LOCUS       NZ_KB976300            23507 bp    DNA     linear   CON 14-JAN-2024
DEFINITION  Bacillus cereus K-5975c achrv-supercont1.1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB976300
VERSION     NZ_KB976300.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus K-5975c
  ORGANISM  Bacillus cereus K-5975c
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5209568)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Bacillus cereus K-5975c
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5209568)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2012) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R38749
            Assembly Name                     :: Baci_cere_K-5975c_V1
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/14/2024 01:11:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,396
            CDSs (total)                      :: 6,275
            Genes (coding)                    :: 5,989
            CDSs (with protein)               :: 5,989
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 5, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 286
            CDSs (without protein)            :: 286
            Pseudo Genes (ambiguous residues) :: 0 of 286
            Pseudo Genes (frameshifted)       :: 113 of 286
            Pseudo Genes (incomplete)         :: 198 of 286
            Pseudo Genes (internal stop)      :: 95 of 286
            Pseudo Genes (multiple problems)  :: 94 of 286
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:03:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4243074
            Orig. end                         :: 4266581
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB976300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Please be aware that the annotation is done automatically with
            little or no manual curation.
FEATURES             Location/Qualifiers
     region          1..23507
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="10"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23507
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23507
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13507](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13507
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(433..442)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            complement(557..1153)
                     /locus_tag="IGY_RS21265"
                     /old_locus_tag="IGY_04263"
     CDS             complement(557..1153)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126039.1"
                     /locus_tag="IGY_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04263"
                     /product="DUF4878 domain-containing protein"
                     /protein_id="WP_001169502.1"
                     /transl_table=11
                     /translation="MQKIKRLLLLMMVVGLTAVVLAGCANPKDTTEEFLTAIQKGDVEK
                     ARTFVESDKEFNKLNEKTDDAEAKAMLSAITKNFKFEKLEEVSKKDDKAEVKVKITSAD
                     LSVAVTKAVGEVMPMAFASAFSEDKEQSEKAIEKTMTSTIIKNLTDKDAAMATREVTLN
                     LKKDKDGDYKIVADDNLKEVLFANAKSLEKMFGGK"
     gene            complement(1295..1563)
                     /locus_tag="IGY_RS35400"
                     /pseudo=""
     CDS             complement(1295..1563)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001195387.1"
                     /locus_tag="IGY_RS35400"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQKETAYLWLLRKTFSFALFCLLSVHFTL"
     gene            complement(1580..1942)
                     /locus_tag="IGY_RS21275"
                     /old_locus_tag="IGY_04264"
     CDS             complement(1580..1942)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036573.1"
                     /locus_tag="IGY_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04264"
                     /product="hypothetical protein"
                     /protein_id="WP_001036577.1"
                     /transl_table=11
                     /translation="MNKKTIFYLLTCILLVASTTYIICNKREQVPPILVWDEQEYYVTN
                     EPAKVEEVGQKLGEVTKKIKTSKNPTKNRESNTLQEKTEVFTMIEEEKSEYPPLIIKEA
                     YSDEYRVVRPMLKQVL"
     gene            complement(2075..2257)
                     /locus_tag="IGY_RS21280"
                     /old_locus_tag="IGY_04265"
     CDS             complement(2075..2257)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="IGY_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04265"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178294.1"
                     /transl_table=11
                     /translation="MQMMYAFGIGLVLFLAVFLFIRKDVQGGTLTKRGFYKLIGCLVVM
                     LIAIIVMIVLINQSL"
     gene            complement(2286..2663)
                     /locus_tag="IGY_RS21285"
                     /old_locus_tag="IGY_04266"
     CDS             complement(2286..2663)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="IGY_RS21285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04266"
                     /product="hypothetical protein"
                     /protein_id="WP_001109904.1"
                     /transl_table=11
                     /translation="MNYSQKYFVIMGIIFLFMSGFMILTGIMTHSAPPAITYPLLGMMI
                     MSFCLSYLHPQFKEKDERMKLIRYKGMFVTFFALTVYYLLFSIGLNLKILTLSATELLN
                     ILMALTMSTVFISFVVLAKRY"
     gene            complement(2666..2875)
                     /locus_tag="IGY_RS21290"
                     /old_locus_tag="IGY_04267"
     CDS             complement(2666..2875)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428510.1"
                     /locus_tag="IGY_RS21290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04267"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428510.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEGEE"
     gene            3699..6566
                     /gene="odhA"
                     /locus_tag="IGY_RS21295"
                     /old_locus_tag="IGY_04268"
     CDS             3699..6566
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="IGY_RS21295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04268"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_016077958.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVGQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMNELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERTWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVLEGAKNGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAV
                     ANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPDQDISKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRMLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEVETITQFTQEQLKSDYA
