LOCUS       NC_021252              21275 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6114118
            Orig. end                         :: 6135393
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21275
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="24"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21275
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21275
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11275](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11275
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     gene            complement(172..1593)
                     /locus_tag="AORI_RS68190"
                     /old_locus_tag="AORI_5440"
     CDS             complement(172..1593)
                     /NRPS_PKS="Domain: PKS_AT (10-302). E-value: 1.1e-58.
                     Score: 190.9. Matches aSDomain:
                     nrpspksdomains_AORI_RS68190_PKS_AT.1"
                     /NRPS_PKS="Domain: PP-binding (396-463). E-value: 1.1e-08.
                     Score: 27.2. Matches aSDomain:
                     nrpspksdomains_AORI_RS68190_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027981.1"
                     /locus_tag="AORI_RS68190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5440"
                     /product="acyltransferase domain-containing protein"
                     /protein_id="WP_043848253.1"
                     /sec_met_domain="PKS_AT (E-value: 1.5e-56, bitscore: 190.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-06, bitscore:
                     27.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHDSLTSTFLFPGQGAYLAGVFSACREAFPVIADELSQVDEYSL
                     RAGGPAVASLLTDPASPTLDRLLENDVPALSLAIFASQIVAARLCREEFGLSPALLVGH
                     SFGEFAALVVSGALTLEEGVTLVVARDRALRASGASGGMVAVEAGFRRVEHLVAAVADR
                     SLSIAADNAYDQVVVSGTTTAVAHLAAVAGALGVKATVLRVPYPFHNHQLLGRANELFA
                     RTVTTITPRVPRIAVHSPVLGRRVETPGDVLEVLSSHLVRPVRFLDALHTIRGEGETRF
                     AECGARSTLVDLATTTLAGISTSAPFRRRADDTGVLAEVRALDAGAETARPMPDPQPAA
                     PAPVPAAQVPTPAPVAVTPAPAEPVVEPVPAQRATSASGEPAGEEGGLVETKVLGELKT
                     LYADAVGYPADVFEDNVELEADLGIDSIRQTELLQRARKRYDVPEADHIRITDYTTLES
                     IAGLIVELSHQGARV"
     aSDomain        complement(205..405)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS68190_PP-binding.1"
                     /evalue="1.10E-08"
                     /label="AORI_RS68190_PP-binding.1"
                     /locus_tag="AORI_RS68190"
                     /protein_end="463"
                     /protein_start="396"
                     /score="27.2"
                     /tool="antismash"
                     /translation="LKTLYADAVGYPADVFEDNVELEADLGIDSIRQTELLQRARKRYD
                     VPEADHIRITDYTTLESIAGLI"
     aSModule        complement(205..1563)
                     /complete
                     /domains="nrpspksdomains_AORI_RS68190_PKS_AT.1"
                     /domains="nrpspksdomains_AORI_RS68190_PP-binding.1"
                     /locus_tags="AORI_RS68190"
                     /monomer_pairings="mal -> mal"
                     /starter_module
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(688..1563)
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS68190_PKS_AT.1"
                     /evalue="1.10E-58"
                     /label="AORI_RS68190_PKS_AT.1"
                     /locus_tag="AORI_RS68190"
                     /protein_end="302"
                     /protein_start="10"
                     /score="190.9"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFPGQGAYLAGVFSACREAFPVIADELSQVDEYSLRAGGPAVASL
                     LTDPASPTLDRLLENDVPALSLAIFASQIVAARLCREEFGLSPALLVGHSFGEFAALVV
                     SGALTLEEGVTLVVARDRALRASGASGGMVAVEAGFRRVEHLVAAVADRSLSIAADNAY
                     DQVVVSGTTTAVAHLAAVAGALGVKATVLRVPYPFHNHQLLGRANELFARTVTTITPRV
                     PRIAVHSPVLGRRVETPGDVLEVLSSHLVRPVRFLDALHTIRGEGETRFAECGARSTLV
                     DLATTTLAGIS"
     CDS_motif       complement(997..1161)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS68190_0002"
                     /evalue="4.40E+00"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="AORI_RS68190"
                     /protein_end="199"
                     /protein_start="144"
                     /score="0.6"
                     /tool="antismash"
                     /translation="AVEAGFRRVEHLVAAVADRSLSIAADNAYDQVVVSGTTTAVAHLA
                     AVAGALGVKA"
     CDS_motif       complement(1204..1311)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS68190_0001"
                     /evalue="2.60E-15"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="AORI_RS68190"
                     /protein_end="130"
                     /protein_start="94"
                     /score="48.4"
                     /tool="antismash"
                     /translation="GLSPALLVGHSFGEFAALVVSGALTLEEGVTLVVAR"
     misc_feature    complement(1483..1485)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1681..1697)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.66"
                     /tool="antismash"
     misc_feature    1736..1749
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.35"
                     /tool="antismash"
     misc_feature    1848..1863
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.98"
                     /tool="antismash"
     misc_feature    complement(1851..1866)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.98"
                     /tool="antismash"
     misc_feature    complement(2068..2083)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.88"
                     /tool="antismash"
     misc_feature    2069..2082
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 22.23"
                     /tool="antismash"
     misc_feature    2198..2212
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.52"
                     /tool="antismash"
     gene            2278..3423
                     /locus_tag="AORI_RS68195"
                     /old_locus_tag="AORI_5441"
     CDS             2278..3423
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="AORI_RS68195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5441"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_016335764.1"
                     /transl_table=11
                     /translation="MTTALALLMQGNDRLATAAQAEMVLADEVCLRHAGCLWHGVTILL
                     RTGEFESVDAHLWKLESRRDDGLADLVALMRAEHAQYVGDLMGAREALERLATTASPPT
                     VRELAVPCYLEVLVAANEPDIGDQVLRDHDFGRLMRRQALRPFLLAVRGYLHLAAGRAD
                     EALKDALECSRLPVTEVAAHFTVAHRRGLLALAAAAAGRPDIAGPAAAREYEAATAWRS
                     HSHIAWALYVLEMVEGEGRPSDRLRDAIDLMELGRSPVGLAALCFEQGRRFLEAGQEQA
                     GRALLLRADGAARRIGDKALSGKIENLLCALTSPAPQASLTAQELKIAELAQNGYTNKQ
                     IAERLVLTVRTIEFHLSNVYRKLGISGRRALANEVLPPPQS"
     gene            complement(3453..5684)
                     /locus_tag="AORI_RS68200"
                     /old_locus_tag="AORI_5442"
     CDS             complement(3453..5684)
                     /NRPS_PKS="Domain: AMP-binding (23-399). E-value: 3.6e-78.
