LOCUS       NC_021252              24226 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1633770
            Orig. end                         :: 1657996
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24226
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="4"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24226
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24226
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14226](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14226)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(530..1081)
                     /locus_tag="AORI_RS48735"
                     /old_locus_tag="AORI_1546"
     CDS             complement(530..1081)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423200.1"
                     /locus_tag="AORI_RS48735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1546"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_016331939.1"
                     /transl_table=11
                     /translation="MEQTGDRELWARAADGDEGAFSELFERHAETLWNYTYRLTGSWSS
                     AEDLASTTFLIAWRRRAEVTLVRDSALPWLYTVAANVARDEHRGARRRLRLLGKIPAQP
                     AVSDHADSVAEKIDGQRRLKQVAEAVRSLPKSQREVVELCLAAEVGIADAAELLGIAEV
                     TVRAHLSRGRARLRTLLEEK"
     gene            1185..2627
                     /locus_tag="AORI_RS48740"
                     /old_locus_tag="AORI_1547"
     CDS             1185..2627
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646460.1"
                     /locus_tag="AORI_RS48740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1547"
                     /product="hypothetical protein"
                     /protein_id="WP_016331940.1"
                     /transl_table=11
                     /translation="MIMEQVRTTDNQAPPWRMPLSTAVLSAVVFLLARPHLIDDTYITL
                     AYARNVAFHGHWGLLADATSNTATSPANVLVLAALTIVVRDAVFAAGVLFVLCQVLLAL
                     ALRRLGTACGLPSRFPALTLGALTANPLLLSSIGLEVALGAAVLGWLTVFAVEKNPFAF
                     GLTAGTLALVRLDLIVFAVVLFVFLRPGVGRALLGAGLITLPWFGFSWVALGAAVPDTV
                     VIKTLQGAQHAWGAWNFGNGPLFYARVSPVMVVLAFLPAVLAVVALAIRLRTSPAGLRP
                     FAALAVGGLLYHLGYVLLAVPPYHWYYGPGLTAATVVLCAVAVSHRFMVSGVLALIVAG
                     LIAYAAAGLPRTYAPFTSNYTSSAQYARIGAELGTLAGGRTVGSAGEIGVLAYSCGCPV
                     VDVFSDRGLLPAAIEARGEENRWIRAMLRVNYAFFDFDVRPRRPELLLRRLAAPPPDAL
                     AHWTLDAPTLGKQELYLVPNKE"
     gene            2688..3296
                     /locus_tag="AORI_RS48745"
                     /old_locus_tag="AORI_1548"
     CDS             2688..3296
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AORI_RS48745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AORI_1548"
                     /product="hypothetical protein"
                     /protein_id="WP_016331941.1"
                     /transl_table=11
                     /translation="MVITTWVQAAGTVLLGLVGLWFAHNYRRQIRLKLAERQVESYVRL
                     WALTAPAAPFRATPLEPGELKKLYDDMGKWYFDDGDGILTSSAARDLFIGVHGNLVCPV
                     GEMKPAVLAAQLAALPPADAERRRGCAIIRQISLLRTQLKKDLAMHFGVGYYTDLQPDD
                     RAFLVSCGLSPRRRPWRPRRLRPADRPRVDSCVCGACPS"
     gene            3463..7530
                     /locus_tag="AORI_RS48750"
                     /old_locus_tag="AORI_1549"
     CDS             3463..7530
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="AORI_RS48750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1549"
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_123798310.1"
                     /transl_table=11
                     /translation="MDVEQFSGRKNPEQRNVRSAVYAALAHALGSHWSACHREDRGDGV
                     FLLAPADVPKQLFVERVPGRLVKALNRHNRAHGTGEQIRLRMAVHAGEVLLDEHGATGV
                     AINHTFRLLDSPPLKDALAGSAGVLAVITSDWLFREVVWHSAADETRYRPQRIRVKETE
                     TVGWICLPDDPYPPDVSQAEWPEDVCPYPGLRAFQPDQARWFFGREATLSVLMEKIDHR
                     GGPVFVVAPSGAGKSSLLRAGVITEVADSGRPWLLLTPAKEPCETLAQQVAQLIDGDVD
                     DVRSAVGSDPARPASMLPDGTVVVVDQFEEVFTLCADEAERRRFIAALIAMRAVLGVRG
                     DFYDHCLADDQLAKFLPASQFNLQAMTPAGLRAAIERPARQIGVDVEPGLVEILLHEIG
                     TDAGGLPLLAHALAVTWQRRAGDKLTLADYDRAGRIQGAIAATADEAYARCSTAEQRVI
                     FQQILMHLVVVRHDAPPARRRADPADLVQGFDAPRTAETVLGWLIEKRLVTLDGNVVEL
                     SHGVLLRAWPQLGTWIETGRNDQVIRQQLIEAAEQWEREGKPVGSLYRGDRLAIARGWR
                     SRSEHRAALTPLGAAFLGASIRHESRRARVRRTAVAMLAVLGLVASSAAVYAFQQRDIA
                     REQRDAAIFNKVTAEANRIRTVDVSLAAQLDLVAYRMRPADADTGTHLIVDANAPLSAT
                     LPAGAKDVSVVAFSPDGRTLATGSGSGDRLVRLWNVADPAHPVLLNETISHGEATRALA
                     FSPDGRTLGSGGADNTVRLWNVADPARPEALGPPITGHTKTIRSMAFSPDGRTLASAGD
                     DRTVRLWNVADLARPTALGPPMAGHTDAVYSVAFSPDGRTLATGGDDRTMRLWDIAAPD
                     RAEPFGPPLTGHTGAFHSVAFSPDGRMLAGASNDREVRLWNVADPARPEAVGRPITGHA
                     GAIRSLAFGPGGRTVATGGDDYTVRLWDVADPARPSPIGAPITGHADGVRSMAFSPDGR
                     VLATASGDRAVRLWNIPDTVLKGHTREVKALAFSPDGRILATGGGDRTVRLWTPADRRQ
                     LGRPLTGHQDDINALTFRPDGRVLATGGGDRTVRLWDVADPARPSPIGAPITGHADGVR
                     SMAFSPDGRILVTGGDVKDENTARLWDVADPAEPVLLARIEIGPDANALAVAFSPDGRT
                     LATGTEYSDVAVRLWNVSDPAKPTLLTGPLKGHQDDIRRIAFSPDGRTLASGGDDAQVR
                     LWDVTDPAHATPLGEPLAGHTNPVIGLAFSPDGHTVASGSGDNTVRLWRTADRTQSGQP
                     LTGHQAAVNTVAFSPDGATLATGSQDHTVRLWNMTVPQAVHGICAVTGNTLTREMWDKF
                     VSAELPYSPPCS"
     gene            complement(7759..9288)
                     /locus_tag="AORI_RS48755"
                     /old_locus_tag="AORI_1550"
     CDS             complement(7759..9288)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225919.1"
                     /locus_tag="AORI_RS48755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1550"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_046199759.1"
                     /sec_met_domain="DAO (E-value: 7.6e-11, bitscore: 41.1,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPRDPRRVTRQAPPGLADAGLLGRRPTAAIVGGGIAGLTAATG
                     LAERGVTVTVFEREDHLGGRVGGWRERLPDGTAVTMSRGFHAFFRQYYNLRALLARTDP
                     RLDRLTPLTDYPLLDAHGRIDTFAGLPRTPPWNAMAFAWRSPTFTRRDLLHLSGREALP
                     LATVSVPEIYHRLDRTDASTFLEAINFPPAAKHLAFEVFSRSFFADPRELSAAELATMF
                     HLYFLGSSEGLVFDVPTEPFPQALWDPLANHLTGRRADIRTGTTVTGLGRTPEGFAVES
                     DGRTENFDGVVLACDVSGLREIVAASPDVGTEAWRADVGGLRTAPPFLVRRLWLDRPVE
                     PRRPPFLGTGSIPPLDNISLLDRYEGEARRWAARTGGSVVELHAYAAATEDSSGLEKAL
                     ESRLHEIYPETRDARVVGDITLWREDCPLFGVGDFARRPTVATPDPALALAGDGIRIDL
                     PVALMERAAATGWSAANTLLGHWGLAGHPIRSVPNHGRIRLLNRLAASKSG"
