LOCUS       NC_021252              22544 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Amycolatopsis keratiniphila, complete sequence.
ACCESSION   NC_021252
VERSION     NC_021252.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis keratiniphila
  ORGANISM  Amycolatopsis keratiniphila
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis; Amycolatopsis japonica group.
REFERENCE   1  (bases 1 to 8948591)
  AUTHORS   Tang,B., Wang,Q., Yang,M., Xie,F., Zhu,Y., Zhuo,Y., Wang,S., Gao,H.,
            Ding,X., Zhang,L., Zhao,G. and Zheng,H.
  TITLE     ContigScape: a Cytoscape plugin facilitating microbial genome gap
            closing
  JOURNAL   BMC Genomics 14, 289 (2013)
   PUBMED   23627759
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8948591)
  AUTHORS   Xu,L., Zhao,W., Ge,M. and Zhao,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2012) Shanghai Laiyi Center for Biopharmaceuticals
            R&D, Shanghai 201203, China
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000400635.2
            Current Name                      :: Amycolatopsis keratiniphila
            Previous Name :: Amycolatopsis orientalis HCCB10007
            Date Updated                      :: 2018-10-26
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_001620365.2
            A1 Name                           :: Amycolatopsis keratiniphila
            A1 ANI                            :: 96.94781%
            A1 Query Coverage                 :: 84.86%
            A1 Subject Coverage               :: 83.93%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_000478275.1
            A2 Name :: Amycolatopsis orientalis HCCB10007
            A2 ANI                            :: 90.22668%
            A2 Query Coverage                 :: 73.73%
            A2 Subject Coverage               :: 73.08%
            ##Taxonomic-Update-Statistics-END##
            ##Assembly-Data-START##
            Assembly Method                   :: Newbler v. v2.5
            Sequencing Technology :: Sanger dideoxy sequencing; 454; Illumina
            ##Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000400635.2-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 02:04:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,307
            CDSs (total)                      :: 8,242
            Genes (coding)                    :: 8,193
            CDSs (with protein)               :: 8,193
            Genes (RNA)                       :: 65
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 49
            CDSs (without protein)            :: 49
            Pseudo Genes (ambiguous residues) :: 0 of 49
            Pseudo Genes (frameshifted)       :: 14 of 49
            Pseudo Genes (incomplete)         :: 33 of 49
            Pseudo Genes (internal stop)      :: 3 of 49
            Pseudo Genes (multiple problems)  :: 1 of 49
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:56:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 381926
            Orig. end                         :: 404470
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP003410.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria available from Shanghai Laiyi Center for
            Biopharmaceuticals R&D, Shanghai 201203, P.R. China,
            hccbred@gmail.com.
            The organism was changed from 'Amycolatopsis orientalis HCCB10007'
            to 'Amycolatopsis keratiniphila' in October 2018.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22544
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22544
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12544](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(344..358)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.82"
                     /tool="antismash"
     gene            352..582
                     /locus_tag="AORI_RS84115"
     CDS             352..582
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AORI_RS84115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_228688285.1"
                     /transl_table=11
                     /translation="MFNHLKPAKAGGDPSVFATATRVIDYSDLKAFSRLENGDKIVDGK
                     IVDADGNPVEVRDEEGRPVSYRIGSEPDAHG"
     gene            621..1529
                     /locus_tag="AORI_RS42805"
                     /old_locus_tag="AORI_0367"
     CDS             621..1529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633028.1"
                     /locus_tag="AORI_RS42805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0367"
                     /product="hypothetical protein"
                     /protein_id="WP_016330816.1"
                     /transl_table=11
                     /translation="MDLKHAVRRIAALSAALGAATVVVAAPATADDQVVTVVSEAGRAA
                     ALAHWTPERMRQWVGDEELPPAEKIGREWEGPVPPGVGRLFFTAEPGVDGSCTATVIPS
                     ASKDVAFTAGHCVNGGLDRFDRPIKIVNVVFVPGYDRGAAPHGVFPARSFAWSSTYAGP
                     MSGSDDDAVIALDPVGGRHVADVAGTQDISFEELPSTVDTTMFGYPVSRAAGGEALFSC
                     VRPATREANSVTTTWNTDCDLAGGSSGGPWLRNFDPASGKGTIFSVTSRGTMTEDGVTT
                     DLSGAAFTEPVRRLYERAGEL"
     misc_feature    complement(1554..1567)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.65"
                     /tool="antismash"
     misc_feature    complement(1635..1649)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    1691..1705
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.37"
                     /tool="antismash"
     misc_feature    1691..1706
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.0"
                     /tool="antismash"
     gene            1735..1893
                     /locus_tag="AORI_RS83625"
     CDS             1735..1893
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AORI_RS83625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_158509118.1"
                     /transl_table=11
                     /translation="MPLWTGAAPRPALGGQQRSGGGQAAATRVDVTAPGDVETGDPAIR
                     PTRQGRC"
     gene            2016..2219
                     /locus_tag="AORI_RS42810"
                     /old_locus_tag="AORI_0368"
     CDS             2016..2219
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441988.1"
                     /locus_tag="AORI_RS42810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0368"
                     /product="cold-shock protein"
                     /protein_id="WP_016330817.1"
                     /transl_table=11
                     /translation="MAQGSVKWFNGEKGFGFIAQDDGGPDVFVHYSEIQGTGFKSLDEG
                     QRVEFEIGQGQKGPQAQRVVAI"
     gene            2323..2967
                     /locus_tag="AORI_RS42815"
                     /old_locus_tag="AORI_0369"
