LOCUS       NZ_KB976300            25239 bp    DNA     linear   CON 14-JAN-2024
DEFINITION  Bacillus cereus K-5975c achrv-supercont1.1, whole genome shotgun
            sequence.
ACCESSION   NZ_KB976300
VERSION     NZ_KB976300.1
KEYWORDS    WGS; RefSeq.
SOURCE      Bacillus cereus K-5975c
  ORGANISM  Bacillus cereus K-5975c
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5209568)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     The Genome Sequence of Bacillus cereus K-5975c
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5209568)
  AUTHORS   Feldgarden,M., Van der Auwera,G.A., Mahillon,J., Duprez,V.,
            Timmery,S., Mattelet,C., Dierick,K., Sun,M., Yu,Z., Zhu,L., Hu,X.,
            Shank,E.B., Swiecicka,I., Hansen,B.M., Andrup,L., Walker,B.,
            Young,S.K., Zeng,Q., Gargeya,S., Fitzgerald,M., Haas,B.,
            Abouelleil,A., Alvarado,L., Arachchi,H.M., Berlin,A.M.,
            Chapman,S.B., Dewar,J., Goldberg,J., Griggs,A., Gujja,S., Hansen,M.,
            Howarth,C., Imamovic,A., Larimer,J., McCowan,C., Murphy,C.,
            Neiman,D., Pearson,M., Priest,M., Roberts,A., Saif,S., Shea,T.,
            Sisk,P., Sykes,S., Wortman,J., Nusbaum,C. and Birren,B.
  CONSRTM   The Broad Institute Genome Sequencing Platform, The Broad Institute
            Genome Sequencing Center for Infectious Disease
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2012) Broad Institute of MIT and Harvard, 7
            Cambridge Center, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: allpaths v. R38749
            Assembly Name                     :: Baci_cere_K-5975c_V1
            Genome Coverage                   :: 150.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/14/2024 01:11:31
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,396
            CDSs (total)                      :: 6,275
            Genes (coding)                    :: 5,989
            CDSs (with protein)               :: 5,989
            Genes (RNA)                       :: 121
            rRNAs                             :: 9, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 8, 5, 4 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 96
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 286
            CDSs (without protein)            :: 286
            Pseudo Genes (ambiguous residues) :: 0 of 286
            Pseudo Genes (frameshifted)       :: 113 of 286
            Pseudo Genes (incomplete)         :: 198 of 286
            Pseudo Genes (internal stop)      :: 95 of 286
            Pseudo Genes (multiple problems)  :: 94 of 286
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:03:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3052725
            Orig. end                         :: 3077964
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            KB976300.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Please be aware that the annotation is done automatically with
            little or no manual curation.
FEATURES             Location/Qualifiers
     region          1..25239
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="6"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25239
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25239
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15239](-)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15239)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            complement(603..1340)
                     /locus_tag="IGY_RS15380"
                     /old_locus_tag="IGY_03070"
     CDS             complement(603..1340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129475.1"
                     /locus_tag="IGY_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03070"
                     /product="MTA/SAH nucleosidase"
                     /protein_id="WP_016077665.1"
                     /transl_table=11
                     /translation="MTIGEVKRVMKRIAIVSAWEPELTYLHQHYPSERFEKRAAWEFHF
                     HTINELEIISVVTGVGKVSCASCVQLLISEFQPDELFMTGICGSLSNKVKNGHIVVALN
                     AIQHDVTAAGSGEDVFNLYNGRTAPIETTKSLVRRIKKIRLYDPIHFGTFLSGDQRIRS
                     SEMRYLLHTVYGALAVDQEVAAFAYVCQINKKPFLCLKAASDQANDKTKEEQKIFKMLA
                     CERACEHLIAFLRVYEINVVNNR"
     gene            complement(1337..>1642)
                     /locus_tag="IGY_RS33825"
                     /old_locus_tag="IGY_03071"
                     /pseudo=""
     CDS             complement(1337..>1642)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002156408.1"
                     /locus_tag="IGY_RS33825"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03071"
                     /product="DUF3885 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="LYCTYQFSLKCLAEDIKYESLIQAANHEDFSVLYPRFGRKKEISY
                     PDVFLINATKDIVMFMYDDRGCEVIAKNKEIIRDLYKKYKEWIPDYERESIDNLFK"
     misc_feature    complement(1702..1716)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    1704..1718
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     gene            complement(<1784..2155)
                     /locus_tag="IGY_RS15390"
                     /old_locus_tag="IGY_03072"
                     /pseudo=""
     CDS             complement(<1784..2155)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002110027.1"
                     /locus_tag="IGY_RS15390"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03072"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MQLKEYMNQTFPGVTLVPYLYSQWGNHLYFDFGKDKYQIVEGTDD
                     LNMEYFSQLYTYNKFLFEDIFSKEDVVFVVTNVYRFKKENTKTPQKINVYNKYIKKRDL
                     RFHIRQETLPFLFEDEEADL"
     gene            complement(2169..2776)
                     /gene="yqeK"
                     /locus_tag="IGY_RS15395"
                     /old_locus_tag="IGY_03073"
                     /pseudo=""
     CDS             complement(2169..2776)
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000965880.1"
                     /locus_tag="IGY_RS15395"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03073"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLYNDIYSFAPTGKIDNDIKDFLLKYNKEFTYKHSIRVANEAKKI
                     AEKFHVDKEKAAIAGYLHDISGIFPNEERIAVAEEFGVEIEEAERKFPMIIHQKLSRVI
                     AKEIFKVEDEDVLDAICCHTTLRKHPTKMDLVLFVADKIEWDQKGTPPYLIEIKKDWKN
                     LWKKLLLYIFHICGKGKIH"
     gene            2969..3664
                     /locus_tag="IGY_RS15400"
                     /old_locus_tag="IGY_03074"
     CDS             2969..3664
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="IGY_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03074"
                     /product="response regulator transcription factor"
                     /protein_id="WP_001038807.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQKVSTY
                     EVDLMILDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVINGEKFIHTV
                     WGVGYKIEK"
     gene            3654..4811
                     /locus_tag="IGY_RS15405"
                     /old_locus_tag="IGY_03075"
     CDS             3654..4811
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="IGY_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03075"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_001243304.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIYRLVTSVIES
                     SLTLTELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYLHEKKLYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELAIGVNEIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQFQEANIECRPSFPSQKLMVLADGEKLVRV
                     FENLIINAIAYGSEGRYIDLTAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDEKTTFTVKLLPYKC"
     gene            4987..6003
                     /locus_tag="IGY_RS15410"
                     /old_locus_tag="IGY_03076"
     CDS             4987..6003
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="IGY_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03076"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_001160046.1"
                     /transl_table=11
                     /translation="MQFLKKFAILLLSFFITALIVLYFYLYVNGPIIQAKSAILINANS
                     GEIVYKKNEETPVQSAALSKLMTEYIVLEQLNDRKIQLDDFVQISNEVFRVETSPIQVT
                     SNDKTTVRDLLHALLLAGNNRSALALAEHIAGNEDNFTILMNKKAKELKLLQPSPFLNS
                     TGINNDTNKQSTTTAIDAAKLAARLVKDFPDVLNITKLTSYQFTFKDSQVFNTNKMIYS
                     LNENIKLQGVDGLQTSFSTNGNYSFVSTAKLGDTRLISVILDADEENISFIETKKLLQY
                     GFDPSSCSALQAFKDAVTSWAVLLQFKNLIIQTLLVFFIITILMFLHIRQKKSEDFN"
     gene            complement(6101..>6175)
                     /locus_tag="IGY_RS33830"
                     /pseudo=""
     CDS             complement(6101..>6175)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="IGY_RS33830"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="damage-inducible protein DinB"
                     /pseudo=""
                     /transl_table=11
                     /translation="VLRHVMGYEIHHIGQLSIWARELN"
     misc_feature    6179..6188
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            6341..6478
                     /locus_tag="IGY_RS32300"
                     /old_locus_tag="IGY_03077"
     CDS             6341..6478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000376553.1"
                     /locus_tag="IGY_RS32300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03077"
                     /product="DUF3956 domain-containing protein"
                     /protein_id="WP_000376554.1"
                     /transl_table=11
                     /translation="MDSCVVFVNGQPFLVLSVAGIEIARLEISLQVALALRVLGIPICD
                     "
     gene            complement(<6835..7097)
                     /locus_tag="IGY_RS15415"
                     /old_locus_tag="IGY_03078"
                     /pseudo=""
     CDS             complement(<6835..7097)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="IGY_RS15415"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="IGY_03078"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MYTLFQYNWQVRDEWFKRCEQLSEEDLLCKLVVF"
     gene            complement(7149..7709)
                     /locus_tag="IGY_RS15420"
                     /old_locus_tag="IGY_03079"
     CDS             complement(7149..7709)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002103120.1"
                     /locus_tag="IGY_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03079"
                     /product="AAA family ATPase"
                     /protein_id="WP_000369207.1"
                     /transl_table=11
                     /translation="MDNKTKIISVAAVSGGGKTTITERLKHEFKNSKALYFDSYTFDNC
                     PADICKWIDDGANYDEWVLTPLIHDIEQLIQNNSLDYIIIDYPFAYLNSEMRKFIDVTI
                     FIDTPLDIAMARRILRDFKEGTIDEIHNDLEHYMTYARKAYLEAIHTVKPNSDIILDGS
                     LSVSEIINHAVEELGRREVIVNG"
     gene            complement(7765..8298)
                     /locus_tag="IGY_RS15425"
                     /old_locus_tag="IGY_03080"
     CDS             complement(7765..8298)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002007691.1"
                     /locus_tag="IGY_RS15425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03080"
                     /product="GNAT family protein"
                     /protein_id="WP_016077669.1"
                     /transl_table=11
                     /translation="MMYERSKEVIKLETFKKSDFKQLINWINSEEFLIQWSGNAFTFPL
                     DEQQLEKYIESANTFAFKVVDEETSDVIGHISLGQIDNINKSARIGKVLVGNTKMRGRS
                     IGKHMMKAVLHIAFDKLKLHRVTLGVYDFNTSAISCYEKIGFVKEGLLRESKKVGETYW
                     NLWEMSMLEYEWKK"
     misc_feature    complement(8374..8389)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.06"
                     /tool="antismash"
     gene            complement(8404..8760)
                     /locus_tag="IGY_RS15430"
                     /old_locus_tag="IGY_03081"
     CDS             complement(8404..8760)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535569.1"
                     /locus_tag="IGY_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03081"
                     /product="hypothetical protein"
                     /protein_id="WP_016077670.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWEVFEECKKEQHEKCDNSCVQGIRDE
                     LKKLINRTVQINTEGRTYVGTVSSVSCDVVRLAAIPGSVAVIISICKIEAIFPPITTVT
                     ADFDFNGIDVANKA"
     gene            9326..9691
                     /locus_tag="IGY_RS15435"
                     /old_locus_tag="IGY_03082"
     CDS             9326..9691
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="IGY_RS15435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="IGY_03082"
                     /product="hypothetical protein"
                     /protein_id="WP_080117655.1"
                     /transl_table=11
                     /translation="MKGGRNECPGKMIAGVLRKSIVVMIGGNLKKSVIVMMIGVLRKSI
                     VMMIGGNLKKSVIVMTIGVLNEISVVVNVSLFVAIVKEKIGNIFNVNVKERICLLEPIG
                     LFRKVDPSPTSLLLLNF"
     gene            complement(10001..11941)
                     /locus_tag="IGY_RS15440"
                     /old_locus_tag="IGY_03083"
     CDS             complement(10001..11941)
                     /NRPS_PKS="Domain: AMP-binding (99-521). E-value: 4.1e-82.
                     Score: 267.9. Matches aSDomain:
                     nrpspksdomains_IGY_RS15440_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="IGY_RS15440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03083"
                     /product="AMP-binding protein"
                     /protein_id="WP_016077672.1"
                     /sec_met_domain="AMP-binding (E-value: 7e-88, bitscore:
                     293.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNDGTCNVVESALSRWLADEETRIQPALQ
                     YEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDEVKGEVCHCFVVLRDHVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     CDS_motif       complement(10346..10408)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGY_RS15440_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="IGY_RS15440"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     aSDomain        complement(10379..11644)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGY_RS15440_AMP-binding.1"
                     /evalue="4.10E-82"
                     /label="IGY_RS15440_AMP-binding.1"
                     /locus_tag="IGY_RS15440"
                     /protein_end="521"