                     QVPPADTSDATIHVKVPDVVAKGIQPIDTGVEIDSLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGT
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKQEIEVFSN"
     gene            6700..7959
                     /gene="odhB"
                     /locus_tag="IGY_RS21300"
                     /old_locus_tag="IGY_04269"
     CDS             6700..7959
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="IGY_RS21300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04269"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569919.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPPAEQAKQETAEAPKA
                     AAPNAEQTTSLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDNERMENRPMMYIALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     aSDomain        8085..8384
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IGY_RS21305_Heterocycloanthracin_C_RR
                     E.1"
                     /evalue="3.10E-58"
                     /identifier="RREFam011.1"
                     /label="IGY_RS21305"
                     /locus_tag="IGY_RS21305"
                     /protein_end="100"
                     /protein_start="0"
                     /score="184.8"
                     /tool="antismash"
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDW
                     IEKLMPMFNGNHSLAEITDGLPLPYQNRVFEIGEVLYENGFVRDANQDAPHELNS"
     gene            8085..10004
                     /locus_tag="IGY_RS21305"
                     /old_locus_tag="IGY_04270"
     CDS             8085..10004
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="IGY_RS21305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04270"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_016077959.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1230.9,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     5.8e-56, bitscore: 184.8, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 3.4e-11,
                     bitscore: 41.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPIHAKLKVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDW
                     IEKLMPMFNGNHSLAEITDGLPLPYQNRVFEIGEVLYENGFVRDANQDAPHELNSTLLD
                     RYASQIEFLEADSHSGALKFETYRGANVLVLGSGDMLTSLVSSLLESGLPTFHYLVTDR
                     DETNYDRIHELIERAYEVDNGVLIQEIDTTIDRPLHEVFEPFDWILYVSQNGDIDGLKT
                     VHTICRETKKNFIPAICLSTLGIAGPVVTENRDECWESAWHRLHETTLQNENSSDSFSP
                     ITSAMLANVIVFELFKHVADDLYREKKLQFFLLNYETLEGTWHPFIKHPLATDESFTID
                     TIENLSEKLEHRSNQHTSTDVFRFFDSLTSKEAGIFHVWDEQDSYQLPLSQCYIQVANP
                     LSDGPAPLLPLMTRSGLTHNEARREAGLTGIETYVAEIIHRLIPEHNDIGIGAGETMTE
                     GFYRALQQHLNNKLYERQSHMLEELTTIDLTDIHDKHCRFYYDALATIHETPKIAMSEE
                     ILSFPVVWVGINDKWYGASNINMTLALRSALQLSLLHIQSEETPYRANILPESSIILYD
                     TDSFRVEIQAEEEIPSVQSLQLALQHLEEHNFYPFVFDLAIEPFLKENLDGVYGVLIAK
                     EDGL"
     aSDomain        8115..8351
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_IGY_RS21305_Thiopeptide_F_RRE.1"
                     /evalue="1.80E-13"
                     /identifier="RREFam004.1"
                     /label="IGY_RS21305"
                     /locus_tag="IGY_RS21305"
                     /protein_end="89"
                     /protein_start="10"
                     /score="41.3"
                     /tool="antismash"
                     /translation="KVNKDTFFLPDSNGGVYFRNNASSFRMDGDGIYDWIEKLMPMFNG
                     NHSLAEITDGLPLPYQNRVFEIGEVLYENGFVRD"
     gene            10001..11950
                     /locus_tag="IGY_RS21310"
                     /old_locus_tag="IGY_04271"
     CDS             10001..11950
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="IGY_RS21310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04271"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_016077960.1"
                     /sec_met_domain="YcaO (E-value: 4.1e-83, bitscore: 278.1,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 9.3e-142, bitscore:
                     470.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQNILLIGDGLLADYVHDQLCKQYSIIRQHTLTEELPENIYLAL
                     VLHDGSPSTIHHDAELIFRSNHIPWLRGFTSFGEGIIGPYIHPLTPGCSHCSDGRRFIA
                     GFDQKEMWELQRKYAFKAENGTRRDVRATQNGMLQMCHLICAETEKILTHNHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPVCSSLPDDTADAAEVSLQPSLKVSTETYRCRSIHELN
                     TFLTKDYLDYRIGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFAVSEATAILE
                     GLERYCGMSPRGKKTNVHGSFHDLEEHALNPLTLGVHTNEHYNRDNFPFKPFDPDYEQN
                     WVWGYSLSQNRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLRTITGYELHAFNATMEHGIPSLWVIAK
                     NTRENGMNVVCAGGAHLDSIRALKSAIQEIAGMLLITDDELEHKREYYEKCLQDPYFVN
                     KMEDHSMLYGLKETEERLHFLLREDAPVQTFQEMNVSQSFDMDLTSDLRQLLNRLHQSN
                     LEIIVVDQTAPLIEKNGLHCVKVIIPGMLPMTFGHHLTRITGLDRVYTVPMTLGYTDEP
                     LTNERLNPHPHPFP"
     gene            11966..13507
                     /locus_tag="IGY_RS21315"
                     /old_locus_tag="IGY_04272"
     CDS             11966..13507
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716912.1"
                     /locus_tag="IGY_RS21315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04272"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_016077961.1"
                     /sec_met_domain="PF00881 (E-value: 5.9e-09, bitscore: 34.5,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFSIDEIMPNHEVDWKDAPLPYKLYRNVPTIPLSL
                     EIPLSLPNSSTTPTLDEIGHYLWYSFGVTQLCQLNSERNVLRRSIPSGGALYPNELYIY
                     LKIDDYPDGIYHYDAAHHRLILLREGNFDSYLADALGNRCNIQSCFGAAFISTMFWKNF
                     FKYNNFSYRLQGLDSGVLIGQLLESAKQFGYTNGVYFQFLDRAMNHLVGLSEGEESVYA
                     VIPLSTEPETNWFHNDYRENKTVTSHELLQQIPPLAHEHFVRSKHVGEYPMITKINEAS
                     MIESTAHFQTLHHEEHYQHNAYAVQLPKVERLSYDFLQLCKKRYSPDADFILTKWDAAE
                     LATLLQEASLSFPYYNDLDGKYANENARVFLYGCFYNVKNIENGAYAYNSKTHSIQPIR
                     YGDLRYPLQSSMTMDNVNLFQVPLCLHVVGKKDYYTRALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFDTNSCDQLYGIDAGNETSLIQIPVGAYRARNWLKGVLHS"
     gene            complement(13538..13948)
                     /locus_tag="IGY_RS21320"
                     /old_locus_tag="IGY_04273"
     CDS             complement(13538..13948)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="IGY_RS21320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04273"
                     /product="DUF3908 family protein"
