg accgcgggtt cgtcgagggt ccgcagcacc tcggcgacgt cgtcggcgaa
    13261 ccgttcggtg cgccagggcc cgccgcgcgg cccgcgcccg tgcccgcgcg cgtccaggcc
    13321 gtggacacgc ccgtacggtt cgagccttcg cgcgacccgc caccacgtcg tcgccctgcc
    13381 catcaacccg tgcagaagga cgatcggcgg cccgtcgccg ccgaaagtga ccaacccgtc
    13441 gcgctgaatc accactaagc tcccctccat gcgcagccgt gtccccgccg ccggtctcgt
    13501 cctgggggtc gtctgcgccc tgattatcgg ctgcagtgcc gatcctcctc cggccacgcc
    13561 ccctccgccg ccgccgatga acccggcgcc gggtgctcct ggcgcgggcg acccgtacta
    13621 cccgatggac ggcaacggcg gctacgacgc gaccgaatac caggtcggga tcacttacga
    13681 ccccgcgaaa gggcgtctcg acggcgacac cacggtgatc gcgaaagcga cccaagacct
    13741 caatcggtac aacttggact tacgcggctt gacggtccaa tccgttgaag tggacgggaa
    13801 accggcgaag ttcgcccgcg agggcgagtt cgagctggtg gtgacacccg ccgagccgat
    13861 ccggaacggg acctccttcc gcacgaaggt cctctacggc ggagaccctt cggcgacgcc
    13921 caaggcgggt ggcagcgaga acggctggca gaagtcgaag gacggcggcg cgttcatcgt
    13981 cggcgagccg cattcggcgt cgttctggta tcccgtcaac gagaccccgc gcgacaaggc
    14041 gatgttcacc ctcaccgccc gcgtgccgga cggctggacc gtcatctcga acgggcgcga
    14101 gatccagaag gccgcggcga acggctggac gacgacgtcc tggcaggagc ggacccccgt
    14161 ggcggcgtac ctgaccacgg tggcgatcga caagttcacc gtcgaccgga tggcgctccc
    14221 ggacgggaca ccggtggtca acgcgtacgc gccgggcgcc gaggaccggc gcgacaccgg
    14281 caggcggctg ccggagatca tcggcttcct gagctcgaag ttcgggccgt atccggtgga
    14341 cgcggcgggc ggtatctatc tcgacgagga catccacttc tcgctggaga cccagaccag
    14401 gccgacctac gcgaaatggg ccgacctgat caccgtggtg cacgaaaccg cgcaccagtg
    14461 gttcggcgat tcggtgacgc tgaattcgtg gtcggacatc tgcctcaacg aatgtctcgc
    14521 ttcgtacgcg cagtggctgt ggcaggagtc gcgggacaac gaggacctgg acgtccgtta
    14581 tcgcgccgcg ctggagatca tgcggggcag cgcggatttc tggaagccga agctggtcgg
    14641 catgggggcc gggcaggaat tccgcggcgt ctacgacaag gggatcctgg ccgtgcacgc
    14701 gctgcggcga aagatcggcg aaggcgcgtt cgcgcggctg ctgaaggaat ggcctgcggc
    14761 gtaccggaac gccaacgcga cctgggcgga cttcgaggcg ttcacgatca agctttcgga
    14821 gcaggacctg cggccgttct tcgacgcgtg gttccacggg acgacgatcc cgccggacgc
    14881 cgaactgctt ccaggcaccc tgcgcggctg acgccaccca cgcatttagt cctctaaatg
    14941 cgggggtagt ccggcaggtc gatgccgttc acgacgtccc gcatcttccg cgaggccagc
    15001 gcggcgaagg gcttcagccg catgacccgc atcgccaggt accgcatccg caagcccgtc
    15061 cgcgatttcg cgaagatcga ctccgcgttc tcccgcccca gctcctgcgt cttctcgacg
    15121 aactcgcgca tgacggcttc gtagcgcttc agcccggtgt cgagaccggc ggcgagttcc
    15181 ccggcgagca cgtacgcgcc gacgaacgcc aggctcgtgc cctgcccgga cagcggcgac
    15241 gggcagaaag cggcgtcgcc cagcagcccg acacggcctc gcgaccagga gtccatgatc
    15301 acctgggcgc acgagtcgaa gtagaagtcg ggcgcctcgt ccatccggtc gagcagccag
    15361 ggcgcctccc actccatccc ggcggcgaac cgccggacca gcgccttctg tgcctcgacg
    15421 tcgcgatagt cgtagtcgat tttcggcgaa gcgaacccga agtacgccat cgcctcgtcg
    15481 ccgtcgcgga cggcacggat cccggcggac cggccgacgt cgtcgtagcc gacggcccag
    15541 ttccgcaggc cgagccggtt cggcacggtg aagaacgcca ggtacgaacc cagatgccgg
    15601 acgaaccgcg actcctcgcc gaaggccagt gcccgcacgc ccgaatgcag cccgtccgcc
    15661 ccgatgacca ggtcgaacgt cgccctcgaa ccactcgcga aggtgacgcc gacaccgtcg
