LOCUS       NZ_KB976671            25239 bp    DNA     linear   CON 01-APR-2024
DEFINITION  Bacillus toyonensis strain HuA2-3 acrHg-supercont1.9, whole genome
            shotgun sequence.
ACCESSION   NZ_KB976671
VERSION     NZ_KB976671.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus toyonensis
  ORGANISM  Bacillus toyonensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 4008403)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Bacillus cereus HuA2-3
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4008403)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2012) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Taxonomic-Update-Statistics-START##
            This Genome (query)               :: GCA_000399405.1
            Current Name                      :: Bacillus toyonensis
            Previous Name                     :: Bacillus cereus HuA2-3
            Date Updated                      :: 2022-03-10
            Analysis Type :: Average Nucleotide Identity (ANI)
            Analysis 1 (A1) :: Query vs. TYPE genome for current name
            A1 Genome (subject)               :: GCA_000496285.1
            A1 Name                           :: Bacillus toyonensis
            A1 ANI                            :: 99.4201%
            A1 Query Coverage                 :: 83.75%
            A1 Subject Coverage               :: 94.68%
            Analysis 2 (A2) :: Query vs. TYPE genome for previous name
            A2 Genome (subject)               :: GCA_006094295.1
            A2 Name                           :: Bacillus cereus
            A2 ANI                            :: 91.7421%
            A2 Query Coverage                 :: 77.41%
            A2 Subject Coverage               :: 80.96%
            ##Taxonomic-Update-Statistics-END##
            ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R41865
            Assembly Name                     :: Baci_cere_HuA2-3_V1
            Genome Coverage                   :: 108.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_000399405.1-RS_2024_04_01
            Annotation Date                   :: 04/01/2024 01:17:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,841
            CDSs (total)                      :: 5,738
            Genes (coding)                    :: 5,542
            CDSs (with protein)               :: 5,542
            Genes (RNA)                       :: 103
            rRNAs                             :: 6, 4, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 3, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 81 of 196
            Pseudo Genes (incomplete)         :: 115 of 196
            Pseudo Genes (internal stop)      :: 62 of 196
            Pseudo Genes (multiple problems)  :: 52 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:43:02
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1666952
            Orig. end                         :: 1692191
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB976671.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            The organism was changed from 'Bacillus cereus HuA2-3' to 'Bacillus
            toyonensis' in March 2022.
            Please be aware that the annotation is done automatically with
            little or no manual curation.
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="4"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(907..1476)
                     /locus_tag="IG5_RS16525"
                     /old_locus_tag="IG5_01686"
     CDS             complement(907..1476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="IG5_RS16525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01686"
                     /product="hypothetical protein"
                     /protein_id="WP_000782800.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPTTSVFAAEKEAPIQQKEAQVSI
                     QPFAQNNLETAVNAALNGPEVKKIKVFEHEFNVKEIEVVNLGAGKKYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFAAPLLSILAAYNGIPVNPNDLNALGQQ
                     LGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    complement(1802..1815)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.21"
                     /tool="antismash"
     gene            2135..2976
                     /locus_tag="IG5_RS16530"
                     /old_locus_tag="IG5_01687"
                     /pseudo=""
     CDS             2135..2976
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="IG5_RS16530"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01687"
                     /product="metallophosphoesterase"
                     /pseudo=""
                     /sec_met_domain="Metallophos_2 (E-value: 6.5e-09, bitscore:
                     34.0, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKTKRIILLIGTIVGICIFLYLQNNLISITEVKITSSKIPSAF
                     KGYKILQISDLHNKKFGDNQDILIQKVKSINPDIIAITGDLIDSKSYDEEISMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKELKKNHVTVLRNEHVIIQKGGQEINLLGIDDPEF
                     NNRDINEGSIVKDAIVKAKIETQPNRYNVLLSHRPEFIEEYAEERIDLVFSGHAHGGQV
                     RLPFISGLVAQNKVFYLNIQQVYMKNKIHQWWLVED"
     gene            3192..3443
                     /locus_tag="IG5_RS16535"
                     /old_locus_tag="IG5_01688"
     CDS             3192..3443
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="IG5_RS16535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01688"
                     /product="hypothetical protein"
                     /protein_id="WP_000548627.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCQCLLVSHPEQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDLARIRKYMNLET"
     gene            3630..4355
                     /locus_tag="IG5_RS16540"
                     /old_locus_tag="IG5_01689"
     CDS             3630..4355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108448.1"
                     /locus_tag="IG5_RS16540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01689"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_001171599.1"
                     /transl_table=11
                     /translation="MQKPSIVLQNVSKSFGKKEVLHDLSLQIEKAEIFGLVGPSGSGKT
                     TLIKLIAGINQASKGDVFVYNINMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKHKKERIKEVFDLVQLSQHMKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWGKFYELKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAVGTPEELKK
                     RVSSGRIEDVFLLEEGVES"
     gene            4352..5371
                     /locus_tag="IG5_RS16545"
                     /old_locus_tag="IG5_01690"
     CDS             4352..5371
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="IG5_RS16545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01690"
                     /product="ABC transporter permease"
                     /protein_id="WP_001265602.1"
                     /transl_table=11
                     /translation="MRVNGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYK
                     PHIAVVDVPASIVKVMKNQEASIYEYSKKKAISELEKQKIDAVIHLENGKINLLLEGSD
                     SSKNRAVLQVLQKSTEKNDVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVVGYIIGFGIFAFIQSVIIVSFSVYVLDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPIESMNKW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            5396..6049
                     /locus_tag="IG5_RS16550"
                     /old_locus_tag="IG5_01691"
     CDS             5396..6049
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="IG5_RS16550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01691"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_000711180.1"
                     /transl_table=11
                     /translation="MKKDWLEELIAATNTDNRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQAFAKEIFKTDYESYEGLL
                     RVVIHNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLVETELLSHFKKLIVKFQEEGG
                     IIEMPPPSVLRLTLSAVLGFLLTRFLLLPEENWDDELEIENTIQFILYGLTPRR"
     gene            6054..7022
                     /locus_tag="IG5_RS16555"
                     /old_locus_tag="IG5_01692"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="IG5_RS16555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01692"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_001248628.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGIPRETIRIVEENGVNTLVQPSTREDVTEKMEQFSNGFLQTISDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGPGLFGGAVLKNFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKDLVSFQSDNKYLFMAYNQVKQKELGRIIANQKNETIEIVFD
                     NYEKTLYELFLRAPRYTSNVNVCEHIFGYFKTKLKKQEKDYFLELIQKYAEKKIPLSSL
                     LAILKSWAIRFDEKYLLGQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="IG5_RS16560"
                     /old_locus_tag="IG5_01693"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="IG5_RS16560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01693"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397277.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.4e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.7e-26, bitscore:
                     88.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.1e-56, bitscore:
                     189.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGVEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKTISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="IG5_RS16565"
                     /old_locus_tag="IG5_01694"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="IG5_RS16565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01694"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486760.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2e-10, bitscore:
                     38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.7e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.2e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 3.6e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNVEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNIRMDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LENALEELKIEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     misc_feature    8443..8457
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     gene            9764..9979
                     /locus_tag="IG5_RS16570"
                     /old_locus_tag="IG5_01695"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="IG5_RS16570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01695"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="IG5_RS16575"
                     /old_locus_tag="IG5_01696"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="IG5_RS16575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01696"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775419.1"
                     /sec_met_domain="HMGL-like (E-value: 7.1e-49, bitscore:
                     164.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALTVIEDITKQAIFEGKKVRGYVSTVFGCPYEGDISAAAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEHGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLWRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="IG5_RS16580"
                     /old_locus_tag="IG5_01697"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 2.3e-74. Score:
                     241.7. Matches aSDomain: nrpspksdomains_IG5_RS16580_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="IG5_RS16580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01697"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_000939822.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLEELQTILTEI
                     SEESNTRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVGMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASENASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIANQIASNGPIAVRLAKEAISNGVQV
                     DLHTGLQMEKQAYEGVIHTEDRLEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IG5_RS16580_ECH.1"
                     /evalue="2.30E-74"
                     /label="IG5_RS16580_ECH.1"
                     /locus_tag="IG5_RS16580"
                     /protein_end="254"
                     /protein_start="14"
                     /score="241.7"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLEELQTILTEISEESNTRVVILTGA
                     GEKAFCAGADLKERAGMNEEQVRHAVGMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASENASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIANQIASNGPIAVRLAKEAISNGVQVDLHTGLQMEKQAYE
                     GVIHTEDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="IG5_RS16585"
                     /old_locus_tag="IG5_01698"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="IG5_RS16585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01698"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000893092.1"
                     /transl_table=11
                     /translation="MLEQKQQSNNFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLMTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRIIDDGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIIVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13299..15239
                     /locus_tag="IG5_RS16590"
                     /old_locus_tag="IG5_01699"
     CDS             13299..15239
                     /NRPS_PKS="Domain: AMP-binding (97-521). E-value: 3.8e-82.
