LOCUS       NC_021252              22026 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7483026
            Orig. end                         :: 7505052
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22026
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="28"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22026
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22026
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12026](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12026
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    complement(128..142)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
     gene            complement(288..2342)
                     /locus_tag="AORI_RS74465"
                     /old_locus_tag="AORI_6689"
     CDS             complement(288..2342)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150523.1"
                     /locus_tag="AORI_RS74465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6689"
                     /product="hydantoinase/oxoprolinase family protein"
                     /protein_id="WP_016336976.1"
                     /transl_table=11
                     /translation="MTGLRVGVDIGGTFTDLCVLDETGVVAVGKVLTTHDEPARAVEEG
                     LKRTLADAGLDAGDVEQFVHGTTLVTNALIERKGARTALLATAGFRDVLEMRREHRYEL
                     YDLLIELPDPLVPRHLRFDVPERILADGYVHTGLDEEYVARLGRELDARGIDAVAICFL
                     HAFTNPVHERRAAEVLREVAPRLRVALSSEVVPEIREFERASTTVANVYVQDLTERYLR
                     DLERRLHEAGVRPSPHIMLSNGGIATVDTAARHPIRILESGPAGGALAASAIGAAAGVG
                     DLLAFDMGGTTAKLCMISGGAPLVTHEFEVDRKYRLLPGSGLPVKVPVTDMIEIGVGGG
                     SIARIDALGLLTVGPDSAGSEPGPVCYGRGGTEPTVTDADLVLGYLDPGYFLGGGMTLD
                     AEGAREAIRSKIAGPLGVSVEEAAWGIHTSVNEDMANAARVHAVERGKDPAKLPMFTFG
                     GAGPVHGVGVARALDAPEVVAPPAAGVLSAAGFLTAPLAFDFVRSARSAVLDLSWDQVD
                     ALFAEMEAEGAELLRKSDVEDVTHRRIAEMRYSGQGYEIRVPVERGNWPESLIGAFTET
                     YRALYRRTGPDVGIEVLNWRVVSSGPAPEVTLKLAGAKAEGDARKGSRPAYFPTAGGFV
                     DTAVFDRYRLKPGDRVDGPAIVEERESTVVVPPGARCVVGEDAGLVVTV"
     gene            complement(2339..3970)
                     /locus_tag="AORI_RS74470"
                     /old_locus_tag="AORI_6690"
     CDS             complement(2339..3970)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028451.1"
                     /locus_tag="AORI_RS74470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6690"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_016336977.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-55, bitscore:
                     186.6, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-26, bitscore:
                     91.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPTGAQHLADALTALGTEVVFGLPGVHNLPLWEALADTDIRLV
                     GVRHEQTAGYAADGYARATGKLGVALVTTGPGAANTLAAVGEAMASAAPVLIIATDIPS
                     TLRRHGVVRGVLHETSDQQAMFAPVTKAGFTVTSADQVAATLHRAARLALQPQSGPVYL
                     GIPTDFLSERTPARRPPRSHARPAEIPDLTEAEALLAAADRPLIWAGGGALRAEAGEAI
                     GKLAERLAAPVLTTFGARGLLSVDHPCLAPNPVHAPEVGALWDEADVVLAIGTDFDGLM
                     TQNWLMPRPKKLIAINVDPDDAAKNYQPDITLVGDARVLVEALKVEERSGIAALVGRLA
                     KVSARVRQRIKEEEPQAADLLSTLDEVLPPDAVVVADMCVAGYWIGGFHRVRAPRKLAY
                     PMGWGTLGYGFPAALGAGAAGGGRAICVTGDGGFLFGCGDLHTLAQEQLPVTTIVVDDG
                     GYGMLRYDQDRAGLPRRGVDWDSPDFVGLARSFGVHADRVSGFGRAFRRLLGEFVESDE
                     PNVLVVRAKMAPPLNTSPRWYRKESP"
     misc_feature    complement(3872..3874)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4259..4882)
                     /locus_tag="AORI_RS74475"
                     /old_locus_tag="AORI_6691"
     CDS             complement(4259..4882)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033792.1"
                     /locus_tag="AORI_RS74475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6691"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_016336978.1"
                     /transl_table=11
                     /translation="MSEFVEVTTEAELREILPPPLERTANKARPKLHELDRQWLAESPF
                     VLIATSAADGTCDVSPKGDPAGFTLVLDDTRIAIPERPGNRRADGFHNVLSNPHVGLIY
                     LIPGRGDTLRINGRARLVREAPFFDDMIVKGNRPKLALVVDIDEIFHHCQKAFMRSKLW
                     SPESWTPGALPSRAAISKTFERPEESMADLEAYYEPGRYAAGLY"
     gene            complement(4875..6032)
                     /locus_tag="AORI_RS74480"
                     /old_locus_tag="AORI_6692"
     CDS             complement(4875..6032)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150529.1"
                     /locus_tag="AORI_RS74480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6692"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_016336979.1"
                     /sec_met_domain="DAO (E-value: 3.8e-68, bitscore: 229.5,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLPERTDVVVIGGGIIGVACAYRLAAAGVSVLLLERDTLGAGS
                     TAKAAGGIRSSFTTRVNIEIGLRGLAEYASFAETYGTEIDFRRDGYLYLVTDPADLPEF
                     ERCAELQNSYGVRSRLVEPAEARRFSPLIDTEGVVAALWSPDDAKATPDSAVQGYARAA
                     RGHGAVLKTGVEVVGIERDGDEITGVRTSAGFVRTDAVVCAAGAWSGRIGELAGVELPV
                     RPYRRQVVFTGPVTDLPERVPLTIEMPSAFYFHREGLGLAMSFCDGDGDPGFDTRYQPG
                     EWLPKLAEIAARRVPAVLGAGIRGGWAGLYEVTPDRNQIVGESVHLSRFFYATGFSGHG
                     FQMGPAVGELVRDLYLGRVPAIDITGLDVRRFAGDRAVTREHNIV"
     gene            complement(6016..7026)
                     /locus_tag="AORI_RS74485"
                     /old_locus_tag="AORI_6693"
     CDS             complement(6016..7026)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GST_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033794.1"
                     /locus_tag="AORI_RS74485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6693"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_016336980.1"
                     /sec_met_domain="GST_C (E-value: 1.4e-07, bitscore: 30.5,
                     seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPTDPQTGEFRRSANHFDARVTADGRDGWPVEAGRYRLVVSRA
                     CPWASRGLIVRRLLGLESALSVAVADPIQDEKSWRFTLDPGDRDPVLGIKYLAEAYHAA
                     DPHYMGGISVPAIVDIPSKRLVSNDYPQITLDLSTEWTSFHRPGAPDLYPERLRGEIDD
                     VNAGVYADVNAAVYQAGFATKQAAYEDAYTRLFTMLDVLSERLEKQRYLVGDTITEADI