                     /protein_id="WP_000996785.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIAESNARHEEDFGNVVEEMKEVCIGLDNATLIYT
                     KNVFCFGKKVEVFFFFQDHVVIGQEKDECIEIEKLKYDAITHSNLKTNDKNTMLELKFA
                     NGQSINLDSLNDNYGTKNWLFARQIKSIFKLI"
     misc_feature    complement(14023..14038)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.05"
                     /tool="antismash"
     gene            complement(14095..14583)
                     /locus_tag="IGY_RS21325"
                     /old_locus_tag="IGY_04274"
     CDS             complement(14095..14583)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000498239.1"
                     /locus_tag="IGY_RS21325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04274"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_016077962.1"
                     /transl_table=11
                     /translation="MFVTLQIVQESEKEILRNLYALYLHDLSTFTPNITIEANGFFEYE
                     DLHMFWENDGITPYFIKSDNDIVGFLLLLERPFLKKENDFGINDIFILNQYKGKGIGKQ
                     VIANVLKEKRGQYFVIELVKNIPAVSFWKKVYGEINIEFDEKTQLIDDEECLVQTFEI"
     gene            complement(14685..16019)
                     /locus_tag="IGY_RS21330"
                     /old_locus_tag="IGY_04275"
     CDS             complement(14685..16019)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="IGY_RS21330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04275"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_016077963.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-63, bitscore:
                     213.1, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDENATVVTLEKGEIYSYAQCGLP
                     YVISGAIASTEKLIARNVKTFRDKYGIDAKVRHEVTKVDTEKKVVYAEHTKTKDIFEFP
                     YDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHHIEILTNENVKAFKGKER
                     VEAVETDKGTYKADLVLVSVGVKPNTDFLEGTNIRKNHKGAIEVNAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPLGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAKPLYLKILYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            16217..16648
                     /locus_tag="IGY_RS21335"
                     /old_locus_tag="IGY_04276"
     CDS             16217..16648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000332402.1"
                     /locus_tag="IGY_RS21335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04276"
                     /product="hypothetical protein"
                     /protein_id="WP_000332402.1"
                     /transl_table=11
                     /translation="MCAGLLAQLPDEPQEPKEPKPALSLDQEFSINATIYSARAWLSND
                     DTFAQDIWKATQFASASHAGKSIFPVGSVKILNFSDDTITVTASPESDHALKIVVPPHS
                     EAALTSGPLSHIQASTSGGSSKVTFLFHIFFSRDPGSDK"
     gene            complement(16692..17927)
                     /locus_tag="IGY_RS21340"
                     /old_locus_tag="IGY_04277"
     CDS             complement(16692..17927)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017672808.1"
                     /locus_tag="IGY_RS21340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04277"
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_016077964.1"
                     /transl_table=11
                     /translation="MNVCTKCGIQFEDGVQFCQNCGTKRGSPVVKKNMSGGAKVGITLL
                     ALFVIAIIGLYLYGSSYYTQVAQVDRMITILQERDGEKLAEIITADDQSVMITKESLTP
                     LFSYIKENPSYVNELKEYLRQGEKQRDGIERADFSLTKDGKYFFIFDRYKLKVKTYYTT
                     LLTNEKGVSLKMNGKEIDKTDDKKFEKQYGPFLPGNQVFQSEYKNDYVKLSREEKVVLM
                     KQSQNNVMIDLTLQGQYITVQTNAPGATLYVNQKPVTALAGGEITWGPIATDGSTTIYL
                     ERNGENGRETTKVETVTALPSYNLPFQKKSTEKTVVYNVTPPSTNPYVYNGFIFPDSDI
                     RKLTSTDLAYLSKEQLKIARNEIYARHGHIFQTKDMQTYFSKQSWYRENPYFTGKLTDI
                     ETYNVELIKSRE"
     gene            complement(17947..18732)
                     /locus_tag="IGY_RS21345"
                     /old_locus_tag="IGY_04278"
     CDS             complement(17947..18732)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650096.1"
                     /locus_tag="IGY_RS21345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04278"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_000650096.1"
                     /transl_table=11
                     /translation="MKCPSCHTENAAEAKFCGNCGHSLTEEVVASSGQEEGPEQARAAQ
                     VKETRPNETVEQAKRFASGYFQFFKHALQAPTAIMKSGTIEVRNGIVSLVLICFLGACI
                     FYRMMSAASAVTRTFAPDISTPTFFVESITVFFFLLILTLFVGFIIFVSGKMMKSSFSF
                     LEVFGIWGTLATPAIAILVLSFLFSFLLIFFLPILLSVAATYIGISITVAILKLDNGGL
                     DLVYTLIIANVLIGIATFIVLWSYISTIIQALTQGITGF"
     gene            18929..19762
                     /locus_tag="IGY_RS21350"
                     /old_locus_tag="IGY_04279"
     CDS             18929..19762
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017762920.1"
                     /locus_tag="IGY_RS21350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04279"
                     /product="hypothetical protein"
                     /protein_id="WP_016077965.1"
                     /transl_table=11
                     /translation="MELVNSIFQILLTSVIQLFSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYVQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPESYFLFNTTLEKTIASTSINVEMIQNML
                     LSTFVLLKSLFTIGNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVIVMFIVLFLF
                     NIIAGLFQYDSNQLIGQVMKYNMYLIAFSSVALLFSCLSTLVSFSFYKIRRGCSF"
     gene            complement(19777..20460)
                     /locus_tag="IGY_RS21355"
                     /old_locus_tag="IGY_04280"
     CDS             complement(19777..20460)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128607.1"
                     /locus_tag="IGY_RS21355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04280"
                     /product="YukJ family protein"
                     /protein_id="WP_001128581.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKIGKGKTPHYQVHLQDEVGVDYRIAINVK
                     SQSYPSEVLYFASNNIKSEAIHILPTLPFGFTEIKNNEPKVALDYVRGNLFDSKQMIPL
                     PPEKAGADNDLNEKIERYIKRAIEEKAIIYAFGERWGPEENTPDSYFHFKPGNGIHDIH
                     MNQGNVEKWKGDNGIWQDGGILIHFEKEEEWIGIFLAFQSQSWCTDEEGHARVPVEHCD
                     YKGNN"
     gene            complement(20551..22050)
                     /locus_tag="IGY_RS21360"
                     /old_locus_tag="IGY_04281"
     CDS             complement(20551..22050)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015129 - lactate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015727 - lactate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126004.1"