                     Score: 254.9. Matches aSDomain:
                     nrpspksdomains_AORI_RS68200_AMP-binding.1"
                     /NRPS_PKS="Domain: PKS_KR (489-646). E-value: 5e-12. Score:
                     38.0. Matches aSDomain:
                     nrpspksdomains_AORI_RS68200_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027979.1"
                     /locus_tag="AORI_RS68200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5442"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_016335765.1"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-81, bitscore:
                     270.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 4e-35, bitscore:
                     120.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPAQSAVAWDVPAEVNVHDYVLRSATARGDHLAVADLSRGDRRE
                     WTYTQLRAAVAGLATWLRLNGITDDDVVAVLTENSAEFVVAYHGILAAGGVVLALEPRD
                     TGEHWRGKIDAGGAKALIAETALRPPEVEMPVVCVGAVTPGGAAWEEAVTIEPRLTHPP
                     GGDRTAVLMSSSGTEGVPKLVPVTHRNLTSNLGQIDYLHRVRGDDVVLSVPPLRHIYGM
                     QMAMNPALRAGATLVIGATPFSAEDFLRDVTENEVSLSYLVPSVITELGKAGRRLPSLR
                     MIVSGGAPLPTTDGARCAETLGVPVVQGFGMTEAGCVSFSPDGVEVPPGSVGRLVPGTE
                     VKFLGGEDGTEAGELCLRGPQIASAAADADGWLRTGDLVARDADGFLRITGRAKSLIKY
                     KGHQVSPAELEEVLTSHPAVSEAHVTGLPDPVAGEIPKAFVVLSEGIALAEITAYVAER
                     VPPYKRVRAIERVGAIPRSSTGKRTRPPALRVLVTGGGSGLGRAFALALGASGANVLVA
                     GRDEDALAKTVLDIRQTGGTATPVTFDVTDQASVTRGVARATEEYGGLDVLVNNAGIAG
                     PKGPLWAVDEGEWRRTVEVNLFGSTNVIRAVLPALTGRVVNVVSRAGRVGWPNAGAYAA
                     SKAALISLTASLAGEFGETGRVAVAFDPGLVDIGITKAHLDRGRTGVSWEDEILAWTLK
                     TREAGRFTSVEDAAGALVAVVTGAADHLNGRYVSVEDVAPLPSSRLVRQ"
     aSDomain        complement(3747..4217)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS68200_PKS_KR.1"
                     /evalue="5.00E-12"
                     /label="AORI_RS68200_PKS_KR.1"
                     /locus_tag="AORI_RS68200"
                     /protein_end="646"
                     /protein_start="489"
                     /score="38.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VLVTGGGSGLGRAFALALGASGANVLVAGRDEDALAKTVLDIRQT
                     GGTATPVTFDVTDQASVTRGVARATEEYGGLDVLVNNAGIAGPKGPLWAVDEGEWRRTV
                     EVNLFGSTNVIRAVLPALTGRVVNVVSRAGRVGWPNAGAYAASKAALISLTAS"
     aSModule        complement(3747..5615)
                     /domains="nrpspksdomains_AORI_RS68200_AMP-binding.1"
                     /domains="nrpspksdomains_AORI_RS68200_PKS_KR.1"
                     /incomplete
                     /locus_tags="AORI_RS68200"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(4137..4214)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS68200_0002"
                     /evalue="2.00E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="AORI_RS68200"
                     /protein_end="516"
                     /protein_start="490"
                     /score="10.8"
                     /tool="antismash"
                     /translation="LVTGGGSGLGRAFALALGASGANVLV"
     aSDomain        complement(4488..5615)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS68200_AMP-binding.1"
                     /evalue="3.60E-78"
                     /label="AORI_RS68200_AMP-binding.1"
                     /locus_tag="AORI_RS68200"
                     /protein_end="399"
                     /protein_start="23"
                     /score="254.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RSATARGDHLAVADLSRGDRREWTYTQLRAAVAGLATWLRLNGIT
                     DDDVVAVLTENSAEFVVAYHGILAAGGVVLALEPRDTGEHWRGKIDAGGAKALIAETAL
                     RPPEVEMPVVCVGAVTPGGAAWEEAVTIEPRLTHPPGGDRTAVLMSSSGTEGVPKLVPV
                     THRNLTSNLGQIDYLHRVRGDDVVLSVPPLRHIYGMQMAMNPALRAGATLVIGATPFSA
                     EDFLRDVTENEVSLSYLVPSVITELGKAGRRLPSLRMIVSGGAPLPTTDGARCAETLGV
                     PVVQGFGMTEAGCVSFSPDGVEVPPGSVGRLVPGTEVKFLGGEDGTEAGELCLRGPQIA
                     SAAADADGWLRTGDLVARDADGFLRITGRAKSLIKY"
     CDS_motif       complement(5121..5180)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS68200_0001"
                     /evalue="2.80E-03"
                     /label="NRPS-A_a3"
                     /locus_tag="AORI_RS68200"
                     /protein_end="188"
                     /protein_start="168"
                     /score="10.8"
                     /tool="antismash"
                     /translation="AVLMSSSGTEGVPKLVPVTH"
     gene            complement(5693..6367)
                     /locus_tag="AORI_RS68205"
                     /old_locus_tag="AORI_5443"
     CDS             complement(5693..6367)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027978.1"
                     /locus_tag="AORI_RS68205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5443"
                     /product="O-methyltransferase"
                     /protein_id="WP_016335766.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 6.3e-50,
                     bitscore: 168.2, seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 0.00016, bitscore: 20.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNTETQPAKAVPLTSEVLGYMRDQLPPFTEVQQELMDATLALGS
                     VAEMQVPPEQGALLTLLARLIGARVAVEVGTFTGYSTLALAEGVGQDGKVITLDITDRW
                     LDIASNAWTKAGVADRVEPVVGPAAESIEKLPEEPFIDLVFIDADKVGYLGYWEALVPR
                     VKPNGLIAVDNVLYAGEAASPDAEGNARAIREFNEHVLRDDRVESVMLTVADGLTLARK
                     KN"
     gene            complement(6364..7182)
                     /locus_tag="AORI_RS68210"
                     /old_locus_tag="AORI_5444"
     CDS             complement(6364..7182)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027977.1"
                     /locus_tag="AORI_RS68210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5444"
                     /product="hypothetical protein"
                     /protein_id="WP_063751885.1"
                     /transl_table=11
                     /translation="MTAQVIPRIVIPLPQERLTPCSEGEQAGPGALPRQSHASCARREN
                     TQPVPPPPAHSEIERAWYRWILGHHGSFVTWRLLSSALYHRDFDEAAALFDAYSALLLY
