Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
4.1
4.2
4.3

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_KB976300.1 (Bacillus cereus K-5975c)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 1,315,781 | 1,336,671 |  |
Region 1.2 | terpene | 2,012,389 | 2,034,242 | Low | molybdenum cofactor | other:other
Region 1.3 | NRPS | 2,817,423 | 2,864,439 |
Region 1.4 | RiPP-like | 2,882,837 | 2,893,097 |
Region 1.5 | RiPP-like | 2,991,338 | 3,001,667 |
Region 1.6 | betalactone | 3,052,726 | 3,077,964 | Low | fengycin | NRPS:Type I
Region 1.7 | NRPS | 3,123,457 | 3,189,365 |
Region 1.8 | NRP-metallophore,NRPS | 3,279,673 | 3,331,421 | High | bacillibactin | NRPS:Type I
Region 1.9 | NI-siderophore | 3,614,931 | 3,646,638 | High | petrobactin | other:other
Region 1.10 | azole-containing-RiPP | 4,243,075 | 4,266,581 |
Region 1.11 | NRPS,RRE-containing | 4,555,010 | 4,598,314 |  |
Region 1.12 | NRPS-like | 5,054,233 | 5,097,814 |

NZ_KB976303.1 (Bacillus cereus K-5975c)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 1 | 15,015 |
Region 4.2 | lanthipeptide-class-ii | 364,622 | 387,810 |  |
Region 4.3 | NRPS,T1PKS,NRPS-like,lanthipeptide-class-ii | 406,039 | 515,563 | High | zwittermicin A | NRPS:Type I+PKS

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 1,315,781 | 1,336,671 |  |
Region 1.2 | terpene | 2,012,389 | 2,034,242 | Low | molybdenum cofactor | other:other
Region 1.3 | NRPS | 2,817,423 | 2,864,439 |
Region 1.4 | RiPP-like | 2,882,837 | 2,893,097 |
Region 1.5 | RiPP-like | 2,991,338 | 3,001,667 |
Region 1.6 | betalactone | 3,052,726 | 3,077,964 | Low | fengycin | NRPS:Type I
Region 1.7 | NRPS | 3,123,457 | 3,189,365 |
Region 1.8 | NRP-metallophore,NRPS | 3,279,673 | 3,331,421 | High | bacillibactin | NRPS:Type I
Region 1.9 | NI-siderophore | 3,614,931 | 3,646,638 | High | petrobactin | other:other
Region 1.10 | azole-containing-RiPP | 4,243,075 | 4,266,581 |
Region 1.11 | NRPS,RRE-containing | 4,555,010 | 4,598,314 |  |
Region 1.12 | NRPS-like | 5,054,233 | 5,097,814 |
Region 4.1 | lanthipeptide-class-ii | 1 | 15,015 |
Region 4.2 | lanthipeptide-class-ii | 364,622 | 387,810 |  |
Region 4.3 | NRPS,T1PKS,NRPS-like,lanthipeptide-class-ii | 406,039 | 515,563 | High | zwittermicin A | NRPS:Type I+PKS

No secondary metabolite regions were found in these records:
  NZ_KB976301.1 (Bacillus cereus K-5975c)
  NZ_KB976302.1 (Bacillus cereus K-5975c)
  NZ_KB976304.1 (Bacillus cereus K-5975c)
  NZ_KB976305.1 (Bacillus cereus K-5975c)
  NZ_KB976306.1 (Bacillus cereus K-5975c)
  NZ_KB976307.1 (Bacillus cereus K-5975c)
  NZ_KB976308.1 (Bacillus cereus K-5975c)
  NZ_KB976309.1 (Bacillus cereus K-5975c)
  NZ_KB976310.1 (Bacillus cereus K-5975c)

Compact view
NZ_KB976300.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,315,781 - 1,336,671 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
IGY_RS06755: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
IGY_RS06785: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

IGY_RS06790: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
IGY_RS06785: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_KB976300.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,012,389 - 2,034,242 nt. (total: 21,854 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
IGY_RS10315: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