                     RLFTTLVRFDAVYHGHFKCNRNKLAEMPVLWAYARDLFQTPGFGDTVDFDHIKRHYYAV
                     HEQVNPTRIVPLGPDLSGWTPHHREQLGGRPFGDGTPPGPPPEDERIGDTDGVTA"
     gene            7123..8499
                     /locus_tag="AORI_RS74490"
                     /old_locus_tag="AORI_6694"
     CDS             7123..8499
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008374 - O-acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150531.1"
                     /locus_tag="AORI_RS74490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6694"
                     /product="wax ester/triacylglycerol synthase family
                     O-acyltransferase"
                     /protein_id="WP_016336981.1"
                     /transl_table=11
                     /translation="MPFMPVTDSMFLLVETREHPMHVGGLQLFKKPEGAGPDYLRDIRK
                     SMLESDNMRSVFRRRPARPVNTAGHLAWSTDTDLELDYHFRHSALPQPGRIRELLELTG
                     RWHSTLLDRHRPLWEIHLVEGLQDGRFAIYSKIHHALMDGVSALRHLQGTLSDDPADLD
                     CPPPWGRRAKPDGGRNGKASPSVLSAFGKTVNQLAGIAPAAMKVAREAFQEHTLTLPAQ
                     APKTMLNVPIGGARRFAAQSWSLDRVRKVATAAGVSRNDVVLAMCSGALRDYLIEQNAL
                     PDAPLTAMVPVSLRRKDSGDAAGNNIGALLCNLATHLTDPAARLATINASMRNGKKLFS
                     ELTPLQTLLLSGINVAQLGISPIPGFVNNTKPPFNLVISNVPGPRKQMYWNGAALDGIY
                     PASVLLDGQALNITLTSNGDNLDFGVTGCRRSVPHLQRILTHLDTALVELEHAVSLPRV
                     "
     gene            complement(8553..9539)
                     /locus_tag="AORI_RS74495"
                     /old_locus_tag="AORI_6695"
     CDS             complement(8553..9539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631253.1"
                     /locus_tag="AORI_RS74495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6695"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_016336982.1"
                     /transl_table=11
                     /translation="MSLRRILAATFAAATAVSIAAVPAAAETPPSAQAIRQLASGLNQA
                     WSIDFLPDGTGVFTQKDAKTISKIDKAGKVTTVQTIPGVSVTAEAGLLGIAVSPKYATD
                     ETVFIYYTTSSDNRIAKLKLGQPPTPIVTGIPRGSQYHHGGRIRFGPDGYLYAGTGDGQ
                     NGANAQNKNSLGGKVLRVTTDGAAAPGNPFNSRVYSYGHRNVQGLTWANGQLYISDIGA
                     NKLDELNKIEPGKNYGWPTCEGPCNTAGMTNPVKSWPTSSATPSGLAAYKGSLYMASLK
                     GGTYKLDLNGNGGKLWTNLGRTRDATAGPDGQLYTITPGGLYVSDGS"
     misc_feature    complement(9531..9533)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9704..9722
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.01"
                     /tool="antismash"
     misc_feature    complement(9708..9720)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.4"
                     /tool="antismash"
     gene            9820..9915
                     /gene="pqqA"
                     /locus_tag="AORI_RS74500"
     CDS             9820..9915
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033797.1"
                     /locus_tag="AORI_RS74500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_043848360.1"
                     /transl_table=11
                     /translation="MTETIEVWTTPDFVEYETPMEVTAYAARMED"
     gene            10001..10681
                     /gene="pqqC"
                     /locus_tag="AORI_RS74505"
                     /old_locus_tag="AORI_6696"
     CDS             10001..10681
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631254.1"
                     /locus_tag="AORI_RS74505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6696"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_043848361.1"
                     /sec_met_domain="TIGR02111 (E-value: 6.4e-85, bitscore:
                     283.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSEFIAALRGLSHRYWGTHPFHVRMHNGELSEYELKIWAANRW
                     YYQCVLPQKDAAIISNCPLPEIRREWLDRIVYHDGAKAGDGGIERWLRLCTAVGLDREE
                     VLDQRHVAPGVRFAVDAYVTFARTKPWLEAVASGLTEMFAGHLMQRRVADMLANYSWIA
                     PEDLAYFTNRIDKVSGEGKGTLDIVVRHAVTREQQEKAIAALSFKTDVLWSMLDAIERA
                     AAKE"
     gene            10684..10956
                     /gene="pqqD"
                     /locus_tag="AORI_RS74510"
                     /old_locus_tag="AORI_6697"
     CDS             10684..10956
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="AORI_RS74510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6697"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_016336984.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.8e-23, bitscore:
                     79.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2e-10, bitscore: 39.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTLDLGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAV
                     LSLCDGVGDVAAIASALRERYAGVREEEILDVLSRLGDRRIVEWT"
     aSDomain        10687..10947
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_AORI_RS74510_PqqD_RRE.1"
                     /evalue="1.30E-25"
                     /identifier="RREFam006.1"
                     /label="AORI_RS74510"
                     /locus_tag="AORI_RS74510"
                     /protein_end="88"
                     /protein_start="1"
                     /score="79.9"
                     /tool="antismash"
                     /translation="TTLDLGSVPRLRRGVRLSYDQTRETHVLLFPEGVLVPNPTAAAVL
                     SLCDGVGDVAAIASALRERYAGVREEEILDVLSRLGDRRIVE"
     gene            10947..12026
                     /gene="pqqE"
                     /locus_tag="AORI_RS74515"
                     /old_locus_tag="AORI_6698"
     CDS             10947..12026
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150538.1"
                     /locus_tag="AORI_RS74515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6698"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_016336985.1"
                     /sec_met_domain="PF04055 (E-value: 5e-22, bitscore: 77.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.2e-06, bitscore: 24.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.4e-08, bitscore: 33.2,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.5e-10, bitscore:
                     39.5, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLNTAAPLGMLAELTHRCPLHCPYCSNPVELIARDGELSTEEWI
                     SVLSQARELGVLQVHMSGGEPLARPDLPILVEHATKLGCYVNLVTSGLGLTESRLDDLV
                     ERGLAHVQLSVQGATADRADRLAGARAHDRKLVTAELITKAGLPLSVNVVLHRQNHDQL