                     AGSCTPELYGTVVRPRMVARDPAMSGTWARDYRHINQQLADIVPARGSALKEAMKINRL
                     VHMSVAWRLVPAGGSLLRDSGHDVHDEPTLEEQDIVDDFFLLDRGPNCTSGFLVALRAR
                     ITAILADTHTRPVQAGYKHEAVNRFQEDLPVHIARVVSIAEATLLEGVNA"
     gene            complement(7179..8636)
                     /locus_tag="AORI_RS68215"
                     /old_locus_tag="AORI_5445"
     CDS             complement(7179..8636)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335768.1"
                     /locus_tag="AORI_RS68215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5445"
                     /product="aromatic amino acid ammonia-lyase"
                     /protein_id="WP_228688194.1"
                     /transl_table=11
                     /translation="MKLLDLAGHPLDVVLSDDAIARITRGRHFVEDVLGGDGRPVYGAT
                     TGFGPLVIFEGRDSATEQCDNVLQHLTVGQGADLPVPIARASVLVRALSLAQGLSGASV
                     STVDALCRMLSTGFAPAIPTWGSVGASGDLVPLAHAVQSLRGVGHAFVDGERMPAADAL
                     AAVGLTPLELDGRDALALVNGTSVTTAAAGLAALSAQRSVKVAIALTAALADLLGAVPA
                     FLAPSLLKAFGHPEVATTGEDLAWWLNETTPSQDRPLQEPYSIRCAPQLLGAARSAIGW
                     STQTVSQDLRGVSDNPLFFPDEDLVAHGGNFFGQPSAFASDLLSSAVTQIGNLAERQID
                     MLVDPGRNGGRPPMLAAEPGRHHAIQGLQVLSTSLVVAMRRACTPAAMQSVPTNLHNQD
                     VVPFGTQAALTAYEQAQKLRLLHGALGVAVRQAAHLDDRASTASRCTGLVAALSEEIDP
                     ITRDRPLDEDIRVAADVLDRHTQEVSP"
     misc_feature    complement(7374..7376)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    8734..8752
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.31"
                     /tool="antismash"
     gene            9011..9940
                     /locus_tag="AORI_RS68220"
                     /old_locus_tag="AORI_5446"
     CDS             9011..9940
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027975.1"
                     /locus_tag="AORI_RS68220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5446"
                     /product="hypothetical protein"
                     /protein_id="WP_016335769.1"
                     /transl_table=11
                     /translation="MNIALVTSSAFPGSDWSDRDTPILRASLNEQGCTTQILEWDDSDG
                     IDWTVFDVVAVQSPWSMWLKLTQFREWVDSLHRQGVRLANPHPVIVSGMSKEYLPEVEQ
                     HGARTIPTTVVRPGERIGAVAAETLARAERDFGEAAVVVKPISSGGTLGAARVTEEQDL
                     VARLAAFDEAGVTACVQPYVSSIDSLGEHGIIMIDGAVSHAITKDAILAPGREGTQFHP
                     NARAGYTEHGEDLTDIHNAYDAYLKTVPVHPVSVRLDFLRHPVTGRLLLLEIESVAPVK
                     FFHLHPAAAERYARSLITLAAASDLVRH"
     gene            10001..11275
                     /locus_tag="AORI_RS68225"
                     /old_locus_tag="AORI_5447"
     CDS             10001..11275
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027974.1"
                     /locus_tag="AORI_RS68225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5447"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_016335770.1"
                     /sec_met_domain="salQ (E-value: 4.9e-176, bitscore: 584.0,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 9.7e-65, bitscore:
                     217.2, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPKSPIPAGDAKEDSAPEAIAPPAPRKPITPRKIAPATDGASWHV
                     KASQPVNYEVRVCQDVFDPNRTDLLDAGGSGGNRTQRRFVVVDETVDSLYGPAIRQYFD
                     HHGVTYEIMVIQAGDVHKEIDVVLRLVERLDAFGIDRRREPVIVVGGGVVMDIVGLAAS
                     LYRRGTPFVRVPTTLVGLIDAGVGVKTGVNFNGHKNQLGTYSAATLTLLDRGFLSTLSR
                     RHISNGLAEILKVGLIKDEALFDLLERHGRLVLNENFQGRSPEGADAATAILEAAITGM
                     LEELEPNLWEETLERSMDYGHTFSPAVEMLGLPSMLHGEAVCLDMALSTALACRRGLVN
                     EDECGRVFAVMSDLELPTWSPLHTPEVLGSALHATVRRRDGQQRLPLPVGIGNTVFVND
                     VSDEELVAAIEFQREMATCSSTEVA"
     gene            complement(11294..12022)
                     /locus_tag="AORI_RS68230"
                     /old_locus_tag="AORI_5448"
     CDS             complement(11294..12022)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (1-107). E-value: 2.6e-08. Score:
                     25.9. Matches aSDomain:
                     nrpspksdomains_AORI_RS68230_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076261.1"
                     /locus_tag="AORI_RS68230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5448"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_016335771.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-29, bitscore:
                     101.7, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4.3e-29, bitscore:
                     101.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGGQGIGRAFAHALAEAGAKVAVIDLSADRADEVARELREKGA
                     EAISVQADAADETSVASFVRTTVQTFGRLDIAVNNAGINLNSAAEEATLEEWDMVHNLN
                     LRGVFIACQHEAKVMFPKGYGKIINTASMASMIVPHPQKQVSYNVSKGAVVSLTRTLAA
                     EWADRGIRVNCISPGIIRTALIEESEALAPLVDEWISNIPAGRLGEVGDLQGAVVYLAS
                     EVSDYMTGHNLAIEGGQTLW"
     aSDomain        complement(11702..12019)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS68230_PKS_KR.1"
                     /evalue="2.60E-08"
                     /label="AORI_RS68230_PKS_KR.1"
                     /locus_tag="AORI_RS68230"
                     /protein_end="107"
                     /protein_start="1"
                     /score="25.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TGGGQGIGRAFAHALAEAGAKVAVIDLSADRADEVARELREKGAE
                     AISVQADAADETSVASFVRTTVQTFGRLDIAVNNAGINLNSAAEEATLEEWDMVHNLNL
                     RG"
     CDS_motif       complement(11888..12019)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS68230_0001"
                     /evalue="1.30E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="AORI_RS68230"
                     /protein_end="45"
                     /protein_start="1"
                     /score="14.7"
                     /tool="antismash"
                     /translation="TGGGQGIGRAFAHALAEAGAKVAVIDLSADRADEVARELREKGA"
     gene            12005..13369
                     /locus_tag="AORI_RS68235"
                     /old_locus_tag="AORI_5449"
     CDS             12005..13369
