LOCUS       NC_021252              22871 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4513543
            Orig. end                         :: 4536414
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22871
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="18"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22871
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22871
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12871](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12871
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    469..483
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    complement(655..670)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.28"
                     /tool="antismash"
     misc_feature    complement(753..768)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.09"
                     /tool="antismash"
     misc_feature    complement(814..832)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.99"
                     /tool="antismash"
     misc_feature    818..831
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(994..1956)
                     /locus_tag="AORI_RS61550"
                     /old_locus_tag="AORI_4120"
     CDS             complement(994..1956)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AORI_RS61550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AORI_4120"
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /protein_id="WP_043848848.1"
                     /transl_table=11
                     /translation="MLRIHFTPEDLARTRISAAPQPMWEILLSMYRLRGREGGVIFEEW
                     RRSVAQAAHVTTRLLADLASQSGYAVDFLTPTLRNLSLAEGLEALRRTPKKRLRTDLTV
                     LAGSRRLPSWTTGLAEGRPETLTQLADSVERYYTACLAPYWVRVCGRVEQVRARQVKTM
                     TEEGCEALLAEVHPTARWTYPVLELDYPVEHELRLNGRGLCLTPSFFCWGLPTTFLAGE
                     LEPTLVYPIEHKVGWSANGAAHRPLTSLLGRTRARVLEAIGESPGTTTEVASRTKTSLP
                     TASQQAATLRAAGLVTSRQAGQSVLHSITPLGLALLAEG"
     misc_feature    1936..1951
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    1938..1952
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.36"
                     /tool="antismash"
     misc_feature    complement(1986..1999)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    2144..2159
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 24.29"
                     /tool="antismash"
     misc_feature    2144..2160
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 23.5"
                     /tool="antismash"
     misc_feature    complement(2163..2174)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.0"
                     /tool="antismash"
     gene            2207..3205
                     /locus_tag="AORI_RS61555"
                     /old_locus_tag="AORI_4121"
     CDS             2207..3205
                     /GO_function="GO:0042834 - peptidoglycan binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334459.1"
                     /locus_tag="AORI_RS61555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4121"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_016334458.1"
                     /transl_table=11
                     /translation="MRTTAASVLAAVLVLCGLLQPVSRLAHAEPDLHAAGHPTADLKLT
                     RDDILTRAKSWLDERVPYSQEAKHTNQYGTYRQDCSGYVSMAWGLKTARWTGDIMQVAT
                     RIDKKNLLPGDSLWVHSSAHQHMALFIRWADTAKTQAVVWEEYRSGTVASQRTWSADRT
                     AGFTAIRYRNVVEGDAKTCAAVSLDHPRYPEIAAAATGALVKAAQCLLTAAGFPTGANG
                     PTGTFDTTTADATKQFQASLGLAALGKVDSHTWTALLARGTTPQLQDGASGDAVLRLQR
                     ALNAALDAGLELDGRFGANTTAAVKRYQSAHGLTSDGIAGPKTWAALQAGK"
     gene            3238..4371
                     /locus_tag="AORI_RS61560"
                     /old_locus_tag="AORI_4122"
     CDS             3238..4371
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018983.4"
                     /locus_tag="AORI_RS61560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4122"
                     /product="peptidoglycan-binding protein"
                     /protein_id="WP_016334459.1"
                     /transl_table=11
                     /translation="MRVKTAALGMAMMVAFGLATANQATAATAADPTGAELSAVVATCA
                     QQVSAGKYAERSGGTRTVPVCATGGAVHWRSGMTIDCDGQRTEKCNASTDPSWQGQTAW
                     AQPDGKPLNAEKLPYIVVPGISSTWSYAGSGITGATVAAVVYQGKVAYAVVGDVGPTGA
                     IGEGSYALAKALGINPDPRSGGVSGKVVDYIVFPGVKASPIHDAADAATEGRRAAAELV
                     SRSRGCANAGVDGPYPRLDAGVTRPEVKAAQCLLRAAGQDTGAGDPSGVLDAATVSAVK
                     RFQAQVGLAETGSVDSHTWTALLARGATPQLQDGSSGEAVFRLQRSLNAAISAKLTVDG
                     KFGAKTTAAVKGYQTSRGLNADGIAGANTWRALQAGR"
     gene            complement(4408..5073)
                     /locus_tag="AORI_RS61565"
                     /old_locus_tag="AORI_4123"
     CDS             complement(4408..5073)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028740.1"
                     /locus_tag="AORI_RS61565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4123"
                     /product="response regulator transcription factor"
                     /protein_id="WP_016334460.1"
                     /transl_table=11
                     /translation="MIEVLVVDDQDLVRAGFVALLRAAPGITVVGEAADGQEAVDLAAR
                     LRPDVVLMDIRMPGTNGVVATERILAAERDRPTRVLVLTTFDLDEYVYAALRAGASGFL
                     FKDVRAERLVAAIHTIAAGEQLFAPSVMRRLIEAYANRPGGPTGAPGPELDCLTARETE
                     VLRLVGKGMTNGGIAGELVVSESTVKTHVNRAMTKLGLSSRAQIVALAYESGLVTPGA"
     gene            complement(5070..6200)
                     /locus_tag="AORI_RS61570"
                     /old_locus_tag="AORI_4124"
     CDS             complement(5070..6200)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="AORI_RS61570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4124"
                     /product="sensor histidine kinase"
                     /protein_id="WP_016334461.1"
                     /transl_table=11
                     /translation="MGDAVLAVFMIAFTIEAGFAVGLPGFRPFDSTGVLLSVLVNAPLA
                     VRRRAPLTVFVLVLAGWAGYLLPGYWPGVSALALLLGLYTVAAYRSLPVTALCAAATLA
                     GETYSACHAQLIGSVWTAVFQSVLLTGVAWGFGANAGRLAQRNGQLRMLTEQLRREQED
                     RARRAVTEERVRTARELHDVVAHHMSVIAVQAEMARYVFESDPAASRTALDVIGRTGSE
                     GLDELRRMLTVLRSGEDDDTYVPAPGLEGLKELAARVGAAGVHVEVSVRGTVRSLPDGV