                     /locus_tag="IGY_RS21360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04281"
                     /product="L-lactate permease"
                     /protein_id="WP_016077966.1"
                     /transl_table=11
                     /translation="MAILLALIPIMMIFICLFLFKQTSLRSSLISYAVSVGIVLLSPMF
                     QLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEEVTQDRLLQM
                     LLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTI
                     IGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGVGFFLLFSLG
                     IYLSNAYVSVELAGILSSIVTITFGFLIIKLKGKSGQNLITEHAAATEREVSIIKIISP
                     YIFLTVCILLSRLVPALHDLFRSYAVLDLKSYSYKLELLYSPGFWLGMTCLFTIIFFRI
                     PSNIIKQSFSQTIKQWIPFAITTTMFIAISELMGASGMHSLLAKTAGETFGTFFVFVAP
                     FIGAIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITL
                     GAYLCNIPYRENELLKKTTLMIFGAVLLVVVEVIVWYMLRN"
     misc_feature    22006..22021
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.85"
                     /tool="antismash"
     misc_feature    complement(22142..22156)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.76"
                     /tool="antismash"
     misc_feature    22143..22157
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.41"
                     /tool="antismash"
     gene            complement(22165..22524)
                     /locus_tag="IGY_RS21365"
                     /old_locus_tag="IGY_04282"
     CDS             complement(22165..22524)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016082428.1"
                     /locus_tag="IGY_RS21365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04282"
                     /product="DUF4029 domain-containing protein"
                     /protein_id="WP_000946136.1"
                     /transl_table=11
                     /translation="MLRRKLLYLLLTIPLYAWLISMTKIELMALFLGYVFIFSNLNRIQ
                     EQSILEICLFSISIELFSIVSIVLLNELFLRIHSFTLMKFWNIALQAICTYIVFVVLKK
                     IIGQQTVFQDNRKWE"
     misc_feature    22553..22571
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.43"
                     /tool="antismash"
     gene            complement(22598..23374)
                     /gene="trpA"
                     /locus_tag="IGY_RS21370"
                     /old_locus_tag="IGY_04283"
     CDS             complement(22598..23374)
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016133917.1"
                     /locus_tag="IGY_RS21370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_04283"
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="WP_016077967.1"
                     /transl_table=11
                     /translation="MGVEKIKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASI
                     VEIGIPFSDPVADGPTIQRAGKRALDSGITVKGIFQALIEVREEVQIPFVLMTYLNPVL
                     AFGKERFIENCIEAGVDGIIIPDLPYEEQNIITPLLREANIALIPLVTVTSPIERIEKI
                     TSESEGFVYAVTVAGVTGVRQNFKEEIRSYLEKVKSHVNLPVVAGFGISTKEHVEEMVT
                     ICDGVVVGSKIIELLENEKREEICELIYATKQKEEA"
ORIGIN
        1 taagatttta aatatttaat atgcaattct gcatatttta atagtctcaa ttatttacat
       61 agtgtttgac catctttatt taaagcagcc cccacattta caaaattcac ttaaaacaag
      121 aatttgttta tccatacttt ttctataatt tttcatggaa gaactgaaat taattagtac
      181 ccctgttaaa cacctaaatc tgatacttaa actaactaat cttcctctaa taaattgttg
      241 tcttatttaa cttcacaatt aatagtatcc agcaggcata gtcacaacat cttcgtacac
      301 ctcctcatta aagctgaagg aacactaatt aaaatctggt ccagaaattt tacctttcta
      361 cgttacagga tccgcataag aaaacataga atacagtacc tcctctgtta caactagctt
      421 tatgtcttga attcaaaaaa cataatatct aatttatata attattttcg tgagttcaaa
      481 cctctccagg ttcataaaaa agagacacca tatcaacctt ctacgtgata tggtgtctct
      541 tttttatcta attcaattac ttcccaccaa acatcttctc caaagacttt gcattggcaa
      601 acaatacttc tttcaagtta tcgtcagcaa cgattttata gtcgccatct ttgtctttct
      661 ttaagttcaa tgtaacttcg cgagttgcca ttgctgcatc tttatccgtt aagtttttga
      721 tgatagttga ggtcattgtt ttttcaatcg ctttttcaga ttgttctttg tcttcgctaa
      781 atgcgctagc gaaggccatt ggcataactt ctcccactgc ttttgttaca gcaacggata
      841 gatcagcaga tgtaattttc actttcactt ctgctttgtc atcctttttc gatacttctt
      901 ctagcttttc aaatttaaag ttctttgtaa ttgcacttag cattgctttt gcctcagcat
      961 catctgtttt ttcatttagt ttattaaatt ccttgtcact ctcaacaaat gtacgagcct
     1021 tttctacatc acctttttgt atcgctgtta aaaattcttc tgtagtatct ttcggatttg
     1081 cacaccctgc taaaacaacc gctgttaatc ctactaccat cattaatagc aataatctct
     1141 ttatcttttg cacgctcatt ctcctcatta tcttttctag taagtcagta tcatacaata
     1201 ttatgaaact gacattacaa acatttttta gtatagcatt tatatgatta attttctatt
     1261 aattcccaaa aatataaaga gccttgcagc attcctacaa ggcctctctt ctatcaatct
     1321 gtatccgtag cacaaatgaa ccacattttc tgttccctac taccatccat atagtccgat
     1381 caaagatcat aagcgataac caaagtgata tattaatagc agcaaataat aaatataaaa
     1441 tgaagtctct cttttgtagt gcccctctat tcattacaat gtaaaatgca ccgataggag
     1501 gcaaaataaa gcaaaggaaa aagtttttct taacaaccat agatacgcag tttctttctg
     1561 catatgaatc cccttttcat cataatactt gcttcaacat cggcctcact accctatatt
     1621 catcactata agcttccttt atgattaaag gcggatattc acttttttct tcctcaatca
     1681 ttgtaaacac ttctgttttc tcttgtaatg tattagattc tctattttta gtagggtttt
     1741 tacttgtttt aattttcttt gttacttcgc caagtttttg cccaacttct tctactttgg
     1801 caggttcatt cgtaacatag tattcttgtt cgtcccatac taatataggt ggcacttgtt
     1861 ctcttttgtt acatattata taagtagtac tagctacaag tagtatacaa gttaataaat
     1921 agaagatagt ttttttattc atatactaca ctccttatct atcagttcat tggattatat
     1981 aacacaattt atttacagta aatggattta gcggtaattt ttaggtttaa taataaagaa
     2041 aaaccttacc gaagtaaagt tccgttttta cattctatag tgactgatta attaatacga
     2101 tcattacaat aatcgctata agcataacaa ctaaacagcc gattaattta taaaatcctc
     2161 gcttcgttaa tgtcccacct tgaacatctt tacgaataaa taagaatacg gctaaaaata
     2221 atacaagccc aatgccaaaa gcatacatca tttgcatatg ttaatcttcc tttctctctt
     2281 ccatcttaat atctttttgc caaaacaaca aatgagataa agacggtact catcgtaagt
     2341 gccataagta tattcaataa ttcagtagca gatagtgtaa gtatttttaa gtttaagcca
     2401 atagagaaaa gaagataata tactgttaat gcaaaaaagg ttacaaacat tcctttataa
     2461 cgaatgagtt tcattcgctc atctttttct ttaaattgtg ggtgtaagta gcttaggcag
     2521 aaactcataa tcatcatccc aagcaatgga tacgttatag ccggcggtgc agaatgcgtc
     2581 attatacctg ttaatatcat aaatccactc ataaatagaa agataattcc catgattaca