                     AGIIDLAEKMGADRLELANTQYYGWALRNRDALMPTRRQLEEAEPIVRAATDRLRGRME
                     IIYVVADYYEQYPKPCMYGWGARQLTVAPDGNVLPCPASTAIETLEFDNVRDKPLAWIW
                     YESASFTAYRGEDWMSDTCGTCERRAIDFGGCRCQAFQLTGDPTATDPVCSRSPHRGVV
                     DLILATPTKTDELVMRAPR"
     gene            12023..12886
                     /gene="pqqB"
                     /locus_tag="AORI_RS74520"
                     /old_locus_tag="AORI_6699"
     CDS             12023..12886
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631257.1"
                     /locus_tag="AORI_RS74520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6699"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_016336986.1"
                     /transl_table=11
                     /translation="MRVILLGTAAGGGFPQWNCACALCVSDAPPRTQDCVAVSADGEGW
                     YLLNVSPDIRAQILATPPLRAGPGPREIPLRGVLLTDAELDHSLGLLLLREAGGLPVWA
                     PDAVLGALSEQFPARAIIDGYGGWEWLPSSDVSIDGLRVSMLPVSDKRPKYARSSTEDG
                     PWVVAYRIEDVQTGGVFVYAPCLKSWPDGFDDFTRDAGLVLLDGTFYAPDEMSGATAAE
                     VGDGAQLAMGHLPITGSLAKLRPGPRWVYTHLNNTNPVIDPASPEHAAVLAGGASLPLD
                     GTEFKL"
     gene            complement(12883..13857)
                     /locus_tag="AORI_RS74525"
                     /old_locus_tag="AORI_6700"
     CDS             complement(12883..13857)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082804.1"
                     /locus_tag="AORI_RS74525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6700"
                     /product="aldo/keto reductase"
                     /protein_id="WP_046199858.1"
                     /transl_table=11
                     /translation="MRTTTLGRSGLEVSRIAFGTWQLGGDWGSFDEDTAIAAIHHAREL
                     GVNLFDTAQAYGFGKSEAMLGKALREELKRDRDNLVIATKGGIKPRSERPRDSRREWLT
                     QGVEDSLRFLDVDHIDLYQIHWPDTDAPAEETAGILQEFVDAGKIRHVGVSNYDAAGLA
                     AFDETRPVETLQPPYHLFRRDIETDPLPYARENDIGVLVYSPLGSGLLTGAFTPETTFE
                     KTDWRSRSSAFTGDTFLRNLAVVDRLKEFAAGKGISVSQLAIAWTLAQPGVHVAIVGAR
                     KAANVEASLAAADIDLSADELAEIDRLTADAVPVSGASPEGVA"
     misc_feature    complement(13918..13931)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            13965..14483
                     /locus_tag="AORI_RS74530"
                     /old_locus_tag="AORI_6701"
     CDS             13965..14483
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033803.1"
                     /locus_tag="AORI_RS74530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6701"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_016336988.1"
                     /transl_table=11
                     /translation="MSESPSLDGLRVLAHPLRLRILSLLTGVAMSAAEAARELGETQAN
                     VSYHVRRLHEAGLLDVAEEVRIRGGLAKRYRHDPESGMRFTSKHPDEEQLLIAAMVEEL
                     KRRSEFRLPDERGSISDAEMWVDRETWEKALEHARELSDLLHSAAKPPRTRGTIPVSAT
                     VAMFEMRRP"
     gene            14480..15700
                     /locus_tag="AORI_RS74535"
                     /old_locus_tag="AORI_6702"
     CDS             14480..15700
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150544.1"
                     /locus_tag="AORI_RS74535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6702"
                     /product="MFS transporter"
                     /protein_id="WP_016336989.1"
                     /transl_table=11
                     /translation="MTTLREPLRHHNFRWLIAGRTFGEFGNAVAPLALAFAVIDLTGSA
                     VDIGIVVGARSVASVVLLLFGGVLADRLPRSVILQGTEVAATLTQAVIAASVLCGFASI
                     PLLVALSVVNGAVAAISAPASASLTPLTVPATQLAQANALARLLSNSGRIAGAGLGGIL
                     VTAVGPGWALAGNALLFLGSALSYRCIRLNRRERVPGSRPLAELAEGWREFRSRTWVWV
                     VVVQFMVVNAVIAGGIAVLGPVVADSTFGRSGWGFALAAQTIGSLVGGILVARWQPRRA
                     LFVGVAVILLEAPPLILLGQAPLLPLLLAAMFVSGLAIEQFVVAWDVSLQENVPEDKLA
                     RVYSYDMLGSFIALPLGQMAAGPAAHHFGVSTTLLACAALVVAATCLALCSGQVRGLVR
                     KTHAAQP"
     gene            complement(15752..17128)
                     /locus_tag="AORI_RS74540"
                     /old_locus_tag="AORI_6703"
     CDS             complement(15752..17128)
                     /EC_number="3.5.1.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005150551.1"
                     /locus_tag="AORI_RS74540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6703"
                     /product="amidase"
                     /protein_id="WP_016336990.1"
                     /transl_table=11
                     /translation="MNDTKLTASELVAAYATGELSPVEATQTALRAIEERDGETNAFCL
                     VDADGALEQAKASEVRWRDGNPIGWLDGVPASIKDMFLTQGWPTLRGSRCIDPDQPWDV
                     DSPVTARLRENGLVLLGKTTTPELAWKGVTDNTLTGITRNPVDPSTTAGGSSGGSAAAV
                     AAGMGELSVGTDGGGSIRIPASFCGIVGLKPTHGRIPLFPASPFGPLSHAGPMARSVDD
                     TALLLDVLAMPDYRDPAALAPPVSTYREAVRRDVRGLIAAYSPTLGYVDVDPEVAEIVK
                     SAVQSLGDAGLHIEEADPGFADPKPAFDILWSTGAAKWLDTFPAGSETKVDPGLRKVWE
                     LGKTFSASDYLGANAERAALGILMGEFHTRYDVLITPTLPIPAFEAGHEVPPGSGLSGW
                     PDWTPFTYPFNMTQQPAISVPAGRTSSGLPVGLQIVGPRHSDDLVLAVAKLLEEVRPWP
                     "
     gene            complement(17137..18126)
                     /locus_tag="AORI_RS74545"
                     /old_locus_tag="AORI_6704"
     CDS             complement(17137..18126)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336991.1"
                     /locus_tag="AORI_RS74545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6704"
                     /product="D-2-hydroxyacid dehydrogenase"
                     /protein_id="WP_016336991.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 5.5e-49, bitscore:
                     164.8, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIASETPVLAVLCGDTRPPDMRAIEAEAVVRYTDAAGLADALSGA
                     DAFFVYDFLSTAVPGAWHAADRLRWLHIASAGVDPVLFPGLQESDVVLTNSRGVFDGAI
                     AEYVLGVVLTFAKDFARSWDLQKQRQWKHRESERISGRRVLVVGTGPIGRSIARMLRAA
                     GMSVAGVGRRPRAGDPDFGDVYASSELSRHLPGADYVVAVAPLTEQTKGMFDAEAFGVM
                     KPGSRFVNVGRGELVVTSDLIGALRDGPLGGAALDVFDTEPLPAESPLWTMENVLISPH
                     MSGDFVGWRNTLVEVFADNFRRWRAGEALRNVVDKQLGYVPSETLRQG"
     misc_feature    complement(18001..18003)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            18227..18967
