LOCUS       NZ_KB976303            15015 bp    DNA     linear   CON 14-JAN-2024
DEFINITION  Bacillus cereus K-5975c achrv-supercont1.2, whole genome shotgun
            sequence.
ACCESSION   NZ_KB976303
VERSION     NZ_KB976303.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus K-5975c
  ORGANISM  Bacillus cereus K-5975c
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 518567)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Bacillus cereus K-5975c
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 518567)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2012) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R38749
            Assembly Name                     :: Baci_cere_K-5975c_V1
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/14/2024 01:11:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,396
            CDSs (total)                      :: 6,275
            Genes (coding)                    :: 5,989
            CDSs (with protein)               :: 5,989
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 5, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 286
            CDSs (without protein)            :: 286
            Pseudo Genes (ambiguous residues) :: 0 of 286
            Pseudo Genes (frameshifted)       :: 113 of 286
            Pseudo Genes (incomplete)         :: 198 of 286
            Pseudo Genes (internal stop)      :: 95 of 286
            Pseudo Genes (multiple problems)  :: 94 of 286
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:03:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 15015
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB976303.1.
            Please be aware that the annotation is done automatically with
            little or no manual curation.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..15015
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..15015
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..15015
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1961:5015](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1962..5015
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            3..209
                     /locus_tag="IGY_RS26035"
                     /old_locus_tag="IGY_05183"
     CDS             3..209
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790340.1"
                     /locus_tag="IGY_RS26035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05183"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_000790337.1"
                     /transl_table=11
                     /translation="MKNISEKSVGLSMKKLDTTEMEKIYGASGVDTRTHPTVIVVSRAS
                     SKACMSGVSAISGLLSYNKDCIG"
     CDS_motif       3..83
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /locus_tag="IGY_RS26035_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       84..209
                     /prepeptide="core"
                     /locus_tag="IGY_RS26035_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3970.5"
                     /monoisotopic_mass="3968.1"
                     /core_sequence="SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /leader_location="[2:83](+)"
                     /alternative_weights="3988.5"
                     /alternative_weights="4006.6"
                     /alternative_weights="4024.6"
                     /alternative_weights="4042.6"
                     /alternative_weights="4060.6"
                     /alternative_weights="4078.6"
                     /alternative_weights="4096.7"
                     /alternative_weights="4114.7"
                     /alternative_weights="4132.7"
     gene            222..419
                     /locus_tag="IGY_RS26040"
                     /old_locus_tag="IGY_05184"
     CDS             222..419
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790339.1"
                     /locus_tag="IGY_RS26040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05184"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_000790339.1"
                     /transl_table=11
                     /translation="MKNISEKSVGLSMKKLDTTEMEKIYGASGVDTRTHPTVVVVSRAS
                     SKFCVTVVGSVLLSYNMDKC"
     CDS_motif       222..302
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /locus_tag="IGY_RS26040_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       303..419
                     /prepeptide="core"
                     /locus_tag="IGY_RS26040_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3863.4"
                     /monoisotopic_mass="3861.0"
                     /core_sequence="SGVDTRTHPTVVVVSRASSKFCVTVVGSVLLSYNMDKC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /leader_location="[221:302](+)"
                     /alternative_weights="3881.5"
                     /alternative_weights="3899.5"
                     /alternative_weights="3917.5"
                     /alternative_weights="3935.5"
                     /alternative_weights="3953.5"
                     /alternative_weights="3971.6"
                     /alternative_weights="3989.6"
                     /alternative_weights="4007.6"
     gene            449..655