    15721 tcccgctcgt ccagcgcggt gatccggtcg ccgaagacgt actccgtccg ctctttggtc
    15781 gcttcgtaga gcacttcggt caggtcgccg cggaggatct cgatctccgc gacgacaccg
    15841 tcgccgtcga agtcgtcggc gcggatggtg gccttcgtgc ggttcttccg gtcgacgagc
    15901 gtctcgccct tcgtgtccgt gcaggccgcg cggatgcgtt cgtccagccc catccggcgg
    15961 gcgacctcct tggccgttcc gcgcaggtcg acggcctggc cgccggggcg caacgacggc
    16021 gcgcgctcca cgacggtcac ctggaagccg taccgggtga gccagaaggc caaggccggt
    16081 ccggcgacgc tcgctccgga gatgaggatc ttggtgtcag ccatcgtctg gaaggtccca
    16141 cgcatcacat cgcggcgcaa aaggatttcg tcgtaggctg gcggcatggc tgtcgtgaag
    16201 atcaacgcga tcgaggtccc cgaaggcgct ggccccgagc tggagaagcg gttcgccgcg
    16261 cggctgcacg ccgtcgacaa ccagcccggc ttcctcggct tcgagctgct ccgcccggtc
    16321 tccggcgagt cgcgctactt cgtctacacc aagtgggagt ccgaagaggc gtaccaggcg
    16381 tgggcgtccg gcccggcgcg tgaggcgcac gcgggcgagc gcgcgaagcc agtctccacg
    16441 ggtgcgaacc tgctggaatt cgaggtcgtc caggcttcga agccgggtga gtgaactcga
    16501 acgagccgcg gaactgatcg acggcgccgg cgcgctgctc gtctgtgccg gcgccgggat
    16561 gggcgtcgac tccggcctgc ccgatttccg gggcgatgaa ggtttctgga aggcgtatcc
    16621 gccgtatgag cggctgggca tcagcttcgt cgagctcgcc gaccctcggc atttcgccga
    16681 agatcccgag ctggcctggg gtttctacgg gcaccggctc gcgctgtacc gcgccaccgt
    16741 gccgcacgac gggttccggc tactgctgtc ctggggagca cggaaaccgg gcggcacccg
    16801 cgcgttcacg tccaatgtgg acggacaatt ccagaaggcg ggttatccgc acgtcgccga
    16861 ggcgcacggc tccatccatc atctgcagtg cctcgacagg tgcaccaagg agatctggcc
    16921 cgcggacgac gtcgaggtcc cgatcggcga agacaccatg cgcgcgcagg cgcccttgcc
    16981 gtcctgtccg cgctgcggcg gtctcgcccg gcccaacatc ctgatgttcg gcgactacga
    17041 ctggctcggg cagcgcagcc aggcccagct cgacgagctg aacgcgtggc gccgcgcgca
    17101 tcgcgacctc gtggtggtgg aactcggcgc cgggcaggcc gtgccgacgg tgcggcggta
    17161 ttcggagctg gccagcgccg cgaccggcgc cctggtgcgg atcaacccgc gtgaacccgg
    17221 gatccggcac ggccgcggcg tttccctcgc gaccaacggc ctggaaacgc tcgaagcgct
    17281 ggacgccctg ctcagctagg cccaggtcct tgccttccgg tctcggggtg gatgaagggg
    17341 actttcaccg catgcgacgc gggtaaagcg cccttcaccg cgtgggtgag ggaccgtgcc
    17401 atgaacatcc acaaggtgca cctgaaccgg cgacaccgtc caggtcgcgc ccgcgtcacc
    17461 cgagcgcgct ctccggggcg cccgcgggca gctgtcccgg gacacaggcc gcgagcagcg
    17521 acaaggccag aattccccag agcttcctca tcagcgggaa gcctgccagc ggaaggtcac
    17581 tttccgggca ggacgatttc cgcgtagacg gcgtcgtgat cgctccccgg cgtctccagc
    17641 accttgaagt ccgcgatggc cgtccgtttg tccgccagca cgtggtcgat cgccaccggc
    17701 ggcgcgatcc cgttcgtcca ggtcccctgc aaggccttcc ccagctcatc ggccgcgtcc
    17761 acgtatcccc tggtcagcag ctcgcggaag agcgcgtggt cgaggctcgc gttgaagtcg
    17821 cccgccagga tcctgatgtc gtgctcggcg tcggcgtacg gcaggtcctt ggcctcggcg
    17881 acccactcgt accggtccca catcggcgcc gacggatgga ccgcgacgac ctcgacgcgg
    17941 acgccgtccc ccagatccac gctcgcgctc ggctgcttgt gatccgagtc gccgctcagc
    18001 ttcaacggcg tgagcgggta cttcgacacc agcccggagc cggacgccca ctcggccgga
    18061 tgcagcacgc ggtacggcag gacctggaac agccccgccc ggtcgagcgc ggtgatcgcc
    18121 tcgggggtca gctcggtcag gctcaggacg tcgacctggt gttccttcac gtagccgacg