                     GLCVYRVVQEALTNVVKHARPARAWVSLTYGAEDVTVRIADDGRSERFHEGAGHGMIGM
                     RERAELYGGTLLAGASAEGGFVVTLVLPLAAGGVGS"
     misc_feature    complement(6339..6355)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.37"
                     /tool="antismash"
     gene            6722..7258
                     /locus_tag="AORI_RS61575"
                     /old_locus_tag="AORI_4125"
     CDS             6722..7258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005168292.1"
                     /locus_tag="AORI_RS61575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4125"
                     /product="hypothetical protein"
                     /protein_id="WP_016334462.1"
                     /transl_table=11
                     /translation="MSKLPPKPADSAPLRERIAWEALQKVTRFAHRLDPAARSSCPAFD
                     PGRTTTVTCTVTYLGEGYDYVLRDIKFQGTGLTNGRTEQGTVSYKADLTAGPIIRDQVE
                     SVLRYQNSTEYAACDMREHVRFGFDSTRRRPSGSSVVGEWIYVPGISCRYLDSKARAVK
                     AIPLELYDWGAPIHP"
     CDS             complement(7586..7771)
                     /gene="allorf_4521129_4521314"
                     /locus_tag="allorf_4521129_4521314"
                     /protein_id="allorf_4521129_4521314"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLPAEGSPAGPAAPATVRKGWRPRHSCPVCALCVGVREPDITTST
                     GRAIGAHCPLWTLYAG"
     CDS_motif       complement(7742..7771)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLPAEGSPAG"
                     /locus_tag="allorf_4521129_4521314_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7586..7741)
                     /prepeptide="core"
                     /locus_tag="allorf_4521129_4521314_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="5275.1"
                     /monoisotopic_mass="5271.7"
                     /core_sequence="PAAPATVRKGWRPRHSCPVCALCVGVREPDITTSTGRAIGAHC
                     PLWTLYAG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLPAEGSPAG"
                     /leader_location="[7741:7771](-)"
                     /alternative_weights="5293.1"
                     /alternative_weights="5311.1"
                     /alternative_weights="5329.2"
     gene            complement(8510..9742)
                     /locus_tag="AORI_RS61585"
                     /old_locus_tag="AORI_4127"
     CDS             complement(8510..9742)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634756.1"
                     /locus_tag="AORI_RS61585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4127"
                     /product="acetyl-CoA hydrolase/transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_016334464.1"
                     /transl_table=11
                     /translation="MRVLSESQLGSVLAGVPASCPRVVVSGNFATPMRALKVLDAALAE
                     YRLFALNAQAGMPDREGVLLETPFVGAGMRGRSGLRYFPSRLSLVPQLLKHSLPPDVVL
                     LHTSAPVGGVVSLGTEVNILPAAIEAVRARGGLVIAQLNPEMPFTYGDGLVPVDEIDYG
                     IEVEEPLLSPVPRPVGDTARTIGERVAGLVEDGATLQLGIGGIPDATLAAVTGRRGLAI
                     WSEMFSDGVLALDRAGALDPAEPVTASFVFGSADLYRWLDRNPRIRLLRTEKTNDPAVI
                     ARQRGLVSVNSALEVDLYAQANASRVRGAIYSGFGGQTDFVVGALHSPGGRAIIALPSW
                     HPKADVSTVVPRLTGPVTSFQHSFVVSEHGVATIWGNDASEQARQIVGQVAHPSAREEL
                     VARGRELGFAL"
     gene            10001..12871
                     /locus_tag="AORI_RS61590"
                     /old_locus_tag="AORI_4128"
     CDS             10001..12871
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029581.1"
                     /locus_tag="AORI_RS61590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4128"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_016334465.1"
                     /sec_met_domain="DUF4135 (E-value: 9.7e-98, bitscore:
                     326.7, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.3e-13, bitscore:
                     48.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQPSATSLPPRWWEHGRTPRERSADKPLWADFAEHAITTLLPE
                     RPPVGDWRAAFAGVFRSLVDAASRDAVPDDLPGADVDALRQGFAANLDQHLLNLSVRTL
                     VLELHRARKAGTLQGETPEERFSDFVRSQSTPAGLIRLFGEYPVLARLLAQACLYAAEA
                     HAETLARFSADAALLPCSVVDGALGTLVEVAGGFGDSHACGRSVKLLRFSSGAKVIYKP
                     RPLVLHERFTDVVEQLNKRLPGLELRTADALPRDGYGWLRFVEHRPCADLGDVDRFYRR
                     QGILLALLHALDATDVHYENVIACGDQPVLIDIETLFQPSPPVPPEGDPAAAMLARSVQ
                     RTLLLPQLFAGEHGAVDISGLAGRGGKLPTDRVDWADAGTDRMRLVRVPGELAGSNNLP
                     RLDGRDVAPAEHSAALLAGFRLGYDAISSGREELTELLRRCAEDPIRVLIRPTNFYSRL
                     LDETTHPDLLRDAADRDRAFDLLEEDSVREEKLLRLVPHERDDLWAGDVPMFTSNPGST
                     SLLDSRGDSVEGVVDRPSLDTVLAKVADMDPLDQRDQEWLITATLAISTAADGHHSNGE
                     TAETAVPNQAPDAERLLVTACGIADQIVANAFSDEHRSNWLGIELVDDRYWTVLPMGAG
                     LGEGYCGVALFLAQLAELTGIARYRDLAAYAISPLPGLFATLRADRELAATAGCGGLLG
                     LGGVAYTIARLSTLVGLPAGDLIEQAVDLMPEATAETPSGFTTGLAGGVASMRSVYVQT
                     GLETALARADRYATQLLERERPAEKSFARGSAGIDWVLRAHERPGEEPPGKADDRAEST
                     GGWCDGLAGDALGTAAHLPDPEHARDLDRTIRRLTDRAPLKDLSLCHGESGVLDVLCVL
                     AENGHTGAAAAARRRTGHLLAAIDQRGARCGTPGAVPSPGLLSGLAGIGYGLLRLGFGD
                     RVPSALLLRPDRPHPAATVFPPVNRV"
     gene            12885..13079
                     /locus_tag="AORI_RS61595"
                     /old_locus_tag="AORI_4129"
     CDS             12885..13079
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029580.1"
                     /locus_tag="AORI_RS61595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4129"
                     /product="hypothetical protein"
                     /protein_id="WP_016334466.1"
                     /transl_table=11
                     /translation="MYERDLPATEDVLGAVNLPRALEVGSRNHALAGSKPRLSANPLAT
                     LSTDTGSPSVVSVFTGGWI"
     gene            13169..16057
                     /locus_tag="AORI_RS61600"
                     /old_locus_tag="AORI_4130"
     CDS             13169..16057
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029579.1"
                     /locus_tag="AORI_RS61600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4130"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_016334467.1"
                     /transl_table=11