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674385.1"
                     /locus_tag="AORI_RS68235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5449"
                     /product="Xaa-Pro peptidase family protein"
                     /protein_id="WP_228688195.1"
                     /transl_table=11
                     /translation="MPTTGHEGSPAIQSEPVQNRTGGGSLGAAKIFVHVFTHFWTKGKP
                     AVRHYTYLGRTVTGIHSRSVMDLPFDQSRMDTLMENSGADVVIATTRFSIQHLLGGYRY
                     FFFANLDAIGVSRYLPALVYIKGSPEKSFYIGCGNEEWGTSVFPLWVTDIRNQSWSSVD
                     TANSIVTGLREHGLDSSTIAVEKAFLPFDAAEVLRAALPEAAFVDAHPVLEAIRAIKSP
                     EELELVRTASVGIIESMSATFAASRPGETKIDIVERFRRAQTDRGLVFDYCLVSCGSEF
                     NRAPSSRVWREGEALSLDSGGMYQGYIGDLARMAVAGEPTALMRDLLAEVESVQQSVRA
                     AVAPGRRGGDIFDLADKALAACPHADEMFFVGHGMGLITHEVPRLTGTGPVPYPADHAE
                     APLEVGMVLSLETTLSNPDVGIVKLEDTLIVTEDGWEAPGDEARGWNRPLSGGGE"
     gene            13366..14121
                     /locus_tag="AORI_RS68240"
                     /old_locus_tag="AORI_5450"
     CDS             13366..14121
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027971.1"
                     /locus_tag="AORI_RS68240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5450"
                     /product="aldolase/citrate lyase family protein"
                     /protein_id="WP_123798549.1"
                     /transl_table=11
                     /translation="MSLRSRMVDGDPLLGLILKIPAHSAVELAGHLGFDFVLLDTEHSA
                     AETVEVEHHVRAGEAAGIPVLVRLAGKDPASALHALDAGAAGIVVPHVSDVADAEAAVR
                     AAHYPPRGARSLAVSTRAGRHGTVTLEEHLAKAARETVVVVQAEDRDSVRNCEAIAATE
                     GVDAVWIGPTDLSLSLGIPGDFDLAEYRSAVDRIVEAVGSAPQCALCALVDHPGKVEEW
                     RDRGASVLLFNYNTVVVEGLRAIVDSVRE"
     misc_feature    13372..13374
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14612..15028)
                     /locus_tag="AORI_RS68245"
                     /old_locus_tag="AORI_5451"
     CDS             complement(14612..15028)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007027970.1"
                     /locus_tag="AORI_RS68245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_5451"
                     /product="hypothetical protein"
                     /protein_id="WP_046199841.1"
                     /transl_table=11
                     /translation="MGVAYREKSAPVAVFESIAEYNIAYPHAQMPYLGDAHPRLRSFTC
                     AASGLWDDLTVSGYKYTLTFLPSGEPGPEREGVVVATRWGNPPVLLLARQVPLRWAWEV
                     VTKSWPTTLDSAARLLNTASRDRQSPGEVEVGQA"
     misc_feature    15972..15981
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     misc_feature    16258..16272
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.57"
                     /tool="antismash"
     misc_feature    complement(16621..16635)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.44"
                     /tool="antismash"
     misc_feature    complement(16653..16668)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    17365..17379
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.88"
                     /tool="antismash"
     misc_feature    complement(17607..17621)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.87"
                     /tool="antismash"
     misc_feature    complement(17726..17740)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    18299..18310
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     misc_feature    19200..19209
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    19725..19741
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
     misc_feature    complement(21181..21195)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
ORIGIN
        1 agccgccggc ggaaacgatg gcccggacgg tctcctcggc cgtctcttga tcgtggaacc
       61 agttgacgat gacgtgcgcg ccccgtccgg ccagttcgta cgagatggcc cggccctgcc
      121 ccttggaacc gccggtgacc aggcagatct tgtcgcgaaa gtcctggtca ctcacactcg
      181 cgccccttgg tgactcagct cgacgatcaa cccggcgatg gactcgagag tcgtgtagtc
      241 ggtgatccgg atgtggtccg cctccgggac gtcgtagcgc ttcctcgccc gctgcaggag
      301 ttcggtctgg cgaatggagt cgatgccgag atcggcctcg agttccacgt tgtcctcgaa
      361 gacatcggcg gggtatccga ccgcgtcggc gtaaagggtc ttgagctcac cgaggacctt
      421 ggtctcgaca aggcctcctt cctcgccggc cggttcgccc gaggccgagg tggcccgctg
      481 ggcgggcacc ggttcgacga caggctcggc gggagcagga gtcaccgcga caggagccgg
      541 agtgggtacc tgcgcggcgg gaaccggagc cggggcggca ggctgcgggt ccggcatggg
      601 ccgggcggtc tcggcacctg cgtcgagagc gcgtacttcg gccagcacgc ccgtgtcatc
      661 ggcacgacgg cggaacggcg cgctggtgct gatcccggcc agggtcgtcg tcgccaggtc
      721 caccaatgtc gaacgtgcgc cgcactcggc gaatcgggtc tcgccttccc cgcggatggt
      781 gtgcagtgcg tcgaggaagc gcacgggccg gaccagatgg ctcgacagca cttccaagac
      841 gtctccgggg gtttcgaccc ggcgcccgag aacgggtgag tggaccgcga tccgcggcac
      901 gcgcggggtg atcgtggtca ccgtgcgggc gaacagctcg ttggcccggc cgaggagctg
      961 gtggttgtgg aaggggtaag gcacccggag gacggtggcc ttgacaccca gcgcgcccgc
     1021 gacggccgcg agatgggcga cggccgtagt ggtcccggag accacgacct gatcgtaggc
     1081 gttgtccgcg gcgatggaga gactgcgatc cgccaccgct gcgacaagat gttccacccg
     1141 ccggaaaccg gcttcgacgg cgaccattcc cccggacgcc cccgaagccc tcaacgcccg
     1201 gtcacgcgcg accacgagcg tgaccccttc ttccagtgtc aaggccccgg aaaccaccaa
     1261 ggcggcgaat tcaccgaagc tgtgtccgac gagcaacgcc ggcgaaaggc cgaactcttc
     1321 tcgacaaagc cgtgcggcca cgatctggga ggcgaagatg gccaggctca atgccgggac
     1381 gtcattttcc agaagacggt ccaaggtggg cgacgcggga tcagtgagca gagacgccac
     1441 agcgggaccg cctgcccgca gcgaatattc gtccacctgc gataattcgt cggcgataac
     1501 gggaaaagcc tccctgcagg cgctgaacac accagccagg taggcaccct gccccgggaa
     1561 aagaaacgtc gaagtaagcg aatcatgctg cacagggact ccgggagact cggtccttaa
     1621 ggcgtttcac gccaaggtga tctgcgattc aggcgaaagc agactaacac gatcgcgtga
     1681 tggtcgaaaa atttcgaccc tttcctacag tgataaccga aaaacatgca gtgtcgtcac
     1741 cttgagtgag gtgatcgaac ttttcacgat acgaaaaccg ggcgccacct gcagtgacga
     1801 gggttcgtct cgccggaacc ggccgacatt gcgccgcgac gatgacgaac ggtaatcatt
     1861 cgcaagcggc ctcttccggc caatcaattc acggaccaga accacggatt gttcatccga