                     /locus_tag="AORI_RS74550"
                     /old_locus_tag="AORI_6705"
     CDS             18227..18967
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631263.1"
                     /locus_tag="AORI_RS74550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6705"
                     /product="maleate isomerase"
                     /protein_id="WP_016336992.1"
                     /transl_table=11
                     /translation="MDFDLLEFEGPLAQRGIGVIAPFDLALERELWRWVPMEVSLHLAR
                     TPYEPVPVSMEMAQLVSDSRHLAAATRDVLHVEPEVVAYLCTSGSFVNGVDYERSLTKA
                     ICDAGATDAVTTSGALAEVLHQLDLHRVSVLTPYDGDLTGKLHDFLAELGVRTVSSDHL
                     GLGGGIWKVSYRTIAERILAADHADAEAIFVSCTNLPTYDLIEPLESALGKPVLTANQL
                     TMWACLRRMNLPIVGPGKWLREVD"
     misc_feature    18239..18241
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19012..19782
                     /locus_tag="AORI_RS74555"
                     /old_locus_tag="AORI_6706"
     CDS             19012..19782
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033808.1"
                     /locus_tag="AORI_RS74555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6706"
                     /product="arylmalonate decarboxylase"
                     /protein_id="WP_016336993.1"
                     /transl_table=11
                     /translation="MPITPFAPPEPPSETTTIGFIYPDHAAEDDYPLAEQLLGGDMAGI
                     KLPVEHIYGTDLHAVPELLDLGSESRLADGAALLAKHEPDAVVWACTSGSFVYGWEGAR
                     DQADRLAAVAGVPASSTSFAFVNAARALGVRRVAVAASYPDDVARLFVEFLGAGGIEVV
                     SMGSADIDTAAEVGDLSPEAVVELAVSRDHPAADALLVPDTAMRTLGEINTLETRIRKP
                     VLTANQVTVWEGLRLTGKSPLVRTLGALFGQRRS"
     gene            19786..20478
                     /locus_tag="AORI_RS74560"
                     /old_locus_tag="AORI_6707"
     CDS             19786..20478
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033809.1"
                     /locus_tag="AORI_RS74560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6707"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_016336994.1"
                     /transl_table=11
                     /translation="MSLPDIEPVSRESTAGIIARQLRDAIMTGALPPGTQLGETDLASR
                     FQVSRGPLREAMQHLVSEGLLRSERHRGLFVIDLEPGDVYDIYSARSAIERAAMLRALR
                     GDRERVATELEEAVRAMAAAADEDDPTALSWADLRFHEALIAASGSKRLVRMARTLLIE
                     TRMCLTALQGTYQQVEERVTEHTSIIEALRAGDEETALSLLEAHMEDAVQRLAPGTSLR
                     EGEAPAVP"
     gene            complement(20483..20959)
                     /locus_tag="AORI_RS74565"
                     /old_locus_tag="AORI_6708"
     CDS             complement(20483..20959)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033810.1"
                     /locus_tag="AORI_RS74565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_6708"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_016336995.1"
                     /transl_table=11
                     /translation="MCWHCDNPGKTRDDYLVEEVRPLIRKYGWMVQTVERGIVQPGFAY
                     TVGLTDAGLPELVVTGLRERRSGQLLNYFAQQVVRSGPPEPGEVLPAEVGWPSLEVVPL
                     SSPSAHLLTAVLLYGENFRALQLVYEDEHGNWPWDREFRGGTGGQPVLGARGRG"
     misc_feature    complement(21102..21116)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.24"
                     /tool="antismash"
     misc_feature    complement(21531..21542)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     misc_feature    complement(21552..21566)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 22.4"
                     /tool="antismash"
     misc_feature    21998..22012
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.7"
                     /tool="antismash"
ORIGIN
        1 ggtctgccac gggtcgttgg tgagcaggac gtcgcccggc gccaaggtct ccggtggata
       61 cgcggcgacg aagtggtgca tcccggtcgc catcgcgttg atgtggccgg gggtcccgcc
      121 gacggactgg ccgatcatct caccgcgcga gtcgaacacc gcgcaggcca gatcgagcga
      181 ttcccgcacc acggacgaga aagccgtgtt gacgagcgcg ttctgttgct ccgccaggat
      241 cgagtgcagc cggttcccca gcagacccac caggatcggg tcgacgctca taccgtcacc
      301 accaggccgg cgtcttcgcc gacgacgcag cgcgcgcccg gcggaacgac cacagtggac
      361 tctcgttcct ccacgatggc gggcccgtcg acgcggtcac cgggcttgag ccggtaccgg
      421 tcgaacaccg ccgtgtcgac aaatccaccc gcggtgggaa agtaggccgg gcggctcccc
      481 ttgcgcgcgt cgccctcggc cttggcaccc gccagtttca gcgtgacctc gggcgccggc
      541 ccgctggaga cgacccgcca gttgagcacc tcgatcccga cgtccggccc ggtccgccgg
      601 tacagcgccc gataggtctc ggtgaacgcg ccgatcagag attccggcca gtttccccgc
      661 tcgaccggca cgcggatctc gtagccctgc ccggaatacc gcatctcggc gatccggcga
      721 tgcgtcacat cctccacatc ggacttccgc agcagttccg cgccctcggc ctccatctcg
      781 gcgaacaagg cgtcgacctg gtcccaggag agatcgagca ccgccgaacg cgccgaacgg
      841 acgaagtcga aggccagggg cgcagtgagg aatcccgccg cgctcagcac ccccgcggcg
      901 ggcggtgcga ccacctcggg cgcgtcgagc gcccgtgcca cgccgacacc gtgcaccggt
      961 ccggcgccgc cgaaggtgaa catcggcagc ttcgccggat ccttgccgcg ctcgacggcg
     1021 tggacgcggg cggcgttggc catgtcctcg ttaacactgg tgtggatacc ccaagcggcc
     1081 tcttcgacgc tgacgccgag cggccccgcg atcttcgagc ggatcgcctc acgcgcgccc
     1141 tcggcgtcca aagtcattcc gccgccgagg aaataacccg gatccaggta gccgagcacg
     1201 aggtcggcgt cggtcacggt cggctcggtg ccgcctcgtc cgtagcagac cggccctggc
     1261 tcggacccag ccgaatccgg gccgacggtg agcaggccga gcgcgtcgat acgcgcgatc
     1321 gagccgccgc cgacgccgat ctcgatcatg tcggtgaccg gcaccttgac cggcagcccg
     1381 gatcccggca gcagccggta cttccggtcc acttcgaact cgtgcgtcac cagcggcgcg
     1441 ccgccggaga tcatgcacag cttcgccgtc gtgccgccca tatcgaaggc cagcaggtcg
     1501 ccgacaccgg ccgcggcccc gatcgcggac gcggccagcg caccacccgc cgggccggat
     1561 tcgaggatcc ggatcggatg gcgggcggcg gtgtcgacgg tcgcgatccc gccgttggaa
     1621 agcatgatgt gcggcgacgg ccgcactccg gcctcgtgca aacgccgttc caggtcacgc
     1681 agatagcgct cggtgaggtc ctggacgtag acgttcgcga ccgtggtcga ggcacgctcg
     1741 aactcgcgga tctcgggaac gacctcactc gacagcgcga ccctcaaccg gggcgcgacc
     1801 tctctcagca cctcggcggc gcgtcgttcg tgcacgggat tcgtgaaggc gtgcaggaag
     1861 cagatcgcca ccgcgtcgat cccgcgggcg tcgagctcgc ggcccagccg cgcgacgtac
     1921 tcctcgtcca gtcctgtgtg gacataaccg tcggcgagga tccgctcggg gacgtcgaag
     1981 cgcaggtgac gcgggaccaa cgggtcgggg agttcgatga gcaggtcgta gagttcgtac