                     /translation="MGIRSSRMIGRDAELAELSGALDRAIAGRGGAIFLVGEGGVGKSR
                     LAIEAASRAVAADVPVLQGRASSIGPLVPFRPLTQALLSHFRGGGPPEATELDPFIPVL
                     AQLIPDWSRGDRPRESGSLMVLAEAVFRLLAVTSRDRGALLVLDDLQDADAETLFILEY
                     LVDNLPAAQTLFVGTLRSEPSDALRLATSGAQRMSCAVVELGRLGLADTHALAAACLET
                     EPGRLPSAATELLWRNSAGLPFIVEELLHGMVNDGLLVEGRDGWRVIGELRARVPAALV
                     TSIGVRMEQLGEQAGELLSVAAIIGRRFPLTVVQAVTGTNDRTLHNHLGAAVSANLVTT
                     DEMTPGWYAFRHPLTAEALLARQSPARKAELARQTADAVEELYPGLPGDLCALVASLRL
                     TALDERAAGRLFAETGRRALDAGAADSAVTMLTKALDLLAGADAGDRAEVLETLVHALG
                     QTGQFDRAVELSAAFGEIGTLERAAKLRTQLAWAAYIAGRHDECLGQIERARAPLGSAI
                     SPAQQAALDAVEANLWLDVPGRTGTAERLARQAWKVAEATEQPFVVCQALQVLGMLALS
                     RDLSESEHYMQLARRTAEDNHLHHLRTQALVRLGGHRVLMNGDEQTLLLARADAQRTGS
                     ITLHCAVDSVRTMHAILRCDFGTAHTLLAENLAVLGRLRLTALLQYAHMTRAMSAGHRA
                     DRPAMEQALDDFRESGGENAQEMVLSIGLARVFCSLLEEDFDRARRELGQVIELEDRRP
                     SRFHLAGQHGLRTLVDTLGGAPCPDGGSAVSGMRWNRQFVEFAQAVEHGRRGDAAEAER
                     AVASALETSAPYPLARHLGLRLIAEPAAADGWGDPAGWLKEAEEYFHGRDIQAVAAACR
                     TLLRKLGAPVRQRRSGVDRVPGDLRAAGVTVREYEVLVLLAERMGNKDIGARLHISPRT
                     VEKHVASLLAKTGLADRAALAEHAAGPRPGML"
     gene            16061..16300
                     /locus_tag="AORI_RS61605"
                     /old_locus_tag="AORI_4131"
     CDS             16061..16300
                     /GO_function="GO:0015035 - protein-disulfide reductase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334468.1"
                     /locus_tag="AORI_RS61605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4131"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_016334468.1"
                     /transl_table=11
                     /translation="MSDLIVYGAGWCPDVKRSRALLDSKGVEYAYIDVEADSGAEETVR
                     ALQNGERRIPTIVWPDGTHLVEPSDDELTAHLNR"
     CDS_motif       16061..16087
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSDLIVYGA"
                     /locus_tag="AORI_RS61605_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16088..16300
                     /prepeptide="core"
                     /locus_tag="AORI_RS61605_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.70"
                     /molecular_weight="7675.4"
                     /monoisotopic_mass="7670.9"
                     /core_sequence="GWCPDVKRSRALLDSKGVEYAYIDVEADSGAEETVRALQNGER
                     RIPTIVWPDGTHLVEPSDDELTAHLNR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDLIVYGA"
                     /leader_location="[16060:16087](+)"
                     /alternative_weights="7693.4"
                     /alternative_weights="7711.4"
                     /alternative_weights="7729.4"
                     /alternative_weights="7747.4"
                     /alternative_weights="7765.5"
                     /alternative_weights="7783.5"
                     /alternative_weights="7801.5"
     gene            16297..16512
                     /locus_tag="AORI_RS61610"
                     /old_locus_tag="AORI_4132"
     CDS             16297..16512
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005168317.1"
                     /locus_tag="AORI_RS61610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4132"
                     /product="hypothetical protein"
                     /protein_id="WP_016334469.1"
                     /transl_table=11
                     /translation="MTLPDVPVGTRVVVRYRIEGGFTDALGYLRSRDETECTVETKRGL
                     ATIRLADIVLAKTVPPPPAPRSPREG"
     gene            complement(16608..17489)
                     /locus_tag="AORI_RS61615"
                     /old_locus_tag="AORI_4133"
     CDS             complement(16608..17489)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334470.1"
                     /locus_tag="AORI_RS61615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4133"
                     /product="manganese catalase family protein"
                     /protein_id="WP_016334470.1"
                     /transl_table=11
                     /translation="MFRHTKSLQFEAKPEKPDALYARKLQELIGGAYGEMTVTMQYLFQ
                     GWNCRIEGKYKDLIMDTATEEIGHVEMLATMVARLLEGAPATTVAEAAKDPATAAILGG
                     MDPQQAIISGGGATPSDSQGYPWNGRYVVASGNLLADFRANAAAEAQGRLQTARLYNMT
                     DDPGVKAMLQFNLARDTVHQKQWLAAIEELKADGLESDIAPTALFDEENQDHNNTVWHL
                     SDGPDGAKGGWSFGEDGIEYLMEPEALGGPGTAPKPDPALYGTYAPLQDAVGTIKGKAK
                     DAKKKATKSQKS"
     gene            complement(17521..17976)
                     /locus_tag="AORI_RS61620"
                     /old_locus_tag="AORI_4134"
     CDS             complement(17521..17976)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466936.1"
                     /locus_tag="AORI_RS61620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4134"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_016334471.1"
                     /transl_table=11
                     /translation="MTASPATVRRAPRQLIALAVGAVFLLVGILGFIPGITTNYEQLSG
                     AGHESGALLLGVFQVSILHNIVHLAFGVAGILLARTVSGAKAFLVGGGVVYLVLWLYGL
                     LIDHGSAANFVPVNSADNWLHLGLAVGMIALGLIPLSGSKAPIADSR"
     gene            18143..18811
                     /locus_tag="AORI_RS61625"
                     /old_locus_tag="AORI_4135"
     CDS             18143..18811
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029571.1"
                     /locus_tag="AORI_RS61625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4135"
                     /product="hypothetical protein"
                     /protein_id="WP_016334472.1"
                     /transl_table=11
                     /translation="MAERDAPQAGPVGRLFRAGFHALSALRGARAFHPNGLLLKGELHA
                     LRRDEMALPQEPVTVIVRMSKGAGLPGRLPDALGLAVRIPAADGGPWDLTLTTSAGRVL
                     PRPARSWTAGRYTSLLPYRTNGELVWLSARAETPRHAEASLDALSRLVKEGPVTYLVET
                     VRANGHRNPCATLTLHEVDEDASRPAFDPMLNAPPGWELRPRWLTGLRERAYEGSREGR
                     "
     gene            complement(18813..20120)
                     /locus_tag="AORI_RS61630"
                     /old_locus_tag="AORI_4136"
     CDS             complement(18813..20120)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635685.1"