                     Score: 268.0. Matches aSDomain:
                     nrpspksdomains_IG5_RS16590_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="IG5_RS16590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01699"
                     /product="AMP-binding protein"
                     /protein_id="WP_000806475.1"
                     /sec_met_domain="AMP-binding (E-value: 4.7e-87, bitscore:
                     290.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNDGTCNVVESALSRWIADEVTRKQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKQAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNNFTPHHYDFSWSTLEKEKPFIHAEEMHSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHINVIEAASIGVPDDVKGEVCHCFVVLRDGVIFTAELKK
                     ELMSLVNSHIGKALCPKDIHVVADLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PHIQGLQSSKL"
     aSDomain        13590..14861
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IG5_RS16590_AMP-binding.1"
                     /evalue="3.80E-82"
                     /label="IG5_RS16590_AMP-binding.1"
                     /locus_tag="IG5_RS16590"
                     /protein_end="521"
                     /protein_start="97"
                     /score="268.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="RKQPALQYEGENGTSKSFTYEELDNWVSRVANGLKQAGIEKGDRV
                     TIYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGK
                     IVSLKDEVDKACEHCPTVEKVVIVRHAGNNFTPHHYDFSWSTLEKEKPFIHAEEMHSDD
                     PLMLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLL
                     FGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHS
                     LKSLEVFASTGEPWNPDPWMWLFETVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPIS
                     FNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKW
                     VHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14085..14141
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IG5_RS16590_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="IG5_RS16590"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14832..14894
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IG5_RS16590_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="IG5_RS16590"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15705..15872)
                     /locus_tag="IG5_RS31180"
                     /old_locus_tag="IG5_01700"
     CDS             complement(15705..15872)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000358201.1"
                     /locus_tag="IG5_RS31180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01700"
                     /product="hypothetical protein"
                     /protein_id="WP_000358199.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDHVSSDALNTPSKAQEQMQETSQKAHNSNKKGNT
                     QSLHVEDLPN"
     gene            complement(16174..16674)
                     /locus_tag="IG5_RS31915"
                     /old_locus_tag="IG5_01701"
     CDS             complement(16174..16674)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108454.1"
                     /locus_tag="IG5_RS31915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01701"
                     /product="exosporium leader peptide-containing protein"
                     /protein_id="WP_016091106.1"
                     /transl_table=11
                     /translation="MDEFLSFVAHNPGSIGPTLPPVQPFQFPTGPTGSTGATGSTGPTG
                     STGPTGPTGPTGFNLPAGPASITLTSNETTACVSTQGNNTLFFSGQVLVNGSPTPGVVV
                     SFSFSNPSLAFMVPLAVITNASGNFTAVFLAANGPGTVTVTASLLDSPGTMASITITIV
                     NCP"
     gene            complement(16872..17240)
                     /locus_tag="IG5_RS16600"
                     /old_locus_tag="IG5_01702"
     CDS             complement(16872..17240)
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="IG5_RS16600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01702"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_000526889.1"
                     /transl_table=11
                     /translation="MGNIPKVSSHQSSPNIPSQQVNPNTQQGNRKKTRRRIITTLAIMV
                     PIIFVLQYSLNNQQEMIKEKQITLNTEQQKLSSVKKDGHSLKNDVKALTSSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            17876..18256
                     /locus_tag="IG5_RS16605"
                     /old_locus_tag="IG5_01703"
     CDS             17876..18256
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="IG5_RS16605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01703"
                     /product="hypothetical protein"
                     /protein_id="WP_000450239.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGTVILHNVWAFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRILS
                     TRIALAIIGALALWMLIVIYIK"
     misc_feature    complement(18300..18313)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     strong, score: 26.74"
                     /tool="antismash"
     misc_feature    18476..18489
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.37"
                     /tool="antismash"
     gene            18648..19109
                     /locus_tag="IG5_RS16610"
                     /old_locus_tag="IG5_01704"
     CDS             18648..19109
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000569864.1"
                     /locus_tag="IG5_RS16610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01704"
                     /product="hypothetical protein"
                     /protein_id="WP_000569863.1"
                     /transl_table=11
                     /translation="MIEIKSMIYSYKLKRRIAKDLYGSRDELTMLLNEFNNMKSKLKSD
                     KKKNNMLSRLQLMYQNMKLDKQYSLPFALNSRLLERLEDESIQTTEECVSCLHVMLEIN
                     YEKIQHYGSNTSRSFVPLSQSSICLADFVCLTGFVLLGLLGTITFGGIM"
     gene            complement(19663..19875)
                     /locus_tag="IG5_RS16615"
                     /old_locus_tag="IG5_01705"
     CDS             complement(19663..19875)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IG5_RS16615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IG5_01705"
                     /product="hypothetical protein"