     gene            complement(9285..10004)
                     /locus_tag="AORI_RS48760"
                     /old_locus_tag="AORI_1551"
     CDS             complement(9285..10004)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020674249.1"
                     /locus_tag="AORI_RS48760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1551"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_016331944.1"
                     /transl_table=11
                     /translation="MNAMARNGLPREAVPSAFDTEARFYDRLVGANPGYHEHLRLSARR
                     LAAPGPRVLDAGCGTGASTAALLSVLPSARITAFDASGEMLERARSKTWPGNVEFVHTP
                     VEELAGIHGPFDGILAAYLLRNLTDPTTQLRRLRALLRPGGRIAVHEYSVGDSRRARWI
                     WNAVCAGVIIPLGKLTTGDATLYRHLRRSVLEFDGITALARRLTDAGFTDVHTATVGGW
                     QRDIVHTVVGTAPSEPV"
     gene            complement(10001..10321)
                     /locus_tag="AORI_RS48765"
                     /old_locus_tag="AORI_1552"
     CDS             complement(10001..10321)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033027.1"
                     /locus_tag="AORI_RS48765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1552"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_016331945.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 9.6e-19,
                     bitscore: 66.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPWGYTVPAVVSVIVVVLFELAVLKTGLFRKPAYWLTMAIVTGF
                     QIPVDGWLTKLSAPIVLYAPEHITGWRFPWDIPVEDFLFGFAMVTAVLLLWERARSREE
                     AR"
     gene            complement(10318..10659)
                     /locus_tag="AORI_RS48770"
                     /old_locus_tag="AORI_1553"
     CDS             complement(10318..10659)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225922.1"
                     /locus_tag="AORI_RS48770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1553"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_016331946.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 1.6e-20,
                     bitscore: 72.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKIEYLLVLAACVLVTLPLELAGARVYRQPKRLARALLPVAVVF
                     LVWDAVAIAGEVWGYAPEFVTGIRAPFSLPLEEILFFVVIPICGVLTYEAVQLTLAAVQ
                     RREKQAVRR"
     gene            complement(10659..11615)
                     /locus_tag="AORI_RS48775"
                     /old_locus_tag="AORI_1554"
     CDS             complement(10659..11615)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225923.1"
                     /locus_tag="AORI_RS48775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1554"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_016331947.1"
                     /sec_met_domain="phytoene_synt (E-value: 6.6e-119,
                     bitscore: 395.0, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.3e-62,
                     bitscore: 210.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAAEIHDPGLRAAYTWCRDVNARHGRTYFLATRMLTPAQ
                     RPAVHALYGFARWLDDIVDEPAADATPDSLAARLSEVEDRFLADLTAGTSDDPLLTAVI
                     DTAARYELEEGLFRDFFTSMRMDLSVTDYATRDDLDEYVRGSAEVIGLQVLPILGAVAP
                     REEAAPRAAALGKAFQLTNFLRDVAEDFERGRVYLPADELKEHDVDRERLSWCAEHGRA
                     DVRVRAAIKEQIAVTRRVYAEARPGIAMLHPVSRPCVATAATLYGEILDRIEDAGHDVF
                     AGRAKVSRRRRLGVACGALVRAQWARKRHPAPPSAVG"
     gene            complement(11612..13129)
                     /gene="crtI"
                     /locus_tag="AORI_RS48780"
                     /old_locus_tag="AORI_1555"
     CDS             complement(11612..13129)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033024.1"
                     /locus_tag="AORI_RS48780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1555"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_016331948.1"
                     /sec_met_domain="DAO (E-value: 1.2e-22, bitscore: 79.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTVPGRTDRIVVVGAGLSGLAAALHLAGRGREVTVLERDPGPGG
                     RAGRAEHQGYLLDTGPTVLTMPSILRDTFGAVGAELDRELPLTRLDPAYLAQFADGSAL
                     PVHTDAAAMTDAVREFAGPAEAAGYLRLRDWLTRLYHAEFGRFIDSNIDSPLGMLNPDL
                     ARLVALGGFRRLDAKIGSFLSDERLKRVFTFQALYAGESPMRALALYAVISYMDTVGGV
                     YFPPGGVAALPQALARVAAENGVTFHYGDPVHALERDGSRVHAVRTAAGERHPCDAVVL
                     TTELPESYRLLGRTPARPVPLRPAPSALILHTGGPDTGPDVGHHTISFGHGWRSTFDEL
                     ITTGRRMSDPSLLITRPTATDPGLAPPGRQLYSILAPVPNLDRGPADWTAEAGPYAEEI
                     LAVARQRLLPDFEPEFTEIISPADWADRGHVAGTPFSYAHSFVQTGPFRPRNLPRGTEN
                     VVLAGGATVPGVGVPTVLISGRLAADRITGVPGRRSRVLDLATEASR"
     gene            complement(13126..14226)
                     /locus_tag="AORI_RS48785"
                     /old_locus_tag="AORI_1556"
     CDS             complement(13126..14226)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225925.1"
                     /locus_tag="AORI_RS48785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1556"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_016331949.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.6e-40, bitscore:
                     137.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASTMAAGTVPPKEARAAWLDEVGRRCLAEAHGFVEARAAEHFSG
                     RGEGELAETVLPQFLAGGKFLRPMFAYVGWRCGGPESDAALRAASSLELLHCFALAQDD
                     VMDASALRRGRPALHVRFARWHAEQGWSGSADRFGESAATLAGDLFLVWSEQLLRESGL
                     DTETLSRGWPRYDAMRAELAVGQLADLVNDARTLPGWDALLDVLRRKSGNYTVRRPLEF
                     GAALAGCGPDVMAALAEYGGLVGEAFQFKDDLLGVFGDPTVTGKPAGQDLRDRKASSVV
                     VLAAEMADGRRRAELGELLNLTTVDDDAVSRWCELITATGARERLGELIRERADKALAV
                     IDPAVVPQEAADALAVLAIRCTERDQ"
     misc_feature    complement(14281..14299)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.22"
                     /tool="antismash"
     misc_feature    complement(14283..14300)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     gene            14639..15517
                     /locus_tag="AORI_RS48790"
                     /old_locus_tag="AORI_1557"
     CDS             14639..15517
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163824.1"
                     /locus_tag="AORI_RS48790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1557"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_016331950.1"
                     /transl_table=11
                     /translation="MDVDEMSGLGGGSWTPGKVAEILGVSPVTLRTWDSRYGVGPTIRA
                     GGRHRRYSDADVRRLQHMQRLIDRGIPAREAAAAAFSGTGETVPDVPADRLVGELEQAA
                     EDLEFASIAALLDETLGAIGAAATWADVLLPILRGLGDRWSRGDVCFESEWALTTEVSL
                     ALQRYVARFSTGPSERGVLIACCPDERHSLPVEVLRASLAEIGVPAVHLGQMVPAETLA