     2041 cggtgctcgc gccgcatctc cagtacgtca cggaaaccgg cggtcgcgag cagcgcggtg
     2101 cgggcaccct tgcgttcgat cagcgcgttc gtgaccaggg tggtgccgtg cacgaactgc
     2161 tcgacgtcgc ccgcgtccag cccggcgtcg gcgagtgtcc ttttgagacc ttcctcgacc
     2221 gcgcgggcgg gctcgtcgtg cgtggtcagc accttgccga cggcgacgac cccggtttcg
     2281 tcgagcacgc agagatcggt gaacgtaccg ccgatgtcca cgccgacccg aagcccggtc
     2341 acggggattc cttgcggtac cagcgcggcg aggtgttgag cggcggcgcc attttcgcgc
     2401 ggacgaccag cacgttcggc tcgtcggact cgacgaactc gccgagcagc cgccggaacg
     2461 cccgcccgaa cccggagacg cgatccgcgt gcacgccgaa agacctcgcg aggccgacga
     2521 aatcggggct gtcccaatcg acgccccggc gcggcagccc ggcgcgatct tggtcgtagc
     2581 gaagcatccc gtacccgccg tcgtcgacga cgatcgtcgt gaccggcaac tgttcctgtg
     2641 ccagcgtgtg gaggtcaccg cagccgaaga ggaagccgcc gtccccggtg acacagatcg
     2701 cgcggccgcc gcccgcggcg ccggcaccga gcgccgcggg gaaaccgtag ccgagcgtgc
     2761 cccagcccat cggatacgcg agcttgcgcg gcgcacggac ccgatggaat ccgccgatcc
     2821 agtacccggc cacgcacatg tccgcgacca ccaccgcgtc gggcggcaat acctcgtcca
     2881 aagtggacag aaggtccgcg gcctgcggct cctcttcctt gatccgctgc cggacccggg
     2941 cggagacctt ggcgagcctg ccgacgagcg ccgcgatccc ggaccgctcc tcgaccttca
     3001 gcgcctcgac gagcacccgg gcgtcgccga ccagcgtgat gtccggctgg tagttcttgg
     3061 ccgcgtcgtc cgggtcgacg ttgatcgcga tgagcttctt cggccgcggc atcagccagt
     3121 tctgcgtcat cagcccgtcg aagtcggtgc cgatcgcgag gacgacgtcg gcctcgtccc
     3181 acagcgcgcc gacctcgggc gcgtgcaccg gattcggggc gagacaggga tgatcgaccg
     3241 acaggagccc gcgggcgccg aacgtggtga gcaccggcgc ggccagccgc tcggcgagtt
     3301 tcccgatcgc ctcccccgcc tcggcacgca gcgcgccgcc gcccgcccag atcagcggcc
     3361 ggtccgcggc ggcaagcagg gcctcggcct cggtgagatc cgggatctcg gcaggccggg
     3421 cgtgcgaacg cggcggacgg cgcgcgggcg tgcgctcgga caggaagtcg gtggggatgc
     3481 cgaggtagac cggcccgctc tgcggctgga gcgcgagccg ggccgcgcgg tggagcgtgg
     3541 cggcgacctg gtcggcgctc gtgacggtga acccggcctt cgtgaccggc gcgaacatcg
     3601 cctgctgatc cgacgtctcg tgcaggacgc cgcggaccac gccgtgccgc cgcagcgtgg
     3661 acgggatgtc ggtggcgatg atcagcaccg gtgccgccga cgccatggcc tcaccgaccg
     3721 ccgcgagggt gttcgccgcg cccggccccg tggtcaccag cgcgaccccg agcttgcccg
     3781 tggcgcgggc gtacccgtcg gccgcgtacc cggccgtctg ctcgtgccgg accccgacga
     3841 gccggatgtc cgtatcggcc agcgcctccc ataacggcag gttgtgcacc ccggggagac
     3901 cgaagacgac ttcggtcccc agagcggtca gcgcgtcggc gagatgctgg gctccggtgg
     3961 gtgcaggcac cccgccgata gtgccagatc gttcaacgat ccagcaacca gccacggcgt
     4021 gtgaaggctc cgccagctca ctccggcacg tcgagtgtgg aggattcggg acgttgaatg
     4081 tcccaaatcc tccacactcg aatcacctga cctgcgcgag gatcgcgcta cccggtgtgc
     4141 caggagggtg acggtgtagg aatcaggacg ttgagtgttc ccgattccta catcgtcgga
     4201 ggctgttccg acctccacac tcgccgatat cggccccgct acggcagcag gacgcccctc
     4261 agtacaggcc cgccgcgtat cgtcccggct cgtagtacgc ctcgaggtcg gccatgctct
     4321 cctccggccg ctcaaaggtc ttcgagatcg ccgcccgcga cggcagcgcg ccgggcgtcc
     4381 agctctccgg cgaccacagc ttcgaccgca tgaacgcctt ctggcagtgg tggaagatct
     4441 cgtcgatgtc gacgaccagc gcgagcttcg gccggttgcc cttcacgatc atgtcgtcga
     4501 agaacggcgc ctcgcgcacg agccgcgcgc ggccgttgat ccgcagcgtg tcgccgcggc
     4561 cggggatcag gtagatcagc ccgacgtgcg gattcgacag cacgttgtgg aacccgtcgg
     4621 cgcgccggtt gcccggccgc tccgggatgg cgatccgcgt gtcgtccagc accagcgtga
     4681 acccggccgg gtcgcccttc ggcgatacgt cgcaggtgcc gtcggccgcc gaggtcgcga
     4741 tcagcacgaa cggcgactcc gcgagccatt gccggtccag ctcgtgcagc ttcggtcgcg
     4801 ccttgttcgc ggtccgctcc agcggcggcg gcaggatctc gcgcagttcg gcctcggtgg
     4861 tgacttcgac gaactcagac aatgttgtgc tccctcgtca cggcccggtc gccggcgaac
     4921 cggcggacgt cgagcccggt gatgtcgatg gccgggaccc gccccaggta gaggtcccgc
     4981 acgagctccc ccacggccgg gcccatctgg aacccgtgtc ccgaaaaccc ggtcgcgtag
     5041 aagaacctcg acaggtggac gctttccccc acgatctggt tgcggtcggg ggtcacctcg
     5101 tacagcccgg cccagccgcc gcggatcccg gcgccgagca cggcgggcac ccggcgcgcg
     5161 gcgatctcgg cgagtttcgg cagccactcg cccggctgat accgggtgtc gaagccgggg
     5221 tcgccgtcac cgtcgcagaa ggacatcgcc aggccgaggc cctcgcggtg gaagtagaac
     5281 gccgagggca tctcgatggt cagcggcact cgctcgggca agtccgtgac cggtccggtg
     5341 aacacgacct gccgccggta cggccgcacc gggagctcga caccggccag ctcgccgatc
     5401 cgtcccgacc acgcgcccgc ggcgcagacc accgcgtccg tccgcacgaa accggccgac
     5461 gtccggacac cggtgatctc gtcgccgtcg cgttcgatcc cgacgacctc gacgccggtc
     5521 ttcagcaccg cgccgtgccc gcgggctgcc cgcgcgtagc cctgcaccgc cgagtccgga
     5581 gtcgccttgg cgtcgtcggg cgaccacagc gccgcgacca cgccttcggt gtcgatcagc
     5641 ggggagaacc gccgtgcctc ggcgggctcg acgagacggc tgcggacgcc gtaggagttc
     5701 tgcagttcgg cgcagcgttc gaattcgggc agatccgctg ggtcggtgac caggtacaga
     5761 tagccgtcgc ggcggaagtc gatctcggtc ccgtacgtct cggcgaaaga cgcgtactcg
     5821 gccagcccgc gcagcccgat ctcgatgttg acccgggtgg tgaacgacga ccggatcccg
     5881 cccgccgcct tcgccgtcga ccccgccccc agcgtgtcgc gttcgaggag cagcaccgag
     5941 accccggcgg cggcgagccg gtacgcgcag gcgaccccga tgatgccgcc gccgatcacg
     6001 acgacgtcgg tgcgttcagg cagtgactcc atccgtgtcc ccgatccgtt cgtcctcggg
     6061 cggcggtccc ggcggcgtgc cgtcgccgaa cgggcgcccg cccagctgct cccggtgatg
     6121 cggcgtccag ccggacaggt ccggtcccaa agggacgatc cgcgtcggat tcacctgctc
     6181 gtgcaccgcg tagtagtgcc gcttgatgtg gtcgaagtcg acggtgtcac cgaagcccgg
     6241 cgtttggaag aggtcgcgcg cgtaggccca cagcaccggc atctcggcca gcttgttccg
     6301 gttgcacttg aaatgcccgt ggtagacggc gtcgaagcgg acgagcgtgg tgaacaaccg
     6361 gatgtccgct tcggtgatcg tgtcaccgac gaggtagcgc tgcttttcga gccgttcgga
     6421 aagcacgtcc agcatggtga aaagccgggt gtaggcgtcc tcgtacgcgg cctgcttggt
     6481 cgcgaaaccg gcttggtaca cggcggcgtt gacgtcggcg tagacccccg cgttgacgtc
     6541 gtcgatctcg ccgcgcagtc gctctgggta gaggtctggc gcgccgggcc ggtggaagct
     6601 ggtccattcg gtggacagat cgagggtgat ctggggatag tcgttactca ccagccgttt
     6661 gctcggaatg tccacaatgg ccggaacgct gatcccgccc atatagtgcg ggtcggccgc
     6721 gtgataggcc tcggcgaggt acttgatccc gagcaccggg tcccggtcac cgggatcgag
     6781 ggtgaaccgc cagctcttct cgtcctggat cgggtcggcc acggccacac tcaacgcgga
     6841 ctcgaggccg agcagccgcc ggacgatcag cccgcggctc gcccagggac aggcccggct
     6901 gaccaccagc cggtatctcc ccgcctccac cggccagccg tcgcggccgt cggcggtgac
     6961 acgcgcgtcg aaatggttgg cggaccgacg gaactcaccc gtctgcggat cggtcgggat