                     /protein_id="WP_176519091.1"
                     /transl_table=11
                     /translation="MMTGGSLKKSIIVMMIGVLRKSIVMMIGGNLKKSIIVMMIGVLNE
                     ISVVVNVSLFVVIVKENIGKILMST"
     gene            20517..20873
                     /locus_tag="IG5_RS16620"
                     /old_locus_tag="IG5_01706"
     CDS             20517..20873
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="IG5_RS16620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01706"
                     /product="hypothetical protein"
                     /protein_id="WP_000535569.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEIFEECKKEKHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVASVSCDVVKLAAIPGSVAVIISICKIEAIFPPVTTIT
                     AEFDFNGVDVANKA"
     gene            20977..21516
                     /locus_tag="IG5_RS16625"
                     /old_locus_tag="IG5_01707"
     CDS             20977..21516
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002065535.1"
                     /locus_tag="IG5_RS16625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01707"
                     /product="GNAT family protein"
                     /protein_id="WP_073990635.1"
                     /transl_table=11
                     /translation="MMYERRMRVIKLVPFKRSDFKQLINWIHSEQFLIQWSGNAFTYPL
                     NEQQLEKYIESANTLAFKVIDEKTEEVLGHISLGQIDDINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFEELKLHRVTLGVYDFNTSAISCYEKIGFVKEGLLRDSKKVGETYW
                     NLWEMSMLEYEWNNKK"
     gene            21567..22127
                     /locus_tag="IG5_RS16630"
                     /old_locus_tag="IG5_01708"
     CDS             21567..22127
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127500.1"
                     /locus_tag="IG5_RS16630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01708"
                     /product="hypothetical protein"
                     /protein_id="WP_001080627.1"
                     /transl_table=11
                     /translation="MNRKTIVITIAAVSGGGKTTITESLTHELTNSKALFFDSYNFDNC
                     PADICKWIDDGANYDEWVLTPLIHDIQHLIRDSKLDYIIVDYPFAYLNREMGQFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNDLKHYMAHARKAYLEAIHTVKPNSDIVLDGS
                     FSVSEIIDHVVEELDRREVIVNG"
     gene            22120..22860
                     /locus_tag="IG5_RS16635"
                     /old_locus_tag="IG5_01709"
     CDS             22120..22860
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-131). E-value:
                     1.1e-12. Score: 40.1. Matches aSDomain:
                     nrpspksdomains_IG5_RS16635_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237666.1"
                     /locus_tag="IG5_RS16635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01709"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_000237661.1"
                     /sec_met_domain="PF00561 (E-value: 8.9e-08, bitscore: 30.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.4e-06, bitscore:
                     27.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKCIEEYVQVDDFKMYTKVFQGKKRQPVIIMESGYGDYSKAWDY
                     IAERLTEFGTILTYDRAGLGKSGKSFKQRISSEMVKDLRTCLNLLQLKPPYIFVGHSFG
                     GINARLFTVFYPEDMLGTVLVDSTPENYKEVFLPIMSPEFQEAYYKQFAYESSYEEFMF
                     SLGEADRHCKSMNDIPLVVLAAGKKAFYSQAAQLKWLQLQRELLQLSSKSKFIIAEHSG
                     HYIQKDEPHYIIGAVKWILGVGER"
     aSDomain        22201..22512
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IG5_RS16635_Abhydrolase_1.1"
                     /evalue="1.10E-12"
                     /label="IG5_RS16635_Abhydrolase_1.1"
                     /locus_tag="IG5_RS16635"
                     /protein_end="131"
                     /protein_start="27"
                     /score="40.1"
                     /tool="antismash"
                     /translation="PVIIMESGYGDYSKAWDYIAERLTEFGTILTYDRAGLGKSGKSFK
                     QRISSEMVKDLRTCLNLLQLKPPYIFVGHSFGGINARLFTVFYPEDMLGTVLVDSTPEN
                     "
     CDS_motif       22402..22437
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IG5_RS16635_0001"
                     /evalue="6.50E-05"
                     /label="NRPS-te1"
                     /locus_tag="IG5_RS16635"
                     /protein_end="106"
                     /protein_start="94"
                     /score="15.5"
                     /tool="antismash"
                     /translation="PYIFVGHSFGGI"
     gene            22863..23321
                     /locus_tag="IG5_RS16640"
                     /old_locus_tag="IG5_01710"
     CDS             22863..23321
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="IG5_RS16640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01710"
                     /product="DinB family protein"
                     /protein_id="WP_016091107.1"
                     /transl_table=11
                     /translation="MYTVFQYNWQVREDWFKWCEQLTVEELLRKCVGGVGSILETLFHI
                     VDVEYSWICDLKGKEVDEPQFKDYQSIQKVKALSHLYNKDLEGFLQSWTEDLENKILKV
                     SWTDKEYKYGEVLRHVVVHEIHHIGQLSIWARELNLQPVSANLIGRGL"
     gene            complement(23380..24396)
                     /locus_tag="IG5_RS16645"
                     /old_locus_tag="IG5_01711"
     CDS             complement(23380..24396)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="IG5_RS16645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IG5_01711"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_001160069.1"
                     /transl_table=11
                     /translation="MQFLKKFTILLLSFIITALIVLYFYLYVNGPIIQAKSAILIDANS
                     GEVIYKKNEETPIQSATLSKLMTEYIVLEQLNDGKIQLDESVKISNELFQAETTPMQVT
                     AKDKTTVRDLLHALLLTGNNRSALALAEHIGGNEDNFTTLMNEKAKQLQLSQPSPFLNS
                     TGANQDTNKQSNTTAKDAAKLATHLVKDFPNVLNMTKLTSYQFTFKNFQVFNTNKMIYS
                     LNENIKFQGVDGLQTSFSTNGNNSFVGTAKLGDTRLISVILESDEENTTFIETKKLLQY
                     GFEPSSYSALQAFKDTLTSWAILLQFKNLIIQTMMIFFIITILMFLHLRQRKSEDFN"
ORIGIN
        1 tcctcaaatg atagtgatcc actttcagga gtagtttctt cttttaagcg cattaaaatt
       61 gtttctgtcg gataatcttt taaaaattga attgcctctt ttaatacatc ttcaaacatt