     1921 ctttgtccgc gaatgccttg atgacacttt tcgacacgag gacacgcatc caccgcgccc
     1981 tcccgcgaag gcagccggac gcagcagccc gtcgcagccg gcctcgttcg ccacacggcg
     2041 tggtgacgca tcgaacacca cgatgatgcg aacattcgtt cgatcatgtt gctccacgta
     2101 gtctcccccc gacggacaga gacctcagca agagcggtcg tgcagaatgt ccgaggacag
     2161 cgtgggaggt acgaggtgga gcgggaccgg gcggctcggc ctatccggtc cactcggtct
     2221 tccgcgggat ccgggttcgc gcggaccttg ttcccggatt cgcacgaggg atgccgggtg
     2281 acgacggccc tggcattgct gatgcaggga aacgatcggc tcgcgacagc agcacaggcc
     2341 gagatggtgc tcgccgacga ggtgtgcctg cggcatgcgg gctgtctgtg gcacggcgtg
     2401 acgattcttt tgcggaccgg cgagttcgag agcgtggacg cgcatctgtg gaaactcgag
     2461 agccgtcgcg acgacgggct cgccgatctc gtcgccctga tgcgggccga gcacgcccaa
     2521 tacgtcgggg acctgatggg ggcgagggag gcgctggagc gactggccac cacggcgtcc
     2581 ccgcccaccg tccgtgagct ggcggttcct tgctatctcg aagtgctcgt cgcggcgaac
     2641 gaacccgaca tcggcgacca ggtccttcgc gaccacgact tcggtcggct catgcgacgg
     2701 caggccctgc gcccgtttct gctggccgtt cgcggctacc tccacctggc agcgggccgg
     2761 gcggacgagg cgttgaagga cgcgctggag tgttcgcggc ttcctgtcac ggaagtggcc
     2821 gcccatttca cggtcgcaca ccgcaggggc ttgctcgcct tggccgcggc cgccgccgga
     2881 cgccccgaca tcgccggtcc cgcggcggcg cgcgagtacg aggccgccac ggcgtggcgg
     2941 tcgcattccc atatcgcctg ggcgctctat gtccttgaga tggtcgaggg cgagggccgt
     3001 ccgtccgacc ggctcaggga cgccatcgac ctgatggagc tcggccggtc cccggtcggc
     3061 ctcgccgcac tctgcttcga gcagggcagg agattcctgg aagccggtca ggagcaggcg
     3121 ggacgagccc tgctcctgcg agcggatgga gcggcccggc ggatcggcga caaggcgttg
     3181 agcggcaaga tcgagaactt gctgtgcgcg ctcacctcac cggccccgca ggcctccctg
     3241 accgcgcagg agctgaagat cgccgagctg gcacagaacg gctacaccaa caaacagatc
     3301 gcggagcgtt tggtgctcac cgtacgcacg atcgagttcc acctctccaa cgtgtaccgc
     3361 aaactcggga tctccggtcg gcgcgcgctg gccaacgagg ttctgccgcc tccccagtca
     3421 taggagcgcg ttcccacctg atcgcgcagg gttcactggc gaacgaggcg agaactcggc
     3481 agcggcgcca catcctccac ggacacatat cgcccgttca ggtgatccgc cgccccggtc
     3541 accacggcga ccagcgctcc ggccgcgtcc tcgaccgaag tgaaccggcc ggcttcacgg
     3601 gttttcagcg tccaggcgag gatctcgtcc tcccagctca ctcccgtccg accgcgatcg
     3661 agatgcgcct tcgtgatgcc gatgtccacc aaccccggat cgaacgccac cgccacccgg
     3721 ccggtttcgc cgaactcgcc agccaggctg gcggtcaacg agatcaacgc cgctttggac
     3781 gccgcgtagg cacccgcgtt cggccaaccg acccggcctg cccggctcac cacgttcacc
     3841 acgcgcccgg tgagcgcggg caagacggcc ctgatcacgt tcgtcgaacc gaacaggttg
     3901 acctcgaccg tccgccgcca ttccccctcg tcgactgccc acaaaggacc tttaggaccg
     3961 gcgatgcccg cattgttgac caggacgtcg aggccgccgt actcctccgt cgccctggcg
     4021 accccgcggg tcaccgacgc ctggtcggtg acgtcgaagg tcacgggcgt cgcggttcca
     4081 ccggtttgcc ggatgtccag aaccgtcttg gccagcgcgt cctcgtcgcg gcctgcgacg
     4141 aggacgttcg cgcccgaggc gccgagcgcg agggcgaacg cccggcccag cccgcttccg
     4201 cccccggtca ccagcacgcg aagggcaggc ggccgcgtcc gcttgccggt cgaagaccgc
     4261 gggatggcgc ccacccgctc gatcgcccgc acgcgtttgt acggggggac ccgctcggcg
     4321 acgtacgccg tgatttccgc gagcgcgatg ccttcggaga ggacgacgaa cgccttcggt
     4381 atctcccctg cgaccgggtc gggcagaccc gtgacgtggg cctcggacac ggcgggatgg
     4441 ctggtcagca cctcttcgag ctcggcgggc gagacctgat gtcccttgta cttgatcagg
     4501 gacttcgccc ttccggtgat ccgcaggaac ccgtccgcgt cgcgggccac caggtcgccg
     4561 gtgcgcagcc agccgtccgc gtccgccgcg gcggaggcga tctggggtcc gcgcaggcac
     4621 agttcaccgg cctcggttcc gtcctcgcca ccgaggaact tgacctccgt cccgggaacc
     4681 aacctgccga cggaacccgg cggcacctcg accccgtccg ggctgaaact cacgcacccg
     4741 gcttcggtca tcccgaagcc ctgcaccacc ggcacaccga gggtttcggc gcaccgggcg
     4801 ccgtccgtcg tgggaagcgg cgctccaccc gagacgatca tccgcagcga cgggagccgc
     4861 cgcccggcct tccccagctc ggtgatgacg ctgggcacca gatacgacag ggatacctcg
     4921 ttctcggtca cgtcgcgaag gaagtcttcg gccgagaaag gggtcgcccc gatcaccagg
     4981 gtcgcccccg cccgcagcgc cgggttcatc gccatctgca tgccgtagat gtgccgcagc
     5041 ggcggcaccg acaacaccac gtcgtcaccg cgcacccggt gcaggtagtc gatctggccg
     5101 aggttcgagg tcaggttgcg atgggtcacc gggacgagct tcggcacacc ttccgtgcca
     5161 ctggaactca tcagcaccgc ggtccggtcg cctccgggcg ggtgcgtcag ccgcggctcg
     5221 atcgtgacag cctcctccca cgccgcacca cccggcgtga ccgccccgac acagacgacc
     5281 ggcatctcga cctccggtgg gcgcaaggcc gtctcggcga tcagcgcttt cgcgccaccg
     5341 gcgtcgatct tcccccgcca gtgctcgccg gtgtcgcgcg gttcgagcgc gagcaccacc
     5401 ccgcccgccg ccaggatccc gtggtaggcc acgacgaact ccgcgctgtt ctccgtcagc
     5461 accgccacga cgtcgtcgtc ggttatcccg ttgagccgca accaggtcgc gagtccggcg
     5521 acggccgccc gcagctgcgt gtaggtccat tcacgacggt caccccggga aaggtccgcc
     5581 accgcgaggt gatcacccct cgcggtggcg gagcgcagga catagtcgtg gacattgacc
     5641 tcggcgggaa cgtcccacgc gacggccgac tgtgctggct ccatcggacg actcaattct
     5701 tcttgcgcgc cagggtcaaa ccgtccgcca cggtgagcat gaccgactcg acccggtcgt
     5761 cgcgcagcac gtgctcgttg aactcacgga tcgcccgggc attgccttcg gcgtcgggtg
     5821 aagccgcttc acccgcgtag agcacgttgt cgaccgcgat gagaccgttc ggcttgaccc
     5881 tcggcacgag cgcctcccaa tagccgaggt agccgacctt gtcggcatcg atgaacacga
     5941 gatcgatgaa cggctcttcg ggaagcttct cgatgctctc cgccgcgggt ccgacgacgg
     6001 gctccacgcg gtcggccaca ccggctttcg tccaggcgtt cgaggcgatg tccagccagc
     6061 ggtcggtgat gtcgagggtg atcaccttcc cgtcctggcc gactccctcg gccagggcga
     6121 gcgtcgagta tccggtgaac gtgcccacct cgacggccac gcgcgcaccg atcagcctcg
     6181 ccagcagtgt cagcagggca ccctgctccg gcggcacctg catctccgcc acgctgccga
     6241 gagccagggt ggcgtccatc agctcctgct gcacctcggt gaacggcggg agctgatcac
     6301 gcatgtagcc gagcacttcc gaggtgagcg gcaccgcctt cgccggctgt gtctccgtgt
     6361 tcgtcaagcg ttgactcctt ccaagagcgt ggcctcggcg atcgagacca cgcgagcgat
     6421 atggacaggc aggtcctcct ggaagcggtt caccgcctca tgtttgtaac ccgcctgaac
     6481 cggcctggtg tgcgtgtcgg cgagtatcgc cgtgatccgg gctcggagcg cgaccaggaa
     6541 tccactcgtg cagttcgggc ccctgtccag cagaaagaag tcgtcgacga tgtcttgctc
     6601 ttcgagggtc ggctcgtcgt ggacgtcgtg gccggagtcg cggaggagtg atccaccggc
     6661 gggcacgagc cgccaggcga ccgacatgtg cacgaggcgg ttgatcttca tcgcctcctt