IGY_RS10320: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Lyases: lyase
IGY_RS10345: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.53 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.53 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
IGY_RS10305: T2TS
Domain 1 (4 - 614): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 26.42 out of 30.22
Confidence: medium
Additional weak hits (1):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.61 out of 36.54
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ClgR | Caseinolytic protease gene regulator

NZ_KB976300.1 - Region 3 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,817,423 - 2,864,439 nt. (total: 47,017 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
IGY_RS14365: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

Transferases: aminotransferase
IGY_RS14240: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase
IGY_RS14230: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

IGY_RS14270: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

IGY_RS14280: Pullulanase, type I

smcogs
  SMCOG1297: Pullulanase, type I

IGY_RS14300: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: decarboxylase
IGY_RS14295: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
IGY_RS14290: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.66 out of 25.88
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.58 out of 20.97
Confidence: medium
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
Additional weak hits (7):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.76 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.69 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.02 out of 32.74
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.63 out of 29.65
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.70 out of 18.46
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 2817422 - 2864439:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS14290: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (268..658): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FVMAFDISLLELESLLAGELNIYGPTETTICATV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1305..1685): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
HexR | Glucose-responsive regulator
MexT | Global virulence regulator
PsrA | Oleic acid responsive regulator

NZ_KB976300.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,882,837 - 2,893,097 nt. (total: 10,261 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
IGY_RS14535: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.

No matches found.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.32 out of 26.06
Confidence: strong
Additional weak hits (1):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_KB976300.1 - Region 5 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,991,338 - 3,001,667 nt. (total: 10,330 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
IGY_RS15140: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000896.5 |  | 0.29 | other (other) | cycloserine | Streptomyces lavendulae subsp. lavendulae
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina
BGC0001459.5 |  | 0.21 | NRPS | decaplanin | Amycolatopsis regifaucium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.22 out of 24.78
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.87 out of 32.93
Confidence: medium
Additional weak hits (2):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_KB976300.1 - Region 6 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,052,726 - 3,077,964 nt. (total: 25,239 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
IGY_RS15470: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase
IGY_RS15425: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

IGY_RS15445: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

IGY_RS15465: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase
IGY_RS15450: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
IGY_RS15440: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

IGY_RS15455: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
Additional weak hits (2):
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.04 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.69 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ToxT | Regulator of MSHA biosynthesis

NZ_KB976300.1 - Region 7 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,123,457 - 3,189,365 nt. (total: 65,909 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
IGY_RS15715: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

IGY_RS15780: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acetyltransferase acyltransferase aminotransferase
IGY_RS15710: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

IGY_RS15730: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

IGY_RS15790: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

IGY_RS15820: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

IGY_RS15830: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: deacetylase esterase
IGY_RS15785: thioesterase

smcogs
  SMCOG1004: thioesterase

IGY_RS15870: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: dehydratase
IGY_RS15705: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: mutase
IGY_RS15895: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase
IGY_RS15795: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS15800: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS15805: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.73 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.73 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.92 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.02 out of 23.79
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.20 out of 20.01
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.25 out of 24.78
Confidence: medium
Additional weak hits (7):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.25 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 3123456 - 3189365:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS15795: Ser - Leu - X - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2600..3000): X
nrpys: Gln, Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (88% 8Å match)
    Ile DAQDLGVVDK (85% 8Å match)
    Gln DAQDLGVVDK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4115..4515): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (85% 8Å match)
    Ile DAQDLGVVDK (82% 8Å match)
    Gln DAQDLGVVDK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

IGY_RS15800: X - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1527..1919): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

IGY_RS15805: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response

NZ_KB976300.1 - Region 8 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,279,673 - 3,331,421 nt. (total: 51,749 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
IGY_RS16420: Antibiotic biosynthesis monooxygenase

smcogs
  SMCOG1258: Antibiotic biosynthesis monooxygenase

IGY_RS16500: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

IGY_RS16555: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

IGY_RS16560: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

IGY_RS16565: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase
IGY_RS16465: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease
IGY_RS16440: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

IGY_RS16485: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Lyases: hydratase
IGY_RS16545: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase
IGY_RS16495: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthase
IGY_RS16415: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