                     GLASRLDPVLVVLWSMSASTVDVLLCERLQRQGSEVVVAGPGWEGLNVRGAPWVNDLTT
                     ALDVVAARFKA"
     misc_feature    14981..14983
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15589..16617
                     /locus_tag="AORI_RS48795"
                     /old_locus_tag="AORI_1558"
     CDS             15589..16617
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419105.1"
                     /locus_tag="AORI_RS48795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1558"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_016331951.1"
                     /transl_table=11
                     /translation="MDLRRQVVERWPAKWPVQPFREPAWARQEPTYRECSPALIDAAVK
                     RADARPAGNWFVVAASREVVADRPLGLRAGGRELVAWRGPDGDLVIGPGACPHLGAPLD
                     QARVHCGELVCRWHGLRVGPERPGWSRLPSHDDGVLAWVRLDRFGGETPTERPIVPARP
                     EGDVTIDAVATLTGTCEPVDVVANRLDPWHGAWFHPYSFTRLKVLSAPQGNDVTDAEDK
                     FVVEVTFRLAGKLGVPVIAEFTCPEPRTVLMTIVDGEGAGSVVETHATPLGTGPDGRPR
                     TAVIEATIATSDRPGFAKAARIAPALRPLMRRASARLWRDDLAYAERRYALRAGDVADG
                     RA"
     gene            16793..17758
                     /locus_tag="AORI_RS48800"
                     /old_locus_tag="AORI_1559"
     CDS             16793..17758
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AORI_RS48800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AORI_1559"
                     /product="hypothetical protein"
                     /protein_id="WP_016331952.1"
                     /transl_table=11
                     /translation="MRKAVLSAVLGASLAFTVTTALPVTAAATPSVAPCTWVVSDLPVP
                     AGADGGSVAVAGPNGYLAGAVWKDNKRVNVLWHNREVVEMPQPPNGAALQFSAISGRGE
                     VVGYQSSTDVSAGFRYHDGVYETLPSPPGVRATATAINESGDIVGYIGDGRVPYQVILW
                     PANAPGSYRIIADGKAVGIDNAGRVVTEPGLVWSPDGSTRQLAGYGDLVIKRYQGERIV
                     GMSWTQGEQLIEWDVNTGAVLGKTPGNTVMGINANGLLAAWYFNNDGSNTLGIWWNRTF
                     IGDFAPASRISAVTDDNQLAGSHGPASPWVPATWSCVSAP"
     gene            complement(18336..18953)
                     /locus_tag="AORI_RS48805"
                     /old_locus_tag="AORI_1560"
     CDS             complement(18336..18953)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419028.1"
                     /locus_tag="AORI_RS48805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1560"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_016331953.1"
                     /transl_table=11
                     /translation="MTPTEQAAAGRRAPATRDLLYEAATALFVERGYEDTTMADIAQRA
                     GTSRRTAFNHFPSKGDIPMLWTRRMADRAVEVITEATEEAVPERVRAYFRLISRMVEAE
                     PELSRQMMLGWTAAGGPIRYESQLLADLTPLLRNGQERGEVDPGVDVAEAARTLSDVYA
                     GVIFRWVRDPDTSRTLQTTADSAIDLVLSAIRAGGRTPSAWR"
     misc_feature    complement(19033..19048)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.58"
                     /tool="antismash"
     gene            19061..20266
                     /locus_tag="AORI_RS48810"
                     /old_locus_tag="AORI_1561"
     CDS             19061..20266
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331954.1"
                     /locus_tag="AORI_RS48810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1561"
                     /product="cytochrome P450"
                     /protein_id="WP_228688317.1"
                     /sec_met_domain="p450 (E-value: 2.1e-11, bitscore: 42.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNITSSMRPSDLDLYQPEALLDPYAHYAKLRELGPVLFDPEREI
                     WLVPGYAEASGVLRNHKEFVSGDGVTYEGVGDRLERYPLIENDPPVHTRIRRAVQPAFT
                     KGPIEQLRPAIEAAAKSIAEKAVALGEIDAVQAVAQPMPDKAMELLTGLTPPSAQTLAD
                     WSDAVVRAQEPAASARHSELLIEALNWLTEVGVPGLPAHCLGRLITESGGANRGLEADG
                     SERLMTLASIWLAGIDSTGAMLGNAIGAFIEHPDQWELLRARPDLIPNAVEELLRFEAP
                     FRIFYRRTRAETEIGGTTIPASAAVCAVLASANRDPRQFPDPDRLDVTRENARTHLSFG
                     TSIHLCLGSPLARLEATSMLTELTRRVLRFERTGEPVRSPSQTMRKFDSLPVRLVPAPG
                     VA"
     gene            20266..21210
                     /locus_tag="AORI_RS48815"
                     /old_locus_tag="AORI_1562"
     CDS             20266..21210
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) SubclassB2"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419030.1"
                     /locus_tag="AORI_RS48815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1562"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_043847952.1"
                     /transl_table=11
                     /translation="MSGYSKGPHDLGGDCHAWLLPDGGWGESNTGLVRGAGVSLLVDTL
                     YDLPHTAEMLDAYRPLTASHPIRTLVNTHSDGDHWFGNQLVAGPDVEIVASEAAAELMT
                     PRAVSEMASLHNRGDRVGQFIHSVGGRFNLTGITPAPPTRTFAGELDLDVGGRQVRLIQ
                     VGPAHTPGDVLVHVPDAKVVYTGDILFVGGAPLVWAGPVSRCIAACDRILDLELTAIVP
                     GHGPLTDKDGVRLVRDYLAFVEVEATKRFEEGLSVEQAVASMNLGRFAAMSEQGRIAAN
                     VLNVYEELDPDRPRADRLEQFSRIAAFELGEPA"
     gene            21207..22190
                     /locus_tag="AORI_RS48820"
                     /old_locus_tag="AORI_1563"
     CDS             21207..22190
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419031.1"
                     /locus_tag="AORI_RS48820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1563"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_016331956.1"
                     /transl_table=11
                     /translation="MKIARIQIEGTTRVGIVDGDQVQPLAADTDMSELLAATPAQRAEF
                     VQRATEGEPRPLSEVRLLVPVQPRTLRDFLTFEEHLEGSLKLLGAPAPHPAWYDQPLFY
                     FSNTNAVMGPDDPVAVPPGCRLLDFELELAAVIGKPGKDLSPEQAAEHIAGYTLFNDWS
                     ARDLMSPVVPVGMGPVKGKDFANTLGPWIVTADELAPYRRDGRLALEMHAELNGAALPA
                     GGDNSANMSWSFEEMVAFASRGAELVPGDVLASGTCGAGCLLEYWAHTDSEEPPPLRPG
                     DVVTLVVEGIGSVSNPIVAGAEPVAVPRARVEQRRRARPWNTAGSS"
     gene            22166..24127
                     /locus_tag="AORI_RS48825"
                     /old_locus_tag="AORI_1564"
     CDS             22166..24127
                     /EC_number="6.2.1.16"
                     /GO_function="GO:0030729 - acetoacetate-CoA ligase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019287 - isopentenyl diphosphate
                     biosynthetic process, mevalonate pathway [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (98-523). E-value: 4.6e-52.
                     Score: 168.9. Matches aSDomain:
                     nrpspksdomains_AORI_RS48825_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331957.1"
                     /locus_tag="AORI_RS48825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_1564"