                     /locus_tag="AORI_RS61630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4136"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_016334473.1"
                     /sec_met_domain="Aldedh (E-value: 1e-81, bitscore: 273.7,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSSDASAVVEELRALFRSGVTKPVEWRRTQLTGLRKLLSEQADV
                     FLKALYADLRKNTAEAKRAEIALVRNEIDHTLENLDSWLSPEPAGLPYPLRPADGRVVR
                     EPLGVALIIGPWNYPLQLVLAPLVGALAAGNCAVVKPSELSPNTSAAIAEHLPNYVEGV
                     RVVEGAIPETTALLEQKFDTIFYTGNGTVGRIVMAAAAKHLTPVTLELGGKSPAIVEPG
                     ADLAVTAQRLAYGKFANAGQTCVAPDYVLAIGDTGPKLAEHLAETVKAMFGDDPATSEA
                     YGRIISTRHHDRLTALLDNGTVVVGGQADREEKYIAPTVLTDVSPDAPVMRDEIFGPIL
                     PIIDVPDVDAALAFVNERDKPLALYAFTESEETKRRIETETSSGGLVFGAAIIHLAAPE
                     LPFGGVGESGMGRYHGRYSIENFSHVKAVLDKPLAG"
     gene            complement(20326..22659)
                     /locus_tag="AORI_RS61635"
                     /old_locus_tag="AORI_4137"
     CDS             complement(20326..22659)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334474.1"
                     /locus_tag="AORI_RS61635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_4137"
                     /product="chitobiase/beta-hexosaminidase C-terminal
                     domain-containing protein"
                     /protein_id="WP_016334474.1"
                     /transl_table=11
                     /translation="MNRIFVQPKRRKGVRGALALGLSALLIAAGIGGATAAAADYSQSA
                     ASLNATQAQFSFTPATPARYVDIHYTGVPGVGQQNVRMTDNGGTWRHTIGSLSAGTVLD
                     YWFTYEKNGPQYDTPHFTYTHGGSGTTVASPTFDPPGGSYPSARSVTLSSATAGATIRY
                     TVDGSTPTASSTVYTGPITVSASSTISAIALKAGSANSPVSSAAYTIGSAQGTCPAQAE
                     VPDFGPNVRIFDPGMSAASIQSRLDADFNAQKDTLTAQFTERRYAHLFKPGVYNGIHDN
                     VGYYTSVAGLGQNPGDVVINGDVTVDAFNESDKGVALQNFWRSAENLAVVPSSGSTRWA
                     VAQAAPFRRMDIRGGLQLYPASYGFASGGYTADTKVSGQAASISQQQWYTRDSSYGSWD
                     GGVWNMVFSGTSGAPANTFPNPPETTLGTTPVSRDVPYLYLDGSGKYRVFLPSLRTNAS
                     GPSWANGGTQGSSLPMSQFYVVKAGDTASSINTALSQGCNLFFTPGVYHLNQTLNVTRA
                     NTVVLGVGYPTLVPDNGVDAMKVADVDGVRLKGLLFDAGTTNSQSLLTVGQAGSTANHA
                     ANPTTLQDVFFRIGGQIAGKATNSLIVNSRDTIIDHIWAWRADHGNAGTYGWTINTGDT
                     GVVVNGDNVLATGLFVEHYQKYQVIWNGQNGRTIFFQNEIPYDVPDQAGWKSPNGLNGY
                     AAYKVGDNVTTHEAWGLGSYCFFNDNPSVNLYHAFEVPNRSGVRFHNLVTVSLNYKGTI
                     THVINDAGAVTPPDTRPSNLVSYP"
     misc_feature    complement(22766..22781)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.44"
                     /tool="antismash"
ORIGIN
        1 ccagaacaag gaggaactga ccaccctcgg cgcctatcgg caacggtacg cggagtacaa
       61 gatggacgcc gatctccagg ccgcgcacgc cgtcgccccc tggctggtcg taccggacga
      121 tcacgaggtc gagaacaact acgccgcggg caagcgggac aacgacaagc catctctgcc
      181 ggacggatgg gccaagcgcc gcgaggccgc ctacaaggcc tactacgaga acatgccgct
      241 gcggggcggg gcgaaaccga acggggacaa gatccagctg taccggcggg tccgctgggg
      301 caggctcgcg accttccaca tgctcgacac ccggcagtac cggagcgatc aggcttgtgg
      361 cgacggctgg aagtactgcc ccgaggccgg tgatccgtcg cggagcctgc ccggcatggc
      421 gcaggagaac tggctgctgg acggtttctc acagcggcaa ggcacctggg acgtgatcgg
      481 ccagcaggtg ttcttcgcgc ggcgggcgga ccagaacggc gcgtcgggaa tggacggctg
      541 ggacggttat ccggcttccc gtgaccgtat ccagaagggc tgggtccagc gcggcgtccg
      601 caacccggtg gtgctcaccg gtgacgtgca ccgcgcctgg gcgaacgatc tcaaggcgga
      661 ctacaccaat ccgggctctc cggtggtcgg cacggaactg gtcaccagtt ccgtctcctc
      721 cggcggcaac ggcgcggaca ccacgggggt tccggaccag gcgggcaacc cgcacctgaa
      781 gttctattcc cagcaccgcg gctacgtgcg ggcgaaggtg agccagacca agatggacgt
      841 cgatttccgc gccgtcaaga aggtcaccgt acgcggcgag ccggtgacga cattgaggtc
      901 gtacgtcatc gaagaaggcc gtccgggttt gcaggccccg tgaccggtgt ccggggcccg
      961 gccgcgcatc tctcgcgacc gggccccggg cgctcagcct tcggccagga gcgcgaggcc
     1021 gagcggggtg atcgaatgca gcacggactg cccggcctga cggctggtga ccagaccggc
     1081 ggcgcgcagg gtggcggcct gctggctcgc cgtcgggagg ctggtcttcg tccgggaagc
     1141 cacttcggtg gtggtgccgg gagactcccc gatcgcctcg aggaccctgg cccgtgtccg
     1201 gccgagcagc gacgtcagcg gccggtgcgc cgctccgttc gccgaccagc ccaccttgtg
     1261 ctcgatcggg tacacgaggg tcggttccag ctcaccggcc aagaacgtcg tgggcagccc
     1321 ccagcagaag aaggacggcg tgagacacag ccctcgcccg ttcaggcgca gttcgtgctc
     1381 gaccggatag tccagctcca ggacggggta ggtccaccgc gccgtgggat gcacctcggc
     1441 gagcagggcc tcgcatccct cttcggtcat cgtcttgacc tgtctggcgc gtacctgctc
     1501 gacccggccg cacacccgca cccagtacgg ggcgaggcaa gccgtgtagt accgctcgac
     1561 cgagtccgcg agttgggtga gcgtctccgg cctgccctcg gcgagaccgg tggtccagga
     1621 cgggagccgc cggctcccgg cgagtacggt gagatcggtc cgaagacgct tcttcggggt
     1681 ccggcgcagc gcctcgagcc cctccgccag cgacaggttc cgcagggtcg gagtgaggaa
     1741 atcgaccgcg tagccggatt gcgaggcgag gtcggcaagc agccgggtgg tgacgtgtgc
     1801 cgcctgtgcc accgatcttc gccattcttc gaagatgacc ccgccttcgc ggcctcgcag
     1861 ccggtacatg ctgagcagga tctcccacat cggctgcggt gccgcactga tccgggtcct
     1921 ggcgaggtct tcgggagtga aatgaattct cagcacggcc gtctcccacg agaaccgcac
     1981 ttccgttgat ccgaaacgag cacgaacgac aagacatccc ccctggaatg aatccccctt
     2041 gcgacgcccg atgttagggg atccgctgcg tgccccgaca ctgtcgcggc cggaaatacc
     2101 gcgcaggacc ggcttccacc taccaccagg gttgacccgg cgaacacccc tttggggtag
     2161 gcgaaaacct ttgcctcgcc cggccggggt ctccgatgct ggggccatgc gaaccacagc
     2221 cgcgagcgtc ctcgccgccg tattggtcct ttgtggactc ctccagccgg tttcccggct
     2281 cgcccacgcg gaaccggatc tccacgccgc cgggcatccc accgccgact tgaaactgac
     2341 cagggacgac atcctcacca gagcgaagag ctggctcgac gagcgagtgc cctacagcca
     2401 ggaagccaag cacaccaacc agtacggcac ctaccggcag gactgctccg gctacgtgtc
     2461 gatggcctgg ggcctgaaga ccgctcgctg gacgggcgac atcatgcagg tcgccacccg
     2521 gatcgacaag aagaacctct tgccgggtga cagcctgtgg gtgcattcca gtgcccacca
     2581 gcacatggca ctgttcatcc ggtgggcgga caccgcgaag acccaggcgg tggtgtggga
     2641 ggagtaccgc tccgggaccg tcgcgtcaca gcgcacctgg tcggctgacc ggacggcggg
     2701 attcaccgcg atccggtacc gcaacgtcgt cgaaggcgac gccaagacct gcgcggcggt
     2761 gagcctcgac cacccgcgct atcccgagat cgccgcggcc gcgaccgggg ccctggtcaa
     2821 ggcggcgcag tgcctgctca ccgcagcggg attccccacc ggggcgaacg gtcccacggg