     CDS             2323..2967
                     /EC_number="2.3.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="AORI_RS42815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0369"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_016330818.1"
                     /transl_table=11
                     /translation="MRPDTVSRSALEPEQVGRKVRLREVGLRDRRVLMGFDRDMAREAT
                     PLIGGGHRHWASHRSGSAGDDIHFGIETVRGRMLVGSICTIGADPATGKFGYGIGIAPR
                     HQRCGYATDAITVLLAHMFGQRGFRKCEVSVYGGNVASLSLHGGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITAEEFAARPLDALGDLGRRGQHRRPRRGKHWRTPAAVSG"
     gene            complement(2957..3604)
                     /locus_tag="AORI_RS42820"
                     /old_locus_tag="AORI_0370"
     CDS             complement(2957..3604)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="AORI_RS42820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0370"
                     /product="response regulator transcription factor"
                     /protein_id="WP_016330819.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQSLVRTGLRMILDNADDIDVVGEAGDGAEAVALVA
                     DLDPDVVLMDIRMPEMDGVEATAAIAAAHRARVLVLTTFDLDEYVYAALRAGASGFLLK
                     DALAPDLLAGVRVVASGEATLAPTVTRRLLDRVVTGLPAAPPDDRLALLTGRENEVLQQ
                     LARGLSNAEIAELLFLSPGTVKTHVGRILTKLGLRDRVQAVVFAYESGLISR"
     gene            complement(3601..4797)
                     /locus_tag="AORI_RS42825"
                     /old_locus_tag="AORI_0371"
     CDS             complement(3601..4797)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633037.1"
                     /locus_tag="AORI_RS42825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0371"
                     /product="sensor histidine kinase"
                     /protein_id="WP_016330820.1"
                     /transl_table=11
                     /translation="MLSFLRNHPKAVDIGLTVLVGLSTVVSADDPEGFDWWLTSLVALA
                     SLLVRHRSPAITFVTGATVSLLHLAMGNDLRPVDVVALIGLFSVAAWGSRRLSFALLAA
                     SLLVTGAWTIHAADANSREPAPIPPRIIIIDPLAPPEPKDDQVQDWGGFPGIGLSLAVA
                     WLAGLNTRQRRIRLSVLEQRAADLERERDAQAALAVAAERGRISRELHDVVAHALSVVV
                     LQAQGAQAELERRPERTREALDAIVGTGRTALAEIRRLLGALGQDEPDWEPQPGAERLP
                     RLAADVRTAGTPVEFRVEGDPRPLPSTVDLAAYRIVQEALTNVLKHAGPAASVTIVMRY
                     EPDTLEIEVTDDGIAAAEPSGSGHGLEGMRERVNVLGGTFDAGPRPERGFAVRATLPS"
     misc_feature    4938..4953
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            4939..6027
                     /locus_tag="AORI_RS42830"
                     /old_locus_tag="AORI_0372"
     CDS             4939..6027
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030757.1"
                     /locus_tag="AORI_RS42830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0372"
                     /product="hypothetical protein"
                     /protein_id="WP_016330821.1"
                     /transl_table=11
                     /translation="MRRLLVALVALAGLVSLASPAAAAPRLKLPPPTGSHPVGSTDLHL
                     TDSSREDPWVPSGPRELMVSMFYPALVPFGQKRPYLTSAEAKAFLTESGLPDVDPALLS
                     GLRTSARVDAPPLPGKHALVVLSPGFGKPRTTLTGLAEDLASKGFVVALIGHNYESHGT
                     AFPDGHVTGCAACGSDSTLLPPIRSADASFVLDTLTRPSSRWARLIDRTRIGMAGHSIG
                     GYSTPTAMVDDQRIRAGADLDGRLWSPIPASGIDRPFLLLGRESEYTPVGPDTTWAGSW
                     PNLTGWKRWISVATAGHASFTDVGVLGEQLGLSKPGLLGGERGMQLTRAYVSAFFDANL
                     RGGHQPLLDGPVADNPEIKFWN"
     gene            complement(6024..6980)
                     /locus_tag="AORI_RS42835"
                     /old_locus_tag="AORI_0373"
     CDS             complement(6024..6980)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030758.1"
                     /locus_tag="AORI_RS42835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0373"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_016330822.1"
                     /transl_table=11
                     /translation="MTTAQHKIGSGFGARSTAEEVLNGIDLSGRLALVTGGYSGLGLET
                     TRALANAGAHVVVPARRPADAEAALAGIPGTEVGELDLADLASVDAFARRFLGTGRPID
                     ILIANAGIMAAPERRVGPGWESHFAICHLGHHALVNRLWPALKAGGGARVVTVASSGHH
                     SSPMRWDDVQFERGYDRWLAYGQAKTANVLFAVHLDRLGADHGIRAFSLHPGAILTPLQ
                     RHLRPEEMVERGWIDEQGNQADPDFKSPEQGAATQVWAATSPRLDGMGGLYCEDCDVAE
                     IAAEEGEWVGVRPYAIDAGEAERLWTFSADLTGVSLG"
     gene            7037..7429
                     /locus_tag="AORI_RS42840"
                     /old_locus_tag="AORI_0374"
     CDS             7037..7429
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330823.1"
                     /locus_tag="AORI_RS42840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0374"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_016330823.1"
                     /transl_table=11
                     /translation="MTELAIGQVTERTGLSVHALRFYEKEGLLAAPVKRDANGRRVYTE
                     HDVEWLLNCTKFRASGMPLAVIREFAELVRQGPGNEEKRLELLREHQNTVRDRIAELAD
                     CLELISRKVEVYEEHVARGTANELWR"
     misc_feature    complement(7638..7654)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.91"
                     /tool="antismash"
     gene            7798..8784
                     /locus_tag="AORI_RS42845"
                     /old_locus_tag="AORI_0375"
     CDS             7798..8784
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="AORI_RS42845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0375"
                     /product="MCE family protein"
                     /protein_id="WP_016330824.1"
                     /transl_table=11
                     /translation="MRSFGAVDPVKVALAGLTTMALGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLRVDNDVRIAGVKVGKVSEIDLEGDRVLVSFRVKDAWVGDATSASIQIKNVLG
                     QKYLALDPRGEAILDPGDPIPLQRTTAPYDVLEAFRDLSKTVDAIDVGQLAKSFDTISA
                     TFADTPADVRSALDGITKLSGTIASRDRQLRALVANTRQVSQTLVDRDTEVQRLIQDGN
                     ALLRAISTRQQAIKDLLDGSKRLATALDGIIADNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGRWIDGYLCGLVLPTFGPLNEKGCFEK"
     gene            complement(8795..9217)
                     /locus_tag="AORI_RS42850"
                     /old_locus_tag="AORI_0376"
     CDS             complement(8795..9217)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="AORI_RS42850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0376"
                     /product="hypothetical protein"
                     /protein_id="WP_016330825.1"
                     /transl_table=11
                     /translation="MPEETEEKTVDTATDKASGPGRILVAVYAIFALAATSRAAVQIST
                     KFGEAPLAYALSAFAAVVYLLATVALARRGAGWWRIALIACGVELVGVLTVGTFSLFDR