      121 gctttttgat ttacaatccc atggtacatt gcaaaagaat cttttacacg tttaacacgc
      181 atatctacat atcgaattcc agaatttaat tgttgaggta gactcatagt ttgatttctt
      241 gtcaaatttt catcaagaaa acttgctcca tgtaaagcca ttgtaccgtg agtccctgga
      301 atagatattt tacttagttt tgttgaatct tctactttcg acatccacga tggattttga
      361 tatcctatat tggattcata ggaataacct ggatgactat cagctaaaat aggagatggt
      421 gtacttaaac ttgctagtgt aaaacatgtg aggatgctaa ttttaaagaa atttattatt
      481 tttattttgt tcattttatc tctcctgacc tttaaacaat agattaagat gattttgtac
      541 tatatttatt gttttcattt taaagtaatg aaattttgtg tttgaaaata attaaaaata
      601 gggggagtaa cttatttgag actttaataa tttgttgtta tgaattgtac ttaataacca
      661 aacggattct taaagaatcg aagtatagac tcgaaaaaac aaccttttat cgtattgtat
      721 acaaacaaaa cagaagcctt aaaaaagact tctattctgt gacatataat gaatgataag
      781 gtggttaaca aatcaagata atgtgactga gtggtaaaaa tctatttata gctgtttcag
      841 aatctcttat aacaaggtta cctacgaaaa atgggcctct gcaaggctaa taaaaattaa
      901 aaagttctac tcattaaaac ttaaactaac tacagttgcg atagattggg ctgcatgttc
      961 ccagcttcca tctataactt ttccaagctg ctgaccaagt gcatttaaat catttgggtt
     1021 aactggaatc ccattatagg cagcaagaat tgataaaagt ggagcagcaa atggtgtcca
     1081 accacctcta tcaatattaa atacaggctt atctattacc tttccatctt gcactgtaaa
     1141 ctcataataa aattgatcat ctggacgaaa acttaaatga tgagaaattt gccccttaac
     1201 atattttttt ccagcaccta gatttactac ttctatttct tttacattaa attcatgctc
     1261 aaatactttt atttttttga cttctgggcc atttaaggca gcattaacgg ctgtttccaa
     1321 attattttgt gcaaatggtt gaatactcac ttgtgcctct ttttgttgga taggagcctc
     1381 tttttcagca gcaaacaccg atgtagttgg tagtgcacct gtagctaatg tagccgcaag
     1441 tgctgttgtc atcatgattt ttcttttcat cttcatagtt ttccttcctc tcttaaagtt
     1501 atgatatata atcttttaaa gactgacacg gtgcaatata ttatttcata atgcacgcaa
     1561 aaaatagttt aagaattatg tgaaactatg tcagaaaatt aaagttaatt atatattcat
     1621 ttacaatgat atctatctac acacattttt tcaattttct aataaataat ataataataa
     1681 cttttcataa gggaatttaa tgttttaatt ctctctatat acgctttaaa caaattaaaa
     1741 tcgtagtggt aataatatat ttgcaagcaa atgtcatata tacttcgaga aaaatacaca
     1801 atttttttat aaaaaacttt aggaattatc attatatcgt tattaactaa ataagataaa
     1861 tgataatatg atgaagagct tccagggatt cgctataaat tcactagaga atgagcatga
     1921 tatcatacac tcatgcagga cgcctaggat attaaagctc cactttatag taagttaata
     1981 cgaaggagat tggaaacagc agtaagtgtt tattagagac gtataacact atgaaaaata
     2041 cttcaaatta attggaaagt ttcagttttt tgaattcaaa gggcacggaa tgtttattag
     2101 aattgtagtt ctgattaaga ttttaggagg aaaaatgaac aagaagacta aaagaatcat
     2161 attacttatc ggtacaatag taggtatttg catcttttta tatttacaga acaatttaat
     2221 aagtataact gaggttaaaa taacctctag taaaattccc tccgctttta aagggtataa
     2281 aattctacaa atttcagatt tacataataa aaaatttggt gataatcaag acattttaat
     2341 tcaaaaagta aaaagcataa atccagatat tattgctatt actggtgatt taatagacag
     2401 taaatcgtac gatgaagaaa ttagtatgca agtaatacga gaacttgtaa aggagtatcc
     2461 ggtatatttt gtaacaggaa accatgaaaa atggtcagga aaatataaca gtttagaaaa
     2521 agaattaaag aaaaaccatg ttactgtttt gagaaatgaa catgtaataa tacaaaaagg
     2581 cggacaagaa ataaacttgt taggtattga tgatccggaa tttaataaca gagatattaa
     2641 tgaaggaagt attgtaaaag atgcaattgt aaaagcgaaa attgaaacgc aaccaaatag
     2701 atataatgta ttattatccc ataggccaga atttattgag gagtatgcag aggagcgaat
     2761 agatttagtt ttctcagggc atgctcatgg tgggcaagtt aggttaccat ttatcagcgg
     2821 attagttgct caaaacaagg tgttttacct aaatatacag caggtttata tgaagaacaa
     2881 aatacatcaa tggtggttag tagaggatta ggcaatagta tcattccgca aagaattttg
     2941 aataggccag aaattgtagt cgcccagtta aattaaattg ggcgactttt tatgtacaga
     3001 atgagtaaag gggctttatg tattttgcag gagttaacat tacaattttg ttaaaaattt
     3061 tctacgttac ataaagtaac aaaatttgac ctgaagagtt tgttatagtg taaataatca
     3121 aaaaacttaa aaattagtcg agtgaaaagt gtgataagga atttatgtaa aaaacttaaa
     3181 ggggtgtaca catgcataaa gaatatgaaa ttgaagagta tacggcgatt gaggaacaaa
     3241 tacattatta ttgtcaatgt ttattagtga gccatcctga gcaaattata aaatatttag
     3301 aaaaaagatt agaaaaatat gcagaaacat tacaatatgc acatttatat cccgatacag
     3361 ttattttacc gttacagcaa ttagttatcg aatattcttt agaccttgct agaattagga
     3421 agtatatgaa tttagaaaca taaagtaaaa tgcatagttt aaatgaaaca gagtcgactt
     3481 taagaaatta tattctaatg tcgattctgt ttcattgttt aatattgttg attgaaaata
     3541 aatactaatc aatgaagttt gacatataat tacgcaagag taaaataaaa gtgagtactc
     3601 actcatttta tagaaaagag ggataataca tgcaaaaacc ttcaattgtt ttacagaatg
     3661 tatcgaaaag ttttgggaaa aaagaagttt tacacgatct ttcattacaa attgaaaaag
     3721 cagagatatt tggtttagtt gggccttcag gatcagggaa aacgacgctt attaaattga
     3781 ttgcaggtat taatcaggca tctaaaggtg atgtatttgt atacaacatt aacatgccaa
     3841 atttaaatga gatgaaaaga attggctata tggctcaagc tgatgcatta tacgaagaac
     3901 tatcagcata tgaaaatgca gattttattg caacgatgta tggattaaag ggaaagcata
     3961 aaaaggaaag aatcaaagag gtttttgacc tggtacaatt atcacaacat atgaaaaagc
     4021 aagtacagca tttttcaggt gggatgaaaa agcgtctatc attagcaata gcacttcttc
     4081 atgaacctga aatattaatt ttagatgagc caacagtggg gatagatccg cttcttagaa
     4141 aaacaatctg gggaaaattt tatgaactta aaaagaaagg cacaactatt attgtaacga
     4201 cgcacattat ggatgaagca gagttttgtg agcgtctagg gttgattaga gaagggaact
     4261 tagttgcggt tggaacgcca gaggaattga aaaaacgtgt atcatctgga cgaattgaag
     4321 atgtcttttt gttagaagag ggggttgaat cgtgagagtt aatggtgtaa tcattcgtat
     4381 tattcgtcaa ttttttcgag ataaacgttc gttagccatg atgtttgggg caccaatgtt
     4441 attactttgg ctattgtctt tagtatttac acaaaaagat tataaaccac atattgctgt
     4501 agttgatgtg cccgcttcta tagtaaaagt gatgaaaaat caagaagcct caatttatga
     4561 atatagcaaa aagaaagcga tttctgagtt ggaaaaacaa aagatcgatg cagtaattca
     4621 tttagagaat ggaaaaataa atcttttgtt agaaggcagt gattcgtcga aaaaccgtgc
     4681 tgtactccaa gtattgcaaa agagcacaga gaagaatgat gtatcgatta tgaaacctga
     4741 agtgaattat ttacatggct ctaaagactt tacgatgttt gatgggctcg gtcccgtgtt
     4801 aattggattc tttacatttt tctttgtatt cattttgtca ggagtttctt tcgtaagaga
     4861 acgtttaagt ggtacattag agcgattatt gtccacacca gttagacgat gggaaatagt
     4921 tgttggatat ataattggtt ttggaatttt tgcattcata caatctgtta taattgtaag