                     /product="acetoacetate--CoA ligase"
                     /protein_id="WP_016331957.1"
                     /sec_met_domain="AMP-binding (E-value: 7.6e-57, bitscore:
                     191.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHRGVVVSAEVWTPTAQAAAEATITAFARFAGRRGGPPPGASYE
                     ELWRWSVDDTTEFWSAVAEFCEMAWDTQPDAVTDGAPMPETRWFPGGRLNYAAQVFRTP
                     RTGVAVVGHDETGISQTLTWAELEAQVSGLAATLAGLGVRAGDRVVGYLPDRPESIVAF
                     LATASLGAVWGGCGTDLAGDAARARLAQLDPAVLVAASGHHHRGQWIDRTTDVRKLREG
                     LPTLRATVLVGDGHATDVTTLAWAQAVSPPAQRVEPVPVLAEHPLWVLFTSGTTGPPKG
                     IVHSHAGVVVEHLKTLSLHLEVRPGDQFFWYTTLNWMMWNLRMGGLLRGATVHCFDGAP
                     TVRALWQVAERGGVTHLGLSPGYLSASRDAGLHPAADFDLPALRVVGCTGSVLTAPLHQ
                     WAAEELGPEVLVGSTTGGTDVVSGFAGFALTAPIRAGEIAVRCLGVDLQAWSPDRKPLT
                     DAVGELVVTSPMPSMPLRFWNDPDGSRYRGAYFEEFPGVWRHGDWVTVTGRGSVIVHGR
                     SDATLNRHGIRMGSADICQAVEDLPEVDEALVVGIEEPDGGYWMPMFVTLSGGRHLDEE
                     LAAAVWAAVRDRVSPRHVPDEVIEAPGIPHTRTGKKLEVPVKNILRGFTATVQKDAVDR
                     PELLEFYRQTGEDRRRTR"
     aSDomain        22460..23734
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AORI_RS48825_AMP-binding.1"
                     /evalue="4.60E-52"
                     /label="AORI_RS48825_AMP-binding.1"
                     /locus_tag="AORI_RS48825"
                     /protein_end="523"
                     /protein_start="98"
                     /score="168.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QVFRTPRTGVAVVGHDETGISQTLTWAELEAQVSGLAATLAGLGV
                     RAGDRVVGYLPDRPESIVAFLATASLGAVWGGCGTDLAGDAARARLAQLDPAVLVAASG
                     HHHRGQWIDRTTDVRKLREGLPTLRATVLVGDGHATDVTTLAWAQAVSPPAQRVEPVPV
                     LAEHPLWVLFTSGTTGPPKGIVHSHAGVVVEHLKTLSLHLEVRPGDQFFWYTTLNWMMW
                     NLRMGGLLRGATVHCFDGAPTVRALWQVAERGGVTHLGLSPGYLSASRDAGLHPAADFD
                     LPALRVVGCTGSVLTAPLHQWAAEELGPEVLVGSTTGGTDVVSGFAGFALTAPIRAGEI
                     AVRCLGVDLQAWSPDRKPLTDAVGELVVTSPMPSMPLRFWNDPDGSRYRGAYFEEFPGV
                     WRHGDWVTVTGRGSVIVHGRSDATLN"
     CDS_motif       22970..23044
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AORI_RS48825_0001"
                     /evalue="2.40E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="AORI_RS48825"
                     /protein_end="293"
                     /protein_start="268"
                     /score="23.1"
                     /tool="antismash"
                     /translation="VLFTSGTTGPPKGIVHSHAGVVVEH"
     misc_feature    complement(24185..24199)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
ORIGIN
        1 ggccaggacg gatccagcac cccgccgatc agtccggtcg cgctctgcac gagcagcccg
       61 gtgcgggtgc ccggcatgta cgcgggggcg gcgtccggat cggacacggt cacggtggtc
      121 agcgtcgtct cgcagaacat cggcttgccc gccgccgtcg cggcgacgac cgaaacgccc
      181 agcatgacgt cggtgaacag ggggacccat tcctcgcgcg gggccagccg gtccgacttg
      241 cccgcggccc gcaccgccgc ccagcagcgg tcgagcgacg acgtcgccag cgcggtgtcc
      301 agagtgagcc cgccggccgc cggttcgggg ccgggggccg cgccctgctg acggagcgac
      361 tgcgccgcgg cggcgacgcc ggacgcgacg agaacgaccg ccgccgcggc ggcgtaccag
      421 acgcgtgccc tccgccgcgg cttcgcgatc ccctcgcgga cggccgatcg catccgggcg
      481 cggacgtcgt ccggcatcgc gtggtgaggc gggtacacgg gttcgtcgct catttctcct
      541 ccagcaacgt acgcagccgg gctcgtcccc gggaaagatg ggcgcggacg gtgacctcgg
      601 cgatgcccag cagctccgcg gcgtcggcga tgcccacctc ggcggccagg cagagttcga
      661 cgacctcgcg ctgcgatttc ggcagcgacc ggacggcttc ggcgacctgc ttcagccggc
      721 gctggccgtc gatcttctcg gccaccgagt cggcgtggtc ggatacggca ggctgggccg
      781 ggatcttccc gagcagccgc agccggcggc gagcaccgcg gtgctcgtca cgggcgacgt
      841 tggccgcgac cgtgtagagc cacggcaggg cgctgtcccg caccagggtc acttcggccc
      901 gccgccgcca cgcgatgagg aacgtcgtgg acgccaggtc ctcggcgctg ctccacgaac
      961 cggtcaggcg ataggtgtag ttccacagcg tctcggcgtg ccgctcgaac agctcactga
     1021 acgccccctc gtcgccgtcg gccgcgcggg cccacagttc ccggtcaccg gtctgttcca
     1081 ccggttctcc caacccgatc gcaaggttgc tcacgccctg gttgtggccg gcaccgctcg
     1141 aacgttgcgc gcaacttccc ggggcggagg agccacatcg agacatgatc atggaacagg
     1201 tccggacgac ggacaaccag gcgccgccct ggcggatgcc cctgtccaca gcggtgctct
     1261 cggcggtggt gttcctgctc gcccgtccgc atttgatcga cgacacgtac atcacgctgg
     1321 cgtacgcgcg caatgtcgcc ttccacggcc actggggcct gctcgccgac gcgacgtcga
     1381 acaccgcgac gtcgccggcg aacgtgctcg tcctggcggc cctgaccatc gtcgtccgcg
     1441 acgccgtctt cgccgctgga gtgctgttcg tgctctgcca ggtccttctc gccctggcgt
     1501 tgcgcaggct cggcacggcg tgcgggctgc cgtcccggtt ccccgccctg acgctcggcg
     1561 cgctgaccgc gaacccgctt ctcctctcgt cgatcgggct cgaggtcgcc ctcggcgcgg
     1621 ccgtcctggg ctggctcacc gtgttcgccg tcgagaagaa cccattcgcc ttcgggttga
     1681 cagccggcac gctcgccctg gtccggctgg acctgatcgt gttcgcggtg gtgctcttcg
     1741 tcttcctccg tcccggagtg ggacgcgcac tactcggcgc cgggctgatc acgttgccgt
     1801 ggttcggttt cagctgggtg gcgctcggcg cggcggtacc ggacaccgtg gtgatcaaga
     1861 ccctccaggg tgcgcaacat gcttggggcg cttggaactt cggcaacggc ccgctgttct
     1921 acgcgcgggt ttcaccggtg atggtcgtgc tggcgttcct gcccgccgtc ctcgccgtgg
     1981 tggcactggc catccggctg cggacgagcc cggcgggcct gcggccgttc gcggcgctcg
     2041 ccgtcggcgg cctgctctac cacctcggct acgtgctgct ggccgtcccg ccctaccact
     2101 ggtactacgg gcccggcctc accgcggcga ccgtcgtcct ctgtgccgtg gcggtttcac
     2161 accggttcat ggtcagcggg gtgctcgcgc tgatcgtcgc cggtctgatc gcgtacgcgg
     2221 ccgccggact tcctcgtacg tacgcaccgt tcacgtcgaa ctacacgtcg agcgcgcagt
     2281 acgcccgtat cggggcggaa ctcggcacgc tcgccggagg ccggaccgtc ggcagcgcgg
     2341 gcgaaatcgg tgtcctcgcc tacagttgcg gctgcccggt cgtcgacgtc ttctccgacc
     2401 gaggcctgct gcccgccgcg atcgaggcgc gcggcgagga gaaccgctgg attcgcgcga
     2461 tgcttcgcgt gaactatgcc ttcttcgact tcgacgtccg gccacggcgt cccgaactcc
     2521 tgctgcgacg gctggcggct cctccaccgg acgcgctcgc gcactggacg ctcgatgcgc
     2581 cgactctcgg gaagcaggag ctgtacctgg tgccgaacaa ggagtgaggt ggtgcggctt
     2641 ccaggcctca cactggtagc catcgtcgag ctgggagttg acgtgacatg gtgatcacga
     2701 cgtgggttca ggcggccgga accgtgttgc tggggctggt cgggctctgg ttcgcgcaca
     2761 actaccggcg gcagatccgg ctcaaactcg ccgaacgtca ggtcgagtcg tacgtgcggc
     2821 tctgggcgct gaccgcgccc gccgccccgt tccgtgctac tccgttggag cccggagagc
     2881 tgaaaaagct ctacgacgac atgggaaagt ggtacttcga cgacggcgac ggcatcctca
     2941 cctcgtccgc ggctcgcgac ttgttcatag gcgtccacgg caatctcgtc tgcccggtcg
     3001 gcgagatgaa accggccgta ctggccgcgc aactcgccgc gttgcccccg gccgacgccg
     3061 aacgccgtcg cggttgcgcg atcatccgcc agatatcgct tttgcgaacc cagctgaaga