IGY_RS16480: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS16490: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.05 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.89 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  | 0.87 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  | 0.86 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.75 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.74 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.99 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.57 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.90 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.41 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.53 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.21 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
Additional weak hits (6):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.23 out of 31.73
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.05 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.49 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.83 out of 32.74
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 3279672 - 3331421:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS16480: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (464..864): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNLYGPTETTIWSTF
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1524..1937): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

IGY_RS16490: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPAQGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_KB976300.1 - Region 9 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,614,931 - 3,646,638 nt. (total: 31,708 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
IGY_RS18085: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
IGY_RS18150: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase
IGY_RS18120: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

IGY_RS18175: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.5 |  | 0.48 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001572.3 |  | 0.51 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0001713.5 |  | 0.48 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002633.2 |  | 0.47 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.38 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.99 out of 30.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.93 out of 28.19
Confidence: medium
Additional weak hits (5):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.66 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.50 out of 32.74
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_KB976300.1 - Region 10 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,243,075 - 4,266,581 nt. (total: 23,507 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
IGY_RS21330: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93
Confidence: medium
Additional weak hits (4):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 30.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.41 out of 30.12
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (4243074...4266581)
IGY_RS21305
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 184.8
  RRE type: Thiopeptide_F_RRE
  Location: 10 - 89
  Score: 41.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_KB976300.1 - Region 11 - NRPS,RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,555,010 - 4,598,314 nt. (total: 43,305 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deaminase
IGY_RS23030: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: lyase
IGY_RS22950: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase
IGY_RS22960: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002164.2 |  |  | 0.59 | NRPS | peramine | Epichloe festucae
BGC0002276.2 |  |  | 0.49 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002458.3 |  |  | 0.37 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0001135.5 |  |  | 0.34 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000308.5 |  |  | 0.33 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0001261.3 |  |  | 0.33 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  |  | 0.32 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  | 0.32 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  |  | 0.31 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  |  | 0.31 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002164.2 |  | 0.68 | NRPS | peramine | Epichloe festucae
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001240.4 |  | 0.64 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.85 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.31 out of 18.16
Confidence: strong
Additional weak hits (6):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.40 out of 20.01
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 18.97 out of 29.51
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.90 out of 30.22
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.09 out of 33.14
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
RREFinder
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 11, location 4555009 - 4598314:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS22960: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (18..408): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSSAFDASVFETLLISAGSINAYGPTETTVYTVA
  Nearest Stachelhaus code(s):
    Leu DAFLIGAVMK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

Link to PARAS substrate predictor
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (4555744...4576848)
IGY_RS22935
  RRE type: Pantocin_Microcin_RRE
  Location: 0 - 94
  Score: 93.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
RpoN | Regulator of nitrogen assimilation and virulence

NZ_KB976300.1 - Region 12 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,054,233 - 5,097,814 nt. (total: 43,582 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
IGY_RS25500: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Transferases: phosphorylase phosphotransferase
IGY_RS25465: thiamine-phosphate pyrophosphorylase

smcogs
  SMCOG1280: thiamine-phosphate pyrophosphorylase

IGY_RS25490: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: glucosidase
IGY_RS25495: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Ligases: ligase
IGY_RS25450: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002174.2 |  | 0.59 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.60 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001758.4 |  | 0.60 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002174.2 |  | 0.59 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78
Confidence: strong
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 25.04 out of 26.12
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.69 out of 21.55
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.91 out of 25.88
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.96 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.55 out of 24.78
Confidence: medium
Additional weak hits (8):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.72 out of 32.74
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.11 out of 20.47
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.78 out of 31.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.98 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 5054232 - 5097814:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS25450: X
AMP-binding (225..621): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWMPFDASVWEAALAIGGEHNVYGPTECTVVTTT
  Nearest Stachelhaus code(s):
    Leu DAWYLGNVVK (71% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
LuxO | Repressor of luminescence
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_KB976303.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 15,015 nt. (total: 15,015 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
IGY_RS26070: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
IGY_RS26060: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.60 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.54 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.53 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.52 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.48 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000516.4 |  | 0.48 | ribosomal | geobacillin II | Geobacillus thermodenitrificans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.60 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.54 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.53 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.52 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.52 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.48 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000516.4 |  | 0.48 | ribosomal | geobacillin II | Geobacillus thermodenitrificans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for IGY_RS26060