     7021 cgtcatgtga gccaccctaa agcgtgagat ggtggtttcg gtgtgcgtag actctggcac
     7081 ccggcgtgtc cgcacgccgc cgcgcggaag gtggtcccga cgatgccgtt catgcccgtg
     7141 accgattcga tgttccttct cgtggagacc cgcgaacatc cgatgcacgt cggcggactg
     7201 caactgttca agaaacccga gggcgccggt cccgactacc ttcgcgacat ccgcaagagc
     7261 atgctcgagt ccgacaacat gcgctcggtg ttccgccgcc gtcccgcccg gccggtcaac
     7321 accgcgggcc acctcgcctg gtcgaccgac accgacctcg aactcgacta ccacttccgc
     7381 cattcggcgc tgcctcagcc cggccgcatc cgcgaactgc tggagctgac cggacgctgg
     7441 cacagcacct tgctcgaccg gcaccgcccc ctgtgggaga tccacctggt cgagggcctg
     7501 caggacggcc ggttcgcgat ctacagcaag atccaccacg cgctgatgga cggcgtctcg
     7561 gcgctgcggc atctgcaggg cacgctgtcg gacgacccgg ccgacctcga ctgcccgccg
     7621 ccgtggggac gccgcgccaa accggacggc ggccgcaacg gcaaggcgtc gccctcggtg
     7681 ctcagcgctt tcggcaagac ggtcaaccag ctcgccggga tcgcgcccgc cgcgatgaag
     7741 gtggcgcggg aggcgttcca ggagcacacg ctcacgctgc cggcgcaggc gccgaagacg
     7801 atgctgaacg tgccgatcgg cggggcccgc cggttcgccg cgcagtcgtg gtcgctggac
     7861 cgggtgcgca aggtggcgac cgcggccggg gtgtcgcgca acgacgtcgt cctggcgatg
     7921 tgctcgggcg cgctgcgcga ctacctgatc gaacagaacg cgctccccga cgcgccgctc
     7981 accgcgatgg tcccggtttc cttgcggcgc aaggacagcg gagacgcggc gggcaacaac
     8041 atcggcgcgc tgctgtgcaa cctcgccacc catctgaccg atccggccgc gcggctcgcg
     8101 accatcaacg cctccatgcg aaacggcaag aagctcttct cggagctgac cccgctgcag
     8161 acgctgctgc tgtccgggat caacgtcgcg cagctcggca tctcaccgat ccccggtttc
     8221 gtgaacaaca cgaaaccgcc gttcaacctg gtgatctcca atgtgccggg gccgcgcaag
     8281 cagatgtact ggaacggcgc cgcgctcgac ggcatctacc cggcgtcggt gctgctcgac
     8341 gggcaggcgc tgaacatcac gctgaccagc aacggcgaca acctcgactt cggcgtcacc
     8401 ggctgccgcc ggagcgtccc gcatctgcag cgcatcctga cccacctgga caccgcgctc
     8461 gtcgaactgg aacacgcggt ctccctgccc cgcgtttagt cctctggatg cggtagccca
     8521 ccgcatccag aggactaaac gcgccggggg ggctagctgc cgtcggagac gtacaggccg
     8581 cccggggtga tcgtgtacag ctggccgtcc gggccggcgg tcgcgtcacg cgtgcggccg
     8641 aggttggtcc agagcttgcc gccgttgccg ttcaggtcga gcttgtacgt gccgcccttg
     8701 agcgacgcca tgtacagcga acccttgtac gcggcgagcc cgctcggcgt cgccgaggac
     8761 gtcggccacg acttgaccgg gttcgtcatc cccgccgtgt tgcacgggcc ttcgcaggtc
     8821 ggccagccgt agttcttgcc cggctcgatc ttgttcagct cgtcgagctt gttcgcgccg
     8881 atgtcggaga tgtacagctg cccgttcgcc caggtcagcc cctggacgtt gcggtggccg
     8941 taggagtaga cgcggctgtt gaacgggttg ccgggcgcgg ccgcgccgtc ggtggtgacg
     9001 cgcaggacct tgccgccgag ggagttcttg ttctgcgcgt tggcaccgtt ctggccgtca
     9061 ccggttcccg cgtagaggta gccgtccggc ccgaagcgga tccgcccgcc gtggtggtac
     9121 tgcgagccac gcgggatgcc ggtgacgatc ggcgtcggcg gctggcccag cttcagcttg
     9181 gcgatgcgat tgtcggaact ggtcgtgtag tagatgaaga ccgtctcgtc ggtggcgtac
     9241 ttcggagaga cggcgatgcc gagcaggcct gcctccgcgg tgacgctcac gccggggatg
     9301 gtctggaccg tggtgacctt gcccgccttg tcgatcttgc tgatcgtctt ggcgtccttc
     9361 tgcgtgaaga cgccggtgcc gtcgggcagg aagtcgatcg accaggcctg gttgaggccg
     9421 ctcgcgagct gcctgatcgc ctgggccgac ggcggcgttt cggcggccgc cgggacggcc
     9481 gcgatcgaca cggccgtcgc cgcggcgaac gtggcggcga gaatacgacg taaggacatg
     9541 ggacgcctcc ttcagctaca cccctggagc cccgcgaagt tggatagaaa cacacaacat
     9601 aacgaaacgg acaccactgg acgggctatc ggcggcgcgg gctgttaacc gttgtgtgcg
     9661 ccgagcgtga cgaatcgggc ggcccgatcg gccataggta ggaaacttta caaaatgcca
     9721 gcggaagtcg ccccttacgt ctggtcagaa tcggggacac gcttctaggg tggcggggct
     9781 cggccccgtt cgatcccatg tggacgttag gagcaggaaa tgaccgaaac catcgaggta
     9841 tggaccacgc ccgacttcgt cgagtacgaa acccccatgg aggtcaccgc ttacgcggcc
     9901 cgcatggagg actgaaaccg catccggtgg tgggggccgt cccccaccac cgcgccgtcg
     9961 tcccgatcag cgagccgttg gaggcagcac ggtgtccgtc atgtcgtcgt cggagttcat
    10021 cgcggctctg cgcgggcttt cgcaccgcta ctggggcacc cacccgttcc atgtgcggat
    10081 gcacaacggc gagctgtccg agtacgagct gaagatctgg gccgcgaacc gctggtacta
    10141 ccaatgtgtg ctcccgcaga aggacgcggc catcatcagc aactgcccgc tgccggagat
    10201 ccgccgtgaa tggctcgacc gcatcgtcta ccacgacggc gcgaaggccg gggacggcgg
    10261 aatcgagcga tggctccggt tgtgcaccgc ggtcgggctg gatcgcgaag aggttctcga
    10321 tcagcggcac gtcgcccccg gcgtgcggtt cgccgtcgac gcctacgtga ctttcgcccg
    10381 cacgaagcct tggctcgaag cggtcgcttc ggggctgacc gaaatgttcg ccggccatct
    10441 catgcagcgg cgggtcgccg acatgctggc gaactattcg tggatcgccc cggaagacct
    10501 cgcctacttc accaaccgga tcgacaaggt ctccggcgag ggcaagggaa cgctcgacat
    10561 cgtggtgcgg cacgccgtca cccgtgagca gcaggagaag gcgatcgccg cgctgtcgtt
    10621 caagaccgac gtgctgtggt ccatgctcga cgccatcgag cgcgcggcgg ccaaggagta
    10681 gccatgacca ccctcgacct gggctcggtg ccgcggctgc ggcgcggagt ccggctgagc
    10741 tacgaccaga ccagggaaac gcacgtcctc ctgttccccg aaggcgtgct cgtccccaat
    10801 cccacggcgg cggccgtgct ttccctctgc gacggcgtgg gggacgtcgc ggcgatcgct
    10861 tcggcgttgc gcgagcgcta cgccggtgtt cgcgaggaag aaatcctgga cgtcctgtcc
    10921 cggctcggag atcggcggat cgtcgaatgg acctgaacac cgcggcaccg ctgggcatgc
    10981 tggccgagct gacccatcgc tgcccgctgc attgcccgta ttgctcgaat ccggtggagc
    11041 tgatcgcccg tgacggtgaa ctgtccacag aggaatggat ttccgtgctc tcgcaggcgc
    11101 gggaactcgg cgtgctccag gtacacatgt ccggcggcga gccgctcgcc agaccggatc
    11161 ttcccatcct ggtcgagcac gccacgaaac tcgggtgtta cgtcaacctg gtgacgtccg
    11221 ggctcgggct gacagagtcc agattggacg acctcgtcga acgtggcctc gcgcatgtcc
    11281 agctctccgt ccagggcgcg accgccgacc gcgcggaccg gctcgccggt gcgcgcgccc
    11341 atgaccggaa gctggtcacc gccgaactga tcacgaaggc cgggctgccg ctttcggtca
    11401 acgtcgtcct gcaccggcag aaccacgacc agctcgccgg aatcatcgac ctggccgaga
    11461 aaatgggcgc ggaccggctc gaactggcca atacgcagta ctacggctgg gccctgcgca
    11521 accgcgacgc cctgatgccg acccggcggc aactcgagga ggccgagccg atcgtgcgcg
    11581 cggccaccga ccggctgcgc ggccgcatgg agatcatcta cgtcgtcgcc gactattacg
    11641 agcagtaccc gaagccgtgc atgtacggct ggggcgcgcg gcaactgacg gtggcacccg
    11701 acgggaacgt gctgccgtgc cccgcgtcga cggcgatcga gaccctggaa ttcgacaacg
    11761 tgcgggacaa gccgctggcc tggatctggt acgagtccgc ttccttcacc gcttatcgcg
    11821 gcgaggactg gatgtcggac acctgcggca cctgcgagcg gcgcgcgatc gacttcggcg
    11881 gctgccggtg ccaggcgttc cagctcaccg gtgaccccac ggcgacggac ccggtgtgct
    11941 cgcgttcacc gcatcgcggc gtggtcgacc tcattctcgc cacgccgacg aaaacggacg
    12001 aactcgtgat gcgggcaccg cgatgagggt gatcctgctc ggtaccgcgg cgggcggcgg