                     /protein_start="99"
                     /score="267.9"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QPALQYEGENGTSKSFTYEELDNWVSRVANGLKHAGIEKGDRVTI
                     YMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKIV
                     SLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMQSDDPL
                     MLIYTSGTTGKPKGTVHTHAGFPLKAAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFG
                     SLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLK
                     SLEVFASTGEPWNPDPWMWLFETVGKGNVPICNYSGGTEISGGIFGNVLIKPIAPISFN
                     ASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVH
                     GDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       complement(11099..11155)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_IGY_RS15440_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="IGY_RS15440"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     gene            complement(11991..13532)
                     /locus_tag="IGY_RS15445"
                     /old_locus_tag="IGY_03084"
     CDS             complement(11991..13532)
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="IGY_RS15445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03084"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_000886744.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGSRTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFDKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            complement(13535..14323)
                     /locus_tag="IGY_RS15450"
                     /old_locus_tag="IGY_03085"
     CDS             complement(13535..14323)
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 5.5e-75. Score:
                     243.8. Matches aSDomain: nrpspksdomains_IGY_RS15450_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="IGY_RS15450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03085"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_016077673.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRARQANSLSLALLDELQTILTQI
                     SEDSSARVVILTGAGEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPTYKGE"
     aSDomain        complement(13562..14281)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_IGY_RS15450_ECH.1"
                     /evalue="5.50E-75"
                     /label="IGY_RS15450_ECH.1"
                     /locus_tag="IGY_RS15450"
                     /protein_end="254"
                     /protein_start="14"
                     /score="243.8"
                     /tool="antismash"
                     /translation="HVVKISLNRARQANSLSLALLDELQTILTQISEDSSARVVILTGA
                     GEKAFCAGADLKERADMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPANLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            complement(14328..15239)
                     /gene="mvaB"
                     /locus_tag="IGY_RS15455"
                     /old_locus_tag="IGY_03086"
     CDS             complement(14328..15239)
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="IGY_RS15455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03086"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_000775428.1"
                     /sec_met_domain="HMGL-like (E-value: 2.1e-47, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISATAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            complement(15261..15476)
                     /locus_tag="IGY_RS15460"
                     /old_locus_tag="IGY_03087"
     CDS             complement(15261..15476)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="IGY_RS15460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03087"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            complement(15503..16840)
                     /locus_tag="IGY_RS15465"
                     /old_locus_tag="IGY_03088"
     CDS             complement(15503..16840)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="IGY_RS15465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03088"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486743.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.6e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.4e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.8e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.5e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIASGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITNLTLPSNVRIDHFLENHVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDEVFKEGIYTTGFVTKQLVKK"
     gene            complement(16856..18001)
                     /locus_tag="IGY_RS15470"
                     /old_locus_tag="IGY_03089"
     CDS             complement(16856..18001)
                     /EC_number="1.3.99.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="IGY_RS15470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03089"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_016077674.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.7e-39, bitscore:
                     133.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.3e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.5e-56, bitscore:
                     189.0, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDDDEYVISGEKCWITNAEYA
                     NTIIVTAVNGIEENGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEIERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            complement(18218..19186)
                     /locus_tag="IGY_RS15475"
                     /old_locus_tag="IGY_03090"
     CDS             complement(18218..19186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="IGY_RS15475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03090"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_016077675.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNGEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGENRLVQPSTREDVTGKMEQFSNDFLQTISDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGAGLFGGAVVKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAYYKMIKHNKNMKDLVSFQSDNKYLFMAYNQVKQKELGRIIANHKNEKIEVVFE
                     NYEKTLYELFMRTPRYTSNVNVCEHIFGYFKTKLKKQEKDHFIELLQKYAEKKIPLSSL
                     LTILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            19420..19719
                     /locus_tag="IGY_RS15480"
                     /old_locus_tag="IGY_03091"
     CDS             19420..19719
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="IGY_RS15480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03091"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_000728151.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIMFLGTSAQAEYDGNNMNRVNNTDISTRVN
                     DNNLDRVNNDVRTRNVNTTNDLNDNRDRNNNWAWLGLLGLAGLLGLRRRDKETR"
     gene            complement(19842..20495)
                     /locus_tag="IGY_RS15485"
                     /old_locus_tag="IGY_03092"
     CDS             complement(19842..20495)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168192.1"
                     /locus_tag="IGY_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03092"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_001168192.1"
                     /transl_table=11