IGY_RS26035
Leader:
MKNISEKSVGLSMKKLDTTEMEKIYGA
IGY_RS26045
Leader:
MKNISEKSVGLSMKKLDTTEMEKIYGA
Shared core:
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
Core with dehydrations:
DhaGVDDhbRDhbHPDhbVIVVDhaRADhaDhaKACysMDhaGVDhaAIDhaGLLDhaYNKDCysIG

#### antiSMASH-DB 4.0 matches for IGY_RS26035

100.0%
NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
1
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
41
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
1
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
41
80.5%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
1
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
41
SGVDTRTHPTVIVVSR SS C S +SAISGL+SYNKDC+G
1
SGVDTRTHPTVIVVSRISSAKCASTISAISGLVSYNKDCLG
41
65.9%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26040_lanthipeptide
1
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKD
38
SGVDTRTHPTV+VVSRASSK C++ V ++ LLSYN D
1
SGVDTRTHPTVVVVSRASSKFCVTVVGSV--LLSYNMD
36
with 22 more sequence matches
Only the first 10 are displayed here.
58.3%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17795_lanthipeptide
1
SGVDTRTHPTVIVVSR-------ASSKACMSGVSAISGLLSYNKDCIG
41
SGVDTRTHPTV+V SR ASSK+C+ + I GL+SYNK+C+G
1
SGVDTRTHPTVVVASRITVQASKASSKSCLGAIGGIGGLVSYNKNCLG
48
55.8%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
1
SGVDTRTHPTVIV--VSRASSKACMSGV-SAISGLLSYNKDCIG
41
S V+ R P IV V+R SSK C+S + SAISG++S+NKDC+G
1
SDVEPRGTPATIVSAVTR-SSKPCISAIGSAISGIISHNKDCLG
43
54.3%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08660_lanthipeptide
1
SGVDTRTHPTV---IVVSRA-SSKACMSGV-SAISGLLSYNKDCIG
41
S VD R PT+ I+ S A SSK C+S V SAISG++S NK+C+G
1
SDVDPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG
46
51.1%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16390_lanthipeptide
Lanthipeptides: KNQ12_RS14665_lanthipeptide
1
SGVDTRTHPTVIVVSRA---SSKACM-SGVSAISGLLSYNKDCIG
41
S VD R P + +V+R+ S+KAC+ +G SAISG++S+NKDC+G
1
SDVDPRWTPVISLVARSIVKSTKACIGAGASAISGIVSHNKDCLG
45
48.9%
NC_003028.3 and 39 others:
NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptide NZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide
Lanthipeptides: SP_RS09790_lanthipeptide
2
GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG
41
G + R PT I++ + ASSK C+S VS I GL+SYN DC+G
3
GAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG
45
48.9%
NZ_CP035244.1 and 3 others:
NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide
Lanthipeptides: EQH36_RS09100_lanthipeptide
2
GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG
41
G + R PT I++ + ASSK C+S VS I GL+SYN DC+G
3
GAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG
45
48.8%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
3
VDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKDCIG
41
V+ T P ++ + SSK C+ +SAISGL+SYNKDC+G
4
VEPHTTP-ILSAATKSSKKCLGAISAISGLVSYNKDCLG
41
46.7%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00305_lanthipeptide
4
DTRTHPTVIVVSRA---SSKACMSGV-SAISGLLSYNKDCIG
41
D R P V V A S++ C+SG+ SAISG++S+NKDC+G
4
DPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG
45
46.7%
NZ_JALDUX010000010.1:
Lanthipeptides: M1F92_RS09530_lanthipeptide
2
GVDTRTHPTVIVV--SRASSKACMSG-VSAISGLLSYNKDCIG
41
G + R PT +++ + ASSK C+S VS I GL+SYN DC+G
3
GAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG
45
45.7%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14400_lanthipeptide
1
SGVDTRTHPTVI----VVSRASSKACMSGV-SAISGLLSYNKDCIG
41
S V+ R PT++ R SSK C+S V SAI G+ S+N DC+G
1
SDVEPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG
46
IGY_RS26040
Leader:
MKNISEKSVGLSMKKLDTTEMEKIYGA
Core:
SGVDTRTHPTVVVVSRASSKFCVTVVGSVLLSYNMDKC
Core with dehydrations:
DhaGVDDhbRDhbHPDhbVVVVDhaRADhaDhaKFCysVDhbVVGDhaVLLDhaYNMDKCys