     3121 aggatttggc tatgcacttc ggcgtcggct attacaccga tcttcagccc gatgatcgag
     3181 cttttctggt cagctgtggt ttgtctcccc ggcggcggcc gtggcgacca cgccggctgc
     3241 gtccagcgga ccggccacgt gtcgattcat gcgtgtgcgg cgcctgtcca agctgatgcg
     3301 ggacaccctt aatcctgaat actttcaatc ggtttcacgc gaacgagtga aagctcatca
     3361 ggctctgtac ggctgcgggg actatggcgg catctttggc cgagtgacgt gatctgggga
     3421 ggtctcatgt cgcctaccgc gctgcatcac actgttctgg ttgtggacgt ggagcaattc
     3481 agcggccgga agaatccgga acagaggaat gtgcgcagcg cggtctacgc ggccttggct
     3541 catgcgctcg gctcgcactg gagcgcctgc catcgcgaag accggggcga tggtgtgttt
     3601 cttctggcac cggcggatgt tccgaagcag ctgttcgtcg agcgggtgcc cggtcgcctg
     3661 gtgaaagcgt tgaacaggca caaccgggcg cacgggaccg gcgagcagat ccggctgagg
     3721 atggccgtgc acgccgggga agtcctgctc gacgagcacg gcgcgaccgg cgtcgcgatc
     3781 aaccacacgt tccgattgct cgactcgccg ccgttgaagg acgccctcgc cggctcggcc
     3841 ggtgtgctcg cggtgatcac ctccgactgg ttgttccgtg aagtggtctg gcacagcgct
     3901 gccgacgaga cccgctatcg gccccaacgc atccgggtca aggaaacgga gacggtggga
     3961 tggatctgcc tgccggacga cccgtacccg cccgacgtca gtcaggcgga gtggccggag
     4021 gacgtctgcc cctatcccgg tctgcgtgcg ttccaacctg accaagcgcg gtggttcttc
     4081 ggccgtgaag cgaccttgtc ggtgttgatg gagaagatcg atcaccgcgg cgggccggtc
     4141 ttcgtcgtcg caccgtccgg tgccggcaag tcgtcgctgc ttcgggcagg cgtgatcacc
     4201 gaggtggccg acagtggacg cccgtggctg ttgctcaccc cggcgaagga accttgcgag
     4261 acactggcac agcaggtcgc gcagctcatc gacggcgacg tggatgacgt gcgctcggcg
     4321 gtcggatccg atcctgcccg gccggcgagc atgctgcccg acggcaccgt cgtcgtggtg
     4381 gaccagttcg aagaggtgtt caccctgtgc gccgacgagg ccgagcggcg gcggttcatc
     4441 gccgcattga tcgcgatgcg ggcggttctc ggggtgcggg gcgacttcta cgaccactgc
     4501 ctcgccgacg atcagctcgc gaagttcctg ccggcgagcc agttcaacct ccaggcgatg
     4561 actccggccg gattgcgggc ggccatcgaa agacccgctc ggcagatcgg cgtcgacgtc
     4621 gaaccgggcc tggtcgagat cctcctgcac gagatcggga cggacgcggg cgggctcccg
     4681 ctgctggccc atgccttggc cgtcacctgg cagcggcgcg cgggcgacaa gctgaccttg
     4741 gcggattacg accgggcagg gcggatccaa ggcgcgatcg cggccaccgc ggacgaggcc
     4801 tacgcgcggt gttccacggc cgagcagcgc gtgatcttcc agcagatcct catgcacctg
     4861 gtcgtggtca ggcacgacgc gccgcctgcc aggcggcgcg cggatccggc cgacctcgtc
     4921 cagggtttcg acgcaccgcg gaccgctgag acggttctcg gctggctgat cgagaaacgt
     4981 ctggtcacgc tggacggcaa cgtcgtcgag ctttcccacg gagtgttgct gcgggcgtgg
     5041 ccgcagctcg gcacctggat cgagacgggc cgcaacgatc aggtcatccg gcagcagttg
     5101 atcgaggccg ccgaacaatg ggagagagaa gggaaaccgg tcggatcgct gtatcgcggc
     5161 gatcggctgg ccatcgcgcg ggggtggcgg tccaggagtg agcaccgcgc cgccctcacg
     5221 ccgctcggag cggccttcct cggcgcgtcg atccggcacg aaagccggcg ggccagagtc
     5281 cgccggaccg cggtcgccat gctggccgtc ctcggccttg tcgcgtccag tgccgccgtc
     5341 tacgccttcc agcaacgcga catcgcccgt gagcaacgtg acgccgcgat cttcaacaag
     5401 gtcaccgccg aggcgaaccg gatacggacc gttgacgtgt cgctggcggc ccagctcgat
     5461 ctcgtcgcct accgcatgcg cccggccgac gcggacaccg gcacccactt gatcgtcgac
     5521 gcgaacgcgc cgctgtccgc gacgttgccc gcgggtgcca aggacgtcag cgtggtggcg
     5581 ttcagtcccg atgggcggac gctggccacc ggcagcggca gcggcgaccg actcgtgcgg
     5641 ttgtggaatg ttgccgaccc ggcccatccg gtgctgctga acgaaaccat cagtcacggt
     5701 gaggcaaccc gggcgctggc gttcagcccg gacggacgca ctctgggctc gggcggcgcc
     5761 gacaacacgg tgcggctgtg gaacgtcgcc gacccggccc gccccgaggc gctcggcccg
     5821 ccgatcacgg gacacaccaa gacgatccgg tcgatggcgt tcagtcccga cgggcggacg
     5881 ctggccagcg cgggggacga tcgaaccgta cggctgtgga acgtcgccga cctcgcccgg
     5941 cccacggcgc tcggcccgcc gatggccggg cacaccgacg ccgtctactc cgtggcgttc
     6001 agccctgatg gccggactct ggccaccggc ggcgacgacc ggacgatgcg actgtgggac
     6061 atcgccgcgc cggaccgggc cgaacccttc gggccaccgt tgaccgggca caccggcgct
     6121 ttccattcgg tggcgttcag tcccgatgga cggatgctgg ccggtgcgag caacgaccgg
     6181 gaagtgcggc tgtggaacgt cgccgacccg gcccgccccg aggcggtcgg caggccgatc
     6241 acggggcatg ccggcgcgat ccggtcgctg gcgttcgggc ccggcggacg gacggtggcc
     6301 accggcggcg atgactacac cgtgcggctg tgggacgtcg ccgatccagc tcgcccttcg
     6361 cccatcggtg cgccgatcac cgggcatgcc gacggcgtcc ggtcgatggc gttcagcccg
     6421 gacggccgtg tcttggccac cgccagtggc gaccgggcgg taaggctgtg gaacataccc
     6481 gacaccgtcc taaaaggaca tacgagagaa gtcaaggcgt tggcgttcag ccctgacggg
     6541 cgcatcctgg ccaccggcgg cggcgaccgg accgtccggt tgtggacgcc tgccgatcgg
     6601 cggcagctgg gccggccgct caccggccac caagacgaca tcaacgcctt gacgttcaga
     6661 ccggatggcc gcgtgctggc caccggcggc ggtgaccgga ccgtgcggct gtgggacgtc
     6721 gccgatccag cccgcccctc gcccatcggc gcgccgatca ccgggcatgc cgacggagtc
     6781 cggtcgatgg cgttcagccc cgatggccgc atcctggtca ccggcggcga tgtgaaggac
     6841 gagaacaccg cacggctgtg ggacgtcgcc gacccggccg aacccgtgtt gctggcccgg
     6901 atcgagatcg gaccggacgc caacgccttg gcggtggcgt tcagcccgga cgggagaact
     6961 ctggcgacgg gaaccgaata cagcgacgtc gcggtgcggc tgtggaacgt ttccgatccg
     7021 gccaagccca cgctgctgac cggccccctc aaagggcacc aggacgacat acgccggatc
     7081 gcgttcagcc cggatgggcg gaccttggcc agcggcggcg acgacgctca ggtgcggctg
     7141 tgggacgtca ccgatcccgc tcacgccaca ccgctcggcg aacctcttgc gggccatacc
     7201 aaccccgtca tcgggttggc gttcagcccg gatggacaca cggtggccag cggcagcggc
     7261 gacaacaccg tgcggctctg gcggacagcc gaccggacgc agtcggggca gccgctcacc
     7321 ggacaccagg ccgccgtcaa cacggtggcg ttcagcccgg atggcgccac cctcgccacc
     7381 ggcagccaag accacaccgt gcggctgtgg aacatgaccg tgccccaagc cgtgcacggc
     7441 atctgcgccg tcacggggaa cacgctcact cgcgagatgt gggacaagtt cgtgtcggcc
     7501 gaactgccgt acagtccgcc gtgttcctga cccgctagtg ctcggcgtgg accacacgaa
     7561 agccactttc gggacatcag acgtcgcgaa agtggctttc gcgacacggg cgccgtcggc
     7621 gcgggtgagt gaccggggtg aaggctccct tcgccgcatt agacgcggcg aagggagcct
     7681 tcgccccacc gccgacccac ccgtgaccac gacacctttc acttacctct cgataaccgg
     7741 ctccagggga gcatccgctc agccggactt cgaggcggcc agccggttca gcaggcggat
     7801 ccgtccgtgg ttggggaccg agcggatcgg gtgcccggca aggccccagt gcccgagaag
     7861 ggtgttcgcc gcgctccagc cggtggcggc cgcgcgttcc atgagggcga ccgggaggtc
     7921 gatccggatg ccgtcgcccg cgagcgcgag cgccgggtcc ggggtcgcca ccgtgggccg
     7981 ccgggcgaag tcgccgacgc cgaacagcgg gcagtcttcg cgccacaacg tgatgtcgcc
     8041 gaccacgcgg gcgtcccggg tttccgggta gatctcgtga agacggcttt ccagtgcctt
     8101 ttccaacccg ctcgagtcct cggtggcggc cgcgtaggcg tgcagttcga cgaccgatcc
     8161 gccggtgcgc gcggcccagc gccgggcttc tccctcgtac cggtcgagca ggctgatgtt
     8221 gtccagcggc gggatgctcc cggtgccgag gaacggtggc cgacgcggct cgaccgggcg
     8281 gtccagccag agccgccgga ccaggaaagg cggggcggta cgcaaaccgc cgacgtcggc
     8341 tcgccacgcc tcggtgccga catccggtga agcggcgacg atttcgcgca gcccggagac