     4981 tttttcagtc tatgttttag atttatatgt agcaggttct atatggctaa cgctacttat
     5041 tacatgtatg ctctctttaa cggcactaac attagggacg tttttatcag catacgcaaa
     5101 taatgaattt caaatgatcc agtttatacc gctagttatt gtgccacaaa tcttcttttc
     5161 tggcttgttt ccaattgaat ctatgaataa gtggctacaa atgttaggga aattatttcc
     5221 actcacatac ggcgctgatg caatgaggca agtgatgatt cgaaatcaag gatttacaga
     5281 aattgcattg gatcttactg tattactact tttttcacta ttatttgcag tagggaatgt
     5341 atttgcttta aagaaacatc gcaaaatata ataatgacaa aaaggagctt tgtacatgaa
     5401 gaaggattgg cttgaggaat tgattgctgc aactaatact gataatcgaa atgaacgtca
     5461 aatgcgtatt ttagaagcag ctgttgatat gtttggagaa aaaggatatg cttcaacttc
     5521 aacaagtgaa attgcaaagc gtgctggtgt agcggaagga acgattttcc gctactataa
     5581 gacgaaaaaa gatttattgt tagcggtcgt aatgccaact ttaacaaagt ttgctgcacc
     5641 atttttcgta caagcttttg cgaaagagat atttaaaact gattatgaat cgtatgaagg
     5701 gcttttaagg gtagtcattc ataatcgatt tgaatttgcc aaaaagcact ttccaatgat
     5761 taaaatatta attcaagaag tgccgtttca gccagagcta aaaagtgaaa tacaacaatt
     5821 agtagaaaca gaactgcttt cacattttaa aaagttaatt gtaaagtttc aagaagaagg
     5881 gggaattatt gagatgccac caccttccgt gttacggctt acattatcag ctgttttagg
     5941 atttctatta actcggtttt tattattacc tgaagagaat tgggatgatg aattggaaat
     6001 tgaaaatacg attcaattta ttttgtacgg actaacgcca cggaggtaat gaaatgcgac
     6061 aatttgcaaa acctacaatc gtcgtaagta aatgtttaga atttgatgct tgtcgttata
     6121 atggagaaat gattccggat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag attggattgg gaattcctcg tgaaacgata cgaatcgtag
     6241 aagaaaatgg tgtgaataca cttgtgcaac cgtcgacaag agaagacgtt actgaaaaaa
     6301 tggagcaatt ttcaaatgga tttttacaaa cgatatccga tgtggatgga tttattttaa
     6361 agaatcgctc gccaagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 cgccagcaaa aggaaaggga ccaggcttat ttggcggagc agtattaaaa aatttttcgc
     6481 accttccaat tgaagaagaa ggtagattgt cgaattttat tattagagaa catttcttta
     6541 caaggttatt tacaatcgca tattacaaaa tgattaaaca taataaaaat atgaaagacc
     6601 ttgtatcgtt tcagtcggac aataaatatt tatttatggc atataatcag gtaaaacaaa
     6661 aagaattagg gcgtattatt gcaaatcaaa aaaatgaaac gattgaaatt gtatttgata
     6721 attatgagaa gactttatat gaattatttt tgcgcgcgcc ccgctataca tcgaatgtaa
     6781 atgtatgtga acatattttc ggatatttta aaacgaaatt aaaaaaacaa gaaaaagatt
     6841 attttttaga actgatacaa aagtatgcag aaaagaaaat accacttagt agtttgcttg
     6901 caattttaaa atcatgggcc attcggtttg atgaaaagta tttattagga caaacatatt
     6961 ttgagccata tcctgaagcg ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacataaaa cttcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagcac agaatctgtt ttaaaattaa gttatgacag aattgtagca
     7141 attgtctaac taatattctt gtcttttaag aagtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtgtatta tgacaaaact gcagagtttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggcatccca ttcccagaag agtatggagg ttcaggtggc gatacagtat
     7441 cgtacgcgct agcagttgaa gaaattggtc gtgcttgtgg tggtacagga ttaagctacg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 aaaaatattt agttccaatg gcatcaggta aaacgttagg cgctttcgga ttaacggagc
     7621 caaacgctgg atcagatgca ggaggcacac aaacgaaagc ggtattagat ggtgatgagt
     7681 atgtaatcag tggtgaaaag tgctggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctat caacggtgtt gaagagaatg gtagaaaacg tatttctgca tttatcgtac
     7801 cgactacaag tgaaggatta acgatctcaa gtccttacga taagatgggt gttcgcgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tgcgtgtacc gaaagaaaat attcttggtg
     7921 atgttaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaattg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaaa acaatttcta atttccaagc gattcaattt aaattagcgg
     8101 atatggcgac tgaagtagag ttagcacgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa actatttgca tctgaagcag
     8221 ctagtcgtat tgcgaatcat gcagtacaaa ttcatggcgg ttatggctat atgcgtgaat
     8281 atgaagttga aagacatatt cgtgatgcaa aactgttaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gctagacatt taggatgtag ataaaaagga ggaatcacta
     8401 tgtttcaaaa aatattaatt gccaatcgcg gggaaatcgc agttcgcatt atgaaaactt
     8461 gtcaaaaact tggaattcgt accgtcgcta tttattctga ggctgatgaa aatgcccttc
     8521 atgtaaaaat ggcaaatgaa gcttatctag taggtggtcc acgagttcaa gaaagctatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgttgaagca atccatccgg
     8641 ggtacggatt attatcagag aatccatctt ttccgattcg ctgtaaagaa gaaggaatcg
     8701 tatttattgg tccttcagaa gaaatcatta cgaagatggg aagtaaaatt gagtcacgta
     8761 tagcaatgca agcagcagat gtaccagtag ttccaggtat tactacaaat attgaaactg
     8821 ctgaagaggc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 cgggcggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa caaaacaagg gcacaaaatt tcttcggtaa tggagaaatg tatttagagc
     9001 gttatattgc agacgcgcat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtactt atgggaacgt gaatgttccg tacagcgccg aaatcaaaaa gtaatcgaag
     9121 aagcaccttc acctttttta gatgaaggta cacgaaaagc aatgggagaa gtggctgtac
     9181 aagctgctaa agctcttggg tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaaaaattt ctatttctta gaaatgaata cgagattaca agtagagcat cccgttacag
     9301 aagaaattac ggggttagat cttgtagaac aacaacttct tatcgcaagt ggagagaaac
     9361 tatcatttac tcaggatgat gtaaaacgta gtggtcatgc cattgaagca cgtatttatg
     9421 cagaagaccc gaaaacattc ttcccgtcac ctgggaaaat tacagattta acattaccat
     9481 caaatatacg tatggatcac tttttagaga atcatgtaac aattacaccg ttttatgatc
     9541 caatgattgc aaaagtcatt gctcatggtg aaactcgtga agaggcaatt tcaaaattag
     9601 aaaatgctct agaggagttg aaaattgaag gtattaaaac aaatacaccg atgctactgc
     9661 aagtgctcgg agacgatgtg ttcaaaagtg gtatttatac aacgggtttc gtaacgaaac
     9721 agcttgttaa aaaataagat ttatgaatat taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tttggaagat agttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtagggc cacgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagcc ggattgtcgt acgttgaagt
    10141 ttcctcattc gttcacccaa aatgggttcc tgccttagcg gatgcaaatg atgtcttttc
    10201 tgagctaaaa agggatccca atgttacata tgctgcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag cgagtgaatc
    10321 tcataataaa agtaatatta ataaatcaat taaagaagca ttaactgtta ttgaagatat
    10381 aacaaaacag gcaatattcg aagggaaaaa ggttagaggt tatgtttcta ctgtatttgg