                     /translation="MQKDWLEELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQTFAKEIFKSEYESYEGLL
                     RVVIHNRFKFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQEEGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWNDEAEIENTIQFILYGLTPRI"
     gene            complement(20520..21539)
                     /locus_tag="IGY_RS15490"
                     /old_locus_tag="IGY_03093"
     CDS             complement(20520..21539)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="IGY_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03093"
                     /product="ABC transporter permease"
                     /protein_id="WP_016077676.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYI
                     PQIAVVDMPAQIVKVMKDQEASIYEYSKEKAISELEKQTVDAVLRIENGKMKLLLEGSD
                     SSKNRAVLQVLQKSIENNEVSIMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVAGYIIGFGIFAFIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPMESMNKW
                     LQMLGKVFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSILFAVGNVFALKKHRKI"
     gene            complement(21536..22261)
                     /locus_tag="IGY_RS15495"
                     /old_locus_tag="IGY_03094"
     CDS             complement(21536..22261)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001187059.1"
                     /locus_tag="IGY_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03094"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_016077677.1"
                     /transl_table=11
                     /translation="MQQLSIILRTVSKSFGKKEVLHNLSLQVEKAEIFGFVGPSGSGKT
                     TLIKMIAGINEATKGEVLVNNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKKRIAEVFELVQLSQYMKKQVQQFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVAVGTTEELKK
                     RVSSGRIEDVFLLEEVVPS"
     gene            complement(22449..22700)
                     /locus_tag="IGY_RS15500"
                     /old_locus_tag="IGY_03095"
     CDS             complement(22449..22700)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="IGY_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03095"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     gene            complement(22915..23757)
                     /locus_tag="IGY_RS15505"
                     /old_locus_tag="IGY_03096"
     CDS             complement(22915..23757)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="IGY_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03096"
                     /product="metallophosphoesterase"
                     /protein_id="WP_016077678.1"
                     /sec_met_domain="Metallophos_2 (E-value: 9.6e-08, bitscore:
                     30.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKINRIVMIICIVVGFTIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKQFGDNQDVLIQKIKSIDPDIIAITGDLIDSKSYDAEVSMQLIREI
                     VKKYPVYFVTGNHEQWSGKYNNLEKELKKYDVNVLRNEHVGIRKGEQEINLLGIDDPEF
                     VTGNGDEGNIIIDEIKKTKIEMQPDRYNVLLSHRPEFIKEYTNERLDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGVLPKYTAGLYIEQNTSMVVSRGLGNSIIPQRILNRPEIVVVQLN"
     gene            complement(24018..24944)
                     /gene="bla"
                     /locus_tag="IGY_RS15510"
                     /old_locus_tag="IGY_03097"
     CDS             complement(24018..24944)
                     /EC_number="3.5.2.6"
                     /codon_start=1
                     /gene="bla"
                     /gene_functions="resistance (resist) ClassA"
                     /gene_kind="resistance"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002101021.1"
                     /locus_tag="IGY_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="IGY_03097"
                     /product="class A beta-lactamase Bla1"
                     /protein_id="WP_016077679.1"
                     /transl_table=11
                     /translation="MVLKNKRMLKIGICVGILGLSLTSLEAFTGGALQVEAKEKTGHVK
                     HKNQATHKEFSQLEKKFDARLGVYAIDTGTNQTISYRSNERFAFASTYKALAAGVLLQQ
                     NSIDTLNEVITFTKEDLVDYSPVTEKHVDTGMKLGEIAEAAVRSSDNTAGNILFNKIGG
                     PKGYEKALRQMGDRITMSDRFETELNEAIPGDIRDTSTAKAIATNLKAFTVGNALPAEK
                     RNILTEWMKGNATGDKLIRAGVPTDWVVGDKSGAGSYGTRNDIAIVWPPNRAPVIIAIL
                     SSKDEKEATYDNQLIAEATEVIVKALR"
ORIGIN
        1 attcattatt ttagtcaaat catttaaatt ataataagaa agatcgtaca ctttttcata
       61 gcccaactta ttataaaaat gaatcgctcg gtcgtttcct acaatgactt cgagaaaaag
      121 ttgcttacat ccatgttgaa tcgcctcttc tttatgcagt tcaaataatt tttgactcac
      181 accaataccg cggtaattag gatgaaccgc taatgttcca cagcgcatag tctttatact
      241 ttcataatcc tttataccac ctaatattac gccaactgat ttgtcaccgt ctaaagcaag
      301 aaaagaatgt tctagcaaat taccttctgg tccaaaaaaa cgttgtataa aaccctcttt
      361 tgaaacttcc atcttaataa tataatcgga aaatccatct ttaaaagctt catatactaa
      421 atcaatattt acttcactac accttttata ttgaatcata taaaattgcc ctccaattgc
      481 ttgtattaac ctcaacatgt acccatataa tatattccat ctattataaa tttcagctct
      541 taatttgaaa tgaacggaca tttccctaca tataacttac tattaatttg ttttataaca
      601 aactatctat tatttactac attaatctca taaacacgta aaaaagcaat taaatgctca
      661 catgctcttt cgcatgctag cattttaaag attttttgtt cttctttcgt tttatcattt
      721 gcttgatctg aagcagcttt taaacataaa aatggttttt tatttatttg acacacatag
      781 gcgaaagctg ctacttcttg atcaactgcc aatgctccgt atacagtatg aagtaaatat
      841 ctcatttctg aactacgaat acgttgatct ccagataaaa atgtaccgaa atgtatcgga
      901 tcatacaatc gtattttttt tattcttctt acaagtgatt ttgttgtttc aataggtgct
      961 gttctaccgt tatataaatt aaaaacatct tctcctgagc cagcagcagt aacatcgtgt
     1021 tgtattgcgt ttagtgctac tacaatatga ccgtttttca ctttgtttga taaacttccg
     1081 catattcctg tcataaacaa ctcatctggc tgaaactcac taattaacaa ttgtacacaa
     1141 ctagcgcagc ttactttacc gacaccagtt acaactgata taatttccag ctcattgata
     1201 gtatgaaaat gaaattccca agctgctctt ttttcaaaac gttcactcgg ataatgttga
     1261 tgcaaatacg tcagttctgg ttcccatgca gatacaattg caatacgttt cattacacgc
     1321 ttcacttccc ctattgtcat ttaaataagt tatctatact ttctcgttca taatctggaa
     1381 tccattcttt atatttctta tataaatctc gtattatttc tttattcttc gcaattactt
     1441 cacatcctct atcatcatac ataaacatga caatatcttt cgttgcattt atgagaaata
     1501 catctggata agaaatttct tttttccgtc caaatcgagg atacaaaaca gagaaatcct
     1561 catgattagc agcttgtata agcgattcat atttaatatc ttccgcaaga cattttaaag
     1621 aaaattgata tgtacaatat aatgtgaaac tttaatcagt tcatccccca ctgattatca
     1681 gccctcacca atcgggcttt taggggcagc ccgcccccca cctatcttct ttgctttcgc
     1741 tgaattttga ggtgggggtc ttactgcccg gcaaatagcg ggataaatct gcctcttcat
     1801 cttcaaatag aaacggtaac gtttcttgtc ttatatgaaa tcttaaatct cttttcttaa
     1861 tatatttatt gtatacattt attttctgtg gagtttttgt gttttccttt ttaaatctat
     1921 aaacatttgt cactacaaac actacatctt cttttgaaaa tatgtcttca aataagaatt
     1981 tattatatgt atatagctga gaaaagtatt ccatatttaa atcgtcggtt ccttctacaa
     2041 tttgatattt atcttttcca aaatcaaaat acaaatgatt tccccactga gaatataagt
     2101 acggtactaa tgtaactcct ggaaatgttt gattcatata ttcttttaat tgcatttcct
     2161 tgtcccttct actgtacaat tctttttaaa taccaatatg cttcttctag ccacggatgt
     2221 ataactttca atgtatcttt cctttcccac aaatatgaaa tatatacaaa agcagctttt