    12061 tttcccgcag tggaactgcg cctgcgcgct ctgcgtgtcg gacgcgccgc cgcggaccca
    12121 ggactgtgtc gcggtgagcg cggacggcga gggctggtac ctgctcaatg tgtccccgga
    12181 catccgtgca cagatcctcg ctacgccgcc cttgcgcgcc gggccggggc cgcgggagat
    12241 cccgctgcgc ggggtgttgc tgaccgacgc cgaactcgac cattcgctcg gcctgcttct
    12301 gttgcgggag gcgggcggac ttcccgtgtg ggcgcctgac gccgttctgg gcgccttgtc
    12361 cgaacagttt cccgcgaggg cgatcatcga cggctatggc ggctgggagt ggctgccgtc
    12421 gtcggatgtc tccatcgacg gtctccgcgt gagcatgctt cccgtgagcg acaagcggcc
    12481 gaagtacgcc cgttcgtcca ctgaggacgg accgtgggtg gtggcgtacc ggatcgaaga
    12541 cgtccagacc ggcggcgtct tcgtgtacgc accttgtctg aagagctggc cggacggatt
    12601 cgacgacttc acgcgcgacg cgggcctggt gctgctggac ggaaccttct acgcgccgga
    12661 tgagatgtcg ggcgccaccg cggccgaggt cggcgacggc gcccagctgg cgatggggca
    12721 tctgccgatc accggcagcc tcgcgaagct ccggccgggc ccacggtggg tgtacacgca
    12781 tctgaacaac acgaacccgg tgatcgaccc ggcctcgccg gaacacgccg ccgtgctggc
    12841 cggcggcgcc tcgcttccgt tggacggtac ggaattcaag ctctaggcaa cgccttcggg
    12901 gctcgctccc gaaacaggaa cggcgtcggc ggtgagacga tcgatctccg cgagctcgtc
    12961 cgcggacagg tcgatgtcgg cggcggccaa gctggcctcg acgttggccg ccttgcgcgc
    13021 gcccacgatc gcgacgtgta ccccgggctg ggcgagcgtc cacgcgatcg cgagctggct
    13081 gaccgagatc cccttgcccg cggcgaattc cttgagcctg tcgaccacgg cgaggttgcg
    13141 caggaaggtg tctccggtga acgccgacga ccgggaccgc cagtcggtct tctcgaacgt
    13201 cgtctcgggt gtgaaggctc cggtcagcaa accgctgccg agcgggctgt acacgagcac
    13261 gccgatgtcg ttctcgcgtg cgtacggcag aggatcggtc tcgatgtccc ggcggaacag
    13321 gtgatacggc ggctgcaggg tttccaccgg acgggtctcg tcgaaggcgg ccagcccggc
    13381 ggcgtcgtag ttcgagacgc cgacgtgccg gatcttcccg gcgtcgacga actcctgcag
    13441 gatccccgcc gtttcctcgg ccggggcgtc ggtgtcgggc cagtggatct ggtagaggtc
    13501 gatgtggtcg acgtcgagaa aacgaaggct gtcctcgacg ccctgcgtca gccactcgcg
    13561 ccgggagtcg cgtggccgtt cggagcgcgg cttgatgccg cccttggtgg cgatgacgag
    13621 attgtcccgg tcgcgcttga gctcctcgcg cagcgccttt cccagcatgg cttcggactt
    13681 cccgaaaccg taggcctggg cggtgtcgaa gaggttgacc ccgagttcgc gggcgtgatg
    13741 gatcgcggcg atcgccgtgt cctcgtcgaa cgaaccccag tccccgccga gctgccaggt
    13801 gccgaaggcg atcctcgaca cctcgaggcc gctcctgccc aatgtcgtcg tacgcatgac
    13861 tccagcagag cacagacatc ggatcaccgc accggttctc ccggccaatg aaacccccaa
    13921 ataactgttt gacggttgcc gtcccggcag tcgatactcg tgacatgtcc gagtccccca
    13981 gcctcgatgg gcttcgcgtc ctcgcccatc ctttgcggtt gcgcattctg tcgcttttga
    14041 ccggtgtcgc gatgagcgcg gccgaagccg cgcgcgaact cggtgagaca caagcgaatg
    14101 tcagctatca cgtgcgacgg ctgcacgagg ccgggctgct cgacgtcgcc gaggaggtcc
    14161 ggatccgggg cgggctggcg aaacgctacc gccacgatcc ggagtccggg atgcggttca
    14221 cctcgaagca tccggacgag gagcagcttc tcatcgcggc gatggtcgaa gaactcaagc
    14281 gccgcagcga attccgcttg ccggacgaac gcgggtcgat cagcgacgcg gagatgtggg
    14341 tcgaccgcga gacctgggag aaggcgctcg aacacgctcg cgaactgagc gatctgctgc
    14401 actcggccgc gaaaccaccc cgcacccgcg gcacgatccc ggtcagcgcg acggtggcga
    14461 tgttcgagat gaggcgaccg tgaccaccct gcgcgaacca ctgcgccacc acaacttccg
    14521 ctggctgatc gccggccgca cgttcgggga gttcggcaac gccgtcgccc cgctcgcgct
    14581 cgcgttcgcc gtgatcgacc tgaccggttc cgccgtcgac atcggcatcg tcgtcggcgc
    14641 ccgctcggtg gcgagcgtgg tgctgttgct gttcggcggg gtgctcgcgg accggctgcc
    14701 gcgctcggtg atcctgcaag gtaccgaagt cgccgccacc ctgacccagg ccgtcatcgc
    14761 cgcgagtgtc ctttgtggat tcgcctcgat cccgctattg gtcgccctga gcgtggtcaa
    14821 cggcgcggtg gccgcgatct cggccccggc gtcggcgtca ctcaccccgc tgacggtgcc
    14881 cgccacccag ctcgcgcagg cgaacgcgct ggccaggctg ctgtcgaact ccggccggat
    14941 cgccggtgcc ggactcggcg gcatcctcgt caccgcggtc ggccccggct gggcgctcgc
    15001 cgggaacgcg ctcctgttcc tgggttcggc cctgtcgtac cggtgcatcc gcctcaaccg
    15061 ccgggaacgc gtccccggca gccgtccact ggcggagctc gccgaaggct ggcgcgaatt
    15121 ccggtcacgg acctgggtgt gggtcgtggt cgtgcagttc atggtggtga acgccgtcat
    15181 cgccggcggg atcgcggtgc tcggtcccgt cgtcgccgac agcaccttcg gacgctccgg
    15241 ctggggtttc gccctcgccg cgcagacgat cggctcgctc gtcggcggga tcctcgtggc
    15301 ccgatggcag ccgcggcgcg cgctgttcgt cggtgtcgcg gtgatcctcc tcgaagcacc
    15361 gccgctgatc cttctcggcc aggcgccctt gctcccgctg ctgctcgcgg ccatgttcgt
    15421 ctccggcctg gcgatcgagc agttcgtggt cgcgtgggac gtctcgctgc aggagaacgt
    15481 gcccgaggac aaactcgcgc gcgtctactc ctacgacatg ctcggttcct tcatcgccct
    15541 gccgctcggc cagatggcgg ccggacccgc cgcgcaccac ttcggagtca gcacgaccct
    15601 gctcgcgtgc gccgccctgg tcgtggccgc cacctgtctc gccctgtgca gcggtcaggt
    15661 gcgcggactg gtccggaaga cccacgccgc ccagccctga ccacccgccc gcgaaagtgg
    15721 tagcaaaggt ccattgctcc ctttccgcag gtcacggcca ggggcggacc tcctcgagga
    15781 gcttcgcgac cgcgagcacc aggtcgtcgg agtgccgcgg gccgacgatc tgcagaccga
    15841 ccgggaggcc actggaggtg cggcccgccg gcacgctgat cgcgggctgc tgggtcatgt
    15901 tgaacgggta ggtgaacggc gtccagtccg gccagccgct cagcccactg cccggcggca
    15961 cctcgtgccc ggcttcgaag gcggggatcg gcagggtcgg cgtgatcagc acgtcgtagc
    16021 gcgtgtggaa ctcgcccatc aggatgccca gcgcggcccg ctcggcgttg gcgccgaggt
    16081 agtcgctcgc cgagaaggtc ttgccgagct cccagacctt ccgcagcccg gggtcgacct
    16141 tggtctccga accggcgggg aaggtgtcca gccacttggc cgcccccgtc gaccacagga
    16201 tgtcgaaggc gggcttggga tccgcgaaac cgggatcggc ctcttcgatg tgcaggcccg
    16261 cgtccccgag cgactggacc gccgacttga cgatctccgc gacctccggg tcgacgtcga
    16321 catagccgag cgtcggcgag tacgccgcga tcagcccgcg cacgtcccgg cggacagcct
    16381 cgcggtaggt cgagaccggc ggggcgagcg cggccgggtc gcgatagtcg ggcatcgcga
    16441 gcacgtcgag gagcagcgcc gtgtcgtcca ccgaacgcgc catcgggccg gcgtgcgaaa
    16501 gcggcccgaa cgggctcgcc gggaacagcg ggatccggcc gtgtgtcggt ttgagaccga
    16561 cgattccgca gaacgaagcc gggatcctga tcgagccgcc accgtcggtg ccgacggaaa
    16621 gctcgcccat ccccgccgcg acggccgcgg cgctgcctcc actggagccg cccgccgtag
    16681 tcgacgggtc gaccgggttg cgggtgatcc cggtcagcgt gttgtcggtg acgcccttcc
    16741 acgccagttc cggcgtcgtg gtctttccca gcagtaccaa gccgttctca cgcagtcgtg
    16801 cggtgaccgg gctgtcgacg tcccacggct ggtcggggtc gatgcaccgc gaaccgcgca
    16861 gcgtcggcca gccctgcgtc aggaacatgt ccttgatcga ggccgggaca ccatcgagcc
    16921 agccgatcgg attaccgtcc cgccaccgga cctcggacgc tttcgcctgc tcgagcgcgc
    16981 catcggcgtc gaccaggcag aaggcgttgg tctcaccgtc gcgctcctcg atggcacgca