#### antiSMASH-DB 4.0 matches for IGY_RS26040

100.0%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26040_lanthipeptide
1
SGVDTRTHPTVVVVSRASSKFCVTVVGSVLLSYNMDKC
38
SGVDTRTHPTVVVVSRASSKFCVTVVGSVLLSYNMDKC
1
SGVDTRTHPTVVVVSRASSKFCVTVVGSVLLSYNMDKC
38
65.9%
NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
1
SGVDTRTHPTVVVVSRASSKFCVTVVGSV--LLSYNMD
36
SGVDTRTHPTV+VVSRASSK C++ V ++ LLSYN D
1
SGVDTRTHPTVIVVSRASSKACMSGVSAISGLLSYNKD
38
56.1%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
1
SGVDTRTHPTVVVVSRASSKFCVTVVGSV--LLSYNMD
36
SGVDTRTHPTV+VVSR SS C + + ++ L+SYN D
1
SGVDTRTHPTVIVVSRISSAKCASTISAISGLVSYNKD
38
with 15 more sequence matches
Only the first 10 are displayed here.
41.7%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17795_lanthipeptide
1
SGVDTRTHPTVVVVSR-------ASSKFC
22
SGVDTRTHPTVVV SR ASSK C
1
SGVDTRTHPTVVVASRITVQASKASSKSC
29
37.2%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
1
SGVDTRTHPTVVV--VSRASSKFCVTVVGSV---LLSYNMD
36
S V+ R P +V V+R SSK C++ +GS ++S+N D
1
SDVEPRGTPATIVSAVTR-SSKPCISAIGSAISGIISHNKD
40
34.8%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14400_lanthipeptide
1
SGVDTRTHPTVV----VVSRASSKFCVTVVGSV---LLSYNMD
36
S V+ R PT+V R SSK C+++V S + S+N D
1
SDVEPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNND
43
33.3%
NC_003028.3 and 39 others:
NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptide NZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide
Lanthipeptides: SP_RS09790_lanthipeptide
2
GVDTRTHPTVVVV--SRASSKFCVTVVGS---VLLSYNMD
36
G + R PT +++ + ASSK C++ S L+SYN D
3
GAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNND
42
33.3%
NZ_CP035244.1 and 3 others:
NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide
Lanthipeptides: EQH36_RS09100_lanthipeptide
2
GVDTRTHPTVVVV--SRASSKFCVTVVGS---VLLSYNMD
36
G + R PT +++ + ASSK C++ S L+SYN D
3
GAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNND
42
33.3%
NZ_JALDUX010000010.1:
Lanthipeptides: M1F92_RS09530_lanthipeptide
2
GVDTRTHPTVVVV--SRASSKFCVTVVGS---VLLSYNMD
36
G + R PT +++ + ASSK C++ + S L+SYN D
3
GAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNND
42
33.3%
NZ_JAMYJM010000002.1:
Lanthipeptides: NKE69_RS04880_lanthipeptide
2
GVDTRTHPTVVVV--SRASSKFCVTVVGS---VLLSYNMD
36
G + R PT ++ + ASSK C++ V S ++SYN D
3
GAEPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNND
42
32.6%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08660_lanthipeptide
1
SGVDTRTHPTVVV-VSRA---SSKFCVTVVGSVL
30
S VD R PT+V + R+ SSK C++ VGS +
1
SDVDPRATPTIVASIIRSVAQSSKVCISAVGSAI
34
29.3%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
3
VDTRTHPTVVVVSRASSKFCVTVVGSV--LLSYNMD
36
V+ T P + ++ SSK C+ + ++ L+SYN D
4
VEPHTTPILSAATK-SSKKCLGAISAISGLVSYNKD
38
28.9%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00305_lanthipeptide
3
VDTRTHPTVVVVSRA---SSKFCVTVVGSV---LLSYNMD
36
D R P V V A S++ C++ +GS ++S+N D
3
ADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKD
42
IGY_RS26050
Leader:
MSTLKENVVGLSMKKLDTTEMEKIYGA
Core:
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
Core with dehydrations:
DhaGVDPRDhbDhbPDhaPLLADhaFVADhaYIADhaAQFRCysGKDNKGK