     6721 cagcgccgaa ccgcgggcag ggacgatgtc cgcgagttgc tgattgatgt ggcggtaatc
     6781 ccgcgcccag gttccgctca tcgccggatc ccgcgccacc atcctcggcc gcaccaccgt
     6841 gccgtacagc tcgggcgtac agcttcccgc gtagagcagc aacgccgagt acgcgtcgaa
     6901 aagcgccgcg gcctcgtcga aatcacggtg gtagagcgcg gaggaaagca atcgccaagt
     6961 gacgaaagag ccgtgatgtc ccagtatcca gcggtaccag gcacgctcga tttccgaatg
     7021 ggccggcgga ggcggcactg gctgggtgtt ctcccgccgc gcgcacgacg cgtgagactg
     7081 acgcggcaac gccccgggac cggcttgctc cccctcggag cacggggtga gtcgctcctg
     7141 cggcagggga atgacgattc gggggatcac ctgggcggtc atggactcac ctcttgggta
     7201 tggcgatcga gcacgtccgc ggcgaccctg atgtcctcgt cgagcggtcg atcacgggtg
     7261 atcgggtcga tctcttccga cagcgccgcc accagaccgg tgcagcgtga agcggtcgaa
     7321 gcacggtcgt cgaggtgtgc ggcctgccgt accgcgacac caagggctcc gtgtaacagg
     7381 cgcagctttt gggcctgctc ataagcggtc aacgccgcct gggtgccgaa gggcaccacg
     7441 tcctggttgt gcaggttggt ggggacactc tgcatcgccg cgggtgtgca ggcccgccgc
     7501 atcgccacca ccagcgaggt cgacagcacc tgcagcccct ggatggcgtg gtgcctaccc
     7561 ggttcggcgg cgagcatcgg cggccgcccg ccgttgcgac cggggtccac cagcatgtcg
     7621 atctggcgtt ccgccaggtt gccgatctgc gtgaccgccg aggacagaag atcggaggcg
     7681 aacgcggaag gctggccgaa gaagttgcca ccgtgggcga cgaggtcttc gtcggggaag
     7741 aacagcgggt tgtcgctgac cccgcgcaga tcctgcgaga cggtctgggt ggaccacccg
     7801 atcgccgaac gcgcggctcc cagcaactgc ggcgcgcacc ggatgctgta cggctcctgg
     7861 agcggccggt cctgggacgg cgtcgtctca ttcagccacc acgccagatc ttccccggtg
     7921 gtcgcgactt cggggtgacc gaaagccttc agcaatgagg gtgccaagaa cgcgggcacg
     7981 gcgccgagca gatcggcgag agcagccgtc agcgcgatgg cgaccttgac cgaacgctgc
     8041 gcggacagcg ccgcgagacc ggcggcggcc gtcgtcaccg acgtgccgtt gaccagagcc
     8101 agcgcgtccc gtccatccag ttcgagcggc gtgagcccga cggcggcgag ggcgtcggcc
     8161 gcgggcatcc gctcgccgtc gacgaaggcg tgcccgactc cgcgcaggct ttggaccgcg
     8221 tgggcgagcg gaacgagatc cccgctcgcc ccgaccgaac cccaggtcgg gatggccggg
     8281 gcgaaccccg tggacagcat ccggcacaaa gcgtccaccg tggacaccga agcgcccgac
     8341 aagccttgtg ccagtgacaa agcacgcacg agcacggagg cccgtgcgat ggggaccggc
     8401 agatcggcgc cctgtccgac ggtcaggtgc tgcagaacgt tgtcgcactg ctcggtggcg
     8461 ctgtcccggc cttcgaagat cacgagaggg ccgaatccgg tggtcgctcc atagacaggc
     8521 cgtccgtccc cgccgagcac gtcttcgacg aagtggcggc cacgcgtgat ccgcgcgatc
     8581 gcgtcgtccg acaacacgac atcgagggga tgccccgcca ggtccaagag cttcaagtcc
     8641 agggaggcgg caggatcaag ggttgtggct gcgatctgag tcgggctcat ctggtcaatc
     8701 gtccccgtcg ctcgaggtgg cttggcgaag tagcttgcga ccgatcctct gccagcagag
     8761 ccgacctcag cgcatatccg cgcgcttcgt ccaacgcgat tgcccgaacg tccacgccgt
     8821 gtggccacac tggaccttcg ggttcccgtg gggcaaactc ctgcaagcaa aaaacttcag
     8881 tactcggcgc ggaccgacgt ctccggttcg cggaatcgct gtcgtggacg gttctcgttc
     8941 gcgcatcacc ttcggcttcc ctggcctggc gctcgtgaat cggcgcttgt gaactatcga
     9001 gaggcattcc gtgaacatcg cactcgtgac ctccagcgcc tttccgggca gtgattggtc
     9061 ggatcgcgac acccccatcc tgcgtgccag cctgaacgag cagggctgca caacgcagat
     9121 tctcgaatgg gacgactccg acgggatcga ctggaccgtg ttcgacgtgg tcgccgtgca
     9181 atccccgtgg agcatgtggc tcaaactgac gcagttccgg gaatgggtgg attccctgca
     9241 ccggcagggt gtgcggttgg cgaacccgca ccccgtcatc gtgagcggta tgagcaagga
     9301 atacctcccc gaggtggagc agcacggtgc caggacgatc ccgacgacgg tggtccggcc
     9361 gggagaacgg atcggcgctg tcgcggcgga aacgctcgcg cgcgccgaac gtgatttcgg
     9421 agaggccgcc gtcgtcgtca aacccatctc gtccggaggc acgctcggcg ccgctcgcgt
     9481 caccgaggag caggacctgg tcgccaggct cgcggccttc gacgaagccg gcgtcaccgc
     9541 ctgcgtccag ccttacgtgt cgtcgatcga ttccttggga gaacacggaa tcatcatgat
     9601 cgacggcgcc gtctcccacg cgatcaccaa ggacgccatc ctcgcgccgg gacgcgaggg
     9661 aacacaattc catccgaacg cccgtgccgg ctacaccgaa cacggcgagg acctcaccga
     9721 catccataac gcatacgacg cctacctgaa gacagttccg gtccacccgg tatcggtacg
     9781 gctcgatttc cttcgccacc ccgtcaccgg caggttgctg ctgctggaga tcgaatcggt
     9841 ggcacccgtg aagttcttcc accttcatcc ggcggcggcg gaacgttatg cccgctcact
     9901 gatcactctg gcggccgcga gcgacctggt ccggcactga cccttcaaca ggccacccgg
     9961 gcagaaatca tcgttacctg atcaagaaaa gagggcgagc atgccgaaat cgccgattcc
    10021 ggccggtgac gcgaaagagg acagcgcgcc ggaagccatc gcgccacccg cgccgcgaaa
    10081 accgatcacg ccaaggaaga tcgcaccggc gacggacggg gcctcttggc atgtcaaggc
    10141 ttcccagccg gtcaactacg aagtccgtgt ttgccaggac gttttcgatc ccaaccgaac
    10201 agacctcctc gacgcgggcg gctccggcgg gaaccggaca cagcgccggt tcgtcgtcgt
    10261 ggacgagacc gtcgacagcc tgtacggacc ggcgataagg cagtatttcg atcaccacgg
    10321 cgtcacctac gagatcatgg tgatccaggc aggcgacgta cacaaggaga tcgacgtcgt
    10381 gctgcgtctc gtggaacgac tcgacgcctt cgggatcgat cgcaggcgcg agccggtcat
    10441 cgtggtgggt ggcggtgtcg tgatggacat cgtgggcctc gccgccagtc tctaccgccg
    10501 cggaacgccg ttcgtcaggg ttccgacgac cctggtcggt ttgatcgacg ccggggtggg
    10561 tgtcaagacc ggagtgaact tcaacggtca caagaaccag ctgggcacgt attcggcggc
    10621 gacgctcacc ctgctcgacc gcggctttct ctcgacactg agccgtcggc acatcagcaa
    10681 cgggctcgcc gagatcctga aggtcggcct gatcaaggac gaagcactct tcgaccttct
    10741 cgagcggcac ggccggctgg tcctgaacga gaacttccag ggccgctcac ccgagggagc
    10801 cgacgccgcg accgccatcc tcgaagcagc gatcaccggc atgctggagg agctcgaacc
    10861 gaatctctgg gaagaaacac tggaacgcag catggactac gggcacactt tcagcccggc
    10921 cgtcgagatg ctcggccttc cctcgatgct gcacggcgaa gccgtatgtc tcgacatggc
    10981 gctgagtacc gcgctcgcct gccgccgcgg actcgtgaac gaggacgagt gcggacgagt
    11041 gttcgcggtg atgtccgatc tcgagctgcc cacctggagt cctttgcaca cgccggaggt
    11101 tctggggagc gcactgcacg cgacggtccg ccggcgcgac gggcagcagc ggctgccgct
    11161 gcccgtcggc atcgggaaca ccgtcttcgt caacgacgtc tcggacgagg aactggtcgc
    11221 ggccatcgaa ttccagcggg aaatggccac gtgcagctcg acggaggtcg cgtaaagccc
    11281 ggcgtcacaa ggcctaccac aaggtctgcc ctccctcgat cgcgaggttg tggccggtca
    11341 tgtagtcgga cacctcactg gccaggtaga ccacggcgcc ctggaggtcg ccgacctcac
    11401 ccagccgacc ggccgggatg ttcgaaatcc attcgtcgac cagaggtgcc agcgcctcgg
    11461 actcctcgat caaggcggtc ctgatgattc ccggtgaaat gcagttcacc cggatcccgc
    11521 ggtcggccca ctcggcggcc agcgtccggg tcaggctcac caccgccccc ttggaaacgt