                     /locus_tag="IGY_RS26045"
                     /old_locus_tag="IGY_05185"
     CDS             449..655
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790340.1"
                     /locus_tag="IGY_RS26045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05185"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_000790337.1"
                     /transl_table=11
                     /translation="MKNISEKSVGLSMKKLDTTEMEKIYGASGVDTRTHPTVIVVSRAS
                     SKACMSGVSAISGLLSYNKDCIG"
     CDS_motif       449..529
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /locus_tag="IGY_RS26045_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       530..655
                     /prepeptide="core"
                     /locus_tag="IGY_RS26045_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3970.5"
                     /monoisotopic_mass="3968.1"
                     /core_sequence="SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNISEKSVGLSMKKLDTTEMEKIYGA"
                     /leader_location="[448:529](+)"
                     /alternative_weights="3988.5"
                     /alternative_weights="4006.6"
                     /alternative_weights="4024.6"
                     /alternative_weights="4042.6"
                     /alternative_weights="4060.6"
                     /alternative_weights="4078.6"
                     /alternative_weights="4096.7"
                     /alternative_weights="4114.7"
                     /alternative_weights="4132.7"
     gene            668..>760
                     /locus_tag="IGY_RS34440"
                     /old_locus_tag="IGY_05186"
                     /pseudo=""
     CDS             668..>760
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000790340.1"
                     /locus_tag="IGY_RS34440"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05186"
                     /product="type 2 lantibiotic"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKNISEKSVGLSMKKLDTTEMEKIYGASGVD"
     assembly_gap    761..935
                     /estimated_length=175
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            960..1148
                     /locus_tag="IGY_RS26050"
                     /old_locus_tag="IGY_05187"
     CDS             960..1148
                     /GO_process="GO:0050830 - defense response to Gram-positive
                     bacterium [Evidence IEA]"
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016078397.1"
                     /locus_tag="IGY_RS26050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05187"
                     /product="mersacidin family lantibiotic"
                     /protein_id="WP_033669113.1"
                     /transl_table=11
                     /translation="MSTLKENVVGLSMKKLDTTEMEKIYGASGVDPRTTPSPLLASFVA
                     SYIASAQFRCGKDNKGK"
     CDS_motif       960..1040
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSTLKENVVGLSMKKLDTTEMEKIYGA"
                     /locus_tag="IGY_RS26050_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       1041..1148
                     /prepeptide="core"
                     /locus_tag="IGY_RS26050_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="3.30"
                     /molecular_weight="3544.0"
                     /monoisotopic_mass="3541.9"
                     /core_sequence="SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTLKENVVGLSMKKLDTTEMEKIYGA"
                     /leader_location="[959:1040](+)"
                     /alternative_weights="3562.0"
                     /alternative_weights="3580.0"
                     /alternative_weights="3598.0"
                     /alternative_weights="3616.1"
                     /alternative_weights="3634.1"
                     /alternative_weights="3652.1"
     gene            1236..1946
                     /locus_tag="IGY_RS26055"
                     /old_locus_tag="IGY_05188"
     CDS             1236..1946
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000821814.1"
                     /locus_tag="IGY_RS26055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05188"
                     /product="NAD(P)H-dependent oxidoreductase"
                     /protein_id="WP_000821815.1"
                     /transl_table=11
                     /translation="MKRILLYSGSRNNDSRTNKIINELKLHIEKYFSDIVLDIFDPISK
                     PLLHSTGCKNCFNRGICPSDGLEGDYGRELKEIVDSADLIIFATPVYSHNVSSDAKIFI
                     DRLSYWGHLLKLVSKPVITVVTAESNGGDLVEAYLYKIFSFMGATVVNSEVFLKTYSEE
                     YEESMSSLIESIETLKNNDFKVDINEKHEATYQTLKSIISRYPKDNFEYQYWLQNGLFD
                     SQTLKEHISKNFVY"
     gene            1962..5015
                     /locus_tag="IGY_RS26060"
                     /old_locus_tag="IGY_05189"
     CDS             1962..5015
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016078398.1"
                     /locus_tag="IGY_RS26060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05189"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_016078398.1"
                     /sec_met_domain="DUF4135 (E-value: 3.4e-100, bitscore:
                     330.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1e-39, bitscore:
                     131.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTNLHKSLNIRERYDLMSTYIKDSKEYNSDALSNWRTEMSILSD
                     EEFEQMLKYNDYKMNAFSFAVDKNPSEEINNLYKQKAKESQWYNTFIEIMENTDLNEVL
                     DPERAGMLFILRPFIDFVKKEISIFVSKHDYHSIVSQNILESLIEQFAISIAEVAQKSL
                     VLELNLDRENEFLVGTTPEDRFVFFVNQYKDKDKLIDFFDKYIVLTRLLSTITPNFISN
                     IKVLFNRIDKHKNDILQTFTIQDPLLLTDIKIGQGDTHNKGNTVIELIFNKNYKIIYKP
                     KNLEISKLYNEIIEYFNKKDDVLDMKIVKGIYEDDYSFEEFIPYEQCHNKVQLAHYYER
                     FGQVMAILYLLNASDMHLENLIANGEYPVAIDLETLFQQPIMHALDEYPILKKARLQMF
                     NNVVSTMLLPHGTRSDREDEVGIDLSALDGKGVKINKKILQPVNIGTDEMRYEHLEFKT
                     SDSNNIPYLETVNNKVGYKDYIIEIINGFRNVCSIALNNKNDLIELCNDSGNKIARVIV
                     RDTSQYGNILQHSHHPDLLQDMLDREKVLENMWTHSFSNKEIIKHEIEDMLINDIPIFF
                     NKIGTKDVISSNGELMLSIQQYDGKELVINKVNNLTEDEINKQVSVMNISFGLYPEKEQ
                     MQKQPKLLQQNTFGEFDLKEEAIRIADDILQNAIVEEDKIMWIAVNPEEGDKWSIGLID
                     DDFYDGLSGVYLFLHTLYVETQKEEYLDYANRVLKTLNHHVVKNELGMNSSSIGIMHAV
                     SRIKNKKLSRALREELKNQVNYIDDQEIDITHTDYLNGSISLINTLINIYENGKDANYL
                     SLAIKYAEKYIKLPIKEKINNDISFGHGYISIALVFFRLWKCTNNQRYYNLGGDFYNEF
                     YASFEEHKKEEFKDLNFSWCRGILGILIAELEIMNILDNEKHSSVVEALEPLLLNMDMS
                     GNDGLCHGNIAVTEYFLKKYEYSKNEEDLKMAQIIVQNIINRHNRENRFMLRYAKGFKS
                     IGLFTGLSGIGYQMLRVSNPEKIKSILD"
     gene            5038..7167
                     /locus_tag="IGY_RS26065"
                     /old_locus_tag="IGY_05190"
     CDS             5038..7167
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000708395.1"
                     /locus_tag="IGY_RS26065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05190"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000708396.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 9.6e-40, bitscore:
                     130.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIYKKRVKFVEQMESVECGLACFAMIANYHNIKLSLNNLRNLYP
                     APREGFSFLNIREIANNYSFSADAYEIDMAELTAISLPCIIQWGNNHFVVLERIKKQSY
                     IIVDPNRGKIEVPQDEFKQKYSGFALQFQFIGNTKNIIPKEKQENIILKYFKQHKGRFF
                     GLVFLSIIIQGLMTVIPLSTKWVTDNAFSNSDINKLNSFGWLIIIFSISFVLMSLLRGI
                     SIALLQKSLDLSIMNDFMKKMFHLPYSFFDNRSSGDLLFRANSAVFIRDIISTTMITIF
                     IDLLLIITYTAVMINFSLDLSLLLLSLSMLLAVILFVNANVIRKMTKKNIQDKVNTQAV
                     LTENMYNIVDIKSLGLEKKRLSLWSGNYSKELESSQRLNIFQAVIHTITGFFQVSVPLL
                     VLWVGGHALINGEITLGTLIAFSSIAGSYITPIVSVSNNYTQLISLGSYFSRIKDVLRT
                     KDEQEKSNVQAHSIKGDIKFENVNFKYNQFSKYILKDLNFTIKQGEKVAIVGPSGSGKS
                     SISKLLLALYKVSEGQILINNKNINDYDYHSLRTSIGTVLQESKLFSGSISDNISMSKD
                     NHDDLKVIDAAKKSGILEDILNSPMGFETIISESGNNFSGGQRQRLLVARALYQEPSAI
                     VFDEATSHLDLFTERHIENTLKELNITQIIIAHRLRTIQNADKIIYLEDGMIKEIGTHE
                     QLLKNRSYYYNLYSQ"
     gene            7220..8578
                     /locus_tag="IGY_RS26070"
                     /old_locus_tag="IGY_05191"
     CDS             7220..8578
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000285549.1"
                     /locus_tag="IGY_RS26070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05191"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_000285548.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.1e-34, bitscore:
                     113.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRFKKYCLSIISFILIISFFPNNTNATQIAYYSILIRDNTDFNT
                     VLDKLSKDNQEVVYSIPEVNLIQVKGEKGKIISGIGLESIEEINPSTGEFKTYTPNIND
                     QKGLDNKAIWDVQWDIKRITNNGESYKLHSPSGKVSVALIDSGYPENHPDIKSISIQNS
                     KNLVPKGGYKGNEENETGNIHQLTDRTGHGTSVLSQVNADGLMKGVAPGMPVNMYRVFG
                     ENSAEGSWIIKGIIEAAKDKNDVINISAGSYLLKNGTYSDGSGNNRAEIKAYEKAIHYA
                     NKKGSIVVSALGNDSINININSELLSILNSKIKDEGKSATGIVQDIPAQLAQVVSVAST
                     GMDSKVSSFSNYGKNIIDFTAPGGDIKLLNKFGADVWMAEEMFKKEMILVAHPQGGYYF
                     NYGNSLATPKVSGALALVIDKYGYKNKPNKAINHLKRNTNAENEIDLYKALQE"
     gene            complement(9135..>9427)
                     /locus_tag="IGY_RS34950"
                     /pseudo=""
     CDS             complement(9135..>9427)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000515998.1"
                     /locus_tag="IGY_RS34950"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing N-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="DUF4352 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="QGVFKVLEVTLQITKKTLSQLMLTTLNL"
     gene            complement(<9443..9763)
                     /locus_tag="IGY_RS34955"
                     /pseudo=""
     CDS             complement(<9443..9763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001053918.1"
                     /locus_tag="IGY_RS34955"
                     /note="internal stop; incomplete; partial in the middle of