     2641 aagtactttt gtgaatagtt cattcttact cctccccttc ttttccttca taaataaata
     2701 catgttctat cgttgtctga aatgtttttg ctatttcaaa tgctagcgga agtgatggat
     2761 cgtatttccc tttttcaatt gagataatgg tttgtctgga aaccccgagt ttctcggcca
     2821 gtttttcttg agatagtcca aatttctttc ggtattcgac cattttattt tccaaggaaa
     2881 tttctccctc cttccatata tcgagtatat atgtaaagta aactttacgt caaggttcct
     2941 ttacatttat ttcaatcagt tttcgttcta tttatataga agaaacttgt tcgatttcag
     3001 cacgtctatt ttgtaataaa acatggaaca ctgtatgtaa tcgttactat atttcctcct
     3061 cactttttta aaaatttaat atcttcatat ttgttttatc cttttaaaat atttcattct
     3121 ctgctttatt agatgcaatg tgttatttgt tttacggtgt tttttggcat atttatagaa
     3181 actaacgggt tataaagcat tttttatgtt taaccacttt ttttgtagaa atccttcatt
     3241 ttcctttcga tatttaacac tatcgaaata aagtttatgg taaattcata attttttatt
     3301 ttttatacta tattccgtta tattgttgta taatatctat gaaagcgctt attatttcaa
     3361 tatacataat tcgaatcaac ttttatcaaa acattccaat gattatactt atatttacat
     3421 gtaacaattc tagttttcaa tgtaggtata ccaaatatat ccaccccatt tttctgtaaa
     3481 attactttat aaagtgaaag attaacttgg gtgataagtt attgtgaatg tttttttaca
     3541 aaacagataa gtaatagtgt ttggtattat gtaaattatt gtaataacat aagagtaaag
     3601 aaaacattta cattgattat tggttcatca attattgaaa agagcaaaat gcaccttttg
     3661 tatggaaaag gattatatgc atcgggaggt ttaaacaaat gacgaggaag aatacaacga
     3721 caaacccttg ggccaagttc cacggtccga accttggtta tgtgattgaa cagtatgatc
     3781 tttacgtaac tggagcaggt tctgttgatc cggaattaca agagcttttt gaaatttttg
     3841 gagctccttc gtttcaagat gatgtcgtaa caggggacaa cacagcaaca catttttctc
     3901 ctcaaaacac aggtaacatt gaaaaaattc ttaaagtcgt tcaacttgtt gggcagattc
     3961 gttctttcgg gcacacgttg gctcacatca acccgatgga agatgctgca aatggacaat
     4021 ctcttcttga gaaagcaatg aacgaactga gcgatgctga cttgaaagcg attccagcga
     4081 aaacagtatg gcaagatgca ccagaaggta ttcacactgc acttgatgta attcatagat
     4141 taaaagacgt ttatacaaaa tctttagctt atgaattttc tcatatacaa gatagtgaag
     4201 aacgcacgtg gttgcatcaa atggtggaat caaattcatt gcgtcaacca ctatcaaata
     4261 aaaaacgaac tgctctttta aaacgtttaa cagctgttga aggtttcgag caattcttgc
     4321 ataaaacatt cgttgggcaa aaacgtttct ctatcgaggg cgttgatatg cttgtgcctg
     4381 ttttagatga aattgttcta gaaggtgcta agaacggtgt agaggatgtc atgattggta
     4441 tggctcaccg cggtcgtcta agcgtacttg ctcacgtatt agaaaaacca tatagtcaca
     4501 tgtttgctga gttcaaacat gcaaaaatag aaggcgcagt agccaattct ggctggactg
     4561 gcgacgtaaa ataccaccta ggtagagaac aagtcgttag taacgaagaa gttagcactc
     4621 gcgtgacatt agcaaataac ccgagtcatc ttgagttcgt gaatcctgta gtagaaggtt
     4681 tcgcacgtgc tgctcaagag aatcgtaaaa aatctggtct tccagatcaa gatatttcaa
     4741 aatcattcgt aattttagtt catggtgatg ctgcattccc tggtcaaggt attgtatctg
     4801 aaacgctcaa cttaagcaga ttgaacgcgt atcaaacagg cggaacgatt catgttatcg
     4861 caaacaatgc agttggtttt acaactgata gctatgattc tcgttctacg aaatattcaa
     4921 gtgaccttgc aaaaggtttc gatattccga ttgttcacgt gaacgctgat gatccagaag
     4981 cttgtcttgc agctgctaac cttgcgattc aatatcgcat gttgttcaaa aaagacttct
     5041 taatcgattt aatcggttac cgtcgatatg gtcataacga aatggatgac ccagcggtta
     5101 cgcaaccaca agtgtacaaa aaaattaaaa atcacccaac tgtaagagca atttatgcag
     5161 atcaattaca agctgctggt gttctaaatg cagatgaggt tgaaacaatt actcagttta
     5221 cgcaagaaca attaaaatcc gattatgcac aagtaccgcc agctgatacg agcgatgcaa
     5281 caattcacgt taaagtgcca gatgttgttg caaaaggcat tcaaccaatt gatactggtg
     5341 ttgagattga ctcacttcgt gcaattaatg aaggtctact atcttggcca gaaggcttta
     5401 acgtatatcc gaaagtgaag aaaattcttg agcgccgtaa agatgcttta gaagagaacg
     5461 gtaaaattga atgggcactt gctgagtcat tagcattcgc ttctatttta caagaaggta
     5521 cgccaattcg tttaactggt caagattcac agcgtggtac atttgcgcac cgtcatatcg
     5581 tattacacga tactgataca aatgaaacat attcaccatt acatcgctta ccaaacatta
     5641 atgcatcatt ctctgttcat aacagtccgt tatcagaggc tgctgttgtt ggttacgaat
     5701 atggttataa cgtattcgct ccagaaactc ttgttatgtg ggaagcgcaa tatggtgact
     5761 tttcaaatac tgcgcaagca ttatttgatc aatatgtttc agctggaaga gcaaaatggg
     5821 gtcaaaaatc tggtttagtt cttctattac cacacggtta tgaaggtcaa ggaccagagc
     5881 actctagtgc acgtccagag cgtttcttac agttagctgc tgagaataac tggacagttg
     5941 caaacttaac gagcgcggca cagtacttcc atatcctgcg tcgtcaagca tctatcttag
     6001 gaacagaagc tgttcgacca ttagtactga tgacgccgaa gagtttatta cgtcacccac
     6061 ttacgctttc aactgctagt cagttaagcg aaggacgttt ccaacctgct ttagaacaag
     6121 aaaaccttgg cacgaaacca aataaagtaa aacgtcttgt tttaagcaca ggtaaaatgg
     6181 cgattgactt agcagcagaa atcgagtctg gtaaacatga gtacaactta gacgaagttc
     6241 atgtcgttcg tatcgagcaa ttgtacccat tccctgctga gaaagttcaa tctattatta
     6301 aacgatttaa aaacttagaa gaaatcattt gggttcaaga agaacctcgt aatatgggcg
     6361 catggcatta catggctcca attctgttcg aacttgctgg agataaagtg aaaacaggtt
     6421 acattggacg tcctgatcgc tctagtccat ctggcggcga tccattcgct cacaaagctg
     6481 agcaagaact aattgttgca cacgctttag atgtgaagta taacttccgt caagataaac
     6541 aagaaattga agttttcagc aactaaaaag taataatgaa ggtttctagc ttgttccctg
     6601 ggcagatatt ctgcccaagg ccaggctaac aaatggagat taccgaagac aaaagaagaa
     6661 aaaacacacc gttaggcaaa taaggggagg acatttaaaa tgatcgaaat taaagtacct
     6721 gagcttgcag aatctattac cgaaggaact atttcacaat ggcttatcaa cgtaggcgac
     6781 aaagttgaga aaggcggcag cgttgttgag cttgaaactg ataaagtcaa tgtagaaatc
     6841 attgcagaag attcaggtat tgtatcgaag ttactaggcg aacctgggga tacagttgaa
     6901 gttggcgcaa ctatcgcaat tttagatgct aatggagcac cagttgcagt aagtacacct
     6961 gcaccacctg ctgagcaagc aaaacaagaa acagctgaag caccgaaagc tgcggctcca
     7021 aatgctgaac aaactacgag tctacaaggc ttaccaaata cgaaccgtcc tatcgcatca
     7081 ccagctgcta gaaaaatggc tcgtgaatta ggaatcgact taaacgacgt acgtagtaca
     7141 gatccacttg gacgcgtgag accacatgat gtacaagctc atgctgccgc accaaaagaa
     7201 gcaccagctg ctccaaaaag tccagctcct gctccagttg caaaaacaga attcgaaaaa
     7261 ccagttgagc gcgtgaaaat gtcccgccgc cgtcaaacaa ttgcaaaacg ccttgtagaa
     7321 gttcaacaaa catctgcaat gttaacaaca tttaacgaag ttgatatgag tgcgatcatg
     7381 gaattacgta aagagcgtaa agacgctttc gagaaaaaac atgatgtacg tcttggcttc
     7441 atgtcattct tcacaaaagc agttgttgca gcattaaaac aattcccatt attaaatgct
     7501 gaaattcaag gtgacgagct tatcatcaaa aaattctatg atatcggtat tgcagtagca
     7561 gctccagatg gattagttgt tccagttgta cgcgatgcta accaattaaa cttcgctgaa
     7621 atcgaaagtg aaattcgtaa tttaggtatg aaagcacgcg ataacaaact ttcattaaaa
     7681 gaactacaag gtggtacatt tacaattaca aacggtggtg tattcggttc tctaatgtca
     7741 acaccaatcc taaatagccc tcaagttggt attttaggaa tgcataaaat ccaagtacgc
     7801 ccagttgcaa ttgataacga gcgtatggaa aaccgcccaa tgatgtacat tgctttatct