     2881 caccttcgac acgacgaccg ccgacgctac gaaacagttc caggcgagtc tgggcctggc
     2941 ggcgctcggc aaggtggact cgcacacgtg gacggcgttg ctggcgaggg ggacgacgcc
     3001 acagctccag gacggagcct ccggagacgc ggtgctgcgt cttcagcgtg cgctgaacgc
     3061 cgccctcgac gcgggcctcg aactcgacgg ccggttcggc gcgaacacca cggccgcggt
     3121 gaagcggtat cagagcgcgc acgggctcac ctcggacgga atcgccgggc cgaagacctg
     3181 ggctgcgttg caggcgggca aatgagaaat ccactgtgga cggagaagag gaatgcgatg
     3241 cgggtgaaga cggcggcgct gggaatggcc atgatggtcg ccttcggcct cgcgacggcg
     3301 aaccaggcga cggcggccac ggccgctgat ccgaccggtg ccgagttgag tgcggtggtg
     3361 gcgacctgcg cgcagcaggt gtccgccggg aaatacgccg aacgcagcgg cggtacccgc
     3421 acggttccgg tctgcgcgac cggcggggcg gtgcactggc ggtccgggat gacgatcgac
     3481 tgcgacgggc agcgcaccga gaagtgcaac gcttcgaccg atccctcttg gcaggggcag
     3541 accgcgtggg cgcagccgga cggcaagccg ctcaacgccg agaaactgcc ttacatcgtg
     3601 gttcccggga tcagctcgac gtggagttac gccggctccg gcatcaccgg tgccacggtc
     3661 gccgcggtcg tctatcaggg caaggtcgcc tacgccgtcg taggcgacgt cggcccgacg
     3721 ggggcgatcg gcgaaggctc ctacgcgctg gccaaagcgc tcggcatcaa ccccgacccg
     3781 cgttcgggcg gggtgtccgg caaggtcgtc gactacatcg tcttccccgg agtcaaggcc
     3841 tcgcccatcc acgacgccgc cgacgcggcc accgaaggca ggcgggccgc ggcggagctg
     3901 gtatcccgtt cccgtggctg cgcgaacgcc ggtgtcgacg gcccctatcc gcggctcgac
     3961 gccggcgtga cccgccccga ggtgaaggcg gcgcaatgcc tgctccgtgc agccggacag
     4021 gacacggggg ccggtgatcc cagcggcgtc ctggatgcgg cgacggtgtc cgcggtgaag
     4081 cggttccagg cgcaggtggg gctcgcggag acgggctcgg tggactcgca cacctggacg
     4141 gcgctgctgg cccgcggcgc cacgccgcag cttcaggacg gctcgtccgg tgaagccgtt
     4201 ttccggctgc aacggtcgct caacgccgcc atctcggcga agctgaccgt cgacggcaag
     4261 ttcggcgcca agaccaccgc ggccgtcaag ggctaccaaa cctcgcgggg actcaatgcc
     4321 gacgggatcg ccggtgcgaa cacctggcgg gccctgcagg ccggacggtg aagtgtcctg
     4381 aggcttccgg gctcttcgcc ggaagcctca ggcgcccggc gtgacgagac cggattcgta
     4441 ggccagcgcg acgatctgcg cgcggctgga gagtccgagt ttcgtcatcg cgcggttcac
     4501 gtgcgtcttc accgtggatt cgctcaccac cagctcgccg gcgatgccgc cgttggtcat
     4561 gccctttccg accaggcgga gcacctcggt ctcccgggcg gtgaggcagt ccagttccgg
     4621 tccgggcgcg ccggtggggc cgcccggccg gttcgcgtag gcctcgatca gccgccgcat
     4681 gaccgagggc gcgaacaact gctcccccgc cgcgatcgtg tggatcgcgg cgaccagccg
     4741 ttccgcccgg acgtccttga acaggaagcc cgaagccccc gcccgcaagg ccgcgtacac
     4801 gtactcgtcc agatcgaacg tcgtcagcac cagcacacgc gtcggccggt cgcgttccgc
     4861 ggcgaggatg cgctcggtcg cgaccacacc gttcgtgccc ggcatccgga tgtccatcaa
     4921 gacgacgtcg ggccgcagcc gcgccgccag gtccaccgcc tcctgtccgt cggcggcctc
     4981 accgacgacg gtgatgccgg gcgcggcccg caacagcgcg acgaacccgg cccggaccag
     5041 atcctggtcg tcgacgacca gcacctcgat catgaaccga ctccccctgc cgccagcggg
     5101 agcacgagcg tcaccacgaa acccccttcc gcgctcgcgc ccgccaggag tgttccccca
     5161 tacagttcgg cgcgctcacg catgccgatc atgccgtgtc cggcgccctc gtggaaccgt
     5221 tcggagcggc cgtcgtcggc gatccggacc gtcacgtcct ccgccccgta cgtcagcgac
     5281 acccacgccc tggccggacg ggcatgtttg acgacgttgg tcaaggcctc ctgcacgacg
     5341 cgataaacgc agagtcccac cccgtccggc agcgagcgaa ccgtcccccg cacggaaacc
     5401 tcgacgtgca cccccgcggc accgaccctc gccgccagtt ccttcaaccc ctccagtcca
     5461 ggggccggta cgtaagtgtc gtcgtcttcg ccggaccgca gcaccgtcag catgcgccgc
     5521 agttcgtcca ggccctcact gccggtgcgg ccgatgacgt ccagcgccgt ccggctggcc
     5581 gccggatccg actcgaacac gtaccgcgcc atctccgcct gcaccgcgat gaccgacatg
     5641 tggtgggcca cgacgtcgtg cagctcacgc gcggtgcgga cccgttcctc cgtcacggcc
     5701 cgccgcgccc tgtcctcctg ttcgcggcgc agttgctcgg tcagcatccg cagctggccg
     5761 ttgcgctggg ccagccgccc cgcgttcgcg ccgaaacccc atgccacgcc ggtcaggagc
     5821 acgctctgga acaccgccgt ccacaccgag ccgatcagct gcgcatgaca ggccgaatag
     5881 gtctcgcccg ccagcgtggc cgccgcgcac agcgccgtca ccggaagaga ccggtacgcg
     5941 gcgacggtgt acagaccgag caacagcgcc agcgcgctga cgcccggcca gtaccccggg
     6001 agcaggtagc cggcccatcc ggccagcacg agaacgaaaa ccgtcagcgg cgcacggcgc
     6061 cgaaccgcga gtggtgcgtt gaccagcaca ctcagcagga cgccggtcga gtcgaacggc
     6121 cggaagccgg ggaggccgac agcgaagccc gcctcgatgg tgaacgcgat catgaacacc
     6181 gcgaggaccg cgtcacccac ttcgagagcg ttccttctca gccaggtcgg tgggcgcaca
     6241 cgaaacgata gccgtcgaag ccatcaccgc gcgtccggcg ccgggactac ctccctaccg
     6301 cacaggttga cgtccggacc gccgtcacac cggccaagtt gcgaggcgtg gacaaaccga
     6361 tccggtatcg gtggttcgat tctcggcgat ctcacacttc ccgccagggc cggtggaaaa
     6421 acggcagttt tacgctcatt ccgcagctgc tttcccgcta gtttccgccc cgtagggacc
     6481 gggggaactg gtcatcgaat cgtcgagatc ggagatgacc ggcgtgaaag ccatcgtcct
     6541 cggccgcacg gcaggggcgg cactgctcct gttcgcggca gcatgcagtt ctccgacggc
     6601 tcccccgccc agcacgcccc cctcgtctcc ggcgaccacc gcacccgcga gcacgacacc
     6661 gactgtcgat ctttcgtcgc tgcgtcaagg cgcggtcccg gcgaagtatc ccgagccgga
     6721 tatgagcaag ttgcctccca agcccgcgga ttccgcaccg ctgcgggagc ggatcgcctg
     6781 ggaagcactg caaaaagtga ccagattcgc gcatcgactc gaccccgcgg cgcgctcgtc
     6841 ctgccccgcg ttcgaccccg gccgcaccac cacggtgacc tgcacggtca cctatctcgg
     6901 cgagggttac gactacgttc tgcgcgacat caaattccag ggcaccggac tgaccaacgg
     6961 ccgcaccgaa caagggaccg tctcctacaa ggcggacctc accgccgggc cgatcatccg
     7021 cgaccaggtc gagtcggtgc tgcgctacca gaacagcacc gagtacgcgg cctgtgacat
     7081 gcgcgagcac gtgcgcttcg gattcgactc cacccggcga cggccgtccg ggtcgtcagt
     7141 cgtcggcgag tggatctacg ttcccggcat ctcgtgccgc tacctcgatt ccaaggcccg
     7201 agcggtcaaa gccattccct tggagctcta cgactggggc gcgcccatcc atccgtaaca
     7261 gcggttcggc ggctgaggcg ggtcgccgtc atcggccgcg gtgaagggcg agtaaccgat
     7321 ctcgacgccg gtcgaccgac aggtcggaga acacgagcga gctggtgtgg ccgtcggctt
     7381 cgatcatcgc ctcatggaac ggccgcccca gccgggcgga ccacgcgtcg gtgtccgctg
     7441 tgccgggccg cagcttcgcc ccggggtaga ggctgtccac aggaacgctg ttcgggcgaa
     7501 aatgcccgct ttggccactt cgcgcggggg tcgtgagtga tttgggtgat tctattacgg
     7561 cacgggttcc ggaccggctt gcggctcacc cggcgtacag tgtccacaag ggacaatgcg
     7621 cgccaatggc gcgcccggtt gatgtcgtga tgtccggttc tcgcaccccc acgcaaagcg
     7681 cgcaaaccgg acacgaatga cgaggccgcc atcctttgcg gacagtcgca ggtgcggctg
     7741 gtcccgcagg cgagccctcg gcgggcaaca cgccacgttt gccctacccc ccaataacgc
     7801 gcctcgggcg tcaccgcgga agtcgccgac gcacggacac agtgcttgaa gcgataccac