    17041 acgcggtctg ggtggcctcg accggtgaca gctctccggt ggcatacgcg gcgacgagct
    17101 cactcgcggt caacttggtg tcgttcaatc cggcccctaa ccttggcgaa gcgtctccga
    17161 cggcacgtat ccgagctgct tgtccacgac gttgcgcagt gcctctcccg cgcgccagcg
    17221 acggaagttg tccgcgaaca cctctaccag agtattacgc cagccgacga agtcgcccga
    17281 catatgcggc gagatcagca cgttctccat agtccacaaa ggactttcgg cgggcagtgg
    17341 ctcggtgtcg aagacgtcga gtgccgcacc gccgagcggc ccgtcccgca gcgcgccgat
    17401 caggtccgac gtgacgacca gttcgccgcg tccgacgttg acgaaccgcg agccgggttt
    17461 catcacgccg aaggcttcgg cgtcgaacat gcccttggtc tgctcggtca gcggcgcgac
    17521 cgcgacgacg tagtccgctc cgggaagatg ccgagacagc tccgacgacg catacacgtc
    17581 accgaagtcg ggatcgcccg cacgaggacg gcgtccgaca cccgccaccg acatcccggc
    17641 cgcccgcaac atccgcgcga tcgaccggcc gatcggcccg gtgccgacca ccagcacccg
    17701 gcggccggag atccgttcac tctcccggtg cttccactgc cgctgcttct gcaggtccca
    17761 cgaccgggcg aaatccttgg cgaacgtgag gacgaccccg agcacgtact cggctatcgc
    17821 cccgtcgaac accccacgcg agttggtgag cacgacgtcg ctctcctgca gcccggggaa
    17881 gagcaccggg tcgacgcccg cgctggcgat gtgcagccag cgcagacggt cggccgcatg
    17941 ccaggcaccc gggacggcgg tggagaggaa gtcgtagacg aagaacgcgt cggcgccgga
    18001 taacgcgtcg gccaacccgg ccgcgtcggt gtaacgaacc accgcttcgg cttcgatagc
    18061 gcgcatgtcc ggtgggcgcg tgtctccgca gagcaccgcc agcacagggg tctccgaggc
    18121 gatcacgttg acaccgtaaa agtggctcgt atgattgtca acaatccgag gaacgacccc
    18181 cggagcaccg gacctgtgac agcagaagct ttccggaggc tgagacttgg atttcgactt
    18241 actggagttc gaaggcccgt tggcgcagcg cggtatcggc gtgatcgccc ccttcgacct
    18301 cgctctggaa cgcgagctat ggcgctgggt acccatggag gtctccctcc atctggcgcg
    18361 cacgccgtac gagccggtgc ccgtcagcat ggagatggcc cagctcgtca gcgacagcag
    18421 gcatctcgcc gccgccacga gggacgtgct ccacgtggag cccgaagtcg tcgcctatct
    18481 gtgcacctcc ggcagtttcg tcaacggtgt ggactacgaa cgttctctga ccaaggcgat
    18541 ctgcgacgcg ggcgcgacgg acgccgtcac cacgtccgga gcgctggcgg aggtcctgca
    18601 tcagctcgac ctccaccggg tctcggtgct gacgccctac gacggcgacc tgaccgggaa
    18661 gctgcacgac ttcctggccg aactcggcgt ccgcaccgtt tcgagcgacc acctcggcct
    18721 gggcggcggc atctggaagg tcagctaccg gaccatcgcc gaacgcatcc tcgccgccga
    18781 ccacgccgac gcggaagcca tcttcgtcag ttgcaccaac ctccccacct acgatctgat
    18841 cgagccgctc gaaagcgcgc tcggcaaacc cgtcctcact gccaaccagc tcacgatgtg
    18901 ggcctgcctc cggcggatga acctgccgat cgtcgggccc ggcaagtggc tccgggaggt
    18961 cgactgacct cttcccttac gattgtcgac aatctgccct ccggaggttc cgtgcccatc
    19021 acgccgttcg ccccacccga gccgccgtcc gagacgacca ccatcgggtt catctacccc
    19081 gatcacgcgg ccgaagacga ctacccgctc gcggaacagc tcctcggcgg ggacatggcc
    19141 gggatcaaac tgccggtcga gcacatctac ggaaccgatc tccacgccgt gcccgagcta
    19201 ctggacctcg gcagcgaaag ccggctcgcc gacggcgccg cgctgctcgc caagcacgaa
    19261 ccggacgcgg tggtctgggc gtgcacgagc ggcagtttcg tctacggctg ggaaggcgcc
    19321 cgagaccagg ccgaccggct ggccgccgtc gccggtgtcc cggcgtcgag cacgtccttc
    19381 gccttcgtca acgccgcacg ggcgctcggc gtccggcggg tcgcggtcgc cgccagctac
    19441 ccggacgacg tcgcccggct gttcgtcgag ttcctcggcg cgggcgggat cgaagtggtc
    19501 tcgatgggca gcgcggatat cgacaccgcc gccgaagtcg gcgatctcag cccggaggcc
    19561 gtcgtcgaac tcgcggtgag ccgcgaccat ccggccgccg acgccctgct cgtccccgac
    19621 accgccatgc ggacgctcgg cgagatcaac acactcgaaa cccggatccg caagccggtg
    19681 ctgaccgcca accaggtcac cgtgtgggag ggcctgcggc tcaccgggaa gtccccgctc
    19741 gtccgcacct tgggcgcctt gttcggacag aggagaagct gagccatgtc cttgccggat
    19801 atcgagccgg tcagccggga atcgaccgcc gggatcatcg cgcgccagtt gcgggacgcg
    19861 atcatgaccg gcgccctccc acccggcacc cagctcggtg aaacggatct ggcctcccgg
    19921 ttccaggttt cgcggggacc gctgcgcgag gcgatgcagc atctcgtgtc cgaagggctc
    19981 ctgcgcagcg agcggcaccg cggactgttc gtgatcgacc tcgaacccgg cgacgtctac
    20041 gacatctact cggcacgctc ggccatcgaa cgagccgcga tgctgcgcgc cttgcgcggg
    20101 gaccgggaac gggtcgccac cgaactcgag gaggccgtgc gcgccatggc cgccgccgcg
    20161 gacgaggacg acccgaccgc gctctcctgg gcggacctcc gtttccacga ggcgctaatc
    20221 gccgcctccg gcagcaaacg gctcgtgcgc atggcgcgga ccctgttgat cgagaccagg
    20281 atgtgcctca ccgcgctgca ggggacctat cagcaggtcg aagaacgggt caccgagcac
    20341 accagcatca tcgaggccct gcgggcgggc gacgaagaga ccgcgctttc gctgctggag
    20401 gcccatatgg aggacgccgt ccaacggctg gccccgggaa ccagcctgcg ggagggcgaa
    20461 gctcccgctg tgccttaaag agtcagccac ggccccgcgc ccccagcacc ggttgcccac
    20521 cggtcccgcc acggaactcc ctgtcccacg gccaattgcc gtgctcgtcc tcgtagacca
    20581 gttgcagggc ccggaagttc tcgccgtaca gcagaacagc ggtgagcagg tgcgccgacg
    20641 gagaactgag cgggacgacc tccaacgacg gccaacccac ctccgcgggc agtacctctc
    20701 ccggctccgg cggccccgac cggaccacct gctgggcgaa ataattcagc agctggccgg
    20761 atcttcgttc tctcaggccg gtgacgacga gctccggaag cccggcgtcg gtgagcccga
    20821 ccgtgtacgc gaagcccggt tggacgattc cgcgctcgac cgtctgcacc atccagccgt
    20881 acttgcggat caggggacgg acctcctcga cgaggtagtc gtcgcgggtc tttccggggt
    20941 tgtcgcaatg ccagcacatc ggcactcctc cagtcgtcga atccgatgat cgacactgtg
    21001 caccgcggca ccgacaaaaa cccacacccc ggatcggcgc acgggcggcg aacgggcttt
    21061 catactggac ttcgcgccga gattcccttt agtggcaacg tttttcgtct tgagaaaata
    21121 tgctgattgc cgagaaggaa gaacctgcgg agttcaacgg ccggggccgc ggcgggggtc
    21181 ggcactatcg aggggtacgg cgaacgtgat gtgttgcgaa agccactttc gcaacactga
    21241 aggttgggaa agtggctttc gcaaccttca gcggcctgtc gtgcactaca tgccctgcga
    21301 agtgaatcca acccgctcga catctagacc gtgaaggccc cttccttgcg ttaaacgcag
    21361 cgaaggggcc ttaacgtact aaccgaaatc gtgaatggac cattcatgac atccgggact
    21421 tgacacgcca ccaggaggat ggttcaagat agagcggcga ccaccgcgga cccgagttcg
    21481 gcggtggtgg acttcccgcc gaggtctggg gtctgcacgg tcccctcctc gagaaccttt
    21541 tccacggccg cgcgtacatc ttgtgccgca acggtttccc cgagatgttc gagcagcatc
    21601 gcccccgcca ggatctgcgc caccggattc gcgatgccct gtccggcgat gtcgggagcg
    21661 ctgccgtgca ccgcctcgaa catggaagga agctcaccgg tcggattgat attgcccgaa
    21721 ggcgccatcc cgagcccacc cgtcacggcc gccgccaggt cgctcaggat gtcgccgaac
    21781 agattggaag cgaccacgac gtcgagccgg tccggcgcct gcaccatccg cgcggcgagc
    21841 gcgtcgacat ggcattgttc ggcgtgcacg tccggatact ccgaagagac ctcggcgaag
    21901 atctcgtccc agaacggcat cgagtgaatg agcccgttgg atttggtcgc cgagcagacc
    21961 cgccccgtcc gcgtcttcgc caactcgaag gcatagcgga tgatccgctc caccccgacc
    22021 cgcgtg
//