#### antiSMASH-DB 4.0 matches for IGY_RS26050

100.0%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26050_lanthipeptide
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
35
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
35
97.1%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24355_lanthipeptide
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
35
SGVDPRTTPSPLLASFVASYIASA+FRCGKDNKGK
1
SGVDPRTTPSPLLASFVASYIASAEFRCGKDNKGK
35
97.1%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24360_lanthipeptide
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
35
SGVDPRTTPSPLLASFVASYIASAQ+RCGKDNKGK
1
SGVDPRTTPSPLLASFVASYIASAQYRCGKDNKGK
35
with 28 more sequence matches
Only the first 10 are displayed here.
94.3%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17790_lanthipeptide
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNKGK
35
SGVDPRTTPSPLLASFVASYIASA+F+CGKDNKGK
1
SGVDPRTTPSPLLASFVASYIASAEFKCGKDNKGK
35
82.9%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27545_lanthipeptide
1
SGVDPRTTP-SPLLASFVASYIASAQFRCGKDNK
33
SGV PRTTP + LLASFVASYIASA+FRCGKDNK
1
SGVTPRTTPATTLLASFVASYIASAEFRCGKDNK
34
59.5%
NZ_NAOJ01000022.1:
Lanthipeptides: B5K31_RS08015_lanthipeptide
2
GVDPR-TTPSPLLASFVASYIASAQFRCGKDNKGK
35
G DPR TT SF+ASY+ SAQ RCGKDNK K
3
GADPRSTTICSATLSFIASYLGSAQTRCGKDNKKK
37
57.1%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18395_lanthipeptide
1
SGVDPRTTPSPLLASFVASYIASAQFRCGKDNK
33
S + P++TP L SF+ASYI SAQF+CG DNK
3
SEIQPQSTP---LCSFLASYIISAQFKCGGDNK
32
56.8%
NC_003028.3 and 45 others:
NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptide NZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptide NZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptide NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptide NZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptide NZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide
Lanthipeptides: SP_RS09795_lanthipeptide
2
GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK
35
G DPR+T SF+ASY+ SAQ RCGKDNK K
3
GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK
37
55.3%
NZ_CP084237.1:
Lanthipeptides: RES5_RS11640_lanthipeptide
1
SGVDPRTTPSPLLASFVAS----YIASAQFRCGKDNK
33
S V+ R TP+ +ASFVA+ Y ASA F+CGKDNK
1
SEVELRGTPTIGIASFVATIPTGYTASAAFKCGKDNK
37
54.1%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06305_lanthipeptide
2
GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK
35
G DPR++ SF+ASY+ SAQ RCGKDNK K
3
GADPRSSIICSATLSFIASYLGSAQTRCGKDNKKK
37
51.4%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08665_lanthipeptide
1
SGVDPRTTPSPLLA---SFVASYIASAQFRCGKDNK
33
+G+D + L SFVASY+ASA F+CGKDNK
1
TGMDAEVRSTLLCGMGISFVASYLASAAFKCGKDNK
36
50.0%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide
Lanthipeptides: KNQ12_RS14670_lanthipeptide
3
VDPRTT-PSPLLASFVASYIASAQFRCGKDNK
33
VD R++ L SFV SY+ASA +CGKDNK
4
VDVRSSLVCSALLSFVGSYLASAGLKCGKDNK
35
47.4%
NZ_LWAG01000079.1:
Lanthipeptides: A4R27_RS25235_lanthipeptide
1
SGVDPRTTPSPLLA---SFVASYIASAQFRCGKDNKGK
35
SG+D + + S + SY+ASA F+CGKDNKGK
1
SGMDAEARSTLICGAGISLIGSYLASAAFKCGKDNKGK
38
allorf_012212_012337
Leader:
MFHLFILSKKELVVMPTS
Core:
SFCIFYHFNQGDTYQNEGESNDD
Core with dehydrations:
DhaFCysIFYHFNQGDDhbYQNEGEDhaNDD