    11581 tgtacgacac ctgcttttgg gggtgaggca cgatcatcga cgccatcgag gcggtattga
    11641 tgatctttcc gtaccccttc gggaacatca ccttcgcttc gtgctgacaa gcgatgaaca
    11701 cacccctcaa gttgaggttg tgcaccatgt cccactcttc gagcgtcgct tcttcggccg
    11761 cggaattgag atttattccc gcgttgttca ctgcgatgtc gagccggccg aacgtctgca
    11821 ccgtcgtgcg cacaaagctc gcgacagaag tttcgtcggc ggcatcagcc tggaccgaga
    11881 tcgcttccgc gcctttctcc cgcaattcgc gggcgacctc gtccgcacgg tccgcgctga
    11941 gatcgatgac cgccaccttg gcacccgcct ccgccagggc gtgcgcgaag gcgcgcccga
    12001 ttccttgccc accaccggtc acgagggcag tcctgccatc cagtcggaac cggtccaaaa
    12061 tcgaacgggt ggcggaagcc tgggcgccgc caagattttc gttcatgtct tcactcattt
    12121 ctggaccaaa ggaaaaccag ccgttcgaca ctatacttac cttggccgca cagtgacagg
    12181 aattcattcg aggagcgtca tggacctacc gttcgaccag agccgcatgg acacgctgat
    12241 ggaaaattcc ggcgccgatg tggtgatcgc gaccactcgt ttctccatcc agcacctgct
    12301 cggtggatac cgatacttct tcttcgccaa ccttgacgcg atcggcgtgt cccgatacct
    12361 tccggccctc gtctacatca agggctcacc ggagaagtcg ttctacatcg gctgcggcaa
    12421 cgaggaatgg ggcacttccg tcttcccgct gtgggtcacc gacatccgga accagtcgtg
    12481 gtcgagtgtg gacaccgcga actcgatcgt caccgggttg cgggagcacg gcctggacag
    12541 ctcgaccatc gcggtggaaa aggcctttct cccgttcgac gcggccgagg tactgcgagc
    12601 cgcgcttccg gaggcggcct tcgtggacgc tcatccggta ctcgaagcca tccgcgcgat
    12661 caaatccccc gaagagctcg aactggtgcg aaccgcctcc gtcgggatca tcgaatccat
    12721 gtcggccacc ttcgccgcgt cccggcccgg cgaaaccaag atcgacatag tcgagcgctt
    12781 tcgccgtgca cagactgacc ggggactggt tttcgactac tgcctggtgt cgtgcggcag
    12841 tgagttcaat cgtgcgccgt cgtccagggt gtggcgagaa ggggaagcac tctcgcttga
    12901 ttccggcggg atgtaccagg gatacatcgg ggatctggcc cgcatggcgg tggcgggtga
    12961 gcccaccgcc ttgatgcgcg atctgctcgc cgaggtcgag tcggtgcagc agagtgtgcg
    13021 cgccgcggtg gcgcccggcc ggcggggcgg ggacatcttc gatcttgccg acaaggcttt
    13081 ggcggcgtgt ccgcacgcgg acgagatgtt cttcgtcggt cacggcatgg gtctcatcac
    13141 gcacgaggtc ccccggttga ccggtaccgg cccggtgccc taccccgcgg atcacgcgga
    13201 agccccgctc gaagtgggca tggtcctgtc cctggagacg acgctgtcca atcccgatgt
    13261 cggcatagtc aagctggagg acaccctgat cgtcacggag gacggttggg aagcccccgg
    13321 agacgaagcg cgtggatgga accgaccgct gtcgggtggc ggcgagtgag cttacgttcc
    13381 cgcatggtcg acggcgatcc gctgctcggc ctgatcctca agatccccgc tcattccgcg
    13441 gtggaactgg ccggccatct gggcttcgac ttcgtgctgc tcgacacgga gcattcggcc
    13501 gccgagaccg tcgaagtgga gcaccatgtc agggcaggtg aggcagccgg gatccccgtg
    13561 ctggtgcgcc tcgccgggaa ggatcccgcc tccgcactgc acgcactcga cgccggcgcg
    13621 gcgggaatcg tcgtgcccca cgtgtcggac gtcgcagacg ccgaagccgc ggtccgcgcc
    13681 gcgcactacc cgcctcgtgg tgctcgcagc ctcgcggtga gcactcgggc ggggcggcac
    13741 ggcacggtca ctctggaaga gcacctggcc aaggccgctc gcgagaccgt cgtcgtggtt
    13801 caggccgaag accgggactc cgtccggaac tgcgaggcga tcgctgcgac cgaaggcgtc
    13861 gacgccgtgt ggatcggccc gaccgacttg tcgctttccc tcggcatacc aggggatttc
    13921 gaccttgcgg agtatcgatc ggccgtcgac cggatcgtcg aggcggtggg gtcggcaccg
    13981 cagtgcgcgt tgtgcgccct ggtggatcat cccggcaagg tcgaggaatg gcgagaccgc
    14041 ggcgccagtg tccttctgtt caactacaac accgtggtgg tcgaaggttt gcgcgccatc
    14101 gtggacagcg tgcgcgaata gccgacggag tggacgtgtc cggcccgcgc cttgagggac
    14161 cccggcacag tggccgatcc gccggggtcg tgtgtgacaa tgagcgttct attgaggggc
    14221 gagtcaaacg tggcgtgttc gtgatcgagg cctccgccgg ggtgaaagct cccttggccg
    14281 cgtccgacgc ggccaaggga gccttcgacc cggggtcgcg agtggcaatg ctcgttctat
    14341 tgaggggtag ggcaaacgtg gcgtgttgcc tgccaaggac tcgcctgtgg gaccagccgc
    14401 acctataact gtccataaag gacggctgcc tcgtcatccg tgaccggttt gcacgctttg
    14461 cgtggggggt cgtgagtggc gatggtcgtt ctaacgctct ttgtcactca cgaccccggg
    14521 taaaatcgga caaagagcgt caaccggcca ctcttccctc aggaagtgtc tcttgcggac
    14581 actgagacct cctcggcctc ggtgtccgga atcaggcctg cccgacctcg acttcgccgg
    14641 gactctgcct gtcacgagaa gccgtgttca gaagccgtgc cgcgctgtcc agtgtggtgg
    14701 gccaagactt cgtgacgact tcccaggccc accgcagcgg aacctgccgg gccagcagca
    14761 ggaccggcgg attcccccaa cgggtggcca cgacgacacc ttcgcgctcc gggcccggct
    14821 caccactggg cagaaaagtc agcgtgtact tgtagccgct gacggtcaga tcgtcccaca
    14881 agccggaggc cgcacaggtg aagctgcgca gccggggatg ggcgtcaccg agatacggca
    14941 tctgcgcatg aggatacgcg atattgtact cggcaatgga ttcgaacacc gcgaccggtg
    15001 cgcttttctc tcggtacgcc acgcccatgc ctccgaggat aggaaacgac gggcctggga
    15061 aggggcatac cgcgcgtgtt ctgcccgaag tggacaaacg ccgtatccga actacccgca
    15121 ttccattctt gagcggcgag gcaaaggtgg cgtgttgcga gagccgcttt cgcaacgtcg
    15181 gcggaggcgg gcggcgcagc tggtcgtgag tgttttgggt cgttagaacg acccaaaaca
    15241 ctcacgactc gtccccgaag gccgaccgcg cgtcgaagaa gacgtcccct tcctcgtcgg
    15301 gcggccgcag gccgatcgcg cccaggccgt cggagtccgt gcggaagtag atcacgtcgg
    15361 acgtggtccg cgagcgggtc caggcgggcg gtacggtgcc ccggtactcc ggggtgatcc
    15421 gccagtccgc ccgcgcccgc accaggtaaa gctgcccttc cgagcgcagc gtgtgttccc
    15481 cggtcttgcc gccggagccc gtcgacgccg actgctgcca ggcgagcatc gggccgactc
    15541 cgcgcacctc cggcagttcc acgacggacg ttccgggtac cagcccctgg gcgagactct
    15601 gccccgccgg cctggtcgtc ttccggggga agatgctcag cgggaacgac gcgaacaagg
    15661 tgctccacga cggaccggcc gtgcggtcct gaagggtctt tttcgcggtt tccccgctga
    15721 cggtgacttc cggggtggtg tcgtcggtgc ccttcagcgg ggtcacccac gtgtccgaca
    15781 gatcgacgtg aaacaccagt gcggacaacg gatggttttg caggaagccc gccgcgtaaa
    15841 agccgtcgtc cgccaggccg tccactcgat ggcccgcgtc ggtcaacgcg gcgggaaggc
    15901 cggtcgtgag agccgccgaa gacgtcccga cttcgacgac ccgtctggcg gcggccgctt
    15961 ccacgggcac cgaaggcggc cgtggcccgg attcttcggc gacagggaca ccttcgagga
    16021 tgtcacctac gacccgggcg accgcaccac ccggcacgtc caggtatgcc gtgtccggca
    16081 gcctggtgac gcgtccctgc gactgccctt ccatcagggt gtccagctga accctgctgc
    16141 gcgcggcgtc cggcaacagc agatcgggcg cgcggtgatg gatggcggcg ggggtcacca
    16201 gatccgtgag accgccggtg agcgaccgga cggaacgtgc caggtgggct gtcctggtga
    16261 acttcagttc gatgacgacg tcgtgacggt agacgacggc ctctccggcg gacgagaccg
    16321 tcctggtttc ttcggccgtc tcggtgtcgg tacggcggag cgtcgtaccg gcggacagtc
    16381 cactctggcc ggacatcccg agcccgcgca cggtcggccg cgacaggtag aacggcatcc