                     a contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="IS4 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTLSILDELQPIAEKLQRHMSSHIL"
     gene            10173..11786
                     /locus_tag="IGY_RS26075"
                     /old_locus_tag="IGY_05192"
     CDS             10173..11786
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002196671.1"
                     /locus_tag="IGY_RS26075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05192"
                     /product="S-layer homology domain-containing protein"
                     /protein_id="WP_016078399.1"
                     /transl_table=11
                     /translation="MNIKFNKKVVAFTAGLTVLSSPLVSFAEEQQSVNNKQSTGLQVQG
                     NTDQLQTTDEQALKSIEASFEEVDGRGGGTVDNKKVDSLQRSEGIHEETGTLTVPNNSN
                     RTKRSLSPISPSTSSTINGVPFSEWIVPAGNDNIRPQNYMSPKYITIHETDNTSVGAGA
                     RNHAQYLYNQAVGNTDRAASWHFTVDDKEIYQHLPLNENGWHAGDGDGPGNRESIAIEI
                     AVNSDGNYSKAVDNAKKLVAYLMKETGVPLNNIVKHQKWSGKICPANMINNGQWDVFVN
                     SVEGYYNNLYQPKDDITGGWYEEAIRELNRRGIMIGEGNGVFAPNRAITRAEFAQLISK
                     SLNLPAGDASFKDLNDANSTLRDGIKRTASAGIIQGRGDGYFDPNTPITREESAIIVNK
                     ALQYKGIWGPVVNLPFSDKDQISYKEDVQRLYGLGIVKGKGENQYDPKGTTTRGETATF
                     ILNMLQVIENGSVEKVVGTAQINGIGVNVRSGSGTNYSIVRKTSKGEKVTVYEEKNGWL
                     RIGTGQWIYYDSSYIDYNRL"
     CDS             complement(12212..12337)
                     /gene="allorf_012212_012337"
                     /locus_tag="allorf_012212_012337"
                     /protein_id="allorf_012212_012337"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MFHLFILSKKELVVMPTSSFCIFYHFNQGDTYQNEGESNDD"
     CDS_motif       complement(12284..12337)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFHLFILSKKELVVMPTS"
                     /locus_tag="allorf_012212_012337_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12212..12283)
                     /prepeptide="core"
                     /locus_tag="allorf_012212_012337_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.80"
                     /molecular_weight="2676.7"
                     /monoisotopic_mass="2675.1"
                     /core_sequence="SFCIFYHFNQGDTYQNEGESNDD"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFHLFILSKKELVVMPTS"
                     /leader_location="[12283:12337](-)"
                     /alternative_weights="2694.7"
                     /alternative_weights="2712.7"
     CDS             complement(12390..12482)
                     /gene="allorf_012390_012482"
                     /locus_tag="allorf_012390_012482"
                     /protein_id="allorf_012390_012482"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MEFLTNRDEISFANSRNFHTLKRCMLIFVI"
     CDS_motif       complement(12444..12482)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEFLTNRDEISFA"
                     /locus_tag="allorf_012390_012482_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12390..12443)
                     /prepeptide="core"
                     /locus_tag="allorf_012390_012482_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.60"
                     /molecular_weight="2056.5"
                     /monoisotopic_mass="2055.1"
                     /core_sequence="NSRNFHTLKRCMLIFVI"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEFLTNRDEISFA"
                     /leader_location="[12443:12482](-)"
                     /alternative_weights="2074.5"
     misc_feature    complement(12426..12441)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.53"
                     /tool="antismash"
     misc_feature    complement(12834..12847)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            12937..13863
                     /locus_tag="IGY_RS26080"
                     /old_locus_tag="IGY_05193"
     CDS             12937..13863
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016090593.1"
                     /locus_tag="IGY_RS26080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_05193"
                     /product="hypothetical protein"
                     /protein_id="WP_016078400.1"
                     /transl_table=11
                     /translation="MKFNTKLLKKLLVLSATSVSIFSACSAKEDGDYKPYKEQDSIEVA
                     KVEEEKSNPPKIVEKKSTLPKVKEDTEEPKKKKRLQQVEESKNKDEEINEKYPHYKDVH
                     EDASTVSLEQYNQIKVGMPADKVIEIAGKPGSSETTKLFSIYIYLGHGGHGSMTIKFDS
                     NRNVTNKEQDGLSNTAVKDEKASKEHEDPNPESVKKSSAIIPNDFCGHGHDETKELAHD
                     CEKITDKKAYRRYQLQQKREERKRQIRGEEQELIDYDQGDAAYKEQQRIYEEIQRRTEE
                     RESIDYDYDQIRAVNKERQRMYEEIQE"
     CDS             14304..14375
                     /gene="allorf_014304_014375"
                     /locus_tag="allorf_014304_014375"
                     /protein_id="allorf_014304_014375"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MHIFNRLEEVLFMLFSSCRWDYL"
     CDS_motif       14304..14342
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MHIFNRLEEVLFM"
                     /locus_tag="allorf_014304_014375_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14343..14375