     2281 tccaaagatt tttccaatcc ttttttattt ctattaaata tggtggtgtc cccttttgat
     2341 cccattctat tttatctgca acaaataaaa ctaaatccat ctttgttggg tgtttacgca
     2401 gtgtagtatg acaacaaatt gcatctaata cgtcttcatc ttctacttta aatatttctt
     2461 ttgcgattac tctcgatagt ttttgatgaa taatcatagg aaactttctt tctgcttcct
     2521 ctatttctac cccaaattct tcagcaactg caatccgctc ctcgttcgga aaaatgccac
     2581 taatatcatg taaatatcct gcaattgctg ctttttcttt atctacgtga aacttttctg
     2641 caatcttttt tgcctcattt gccacacgaa ttgaatgttt atatgtaaac tctttattat
     2701 attttagtag aaaatcttta atatcattgt ctatttttcc agttggagca aatgaatata
     2761 tatcattata taacatagaa aatccccctt ataactaact ttcagtataa tgcagaattt
     2821 aaatattttt gttattttat attcgttatt aatcttttta ctccttttta atacgttaca
     2881 tgaaatttta tacagaatca ttgctacaag tacataaatg tttgatatta tagtaatgtt
     2941 gatgatttgt aaggaaagga actacaaaat gaataaaaac atattaatta ttgatgatga
     3001 taaagaaatt gttgaattac ttgctgttta tttgcgaaat gaaggctata acatttataa
     3061 agcttatgat ggcgatgaag cattgcaaaa ggtttctaca tatgaagttg accttatgat
     3121 tttggatatt atgatgccaa agcgaaacgg attagaagtt tgtcaggaag tgcgtgaaaa
     3181 taatactgta ccaattctaa tgcttagtgc aaaagcagaa gatatggata aaatattagg
     3241 tcttatgaca ggtgccgatg attatatgat caagccattc aatccattag aattagtagc
     3301 aagagtgaaa gctttattac gaagatcctc tttccaaaac gctacttcgc aaaagaatga
     3361 agatggtatt attcgtattc gctctgttga aatacacaaa cataatcata ctgttaaagt
     3421 aaatggagag tatattaaat taacctctat tgagttcgat attttatatt tacttgcaag
     3481 taatacagga agagtattta gttcagaaga aatttttgaa cgcgtttgga atgaagatgg
     3541 ttacggttca aataagactg taatggttca tattagcaac ttacgggata aacttgaaac
     3601 agtaataaat ggagaaaaat ttattcacac tgtttgggga gttggctata aaattgagaa
     3661 atgaagcatt tgatatatta aaagatatcc ctaaatggaa acttattttt tggctcttat
     3721 tagctatcac actcacgcct attactgagt taattattta tcgcctcgtt acgagtgtaa
     3781 ttgagagttc acttactcta actgaacttg gtaaagaatt cattcgaatt tttggttatg
     3841 aaaagtataa agggattaaa gaatcgttat ggatgatgat tgtatcttat ttgtttttat
     3901 tttctatttt ttcatcctat ctttacattt tttatcttca cgagaaaaaa ctttattatg
     3961 aaacttgtat taaaaaaatg atagaagaaa ttcgttatat tgcaaatgga aacttcaatc
     4021 ataaagtttc tattgtaaat cataattatc tagaagaatt agcaatcggg gtcaatgaaa
     4081 ttgttgaaca attaaaagtc tccattgatg aagaaagaca agcggaacaa gcaaaaagtg
     4141 aacttattac aaatgtatca catgacttac gtactcccct tacttctata gttggatacg
     4201 taaatttaat ccatcatgat aattatagag atgaagtaga attgcgatac tatattcaag
     4261 tcatttacga taaagtaact cgtcttaatg cattaatgaa tgacttgttc gaatatacac
     4321 gtgttcaaaa taaagagtta agcttgtatt ctgtccctat tgacatagta gagttacttg
     4381 ggcaattaac tgttcaattc cgtatacaat ttcaagaagc aaatatagaa tgtcgacctt
     4441 ctttcccatc tcaaaagctc atggtattag ctgatggtga aaaattagtg cgtgtgtttg
     4501 aaaatcttat tataaacgct atcgcttatg gaagcgaagg tcgctatatt gaccttactg
     4561 cttatgaaag caataatatg attacaattg atataacaaa ttacggacaa cctattccta
     4621 gtacggattt acctcatatt tttgaacgtt tttatcgcgt tgagaaatct cgctctacaa
     4681 acactggtgg atctggactt ggattagcta ttgcaaaaag tatagtcgaa ttgcataaag
     4741 gaacaattga agtatatagt gatgatgaaa aaacaacatt cactgtaaaa ctactcccat
     4801 acaaatgtta atattataaa taaaaagttc aatttcttat catacaagaa attgaacttt
     4861 ttccattaac acccaaaatt taatgatcct ttataattct ttagaaattc tttacctttt
     4921 ctttcttcct aattaagcat tcctttttac aatactagta ttgatgtcat aataggagga
     4981 tcgcttatgc aattcttaaa gaaattcgct attttattat tatctttttt tattactgca
     5041 cttatcgttt tatattttta tctttatgta aatggtccca ttattcaagc taaatcagct
     5101 attttaataa atgctaattc aggtgaaatt gtttataaaa aaaatgaaga aactccagta
     5161 caatcagctg ctttatctaa attaatgaca gaatatatcg tattggagca actaaatgat
     5221 agaaaaatac agttagatga cttcgtacaa ataagtaacg aagttttccg agtagaaaca
     5281 agtcctatac aagtaacatc gaatgataaa acaacggttc gtgatttact tcatgcattg
     5341 ctactggcag ggaataatcg ttctgcactc gctctagcag aacacattgc tggaaatgaa
     5401 gataacttta caatattaat gaataaaaaa gcaaaagaac taaagttatt acaaccatct
     5461 ccatttctaa actctactgg aattaataat gatacaaata aacaatcaac tacaacagca
     5521 atagatgcag ctaaactagc agcacgatta gtaaaagatt ttccagatgt attgaatatt
     5581 acaaaactaa cctcttacca atttaccttc aaagattccc aggttttcaa tacgaataaa
     5641 atgatatatt cccttaatga aaacattaaa cttcaaggtg ttgatggctt acaaactagt
     5701 ttttcaacta acggtaatta tagttttgtc agtacagcaa aactaggaga cactagacta
     5761 atttcagtaa tattagatgc agatgaagaa aacatttcat ttattgaaac aaaaaagtta
     5821 ctacagtatg gttttgatcc ttcctcgtgc tctgcactcc aagcgtttaa agatgctgtt
     5881 acatcttggg cagttttgct tcagtttaaa aatttgatca tacaaacatt attggttttc
     5941 tttataatta caattttaat gtttttacat atacgtcaaa aaaaatccga agatttcaat
     6001 taagaaatct tcttatatat aaaaaccgac ttgcgtttga gatgcaagtc ggtttttaat
     6061 tctatcatcc tcgtccaatc aaatttgctg aaacaaattg ctagtttaac tccctcgccc
     6121 atatagatag ctgaccaata tgatgaattt catatcccat tacatgtctt aaaacctatg
     6181 ttttttgagg catacatcca tctctgtttc ctttcgttgt attcgtttgt ttagtttaaa
     6241 tgggttaatc tattaattct attaaatcca acaattgaac tattacattt taaagttcca
     6301 ttcatatact atagtagatt actagaaagg aggcttaact atggatagtt gcgttgtatt
     6361 tgtaaacgga caaccttttt tagttctttc agtagctggt attgaaattg ctagattaga
     6421 gatttccctt caagtagcat tagctctaag agtgcttggg ataccaatct gtgattaatt
     6481 accaaattaa aagaaaaaga gggcattagc cctctttttt tattttcttc tcaccttttc
     6541 ttaacaacaa acaaaattca aattttaatt tttatattgt aatgaaaatc cgaaaaatca
     6601 acccattcta ttcaataaaa aagagcacca cccatacctc tttatccgtt tctataatat
     6661 tcaaatttga ttaattataa aaaattaaag tatatgaacg ttacatgaag cacttgttaa
     6721 gatagctgtc cttcacacta tttatttcgc cgacattata taatcaaagc acacaataat
     6781 taacttttta tactgcttat tttaagtacg ctagcattct aggctagatg atcatgactg
     6841 caaaaaacct tcaagttctc gtttatataa atcagataac gctttcactt tttgaatcga
     6901 atgataatct ttaaattgcg gttctttatc ttcttctcct tgaagagcac taatccaact
     6961 atactctaca tctacaatat gaattaatgt ttctaaaata ccaccagttt gcaaagtaaa
     7021 tcttcctctg aaagttgttc acacctctta aaccactcat ctcttacttg ccaattatat
     7081 tgaaataaag tatacacatt tatctctccc ttacttcaat tatccaccta acagcatctg
     7141 ttatacattt aaccattgac aatcacttct cttcggccaa gttcctctac agcgtgatta
     7201 attatttcac ttacagataa agaaccatcc aatatgatat ctgaattcgg cttaacagta
     7261 tgaattgctt ctaaataagc ttttctcgca tatgtcatat aatgttccaa atcattatgt
     7321 atttcatcta ttgtaccttc cttaaaatct cgcaaaatcc ttctagccat cgcaatatct
     7381 aaaggcgtat caataaatat agttacatca atgaattttc gcatctcact atttaagtat
     7441 gcaaaaggat aatctataat aatatagtct aagctattat tttgtataag ttgctcaata
     7501 tcatgaatta atggtgttaa tacccactcg tcataattcg ccccatcatc aatccattta
     7561 caaatatcag caggacagtt atcaaatgta taactatcaa aatatagagc ttttgagttc
     7621 ttaaactcat gctttaacct ttctgtaatt gtagttttac ctccccctga aacagctgca
     7681 actgaaataa tttttgtttt attatccact atatccacca atcccctttt gttaacataa
     7741 tataattata aatcactatt gttactactt cttccattca tattctaaca tactcatttc
     7801 ccataaattc caatacgttt cccctacttt tttcgactct cttaataatc cttcttttac
     7861 aaatcctatt ttttcgtaac atgaaatagc cgacgtatta aaatcataaa caccaagagt
     7921 tactctatgt agttttaatt tgtcaaaagc aatatgaagt actgctttca tcatatgttt
     7981 tcctatagaa cgtcctctca tcttcgtatt accaactaat acttttccaa ttctagcgga