     7861 aggaactccc ggacccgtga aagaggagca cctggtcgac atcccacaag aggcatcatc
     7921 tcgcgcgacg agcctggatg aggacgcgct ccccctggcc tcgtcacccg tatcggtgat
     7981 tctcgccgac tcaccattcg tggcaagtgg atcaccggtt cgtgtcaccc cgccgcccac
     8041 ttgccgtagc ggaggctcag cgtccacatc gacccgccgc aaccccgcta cgcacggtgt
     8101 cgccgcctcc aaaacccacc cctggcgcaa aacacgaaag acttacgtgt ttatcgtagg
     8161 aagattcacg acccgccgaa aacccgggaa atcgtttttt gacagggcgc caacgtggtg
     8221 aaaatcttcg atcgctcctc gcgagagcac aaccgaacac gaaatccgaa caaggagccc
     8281 ctcaatgcag atgttcaccc agcacgtgca ccacggtcac gacctcattt cgggtctgct
     8341 cgcgcacctg gcccacgtgc tcggatggct ggtctgacgc tctaagcaca gggattgacg
     8401 ggggccaatc tgttggcgcg ggtcggcccc tcgtgtttgc gacccggtaa aggggcacgt
     8461 tcgtgtccct ttaccgggtt ccggttttta acccctgatt ggaataccgc taaagcgcga
     8521 accccagttc ccggccccgc gccacgagtt cttccctggc cgagggatgc gcgacctggc
     8581 cgacgatctg ccgcgcctgc tcgctcgcgt cgttgcccca gatcgtcgcg acaccgtgct
     8641 cactgaccac gaaactgtgc tggaacgagg tcaccggacc ggtcagccgg ggcacgaccg
     8701 tcgaaacgtc ggccttcgga tgccacgacg gcagcgcgat aatcgcccgg ccgccgggtg
     8761 aatgcaacgc cccgaccacg aagtcggtct gcccgccgaa tccggaatag atggcccctc
     8821 tcacgcggct cgcgttggcc tgtgcgtaca ggtcgacctc gagggcgctg ttcaccgaca
     8881 ccagaccgcg ctgccgggcg atcacggcgg gatcgttcgt cttttccgtg cgcagcaggc
     8941 ggattcgcgg attgcggtcg agccagcggt acaggtccgc actgccgaac acgaacgacg
     9001 cggtcaccgg ttcggccgga tcgagggccc cggcgcggtc gagcgcgagc acaccgtcgc
     9061 tgaacatctc cgaccagatc gcgagcccac gccgtccggt caccgccgcc agggtcgcgt
     9121 cggggatccc gccgatgccc agctgcaggg tcgcgccgtc ctcgaccagc ccggccaccc
     9181 gctcaccgat ggtccgcgcc gtgtccccca ccggccgcgg gaccggcgac agcagcggtt
     9241 cctccacctc gatcccgtag tcgatctcgt cgaccggcac gagaccgtcg ccgtaggtga
     9301 acggcatctc gggattgagc tgcgcgatga ccaggccgcc acgggcccgc accgcctcga
     9361 tggccgcggg caggatgttc acctccgtac ccagcgacac cacgccgccc accggggccg
     9421 aggtgtgcag caggacgacg tccggcggca gcgagtgctt gagcagctgc ggcaccagcg
     9481 acagccggga cgggaagtac cgcagcccgg aacggccgcg catccccgcg cccacgaacg
     9541 gcgtctccag cagcacaccc tcgcgatccg gcatgcccgc ctgagcgttc aacgcgaaca
     9601 ggcggtactc cgccagcgcc gcgtccagca ccttcagcgc ccgcatcggc gtggcgaaat
     9661 tcccgctcac caccactcgc gggcacgaag cgggcacgcc cgcgagaacg gaaccgagct
     9721 ggctttccga caagacgcgc atgagccgat catgcccgag gagccccttg ccggcgcggg
     9781 ccggaccccc agggaaaccg gcccgcgccc ggcacctcct caccatggtg cgaccggggc
     9841 cggtgcccgc acatgggtac cgggacccca tattccggtg cggcaccgga cggccaccgt
     9901 ccgtgcccgg cggtcactct ccggacatct tcgtgcgtgc gctgaatgtg ggggtgccgc
     9961 ccccatgtgc gtgccgggcc gagctgacag cattaccgcc gtgacgcccc aaccatcggc
    10021 gacgtccctg ccgccgaggt ggtgggagca cggccggacc ccgcgcgagc ggtcagcgga
    10081 caagcccctc tgggccgact tcgccgaaca cgccatcacc acgcttctgc cggagcgccc
    10141 cccagtcggt gactggcgtg cggcgttcgc cggggtcttc aggtctctcg tcgacgccgc
    10201 ctcgcgcgac gcggtcccgg atgatctccc tggcgccgac gtcgatgcgc ttcgtcaggg
    10261 tttcgcggcc aatctagatc agcacctgct caacctttcg gtccgcacgc tggtcctcga
    10321 actccaccgt gcccgcaagg ccggaaccct ccagggcgag acgcctgaag agcgcttctc
    10381 ggatttcgtg cgcagtcaat cgacgccggc cgggctcatc cggttgttcg gcgagtatcc
    10441 ggtgctggcc aggctcctcg cccaggcctg cctgtacgcc gccgaagccc acgccgaaac
    10501 gctcgcccgg ttctcggccg atgcggccct gctgccctgc tcggtcgtcg acggcgcact
    10561 cggcacgctc gtcgaggtcg cgggcggatt cggtgactcg cacgcctgcg gacgttcggt
    10621 caaactgctt cgcttctcca gtggcgccaa ggtgatctac aaaccccgcc cgctggtcct
    10681 gcacgagcgt ttcacagacg tcgtcgaaca gctcaacaag cggctgccgg gccttgaact
    10741 gcggaccgcc gacgcgttgc cgcgtgacgg ctacggctgg ctccggttcg tcgaacaccg
    10801 gccgtgcgcc gacctcggcg acgtcgaccg cttctaccgc aggcagggca tcctcctggc
    10861 gctcctgcac gcgctcgacg ccaccgacgt ccactacgag aacgtcatag cctgcggcga
    10921 ccagccggtg ctgatcgaca tcgagaccct gttccagccg tcgccgcccg ttccgccgga
    10981 gggcgacccc gcggcggcga tgctggcgcg ttcggtgcag cgcacgctgc tgctccccca
    11041 gctcttcgcc ggcgagcacg gtgccgtcga catctccggg ctcgccggcc gcggcggcaa
    11101 gctgcccacc gaccgggtcg attgggccga cgcggggacc gaccggatgc gcctggtccg
    11161 ggttcccggg gaactcgccg gaagcaacaa cctgccgcgt ctcgacggcc gcgacgtcgc
    11221 tcccgccgaa cacagcgcgg cgctgctggc cgggttccgg ctcggctacg acgcgatctc
    11281 ctccgggcgg gaagagctca ccgagctcct ccggcgctgt gccgaggatc ccatccgggt
    11341 gctcatccgg ccgacgaact tctactcccg cctgctggac gagaccaccc atcccgacct
    11401 gcttcgcgac gccgccgacc gcgaccgcgc gttcgacctg ctcgaagagg actcggtgcg
    11461 ggaggagaag ctgctccggc tggtgccgca cgagcgggac gatctgtggg cgggcgacgt
    11521 gcctatgttc acctcgaacc ccggctcgac gtcgctgctg gattcgcgtg gcgacagcgt
    11581 cgaaggggtc gtcgaccggc cgtcgctcga caccgtgctg gcgaaggtcg ccgacatgga
    11641 tccgctcgat cagcgggacc aggagtggct gatcaccgcc accctcgcca tcagcacggc
    11701 ggccgacggc caccacagca acggcgagac cgcggagacg gcggtgccga atcaagcgcc
    11761 cgacgcggaa agactgctgg tcaccgcgtg cgggatcgcc gaccagatcg tcgccaacgc
    11821 cttctccgac gagcaccgct ccaactggct cggcatcgag ctcgtcgacg accggtactg
    11881 gaccgtcctc ccgatgggcg cggggctcgg cgagggctac tgcggtgtgg cgttgttcct
    11941 cgcccagctc gcggagctga ccgggatcgc gcgctaccgc gatctggccg cgtacgccat
    12001 cagcccgctc cccggccttt tcgccaccct ccgcgccgac cgcgaattgg ccgccaccgc
    12061 cggctgcggc gggctgctcg ggctcggcgg cgtcgcgtac acgatcgccc ggctcagcac
    12121 gctggtcggg cttcccgcgg gcgatctcat cgagcaggcc gtcgacctga tgcccgaggc
    12181 caccgccgaa acaccctccg ggttcacgac cggactcgcg ggcggcgtcg cctcgatgcg
    12241 ttcggtgtat gtccaaacag gactggagac ggcgctggcc cgggcggacc gctacgcgac
    12301 acagctgctc gagcgcgaac gtccagcgga gaagtccttc gcccgtggtt cggccgggat
    12361 cgactgggtc ctgcgggcac acgaacgtcc cggcgaagaa ccgcccggaa aggcggacga
    12421 tcgggcggaa agcaccggcg ggtggtgtga cggcctcgcg ggcgacgccc tcggaacggc
    12481 cgcgcacctg cccgatcccg agcacgccag ggatctggac cggacgatca gacggctgac
    12541 cgaccgggca ccgctgaagg atctcagcct ctgccacggt gagtccggag tgctggacgt
    12601 gttgtgcgtg ctggcggaga acgggcacac tggcgccgcg gccgcggcac gccgccggac
    12661 cggtcatctg ctcgccgcca tcgatcagcg cggtgcccgc tgcggcacac ccggcgcggt
    12721 tccctcgcca gggctgctga gcggcctggc ggggatcggc tacggcctgc tgcggctggg
    12781 attcggcgac cgggtcccct ccgcgctcct gctccgcccc gaccggccgc accccgcggc
    12841 caccgttttt ccgccggtaa accgagtatg aggagaagaa ccacatgtac gaaagagatc