                     /prepeptide="core"
                     /locus_tag="allorf_014304_014375_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.20"
                     /molecular_weight="1253.4"
                     /monoisotopic_mass="1252.6"
                     /core_sequence="LFSSCRWDYL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MHIFNRLEEVLFM"
                     /leader_location="[14303:14342](+)"
                     /alternative_weights="1271.4"
     CDS             14456..14554
                     /gene="allorf_014456_014554"
                     /locus_tag="allorf_014456_014554"
                     /protein_id="allorf_014456_014554"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MIDIDKLLGSANEELRYKSCDGSLYRGKGRTK"
     CDS_motif       14456..14485
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIDIDKLLGS"
                     /locus_tag="allorf_014456_014554_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14486..14554
                     /prepeptide="core"
                     /locus_tag="allorf_014456_014554_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="2477.7"
                     /monoisotopic_mass="2476.3"
                     /core_sequence="ANEELRYKSCDGSLYRGKGRTK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIDIDKLLGS"
                     /leader_location="[14455:14485](+)"
                     /alternative_weights="2495.8"
                     /alternative_weights="2513.8"
ORIGIN
        1 aaatgaagaa tattagtgaa aaatcagtag gtctaagtat gaaaaaactt gatacaacag
       61 aaatggaaaa aatatatggt gcatcaggtg tagatacgag aacacatcca acagttattg
      121 tagtttctag agcaagcagt aaagcatgta tgtcaggagt ctcagcaatt agcggattac
      181 tatcttacaa taaagattgt ataggataag gagtgcttgg aatgaagaat attagtgaaa
      241 aatcagtagg tctaagtatg aaaaaacttg atacaacaga aatggaaaaa atatatggtg
      301 catcgggtgt ggatacaaga acacatccga cagttgttgt agtttctagg gcaagcagta
      361 aattctgtgt gacagtagta ggtagcgtat tattatctta caatatggat aaatgttaat
      421 aatataataa taataagggg tgtttgaaat gaagaatatt agtgaaaaat cagtaggtct
      481 aagtatgaaa aaacttgata caacagaaat ggaaaaaatt tatggcgcat cgggtgtgga
      541 tacaagaaca catccaacgg ttattgtagt ttctagagca agcagtaaag catgtatgtc
      601 aggagtctca gcaattagtg ggttactatc ttacaataaa gattgtatag gataaggagt
      661 gcttgaaatg aagaatatta gtgaaaaatc agtaggtcta agtatgaaaa aacttgatac
      721 aacagaaatg gaaaaaatat atggtgcatc aggtgtagat nnnnnnnnnn nnnnnnnnnn
      781 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      841 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
      901 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnatatt aggaagagag ggttatagca
      961 tgagtacctt aaaagaaaat gtagtaggtc taagtatgaa aaaacttgat acaacagaaa
     1021 tggaaaaaat atatggtgca tcaggtgtag atccaagaac gactccgtcc ccacttctcg
     1081 caagctttgt tgcttcgtat attgcatctg cacaatttag atgtggaaaa gacaataaag
     1141 gaaaataaag ataaaaatag aatgagaaaa tacttttatt ctctcattct attttctcat
     1201 tctattttta tataaatatt ttaaggggtg ctaaagtgaa gaggatatta ctctattccg
     1261 ggtctagaaa taatgactct cgtacaaata aaattataaa tgaattaaaa ctacatatag
     1321 aaaaatattt ttcagatatt gtattagata tttttgaccc cataagtaaa cctttactgc
     1381 attcaacagg ttgtaaaaac tgttttaata gggggatctg tccatcagat ggattagagg
     1441 gtgattatgg cagagaatta aaggaaattg tagacagtgc agatttaatt atttttgcta
     1501 ctcctgttta ttcccataat gtatcatccg acgctaaaat ttttattgat cgcttatcgt
     1561 attgggggca tttattaaag ttagtgagta aacctgtaat aactgtagta actgcggaga
     1621 gtaatggcgg agatttagtt gaagcttatt tatataaaat tttttctttt atgggagcga
     1681 cagtagttaa ctcagaagta tttttaaaaa catattcaga agagtatgaa gaatcgatgt
     1741 ctagtttaat cgaaagtata gaaacattaa aaaataatga ttttaaggtt gatataaatg
     1801 aaaagcatga agccacatac caaacgttga agtctataat tagtagatat cctaaagata
     1861 attttgaata tcaatattgg ttacaaaatg gattattcga tagccagacg ctgaaagagc
     1921 atataagcaa aaattttgtt tactaaaaag gagagaattg tatgttaaca aatttacata
     1981 aatcactaaa tataagagag cgttatgact taatgagtac atacattaag gattctaagg
     2041 aatataattc tgatgcttta tcaaattggc gaacagaaat gagcatttta tcagatgaag
     2101 agtttgaaca aatgttaaaa tataacgatt ataaaatgaa tgctttttca tttgctgttg
     2161 ataagaatcc atctgaagaa atcaataatt tatacaaaca aaaagctaaa gaatcacagt
     2221 ggtataatac atttatagaa attatggaga acacagatct taatgaagtc ttagatcctg
     2281 aaagagcagg tatgttattt attttaaggc catttataga ttttgtaaaa aaagaaataa
     2341 gtatatttgt ttctaaacat gactatcata gtatagtttc ccaaaatatt ttagaaagct
     2401 taatagaaca atttgctatt tctatagcag aagtagcaca aaaatcatta gtcttagaat
     2461 taaatttaga cagagagaat gagttccttg ttgggactac tcctgaagat aggtttgtat
     2521 tttttgttaa tcaatataaa gataaagata aattaattga tttttttgat aagtatattg
     2581 tgttgacgcg ccttttaagt acaatcactc ctaattttat tagtaatatt aaagtactat
     2641 ttaacaggat agataaacat aaaaatgata tattacaaac ttttacaatt caggatccac
     2701 tgctgttaac agatataaaa atagggcaag gagatactca taataaaggt aatacagtta
     2761 tagaattaat attcaataaa aattataaaa ttatctacaa acctaaaaac ttagaaataa
     2821 gcaaattgta taacgagatc attgaatatt tcaataaaaa agacgatgta ttagatatga