    10441 atgtccgtat gagggagata taagtgccgc agcagttgat gaaatatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctctcgg tgacacgatt ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaaatatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggga tggcacttgc aaatgtagtg aagtctttag aacacggtat
    10681 tacaacgttt gatagttctt gtggtggact cgggggatgt ccatatgcac cgggagcatc
    10741 aggaaatgtt gcaactgatg atttagtgca tatgctccat aagttaggtg tccaaacaaa
    10801 tatagacgaa gaaaagttat ggagagctag tcaatttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaatatttca gttgactatg taacaccgca tgttgtaaag atttcgttat
    10981 atcgtgaaag acaagcaaat tctttatctt tagcgttatt agaagaattg caaacaatat
    11041 taacggaaat aagtgaagag tcaaatacac gtgtagttat tttaacaggg gctggtgaaa
    11101 aagcgttttg tgctggcgca gatttaaaag aacgagctgg tatgaatgaa gagcaagttc
    11161 gccatgcggt tggtatgatt cgtactacta tggaaatggt ggaacaatta ccacaaccag
    11221 ttattgcagc tattaatgga attgctcttg gtggtggtac ggaattgagt ttagcctgtg
    11281 actttagaat cgcttctgaa aatgcaagcc ttggtctgac tgaaactacc cttgcaatta
    11341 tacctggagc aggtggtacg cagcgtttac cgagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cgcaagaagc gaaagaatat ggtttagtag
    11461 aattcgtcgt accagctgat ttactagaag agaaagcgat tgaaattgca aatcaaattg
    11521 ctagtaatgg tcctattgca gttcgattag caaaagaagc aatttctaat ggtgttcaag
    11581 tagatttaca taccggatta caaatggaaa aacaggcgta cgagggtgta atccatacgg
    11641 aagatagatt agaaggatta caggcattta aggaaaaacg caaaccgatg tataaggggg
    11701 agtaaatgtg ttagaacaaa aacaacaatc aaataatttt gaagaacgag ttgaaacgat
    11761 taaacaaggt ggagcaccga aatatcatga acaaaacaaa gcaaaaggaa aactctttgt
    11821 tcgagatcgt ttagctcttc tatttgataa tggcgaatat gtagaagatg cattatttgc
    11881 aaattgtgag caaacagggt taccggctga tggtgttgta actgcaactg gtaaaataca
    11941 tgggcgtact gcgtgcgtaa tggcaaatga ttcaactgtg aaagccggat catggggagc
    12001 tcgtacagtt gaaaagattt tacgtattca agaaacggct gaaaagttac gtgttccatt
    12061 attttattta gttgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcgggaagaa tcttttataa ccaagtgaaa ttatcaggta aagttccaca
    12181 aatttgttta ttatttggtc cttctgctgc tggtggtgca tatattccag ctttttgtga
    12241 cgttgttatg atggtggaag gtaatgcatc tatgtattta ggatctccac gtatggctga
    12301 aatggttatc ggtgagaagg taactttaga agaaatgggc ggggctcgta tgcattgctc
    12361 agtatcagga tgcggagacg ttttatgtaa gacagaagaa gatgcaatta cacaggctag
    12421 acaatacatt tcatattttc caagcaacta cttagaaaag actccattga tgacacctca
    12481 agaaccgaaa cagttcgata aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctga ttaacagaat tatagatgac ggctcattct ttgaagtgaa
    12601 aaaattattt gctcaagaac tcattacagg tttagcacgc attgatggta agccaatagg
    12661 tattattgca aatcagccgc gtatgaaagg tggcgtttta ttccacgatt cagctgataa
    12721 agcagcgaag tttattaatt tatgcgatgc ataccatatt ccattattat tccttgcaga
    12781 tgtaccagga tttatgattg gtacaaaagt agagcgcgct ggtattattc gtcacggtgc
    12841 aaaaatgatt tctgcaatga gtgaagcaac tgtaccgaaa atttctatca ttgttcgaaa
    12901 agcatatgga gctggtttat atgcaatggc aggtccggca tttgaaccag attgctgctt
    12961 agcattaccg acagcttcta ttgctgtaat gggtccagaa gcagcggtca atgctgtata
    13021 tgcaaataaa attgcggctt taccagaaga agagcgtgca agcttcatag ctgaaaaacg
    13081 tgaagagtat aagaaagata ttgatattta tcatttagca tcagagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gttaaaaggg cgtttcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa gtcaaggagg ggaaaacatt gaaacaagca gtttggtttc
    13321 caacagaaga gtataaggaa aaaacacgtt tatatggttg gatgaaatca ttgggatatg
    13381 aagactatga aactttttat aataaatcta ttgaggaaac agcttggttt tggggagagg
    13441 cagaaaaagc agttggctat caatggatga aaccttatac agaagtgtta gatttagaaa
    13501 atggtacgcc atttgcacag tggtataatg atggaacatg taacgttgta gaatcagctt
    13561 tatcccgctg gattgcggat gaagtgacaa gaaaacagcc agcacttcag tacgaagggg
    13621 aaaatggaac ttcaaaatca tttacatatg aagagcttga caattgggta agccgtgtgg
    13681 ccaatggttt gaaacaagcg ggtattgaga agggcgatcg tgtaacaatt tatatgccga
    13741 tgattccgga aacagttgtt gcgatgctag ctgtaatgaa aatcggagca attatttcac
    13801 caatattttc gggatttgct tcggatgcag ttatgacacg cgtacaagca gctggttcaa
    13861 aaatgattat taccgcagat ggattttcac gccgcgggaa aattgtttct ttaaaggatg
    13921 aagtagataa agcttgtgaa cattgcccga ctgttgaaaa ggtggtaatt gttcgtcatg
    13981 caggaaataa ttttacaccg catcattatg acttttcatg gagtacgcta gaaaaagaaa
    14041 aaccattcat acatgccgaa gaaatgcata gtgatgatcc tttaatgctc atatatacat
    14101 caggaacgac tggtaagccg aaaggaacgg tacacacgca tgcaggattt cctttgaaag
    14161 cagcttttga tgcaggattt ggaatgaata ttaaacaagg tgatcgtgta ttatgggtaa
    14221 ctgatatggg ctggatgatg gggccatttt tattattcgg ttcactcata aatggtgcaa
    14281 cgatggttat gtacgaaggt gttccagact ttccagaagc agatcgctta tgggagacgg
    14341 ttgataaata tgaaattact catctcggta tttcgccaac gttaatccgt gcattaatgg
    14401 caaaaggtga tgagtatgtg aataaacatt ctttaaagag tttagaagta ttcgcatcaa
    14461 caggagagcc ttggaatcct gatccatgga tgtggctgtt tgaaacagtt ggaaaaggaa
    14521 aagtgccaat ctgtaactat tcaggcggaa ctgaaatttc tggtgggatt ttcggtaatg
    14581 ttctgattaa gccaatcgca ccaattagtt ttaacgcatc gttaccaggt atggctgcgg
    14641 ttgtacttga tgatcaaggt aaaccaatcc gtgatgaagt tggagaatta tgtttagaga
    14701 aaccttgggt tggaatgacg aaaagtttct gggaagacga tgagcgttat gtgaacacat
    14761 attggtcacg atttgaaaat aaatgggttc atggtgactg ggttatttat gatggtgaac
    14821 aatatatcat tacagggcgt tcagatgata cgctaaatat tgctggtaaa cgtattgggc
    14881 ctgctgaata tgagtctatt cttgtgaaac atattaatgt aatagaagca gcttccattg
    14941 gtgtacctga cgatgtaaaa ggtgaggttt gtcattgctt tgtagtatta cgagatggtg
    15001 taatatttac agcagaatta aagaaagaat taatgagttt agtaaattct catatcggaa
    15061 aagcattatg tccaaaggat atccacgttg tagcggattt gccaaaaaca cgtaattcta
    15121 aagtaatgcg acgcgtcatc aaagcggctt acttaggaaa agaattagga gatttatcat
    15181 cacttgtaaa tccagaagta gttccacata ttcagggtct acagtctagt aaattataaa
    15241 tgtaggaatg agctctatgt aaatggagct catttttcat gtttataaaa agagaagaag
    15301 taaatttgaa gtagtaaaat tctacttgta ttattacgac gtatgtttgt tttatagttt
    15361 ttatcaaaat aggattgtgg cgtgtctatt cattggagtg attgaattgt gttaaggatg
    15421 aaaatttagt gaagcgaaaa gtaatgaata aaaggagaaa tccctggggg acagggattc