    12901 tgcccgccac cgaagacgtc ctcggcgccg tgaacctgcc gcgtgccctc gaggtcggct
    12961 cgcgcaacca cgcgctggcg ggcagcaagc cgcggctgag cgccaacccg ctcgccaccc
    13021 tgtccacgga caccggttcg ccgtccgtcg tcagcgtctt caccggcggc tggatctgag
    13081 tagagctcac gaaggcgggt tcgcgccgcc cgccttcgtg atcgactttt ggccgtgaca
    13141 gcggaatccg ctcgctatag tcacggcggt gggtatccgt tcgtcgcgga tgatcggccg
    13201 cgacgccgaa ctggccgagc tctccggagc tctcgatcgc gccatcgcgg gtcgcggcgg
    13261 cgcgatcttt ctcgtgggcg agggcggcgt cggcaaatcc cggctcgcca tcgaagccgc
    13321 ctcgcgggcg gtcgccgccg acgtcccggt gctgcagggc agggccagtt cgatcggccc
    13381 gctcgtcccg ttccggccgc tcacccaggc actgttgtcg cattttcgcg gcggcggccc
    13441 gccggaggcg accgaactcg acccgttcat ccccgtgctc gcccagctca tcccggattg
    13501 gagccgagga gaccggcctc gcgagtccgg ctccctgatg gtgctcgccg aagcggtgtt
    13561 ccggctgctg gccgtcacca gccgcgaccg cggcgcactg ctggtcctcg acgatctcca
    13621 ggacgccgac gccgagacgc tgttcatcct cgaatacctc gtcgacaacc tgcccgcggc
    13681 gcagaccctc ttcgtcggca cgctccgcag cgaaccctcc gacgcgctgc gcctggcgac
    13741 ctccggagcg caacggatga gctgcgccgt cgtcgaactc ggcaggctcg gcctcgccga
    13801 cacccacgcg ctcgccgccg cctgtctcga gaccgagccg ggccggctgc cgtcggccgc
    13861 gacggaactg ttgtggcgca acagcgccgg tcttccgttc atcgtcgagg aactgctcca
    13921 cggcatggtg aacgacggcc tgctggtcga gggccgcgac ggctggcgcg tcatcggtga
    13981 actccgcgcc cgcgtccccg ccgcgctggt caccagtatc ggcgtccgga tggagcaact
    14041 cggcgagcag gcgggtgagc tgctttcggt cgcggcgatc atcggccgtc gcttcccctt
    14101 gacggtggtg caggcggtca ccgggaccaa cgaccggacg ctgcacaatc acctcggcgc
    14161 cgcggtctcg gcgaacctgg tgaccaccga cgagatgaca cccggctggt acgccttccg
    14221 tcatccgctg accgcggaag cgttgctggc gcgtcagtca ccggcgcgga aggcggaact
    14281 cgcccgtcaa accgccgacg cggtcgagga gctgtacccg gggctgccgg gcgacctgtg
    14341 cgcgctcgtg gcgtcgctcc ggctgaccgc cctggacgag cgggcggcgg gccggttgtt
    14401 cgcggagacc ggccgtcgcg cgctcgacgc cggcgccgcg gactccgcgg tcacgatgct
    14461 cacgaaggcc ctcgacctgc tcgccggtgc cgacgcgggt gatcgggccg aggtgctgga
    14521 gacgctggtc cacgcgctcg ggcagaccgg tcagttcgac cgcgccgtcg aactttccgc
    14581 cgcgttcggc gagatcggca cgctcgaacg ggccgcgaaa ctgcgcaccc agctggcctg
    14641 ggcggcctac atcgcgggac ggcacgatga atgcctcggc cagatcgaac gcgcccgcgc
    14701 tcccctgggg tcggcgatct cacccgctca gcaggccgcg ctcgatgccg tcgaggcgaa
    14761 cctctggctc gacgtccccg gccggaccgg gacggccgag cggctcgcgc gtcaggcatg
    14821 gaaggtggcc gaggcgaccg agcagccgtt cgtcgtctgc caggcgttgc aggtgctcgg
    14881 gatgctcgcg ctgtcccggg acctcagtga atccgagcac tacatgcaac tcgcgcggcg
    14941 gaccgccgag gacaaccatc tgcatcacct ccgcacccag gcgctggtcc ggctcggcgg
    15001 acatcgcgta ctgatgaacg gcgacgagca gactctgctg ctcgcccgtg ccgacgccca
    15061 gcggaccggg tcgatcacgc tgcattgcgc ggtcgattcc gtgcgcacca tgcacgcgat
    15121 cctgcgctgc gacttcggca ccgcgcacac gctgctcgcc gagaacctcg ccgtgctcgg
    15181 caggctccgg ttgaccgcgt tgctgcagta cgcgcatatg accagggcga tgtcggccgg
    15241 gcaccgggcg gaccgtcccg cgatggagca ggcactcgac gacttccgcg aaagcggcgg
    15301 cgagaacgcg caggagatgg tgctcagcat cgggctggca cgggtcttct gttcgctgct
    15361 cgaagaggac ttcgaccggg cccgccgcga actcggccag gtcatcgagc tggaggaccg
    15421 gcggccgagc cggttccacc tcgccggcca gcacgggctc aggacgctgg tcgacaccct
    15481 cggcggcgcg ccctgcccgg acggcggatc cgcggtgagc gggatgcgct ggaaccggca
    15541 gttcgtcgaa ttcgcgcagg ccgtcgagca cggcagacgc ggcgacgcgg ccgaagccga
    15601 acgagcggtg gcctccgcgc tggagacgtc ggcgccctat cccttggccc gccacctcgg
    15661 gctccggctg atcgccgaac cggccgccgc cgatggctgg ggcgatccgg ccggctggct
    15721 caaggaggct gaagagtact tccacggcag ggacatccag gccgtggcgg ccgcctgccg
    15781 gaccctgctc cgcaagctcg gagcccccgt gcggcagcgg cgctccgggg tcgaccgggt
    15841 tcccggcgac ctgcgcgcgg ccggggtcac cgtgcgcgaa tacgaggtgc tcgtgctgct
    15901 cgccgagcgg atggggaaca aggacatcgg cgcccgcctg cacatctcgc cccggacggt
    15961 cgagaagcat gtcgcgagcc tgctcgccaa gaccgggctc gccgaccgtg ccgccctcgc
    16021 cgaacacgcc gccggaccgc gacctggcat gctgtgagcc atgagcgacc tgatcgtgta
    16081 cggcgccggc tggtgccccg acgtcaaacg cagccgggcc ctgctggact cgaagggcgt
    16141 cgagtacgcc tacatcgacg tcgaagcgga ctccggcgcg gaggagacgg tgcgcgcgct
    16201 gcagaacggt gagcggcgga tcccgaccat cgtctggccg gacggcaccc acctggtcga
    16261 gccgagcgac gacgagctca ccgcgcacct gaaccggtga ccctcccgga cgtcccggtc
    16321 ggcacgaggg tcgtcgtgcg gtaccggatc gaaggcgggt tcaccgacgc tctcggctac
    16381 ctgcgctccc gcgacgagac cgaatgcacg gtggagacca agcgcggcct cgcgacgatc
    16441 cggctggcgg acatcgtcct ggcgaagacg gtcccgccgc ctccggctcc gcgcagtcct
    16501 cgtgaggggt gaaccgcggc gtgcgtggcc gatcggtcca ggtggtcgtg agtggcgttt
    16561 cgggttagaa cccgaaacgc cactcacgag ccccatcgcg aaccggacta gctcttctgt
    16621 gacttcgtgg ccttcttctt cgcgtccttc gccttcccct tgatcgtccc gacggcgtcc
    16681 tgcagcggcg cgtaggtgcc gtacagcgcg ggatccggtt tcggagcggt acccggaccg
    16741 ccgagcgcct ccggttccat caggtactcg atcccgtctt cgccgaagct ccagccgccc
    16801 ttcgcgccgt ccggcccgtc ggacagatgc cacacggtgt tgttgtggtc ctggttctcc
    16861 tcgtcgaaca acgccgtcgg cgcgatgtcg ctttccaggc cgtcggcctt gagctcctcg
    16921 atcgcggcga gccactgctt ctggtgcacc gtgtcgcggg cgaggttgaa ctgcaacatc
    16981 gccttcacgc ccgggtcgtc ggtcatgttg tacagccggg ccgtctgcaa gcggccctgc
    17041 gcctcggccg cggcgttcgc ccggaaatcg gccagcagat tgcccgacgc cacgacgtaa
    17101 cggccgttcc aggggtagcc ctggctgtcg ctcggcgtcg cgccgccgcc ggagatgatc
    17161 gcctgctggg gatccatccc gcccaggatc gccgcggtgg ccggatcctt cgccgcctcg
    17221 gcgaccgtgg tggcgggtgc cccttccagc agccgggcga ccatcgtcgc gagcatctcg
    17281 acgtgcccga tctcctcggt cgccgtgtcc atgatcaaat ccttgtactt gccctcgatc
    17341 cggcaattcc agccttggaa gaggtactgc atggtgacgg tcatttcacc gtaggcgccg
    17401 ccgatgagtt cctggagctt acgggcgtac aaggcgtccg gcttttccgg cttggcctcg
    17461 aactggagcg atttggtgtg acggaacact gattacctcc gattaatggg gaagaacggg
    17521 tcagcgcgag tcggctatcg gcgccttcga accggagagc ggaatgagcc cgagtgcgat
    17581 catcccgacg gcgagcccga ggtgcagcca gttgtcggcg ctgttgaccg gcacgaagtt
    17641 cgccgccgac ccgtggtcga tcagcagtcc gtacagccac agcacgaggt agaccacccc
    17701 gccgccgacg aggaacgcct tcgcaccgct caccgtccgg gccagcagaa tgcccgcgac
    17761 gccgaacgcc agatggacga tgttgtgcag gatcgaaacc tggaacacgc ccagcagcaa
    17821 cgcgccggac tcgtgcccgg caccgctcag ctgctcgtag ttcgtggtga tgccgggaat