    18181 atcctgtccg gatccgcccc gccgccgagc atgttcgacg ccaggacgcg gacgtgcttc
    18241 ccgtcgagcg ccttctgctc gttcgcgaac gcgcgcggca ggaccatcga cgcgatcgtg
    18301 caggtcagcg ccagtgcgac gaccgcggtc caccagcgcc gcaggcccag cgcgaggagg
    18361 ccgagcacga gcgtcgcgat cccggcgtac ggggtgagcg cgagcgccgc gatcgtgtac
    18421 gtgttgccgt cgtagccgac cagccgcagc gcggtcagca ccgcgaacgg aacgaccgcc
    18481 gcgatgagga tcccgccggc cagcttccgt ccggtgccgg gacgcgccgc cggacgaacc
    18541 ggacgttctt cgatcaccat gccgtcgagt atgccgatca cgcgcgccgg ggcggcggtc
    18601 tccacaacac cttcacaacc tcctcacacg gcgtctacca gcgcttatca gcccctgtca
    18661 gccgctgcca gcgcgctgtg cgcggtctgc caggcccggg gtgcaccttt gtccgcgggg
    18721 cgagatccac aggaggaaag cgatgactca cgcgatcagg gccgagggcc tggtcaaaca
    18781 ctatggggag acgaaggcgc tcgacggggt cgatctggag gtcccggcgg gcaaggtggt
    18841 cggggtgctg gggccgaacg gcgcggggaa gacgaccgcc gtccggatcc tggccacctt
    18901 gatccggccg gaccgcggcc acgcgagcgt cttcgggtac gacgtcgtca agaacccgat
    18961 ggcggtccgg agcatgatcg ggctgaccgg gcagtacgcg tcggtcgacg aggacctttc
    19021 cggtacggag aacctcgtcc tgatcggcag gctgctggag ttctcgaggg cggacgcgaa
    19081 gcagcgcgcg gccgaactgc tggagcggtt cgagctgacc gacgccgccg gccgcgcgat
    19141 caagacctac tcgggcggga tgcggcggcg gctcgacctc gccgcgagcc tggtcggccg
    19201 tcccaaggtg ctgtacctcg acgagccgac cacgggcctc gacccgcacg cccgcaacga
    19261 ggtctgggcc gtggtccgga cgctggtcgc cgacggcacg acggtgctgc tcaccacgca
    19321 gtacctggag gaggccgacc agctggccga cacgatcacc gtgttcgacc acgggcacgt
    19381 cgtggcgaac ggccgggccg acgagctcaa gcggcggacc ggcggccaga cactgcaggt
    19441 gcggccgtcc gcgctcgccg acctcgacgc cgtcgagcgc atcctggccg ggctcaccgg
    19501 ggtccggccg aaccgggacg acgacaccgg gctgctcacc gcgcccgtcg ccgatcccgt
    19561 cctgctgtcc actttggtcc gcaagctgga cgaagccggg atcaccgcgg acgagctggc
    19621 gctgcggctg cccagcctcg acgaggtgtt cctcgcgctg accggcaaga agaccgacga
    19681 gtccacaaag gacactactc cggaagggag cctggtatga cgaccatcgc cgcgcccgca
    19741 ccacggcgcg tttcactgtc gagcagcacg cggcacgggc tttccctcgc ctggcgcggc
    19801 gtgctgaaga tccgcaagaa cccggagcag ctggccgacg tcacgctcgc gccgatcatc
    19861 ttcctggtca tgttcgtcta cctgttcggt ggcgcgatca tgggcagcac cgagagctac
    19921 ctccagatga tcgtgcccgg catcatggtg ttcaacatcc tgcaggccag catgaccgtc
    19981 ggcgtccagc tgaacaccga cgtcaccaag ggcgtgttcg accggttccg cgcgatgccg
    20041 atcgcccggt ccgcgccgct gatcggcgcc gtgctggccg atatcgtgcg gtacctggtg
    20101 tgcctggtcg tgctgatggt cgtggcgacg atcatgggct accggatcca gaccggcccc
    20161 gccgagttcg cgctggcgat cctgctcgtc atcgcgttcg cgctgtcgtt ctgctgggct
    20221 tcggtgttcg tcgggatgct ggtgaagagc cccggcgcgg tgcagggcct gatgttcgtg
    20281 gtgctgatgc cgctgacctt cggcagcaac gtgttcgtgg ggacgagcac gatgcccggc
    20341 tggctgaagg cgtgggccga catcagcccg gtgacacaga tgtccgacgt cctgcgcggg
    20401 ctgatgaacg gcggaccgat cgccggcccg ctgaccgggg cgctgatctg gatggcggcc
    20461 gcgctcgcgg tcttcttccc gctcgccact tgggcctacc ggaagcgcgt ctgactccgg
    20521 gtcaggggga acgcgcgtga agggctcctc gccactgccg ggcgaggggc ccttcttcac
    20581 gcgcccactt cccgcaggat ccaggacatc aggtcggccc gggacagccc ggcgtcctgc
    20641 acgagcaacg cttcgtagcg ctcttcgccg aatcgcccgc gcagttc
//