    15481 actaagggag atagtattgt cgtgcgatgt cgaaatttgg cgtattcgac aaattaatat
    15541 tatcacgaat tttcaggaga ttgtaatagg gaatgtgtca aaaatgtgta cgtatttcct
    15601 attaaagtgt tatgtaaata ggaaaaggga aaaaattaag ttcactcgtt cttaagaatt
    15661 tttcccctta aaatttagta tttgttcgtt attctatata cgtcttaatt tggtaaatct
    15721 tcaacatgta aagattgagt attgcccttt ttgtttgaat tatgtgcctt ctgagatgtt
    15781 tcttgcattt gctcttgggc tttactagga gtattcagcg catcagatga tacatgatca
    15841 agttgttgac ttaataaatc ttttttatcc atgttatgta gctccttttt gaactttgat
    15901 ataaaaacga agtgttttta aatagttacg tgggtattat gtatctttga atggaattat
    15961 atacacaaac tacattgaga agttaactac ttataaaaat tacctgtgat gacaagctga
    16021 agaaatataa agatcattag tgattaataa aagcattatt ttagtagggt gttacgaaat
    16081 ttcatttaaa aagaacatcc caatgataaa aaagagcact gtaaatcagt gctcatctta
    16141 tcagaaactg cttagtcctt aaaaacaaaa ccattacgga caattcacaa tggtaatagt
    16201 gatgctagcc attgttccag gagaatcaag aagtgaagca gtaacggtta ctgttccagg
    16261 cccattagcg gctagaaata cagcggtaaa gttacctgaa gcattggtaa tgacagcaag
    16321 aggaaccatg aaagcaagag aagggttact aaatgaaaaa ctgaccacta cccctggagt
    16381 aggactaccg tttactaata cttgccccga aaaaaataaa gtattatttc cttgagtgga
    16441 tacacatgct gtggtttcgt tagaagtcaa ggtaatagat gcaggtccag caggaagatt
    16501 aaatccagtt ggtccggttg gtccagttgg tccggttgat ccggttggtc cagttgaacc
    16561 agtagctcct gtagaacctg tgggaccagt agggaattga aagggttgaa caggtggaag
    16621 tgtaggtcca atagaaccgg gattatgtgc aacaaaagat aaaaactcgt ccataattta
    16681 tcacctctaa aaattgtatt actattagta aatgtactga cagagcaaac tgaaatggac
    16741 aagcggttgt attttaataa attaaacaaa atagttattt gatagaaaga gagagtagta
    16801 tgattccttt agaaattaaa tataaaaagg cgattatctt caaatcgcct tttgggtaat
    16861 gcagtgtaat tttattcagt tatttgaaat atagtttcat tcggtttaga aaatccatac
    16921 aatttccttg cgaattttaa aatttcttct tcactacttg ttaaagcttt aacatcattc
    16981 ttaagggaat ggccatcctt ctttacagaa gataattttt gttgttccgt attcagcgtg
    17041 atttgttttt ctttaatcat ttcttgttgg ttattcagag aatattgaag gacaaaaatt
    17101 ataggtacca taatagccaa agtagttata atacggcgtc ttgttttttt tctattgcct
    17161 tgttgtgtat tagggttcac ttgctgtgag ggtatattag gacttgattg gtgtgatgat
    17221 acttttggga tgtttcccat taaaatgcct ccattactga ttgtagaatt taaaccgttt
    17281 aaaagtatta taaatgttta atgggaattt tagaagatat tttaatatag ttgcatatcg
    17341 taaagtttaa acaaaatcct tatttacata aaagaaacac cgattgtctg cgaggctcct
    17401 aaggataatc atcaagtaat gaagtactcg actaattaac gatatcacga atttttgggt
    17461 aaaaacactg aaaaatccgt ttaaattaat aggagtatca tttgaaataa aaacgctatt
    17521 ttaataggga agggaataat gatgattcca tgggataagc gagtatacat tgtatcaagg
    17581 tgatcatttt attacagagg ggacaattgt agaggttagt gaaaaggcaa ataaatcatt
    17641 atattggctc cagtgcatga tagctccaag ttatgaaaaa gtgtgcggga atagtataaa
    17701 gcgacttcgg ttgattcgga tagataatga cgaagaatga gatgattaag gataggtatt
    17761 gaatatgcca tatttgtatg aataaagagc agaatatagc caatatatag gtgctgaaat
    17821 tgttctaaag gtaggaatat ctgaaatata aataattgag gggagtgaac taaaaatgga
    17881 aactagcact tttttaggat tgttttgggg atggatcacg gttatcgtat cgggaatact
    17941 tttcgtacgc ccatcggtat tacgtgaatt gaaaaaatta gtggttgaag acagagggtt
    18001 tggtattatg tacggttttt tatcgatttt cctagggcta ggtactgtaa tcttacataa
    18061 tgtatgggca ttcaactggc aggggttcct aacggttatt gcatggcttg cattattaaa
    18121 gggaatttac ataattgcat atcctgaacc ctccaagaaa actgattttg aattaaggat
    18181 actatctaca cgtatagcgc tcgctatcat tggcgccttg gctttatgga tgcttatagt
    18241 aatctatata aaataatctt tttctaatga gaaatatact aaaatatgag aaaaggctat
    18301 aataataatt ataaatttag tcctactgga agaatccgtg gacatcaaac taaaaaggga
    18361 gttgttatat tactctgtag tttggtggcc acttttttat tttttattaa caaaatagat
    18421 cagggttatt tttataaatg acgcaattaa cttccgaatt aaaactgagc ggaaagaaat
    18481 gtatgtttgt tcgggagggg tgttaaagaa attattacaa ctgtgtaagg ttaatgtaat
    18541 attaatcgat agtaaatcaa gatacttaag tgtattttta ataggatttg aaagtactgt
    18601 ttttaacata ttgggttaaa taaaatttaa ttaggaagtg taatacaatg attgagatta
    18661 aatctatgat ttattcgtac aaactaaaaa gaagaatagc taaagattta tatggcagca
    18721 gagatgagtt gacgatgtta ttaaatgaat ttaataatat gaaaagtaaa ctgaagtctg
    18781 acaaaaagaa aaataatatg ttatctcgtt tacaattaat gtaccaaaat atgaaattag
    18841 acaagcagta ttctcttccg tttgctctta atagtaggtt attggagcga ttagaagatg
    18901 aatctattca aacaactgaa gaatgtgtat catgtctaca cgtaatgtta gaaataaatt
    18961 atgagaaaat acaacattat ggatctaata caagtaggtc atttgttcct ttatcacagt
    19021 cttccatttg tcttgctgat tttgtttgtt tgacaggatt tgttttatta ggcttactag
    19081 gaacaattac atttggaggg ataatgtaat ctttttattc acttacataa aagaccaccc
    19141 atttaaggtg tattttttag ttacatagaa gagctcatgc gatagacagg gaagaatgac
    19201 acggatgcta atttctagtt gctcattgtt aatgcattgt gtaactagaa agataaaatg
    19261 ttatgatgct atgaataaca aggaatttag cgtttgggct agttacacaa aatataagat
    19321 atgggtaact cataataaac gtgaaatgat aaaccctatg ttgtcgcagc gattaagtga
    19381 gtatgctgag ggtttgttat tgatgcaaaa ttaagtgtta caggacttaa ttttgcatca
    19441 ataacaaaag gaaaacttac tactgtaaat aaagtgtatg tgaaataatt acaaagtcga
    19501 tttataagag tcagcttata tttcgacact ccactcaact tgtaactata gatggcagta
    19561 taaatcttta tgtgttaata tacaaaaagc cgactatact cagtcagctt tttgtatatt
    19621 atattctagt atttatcgat cccaaaagac atattctttc cgttaagttg acattaaaat
    19681 cttaccaatg ttttctttta caatgacaac aaataaagaa acatttacaa cgacacttat
    19741 ttcgtttaga actccaatca tcatcacaat gatgcttttc tttagatttc caccaatcat
    19801 cattacaatg cttttcctta gaactccaat catcatcaca atgatgcttt tctttagact
    19861 tccaccagtc atcacaacaa tgctgtttct tagaactcca gcaatcatta ttccaggaca
    19921 tttttttata cctcccttca ataggattac tatcattcta tgttttagtg aagaaatggc
    19981 ttgtttataa acctattatt ttatctttat atgatagagt gctttctact acatatagaa
    20041 ttcataaaaa ctatgctaat ttccaagaga tagtggagag aattactggt tatgacattt
    20101 atcaataaac acatgttgaa gaaaacattc tgattataaa taatatctta ttttggagta
    20161 cgtttttctg aatgtatatt tcaaaacagc ggagaaaaaa tatactatat tgctacaaac
    20221 aaagcctatg tatatgtaaa gtaataggaa aaacagctaa ctcttaaagg ggctggctta
    20281 ttaaaagaaa aaaagattct tttgataaag aggttatcta aactttaaat tcagcagaat