     8401 gtcgcaggcg aggaccacgc cgtcgaagtt ctccgtccgg ccgtctgatt cgacggcgaa
     8461 accttccggg gtccggccga ggccggtcac cgtcgtgccg gtgcggatgt cggcgcggcg
     8521 gccggtgaga tggttcgcga gcgggtccca gagcgcttgg gggaacggct cggtcggtac
     8581 gtcgaagacc aggccttcgc tggagccgag gaagtacagg tggaacatgg tcgccagctc
     8641 ggcggccgac agttcacgcg ggtcggcgaa gaagctgcgc gagaagacct cgaacgcgag
     8701 gtgcttggcg gcgggcggga agttgatcgc ttcgaggaag gtcgaggcgt cggtgcggtc
     8761 gagccggtgg tagatctccg gcacgctgac cgtcgccagc ggcagcgcct cgcggccgct
     8821 gaggtgcagc agatcccggc gggtgaaggt cgggctacgc caggcgaaag ccatcgcgtt
     8881 ccacggcggg gtgcgcggaa gtccggcgaa ggtgtcgatg cggccgtgtg cgtccaacag
     8941 cgggtagtcg gtcagcgggg tcagccggtc caaccgcgga tcggtgcgcg cgagcagggc
     9001 gcgcaggttg tagtactggc ggaagaacgc gtggaagccc cggctcatgg tcaccgcggt
     9061 gccgtccggg agccgctccc gccagccgcc gacgcgcccg ccgagatggt cttcgcgttc
     9121 gaagacggtg acggtgacgc cgcgttcggc cagcccggtc gccgcggtga gcccggcgat
     9181 gccgccgccc acgatcgcgg cggtggggcg ccgtccgagc agtccggcgt cggccagccc
     9241 cggcggggcc tgccgggtca cgcgacgggg atccctgggg cgggtcacac cggctccgag
     9301 ggcgcggtgc cgacgacggt gtggacgatg tcccgctgcc agccgccgac ggtcgcggtg
     9361 tggacgtcgg tgaagccggc gtcggtgaga cgccgggcga gtgcggtgat gccgtcgaat
     9421 tcgaggacac tgcggcgaag atgacggtag agtgtggcgt cgccggtggt gagtttcccg
     9481 agcgggatga tcacgcccgc gcagacggcg ttccagatcc agcgggctcg gcgggagtcg
     9541 cccacggagt actcgtgcac ggcgatccgg ccacccggcc ggagcagtgc gcgaagccgg
     9601 cgtagctgtg tggtcggatc ggtgaggttg cgcaggaggt acgccgccag gattccgtcg
     9661 aacgggccgt ggatcccggc cagttcctcg accggtgtgt gcacgaattc gacgttgccg
     9721 ggccaggttt tgctccgggc ccgctccagc atctcgccgg acgcgtcgaa ggcggtgatg
     9781 cgggcgctcg gcagcaccga caggagggcc gccgtggacg caccggttcc gcagccggcg
     9841 tccagcaccc gcggtccagg agcggcgagc cgccgggcgg aaaggcgcaa atgctcgtgg
     9901 tagccgggat tcgcgccgac gagacggtcg tagaaccggg cttcggtgtc gaaggcggaa
     9961 ggcacggcct cgcgcggcaa accgtttcgc gccatggcgt tcatcgcgct tcctctcgtg
    10021 atcgggctcg ttcccacagc agcagcacgg cggtcaccat cgcgaagccg aagaggaagt
    10081 cttcgaccgg gatgtcccac gggaaccgcc agccggtgat gtgttcgggc gcgtagagga
    10141 cgatcggcgc ggacagcttg gtcagccagc cgtcgacggg gatctggaag ccggtgacga
    10201 tcgccatggt gagccagtag gcgggtttgc ggaacagccc ggtcttcagc acggcgagct
    10261 cgaacagtac gaccacgatc accgagacga cggccggaac ggtgtaaccc caagggatca
    10321 tcgccgaacc gcctgcttct cgcgccgctg gaccgcggcg agggtgagct ggaccgcttc
    10381 gtaggtcagc accccgcaga tcgggatcac gacgaagaac aggatctctt ccagcggaag
    10441 ggaaaacggc gcgcggatac cggtgacgaa ctcgggcgcg taaccccaga cctcgccggc
    10501 gatcgccacc gcgtcccaga cgaggaagac cacggccacc gggagcagcg cgcgggcgag
    10561 gcgtttcggc tgccggtaga cgcgggcgcc cgcgagttcc aacggcagcg tcaccaggac
    10621 acatgccgcc aatacgagca ggtattcgat cttgcccatc agcccaccgc cgacggggga
    10681 gcgggatgtc gtttccgggc ccactgcgcg cgaacgagcg cgccgcaggc gaccccgaga
    10741 cggcgacgcc gggacacctt cgcccggccg gcgaagacgt cgtggccggc gtcttcgatc
    10801 cggtcgagga tttccccata aagggtcgcg gcggtggcga cgcagggccg tgagaccggg
    10861 tgcagcatcg cgatgcccgg ccgcgcctcg gcgtagacgc gccgggtcac cgcgatctgt
    10921 tccttgatcg cggcccggac gcggacgtcg gctcggccat gctcggcgca ccaggagagc
    10981 cgttcgcggt cgacgtcgtg ttccttgagt tcgtcggcgg gcagatagac cctgccgcgc
    11041 tcgaagtcct cggcgacgtc gcggaggaag ttggtcagtt ggaaggcctt cccgagtgcg
    11101 gcggctcgcg gtgccgcctc ttcgcgaggc gcgaccgcgc cgaggatcgg gagcacttgc
    11161 aggccgatca cctccgccga accgcgcacg tactcgtcga ggtcgtccct ggtggcgtag
    11221 tcggtgacgc tcaagtccat ccgcatcgac gtgaagaagt cgcggaagag cccttcctcc
    11281 agctcgtacc tcgccgcggt gtcgatcacc gccgtcagca ggggatcgtc actcgtaccc
    11341 gcggtcagat cggcgagaaa ccgatcctcc acttcggaca gtcgcgcggc gagggagtcc
    11401 ggggtggcgt ccgcggcggg ctcgtcgacg atgtcgtcca gccatcgtgc gaaaccgtag
    11461 agcgcgtgga cggcgggccg ttgcgctggc gtcagcatgc gggtcgccag gaagtacgtc
    11521 cggccgtgcc gggcgttgac gtcgcggcac caggtgtacg cggcccgcag gccgggatcg
    11581 tggatctcgg cggcatcgag ttcgcgtcgg gtcatcggct cgcctccgtg gccaggtcga
    11641 ggacgcgcga gcggcgtccg ggaacgccgg tgatccggtc ggcggccagc ctgccggaga
    11701 tcagcacggt cggcacaccc actcccggca ccgtcgctcc tccggcgagg acgacgttct
    11761 cagtgccgcg aggaagattc cgagggcgga acggtcctgt ttggacgaac gagtgcgcgt
    11821 agctgaaggg cgttccggcc acgtgcccgc ggtcggccca gtcggcgggg ctgatgatct
    11881 cggtgaactc gggttcgaaa tccggcagga gccgctgccg cgcgacggcg aggatctcct
    11941 ccgcgtacgg tccggcctcg gcggtccaat ccgcggggcc tcggtcgaga ttcgggaccg
    12001 gcgcgaggat cgagtagagc tgacggcccg gcggcgccag gcccgggtcg gtcgcggtcg
    12061 gccgggtgat cagcagcgac ggatcgctca tgcggcggcc cgtggtgatg agttcgtcga
    12121 aggtcgagcg ccacccgtga ccgaaggaaa tggtgtggtg cccgacatcg ggcccggtat
    12181 cggggccgcc ggtgtgcagg atcagtgccg acggcgcggg ccgcagcgga acgggccgcg
    12241 ccggagtccg gccgagcagc cggtagctct cgggtagctc ggtcgtgagg acgacggcgt
    12301 cgcacggatg acgttcgccg gcggccgtgc ggaccgcgtg gacccggctg ccgtcgcgtt
    12361 cgagcgcgtg cacggggtcg ccgtagtgga aggtgacgcc gttctcggcg gcgacccggg
    12421 cgagcgcctg gggcagtgcc gcgaccccgc cgggcggaaa gtacacgccg ccgacggtgt
    12481 ccatatagga gatgaccgcg tacagcgcca gcgcccgcat gggcgactcg cccgcgtaga
    12541 gcgcttggaa ggtgaacacc cgcttcagcc gctcgtcgga caggaaggac ccgatcttcg
    12601 cgtccagccg ccggaatccg cccagcgcca ccagccgggc cagatccggg ttgagcatgc
    12661 ccagcggtga gtcgatgttc gagtcgatga accggccgaa ctcggcgtgg tagagccggg
    12721 tcagccagtc gcgcagccgc aggtatcccg cggcctcggc aggcccggcg aactcgcgta
    12781 ccgcgtccgt catcgccgcg gcgtcggtgt gcacgggcag ggcgctgccg tcggcgaact
    12841 gtgccaggta ggccgggtcg agccgggtga gcggcagttc cctgtccagt tccgcgccca
    12901 cggcgccgaa ggtgtcccgc aggatcgacg gcatggtcag caccgtcgga ccggtgtcga
    12961 gcagatagcc ctggtgttcg gcgcgccccg cgcggccgcc ggggccgggg tcgcgttcga
    13021 ggacggtgac ttcgcggccg cggcccgcca ggtgcaacgc ggccgccagc cccgacaacc
    13081 ccgctcccac gacgacgatc cggtccgtcc tgccgggcac cgttttcact ggtcgcgctc
    13141 cgtgcaccgg atggcgagta cggccagcgc gtccgctgcc tcctgcggga cgacggccgg
    13201 gtcgatcacc gcgagcgcct tgtcggcgcg ttcccggatg agttcgccga ggcgttcgcg
    13261 tgcgccggtg gccgtgatca gttcgcacca gcgggagacg gcgtcgtcgt cgacggtcgt
    13321 caggttcagc agttcgccga gttcggcacg ccgccgcccg tcggccatct ccgcggcgag
    13381 caccacgacg ctggacgcct tgcgatcgcg gaggtcctgg ccggcgggtt tgccggtgac
    13441 cgtgggatcg ccgaagacac cgagtaggtc gtccttgaac tggaacgcct cgccgaccag
    13501 gccgccgtac tcggcgaggg cggccatgac gtccggaccg cagcccgcca gcgcggcgcc
    13561 gaactccagc ggcctgcgga cggtgtagtt gccggatttg cggcgcagca cgtcgagcag
    13621 cgcgtcccag ccgggaagtg tccgggcgtc gttcaccaga tcggcgagtt gccccaccgc