     8041 cttgttaata ttatctattt gcccaagcga aatatgacca ataacgtctg aagtctcttc
     8101 atctaccact ttgaaagcga atgtatttgc actttctata tacttctcta attgctgttc
     8161 gtctaaagga aatgtgaagg cattacctga ccattgtatt agaaattctt cggaattaat
     8221 ccaatttatt aattgtttaa aatcagattt tttaaaggtt tctagtttaa tcacttcctt
     8281 gctcctttcg tacatcatgc tttataacct caaacttatt tctatataaa gaatatattc
     8341 tccttttata tgaaattaaa ataaagccat tcatgtgaat ggctttacaa aaaagcaaca
     8401 taattatgct ttgtttgcta catcaatacc attaaaatca aagtcagcag taaccgttgt
     8461 aataggtggg aaaattgctt caattttgca aatggaaata attactgcaa ccgatccagg
     8521 aatagccgca agcctaacta catcacaact tacagacgag acagtaccta cataagtacg
     8581 tccctctgta ttaatttgaa ctgttcgatt aattaatttc ttaagttcat ctctaattcc
     8641 ttgtacacaa gaattatcac atttctcatg ctgttctttt ttacactctt cgaatacttc
     8701 ccaacaatca tcttgtttac atgtacattt ctttttacaa ttattaaatc gagaacccaa
     8761 tacctcacct cctaatcctt tctattagta aagtatgtcc attagcttaa aagggtacga
     8821 ggcaaacaca taaaaagaaa aaaacaaaca attgtaccaa actttctttt cattattcat
     8881 tataaaaaca gacctgccct aattaaaagc ttgtttaatt agggcaggtg agtttagtcc
     8941 tacttcattt aatgtttaga caccactttt taaaataaat cttttttctt ttaaataaga
     9001 cgcctcttaa aaacacacta gattttccca ttaactcata tatacataga ctttattcat
     9061 ggttttttcc tttgttatcg taaaatatac attttaaaaa acgtactcga aaataagata
     9121 ttatttgtaa tcagaacatt ttcttcaaca aatgtttatt gaaaaatacc ataactagta
     9181 gtagttccct ccactatctc ttaaaaatta gcatagtttg tatgaactct ataccgagta
     9241 gaaaacactc tatcatataa aaataaaata gtaggttaat aaacaagcca tttttttatt
     9301 aaaacataga ataatatgaa cactattgaa aggaggtaga aatgaatgtc ctggaaaaat
     9361 gattgctgga gttctcagaa aaagcattgt tgtgatgatt ggtggaaatc taaagaaaag
     9421 cgtcattgtg atgatgattg gagttctcag aaaaagcatt gtaatgatga ttggtggaaa
     9481 tctaaagaaa agtgtcattg tgatgacgat tggagttcta aacgaaataa gtgtcgttgt
     9541 aaatgtttct ttatttgttg ccattgtaaa agaaaaaatt ggtaatattt ttaatgtcaa
     9601 cgtaaaggaa agaatatgtc ttttggaacc aatcgggctt ttccggaaag ttgatccctc
     9661 acctacttcc ttgcttttgc tgaattttta gatgggggca ttactgcccg gcaaatacta
     9721 gaatgtaata tataaaaagc tgactgctta tagtcagctt tttatatatt aacacgtaaa
     9781 ggtttaaaca gacatataag cagtcacgct ttgtcatcac cttgttgttg taaattagta
     9841 tttctacatt gaatagacat tccataatat cgtattttga ttaaaactaa aaaacatact
     9901 taacactaat agtaaaattt ttcttcttca tcaacttcac ttcttctctt tttataaaca
     9961 taaaaaagga gctctattta tatagagatc ctttctaatt ttataattta ctagactgta
    10021 aaccctgaat aaacggaact acttcaggat ttacaagcga tgataaatca cctaattctt
    10081 ttcctaagta agctgcttta ataacacggc gcattacttt agaattacgt gttttcggta
    10141 aatcttctac aacgtggatg tctttaggac acaacgcttt tccaatatga gagtttacta
    10201 aactcattaa ttctttcttt aattcccctg tgaatgttac atggtctctt aacactacaa
    10261 aacaatgaca aacttcacct tttacttcgt caggtacacc aattgcagca gcttcgatta
    10321 catcgttatg tttcacaaga atagattcat attcagcagg tccaatacgt ttacctgcaa
    10381 tatttaacgt atcgtctgaa cgccctgtga tgatatattg ttcaccatcg taaatgaccc
    10441 agtcaccgtg gacccattta ttttcaaaac gcgaccaata tgtgtttacg taacgttcat
    10501 catcttccca gaagcttttc gtcataccta cccaaggttt ctctaagcat aattctccga
    10561 cttcatctcg aattggttta ccttgatcat ccagtacgac agctgccatt cctggtaaag
    10621 atgcgttaaa actaatcggt gctattggct taataagaac attaccgaaa atcccaccag
    10681 agatttcagt tccacctgag tagttacaga ttgggacatt tccttttcca actgtttcaa
    10741 acagccacat ccatggatca ggattccaag gttctcctgt tgatgcgaat acttccaaac
    10801 tctttaaaga atgtttattg acatactcat caccttttgc catcaatgct cggattaacg
    10861 ttggcgaaat acctagatga gtaatctcat atttatcaac tgtctcccat aaccggtctg
    10921 cttctgggaa gtctggaaca ccttcgtaca taaccatcgt tgctccatta atgagtgaac
    10981 cgaataatag aaacggcccc atcatccagc ccatatcagt tacccataat acacgatcac
    11041 cttgtttaat attcattcca aatcctgcat caaaagctgc tttcaaagga aatcctgcat
    11101 gcgtgtgtac tgttcctttc ggcttaccag tcgttcctga tgtataaatg agcattaatg
    11161 gatcatcact ttgcatttcc tcggcatgta tgaatggttt ttctttttct agcgtactcc
    11221 acgaaaaatc atagttatgt ggtgtaaaat catttcctgc atgacgaacg ataacaactt
    11281 tttcaacagt tgggcaatgt tcacaagctt tatctacttc atcttttaaa gaaacaattt
    11341 taccgcggcg tgaaaatcca tctgcggtaa taatcatttt tgaacctgcc gcttgcacac
    11401 gtgtcatgac tgcatcagac gcaaagcctg agaatattgg tgaaataatt gctccgattt
    11461 tcattacagc tagcatcgca acaactgttt ctggaatcat cggcatataa attgttacac
    11521 gatcaccttt ctcaataccc gcatgtttca aaccatttgc aacacggctt acccagttgt
    11581 caagctcttc atatgtaaat gattttgaag ttccattttc cccttcgtac tgaagtgctg
    11641 gctgtattct cgtctcttca tccgcaagcc agcgagataa agctgattct acaacgttac
    11701 atgttccgtc attataccac tgtgcaaacg gtgtaccatt ttctaagtct aacacttctg
    11761 tataaggttt catccattga tagcctactg ctttttctgc ctctccccaa aaccaagctg
    11821 tttcctcaat agatttatta taaaaagttt catagtcttc atatcccaat gatttcatcc
    11881 aaccatataa acgtgttttt tccttgtact cttctgttgg aaaccaaact gcttgtttca
    11941 atgttttccc ctccttaact ttttgagcaa gaaagcccta aatagggctt ttaaactgga
    12001 tatacaggat gtttacgatc tgtgaatact tgatatttac tcatatacat ttcgaaacgt
    12061 ccttttaact cttcacgtaa attgtttgga tgaacaatac catcaatcac catctctgat
    12121 gctaaatgat aaatatcaat atctttctta tactcttcac gtttttcagc aatgaagcta
    12181 gcacgctctt cttctggtaa agctgcaatt ttatttgcat atacagcatt aaccgcagct
    12241 tctggaccca ttaccgcaat agaggctgtc ggtaatgcca gacagcaatc tggttcaaat
    12301 gctggacctg ccatcgcata taaaccagcg ccatatgctt tacgaacaac gatagaaatc
    12361 ttcggtacag ttgcttcact cattgcagaa atcatttttg caccgtggcg aataataccg
    12421 gcacgctcta cttttgtacc aatcataaat cctggtacat ccgcaaggaa taataatgga
    12481 atatgatatg catcgcataa attaataaac ttagcagctt tatcagctga atcgtggaat
    12541 aatacgccgc ccttcatacg cggctgattt gcaataatac caactggctt accatcaata
    12601 cgtgctaagc ctgtaattag ctcttgagca aataattttt tcacttcata gaatgaacct
    12661 tcatcaataa ctctattaat gagatctttc atattgaaag gagcattttg attttctgga
    12721 atgatttgtt ctaacgtttt atcgaattgt ttcggttctt gaggtgtaac caatggagtc
    12781 ttttctaagt agttgtttgg aaaatatgaa atgtattgtc ttgcttgtgt aatcgcatct
    12841 tcttctgtct tacataaaac atctccgcat cctgatacag agcaatgcat acgagctccg
    12901 cccatctctt ctaaagttac cttctcaccg ataaccatct cagccatacg aggagatcct
    12961 aaatacatag atgcatttcc ttctaccatc attacaacgt cgcaaaaggc tggaatatag
    13021 gcaccaccag ctgcagaagg tccaaataat aagcatactt gaggaacttt acctgataat
    13081 ttcacttgat tatagaagat tcttcctgca ccacggcgcc ctgggaacat ttctacttga
    13141 tctgtaatac gtgctccagc agagtcaact aaataaaata acggaacacg tagtttttca
    13201 gctgtttctt gaatacgtaa aatcttttca actgtgcgtg atccccatga tccagctttt
    13261 acagtagaat cattggccat tacacacgca gtacgaccat gtattttacc cgttgccgtt
    13321 acaacgccgt ccgcaggtaa gcctgtttgt tcacagttag caaataatgc atcttctaca
    13381 tattcgccat tatcaaatag aagcgctaaa cgatctcgaa caaataattt tccttttgct
    13441 ttattttgtt catgatactt tggtgcgccg ccttgtttaa tcgtttcaac tcgttcttca
    13501 aatgaattag attgttgttt ttgatctaac atatttactc ccccttatac gttggtgtgc
    13561 gtttttcctt gaatgcttgt aatccttcta atctatcttt cgtgtggatt acaccttcat
    13621 acgcttgttt ttccatttgt aatccggtat gtaaatcaac ttgaatacca tttgaaattg
    13681 cttcttttgc taatcgaaca gcaataggtc cattactagc aattttctct gctatttcaa
    13741 tcgctttctc ttcaagtaaa ttagctggta caacaaattc tactaaacca tattcttttg