     2881 aaattgttaa agggatatat gaagatgatt attctttcga agagtttatc ccttatgaac
     2941 agtgtcataa taaggttcaa ttagctcatt attacgaaag atttggacaa gtaatggcta
     3001 ttttatattt actaaatgct tcagacatgc acttagaaaa tttgattgcg aatggtgaat
     3061 atccagtagc aatagactta gaaacactgt tccagcaacc tataatgcac gctcttgatg
     3121 aatatccaat tttaaaaaaa gcaaggctgc aaatgtttaa taatgtcgta tcaacaatgt
     3181 tgttaccaca tggtaccaga agtgatagag aagatgaagt gggtatagat cttagtgcat
     3241 tagatggtaa aggagtaaaa attaataaaa aaatactaca accggtcaat attggtacag
     3301 atgaaatgag atatgagcac ttagaattta aaaccagtga ttcaaataac attccatacc
     3361 tagagactgt aaataataaa gtaggatata aggattacat tattgaaata ataaatggct
     3421 ttagaaatgt atgtagcatc gcattgaata ataaaaatga tttaattgag ttatgtaatg
     3481 attctggaaa taaaattgct agagttattg taagggatac tagtcaatac ggaaatatac
     3541 tccagcattc gcatcatcca gatttactgc aggacatgtt agatagagaa aaagttttag
     3601 aaaatatgtg gacccactca tttagtaata aagaaattat taagcatgaa atagaagaca
     3661 tgctgattaa tgatatacca atattcttca ataaaattgg tacaaaagat gttatttcaa
     3721 gtaacggtga attaatgcta tcaattcaac aatacgatgg gaaagaactc gtaattaata
     3781 aggtgaataa tttaacagaa gatgagatta ataagcaagt ttcagtaatg aacatatcgt
     3841 tcggattata tccagaaaaa gaacaaatgc agaagcaacc taaattatta caacaaaata
     3901 catttgggga atttgattta aaagaagaag caataagaat agcagatgat attttacaaa
     3961 atgctattgt agaagaagat aagattatgt ggatagcggt caatcccgaa gaaggtgaca
     4021 aatggtcaat tggattaata gatgatgatt tttatgatgg tttatcgggt gtatatctat
     4081 ttttacacac attgtatgtg gagacacaaa aagaggaata tttagattat gcgaataggg
     4141 tattaaaaac cttaaatcat catgttgtta aaaatgaatt ggggatgaac agtagttcaa
     4201 ttggtataat gcatgcggta tcgagaataa aaaataagaa actatctaga gcattaagag
     4261 aagaattaaa aaatcaagtt aattatatag acgatcaaga aattgatata acacatactg
     4321 attatttgaa tggatctatt agcttaatta atacattaat caatatttat gaaaatggta
     4381 aagatgcaaa ttatctatct ttagcaataa aatatgctga aaaatatatt aaacttccta
     4441 tcaaagaaaa aattaataat gatattagtt ttggtcatgg atatatatcc attgctttag
     4501 tattttttag actgtggaaa tgtacaaata accagcgtta ctacaatttg ggtggagatt
     4561 tttataatga attttatgct tcatttgaag agcataaaaa ggaagaattt aaagatctaa
     4621 acttctcttg gtgtagaggt atattgggaa ttctaattgc tgaattagaa atcatgaata
     4681 tactggataa cgaaaaacat agtagcgtgg tagaagcatt agaaccgttg ttattgaata
     4741 tggatatgtc tggtaatgat ggtctttgtc atgggaatat agcagttaca gaatatttcc
     4801 ttaagaaata tgaatacagt aaaaatgaag aagatttaaa aatggctcaa attatagtgc
     4861 aaaatattat aaacaggcat aatcgcgaaa atagatttat gttgagatat gcaaaagggt
     4921 ttaaatctat aggattattt acaggattgt ctggtattgg atatcaaatg ttaagagtaa
     4981 gcaatcctga aaagataaaa tctattttag attaatgaaa aataagaagg gttatacatg
     5041 aaaatataca aaaaaagagt aaaatttgtt gagcagatgg agagtgtaga gtgtggattg
     5101 gcatgctttg ctatgattgc aaactatcat aatattaaac tctctttaaa taatctaaga
     5161 aatctttatc ctgcacctag ggaaggattt tcgtttttaa atattcggga aatcgctaat
     5221 aactattctt ttagtgcaga tgcatatgaa attgatatgg ctgaattaac tgcaatttca
     5281 ttgccgtgta ttatacaatg gggaaataac cactttgtgg tattagaaag aataaaaaaa
     5341 caatcgtata taatagttga tcctaatcgt gggaaaattg aagtaccgca agatgagttt
     5401 aagcaaaaat attctggatt tgcattgcag tttcaattta taggaaatac taaaaatatt
     5461 attccaaaag aaaaacaaga gaatataatt ttaaaatact ttaagcagca taaaggtaga
     5521 ttttttggtt tagtttttct atctattatt attcaaggtt taatgacagt tatcccactt
     5581 agtactaagt gggtaactga caacgctttt tctaattcag atataaataa actaaattca
     5641 tttggttggt taataattat tttttcaatt tcctttgttc ttatgtcact gttaagaggc
     5701 attagtattg ctttactgca aaaaagccta gatttatcaa taatgaatga ctttatgaaa
     5761 aaaatgtttc atttacctta ttcatttttt gataatagaa gtagtggaga tttattattt
     5821 agagcaaact ctgcggtatt tattagagat ataatttcta cgacaatgat tacgattttt
     5881 attgatttgt tacttataat tacatacaca gcagtaatga ttaatttctc tttagactta
     5941 agtttattat tgttatcttt aagtatgtta ttagctgtaa tattgtttgt taatgcaaat
     6001 gttattcgga aaatgacaaa aaaaaatatc caggataaag ttaatactca agctgtttta
     6061 actgagaata tgtacaatat tgtcgatata aagagccttg gactcgaaaa aaaacgctta
     6121 tccctttggt cggggaatta ttctaaagaa ttagaaagct ctcaaagact aaatatattt
     6181 caagcagtga ttcacacgat tactggtttt ttccaagttt ctgttccatt acttgtatta
     6241 tgggtaggag gtcatgcttt aatcaatgga gaaataactt tagggacttt aatagccttt
     6301 agttctattg caggatctta tattacccct atagtttctg tgagtaataa ttatactcaa
     6361 ctaatttctt taggaagtta tttttctaga attaaagatg tgctaagaac aaaagatgag
     6421 caagaaaaaa gtaatgttca agcccatagc attaagggtg atatcaaatt tgaaaatgta
     6481 aattttaaat ataatcaatt tagtaaatat atcctgaagg atttgaattt tactattaaa
     6541 caaggtgaaa aagttgcaat tgttggtccg tcaggatcgg ggaaaagttc aatttccaag
     6601 ttactacttg cattatataa agttagtgag gggcaaatat taattaataa taaaaatatt
     6661 aatgactatg attatcatag tttgcgaacg tctattggta cagtgcttca agaatctaaa
     6721 ctattttcag gatctattag tgataatatt tctatgtcaa aagacaatca tgatgaccta
     6781 aaagtaattg atgcagctaa aaagtcaggt attttagaag acatcttaaa ctctccgatg
     6841 gggtttgaaa ctattatatc agagagtggt aataactttt ctggtggaca aagacaacgt
     6901 cttctagtgg cacgtgcatt gtaccaagaa ccaagtgcta ttgtatttga tgaagctact