     7861 tacgatcacc gtattgttga tggtaaagaa gcagttagct tccttgttgc tgttaaagat
     7921 atgcttgaag atccaaaatc attattatta gaaggttgat agattaataa tctaatatat
     7981 aaaggctgta gaatacatca ttctacagcc tttttttgcg ttcatacggg acaaatttca
     8041 tgacataaga taataatgta tgcctaaacg taaggaggat taaaatgaat aaccttccaa
     8101 ttcatgcaaa acttaaagta aataaggata ctttcttcct gcccgattca aacgggggtg
     8161 tctattttcg aaataacgcc agttcatttc gcatggacgg tgatggaatt tatgactgga
     8221 ttgaaaaatt aatgccaatg tttaacggta atcattcttt agcagaaata actgatggtc
     8281 tccctctccc ctatcaaaat cgtgtatttg aaattggaga ggttttatat gaaaatggtt
     8341 tcgttcgcga tgcaaatcaa gatgcacctc atgaattaaa cagtacatta ctcgacagat
     8401 atgcttcaca aattgaattt ttagaagctg attctcattc aggtgcttta aaatttgaaa
     8461 cgtaccgcgg agcaaatgtc cttgtacttg gctccggaga tatgcttact tctttagttt
     8521 cttctttatt agaatctggt ttacctacat ttcattacct cgttacagat cgagatgaaa
     8581 caaactatga cagaatacat gagctaatag aacgtgcata tgaagttgat aacggtgtac
     8641 tcattcaaga aatcgatact acaattgacc gtcccttgca tgaagtattc gaaccttttg
     8701 attggatttt atatgtttct caaaatggag acattgacgg tttaaaaaca gttcacacta
     8761 tttgtagaga aacgaaaaag aattttatac cagctatttg tttatcaaca ctcggtatag
     8821 ctggacctgt cgtaacggaa aatcgtgatg aatgctggga atccgcatgg catcggctac
     8881 atgaaacgac tttgcaaaat gaaaattcat cagattcctt ctcaccaatt acatctgcaa
     8941 tgttagcaaa tgtaatcgtt tttgaattgt ttaaacatgt cgcggatgat ttatatcgtg
     9001 aaaaaaaatt acaattcttt ttattaaact atgaaacact tgaaggaacg tggcatcctt
     9061 ttataaaaca ccctcttgca actgatgaaa gttttacaat tgatacgata gaaaatcttt
     9121 ctgaaaaact tgagcatcgg tccaaccaac atacttcaac tgatgtattc cgctttttcg
     9181 actcattaac ttctaaagaa gccggtatat tccatgtatg ggatgaacaa gattcatatc
     9241 aattaccgtt atcacaatgc tatattcaag tagccaatcc attatcagat ggcccagctc
     9301 cccttctgcc tcttatgact cgcagtggat taactcataa tgaagcacgc cgagaagctg
     9361 gtttaacagg aattgaaaca tatgtagcag aaatcattca ccgccttatt cctgaacata
     9421 acgatatcgg tattggcgct ggagaaacga tgacagaagg attttaccgg gcactacaac
     9481 aacatttaaa taataaattg tatgaacggc agtcacatat gctagaagaa cttacaacga
     9541 ttgatttaac tgatattcac gataaacatt gtagatttta ttacgatgcc cttgctacaa
     9601 ttcatgaaac acctaaaatc gcaatgagtg aagagattct cagttttcca gtcgtttggg
     9661 ttggtataaa tgataaatgg tacggtgcat ctaatattaa tatgacgtta gcgttacgga
     9721 gcgcactaca actatcactg ctccacattc aaagtgaaga gactccttac agagctaata
     9781 tcttgcctga atcatctatt attttatatg acacggattc ttttagggtg gaaatacaag
     9841 cggaagaaga aattccaagt gtgcaatctt tacagcttgc cttacagcat ttagaagaac
     9901 ataattttta tcccttcgtg tttgatttag caatcgaacc atttttgaaa gaaaacttag
     9961 acggtgtgta tggggtatta attgcaaagg aggacggtct atgactcaaa atatattgct
    10021 tataggggat ggccttcttg cagactatgt acatgatcaa ttatgcaaac aatattccat
    10081 cattcgtcag cataccctta cagaagaact tcctgaaaat atttatctcg ctctcgtatt
    10141 acatgatgga tctccttcta ctattcatca tgatgctgag ctaatttttc gctcaaatca
    10201 tattccgtgg cttcgtggtt tcacttcatt tggcgaaggt attatcggtc cttacattca
    10261 tcctcttacg cccggatgtt cccattgttc tgatggacgc cgttttatcg ctggctttga
    10321 tcaaaaagaa atgtgggaac tacagcggaa atatgccttt aaagccgaaa atggaacgag
    10381 gcgtgatgta cgtgccaccc aaaatggcat gttacaaatg tgccatctta tttgcgcaga
    10441 aacagaaaaa atattaactc ataaccattc ttctttagaa aatgaactta ttttactaaa
    10501 cttacaaaca ttacaatgta cgcggcattc ttttcttcca gatcctctct gtcctgtatg
    10561 tagtagttta cctgatgata ctgcggatgc ggcggaagtt tctttacaac cgagtttaaa
    10621 agtaagcacc gaaacgtatc gctgccgttc cattcatgaa ttaaacacat ttttaacgaa
    10681 agactattta gattatcgga tcggtatgtt gaacggcaaa atgcagcatt ctttattgcc
    10741 attcgctgac gtcattataa acatgccatt aatgtttgga aatgaaggtg ttgcaggccg
    10801 aactcattca tttgcagtga gtgaagcaac tgctatttta gaaggtttag aacgatattg
    10861 cggtatgtcg cctcgcggga aaaagacaaa tgtgcatggt agttttcatg atttagagga
    10921 acatgcacta aatcccctta cactcggtgt gcatacaaat gaacactaca atcgtgataa
    10981 ttttccattt aagccgtttg atcctgatta tgagcaaaac tgggtatggg gatattcttt
    11041 atcacaaaac agaccgcttt tagttcctga atcaattgct tattatagcc ttggtcatcg
    11101 agatgctttc gtgtatgaaa catcaaatgg atgtgcaatt ggcggtagtt tagaagaagc
    11161 gatttttcac ggcattttag aaattgtaga gcgtgatgcc ttcttactca cttggtatgc
    11221 cgaattacct cttccccgcc ttgatcttag ttcagcaaat gatacagaat tacaattaat
    11281 gatccagcgg ttacgtacga ttactggata tgaattacac gcttttaacg cgacgatgga
    11341 acacggcatc ccgagcttat gggtaattgc aaagaataca cgtgaaaatg gaatgaacgt
    11401 tgtttgtgcg ggaggcgctc atttagattc tattcgagct ttaaaaagtg ccattcaaga
    11461 aatagcaggc atgttactta taacagacga tgagctcgag cacaaaagag aatactacga
    11521 aaaatgctta caagatcctt atttcgttaa taaaatggaa gaccatagta tgctgtacgg
    11581 attgaaagaa acggaagaac gtcttcactt ccttttacga gaagatgcac cggtgcaaac
    11641 gttccaagaa atgaatgtat cacaatcatt tgatatggat ttaacatccg atctccgcca
    11701 acttttaaat cgtttgcatc aatctaatct tgaaataatc gttgtagatc aaaccgctcc
    11761 ccttatagaa aagaacggac tacactgtgt aaaagttatt attccaggca tgttaccgat
    11821 gactttcgga caccatctta ctcggattac aggactggac cgggtatata ccgtaccgat
    11881 gacacttgga tatacagacg aacctttaac gaatgaaaga ttaaatccac atccacatcc
    11941 gtttccatag taaaggaggg atttcatgca gctagatact tttttacatc atctccattt
    12001 ctctatcgat gaaattatgc cgaatcatga ggtggactgg aaagacgcac cgcttcctta
    12061 taaattatat cgaaatgtac ctaccatccc gctctcctta gaaatcccat tatctttacc
    12121 gaactcttct actacaccta ctttagatga aattggtcac tacctttggt attcatttgg
    12181 tgtaacacaa ttatgtcagc taaatagcga gagaaatgta ttacgaagat ctattccttc
    12241 aggcggcgct ttatatccga atgaattgta tatctattta aagattgacg attatccaga
    12301 cggcatttac cattatgacg ccgcgcatca ccggcttatt ttacttcgcg aaggaaattt
    12361 cgattcttat ttagcagacg cactcggtaa tcgctgtaac atacagtctt gtttcggtgc
    12421 tgcatttata tctactatgt tttggaaaaa tttctttaaa tacaataatt tttcatatcg
    12481 tcttcaagga ttagatagcg gggtccttat tggacaatta ctagaaagtg caaaacagtt
    12541 tggctacaca aatggcgtat attttcaatt tctagaccgg gcaatgaatc acttagtcgg
    12601 attgtcagaa ggtgaagaaa gtgtgtatgc cgttattcct ttaagtacag agccagaaac
    12661 taattggttt cacaatgatt accgtgaaaa taaaacagtt acttctcatg agttgttgca
    12721 acaaattccg ccgttagcac atgaacattt cgttcgctca aaacatgtag gtgaatatcc
    12781 gatgataaca aaaataaatg aagcttctat gatcgaatcg acagcacact tccaaacact
    12841 acatcatgaa gagcactatc aacataatgc gtacgctgta cagctaccaa aagtagaacg
    12901 gttatcgtat gatttcctac aactttgtaa aaaacgatat tctcctgatg cggactttat
    12961 tttaacgaaa tgggatgcag ccgagctcgc tactttacta caagaagcga gcctctcctt
    13021 cccctattac aacgaccttg acggtaagta tgcaaatgaa aatgcacgcg tcttcttata