    16441 ggaaggatgc gttgccgctg tgcgaactca cgtcttcatg gaagctctcc tcggtcttgg
    16501 tcgacttggt ggtgagctgc tccgaccagc cgcccgccgg tcgcggatcg gtgccgtccg
    16561 ccggtttcgc ggtcgcggtg agctgatggg tgatggtgcc cagaggaccg gtgaacgacg
    16621 cggaccacgt cttcccgccg agggtcagcg tccggaacag gctttccagc gcacgcggtg
    16681 aaacgtcggc gcgaacctgg tcgagcaggc gcgccccggc gacctcgtca ccggcgccga
    16741 acaccaggcg gtgcgccacg tcgccgatgc cggtcgcgaa agccgcccag ccactcgcgg
    16801 tcgcgctcgg cgcctggaac gacttcatct cccgctccac ggcggaaacg agttgcccgg
    16861 tgacctcggt accgaggctg accggcgacc gcccgtcgta ccccagggac ggaggcggtg
    16921 cgatggacgg cgtggcgggc tccgaaacgg cggggaagcc gtcgtcccag ccgtggggca
    16981 ggccgagccg gtcgatctcg gcggcgggca cccagacctg caccgcgttg cgccgatgcg
    17041 cctgcgcgta gttccagccg ccgtcggtcg tcccgtcgta gggtccgacg ccgagatggc
    17101 gatagtcccg gccggcgagg agcacagtcg cgtcgtaggt cacgaggtag gcgtcgccgt
    17161 cataggtggt tcgcctggtc tgttcgtgct ccacgcgcag cgaatgcccg tcggcggtgc
    17221 tcccgtagaa cccgtagccg ccttgcggaa acgcgtacgt gctcgcctgc cgatcggccg
    17281 cgatgccgag cctgccgttg ccgtaggtgt agccaccgga cgtgctccag cccccgtggg
    17341 cgcgggcgcc gcccgcggtg ctggtgaacg tcagcttcat cttccgcggc ggaccggccg
    17401 ctcgcgcgtt gccgaggacg atcgccatgc cgacgtcgcc gatacgatcg cggaacccga
    17461 gatgctgccc ctcaccacgg ccgtagcggt gcagcggcgc gtggtaggtc ccgctgaccg
    17521 cgcggtcgag attcgcggcg acccggtcgg gccccgcgaa ccggaacagc tgatgcgagg
    17581 cgagatgctg gcccttgccc aggccgccga acagatcgtc cgacaggaag cgggcgatgc
    17641 ccggaggcag gtcgagaccg tggaccgcga agtgatccgg caggttcgcg gacgtccagc
    17701 cggcaggccg gctcgctgtc gcacgatcga catgggtgaa cgaggtgttg ccttctgtgc
    17761 tcggtggcgt gaaggagatt tgtccactca ggactgtttc ggtttcgccg ccggtgacgt
    17821 ggaaggtctt cgagccttgg tcgtcgaaga tggagacctt gtagtcgacg tcacgccggt
    17881 gggtcgtgct gccgtcggcc gaccagctct gcccttgcgc ctgcgtgtcg acggtttcca
    17941 gagtgcgcgc cgagttggcg aacgaacggt tcgcaccacc gctcacctcg tagctgcgga
    18001 cggtttcccg tgagccggca ccgacccgga cacccgcgtt cccgccgagg gtcaccgacc
    18061 cctcgacgga gtcgttgtgc tgagccttgc gtttcgcggc gatctcaccg ctgagccctg
    18121 tcgcggagaa cgtggggccg ccggccggtg tccgccctgc cctcggcgcc gggacggtct
    18181 cgatgaccac gtgcagcagt tcgttcgatc ggttgctgcc ccgatgggtc tcccggacga
    18241 gcaggaacga aaggccgtca ccgttgaggt ccggggatcg agcggtgagc cccgccgggg
    18301 acaggaacgc gtcgaccagt gcctcgttgt cggcggtcgc gccatggccg tccttctgct
    18361 ccggctcctg cagcaccccc ttgggcagct gcgcccgcag ttgtgccttc aaccgttcgg
    18421 cttgcgggta ccgggtttcc gccgcgccca gtaccttgcc cgccacgaac ggcgcggtga
    18481 cacgcgattc ggacacctcg gccgtgtcct tgggctggac cgaccatctg gtcgccccgt
    18541 ccgtcaccgt gtgacttccg gtgaactcct tgccgtcgtc gaagcgtgcg tggatctcgt
    18601 aggtgacgtc gctgatcctc atccgcaggt cgccggactc ggatgtggaa gtggaagcgg
    18661 tgacctcgtc ggaggcggtg agttcccgcg actcggaggc ggagcggaac gccatggcgt
    18721 cgaacctgag atccagccgg ttcccgaaga cgacactggg ttgctcgtga atgctccaca
    18781 ggaagcccaa tcccagcgag gcgttgacgc tgaaggggct ccggctggcg gcggtgaccg
    18841 attcttcgcc acgatgtccg cgcccttgtt tgctgacgga cgaggactcc tcgctctctc
    18901 cggtggcgaa atggcggtgg ttgcccatcg tggcgctgag ttcgacggtg gcgttccgca
    18961 agcggccaag cgagtccggc agctgcacct tcgtcaccac cttggcgcct ccggccagtt
    19021 ccgtgccggt tcgcgagagc gcgccgctac tggtgatgtc ctgcagcgac gagcgcagcg
    19081 gagagccgat cacattcgcg gcgccggccc agtcggaatg ccggtgcagc acaccgccca
    19141 cggcggtgag caggccttgg tcgccgcgca ggaaggtcgc tcgtggtccg gtcgagaccg
    19201 aaggcggcgc ctcgatctca cgaaggtcgc cgaggatctc cgggctgctc aaccggacgc
    19261 cgccggactg gttgcctcgc cggtgcgcgg cgggctcacc ggtccgcgcg aggacgattt
    19321 cgtgctgtag gtcgaacggt ttgcccgtcc acttgtccgg cggggtgacc gactcggagg
    19381 cctgggtctc ggtggtgctc gacgtccgcc atgagggtgt ggaagtgatc cccttgatgc
    19441 cgacggccgg atcgaccgtg cggaaggctc cgggatcctg ggagatcggc aacgacaggt
    19501 agtgcccgaa ggcgccctgc ctgcgcggcg ccgaggccgc gtcgttcgtc gccgcgcccc
    19561 ggttgcccgt ggcgacctgg tcggacttgc gcgcgggatc ctgcggtccg gtggtgaccg
    19621 tggtgtcggc cgaagtgttg tcgccgggtt cgccccgcac gacgatttcg acggcgtctt
    19681 cgccatgccc gtcgacgacg aggtagccct cgtgagcgaa ctgcttgtag ttgtccttga
    19741 gggccaggtc ggtcaacgca ccgaggatcc tcgtcacctg cgcgggcggg gcttgggcgg
    19801 cctcgagcat cgccttgacg tcggcccgga tcgccgagcc gtcgaccgcg gtcgcgagca
    19861 cgctgttcgc cgccgcgagc ctgcggacat gctgggtctc ggcgctcggc tgcccgggga
    19921 gggtgagcgg ggcgagttcg atggccggtt gcaggaacgc catcgccgcg aagctcatcg
    19981 gatccgtttc ggacggctgg gtctcggcag gggctcccga cagatcttcg gacaccgtct
    20041 gcgggactgg agcggaactc gcgtcggtgc tctgctgcat gggcgacgag gacgcttgct
    20101 gcccgaccga ggtgttctcg gtgaacgggc tttccgagcg ctcgggggcg accgaagagg
    20161 gaccggcctc tccctcggca ggtccgtctg cgacggccac aaggcccact cccgccggtg
    20221 ccaccggcgc acctcccggc agaccgccgg gccgcgctgt gcccagcttc tcggccagtt
    20281 cggcggaccg ctgtcgtgcc acggcctcgc cgcggcgatg cacgtccgcg gcgacgacga
    20341 gccggaggtc tccgatcagg ttctgccacc tcaccagcgc gggatccgtc tcggagcgga
    20401 tcaacggggt ccggtgatac cgggagacga tgcgcgccgc gtcgctcagc aagccgtcgt
    20461 agcgcgattc gctgaccttc cccagtgaca gcgccgcctc gtccgccgcg aggcggacct
    20521 gctcaagcat ctccgcgggc acactcggcg gttcctgcgg gccgatgctc cgtaccttct
    20581 ccgacagggc cggaaaatcg atcttgaggt ccgggatcgt caccggcacc gaacccacgg
    20641 ggccctcgcc gtgggcaccg gacacgccac gtgcgccacc caccgacccc aaggctccga
    20701 gcatgccgtc cgcggcgccg cctttgacac ccgtcgacag attcgagaac acggtgccga
    20761 gcggggtcac gagcacctgc gcgaacgcgt agccggtatg tcccgccgcg atcacgtgcg
    20821 gggcgaaggt cttcgatcgc gtctgtgcgg accggccgag gaacctcagg cccactgccg
    20881 cgccgtgtgc cagtcccgcg accgctcccc cggtcacacc ccccagtacc gaaccgccca
    20941 ccgaagacca gtcgaggttt tcccggtccg aaaagaccat ttgcccggtt tggattccga
    21001 gatcgagccc gcccatgacc gctccaccga tggccgcgaa cttgaccgtc ttcccggcca
    21061 ggctcaccat cgccgtgccc gcttgccgga tggtgagctg ctgaaccttc gtcaccagat
    21121 gacgcagcac ctcacgcatc gaaatctgtg ccgccagtct cgcggccggg acgagaaagg
    21181 agaaaatgac ggtcgcgagc aagtgcgcga tcatcgcgaa gaccatcgcc gccatggcga
    21241 tcaggaggat tttgaccttc tgcacgtcca gtgcc
//