                     EAFPHATVWSVYGQGYLFIPLVLPVIGLFWLRRTKP"
     gene            complement(9210..9575)
                     /locus_tag="AORI_RS42855"
                     /old_locus_tag="AORI_0377"
     CDS             complement(9210..9575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="AORI_RS42855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0377"
                     /product="hypothetical protein"
                     /protein_id="WP_016330826.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICAALVAVWSFVQAARKKLPDNALLAGLAVLEVLL
                     VAQLVIGVVLLIGGGRPGSMATYLAYLIGCLVVLPLGTFWALAERTRASTAILGIACLA
                     IPVMVLRLHEVWAGASA"
     misc_feature    complement(9676..9691)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            10001..12544
                     /gene="lanKC"
                     /locus_tag="AORI_RS42860"
                     /old_locus_tag="AORI_0378"
     CDS             10001..12544
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030764.1"
                     /locus_tag="AORI_RS42860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0378"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_016330827.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1334.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 8e-12, bitscore: 44.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.7e-07, bitscore:
                     29.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQRETGDVADDFASLLPAPEDGWRTGVR
                     GVWRLLHPVARNLPLQGWKIHVSAGLDNAERVLVKVHEHCVEHAVSYKHLRSRTTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLVALSAKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAIRKPDGTLVPDKREPTFSVPDWVTIPEFLAPHLAARKSGGADQ
                     FPYQVKSSLHFSNGGGVYLADRKSDGERVVLKEARPFAGLDRDEVDAVERLRREHEVLE
                     RLKGIDGIPTAYDRFTVWEHHFLAMEYMPGVSLGNWLARNYPLTRRDTTEADIAAYTER
                     ALALVRRVEAMIGEVHGRGIVFGDLHSLNILVDGDDDNVSLIDFEMAADIESGTRPALG
                     APGFRAPRDRNGFEVDEYALAVLKLWIFLPLTTLLELAPAKLRGLADFVQQRFDVPEGY
                     ADSIVAELAPRNLPPLTSSTELDQERPDWALVRKQITEAILASATPERTDRLFPGDIEQ
                     FRVGGACFGYGAAGVLHALKTAGDERHPAHERWLLDSIRRDPPGRPGFYDGSYGIAYVL
                     EELGYRDEATKLLASSSTLVEQTTDHGLEGGLSGIGLTQLHFALARKDNEFGRQALATA
                     VRLAEALEIADPPGDFGRAGLLNGWSGPALLFVRLFERTREEGWLSFADQALERDIEEC
                     VESDDGSLQVRDGETRTLPYAGVGSAGILMVAEELAKHRPDAKALKSLPGLREACRGEF
                     VIHPGLLFGRGGLMTALAMGAEPDQRVRDAIDLHLSRLAWYAVPYKGGLAFPGNQLLRL
                     SMDVVTGGAGVLLALAATLDGKAALPFLSSRTAVR"
     misc_feature    10349..10351
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12584..12727
                     /locus_tag="AORI_RS83200"
                     /old_locus_tag="AORI_0379"
     CDS             12584..12727
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="AORI_RS83200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0379"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_123798255.1"
                     /transl_table=11
                     /translation="MELVLDLQALEAPEVLEGGGGGSHGGASNLSLLASCANSTVSLLT
                     CH"
     CDS_motif       12584..12646
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALEAPEVLEGGGG"
                     /locus_tag="AORI_RS83200_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12647..12727
                     /prepeptide="core"
                     /locus_tag="AORI_RS83200_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="10.40"
                     /molecular_weight="2356.6"
                     /monoisotopic_mass="2355.2"
                     /core_sequence="GSHGGASNLSLLASCANSTVSLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALEAPEVLEGGGG"
                     /leader_location="[12583:12646](+)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.7"
                     /alternative_weights="2428.7"
                     /alternative_weights="2446.7"
                     /alternative_weights="2464.7"
     gene            12958..14625
                     /locus_tag="AORI_RS42865"
                     /old_locus_tag="AORI_0380"
     CDS             12958..14625
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="AORI_RS42865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0380"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_016330829.1"
                     /transl_table=11
                     /translation="MAGSADRLLVKVTALDRPRLIALILSALAGTAAGLLLPGALAAAV
                     DAVVAGRPSLPEVSWLIVLGVTEIAVGLIGGILTARMTASATAWLRRKLADRYLALGTR
                     STFAAGDAISRLTGDCTGAGLVASVVVQLGSTTLISGGAVVLLALMDWRLALVFLGSIP
                     FGLMLARTHLKNTADDVLTYQEVSGELAARMVDAVAGLRTIAASGTADREADRVLRPLP
                     KLSLAGRGMWRTQARMVWRSGLLLPAVELAVLAAAGFGVLEGRLTVGQVLAALGYVALG
                     MGLITQIPLLTTLSRARSCARRITEVLEAPVPEPGDLGVVPGRGTLELRGVTVEGALRD
                     VDLLVRGGRFTAVVGRSGSGKSALVNVLGGLLTPDEGTATLDGRPLEKLRPYELRAVVG
                     FAFERPALLGATIGDAVGYGSWAGEAAVRAACRSAHVDDLIVRLPDGYRTPLRETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     SRADTVVWLEDGRVRAVGAHDGLWRTPAYRAVFTEGAQ"
     gene            14622..16358
                     /locus_tag="AORI_RS42870"
                     /old_locus_tag="AORI_0381"
     CDS             14622..16358
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="AORI_RS42870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0381"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_016330830.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAADRPGTGLRWLAVFGLVAVIGAFGSRLVWHQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVSVIVFACLLPSLARRQRALALADERTAEVAGASLSGMRDIVACGAEPLAALELYD
                     AIDTQAKAAVRVARSGAARTVVIATGGFVPLLLALLVAPGMVQAGVLTAGAALGALVYL
                     ATTMQPALRGLAATASTVVLRLIVALRRLAETAEAEPEADGTAEPDGTAIYVRDLTFSW
                     GAAAQPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLAPQAGRVLLGGVPVREV
                     PAALRHRMVALIPQEAYVFAGTVRDNVGLFAQTAMDGELLAAVRAVGAEPLVTRLGGLD
                     GEMGHGTLSAGEAQLIALARVYASEATVVILDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLSSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFQRA
                     PE"
     gene            complement(16314..16733)
                     /locus_tag="AORI_RS42875"
                     /old_locus_tag="AORI_0382"
     CDS             complement(16314..16733)
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330831.1"
                     /locus_tag="AORI_RS42875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0382"
                     /product="thioesterase family protein"
                     /protein_id="WP_016330831.1"