    20341 taaatccaag tcccctcact aaacaagccg ctaactgtta aagaattgtt tttataatta
    20401 ataaagaaaa aaatgtttag tacaattgtt tgtttttttc tttctatgtg tttgcctcgt
    20461 acacttttaa gctagtggac atactctact aatagaaagg attagggggt gaggttttgg
    20521 gttctcgatt taataattgt aaaaagaaat gtacatgtaa acaggatgat tgttgggaga
    20581 tattcgaaga gtgtaaaaag gaaaagcatg agaaatgtga taattcttgt gtacaaggaa
    20641 ttagagatga gcttaagaaa ttaattaatc gaacagttca aattaataca gagggacgta
    20701 cttatgtagg tactgttgcg tctgtaagtt gcgatgtagt taagcttgca gctattcctg
    20761 gatctgttgc agtaattatc tccatttgca aaattgaagc aattttccct cctgttacaa
    20821 cgattactgc agagtttgat tttaatggtg ttgacgtagc aaataaagca taattatgct
    20881 ttgtttgtaa agccattctg atgaatggct ttattttaat ttcgtataaa aggagaatat
    20941 attctttata tagaaataag tttgaggcta taaagagtga tgtacgaaag gagaatgaga
    21001 gtgattaaat tagtgccctt taaaagatct gatttcaaac aattaataaa ttggattcat
    21061 tccgaacaat ttttaataca gtggtcagga aatgcattta catatccttt aaacgaacag
    21121 caattagaga aatatataga aagtgcaaat acactcgctt tcaaagtaat agatgaaaag
    21181 actgaagaag tacttggtca tatttcactt ggtcaaatag acgatataaa taagtctgcg
    21241 agaattggaa aagtgttagt tggtaatacg aaaatgagag ggcgttcaat aggaaaacat
    21301 atgatgaaag cagtacttca tattgcgttt gaagaattaa aactacatag agtaactctt
    21361 ggcgtgtatg attttaatac gtcggccatt tcttgttatg aaaaaatagg atttgtaaaa
    21421 gaaggtttat taagagattc aaaaaaagta ggagaaacgt attggaattt atgggaaatg
    21481 agtatgctag aatatgaatg gaataataaa aaataatagt ttcttataat tttattatgt
    21541 taattaaaag ggattggtgg gaaattatga atagaaagac tatagtaatc acaattgcag
    21601 ctgtttcagg gggaggtaaa actactatta cagaaagttt aactcatgag ttaacaaatt
    21661 caaaagcgct attttttgat agttataact ttgataactg tcctgctgat atttgtaaat
    21721 ggattgatga tggagcgaat tatgacgagt gggtacttac accattaatt catgatattc
    21781 agcatcttat acgagatagt aaattagact atattattgt agattatcct tttgcatact
    21841 taaatagaga aatggggcag ttcattgatg taactatatt tattgacaca cctttagata
    21901 ttgcaatggc tagaagaatt ttacgagatt ttaaagaaga tactatgagt gaaatacata
    21961 atgatttaaa acattacatg gcacatgcga gaaaagctta tttagaggca attcatactg
    22021 ttaaaccgaa ttcagatatc gtattggatg gatctttttc tgtaagtgaa ataattgatc
    22081 atgttgttga ggaacttgac cgaagagaag tgattgtcaa tggttaaatg tatagaggaa
    22141 tatgtacaag ttgatgattt taaaatgtat acgaaagtat ttcaaggaaa aaagcggcag
    22201 cctgttatta taatggaatc aggctacggg gattattcaa aggcatggga ttatattgct
    22261 gaaagactga cggaatttgg gacgatactt acatatgatc gagctggatt agggaaaagt
    22321 gggaagagtt tcaagcaacg tattagttct gaaatggtca aagatttaag aacatgttta
    22381 aatcttttac aactgaagcc accttatatt tttgtagggc attcttttgg tggtataaat
    22441 gcacggttat ttacggtttt ttatcccgag gatatgttgg gaacagtttt ggttgattcg
    22501 acaccagaaa attataaaga agtatttttg ccaatcatgt ctccagaatt tcaagaagct
    22561 tactataaac aatttgcata tgaaagttca tatgaagagt ttatgtttag tctaggtgaa
    22621 gcagatagac attgtaaatc aatgaacgat attccccttg tcgtgctagc tgctggtaaa
    22681 aaagcttttt attcgcaagc tgcacaactg aaatggttac aattacaaag agaattatta
    22741 caattatcca gtaaaagtaa atttataatt gcagaacata gcggtcacta tattcaaaag
    22801 gatgagccac attatattat aggtgctgtt aagtggatac ttggggtagg ggagagataa
    22861 atgtgtacac tgtatttcaa tataactggc aagtaagaga agattggttt aagtggtgtg
    22921 aacaacttac agtggaagaa ttacttcgca aatgtgttgg tggtgttgga agtatattag
    22981 aaacattatt tcatattgta gatgttgagt atagctggat ttgtgatttg aaaggaaaag
    23041 aagtagatga gccgcaattt aaggattatc aatctattca aaaagtgaaa gcattatctc
    23101 atttgtataa taaggattta gagggatttt tacaatcgtg gacagaagac ttagagaata
    23161 aaatattaaa agtttcatgg acggataaag agtacaagta tggtgaagtg ttacgacatg
    23221 ttgtcgtaca tgaaattcat catataggtc agctatcaat atgggcaaga gagttaaatc
    23281 ttcagcccgt ttcagcgaat ttaattggaa gaggattata gacgtaaaaa ccgacttgta
    23341 ctgtaaacgc aagtcggttt ttatatgtaa gaagatttct tagttgaaat cctcggattt
    23401 tctttgacgt aaatgtaaaa acattaaaat tgtaataatg aaaaagatca tcatcgtttg
    23461 tatgattaaa tttttaaact gtagcaatat tgcccaagat gtaagagtat ctttaaaagc
    23521 ttggagtgca gagtacgagg aaggttcaaa accgtactga agtaattttt ttgtttcaat
    23581 aaaagtagtg ttttcttcat cggattctaa tattactgaa ataagcctag tatctcctag
    23641 ttttgcagta ccgacaaaac tattattacc gttagttgaa aaactagttt gcaagccatc
    23701 aacaccttgg aatttaatgt tttcattgag ggaataaatc attttatttg tgttgaaaac
    23761 ttgaaaattt ttgaaggtaa attggtaaga ggttagtttc gtcatattca gtacattagg
    23821 gaaatctttt actaaatgcg ttgctagttt agctgcatct ttcgctgttg tattcgattg
    23881 tttatttgta tcttgattag ctccagtaga gtttagaaaa ggagatggct gtgataactg
    23941 tagctgtttt gctttttcat tcattaacgt tgtaaagtta tcttcattgc caccaatgtg
    24001 ttctgccagt gcgagtgcag aacgattatt tcctgttaaa agcaatgcat gaagtaaatc
    24061 acgaaccgtc gttttatcct ttgctgttac ttgcatagga gtcgtttccg cttggaataa
    24121 ttcgttactt atttttacgg attcatctaa ctgtattttg ccgtcattta gttgttccaa
    24181 tacgatatac tctgtcatta atttagacaa agtagctgat tgtatagggg tttcttcatt
    24241 ttttttataa ataacttcac ctgaattagc atctattaaa atagctgatt tagcttgaat
    24301 aattggacca tttacataaa gataaaaata taaaacgata agtgcagtaa taataaaaga
    24361 taataataaa attgtgaatt ttttcaagaa ttgcataagc gatcctccta ctatgacatc
    24421 aataataata ttgtaaaaag gaatgcttaa ttaggaagaa agaaaaggta aagaatttct
    24481 aaagaatttc taaagaatta taaaagatta ttaaactttg gatattgatg gaaaataaaa
    24541 ggttcaattt cttatcatat tagaaattga acctaaaatt atggtgtatt aatttttata
    24601 tggtagtagt tttacagtga aagttgtttt cttgtcatca ctatatactt caatcgttcc
    24661 tttatgcagt tcgacaatac tttttgcaat tgctaatccg agtcctgatc caccagtgtt
    24721 tgttgaacgt gatttttcaa cacgataaaa acgttcaaaa atatgaggta aatctgtact
    24781 aggaataggt tgtccgtaat ttgttatatc aattgtaatc atattattgc tttcataagc
    24841 ggtaaggtca atataaccac cttcgtttcc ataagcgata gcgtttataa taagattttc
    24901 aaatacacgc actaatttgt ctccatcagc taataccatg agtttttgag aggggaaaga
    24961 aggacggcat tgaatatttg cttcttgcac ttgtattcgg aattgaacag ttaattgtcc
    25021 aagtagctct acaatatcaa tgggagcaga atataaactt aactctttat tttgaacacg
    25081 ggtgtattca aacaagtcat tcattaatgc atttagacgt gttactttac cataaatgac
    25141 ttgtatgtaa tgacgtaatt ccacttcatc tctataatta tcatgatgga ttaaattcac
    25201 gtatccaact attgatgtaa ggggagtacg taaatcatg
//