    13801 cttcttgcgc tgaaatacgt ctacctgtat aaattaattc tttcgctcta ccaactccaa
    13861 ttaatcttgg taagcgctgt gtaccacctg ctcctggtat aattgcaagt gtcgtttcag
    13921 taagaccaag acttgcagat tcagcagcaa ttctaaaatc acaagctaaa cttaattccg
    13981 taccaccacc aagtgcgatt ccatttatag cagcaataac tggctgtggt aattgttcaa
    14041 ccatctccat agtagtgcga atcatactaa cagcatgacg aacttgttct tcattcatat
    14101 cggcacgctc ttttaaatct gcaccagcac aaaatgcttt ttcaccagca ccagtcaaaa
    14161 taactacacg tgcgcttgaa tcttcactta tttgagttaa tatagtttgt aattcatcta
    14221 ataatgccaa agataatgag tttgcttgtc tcgcacgatt taacgaaatc tttactacgt
    14281 gaggtgttac gtaatcaacg gaaatgtttt gtaattgtag catctactca cctacttatc
    14341 gttttatgtt gaagcgctct atacacatga ctcggtaatt ggatatttaa cttactttga
    14401 ataaattgac tagctctcaa taacttttct tcgtctatat tcgtttggac tcctaattta
    14461 tggagcatat gtactaggtc atcagtagca acattacctg atgctcctgg tgcataaggg
    14521 cagcccccga gtccaccaca agaactatca aacgttgtaa taccgtattc taatgattta
    14581 actacattcg ctagagccat tccatacgta ttatgaaaat gcattgcaaa ctgcgaagca
    14641 tcatacttct ttaataggtg ttctaatact tgttctactt gtaatggatt cgctacaccg
    14701 attgtatccc caagagaaac ttcataaatg ccgtatgaaa atagttgatt acataattcg
    14761 tcaactgctg tagcacttat atccccttca taaggacatc caaatacagt agaaacatag
    14821 cctcttacct ttttcccttc gaataatgcc tgttttgtta tatcttcaat tacaactaat
    14881 gcttctttaa tcgatttatt aatattactt ttattatgag attcacttgc tgataaaaaa
    14941 acattcacct catctacatt ttgcaaaaaa gctcgttcca aaccattttg attcggaaca
    15001 agcgcagcat atgtaacatt tggatccctt ttcagctcag aaaatacatc atttgcatct
    15061 gctaatgcag ggacccattt tgggtgaacg aatgaggaaa cttcaacata cgacaatcct
    15121 gcttctgtaa gtagttgaat ccattttact ttatcttttg tgccaacaat ctttttttca
    15181 ttttgtaagc catcacgtgg cccgacttct ttaatgacag caaaattagg tagtttcaat
    15241 tcgcttcccc ctatatctcc ctattcaatt tctaataata catctccttc atttacaaaa
    15301 tcgccttctt gcacattaat tttcataact gtgccggctt cttctgaaat gattggaatt
    15361 tccattttca tagattccaa aatgacgaca tcctgctctt cctctactgt atctcctact
    15421 cctacaacaa tcttccaaac gtttcctgcc atcgatgcgt atactttcgt catcattttt
    15481 tcccccttaa tattgttaaa tcttattttt taacgagttg tttcgttaca aaacccgttg
    15541 tataaatacc ctctttgaac acttcgtctt ccaaaacttg cagtagcatt ggcgtgttcg
    15601 ttttaatacc ttctactttt aattcttcta gagcatcatg taatttcgaa attgcttctt
    15661 cacgagtctc gccatgtgca atgactttcg caatcattgg atcatagaaa ggtgtaatcg
    15721 ttacatgatt ttctaagaag tgatcgatcc gtacatttga cggtaatgtt aaatttgtaa
    15781 ttttcccagg tgatgggaag aatgttttcg gatcttctgc ataaatacga gcttcaatgg
    15841 catgaccact acgttttaca tcatcctgag taaatgatag tttctctcca cttgcgataa
    15901 gaagttgctg ttctacaagg tctaatcccg taatttcttc tgtcactgga tgctctactt
    15961 gtaatctcgt attcatctct aagaaataga agttcttctg atcatctaca agaaactcaa
    16021 ctgtacctgc atttgtatag ccaagtgctt tggcagcttg tacagcaact tctcccattg
    16081 cctttcgtgt accttcatct aaaaatggtg aaggtgcttc ttcgattact ttttgatttc
    16141 ggcgctgcac cgaacattca cgctcccata aatacactgt gttaccatgt gtatctgcta
    16201 aaagctgaat ttcaatatga tgcgcgtctg ctatatatcg ctctaaatac atttctccgt
    16261 taccaaaaaa gttttgcgct cttgttttat tactttcaaa cgctttggtg agcgtttgct
    16321 cagtttccat caactgcata ccaatgcctc cgccgcctgc ggatgcctta agcattaatg
    16381 gataaccaat ttgttttgca atttcaattg cttcttcagc agtttcaata tttgtagtaa
    16441 tacctgggac tactgggaca tctgctgctt gcattgcgat acgtgattcg attttacttc
    16501 ccatcttcgt aatgatttct tctgaaggac cgataaatac gattccttct tctttgcaac
    16561 gaaccggaaa agacggattc tctgataata aaccataacc cggatgaatc gcttctgcat
    16621 ttgtcttctt agctatttca ataatttttt caaggtttaa ataactttct tgaacacgcg
    16681 gtccacctac taagtaagct tcatttgcca tcttcacatg aagggcattt tcatctgctt
    16741 cagaataaat agcaacagtg cgtatgccaa gtttttgaca agttttcata atacgaacag
    16801 caatttcccc gcgattcgca attaatattt tttgaaacat agtgattcct cccttttatc
    16861 tacatcctaa atgtctagca attacgagac gttgaatttc agaagttcct tcaccaattt
    16921 ctaatagttt cgcatcacga atatgtcgtt caatttcata ttcacgcata taaccatatc
    16981 caccatgaat ctgtactgct tgattcgcaa tacggcttgc tgcttccgat gcaaatagtt
    17041 ttgccattgc cgcttctttg ccgaaaggtt tatcgttatc ttttaaccaa gctgctttat
    17101 gtactaaatt gcgtgctagc tctacttcag tcgccatatc agctaattta aattgaatcg
    17161 cttggaaatt agagattgac tttccaaatt gttgacgttc tttcgcatat tgcaatgcac
    17221 gttcaaaggc tgattgcgca ataccaactg ccaatgctgc gattgaaata cgccctccat
    17281 caagtgtata taaaaattgt ttaaaacctt tatttacatc accaagaata ttttctttcg
    17341 gtacacgcac accatcaagt acgatttcac aagtattaga agcacgaaca cccatcttat
    17401 cgtatggact tgaaatcgtt aatccttcac tagtagtagg cacgataaat gcagaaatac
    17461 gttttctacc attctcttca atgccgttga cagcggttac aataattgtg tttgcatact
    17521 ctgcgtttgt aatccaacac ttctcaccac tgattacata ctcatcgtca tctaataccg
    17581 ctttcgtttg agtgccacct gcatcagatc cagcattcgg ctccgttaat ccgaaggcac
    17641 ctaatgtttt acctgacgcc attggaacta aatacttttg tttttgttct tctgtaccga
    17701 aataataaat tggagaagca cctaatgaaa ttgttgcagc atagcttaaa ccagtgccac
    17761 cacaagcgcg accaatttct tcaactgcta acgcatacga tactgtatcg ccacctgaac
    17821 ctccatactc ttctgggaat gggatgccta ataatcctag ttcgcccatt ttttgaaatg
    17881 tttcatatgg aaactctgca gttttgtcat aatatacagc tttcggtgcg atttcctttt
    17941 cagcaaagtc acgtaccatt tctttaatca tttgtttttc gcgagttaga gtaaattcca
    18001 ttccgctaca caccccttat cgaatattga gtttcgacag cgtgcgagtt tctactacaa
    18061 acataacaac ttaaaagaca agaacattag ttagacaatt gctataattc tgtcataact
    18121 taattttaaa acagattctg tactaatgca caaaaaaatt cctacattgt tctacaacaa
    18181 cataggaagt tttgtgtcga attatgtaat ttattgttta ataatctcta ccttttcccg
    18241 aatcagaaat ttctactaag gcttcagggt atggttcgaa atacgtttgt cttaataaat
    18301 acttttcatc aaatcgaatg gcccatgatt ttaaaattgt aagtaaacta ctaagcggta
    18361 ttttcttttc tgcatacttt tgtaacagtt ctataaaatg atctttttct tgttttttta
    18421 gctttgtttt aaaatatcca aaaatgtgct cgcatacatt tacattcgat gtataacggg
    18481 gtgtgcgcat aaataattca tataaagtct tctcatagtt ttcaaatacc acttcaatct
    18541 tttcattttt gtgatttgca attatacgcc ctaattcctt ttgtttcacc tgattatatg
    18601 ccataaataa atatttatta tccgactgaa acgatacaag gtctttcata tttttattat
    18661 gtttaatcat tttgtaatat gcgattgtaa atagccttgt aaagaaatgc tctctaataa
    18721 taaaattcga caatctacct tcctcttcaa taggaagatg cgaaaatttt tttactactg
    18781 ctccgccaaa taagccagct ccttttccct ttgctggcgc tttttcaaaa ccagaataaa
    18841 ttttcacatc acgcgtacca caacttggtg aacgattctt taaaataaaa ccatccacat
    18901 ccgatatcgt ttgtaaaaag tcatttgaaa actgctccat ttttccagtt acatcttctc
    18961 gtgtcgacgg ttgcacaagt ctattctcac cattttcttc tacaattcgt atcgtttcac
    19021 gaggagtccc caatccaatc tcgacttctg gacaaacagg tataaatgta acaaatggct
    19081 gcaaatttcg tattgttaca tctggaatca tctctccatt atatcgacag gcatcaaatt
    19141 ctaaacattt acttacaacg attgttggtt ttgcaaattg tcgcatctca ttacctcctt
    19201 agtgctagtc cgtatactat aaattgtact aagattaaca ttttaagcaa agtttgattc
    19261 atttattttt atgagaaata tatatccaat gatatattaa caatcattca actctatttt
    19321 caataaatgt gcgccctttt atactggttt agatattgtg aaatgaataa tacacagatg
    19381 ctccggagaa attaatgatt aagaaaggag ggaattgtta tgaaaaagaa attatcatct
    19441 attttaagtg ttttagcact ctctattatg tttttaggta catctgcgca agctgaatac