                     /sec_met_domain="4HBT_2 (E-value: 2.3e-15, bitscore: 56.0,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GGLDIETGAVIGLCVESQCKYHASVSFPGELEVGLRVGHLGRSSVRYEVGMYSKETVIA
                     EGHFVHVFVDRESRRPVPVEGLLRSALEELRTGLG"
     gene            complement(16727..17959)
                     /locus_tag="AORI_RS42880"
                     /old_locus_tag="AORI_0383"
     CDS             complement(16727..17959)
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642937.1"
                     /locus_tag="AORI_RS42880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0383"
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_043847854.1"
                     /sec_met_domain="Fe-ADH (E-value: 5.3e-103, bitscore:
                     343.5, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYGTGSSDEIGYDLTQYGARRVLVLTDPGVAATGWPQRIAEGIE
                     TYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGEWDAFVAVGGGSAIDTAKAVNLLTSND
                     GDLMDYVNAPVGGGRAPSSPLKPLVAVPTTTGTGSESTTVCVLDVLSLRVKSGISHLRM
                     RPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYTEFDRKRPQDRVPYCGSNP
                     LADMFAEQSLRLLSWALPAAVRDGSDLKAREAMALAATFAGLGFGNAGVHIPHANAYPI
                     AGQVREFHPPGYPGDEAMVPHGMAVSLTAPAAFRFTFDAAPDRHIRVARLLAPDYEWPG
                     DLRDHLPAVLGQIMREIGIPNGIGAVGYTESDVDSLVSGTVKQQRLLATAPREASEADL
                     AVILRESVTLW"
     misc_feature    complement(17978..17989)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     misc_feature    18126..18142
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            18131..19792
                     /locus_tag="AORI_RS42885"
                     /old_locus_tag="AORI_0384"
     CDS             18131..19792
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071745.1"
                     /locus_tag="AORI_RS42885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0384"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_267283988.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 6.4e-37, bitscore:
                     125.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-34, bitscore:
                     117.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRYQPGASVAQTAVRILTEAQIHRVYAVVGESFLDLLDALQRERS
                     ITFVSARHDSGAAFMAEAEGKLTEHPAVLLAGRGPSAANLAIGVSTAYQDESPMVVLLE
                     NPPQDPGPTSELPTADLTAMFEPISKWTGRAESPDEVPGLLVEALTRCREGRPGPTVVA
                     VPADFWGVPFDSAKPVASVRPPATGALGRTAEAVAQLVDEARYPVVIVGGRARAARDEL
                     IAVADELALPVYNAFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDE
                     VTTQSFRYPTPSQTLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRNVASPRQRRASAA
                     NAAVHTFMTPPDTSGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPR
                     SQLGPSNAAMGYAVPAAVAAKLAEPRRTVIAMAGDGGALMTGQEIETAVRYRVPVTVLV
                     FQNGVHGPLAVHQARKHGRLSGVTVPITDFASWARGLGAAGYTVDDREELEPIIASALV
                     RQRPCVIDIRTDPDVVTPDIRLTSLLGAARPQQGGQ"
     gene            20053..20223
                     /locus_tag="AORI_RS83795"
     CDS             20053..20223
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="AORI_RS83795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167337757.1"
                     /transl_table=11
                     /translation="MADEAKPQDKSVSGVVPVQFSADAETHDIAVVATNREALRRSPFG
                     TEAPLRAASGE"
     misc_feature    20402..20417
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            20472..20675
                     /locus_tag="AORI_RS42890"
                     /old_locus_tag="AORI_0385"
     CDS             20472..20675
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="AORI_RS42890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0385"
                     /product="cold-shock protein"
                     /protein_id="WP_005163378.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVTVI"
     gene            20944..21816
                     /locus_tag="AORI_RS42895"
                     /old_locus_tag="AORI_0386"
     CDS             20944..21816
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030772.1"
                     /locus_tag="AORI_RS42895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AORI_0386"
                     /product="ATP-NAD kinase"
                     /protein_id="WP_016330834.1"
                     /transl_table=11
                     /translation="MGEAVAGIVANPASERDIQGLRSALRVAGVGRVMVWADAGKIIGT
                     VRRMVDAGASVLICLGNESMMRAAAAACGDVPLLMLPAGGADESTVAGLAAGLVATHQV
                     DTDLVTNRATVLEVVTKARREIALTDVSVCSESRWDPASLTELYCTFAVPDGVGLSSIP
                     GRLCPSPKSTVDGVAVSLGPVDETPYVVQAPIAPGDVRAVGVRGWSVLHAGVRVDLAAG
                     GGSIALDGQPHFVLKPGESAFVELKPDGPWCVDVRAVMAEATRTGLLLGRKPTAALPAP
                     RLADAPFPG"
ORIGIN
        1 tcgcgatcac cgggatcagg agccggttcg tggtgaccgc gggcggcgtg atcctgctga
       61 tcctcggcat gctcccggtg ctcggccgcg tggtggccgc gatcccgtat ccggtgctgg
      121 gcggtgccgg tctcgtgctg ttcggcacgg tcgccgcgtc cggcatcaag actttgtcca
      181 aagtggacta caacgggaac atgaacctgg tgatcgtcgc ggcgtcggtc gggatgggca
      241 tgatccccga tcgcggcgcc ggagttctat caccacttcc cggcgtgggt cggcacgatc
      301 ttccactcgg ggatcagctc cgccgcgctc acggccgtct tgctgaacct gttgttcaac
      361 cacctcaagc ccgccaaggc gggcggtgat ccgtccgtgt tcgcgacggc gaccagggtg
      421 atcgactact ccgacctgaa agccttctcc cgcctcgaaa acggcgacaa gatcgtcgac
      481 ggcaagatcg tggacgccga cggcaacccg gtcgaggtgc gggacgaaga aggcaggcct
      541 gtgtcgtacc ggatcggttc ggagccagac gcgcacgggt gagtgaacaa ccttcccggc
      601 ggccggaacg tccacttcgt atggacttga agcacgcggt tcgccggatc gccgccctgt
      661 cggccgccct cggtgccgcg acggtggtcg tcgccgctcc ggccacggcc gacgaccagg
      721 tcgtcaccgt ggtgagcgag gccggccggg cggcggccct ggcccactgg acgccggagc
      781 ggatgcggca gtgggtgggc gacgaggagc tgccgcccgc cgagaagatc ggccgcgagt
      841 gggaagggcc ggtcccgccg ggcgttggac ggttgttctt caccgccgag cccggcgtcg
      901 acggatcctg cacggcgacg gtgattccca gtgccagcaa ggatgtcgcg ttcaccgccg
      961 ggcactgcgt gaacggggga ctggaccggt tcgaccggcc gatcaagatc gtcaacgtcg
     1021 tgttcgtccc gggttacgac cgcggcgccg caccgcacgg cgtcttcccg gcgcggtctt
     1081 tcgcctggtc cagcacgtac gcggggccga tgagcgggtc ggacgacgac gcggtgatcg
     1141 cgctggaccc ggtcgggggc cgtcacgtcg cggacgtcgc gggcacccag gacatctcgt
     1201 tcgaggagct gccgtccact gtggacacga ccatgttcgg ctatcccgtg tcgcgggcgg
     1261 cgggtggcga ggcgttgttc tcctgcgtcc ggcccgccac gcgcgaggcg aactcggtca
     1321 ccacgacgtg gaacaccgat tgcgatctgg ccggcggctc cagtggcggc ccgtggctgc
     1381 ggaacttcga ccccgccagt ggcaagggca cgatcttcag cgtcacgagc cgggggacga