     6961 agtcaccttg atttatttac agaaaggcac atagaaaata ccttaaaaga gttaaatatc
     7021 actcagataa tcattgctca tagattaaga acaattcaaa atgcagacaa aataatatat
     7081 ttagaggatg gaatgattaa agaaataggg acacatgaac aattgctaaa aaacagatca
     7141 tattattata atttatattc acaataatta gtacattcta ttagaaatgt ctgtgaggtc
     7201 ttgataatag gaggataaaa tgtatcgttt taaaaaatat tgtttaagta ttattagttt
     7261 tatattaatt atcagttttt ttccgaataa taccaatgca acgcaaatag cttattactc
     7321 cattctaata agggataata cggatttcaa tacagtatta gacaagttaa gtaaagataa
     7381 tcaagaagtt gtttattcta taccagaggt caatttaata caagttaaag gggaaaaggg
     7441 caaaattata tctggtattg gtttagaaag tattgaagaa attaatccat ctaccggaga
     7501 atttaaaaca tacacaccaa atattaatga tcaaaaaggt ttagataata aagctatctg
     7561 ggatgtacaa tgggatataa agcgaattac aaataatggg gagagttata aacttcattc
     7621 tccatcaggt aaagtatcag tggcactcat tgattcaggc tatccagaaa atcatcccga
     7681 tattaaaagt atctccattc aaaactctaa aaatcttgta ccaaaaggag gatacaaagg
     7741 gaacgaagaa aatgaaacag gaaatattca tcaattaaca gatcgaacgg gtcacggaac
     7801 gagtgttctg agtcaagtga atgctgacgg attaatgaaa ggtgtagcac ctggtatgcc
     7861 tgttaatatg tatagggtgt ttggagaaaa ttcggcagaa ggttcttgga taataaaagg
     7921 tattattgag gcagcgaaag ataaaaatga tgttattaac ataagtgctg gatcttactt
     7981 gctgaaaaat ggaacttatt ccgatggtag tggtaataat agagctgaaa ttaaagcata
     8041 tgaaaaggct attcattatg caaataaaaa aggaagcatt gtggttagtg ctttaggaaa
     8101 tgattcaata aatattaata ttaatagtga attgttaagc atcttaaata gcaaaataaa
     8161 agatgagggg aagtcagcaa caggaatagt acaagatata ccggctcagt tagcccaagt
     8221 tgtttctgtt gcttcaacag gaatggattc gaaagtttct tcattttcaa attatggtaa
     8281 gaatataata gattttactg ctcctggtgg tgatatcaaa ttattaaata aatttggtgc
     8341 agatgtatgg atggcagagg agatgtttaa aaaagaaatg attcttgttg cccatcctca
     8401 gggaggatat tattttaatt atgggaattc acttgcaaca cctaaagtgt caggtgcttt
     8461 ggcgttagtg atagataaat atggttataa aaataaacct aataaagcca ttaatcacct
     8521 aaagagaaat acaaatgcag aaaatgaaat agacttgtat aaggcactcc aagaataaag
     8581 tgcgggcgcg aatatatcat gttttgctta ataagatgat gattctgttc cacaatgata
     8641 tatagatatt atagttataa gaaaagggtg cctattggca tccttttctt tgttaatctg
     8701 caattagtat gagctagatg gctggcaaaa tcttagtaga gactaagact aaagttaatt
     8761 ctttagatat aagttagata tctgctttca ttttattttt ttcttgaaat gtcaaggcgt
     8821 taaattttca tcattttagc caagaagact ccttcctcca ggaacatcaa ggatcataac
     8881 taagtaagta gagggactgg tttctgatag tgggtgaagg agactatctg aattatatac
     8941 tcaatgaaac attgaaatat ctttaaaaaa gtataataaa tgtaaaaata aagggaaacc
     9001 ctgatgttat aaaaaaacag caggcttttc ctattgagta ttcgtttact atctcattgt
     9061 acaaacgtga atttgtattg aaatcatagt gtgttttttt caataaaagc ccttaaaagg
     9121 gtgcttttaa ctattcaact tttaatttct ttacccatca tatcaccact agtttttaat
     9181 ataaaacctt tggcatcttt ggatacatca aatacaattt tacctgtttg tgttagacta
     9241 ggactcaatt attttaagaa aaagtcagtt tttccgccgt tagctaggtc aaaagatgtt
     9301 tgtccttatg tcaaatatgt gaattcacgg cctttgctat ttacaaattt aaagttgtta
     9361 gcatcaactg tgatagcgtc tttttggtta tttgtaatgt aacttctaaa actttaaaga
     9421 caccttgcat ttcttttgtt caatgaattc tttgagttag aaagtttact agaacttttt
     9481 caagaaactg tactgcggaa gcattaaacc gttgattaag ttcttcagga ttgataagaa
     9541 tacctgtaga tacatcaagg cagctactta attttgtgag cgatgtactt gcaacctgtt
     9601 gactaagtca taaacataga gcaactaact cctgtgcttg atatttaatt tttcgttgta
     9661 caaatccttt ttctttggat aggtgttata gaatatgaga agacatatgc cgctgtaatt
     9721 tttcagcaat cggttgaagt tcgtcaagaa ttgaaagagt cataaagcaa aaatacgcca
     9781 tcctttccta taattctaca aaaaggataa cgtatttttg ctttatgggt agtgtaaaac
     9841 cttagattga tagcgatgtg ataatgcccc catttaaaca aatttttctt ttccatactg
     9901 ataatgcccc tttttagatt catactatca gtatgtccaa gattaggaga ttacttgtaa
     9961 gagtcttgga attattgcaa ccgtgttgtg ttataattct aaagtactga catttcaagt
    10021 agggcttata gatgtcggtt tgtcatatgg aatgtaaaac caaccgttat tttaagggtt
    10081 caggctacca atatttaaac tattattcgc actaaaagaa gtacaaggag gaaggtatat
    10141 ctattaagat agtgagatat accaaattag aaatgaacat taaatttaat aaaaaagtag
    10201 tagcattcac ggcaggatta acggtattat cttcaccatt ggtatcgttt gcagaggaac
    10261 aacaatcagt aaacaataag caatctacag gccttcaagt gcaaggtaac acagaccaac
    10321 ttcaaacaac agatgaacag gctttaaaaa gtattgaagc tagttttgaa gaggtagacg
    10381 gacgtggtgg aggtactgtc gacaataaga aagtagatag tcttcaacgt tcagaaggta
    10441 ttcatgaaga aacaggtaca ttaactgttc ctaacaattc aaacagaaca aaacgtagtc
    10501 tgtctcccat atcacctagc acctctagta caataaacgg tgttccattc agtgaatgga
    10561 ttgttccagc aggtaacgat aatattcgtc ctcaaaacta catgagtcca aagtatatta
    10621 caattcatga gactgataat acaagtgtag gagcaggtgc tagaaaccat gctcaatacc
    10681 tatataacca agcagtaggt aacacggacc gagctgcatc gtggcatttt acagtagacg
    10741 ataaagagat ttatcaacat ctaccattaa acgagaacgg atggcacgca ggagacggtg
    10801 atggtccagg taatagagaa tctattgcaa ttgaaatcgc agttaacagt gacggaaact
    10861 acagtaaagc agtagataac gctaagaaac ttgtagctta tttaatgaaa gaaactggtg
    10921 taccgttaaa taacattgta aaacaccaaa aatggagcgg taaaatctgc cctgctaaca