    17881 gaagccgaga atgccgacga gcaggaagac cgcgcccacg gcgagggcga tgagctggcg
    17941 cggagcccgc cgaacggtgg ccggcgatgc agtcatgatt tcctccgatc caggtggaat
    18001 gagcttccgg aaggtcgagt acccgcgccg gagccggcca caccggggaa tcggcgattt
    18061 cgaattcgtg ggaattcccg tgtaatccgg tgcagccggg gtagtcggcg cgaagcaccc
    18121 acatgacaag gaggcggaaa tcgtggccga gcgcgacgca ccgcaggcag ggccggtcgg
    18181 caggcttttc cgggccggtt tccacgccct ctccgcgctc cgcggggcgc gggcgttcca
    18241 cccgaacggc ctactgctca aaggcgaact tcatgccttg aggcgcgacg agatggcact
    18301 tccgcaggag ccggtgaccg tcatcgtgcg aatgtccaaa ggggccggtc tcccggggcg
    18361 cctgccggac gcgctggggc tcgcggtccg gatccccgcc gcggacggtg gcccgtggga
    18421 cctcaccctg accacttccg ccggccgcgt gttgccgcgg ccggcgcgat cctggaccgc
    18481 cggccgctac acctcgttgc tgccctaccg cacgaacggc gaactggtct ggctgtcggc
    18541 ccgcgcggaa acaccgcggc acgccgaagc gtcgctggac gccctgagcc ggctggtgaa
    18601 ggaagggccg gtgacctatc tcgtcgaaac cgtccgcgcg aacgggcatc ggaatccctg
    18661 cgcgacgctg accctccatg aggtggacga agacgcctcg cgcccggcct tcgatccgat
    18721 gctgaacgct ccgcctggct gggagctgcg gccccgctgg ctcaccgggt tgcgcgagcg
    18781 cgcctacgag ggcagccgcg agggccgctg actcaacccg cgagcggctt gtccagcacc
    18841 gccttcacgt ggctgaagtt ctcgatcgag tagcgcccgt ggtagcggcc catcccgctc
    18901 tcccccacgc cgccgaacgg tagttccggc gccgcgagat ggatgatcgc cgcgccgaac
    18961 accagcccgc ccgacgaggt ctccgtctcg atcctgcgct tcgtttcctc cgattcggtg
    19021 aaggcgtaca gcgccaaagg cttgtcgcgt tcgttgacga acgccagcgc cgcgtcgacg
    19081 tcgggcacgt cgatgatcgg caggatcggg ccgaagatct cgtcccgcat caccggggcg
    19141 tccggcgaga catccgtcag cacggtcggc gcgatgtact tctcctcgcg gtcggcctga
    19201 ccgccgacga ccacggttcc gttgtccagc aaggcggtga gccggtcgtg gtgccgggtc
    19261 gagatgatgc ggccgtaggc ctcgctggtg gccgggtcgt cgccgaacat cgctttgacg
    19321 gtctcggcca ggtgctccgc cagcttcggg ccggtgtcgc cgatcgcgag gacgtagtcg
    19381 ggcgcgacgc aggtctggcc cgcgttggcg aacttgccgt acgccagccg ctgagcggtc
    19441 acggcgaggt ccgccccagg ctcgacgatc gccgggctct tccctcccag ctccagcgtg
    19501 accggcgtga gatgcttcgc cgccgcggcc atgacgatcc ggccgaccgt cccgttgccg
    19561 gtgtagaaga tggtgtcgaa cttttgctcc agcaacgccg tcgtttcggg gatcgcgcct
    19621 tcgacgacac ggacgccctc gacgtagttc ggcagatgct ccgcgatcgc ggccgaggtg
    19681 ttcggggaca gctcactcgg cttgacgacc gcgcagttgc ctgccgccag cgccccgacc
    19741 agcggcgcga gcaccagctg cagcgggtag ttccacggcc cgatgatcag cgcgaccccg
    19801 agcggctcac gtacgacgcg gccgtcggcc ggtcgcagcg ggtacggcag gccggcgggc
    19861 tccgggctca gccaggagtc gagattctcc agcgtgtggt cgatttcgtt ccgcacgagc
    19921 gcgatctccg cgcgcttcgc ctcggcggtg ttcttgcgca gatcggcgta gagcgccttg
    19981 aggaagacgt cggcctgctc ggacaggagc ttccgcaggc cggtgagctg cgttcgccgc
    20041 cactccaccg gcttcgtgac accggaacgg aagagggcgc gtagttcctc gacgacggcg
    20101 gaggcatcgc tgctggtcat ggattcgagc ctagtcatgg actacggcgg atgcccagcg
    20161 ttgggcggta tagagcgtta tacaagaagc cgaaggggct ttcccgcgtt gcatggcgct
    20221 gtcgtgcgtg ggctgaaggc tcccttcgtc gcattagatg cagcgaaagg agccttcagc
    20281 ccggctggat acgggtcgtg agtggcgaag cccttcagcc cggcgttacg ggtagctcac
    20341 caggttgctc ggccgcgtgt ccggcggcgt caccgccccg gcatcgttga tcacgtgggt
    20401 gatggtcccc ttgtagttca acgagacggt caccagattg tggaaccgga cgccggagcg
    20461 gttcggcacc tcgaacgcgt gatacaggtt caccgacggg ttgtcgttga agaagcagta
    20521 gctgcccagg ccccacgcct cgtgcgtggt cacgttgtcc cccaccttgt aggcggcgta
    20581 cccgttgagc ccgttgggac tcttccagcc cgcctggtcc gggacgtcgt acgggatctc
    20641 gttctggaag aagatcgtcc tgccgttctg gccgttccag atcacctggt acttctggta
    20701 gtgctcgacg aacagaccgg tcgccagcac gttgtcgccg ttgacgacca cgccggtgtc
    20761 gccggtgttg atcgtccagc cgtaggtgcc cgcgttgccg tggtcggccc gccaggccca
    20821 gatgtggtcg atgatcgtgt cacggctgtt gacgatcagg ctgttcgtcg ccttccccgc
    20881 gatctgaccg ccgatccgga agaacacgtc ctgcaaggtg gtcgggttcg ccgcgtggtt
    20941 cgcggtcgag cccgcctggc cgaccgtgag cagcgactgc gaattggtag ttccggcatc
    21001 gaacagcagg cccttcagcc ggacgccgtc cacatcggcg accttcatgg cgtcgacgcc
    21061 gttgtccggc accagcgtgg ggtagccgac accgagtacg acggtgttcg ccctggtcac
    21121 gttgagcgtc tggttcaggt gatagacgcc aggcgtgaag aacaggttgc agccctggga
    21181 aagggcggtg ttgatcgacg acgccgtgtc ccccgccttc acgacgtaga actggctcat
    21241 cggcagcgaa gagccctggg tgccgccgtt ggcccagctc ggcccggaag cgttggtgcg
    21301 caaggacggc aggaacacgc ggtatttacc ggagccgtcg aggtagagat acgggacgtc
    21361 gcgggacacc ggtgtggtgc cgagcgtcgt ctccggcggg ttcgggaagg tgttcgccgg
    21421 agcgccgctc gtgccggaga agaccatgtt ccagacgccg ccgtcccagc tgccgtagct
    21481 gctgtccctg gtgtaccact gctgctgcga gatcgacgcg gcctgaccgg agaccttggt
    21541 gtcggcggtg tagccgccgc tcgcgaagcc gtagctggcc ggatagagct ggagcccgcc
    21601 ccggatgtcc atccggcgga acggcgcggc ctgcgcgacg gcccagcggg tcgagccgct
    21661 gctcgggacg acggcgaggt tctccgccga gcgccagaag ttctgcagcg ccacgccctt
    21721 gtccgactcg ttgaacgcgt cgacggtgac gtcaccgttg atcaccacgt cgcccgggtt
    21781 ctgcccgagt cccgcgaccg aggtgtagta gccgacgttg tcgtggatgc cgttgtacac
    21841 accgggcttg aacaggtgcg cgtaccggcg ctcggtgaac tgcgcggtca gggtgtcctt
    21901 ctgcgcgttg aagtccgcgt cgagccgcga ctggatcgac gccgcggaca tcccggggtc
    21961 gaagatccgc acgttcgggc cgaagtccgg gacctcggcc tgagccggac aggtcccctg
    22021 tgccgatccg atcgtgtaag ccgccgagga caccggggag ttcgccgagc cggccttgag
    22081 cgcgatcgcg gagatcgtcg aggacgcgga gaccgtgatc ggcccggtgt acacagtgga
    22141 cgacgccgtc ggcgtggaac cgtccactgt gtaccggatg gtcgcgccgg cggtcgcgct
    22201 cgacagggtc accgaacggg cgctcgggta actgccgccc ggcggatcga aggtcggcga
    22261 cgcgacggtc gtgccgctgc cgccgtgggt gtaggtgaag tgcggggtgt cgtattgcgg
    22321 cccgttcttc tcgtaggtga accagtagtc gagcaccgtg cccgccgaca gcgagccgat
    22381 ggtgtgccgc cacgtgcctc cgttgtcggt catgcggacg ttctgctgcc cgacacccgg
    22441 gacgcccgtg tagtggatgt cgacgtaacg cgccggggtc gccggcgtga acgagaactg
    22501 cgcctgggtc gcgttcaagg acgcggcgct ctggctgtag tcggcggccg cggcggtggc
    22561 accgccgatc cccgccgcga tcaggagtgc ggaaaggccg agggcgagcg cgccccgaac
    22621 ccctttccgc cgtttgggct gcacaaagat ccgattcacg tcgtgacacc tccggcgttg
    22681 gaaatccacg ggcgaagcaa ttcgttgcgc gccacaacaa agtagccgtc cgtgcgatat
    22741 gtccagatca cgcttcggta acactggtgg tccaaaccac tgactacgcc aggcggtcca
    22801 cggcgacagg accgttcggc gccatcgaca ggagcgtttg ggggctggtc agcggtctgg
    22861 gacgacgtag a
//