     1441 tgaccgagga cggcgtgacc acggacctga gcggcgccgc tttcaccgag cccgtgcgga
     1501 ggctgtacga gcgggcgggt gaactctgaa cggcttcgtg ttcgtcgtga gcggcaattc
     1561 gggtgccagt ggaaggtggc ggtggacggg tgcgcccagt aggcctgtcg ctgtccacga
     1621 gggacacgac ccccatcgaa gtgtctgatt tgggcgcttt cgcgggggtc gtgagtggca
     1681 aggatcgttc taaccctctt tttcactcac gacccccact ggagtcgccg tgcagtgccc
     1741 ctgtggacag gcgcggctcc gcggcccgcg ctcggcgggc agcagcggag cggcggcggg
     1801 caggcggccg ccacgcgggt ggacgtcacc gctcccggcg acgtcgaaac cggcgatccg
     1861 gcgatccggc cgactcgcca aggtcgatgt tgacctgggg aaatgacccg gttcgggacg
     1921 gcagcgtgtg cgaacgggca agacctgcga caatggacag cgagatcggg gcatcgaatg
     1981 ggctcagact cgctatgaag agcaggtaga aaagtatggc tcagggcagc gttaagtggt
     2041 tcaacggcga aaagggcttc ggcttcatcg ctcaggacga cggcggaccg gacgttttcg
     2101 tgcactactc cgagattcag ggcaccggct tcaagtccct ggacgagggt cagcgcgtcg
     2161 agttcgaaat cggccaaggt cagaagggcc cgcaggccca gcgcgtcgtc gccatctgac
     2221 tttctctcac gccgaaggcc tccatccgta ccgggtgggg gccttcgggc gtttcgggta
     2281 ccgatatcgt cgaggcatgc ttgtgatcgt tcgtgagcac acgtgcggcc ggacacggtg
     2341 agccgctccg ccctggagcc cgagcaggtc gggcggaagg tgcggttgcg cgaggtcggc
     2401 ctccgggacc gccgcgtcct gatgggcttc gaccgggaca tggcccgcga ggcgacgccg
     2461 ctgatcggcg gcgggcaccg gcattgggct tcgcaccgtt cggggtccgc gggcgacgac
     2521 atccacttcg gcatcgagac ggtgcgcggc cgcatgctgg tcggctcgat ctgcaccatc
     2581 ggcgccgacc cggcgaccgg caagttcggc tacggcatcg ggatcgcccc gcgtcaccag
     2641 cgctgcggct acgccacgga cgccatcacc gtcctgctgg cgcatatgtt cgggcagcgc
     2701 ggcttccgca aatgcgaggt cagcgtgtac ggcggcaacg tcgcgtcgct ctcgctgcac
     2761 ggcggcctcg gcttccgcga ggaaggcagg ctccgggaca ccgaggtggt gcgcggcgag
     2821 atcaagtacc tggtgcggat gggcatcacg gccgaggagt tcgccgcccg gccgctggac
     2881 gcgctcggcg acctcggcag gcgtggccag caccgccggc cccgtcgcgg caagcactgg
     2941 cgtacgcccg ccgcggtcag cggctgatca gcccggattc gtaggcgaac acgaccgcct
     3001 ggacgcggtc gcggaggccg agtttcgtga ggatgcggcc gacgtgcgtc ttcaccgtgc
     3061 ccggtgagag gaacagcagc tcggcgatct cggcgttcga cagtccccgg gccagctgct
     3121 gcagcacctc gttttcccgc ccggtgagca gggcgagccg gtcgtccggc ggcgccgcgg
     3181 gcaggccggt gacgacgcgg tcgagcagcc gccgggtgac ggtgggtgcg agggtggcct
     3241 cgccggaggc gaccacgcgg acgccggcga gcagatccgg cgccagcgcg tccttgagca
     3301 ggaagccgct ggccccggcc cggagcgcgg cgtagacgta ctcgtccagg tcgaacgtgg
     3361 tcagcaccag gacccgggca cgatgggccg cggcgatcgc ggcggtggcc tcgacaccgt
     3421 ccatctcggg catccggatg tccatgagca ccacgtccgg gtcgaggtcc gccaccagcg
     3481 cgacggcctc cgcgccgtcg cccgcctcgc cgacgacgtc gatgtcgtcc gcgttgtcca
     3541 ggatcatccg caggccggtg cgcacgagcg actggtcgtc ggcgatgacc acccggatcg
     3601 tcatgacggc agggtcgcgc ggacggcgaa gccgcgctcc ggacgcggtc ccgcgtcgaa
     3661 ggtgccgccc aggacgttca cccgttcccg catgccctcg aggccgtgcc cggagccgga
     3721 cggctctgcc gccgcgatgc cgtcgtcggt cacttcgatc tccagcgtgt cgggctcata
     3781 ccgcatcacg atagtcaccg acgccgccgg gccggcgtgt ttcagcacgt tcgtcagcgc
     3841 ctcctgcacg atgcggtagg ccgcgaggtc cactgtggac ggaagtggcc ggggatctcc
     3901 ttcgacccgg aactcgaccg gcgtgcccgc ggtacggacg tcggccgcca gtcgcggcag
     3961 gcgttcggcg ccgggctggg gctcccaatc cggctcgtcc tggccgagcg cgccgagcag
     4021 ccgccggatc tcggccaacg cggtccgccc ggtgccgacg atggcgtcca gcgcctcccg
     4081 cgtccgctcc ggccgccgct ccagttcggc ttgggcgccc tgtgcctgca acaccaccac
     4141 cgaaagcgcg tgcgcgacga cgtcgtgcag ctcgcggctg atgcggccgc gttcggcggc
     4201 cacggccagc gcggcctggg cgtcccgctc gcgttcgagg tcggcggccc gctgttccag
     4261 caccgaaagg cggatccggc gctgccgcgt gttcagcccg gcgagccagg ccaccgccag
     4321 cgacaatccg atgcccggaa aaccgcccca gtcctgcacc tggtcgtcct tcggctcggg
     4381 aggcgccagc ggatcgatga tgatgatccg cggcggtatc ggagccggtt cccgcgaatt
     4441 cgcgtcggcg gcgtggatcg tccacgcacc ggtgaccagc aggctcgccg ccagcagcgc
     4501 gaacgaaagc cgtcgagaac cccaagccgc gaccgagaag aggccgatca acgccacgac
     4561 gtcgaccggg cggagatcgt tgcccatggc cagatgcagg agtgagacgg tcgcgccggt
     4621 cacgaaggtg atcgcgggac tgcggtgccg gacgagcagg gaagccaacg ccaccaagga
     4681 ggtcagccac cagtcgaagc cctccggatc atcggccgag accacagtgg acagtccgac
     4741 gagcacggtc agcccgatgt ccacggcttt cgggtggttc ctgaggaagg agagcaccgg
     4801 ccgagcgtaa tcccggaccg gcgcctcgcg gatccctctc gcggcagaca tcgggatacg
     4861 accagcggca gacgcgcgaa tacggcaccg ggtcccaggc tggacgccag gaagatcccc
     4921 gacagaaacg gaatcctcat gagaaggctt ctcgtcgcgc tggtcgccct cgccggcctg
     4981 gtgtcgttgg cgagcccggc cgcggcggct ccacgactca agttgccgcc gccgaccggt
     5041 tcgcatcccg tcggctccac cgatctgcac ctgaccgact cttcgcgcga ggacccctgg
     5101 gtgccgtccg ggccgcgcga gctgatggtg tcgatgttct atcccgcgtt ggtgcctttc
     5161 ggccagaaac ggccctacct cacctcggcc gaggccaagg cgttcttgac cgaatcgggg
     5221 cttcccgacg tcgaccccgc gctgctctcc gggctccgta ccagcgccag ggtcgacgcc
     5281 ccgccgctgc cggggaagca cgcgctcgtc gtcctgtcgc cgggattcgg caaaccgcgc
     5341 accacgctca ccgggctggc cgaagacctg gcgagcaagg gtttcgtggt cgcgctgatc
     5401 ggccacaatt acgagtccca cggcaccgcc ttccccgacg gacacgtcac cggatgcgcc
     5461 gcctgcgggt cggactccac gttgctcccg ccgatccgct cggcggacgc ctccttcgtc
     5521 ctcgacaccc tgaccaggcc ttcgtcgcgc tgggcccggc tgatcgaccg gacgcggatc
     5581 gggatggccg ggcattccat cggcgggtac agcacgccga ccgcgatggt cgacgaccag
     5641 cggatccggg cgggcgccga cctggacggc aggctgtggt cgccgatccc cgcgtccggc
     5701 atcgaccggc cgttcctgct gctcggccgc gaaagcgagt acaccccggt cggcccggac
     5761 accacctggg cgggcagctg gccgaacctc accggctgga agcgctggat cagcgtcgcg
     5821 acggccgggc acgcgtcctt caccgacgtc ggcgtgctcg gtgagcaact cgggctgagc
     5881 aagcccggtc tgctcggtgg cgagcgtgga atgcagctga ccagggcgta tgtctcggcg
     5941 ttcttcgacg cgaacctgcg cggcgggcat cagccgctgc tcgacgggcc ggtggcggac
     6001 aaccccgaga tcaagttctg gaactagccg agggagaccc cggtgaggtc ggcggagaac
     6061 gtccagagcc gctcggcctc accggcgtcg atggcgtagg ggcgcacgcc gacccactcg
     6121 ccctcttcgg cggcgatctc ggcgacgtcg cagtcctcgc agtagagccc gcccatcccg
     6181 tcgagccgcg gtgacgtcgc cgcccagacc tgggtggccg cgccctgctc cggcgatttg
     6241 aagtccgggt cggcctggtt cccctgctcg tcgatccagc cgcgctcgac catttcctcc
     6301 ggccgcagat ggcgctgcag gggagtgagg atggcgcccg gatgcaggct gaacgcgcgg
     6361 atcccgtggt cggcgccgag cctgtccagg tgcaccgcga acagcacgtt cgccgtcttg
     6421 gcctggccgt aggcgagcca gcggtcgtag ccgcgctcga attggacgtc gtcccagcgc
     6481 atcggcgacg agtgatggcc ggacgaggcc accgtgacga cgcgggcgcc gccgccggcc
     6541 ttcagcgcgg gccaaaggcg gttcaccagg gcgtggtggc cgaggtggca gatcgcgaaa
     6601 tgcgactccc agccggggcc gacccgccgt tccggcgcgg ccatgatccc ggcgttcgcg
     6661 atgaggatgt cgatcggacg gccggtgccg aggaagcggc gggcgaaggc gtcgacgctc