    10981 tgattaataa tgggcaatgg gatgtattcg taaatagcgt tgagggatat tataataatc
    11041 tttatcaacc aaaagatgac attacaggag gttggtatga agaagctatt cgagagttaa
    11101 atagaagggg tattatgata ggggaaggaa acggagtttt cgcacccaat agagcaataa
    11161 caagagccga atttgctcaa ttaatctcta aatctctaaa cctgccagct ggagatgctt
    11221 catttaaaga cctaaacgat gcaaattcaa ctttacgaga tggtattaaa cgtactgcaa
    11281 gtgcaggtat cattcaaggt agaggagatg gttattttga cccaaacaca cctattacaa
    11341 gagaagaatc agcaattatt gtaaacaagg ctttacagta taaaggtata tggggaccag
    11401 ttgtaaacct accattctca gacaaagacc aaattagcta taaagaagat gtacaaagat
    11461 tgtatggctt aggtattgtc aaaggtaagg gtgaaaatca atacgaccct aaaggaacaa
    11521 caactcgtgg tgaaacagca acattcattc taaatatgct acaagtaatt gaaaatggca
    11581 gtgttgaaaa ggtagttgga acggctcaaa ttaatggtat tggggtaaat gttcgaagcg
    11641 ggtcaggtac aaattattct attgttagaa agacaagtaa aggcgaaaaa gttacagtat
    11701 atgaagaaaa gaatggttgg ctaagaattg gaacaggtca gtggatttat tatgactcta
    11761 gttatatcga ttataacaga ttataaaaga ctaaatactt aaaagaacag gtcatatttg
    11821 gatatataac ttactctcag gttgtgaaga agactttctt cacaacctgt ttttgtgact
    11881 agcccctcta ttacctatca atactgatga aaagaggaga aggagaaatt cattatggtg
    11941 ctggaattgg gaaatcatcg taattagcgt gtatgcaatt agaggctaag gtttttctga
    12001 taattaagtg gaggtcacta tacgtaccca tccagcccat attttgaaat attttaaaac
    12061 gaaaaaatga gctggatggg taaaagttag cacaaaattt cgttctgagg gtactataaa
    12121 accttcgctt gatagaaaag agataacatt aactttgttg cctagaattg ctcgtgctag
    12181 atgtgggtag attcaaaatt tataggcttt attaatcatc atttgattca ccttcatttt
    12241 ggtaggtgtc tccttggtta aaatgataaa aaatgcaaaa agaacttgta ggcatcacta
    12301 caagttcttt tttagataat ataaaaaggt gaaacaaact atctcattac tcgtaacagg
    12361 gaaactatct tacttaaggc ttggtttcat tatataacaa atattaacat gcagcgtttt
    12421 aatgtgtgaa aattacgtga attagcaaac gaaatttcat ctctattcgt taagaattcc
    12481 acttattcgt tttttaacac ctttaaatca acgttgaata gattaacaat atttgctaaa
    12541 ataatattat aataatgcaa tatgcagcaa tttatataat agaaagataa aaaatttaca
    12601 tatcactaat tgaacgctta gccgttgatt aatggagtaa ggtaaataac gaagtacatt
    12661 taatatacaa ttctttccgc agcataagat acgtaattaa gacatttgat agaaatagag
    12721 cgcgaataat gagaaagatg ctgacttgtg ggttacacta atcaacttga aatgttatag
    12781 gggtgtacaa gtactacagc caaaaagtga tctgtaatga atatcgaaga ggcttacgca
    12841 aagttatatg tgagtctatg tgcgaaggaa aaggataacg tttataggag gaagcatgag
    12901 ggggcaactt aatatatgta acgggggaat aatattatga aatttaatac gaaattatta
    12961 aagaaattac ttgtattaag tgcaacgtct gtatcaattt tcagtgcctg ctctgcaaag
    13021 gaagatgggg attacaagcc atataaggaa caagactcta tagaagtcgc aaaggtcgaa
    13081 gaggagaagt ctaatccccc taagattgta gagaagaagt ccactctgcc taaggtcaaa
    13141 gaggatacag aagaacctaa gaagaaaaaa aggctacaac aagtggagga atctaagaat
    13201 aaagatgagg aaattaatga aaaatatccg cattataaag atgtacatga ggacgcatca
    13261 acagtatcac tagaacagta taatcaaatc aaggttggaa tgcctgcgga caaagtcata
    13321 gagatagcag gaaagcctgg atccagcgaa acaactaaat tgttctctat ctatatatat
    13381 ttaggtcacg gtggacacgg ttcgatgact ataaagtttg attctaatag aaatgtaacg
    13441 aacaaagagc aagatggtct tagcaatact gcagttaaag atgagaaggc tagcaaagaa
    13501 catgaagacc ctaatcctga atctgttaag aaatctagtg ctataattcc aaacgatttt
    13561 tgcggacatg gacatgacga aacgaaggag ctagcgcacg actgtgaaaa aattactgat
    13621 aagaaggcat atagaagata tcaactacaa caaaagagag aagagcgaaa aagacaaatt
    13681 aggggcgaag aacaggaatt aattgattac gatcaggggg atgcagctta caaggagcag
    13741 cagcgtatat acgaagaaat acaacgtaga acagaagaaa gggaatcgat tgactacgat
    13801 tacgatcaaa ttagagctgt taacaaagaa aggcagcgta tgtacgaaga aatacaagag
    13861 tgagatgaag aaaaagagtg taaagtgtaa actaaaaaag ctaaatggta cgaggagtat
    13921 atttcataga taggaatttg aattattgaa aaatcaaaat atggaagagt aaataaaaga
    13981 cgctagttgg cgtcttttat ttatcattat tagtaaaact tcactggtga ttactattaa
    14041 tattataata tttgatcttg gaattaactt attagataat gcgtattgat tgtataacat
    14101 ctgacaaatg actaaagata ataaaaaaat tcttgataca aaaatctaaa ttgtataata
    14161 tataggtata ttgttatttg ttgaattccg tttattccca cgccttatgt gttgtggttg
    14221 agttgcagaa gcaagttgtg ttcttgtttc aattttgaaa gggcttcttt gagccgatta
    14281 gtgcatatat agcttatttt gttatgcaca tttttaatcg acttgaagaa gtccttttta
    14341 tgttgttttc aagttgcagg tgggattatt tatgattcat aacaaaatga aataaaataa
    14401 tgtttgaata gtattagttg atctaaaaga gtaatctaaa gagtcggatg atatattgat
    14461 tgatatagat aagttattag ggagtgcaaa tgaagaacta cgatataaat catgtgatgg
    14521 tagtttatac aggggaaaag gaagaactaa gtgatatgaa tacttggagc ttcctttttt
    14581 attgcaatta gaaatctggt agatgattat gcatataaaa atgatttagc ggaaaaattt
    14641 tatttaattt caatacatag aagaaaaagg aaaaaacaaa ttcgtaaagg gctagtttaa
    14701 gtacgattca tttgaataat tgagagggga aatgtattgg tgaaacgtct tgtttcttgc
    14761 tgaccaaggg aatgcaggat gattagtatt actactctca caaaggaaat tacattagaa
    14821 aagggtctgt cagtgtttac aatttatttg ttacatcggt ctaaaagaat ttggatggag
    14881 aagtaaatgc taagtgagaa catgaatgac atttctagaa cttgaacaat tgtgcttttt
    14941 attaatagtg aaaatcagaa gtagaagagg cacaagcgtt aaagtggact gcaaaagtga
    15001 cagaaagaga acaag
//