    19501 gatggaaata atatgaatag agtgaataac actgatattt caactcgagt aaatgacaat
    19561 aatttagaca gagttaataa tgatgtaaga actcgaaatg taaatacaac aaatgattta
    19621 aatgataatc gtgatagaaa taataattgg gcttggcttg gtttattagg actagcagga
    19681 ttattaggtc ttagaagaag agacaaagaa acacgctgat ttagaatgtt tttagtaaac
    19741 aagtacttat ttatcaaaaa tatataacga aaataaatcg cctttttaaa ggcgatttat
    19801 ttttacttaa aaagtaatgt atgtaattca cacttcgacg attaaattcg tggagttaat
    19861 ccatacaata taaattgaat cgtattttca atttctgctt catcattcca tttttcttca
    19921 ggcaataata aaaatcgtgt taataataaa cctaatacag ctgataaagt aagacgtagt
    19981 acggaagatg gtggtatctc aataatttcc ccttcttctt gaaatttcac aatcaacttt
    20041 ttgaaatgtg aaaacagttc tgtttctact aattgttgta tttcattttt cagttctggt
    20101 tggaatggta cttcttgaat taatattttt atcataggaa agtgtttttg agcaaattta
    20161 aatctattat gaattacaac ccttaaaagt ccttcgtacg attcatactc cgatttaaat
    20221 atttcttttg caaaggtttg tacgaaaaat ggtgcagcga acttagttaa agttggcatt
    20281 acgaccgcta gtaataaatc ttttttcgtc ttatagtagc ggaagattgt tccttccgct
    20341 acaccagccc gttttgcaat ttcacttgtt gaagttgaag cgtatccttt ttctccaaac
    20401 atatcaacag ccgcctctaa tattcgcatt tgacgttcat ttcgtttatc cgtattagtt
    20461 gcagctatta attcctccag ccaatccttc tgcatttata aagctccttt ttgtcattat
    20521 tatattttgc gatgtttctt taaagcaaat acatttccta ctgcaaataa tattgaaaaa
    20581 agtaataata cagtaagatc taatgcaatc tctgtaaacc cttgattccg aatcatcact
    20641 tgtctcattg cgtcagcgcc gtatgtgagt ggaaatactt ttcctaacat ttgtagccac
    20701 ttattcatag attccattgg aaacaatcca gaaaagaaga tttgtggcac aataacaagc
    20761 ggtataaatt gaatcatttg aaattcatta tttgcgtatg ccgataaaaa cgtacctaat
    20821 gttagtgcag ttaaagagag catacatgta ataagtagcg ttagccatat ggatccagct
    20881 acgtataaat ctaaaatata aacggaaaaa cttacgataa taatggattg tataaaggca
    20941 aagattccaa aaccaataat ataacctgcg actatttccc atcttcttac tggggtggat
    21001 aataaccttt ctagcgtacc acttaaacgt tctcttacga aagatacacc tgataatata
    21061 aatacaaaga aaaatgtaaa gaaaccaatt aatacaggac caagcccatc aaacatcgta
    21121 aagtctttag agccatgtaa ataatttact tcaggtttca taattgatac ttcattgttc
    21181 tctatgcttt tttgcaatac ttgaagtaca gcacgatttt ttgacgaatc actaccttcc
    21241 aacagaagtt tcatttttcc attctctatt cgaagtactg catctaccgt ttgtttttcc
    21301 aactcagaaa tcgccttttc tttactgtat tcataaattg atgcttcttg atctttcatc
    21361 acttttacta tttgagcggg catatcaaca acagcaattt gaggtatata gtctttctgt
    21421 gtaaacacta gcgataatag ccacagtaat aacatcggtg ccccaaacat catcgctaac
    21481 gaacgcttat ctcgaaaaaa ttggcgaata atacgaatga ttacaccagt aactctcatg
    21541 atggcaccac ctcttctagc aaaaagacat cttcaatccg tccagatgac acgcgttttt
    21601 tcaattcttc agttgttcca accgcaacta gcttcccttc tctaattaat cctagacgct
    21661 cacaaaattc agcttcatcc ataatgtgcg tcgttacaat aatcgttgtg cctttctttt
    21721 taaggtcata aaatttttcc caaatcgttt ttctaagaag cggatctatc cccactgtag
    21781 gctcatctaa aattaatatt tctggttcat ggaggagtgc tattgctaat gataaacgtt
    21841 ttttcattcc acctgaaaat tgttgtactt gctttttcat atactgtgat aattgtacaa
    21901 gttcaaaaac ctctgcaatt cttttctttt tacgttttcc ctttagtcca tacatcgttg
    21961 ctataaaatc tgcattttca tatgctgaca attcttcgta taatgcatcc gcctgggcca
    22021 tataaccaat tcttttcatt tcatttaaat taggcatatt agtattatta acaagcactt
    22081 cacctttcgt tgcctcatta atacctgcaa tcattttaat gagcgttgtt ttccccgatc
    22141 cagaaggtcc aacaaaacca aaaatctctg ctttttcaac ttgcaatgaa agattgtgta
    22201 acacttcttt ttttccaaaa ctttttgata cagtccgtaa aataatggaa agttgttgca
    22261 cgtttcatcc tcctttttca ataaaatgag tgagtactca cttttatttt acccttgctt
    22321 aattatatgt caaacttcat tgattagtat gtatgttcaa tcaacgatat gaaacaatga
    22381 aacagagtcg acattagcat ttcatttcct aaagtcgact ctgtttcatt taaactataa
    22441 atttcacttt acgtttttaa attcatatac ttccgaattc tagcaacatc taaagaatat
    22501 tcaataacta attgctgtaa cggtaaaata actgtgtcag gatataaatg tgcatattgt
    22561 aatgtttctg catatttttc taaccttttt tctaaatact ttattatttg atcaggatga
    22621 cttactaata aacatttaca ataataatgt atttgttcct caatcgccgt gtattcttca
    22681 atttcatatt ctttatgcat gtgtacaccc ctttaagttt tttacatgaa ttacttatca
    22741 caattttcac tcgacaaatt ttaagttttt tgattattta cactataaca aacactcagg
    22801 gtcaaatttt gttactttat gtaacgtaga aaatttttaa caaaattgta atgttaactc
    22861 ctgcaaaata cataaaacac ctttactcat tattgtataa aaaaatcgta caacttaatt
    22921 tagctgcacg actacaattt ctggcctgtt caaaattctt tgcggaatga tactatttcc
    22981 taatcctcta ctcactacca ttgatgtatt ttgttctata tataaacccg ctgtatattt
    23041 aggtaaaaca ccttgatttg gcgcgactaa tcctccgata aatggcaatc taacttgccc
    23101 tccatgagca tgtcccgata aaaccaaatc caatctctca ttcgtatatt cctttataaa
    23161 ttcaggccta tgggataata atacattata tctatctggc tgcatttcaa ttttcgtttt
    23221 tttaatttca tctattataa tatttccttc atcaccgttt ccagtaacaa actctggatc
    23281 atcaatacct agcaagttta tttcttgctc accctttcga atgcccacat gttcattcct
    23341 taaaacattg acatcatatt tcttcaactc tttttctaaa ttgttatact ttccagacca
    23401 ttgttcatgg tttcctgtca caaaatatac aggatacttc tttacaattt ctcgtattaa
    23461 ttgcatacta acttctgcat catatgattt actgtcaatt aaatcaccag taatcgcaat
    23521 aatatctgga tctatgcttt taattttttg aattaacaca tcttgattat cgccaaattg
    23581 tttattgtgt aagtctgaaa tttgtagaat tttataccct ttaaaagagg agggtatttt
    23641 actagaggtt attttaacct cagttatact tattaaattg ttctgtaaat ataaaaagat
    23701 tgtaaaacct actactatac aaataatcat tacgattcta ttaatctttt ttttcatatt
    23761 ttctccttta tattctcatc aaacacttct atatgctaac tgaattatat tatactttct
    23821 tgaaatttgt ttaaattaat aaaataatac agtacataga atttcatatg agatacgtca
    23881 tatatattcg ttatattttt acttttacct ttttaataat aagaacacaa aaacgactct
    23941 tatcacacga aaagagtcgt tttctaactt tatactttta atacttttat gttaaaaatg
    24001 cgaaaactaa aatactatta cctaagagcc ttaactataa cttcagttgc ctctgcaatg
    24061 agttgattat cataggtagc ctctttctca tctttactag ataaaattgc gatgataact
    24121 ggtgctctat ttggaggcca aacgatagca atatcatttc ttgtcccgta actgccagca
    24181 cctgatttat ctccaactac ccagtcagtt ggtacgcctg cacgaataag tttgtcccct
    24241 gtagcatttc ctttcatcca ctctgtaaga atgttacgtt tttcagctgg aagtgcattt
    24301 ccgaccgtaa aagctttaag attcgtagca attgctttcg ctgtactagt gtcacgaatg
    24361 tctcctggaa tagcttcgtt taattctgtt tcaaagcgat cagacatagt aatccgatcc
    24421 cccatctgcc taagcgcttt ttcatatcct ttaggtccgc ctattttatt aaataaaatg
    24481 ttccctgcag tattatcact tgaacgaaca gcagcctcag caatttctcc tagtttcatt
    24541 ccagtatcta catgtttctc tgtaacaggt gaataatcca ctaagtcttc tttcgtaaat
    24601 gtaatcactt catttaatgt atcaattgag ttttgctgta gtaatactcc tgccgctaaa
    24661 gccttgtagg ttgatgcgaa ggcaaatctt tcattagatc gataagagat tgtttgattt
    24721 gtaccagtat caatcgcata tacacctaat cgagcatcaa atttcttctc aagttgagag
    24781 aactctttat gcgtcgcctg atttttatgt ttcacatgtc cagtcttttc tttcgcttca
    24841 acttgcagtg cccctcctgt aaaagcttct aggcttgtaa gacttaaacc taatatacca
    24901 acgcatattc ctatttttag catcctctta tttttcaaaa ccatcattcc ttccaaattt
    24961 ttagcacctt tttatacgta cacataatag acaatcatcg aaccaaactt gttccataaa
    25021 ctgaaaaaat ttatagctag tatgagagtt attaacaaaa taagagatag tagctatgat
    25081 cgccgctatc tcttatttca catttcattt ttttacttat aaatggcttt atatgaacag
    25141 ggtctcttcc ctgagaaaag tactctaatt ttgcttagag ctacttgtac tagtagcttc
    25201 accatgtata cgttgctgtt ttaaatcaaa gtatacatc
//