     6721 gccaggtcgg cgaggtcgag ctcgccgacc tcggtgccgg ggatcccggc gagggcggcc
     6781 tcggcatcgg ccggacggcg cgccgggacg accacgtgcg cgccggcgtt cgccagtgcc
     6841 cgcgtggttt ccaggcccag ccccgaatac ccgccggtga cgagggcgag cctgccggag
     6901 aggtcgatgc cgttcagtac ttcttcggcg gtgctgcgcg ctccgaagcc ggagccgatc
     6961 ttgtgttgtg cggtggtcat ggggcggacg ctaagagcta gagggccctc taggtcaagg
     7021 cgctatcgtc agcctggtga cggaactcgc gatcggccag gtcaccgagc ggacgggcct
     7081 cagcgtgcac gcgcttcgct tctacgagaa ggaagggctg ctcgcggcgc cggtgaaacg
     7141 ggacgcgaac ggccgccgcg tgtacaccga acacgacgtc gaatggctgc tgaactgcac
     7201 gaagttccgg gcgtccggaa tgccgctcgc cgtcatccgc gaattcgccg aactcgtccg
     7261 ccaagggccg ggaaacgagg aaaagcggct cgaactgctg cgggaacacc agaacaccgt
     7321 ccgcgaccgg atagccgagc tggccgattg cctggaactg atcagccgga aggtcgaggt
     7381 ctacgaggag cacgtcgcgc gggggaccgc gaacgagctt tggcgctagc ggtcacgggt
     7441 tcaccaccca gaagacgatc ctgctgaaga cgttcaaacg ggacggcgat caacatcgcc
     7501 gtcgtaggcg atcacgcgta catccggacg tatgacgcgg catggaaggc caagcggatg
     7561 cgcaacgatt cgcgggtcga gatcgcgcca tcgatgttcc gtggcgtcta cacggcttcc
     7621 tcgccccgct cttccaccgg ttgaagaggt acaagacgct ccactacgaa gtccgtctcg
     7681 acacccctta gagtccatag tggacggacg ttgccacccg atcggtgcaa cgtttcgcct
     7741 ggcgatgggc aggggcggcc cttaagcttt gccgctcgtg acctgcgagg tgagacgatg
     7801 aggtccttcg gcgcggtgga tccggtcaag gtggcgctcg ccgggctcac cacgatggcc
     7861 ctcggcatgg cggcggcgct caacgccgac gccctgccgg tgatcggcgg cggcaccacg
     7921 tattccgccg aattctccga cgcgggcgga ctgcgcgttg acaacgacgt ccggatcgcc
     7981 ggggtgaagg tcggcaaggt atccgagatc gacctcgaag gcgatcgcgt gctcgtctcc
     8041 ttccgggtga aggacgcctg ggtcggcgac gccacgagcg cgtccattca gatcaagaac
     8101 gtcctgggac agaagtactt ggcgctcgac ccgcgcggcg aagcgatcct cgatccggga
     8161 gacccgatcc cgctgcagcg gaccaccgcg ccatacgacg tccttgaagc gtttcgcgat
     8221 ttgtcgaaaa ccgtcgacgc catcgacgtc ggtcaattgg cgaaaagctt cgacacgatt
     8281 tcggcgactt tcgccgatac gcctgccgac gtccgctccg cgctcgacgg gatcacgaag
     8341 ctctccggca ccatcgcctc ccgggaccgg cagctccggg cgctcgtcgc gaacacgcgt
     8401 caggtgtcgc agaccctcgt cgaccgcgac accgaggtcc agcggcttat ccaggacggc
     8461 aacgcgctgc tgcgcgcgat ctccacccgc cagcaggcga tcaaggacct gctcgacggc
     8521 tcgaaacggc tcgcgaccgc gctcgacggc atcatcgccg acaacgacgg gcaactgggc
     8581 ccggtgctcg aacaactcga ccggctgacg tcgatgcttc agcggaatca agactcgctg
     8641 gccaagggga tcgccgcgtt cgctccggcg atccgggtgc tcaccaacgt cgcgggcaac
     8701 ggccgctgga tcgacggcta cctgtgcggg ctggtcctgc ccacgttcgg cccgctcaac
     8761 gaaaagggct gcttcgagaa gtgagcggcc tccgtcaggg cttcgtccgg cgcaaccaga
     8821 acaacccgat caccggcagc accagcggga tgaagaggta gccctgcccg tacaccgacc
     8881 acacggtggc gtgcgggaag gcctcgcggt cgaagaggct gaacgtgccg acggtcagca
     8941 cgccgaccag ttcgacgccg caggcgatca gcgcgatccg ccaccagccc gcgccgcggc
     9001 gggccagcgc cacggtggcc agcaggtaca cgacggcggc gaacgcggag agggcgtacg
     9061 ccagcggggc ttcgccgaat ttggtgctga tctgcacggc ggcgcgtgag gtcgccgcca
     9121 gcgcgaagat cgcgtacacg gcgaccagga tccgtcccgg gccggaggcc ttgtccgtcg
     9181 cggtgtccac cgtcttctcc tcggtttctt caggcacttg cgcccgccca gacctcgtgc
     9241 agccggagca ccatcaccgg gatggcgagg caggcgatgc cgaggatcgc ggtgctcgcc
     9301 cgggtgcgct cggccagtgc ccagaaggtc ccgagcggga gcacgaccag gcagccgatc
     9361 agataggcga gataggtggc catgctgccg gggcggccgc cgccgatcag caggacgacc
     9421 ccgatcacga gctgggccac caggagtact tcgagtacgg cgaggccggc gagcagcgcg
     9481 ttgtccggca gcttcttgcg tgccgcctgg acgaaactcc acaccgcgac cagcgccgcg
     9541 cagatcgcga cggtcaccgc gaaccctgtg atcacgtcgg cctccttacc cgctccaccg
     9601 gcgacaacgt acctccgggc ggatcaccgc cgacgggcga ccggtgggcc gcgtggcggg
     9661 cgccacgggc cgggcagtgg tccagacctc gggtgaatag atcacgaaac gcggcggatt
     9721 ggcgcactgt caattccatc gtgcgttatt gcgttcagcg cctcgacctg ggattacggc
     9781 gccagcgcgt tcctgttaca caccgaccgg gtggttggaa tccgagttga tctcacgctg
     9841 ggtaccccta ccattcggta gttttcgaat tcacgtccct gaacagccca tccgaacccc
     9901 cgatatggcg gattggccgt tcggggtccg gcaggtggaa tattctgcat cgcgatggtg
     9961 cacatggccc atccgattgg tgccaaggag ggggcgctcg atggacgtcc ggtacgaagc
    10021 gtattgcttc gccgatccac tgttcttcga tgagcagcgg gaaaccgggg acgtcgccga
    10081 cgatttcgcc tccctgttgc ccgctcccga agacggctgg cgcaccgggg tgcgcggagt
    10141 gtggcggttg ctgcaccctg ttgctcgaaa ccttcccttg cagggctgga aaatccacgt
    10201 ttcggcaggt ttggacaacg ccgaacgggt gctcgtgaag gtgcacgagc attgtgtcga
    10261 gcacgccgtg tcctacaagc atctgcgttc gcggaccacc ctgctggcca ggaattccaa
    10321 atacgcgccg cgtgacggaa gcggtaagtt actgactctt tatccggctg acaacaacga
    10381 gctcgagcgt gttctagtcg cgttgtcggc gaagctcgac ggcgaacccg gggcatacat
    10441 tctcagtgat cttcggtatg gtgccgggcc gctctacgtc cgctacggcg gattcgccga
    10501 gcaatgggtc gaactcgacg gcaagcgggt cctcgccata cgcaaaccgg atgggacgct
    10561 ggtccccgac aagcgcgaac ccaccttctc cgtgcccgac tgggtgacga ttcccgagtt
    10621 cctcgcgcct catctcgccg ctcgcaagag cggcggtgcg gatcagttcc cctatcaggt
    10681 gaaaagttct ctgcacttct ccaacggcgg cggcgtgtac ctcgccgacc ggaagtccga
    10741 cggcgaacgc gtggtcctca aggaggccag gccgttcgcc ggcctggacc gcgacgaggt
    10801 cgacgccgtc gaacgtctcc gccgtgagca cgaggtgctg gagcggctga agggcatcga
    10861 cggcatcccc accgcctacg accgcttcac cgtctgggag caccactttc tggcgatgga
    10921 gtacatgccc ggcgtctcgc tcggcaactg gctcgcccgc aactacccgc tcacccggcg
    10981 cgacaccacc gaggccgaca tcgccgcgta taccgaacgc gcgctggcgc tggtccggcg
    11041 ggtggaggcg atgatcggcg aggtgcacgg ccgcgggatc gtcttcggcg acctccattc
    11101 gttgaacatc ctggtggacg gggacgacga caacgtctca ctgatcgact tcgagatggc
    11161 agccgacatc gaaagcggca cccggcccgc gctcggcgcg cccggcttcc gtgccccgag
    11221 ggaccggaac gggttcgagg tcgacgagta cgcgctcgcc gtcctgaagc tgtggatctt
    11281 cttgccgctc acgacgctcc tggagctcgc cccggcgaag ctgcgcgggc tcgcggactt
    11341 cgtccagcag cgcttcgacg tcccggaggg ctacgccgac tcgatcgtcg cggagctcgc
    11401 accccggaac ctgccgccgc tcacgagcag caccgagctg gaccaggaac gaccggactg
    11461 ggcactggtc cgcaagcaga tcaccgaggc gatcctcgcc agcgcgaccc ccgagcgcac
    11521 cgaccggctc ttccccggcg acatcgaaca gttccgcgtc ggcggagcgt gcttcggcta
    11581 cggcgcggcc ggcgtcctcc acgccctgaa aaccgccggc gacgagcggc atcccgcgca
    11641 cgaacgctgg ctgctggact cgatccgccg cgatccgccc ggacggccgg ggttctacga
    11701 cggctcgtac ggaatcgcgt acgtcctcga agagctcggg taccgggacg aggccaccaa
    11761 gcttttggcg tcgtcgtcga cgctggtcga gcagaccacc gaccacggtc tggaaggcgg
    11821 cttgtccggt atcgggctca cccagctgca cttcgcgttg gcccgcaagg acaacgagtt
    11881 cggcaggcag gcgctcgcca ccgccgtccg gctcgcggaa gcgctcgaga tcgccgaccc
    11941 gcccggcgac ttcggccgtg ccggcctgct caacggctgg tccggtccgg cgctgctgtt