    13081 tggatgtttt tataacgtga aaaatattga aaacggggct tacgcttata atagtaaaac
    13141 acattcgata caaccaattc ggtatggaga ccttcgttac cctcttcaat ctagtatgac
    13201 gatggataac gttaaccttt ttcaagtacc actttgctta catgtagtcg gaaagaaaga
    13261 ttactataca cgtgcattag gctatagagg atatcgtatt caccaaatgg aagctggtat
    13321 cctcgttcat aaactcgttt ttgcagcgac cgcgatgggg atgggcgggc atccattact
    13381 tagttttgat acaaattcat gtgatcaatt gtacggtatt gatgctggga atgaaacgtc
    13441 tcttattcaa attcctgttg gggcgtatcg agcgcggaat tggttaaaag gggttttgca
    13501 tagttaaaag cacgccgatg gacggcgtgc ttttttacta gattaactta aaaatactct
    13561 taatttgtct agcaaataac caatttttcg taccgtagtt atcatttaaa ctatctaaat
    13621 tgatagattg tccgttagca aactttaatt ctagcattgt atttttatca tttgttttta
    13681 agttactatg tgtaatagca tcatacttta atttttcaat ctcaatacat tcgtcttttt
    13741 cttgtccaat cacgacatgg tcttggaaga agaaaaagac ttctactttt ttaccgaaac
    13801 aaaatacatt tttcgtatag attaatgtcg cgttatcaag tccgatgcat acttctttca
    13861 tctcttcaac aacgtttcca aagtcttctt catgtcttgc gtttgattca gcaatccatt
    13921 cttcgattgt tttcatgtta attgccatac tgcgccccct ggttcgttca ttgctttatt
    13981 taaaaataaa tactatatga aaatataagc gataagtact atgttttcaa gggtaaacgg
    14041 tatattcgaa ataaagttaa atttcaaagt aatatactag gtgcatcgat ttcattatat
    14101 ttcaaacgtt tgaacgagac attcttcatc atcaattaac tgtgttttct catcaaattc
    14161 gatgtttatc tccccatata ctttcttcca aaaagaaact gctggtatat ttttcacaag
    14221 ttcgataacg aaatactgcc ctcgtttctc ttttagtaca ttcgcaataa cttgtttacc
    14281 gattcctttc cctttgtact gattcaatat gaaaatgtca tttataccaa agtcgttttc
    14341 cttcttcaaa aaaggacgtt ccagtagtaa caaaaatcct acaatatcat tatcactttt
    14401 aataaaatac ggagtgattc cgtcattttc ccaaaacatg tgcaaatctt cgtattcgaa
    14461 aaatccattt gcctcaatcg ttatattggg agtgaatgta gagaggtcat gaagatatag
    14521 tgcatacaaa ttacgcaata tttctttttc tgattcttga actatttgaa gtgttacaaa
    14581 catttttaaa gatccccttc cctatatgta actgtttctt cctctttatt attcgctaaa
    14641 aaagtttacc tacctttgca aaaaaaatag cactttaaaa agtgctattc cgctctcctt
    14701 gccgcttgct gaattgggtc ccacacgctg ttatatggtg gtgcgtaact taagtcgaca
    14761 tcttctaaat cgtgaatgct cattttattg aaaagtgcca ttgcgatcac atcaatccgt
    14821 ttatctacgc cttcttctcc aattacttgc ccgcccaaca attgtttcgt atcagagcga
    14881 tatagtattt tcaagtaaag tggttttgca tttggataat agcccgccat atttgtagaa
    14941 tctactttga ccgttttata cgggatatgt agcccttttg cttctttttc atttaagcct
    15001 gttcttgcga gcgtcaaatc cataaattta ataatacctg tgcctaacgt acctttaaat
    15061 gctcttcgtt tatcaagcat attcagtcca gcaagtcgcc cttgtttatt agcagtcgtt
    15121 ccgagcggga tatgatcatg aatttccttt ataacgtggt aatgtgttgc gcaatcaccg
    15181 gctgcatata cgtcttgcac attcgtttgc atatatgcat ttacttcgat tgctccttta
    15241 tgattcttac gtatatttgt cccttcaaga aaatcagtat ttggcttcac acctacagat
    15301 actaaaacaa gatctgcttt atacgtacct ttatccgttt cgactgcttc tactcgttcc
    15361 ttccctttaa acgcttttac attttcattc gttaaaattt caatatgatg cttatctgct
    15421 tctttatgta tgtactctgc catatctgca tcataaatcg taccgatatg atcatttcgc
    15481 tcaatcattc ttactttctt accaagttcg acgaatgttt ctgccatctc aagtccaatg
    15541 gcaccgccgc caataatcgt tacatcttca actttattcg tttctagcgt ttttaatatg
    15601 cgctcagcat caggaattgt ttttaaaagg tgaacacctt gcaaatctcg accttcccac
    15661 tctggcataa caggacgtac gccagttgca attaataaac gatcgtacgg aaattcaaaa
    15721 atatctttcg tcttcgtatg ctctgcgtac accactttct tttccgtatc tactttcgtt
    15781 acttcatgtc gtactttcgc atcaattcca tatttatcac gaaacgtctt cacattacgc
    15841 gcaattaatt tttccgttga agcgatagca ccactaatga catatggtaa cccacactgc
    15901 gcgtacgaat aaatttcacc tttttctaac gttacaacag ttgcattttc atcgtttcta
    15961 acaatttgca tagctgcact cataccagct gcatctccgc caataatgac atagttcact
    16021 ttaccactcc ttctttttta catactcttt acgttttcca tattttatag aaataacacc
    16081 tatttccatt gtaaagaaag agaattccat cttcaaattt ggtgcacaaa cctatgcctg
    16141 aataggtagc cgtcgtgtct cataaacaac atgtttaata tgctataaca gttactattg
    16201 aaagtaggtg aaatatatgt gcgccggcct tctcgcccag cttccagatg aaccgcaaga
    16261 accaaaagaa ccgaaacccg ccctctcact tgaccaagaa ttttccatta atgcgacaat
    16321 atacagcgct cgtgcctggt tatctaacga tgatacgttt gcgcaagata tttggaaagc
    16381 tacccaattc gcttcagcat cacatgctgg caagtctatc tttccagtcg gttcagttaa
    16441 aattctgaac ttctctgacg atacaataac tgttactgct tcaccagaat cagatcatgc
    16501 gctcaaaata gtcgtacccc cccattccga ggcagcccta acatctggtc ctttatcaca
    16561 tatacaagct agtacatcag gaggatcaag taaagtcaca tttctctttc acatcttttt
    16621 ctcaagggat cctggttcag ataaataacc ataaaaaagg tacagttatg cactgtacct
    16681 ttttcacatg tttattctct tgatttgatg agttcaacat tataagtttc aatatctgtt
    16741 agctttcctg taaaatatgg attttctcta taccaagatt gttttgaaaa atacgtttgc
    16801 atatctttcg tctgaaaaat atgtccatgc cttgcatata tttcatttct agcaattttc
    16861 aactgttctt tcgataaata tgctaaatct gtactcgtta attttcgaat atcactatct
    16921 gggaaaatga aaccattata tacatacgga ttggtagatg gcggagtaac attataaaca
    16981 actgtttttt ctgtactttt cttttgaaat ggaagattat aagacggaag tgccgttacc
    17041 gtttctacct tcgtcgtttc ccttccattt tctccatttc gttctaaata aatcgtcgta
    17101 cttccatcag tcgctatagg cccccatgta atttctcctc ctgccagtgc tgtaactggt
    17161 ttttgattta cgtacaatgt tgcaccaggc gcgttcgttt gaactgtaat atattgacct
    17221 tgcaacgtta aatctatcat tacgttattt tggctttgtt tcataagtac aaccttttcc
    17281 tcacgcgata gttttacata atcattttta tattctgatt gaaacacttg attgcccgga
    17341 agaaacggcc catattgctt ctcaaacttt ttgtcatctg tcttatcaat ttcttttccg
    17401 ttcattttta acgatacgcc tttttcattt gtaagcaaag tggtatagta cgtcttcact
    17461 ttcaatttat accgatcaaa tataaagaaa tactttccgt ctttcgttaa cgaaaaatca
    17521 gctctttcta ttccgtcccg ttgtttttca ccttgtctca aatattcttt taattcattc
    17581 acatacgatg gattttcttt tatatatgaa aatagaggcg ttaaactctc ttttgttatc
    17641 ataaccgatt gatcatctgc cgtaatgatc tcagctaatt tctctccgtc cctctcttgt
    17701 aaaatcgtaa tcatccgatc tacttgtgcc acctgcgtat aatacgatga tccgtacaaa
    17761 tataatccaa taatcgctat aacaaatagt gctaacagtg taatgccaac ctttgcacca
    17821 ccgctcatgt tcttctttac tacaggactt cccctcttcg tcccgcagtt ttgacaaaat
    17881 tgcacaccat cttcaaactg aattccgcac tttgtacata cattcatcca gtcaaccacc
    17941 ttttcattag aagccagtta ttccctgtgt taaggcttga attatcgtgc taatgtaaga
    18001 ccaaagtaca ataaatgttg caattccaat taaaacattt gcaataataa gtgtgtacac
    18061 gagatctaat ccgccattgt ctagctttaa tatggctaca gttatactaa tccctatata
    18121 agttgcagct accgataata atatcggtaa gaaaaagatt aataagaaac taaaaagaaa
    18181 agaaaggact aatatagcaa tagccggcgt cgctagcgtt ccccatatac cgaatacttc
    18241 aagaaacgaa aaagatgatt tcatcatctt accacttaca aaaataataa atccgacaaa