    13681 cagttccgcg cgcatcgcgt cgtacctcgg ccagccgcgc gacagcgttt ccgtgtccaa
    13741 accggactcc cggagcaact gttcggacca gacaaggaaa aggtcaccgg cgagagtcgc
    13801 cgcggattcg ccgaaccggt cggcggagcc actccacccc tgttcggcat gccaccgcgc
    13861 gaaccgcacg tgcagtgcgg ggcggccccg gcgcagcgcc gaggcgtcca tgacgtcgtc
    13921 ctgcgccagc gcgaaacagt ggagcaattc caagctcgac gcggctcgca gcgcggcgtc
    13981 cgattccggg cctccgcacc gccagccgac ataggcgaac atcggccgga ggaatttccc
    14041 tccggcgagg aactggggaa ggacggtttc cgcgagctcg ccctcgccac ggccggagaa
    14101 gtgctcggcg gcccgtgctt cgacgaaacc gtgggcttcg gcgagacaac gcctgcccac
    14161 ctcgtccagc caggcggccc gcgcctcctt cggcggcacc gttcccgccg ccatggtcga
    14221 cgccatccgc cttccctccg ccgatccggt gatttcgttt cataaccgtt tcacgcctgg
    14281 ggtatcctgt ctactagatc cagtggcgca cccgcaactc gagccatatc ggccggagag
    14341 caaggaaatc ctgggtttcc cgggatctcc cggctcaaac ccggatcgct cgcggatcga
    14401 agaagaccgt ctttcggacg agagtggccc ggaccccgcc accctcagga gcccggtgcc
    14461 ccctcgcgcc gggctccgga tgcccgacgg cgcctggcgt gcggaccggt cccttcccgg
    14521 ggccccgccg tggcgccgtc gggcgttctt cgttccgggg acggtgtgcg cctgtccatg
    14581 cccggtgacc tcgtaagctg cccttcgggc gaacactggc accgggaacg tggaacggat
    14641 ggatgtcgac gagatgagcg gccttggcgg cggttcgtgg acccccggca aggtcgccga
    14701 gatcctgggc gtctcgccgg tcacgctccg cacctgggat tcgcggtacg gggtcggccc
    14761 caccatccgc gcgggtggcc gtcatcgccg ttactcggac gcggatgtcc gcaggttgca
    14821 gcatatgcag cggctgatcg accgggggat tcccgcccgc gaggcggccg ccgcggcgtt
    14881 ctccggtacc ggtgagacgg tcccggacgt acccgccgac aggctggtcg gcgaactcga
    14941 gcaggccgcg gaagacctgg aattcgcctc catcgcggcg ttactggacg aaacgctcgg
    15001 cgcgatcggc gcggcggcga cgtgggccga cgtgttgctg ccgatcctgc gcggcctcgg
    15061 ggaccgctgg tccaggggtg acgtgtgctt cgagtcggaa tgggcgctca ccaccgaggt
    15121 ttcccttgcg ctgcaacgct acgtcgcccg attcagcacc gggccgtccg aacgcggagt
    15181 gctcatcgcc tgctgcccgg acgagcggca cagcctgccg gtcgaggtcc tccgggcgtc
    15241 cctggcggag atcggtgtcc ccgccgtcca cctcggtcag atggtgcccg cggagacctt
    15301 ggccgggctg gcgtccagat tggatccggt gctggtggtg ctgtggtcga tgtccgccag
    15361 caccgtcgat gtcctgctgt gcgagcgtct gcaacggcag gggtccgagg tcgtcgtcgc
    15421 cggccccggc tgggaaggac tcaacgtccg tggcgcgcct tgggtcaacg atctgaccac
    15481 cgcgctggac gtcgtcgccg cccgcttcaa agcctgaacc gttgcgggat cgcttcaggt
    15541 gcctgaggat ggatccggaa gcggacgcgg gacagggagg attccccggt ggatctcagg
    15601 cggcaggtgg tcgagcgctg gccggcgaaa tggccggtcc agccgttccg ggagccggcc
    15661 tgggcccggc aggaaccgac ctaccgcgaa tgcagtcccg cgctgatcga tgccgcggtc
    15721 aaacgggccg acgcgcggcc ggcgggcaac tggttcgtcg tcgcggccag ccgggaggtc
    15781 gtcgcggatc ggccactggg tctgcgcgcc ggcggccggg aactggtggc gtggcgtggt
    15841 ccggacggtg acctggtcat cggccccggt gcctgcccgc atctcggtgc tccgctcgat
    15901 caggctcgtg tccattgtgg agagttggtc tgccggtggc acggattgcg ggtcgggccc
    15961 gagcggccgg gctggtcacg gctgccctcc catgacgacg gtgtgctcgc ctgggtccgc
    16021 ctcgaccgct tcggcggcga aacccccacc gagcggccga tcgtgccggc ccgtccggaa
    16081 ggcgacgtca ccatcgacgc ggtcgcgacg ctgaccggga cctgcgaacc ggtggacgtc
    16141 gtcgcgaacc ggctcgaccc ttggcatggc gcgtggttcc atccgtactc gttcacccgg
    16201 ctgaaggtgt tgtcggctcc acaagggaac gacgtcaccg acgccgagga caagttcgtc
    16261 gtcgaagtga ccttccggct cgccgggaaa ctgggcgtgc cggtgatcgc cgagttcacc
    16321 tgccccgagc cgcggacggt gctgatgacc atcgtcgacg gcgaaggcgc gggcagcgtg
    16381 gtcgaaaccc acgccacacc gctcgggacc ggccccgacg gacgaccacg gaccgccgtg
    16441 atcgaggcga cgatagccac gtccgaccgt cccggtttcg ccaaggccgc ccgcatcgcc
    16501 ccggctctgc ggcccctgat gcgccgagcg tccgcgcgtc tctggcggga cgacctcgcc
    16561 tacgccgagc ggcgctatgc cttgcgagcg ggagacgtcg ccgacgggcg ggcatgaaac
    16621 cggcgccggg atcgtgggat cccgggctgg agatcccgac gtcgccgggg tgtacagcgt
    16681 tcgaaggacg aacacaggga atccccgcac actcgccggt caccaaggca accatggtga
    16741 ccagtcgtgc gtgaacccga agaccgcttc ctgcgttcca aggggttatt ccatgcgtaa
    16801 ggccgtacta agcgccgtac tcggcgcgtc gctcgcgttc accgtcacca ccgccctccc
    16861 cgtcaccgcg gctgccacac cctcggtggc gccctgtacc tgggtcgtct ccgacctgcc
    16921 tgtccccgcc ggagccgacg gtggctcggt ggccgtcgcc ggaccgaacg ggtatctggc
    16981 cggcgcggtg tggaaggaca acaaacgcgt gaacgtgctg tggcacaacc gcgaggtcgt
    17041 cgaaatgccg cagccgccga acggcgccgc gctccagttc tccgccatca gtggccgcgg
    17101 cgaggttgtg ggttatcagt cctcgaccga tgtcagcgcg ggattccgtt accacgacgg
    17161 cgtttacgag accctgccga gtccgcccgg ggtgcgggcc accgccaccg ccatcaacga
    17221 gtccggtgac atcgtggggt acatcggcga tggacgagtg ccctatcagg tcatcctctg
    17281 gccggcgaat gctcccggca gctaccggat catcgccgac ggcaaagcgg tcggcatcga
    17341 caacgcgggc cgggtggtga ccgagcccgg gctggtgtgg tcgcccgatg gttccacccg
    17401 gcagctggcc gggtacggcg atctcgtcat caagcgatac cagggcgagc ggatcgtcgg
    17461 catgtcatgg acccagggcg agcagctcat cgagtgggac gtgaacaccg gtgccgtgct
    17521 gggcaagaca ccggggaaca ccgtgatggg catcaacgcg aacggcctgc tcgcagcgtg
    17581 gtatttcaac aacgacggct cgaacacgct cggcatctgg tggaatcgaa ccttcatcgg
    17641 cgacttcgcc ccggccagca ggatctccgc ggtcaccgac gacaaccagc tcgccggttc
    17701 gcacggcccg gcgtctcctt gggtacccgc tacgtggagc tgcgtttccg cgccatgacc
    17761 ggcacttcgg atcgaatcgg tatgtggtgc ctgatgcgcc ggtcaacggt cgcgtcggtg
    17821 agatggagtt ctcgttgacg tcgaggctgg tgaagatccg cggtaggtgg cccgcccgcc
    17881 gggtgagagt cccaaagtga gacggaacga aaaaccgccc tacctcggca aagctgccag
    17941 gtgggcggtt tttcgcactg tggaggctag gggactcgaa cccctgaccc ctcactgcca
    18001 gtcaggttcg ggcaggtcgc tgacctgcgg ttatcgggaa ctcgctggtc ggctggtgca
    18061 gttgtgctct gttcgatgcg gtccggtgtc gttgggcgct gttgtaaccg acggtgcgct
    18121 ccacttcgcc gtgggctcga aacctggctc ctgtgggcgc cactctcgga gtcggcggac
    18181 cactgctcgc aatgttcagt ctgcctgtgc atgccgtgtc gacggcgtcc gctcatgccg
    18241 atgtgcggtg gcgacttcga ggtcagccat gggggtacga ggatcgctga gccggttgcg
    18301 gtcgagcagg gcgggctgga cctgttccgc agccttcacc gccacgcgct cggcgtcctg
    18361 ccgcccgccc ggatggccga caggacgagg tcgatcgcgc tgtccgccgt cgtctgcagt
    18421 gtccgggacg tgtccgggtc ccgtacccag cggaagatca ctcccgcgta gacgtcgctg
    18481 agggtgcgtg ccgcctcggc aacgtccacc cccggatcga cttctccgcg ttcctggcca
    18541 tttctgagca gaggtgtcag gtcggccagc aactgtgact cgtaacggat ggggccgccc
    18601 gccgcggtcc agccgagcat catctgccta ctcagctcgg gctccgcctc caccatacgg
    18661 ctgatcagcc gaaagtaggc gcggacccgt tccggcaccg cttcctccgt ggcctcggtg
    18721 atcacctcca cggcgcggtc cgccatccgc cgcgtccaca acatcgggat gtcgcccttg
    18781 ctggggaagt ggttgaacgc cgtgcggcgc gaggtgcctg cccgctgggc gatgtccgcc
    18841 attgtggtgt cctcgtagcc acgctccacg aacaaggccg tcgcagcctc gtagagcaga
    18901 tcacgggtgg ccggagcgcg ccggcccgct gcggcctgtt cagtgggtgt caccgccgct