    12001 cgtgcggctg ttcgaacgca cccgcgaaga gggctggctg tccttcgccg accaggcgct
    12061 ggagcgggac atcgaggaat gcgtcgagtc cgatgacggc tcgctgcagg tccgcgacgg
    12121 cgagacccgg acgttgccgt acgcgggtgt cggcagcgcc gggatcctca tggtcgccga
    12181 ggaactcgcg aagcaccgtc cggacgcgaa ggcgctgaag agccttcccg gcctgcgtga
    12241 agcgtgccgc ggcgagttcg tcatccaccc cggactgttg ttcggccgag gcgggctgat
    12301 gaccgcgctg gccatgggcg ccgaaccgga ccagcgcgtc cgcgacgcca tcgacctgca
    12361 tctttcccgg ctggcctggt acgcggtgcc gtacaagggc gggctggcgt tccccggcaa
    12421 ccagctgctg cggctgtcga tggacgtcgt caccggcggc gcgggcgtcc tgctcgcctt
    12481 ggccgccacc ctggacggga aggccgcgct gcctttcctg tcctcccgaa ctgccgtccg
    12541 atgaggacgg cggaccaaga ggtaactagt gaaagggaac accatggaac tggttctcga
    12601 cctgcaggcc ctggaagccc ccgaggttct cgagggtggc ggcggtggca gccacggcgg
    12661 cgcgagcaac ctcagcctgc tggcctcctg cgcgaacagc accgtcagcc tgctgacctg
    12721 ccactgagtc acggctgagc actgaaggcg cgggagcggc acaggccaag tgcgccgctc
    12781 ccgcgccttc attttgcctt ccggttcatc tcgttgggat cacggtgtcc gccggcgcgg
    12841 gtcgggtggg tcgtgagtgg cgattcgggt tagaacccga atcgccactc acgacccacc
    12901 ggaccgacct gccggcccct accgggaagc gcccctgaac caagactaag gagtggcatg
    12961 gcgggttccg ccgatcggtt gctggtcaag gtgaccgcgc tggatcgccc ccgcctgatc
    13021 gcgctgatcc tcagcgcgct cgccgggacg gcggcgggac tgctcctgcc cggcgcgctc
    13081 gccgcggcgg tcgacgccgt cgtggccgga cggcccagcc tgcccgaggt ctcctggctg
    13141 atcgtcctcg gtgtcaccga gatcgccgtc ggcctgatcg gcggcatcct caccgcgcgg
    13201 atgaccgcgt ccgccaccgc ctggctgcgc cgcaaactcg ccgaccgcta cctcgcgctc
    13261 ggcacccggt cgactttcgc cgccggcgac gcgatcagca ggctcaccgg tgactgcacc
    13321 ggcgctggac tggtcgcctc ggtcgtcgtc cagctcgggt ccaccaccct gatctccggc
    13381 ggggccgtcg tcctgctcgc gctgatggac tggcggctcg cgctggtctt cctcggcagc
    13441 atcccgttcg gcctgatgct cgcacgcacc catctgaaga acaccgccga cgacgtcctc
    13501 acctatcaag aggtgtccgg cgaactcgcg gcgaggatgg tcgacgccgt cgccgggctc
    13561 cgcacgatcg ccgcgtccgg caccgccgac cgcgaggccg accgtgtgct gcggccgctg
    13621 ccgaagctga gcctcgccgg ccgtgggatg tggcgcacgc aggcccggat ggtgtggcgc
    13681 tccgggctgc tgctgcccgc ggtcgaactc gcggtgctcg ccgccgccgg tttcggggtg
    13741 ctggaaggca ggctgaccgt cggccaggtt ctcgcggcgc tcggctacgt cgcgctcggc
    13801 atggggctga tcacgcagat tcccttgctc accacacttt cccgcgcccg gtcgtgtgcg
    13861 cggcggatca ccgaggtgct ggaggcgccg gtccccgaac cgggtgacct cggcgtcgtc
    13921 cccgggcggg gcacgctcga actgcgcggc gtcaccgtcg aaggcgcgtt gcgcgacgtc
    13981 gacctgctcg tccgtggcgg ccggttcacc gcggtcgtcg ggcggtccgg ttcggggaag
    14041 tccgcgctgg tcaacgtcct cggcgggctg ctgaccccgg acgaggggac ggcgacgctc
    14101 gacggccgcc cgctggagaa gctgcggccg tacgaactcc gcgcggtggt cgggttcgcc
    14161 ttcgaacgtc ccgcgctgct cggcgcgacg atcggcgacg ccgtcggcta cggctcgtgg
    14221 gccggtgagg ccgccgtgcg tgccgcctgc cggtccgcgc atgtcgacga cctgatcgtc
    14281 cggctgccgg acggctaccg gacgccgctc agggaaaccc cgctctccgg cggggaggcg
    14341 cagcggatcg ggctggcccg cgcgatcgcg cacgcgccgc gagtgctcat ccttgacgac
    14401 gccaccgcca gcctcgacac ggtcaccgaa gccgccgtcg aggaggcgat cgaacgcacg
    14461 ctgcccggcc ggaccagggt ggtggtgacg catcgcgcgg ccaccgcgtc gcgggcggac
    14521 acggtggtgt ggctggaaga cggccgggtc cgggcggtcg gcgcccatga cggactgtgg
    14581 cggactccgg cttaccgggc cgtcttcacc gagggcgccc aatgagcgtc tgggggctct
    14641 accgctcggc gctggccggg cagtggcgcg gcgggctggt gctgctggcc tgctccgtac
    14701 tggagagcgc gcccgcgttc ttgtccggtc gcctggtcga actcgcggtt gacgaggggt
    14761 ttgccgcgga tcggccaggc accggactgc gttggctcgc ggtcttcggg ctggtcgccg
    14821 tgatcggcgc gttcggttcg cggctggtgt ggcatcagct cggcaaggtc gtcgagccgt
    14881 tgcgcgacgc gctggtgacc gccgtcgtgc gcggggtcct gcacgatccg gcgccgccgc
    14941 gcaatcagcc ggacgccagc ggcgtcgccc gcatcaccca gcatgtcgag gtggtgcgcg
    15001 acgccacggc cgggcttttg gtgcaggcgc gcgggatgat cgtgacgacg gtggcggcgc
    15061 tggccgggtt gttcaccgtc gccggttcgc tcgcgttgat cgtggcgatc ccggtggtgg
    15121 tctcggtcat cgtgttcgcc tgcctgctcc cgtcgctggc gcggcgtcag cgcgcgctcg
    15181 cgctggccga cgagcggacc gccgaggtcg cgggcgcgtc gttgtccggt atgcgtgaca
    15241 tcgtcgcgtg cggcgccgaa ccccttgccg cgctggagct ttacgacgcc atcgacacgc
    15301 aggccaaggc ggccgtgcgg gtggcgcggt ccggggcggc ccgcacggtg gtgatcgcga
    15361 ccggcggttt cgtgccgctg ctcctggcgt tgctggtggc gccgggcatg gtccaggccg
    15421 gggtgctcac cgccggtgcc gcgctcggcg cgctcgtcta cctggcgacg acgatgcagc
    15481 ccgcgttgcg agggctggcc gcgacggcga gcaccgtggt gctgcggctg atcgtcgccc
    15541 tgcggcggct cgccgagacc gccgaggccg agccggaggc cgacggcacg gccgaacccg
    15601 acgggaccgc gatctacgtg cgcgacctga ccttcagctg gggcgcggcc gcgcaaccgg
    15661 tggtgcgcgg gctcgacctg catctgcggc ccggcgagcg gctcgcggtg gtggggccga
    15721 gcggaatcgg caagtcgacc ttggccgggc tgctgaccgg catgctcgcc ccgcaggccg
    15781 gccgggtgct gctcggcggg gtgccggtcc gggaggtccc ggcggctctg cggcaccgga
    15841 tggtcgcgct catcccgcag gaggcgtacg tcttcgcggg gaccgtgcgg gacaacgtcg
    15901 gcctgttcgc gcagaccgcg atggacggcg aactgctggc tgcggtgcgg gccgtcggcg
    15961 cggaaccgct ggtcacgagg ctgggcgggc tcgacggcga gatggggcac ggcacgctgt
    16021 ccgccggtga ggcgcagttg atcgcgctcg cgcgggtgta cgcgagcgaa gcgaccgtcg
    16081 tcatcctcga cgaggcgacg tcgcatctcg acccgcccgc cgaagcccgt gcggaacggg
    16141 cgttcgccga gcggggcggg gtgctggtgg tgatcgcgca tcggctgtcg tcggcgttgc
    16201 gcgcggaccg ggtcctggtg atggacggca aggagaccgc cctgggcacc cacctcgaac
    16261 tcatggaccg gtccacgcgc tacgcccagc tcatgcacgc gtggtcgccg cggctacccc
    16321 agcccagtgc gcagttcttc cagcgcgctc ctgagtagac cctcgacagg gaccgggcgc
    16381 cgggattcgc gatcgacgaa gacgtgcacg aaatgcccct ccgcgatcac cgtctccttc
    16441 gagtacatcc cgacctcgta gcggacactg gaccggccga gatggcccac ccgcaggccg
    16501 acttcgagtt ctcccgggaa cgacaccgaa gcgtggtatt tgcactgcga ttccacgcac
    16561 aacccgatga ccgcgccggt ctcgatgtcg aggccgccgc gttcgatcag ccaggtgttg
    16621 atcacggtgt ccatcaccga atagtggacg acgttgttga cgtgtccgta gacgtcgttg
    16681 tccttccacc gcaacggaac cgtctgccag tgcggatact cggcgttcac cacagcgtca
    16741 ccgactcccg caggatcacc gcgaggtccg cttcggacgc ctcgcgcggc gccgtcgcca
    16801 gcagccgttg ttgtttcacc gtgccggaaa ccagcgagtc cacatcggac tcggtgtagc
    16861 cgacggcgcc gatcccgttg gggatcccga tctcccgcat gatctgcccg agcaccgcgg
    16921 gcaggtggtc ccgcagatcg cccggccatt cgtagtccgg cgcgagcagc cgtgccaccc
    16981 ggatgtgccg gtccggcgcg gcgtcgaagg tgaaccggaa cgccgccggc gccgtcagcg
    17041 agacggccat cccgtgaggc accatcgctt cgtcacccgg ataccccggg ggatggaatt
    17101 cccgcacctg accggcgatc ggatacgcgt tggcgtgcgg gatgtgcacc ccggcgttgc
    17161 cgaaaccgag cccggcgaac gtcgccgcga gcgccatcgc ctcgcgcgcc ttcaggtcgg
    17221 agccgtcgcg cacggccgcg ggcaacgccc acgacagcag ccgcagcgac tgctcggcga