    18301 taaagttaaa attaataaaa agaaaaagac cgttatagat tctacaaaaa atgtgggagt
    18361 agatatatct ggtgcaaatg ttctcgtaac tgctgatgct gcactcatca ttctataaaa
    18421 aatacatgct cctaaaaaac aaataagaac aagacttaca attccatttc ttacttcaat
    18481 cgtgccgctt ttcataatcg ctgtcggtgc ttgtaatgca tgtttaaaaa attgaaaata
    18541 gccgctcgca aaccgcttcg cttgctctac cgtttcattt ggccgagttt cctttacttg
    18601 tgccgcgcgt gcttgttccg gcccttcttc ttgaccacta cttgccacta cttcttccgt
    18661 taacgaatgt ccacaattcc cgcaaaactt tgcctctgct gcattttctg tatgacatga
    18721 cggacatttc attctctcat ccctccttaa gcatatacca tatagggtgt tacaaattca
    18781 atatatgact ttgtacataa aacatgacta caagaaaaag attctgaaat ccttctttca
    18841 aaagaaatta tatatgctag caatcttgaa aaataatgct attatgaaac agaacaaata
    18901 acatttttaa cagattggat gaaagacaat ggaattggta aactcaattt ttcaaatact
    18961 ccttacaagc gtaatccaat tattttcctt aattggcgtt atcattgtaa ttggatttct
    19021 attaggttat ttagaatcac taacacgaat gtattggtcg agggctttcg gaagaaaagg
    19081 attcctttta accgcgtgga ttggtgttcc gatccacgaa cttggacatg ccattatgtg
    19141 cgtactgttc cgtcataaaa ttgtagcaac gcagtttttc ccaacagata caagtcaagg
    19201 agcattaggt tacgtacaac atcaatacaa tcaaaaaagt gtgtatcaac gaattgggaa
    19261 tttcttcatc ggcatcgggc ctattatttc tggtattact gcattaatcc ttttaatgcg
    19321 ctatttcgta ccagaatcat attttttatt taatacaact ctcgaaaaaa cgatcgcttc
    19381 tacttctatt aatgtagaaa tgattcaaaa catgctcttg tcgacgtttg tattattgaa
    19441 aagcttattt acaatcggca atttattgaa tccttccttt tggttatttt tatttatcgc
    19501 catttgtatt tccgcacata tcgctttaag taaaccagac attaaaggat caatagacgg
    19561 agttatcgtc atgtttatcg ttttattttt attcaacatc atagcgggac tgtttcaata
    19621 cgacagtaac cagctaattg gacaggttat gaaatataat atgtatctca ttgcgttttc
    19681 tagtgtagca ctgcttttct cttgtctttc tacactcgtt agtttttcgt tttataaaat
    19741 aagaagaggg tgttcttttt gaacgccctc ttcttattaa ttattcccct tataatcaca
    19801 atgctcaaca ggcacacgag catgcccttc ttcatcggta caccatgact gtgattggaa
    19861 tgcaagaaag ataccaatcc attcttcttc cttttcaaag tgaatgagta tccctccgtc
    19921 ttgccatatg ccattatcac ctttccattt ctctacattc ccttgattca tgtgaatatc
    19981 atgtataccg tttcctggtt tgaaatgaaa ataggaatct ggtgtgtttt cttctggtcc
    20041 ccatctttca ccaaacgcgt aaataatcgc tttttcttct atcgctcgct ttatataacg
    20101 ttctattttt tcgtttaaat cattatctgc tcctgctttt tcgggaggca aaggaatcat
    20161 ttgttttgaa tcaaatagat ttcctcttac ataatctaaa gccactttcg gttcattgtt
    20221 ttttatttct gtaaaaccga atggtaatgt cggtaaaata tgaatcgctt ctgatttaat
    20281 attgttactc gcaaaatata aaacttctga cggataactt tgcgatttta cgttaattgc
    20341 aatacgataa tctactccta cttcatcttg taaatgaact tgataatgag gtgttttccc
    20401 ttttccaatc tttgattgta taactgtacc ttttaacaca ccgtagtttt ttaggggcat
    20461 acatttcatc tcctattcat ttagtagaag ctattcatat ttaaatcatt atccactcat
    20521 aaaaaaaatc ctcctatgtt agggggattt ttaatttctc aacatatacc aaacaataac
    20581 ctctaccact acaagtaaaa ccgcaccaaa gatcattaac gtcgtcttct ttaatagttc
    20641 attttcacgg taagggatat tacataagta agcacctaat gtaatccgtg atggacaagc
    20701 gattgtcgct actgatgatg cggtgttttg aagtgttgtg acatattgcc acgggagtgc
    20761 tacgttttgt gcggtttgca tttgtagttt tataaacatt gcatttgatc ctgcgttact
    20821 acctgttaaa aatccaccaa tagcgccaat aaacggagca acaaaaacga aaaaggttcc
    20881 aaatgtttca ccagctgttt ttgcaagtaa tgaatgcatg ccagatgcac ccattagttc
    20941 tgaaatggcg ataaacattg tcgtcgtaat agcaaatgga atccattgtt tgatcgtttg
    21001 tgagaatgat tgtttaataa tattagacgg gatgcggaag aaaataatag taaataagca
    21061 agtcataccg agccaaaatc ctggtgaata tagtaactct agtttataag agtatgattt
    21121 caaatcaaga accgcatatg atctgaacaa atcatgtaat gctggaacga ggcgagaaag
    21181 taaaatacaa actgttagaa atatataagg gctaataatt tttataatgg atacttctct
    21241 ctccgttgca gcggcatgtt ctgttataag attttgccca ctttttcctt ttaatttaat
    21301 gataagaaag ccaaatgtaa tcgtaacgat agaacttaat atcccggcta gttcaacact
    21361 tacgtacgca ttagaaagat atattccgag agaaaataat agaaagaacc ctactccttc
    21421 tttccacttt tctataaccg cttgccagcc gccaacaacg tgtaaagaaa gaataacgaa
    21481 gtaagcaaac atcggaatac ttaatagcgc tgtatttgta ccaagtgttg taagaggcat
    21541 atttattagc tgcgaaccga taatcgtacc cgttgccatt gcgccccatg aactagctag
    21601 taagccgata aatgagagca gtacagcttg aaatggttta tatcctagtg aaagaaaaat
    21661 aggtgctgca accatgaagc caattccgaa tccacttacc gattcaatta gtgggcaaat
    21721 accaaagcac ataagaagca tttgtaataa acgatcttgc gtcacttctt ctaaaaaacg
    21781 cgctacttgg tcgatgtacc ccattttgtt catgaggtga aataaaaaaa taccgaaaaa
    21841 taaaacgtac ccgacaataa aacaaattaa ccatccttta atcgttgcgt gcacagtttc
    21901 acttatccct aattgaaaca ttggcgagag taaaacgatt ccaacagaca cagcataaga
    21961 aattaacgaa gaccttaatg acgtttgttt aaataaaaat aaacaaatga aaatcatcat
    22021 aattgggata agtgccaaca atatggccat gttatcatct catttcgttt aaaatacaat
    22081 ttttaactat tatataacag atgttgtaat tttcaattgt ttttaagaca gatttaaaaa
    22141 aggagccaaa cggccccttt tcattcactc ccattttcta ttatcctgaa aaactgtctg
    22201 ctgtccgatt atttttttca acacaacaaa cacaatgtaa gtacatattg cttgcaatgc
    22261 aatattccaa aatttcatta atgtaaatga atgaatccgt agaaataatt cgtttaataa
    22321 tacaatcgaa acgatactaa ataattctat actaatcgaa aatagacata tttctaaaat
    22381 agactgttct tgaatgcgat ttaagttgga aaagataaat acatatccta aaaatagagc
    22441 catcaactct attttcgtca tgctaatgag ccaagcgtat agtggtatag ttaaaagaag
    22501 atacagtaat ttgcgtctta gcatgccttc tcacctctga attaaatgta ttttctgtat
    22561 attttaacat ttattacgca aaacaaaaag aagagactta cgcctcttct ttttgttttg
    22621 ttgcatatat taattcacat atttcttctc gtttttcatt ttctaaaagc tcaatgatct
    22681 tacttccaac aacaactccg tcacatattg taaccatttc ttctacatgt tcttttgttg
    22741 aaataccgaa tcctgcgact actggtaagt tgacgtgtga ttttactttt tctaagtaac
    22801 tacgaatctc ctctttaaag ttttgacgta ctcccgttac gcccgctact gtaacagcgt
    22861 agacgaatcc ttctgattca ctcgtaattt tttcgattcg ctcaattggg ctcgttacgg
    22921 taacgagtgg aattagcgca atgtttgcct ctcgaagtaa cggcgtaata atattttgtt
    22981 cttcatatgg taagtctgga atgatgatgc cgtctacacc tgcttctatg cagttttcga
    23041 tgaatcgttc ttttccaaat gcgagtactg gatttaaata tgtcatgagt acaaacggaa
    23101 tttgcacttc ttcccttacc tctattaatg cttgaaaaat tccttttact gttataccgc
    23161 tatctagcgc tcgcttccct gctctttgaa tcgttgggcc atctgcaact ggatctgaaa
    23221 acgggatacc aatttcaacg atgcttgctc ctgcttcgtc tagaaaacga attctttctt
    23281 ttaatttctc aagtccacca tctccgccca ttacgtacgg aataaatgct ttcttaccat
    23341 tttcaaacgc tgctttaatt ttttctactc ccatttttca cacctcttcc atataacgtt
    23401 ttatactctc tacatcttta tcaccgcggc ctgataagca aatgacaagt ccttcgtctt
    23461 tcttcatttg cggcgctaat tttaatgcat atgcgacagc atgtgag
//