    18961 ctcgcccctt cccgatgctt gacatcaact gcacccgagt gcaagcatcc ctcgcgcagt
    19021 gactgcactc gagtgcaaaa ctcgtcacaa gggagtgacc atgtccaaca taacgtcctc
    19081 gatgcggccc agtgacctcg acctctacca gccggaagcg ctgctcgatc cgtacgcgca
    19141 ctacgcgaaa ctgcgcgagc tgggaccggt gctcttcgat ccggagcgcg agatctggct
    19201 ggtgcccggc tacgccgagg catcaggtgt gctgcgcaat cacaaggagt tcgtctccgg
    19261 cgacggggtc acctacgagg gggtcggcga ccggctcgaa cggtatccgc tgatcgagaa
    19321 cgacccgccg gtgcacaccc gcatccgccg ggcggtccag ccggcgttca ccaagggccc
    19381 gatcgagcag ctgcggcccg cgatcgaggc cgccgcgaaa tcgatcgccg agaaagccgt
    19441 cgcgctcggc gagatcgacg ccgtccaggc ggtggcccag ccgatgcccg acaaggccat
    19501 ggaactgctg accgggctca ccccgccgag cgcccagacg ctggctgact ggagcgacgc
    19561 ggtcgtccgc gcgcaggaac cggcggcgag cgcgcgccac tccgagctgc tgatcgaagc
    19621 actgaactgg ctgaccgagg taggcgttcc cggcctgccg gcgcactgcc tcggccggct
    19681 gatcactgag tccggaggcg cgaacagggg gctcgaagcc gacggctcgg aacggctgat
    19741 gaccctcgcc tccatctggc tggcgggcat cgactcgacc ggcgcgatgc tgggcaacgc
    19801 gatcggagcg ttcatcgagc accccgacca gtgggagctg ctgcgcgccc ggcccgacct
    19861 gatcccgaac gcagtcgagg agctgctgcg cttcgaggct cccttccgca tcttctaccg
    19921 ccgcacgcgt gccgagaccg agatcggcgg aaccacgatc ccggccagtg ccgcggtgtg
    19981 tgccgtactt gcctcggcga accgcgatcc tcggcagttc cccgatcccg accggctgga
    20041 cgtgacccgg gagaacgccc gcacgcacct gtcgttcggg acgtcgatcc acctgtgcct
    20101 cggctcgccg ctggcgcggc tggaggccac gtcgatgctg accgagctca cccgccgggt
    20161 gctgcggttc gagcgcaccg gcgagccggt gcgcagcccc agccagacca tgcgcaagtt
    20221 cgactccttg ccggtgcggc tggtaccggc cccgggagtg gcgtgatgag cgggtactcg
    20281 aagggacccc atgacctggg cggcgactgc cacgcctggc tgctgcccga cggcggctgg
    20341 ggggagagca ataccgggct ggtgcgcggc gcgggggtgt cactcctggt ggacacgctc
    20401 tacgacctcc cgcacaccgc ggagatgctc gacgcttacc gcccgctgac cgcgagccat
    20461 ccgatccgga ccctggtcaa cacccactcc gacggcgacc actggttcgg caaccagctg
    20521 gtcgccgggc ccgatgtgga gatcgtcgcg tcggaggcgg cggcggagct gatgaccccg
    20581 cgcgcggtgt ccgaaatggc ctccctgcac aaccgcgggg accgcgtcgg ccagttcatc
    20641 cactcggtcg gcggccgctt caacctgacc gggatcaccc cggccccgcc cacccgcacc
    20701 ttcgccggcg agctcgacct cgacgtcggc gggcgccagg tgcggctcat tcaggtcggt
    20761 ccggcacaca cgcccggcga tgtgctggtc cacgtgccgg acgcgaaggt cgtctacacc
    20821 ggggacatcc tcttcgtcgg tggtgctccg ctcgtgtggg caggaccggt ctcgcggtgc
    20881 atcgccgcct gcgaccggat cctcgacctc gaactcaccg cgatcgtgcc cgggcacggc
    20941 ccgctcaccg acaaggacgg cgtccggctg gtccgggact acctcgcgtt cgtggaggtc
    21001 gaagcgacca agcggttcga ggaagggctc agcgtcgaac aggccgtcgc gtcgatgaac
    21061 ctcggccggt tcgcggcgat gtccgagcag ggacggatcg cggccaatgt gctcaacgtc
    21121 tacgaggagc tcgatccgga caggccgcgc gcggaccggc tggagcagtt cagccggatc
    21181 gccgccttcg aactcggaga gccggcatga agatcgcgcg aatccagatc gagggaacga
    21241 ccagggtggg catcgtcgac ggcgaccagg tacagccgct cgccgcggac accgacatgt
    21301 ccgagctgct cgccgcgacc ccagcacagc gcgcggagtt cgtccaacgc gccacggagg
    21361 gcgagccacg cccactgtcc gaggtgcggc tgctcgtgcc cgtgcagccc aggacgctgc
    21421 gggacttcct caccttcgag gagcacctgg aaggcagcct gaagctgctc ggcgcgccgg
    21481 cacctcaccc cgcctggtac gaccagcccc tgttttactt ctccaacacc aatgcggtga
    21541 tgggacccga cgacccggtc gcggtgccgc cggggtgccg gctgctggac ttcgagctgg
    21601 agcttgccgc cgtcatcggt aagcccggca aggacttgag cccggagcag gcggccgagc
    21661 acatagccgg gtacaccctg ttcaacgact ggtccgcgcg ggacctgatg tcgccggtgg
    21721 tcccggtcgg catggggccg gtgaagggga aggacttcgc caacaccctc gggccgtgga
    21781 tcgtcaccgc cgacgagctc gcgccctacc gccgcgacgg ccggctggcg ctggagatgc
    21841 acgcggagct caacggtgcc gcgctgcccg cgggcgggga caactcggcc aacatgtcct
    21901 ggtcgttcga ggagatggtc gcgttcgcct cgcgcggcgc ggagctggtg cccggtgatg
    21961 tgctcgcctc ggggacctgc ggggccggct gcctgctcga atactgggcc cacacggaca
    22021 gcgaggagcc cccgccgctg cggccgggcg atgtcgtgac gctggtcgtc gagggcatcg
    22081 gttcggtgtc gaacccgatc gtcgccgggg ccgagccggt ggccgtgccg agggcccggg
    22141 tggagcagcg gcgacgtgcg cgcccgtgga acaccgcggg gtcgtcgtga gcgccgaggt
    22201 ctggacaccg acagcccagg cggccgccga ggcgacgatc accgcgtttg cccgcttcgc
    22261 agggaggcgg ggcggcccgc cacccggcgc gtcctacgag gagctgtggc ggtggtcggt
    22321 cgacgacacg accgagttct ggagcgccgt ggccgagttc tgcgaaatgg cttgggacac
    22381 ccagcctgac gcggtcaccg atggtgcccc catgccggaa acccgctggt tccctggcgg
    22441 gcgcctcaac tacgccgccc aggtgttccg gaccccgcgc accggagtgg cggtcgtggg
    22501 ccacgacgaa accgggatca gccagaccct gacctgggcg gagctggagg cgcaggtgag
    22561 cggcctcgcc gccaccctcg ccgggttggg ggtccgcgcg ggcgaccggg tggtcgggta
    22621 tttgcccgac cgccccgagt cgatcgtggc cttcctggcc acggcgagcc tgggggcggt
    22681 ctggggcggc tgcggtacag acctggccgg ggacgccgct cgagcccgcc tcgcccagct
    22741 ggacccggct gtcctcgtcg ccgcctcggg ccaccaccat cgggggcagt ggatcgaccg
    22801 caccaccgac gtgcggaagc tgcgggaggg attgccgact ctgcgtgcga ccgtgctcgt
    22861 cggcgacggt cacgcgacgg acgtgaccac cctcgcttgg gcgcaggccg tctctccacc
    22921 cgcacaacgc gtggagccgg taccggtact cgcggagcat ccgctgtggg tgctgttcac
    22981 ctcgggaacg accggccccc cgaagggcat cgtgcacagc cacgccggcg ttgtcgtcga
    23041 gcacctcaag accctgagcc tgcatctgga agtccggcca ggggaccagt tcttctggta
    23101 cacgacgctg aactggatga tgtggaacct ccggatgggc gggctgctcc ggggagcgac
    23161 cgtccactgt ttcgacggcg cgccgacggt gcgcgcgctc tggcaggtcg ccgagcgcgg
    23221 cggggtcacg cacctcggcc tcagccccgg ctatctgagc gcctctcgcg acgcggggct
    23281 gcaccccgcc gcggacttcg atctcccggc cctgcgggtg gtcggctgca cgggatccgt
    23341 gctcaccgcc ccgttgcacc agtgggcggc cgaggaactc ggcccggagg tcctggtcgg
    23401 gtccaccacc ggcgggacgg acgtggtcag cgggttcgcc ggcttcgcgc tcacggcgcc
    23461 catccgggcc ggggagatcg ccgtccgctg tctgggggtc gatctccaag cctggtctcc
    23521 tgaccggaag ccgctgaccg acgcggtggg ggagctggtc gtcacctcac cgatgccgtc
    23581 gatgccgctc cgcttctgga acgacccgga cggcagccgc taccgcggcg cctacttcga
    23641 ggaattcccc ggggtgtggc ggcatggcga ctgggtgacc gtgaccggcc gcggatcggt
    23701 gatcgtgcac ggccgctcgg acgccacgct caaccggcac ggcatccgca tgggcagcgc
    23761 cgacatctgc caggcggtcg aggaccttcc cgaggtcgat gaggcgctgg tggtcggcat
    23821 cgaggagccc gacggaggct actggatgcc gatgttcgtc actctctccg gcggacggca
    23881 cctcgacgag gaactcgctg ccgcggtgtg ggccgcggtc cgcgaccggg tgtcaccgcg
    23941 gcacgtcccc gacgaggtga tcgaggcacc ggggatccct cacacccgca caggcaagaa
    24001 gctggaagta ccggtcaaga acatcctgcg gggcttcacc gcaacggtcc agaaggacgc
    24061 cgtcgaccgg cccgaactcc tggagttcta ccggcagacc ggcgaggacc gccgccgcac
    24121 cagatgagga aagccatgcc cattcccgag accttcgaag ttgtcgtgct cagcaaggag
    24181 accgtggccg acggagtcgt cctgctcacg ctgggtcggc cggacc
//