    17281 acatgtcggc cagcggattc gagccacagt aaggaacccg gtcctgcggc cgcttccggt
    17341 cgaactcggt gtacggcttg gccgtgtagc tttccgcggc gtggcaaagg atgtccatcc
    17401 cgctggcggc ggtcacctcg ggcggctgcg agaccgtcag cctcgggtcg accaccgcga
    17461 ggctcggtcg catccggaga tggctgatgc cgctcttcac ccgcagtgac aacacgtcca
    17521 gcacgcagac cgtggtgctc tccgagcccg tcccggtggt ggtcggcacc gcgaccagcg
    17581 gtttcagcgg cgagctcggg gcgcggccgc cgccgaccgg cgcgttgacg taatccatca
    17641 ggtcgccgtc gttgctggtc aacaggttca ccgctttggc ggtgtcgatg gccgacccgc
    17701 cacccacggc gacgaaggcg tcccattcgc cctgtccgcg ggcgaagtcg acggccttcc
    17761 gcatgctgac gtcggtcggc tcgacgtgga cgccgtcgaa gacgacggct tcgatgccat
    17821 aggtttcgat gccttcggcg atccgttgtg gccagcccgt cgcggcgaca cccgggtcgg
    17881 tcaggacgag cacccgacgg gcgccgtact gggtgaggtc gtagccgatc tcatcgctcg
    17941 acccggtgcc gtacttcaag gcaggcgccc cgtaagtgaa aacagtttca cgtccggcgg
    18001 tggctgaggt cacgttttcg tgctcccttg ctcgaacacg ttccgaatat cggacattcc
    18061 gccgctccgg ggttgccgga atcggaagat cgcttgacgg caccgatcac cgcccgccta
    18121 agctcttctc attagatacc aaccgggagc gtccgtcgcc cagacggccg tgcggatcct
    18181 gaccgaggcg cagatccacc gcgtgtacgc ggtggtgggt gagtccttcc tggatctgct
    18241 cgacgcgctg caacgcgagc gctcgatcac cttcgtctcg gcgaggcacg actccggcgc
    18301 cgccttcatg gccgaggccg aaggcaagct caccgagcac cccgcggtcc tgctcgccgg
    18361 ccgcggcccg agcgcggcga acctcgcgat cggcgtctcc acggcgtacc aggacgaaag
    18421 cccgatggtc gtcctcctgg agaacccgcc gcaggatccc ggcccgacga gcgagctgcc
    18481 caccgcggac ctgaccgcga tgttcgagcc gatctcgaag tggaccggcc gcgcggagtc
    18541 gcccgacgag gtgcccggtc tgctggtcga ggcgctgacc cgctgccgcg aggggcggcc
    18601 ggggcccacc gtcgtcgccg tccccgccga tttctggggt gtcccgttcg attcggcgaa
    18661 accggtcgcc tccgtgcggc cgcccgccac cggcgcgctg ggccggaccg ccgaggcggt
    18721 cgcgcagctg gtcgacgagg cccgctaccc ggtggtgatc gtcggcggcc gggcccgggc
    18781 ggcgcgcgac gagctgatcg ccgtcgccga cgagctcgcg ttgccggtgt acaacgcgtt
    18841 ccgccgccag gacgccttcc ccgagaacca cgcgcgctac gccggccatc tcggcatcgg
    18901 catccccgcg cggcagctcg acgcgctgga gcgcgcggat ctcgtgctcg cgctgggcac
    18961 gcagctcgac gaggtcacca cccagtcctt tcgctacccg acgccgtcgc agacgctggt
    19021 gctggtcggc accgggatcg agcccgcccg ccgcggcggg ctgaccttcc gggtcgactc
    19081 cgaggtcgag cccttcctgc gtgaactgcg caatgtcgcc tcgccccggc agcggcgcgc
    19141 gtcggccgcg aacgccgcgg tgcacacctt catgacgccg cccgacacga gcggcgccac
    19201 ccgcgtccac cccgccgacg tcatccgcgc ggtgcgcaaa ctcgcgcccg aagacgcgat
    19261 cgtgaccagc gacgcgggca acttcgccca gttcatgcac cgctactggt gtttcaccgc
    19321 gccgcgcagc cagctcgggc cgagcaacgc ggccatgggc tacgcggtgc ccgcggcggt
    19381 cgcggcgaaa ctcgccgaac cacgccggac ggtgatcgcg atggcgggcg acggcggcgc
    19441 gctgatgacc gggcaggaga tcgagaccgc cgtccgctac cgggtgccgg tgaccgtcct
    19501 ggtgttccag aacggagtgc acggcccgct cgccgtgcac caggcgcgca agcacggccg
    19561 gctgtccggg gtcaccgtcc ccatcaccga cttcgcgtcg tgggcgcgcg ggctcggcgc
    19621 cgccgggtac accgtggacg atcgggaaga gctggagccg atcatcgcga gcgcgctggt
    19681 gcggcaacgg ccttgtgtga tcgacatccg cacggatccg gacgtggtga ccccggacat
    19741 ccggctgacg agcctgctgg gcgccgcgag gccgcagcag ggcggccagt aggggccgcc
    19801 acgccgacta ccgggcggta ctttttctca ggggatacac agaaaccctt gtggtgccgc
    19861 cttcacctgc cccaaagggt gggaacgagg tgacgactcg gccgactttc ggtcgcggac
    19921 accggatttt gtcggccggc cgtggcacaa tcgcggcatc accgagagtc cgatatggac
    19981 cggggcaatg gccggtgtgg ttgttggcac gcagtacgta cgtagagcgt tgtgttgaca
    20041 ctgggagaaa acatggctga cgaagcgaag ccacaggaca agtccgtttc cggcgtggtg
    20101 ccggtgcagt tcagcgcgga cgcggagacc cacgacatcg ccgtcgtggc cacgaaccgg
    20161 gaggcgttgc gccgctcgcc gttcggcacc gaggcgccgc tgcgcgccgc cagcggcgaa
    20221 tagcccggcc ggtcgcccct cctgtcggag gggtacagtg cggctgcgca cacccgggtg
    20281 atggcgcttg tcggcctgcg tgaggtgtgc tttactgcac caggtctcga tttttgtgtt
    20341 cgtgttggtt cacgctcgca gaactcagcg ggcgtagtgt ctcctcgtgt ttccggggaa
    20401 gcaaaccgtc tggtcatgac ccgggctgcc gacgtggctt cctgtttgtt tgtgttgcat
    20461 atggagattt tatgactcag ggcactgtga agtggttcaa ctccgagaag gggttcggct
    20521 tcatcactcc cgacaacggc ggcggcgacg tcttcgtgca ctacagcgag atcaagggca
    20581 acggcttccg taccctcgag gagaacgccc gcgtggagtt cgagatcggg cagggcgcga
    20641 agggtccgca ggccacctcg gtcaccgtga tctgatccag gttttccaag cagggccgtc
    20701 atcccctcgg ggaggcggcc ctgctgcttt tccggctcgg tccggttggt cgtgagtggc
    20761 gtttcgggtt ctaacccgaa acgccactca cgaccacctg taccgagcgg ccgcagacac
    20821 gcgggcaccc cgtcttcgtc cgctcaagtt tcggtggctt tgtgatgcaa cctcgtgcaa
    20881 ctctttcttt cgtggcccgg acgtcgtttc cttgtaggga cttggcgcgg cagcggagga
    20941 catgtgggcg aagcggttgc ggggatcgtg gcgaaccccg cttcggagcg tgacatccag
    21001 ggcctgcgtt cggcactgag ggtggccggc gtcggccgcg tgatggtgtg ggccgacgcg
    21061 ggcaagatca tcggcaccgt ccgccggatg gtggacgcgg gtgcgagcgt gctcatctgc
    21121 ctcggtaacg agagcatgat gcgggccgcg gcggccgcct gcggtgacgt cccgctgctg
    21181 atgctgcccg ccggtggcgc cgacgagtcc accgtcgccg ggctcgccgc cgggctggtg
    21241 gccacccatc aggtggacac ggacctggtc acgaaccgcg ccaccgtgct cgaggtcgtc
    21301 acgaaggcac gccgtgagat cgcgctgacc gacgtcagcg tgtgctcgga gagccggtgg
    21361 gatcccgcgt cgctgaccga gctgtactgc acgttcgcgg ttccggacgg ggtcgggctg
    21421 tcgagcatcc ccgggcggct ctgtcccagc ccgaagtcca ctgtggacgg tgtcgcggtc
    21481 tcgctcgggc cggtcgacga gacgccgtac gtggtgcagg cgccgatcgc gcccggcgac
    21541 gtccgggcgg tgggtgtccg cggctggagc gtgctgcacg ccggggtccg cgtcgatctc
    21601 gccgccggcg gcggctccat cgcgctggac ggccagccgc atttcgtgct caagccggga
    21661 gagagcgctt tcgtcgaatt gaagccggac gggccgtggt gcgtcgacgt ccgcgccgtg
    21721 atggccgagg ccaccaggac cggtctgctg ctgggcagga aaccgacggc ggcccttccc
    21781 gcgccccgcc tggcggacgc acccttcccc ggatagcccg cgcccaggtc acagagacct
    21841 tccgctcccc gggccacccg ggcacactgg cctgaacaga gcagaaggag taggccaggt
    21901 gcagctcgag gcggcgctgc cggtcggtgc ggatccgcgg cggcacgcgc gtgccctcgc
    21961 cgaagtgcgc gaggccgcgc tcgccgggac cacgctcccg ggcaggcccc gcgcggtgat
    22021 cggcgcgtcc tggcagcgga tgcggcggct gggcctcgac ccggaccgcg gctcgccgac
    22081 ccctccgctc gccccggaac agctggaagc ccggcgtcgc gacagcggcc tcgcgaccgt
    22141 gctccccgcc cttcgcggcg gcctgatcgg cctcgccgag caggccgcgc acatcatggt
    22201 cgtcgtcgac gccgacggcc gggtgctctg gcgcgacggc agcaccgcgg tccgccgtcg
    22261 cgccgacggg ctcggcttcg tcgaaggggc cgattggcac gagcccgcca cgggcaccaa
    22321 cgccatcggg acggcgctgg tcgccaggca tccggtgcag gtctactcgg ccgagcacta
    22381 cgtcagcaac cagcacgact ggacctgcgc cgccgcgcca ctgcacgatc cgaggaacgg
    22441 caggctgctc ggcgcggtcg acctctcggg accggcttcc accgtgcatc cgtccaccct
    22501 cgccctggtc gacgcggtcg cgaagctcgc cgaagcgcat ctgc
//