#### antiSMASH-DB 4.0 matches for allorf_012212_012337

100.0%
NZ_FNYB01000021.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: allorf_012212_012337_lanthipeptide
Lanthipeptides: allorf_11517_11642_lanthipeptide
1
SFCIFYHFNQGDTYQNEGESNDD
23
SFCIFYHFNQGDTYQNEGESNDD
1
SFCIFYHFNQGDTYQNEGESNDD
23
78.3%
NZ_CM000758.1:
Lanthipeptides: allorf_3265670_3265795_lanthipeptide
1
SFCIFYHFNQGDTYQNEGESNDD
23
SFCIFY FNQ DTYQN+ ES+DD
1
SFCIFYDFNQEDTYQNKDESSDD
23
allorf_012390_012482
Leader:
MEFLTNRDEISFA
Core:
NSRNFHTLKRCMLIFVI
Core with dehydrations:
NDhaRNFHDhbLKRCysMLIFVI

#### antiSMASH-DB 4.0 matches for allorf_012390_012482

100.0%
NZ_FNYB01000021.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: allorf_012390_012482_lanthipeptide
Lanthipeptides: allorf_11695_11787_lanthipeptide
1
NSRNFHTLKRCMLIFVI
17
NSRNFHTLKRCMLIFVI
1
NSRNFHTLKRCMLIFVI
17
allorf_014304_014375
Leader:
MHIFNRLEEVLFM
Core:
LFSSCRWDYL
Core with dehydrations:
LFDhaDhaCysRWDYL

#### antiSMASH-DB 4.0 matches for allorf_014304_014375

100.0%
NZ_FNYB01000021.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: allorf_014304_014375_lanthipeptide
Lanthipeptides: allorf_13609_13680_lanthipeptide
1
LFSSCRWDYL
10
LFSSCRWDYL
1
LFSSCRWDYL
10
38.5%
NZ_AP026714.1 and 3 others:
NZ_KZ845958.1 Lanthipeptides: allorf_1543968_1544045_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: allorf_000071_000148_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: allorf_1658910_1658987_lanthipeptide
Lanthipeptides: allorf_1208347_1208424_lanthipeptide
2
FSSCRW
7
FSSCR+
8
FSSCRY
13
26.7%
NZ_BMRZ01000004.1 and 14 others:
NZ_BMRZ01000004.1 Lanthipeptides: IE237_RS41350_lanthipeptide NZ_BMTQ01000003.1 Lanthipeptides: IE180_RS37115_lanthipeptide NZ_BMTQ01000003.1 Lanthipeptides: IE180_RS37115_lanthipeptide NZ_CP010407.1 Lanthipeptides: allorf_7945111_7945305_lanthipeptide NZ_CP010407.1 Lanthipeptides: allorf_7945111_7945305_lanthipeptide NZ_CP029194.1 Lanthipeptides: DEJ46_RS40445_lanthipeptide NZ_CP030286.1 Lanthipeptides: DRB89_RS43760_lanthipeptide NZ_CP059991.1 Lanthipeptides: H4W23_RS41725_lanthipeptide NZ_CP071139.1 Lanthipeptides: JYK04_RS32930_lanthipeptide NZ_CP071139.1 Lanthipeptides: JYK04_RS32930_lanthipeptide NZ_CP084204.1 Lanthipeptides: LDH80_RS35825_lanthipeptide NZ_CP084204.1 Lanthipeptides: LDH80_RS35825_lanthipeptide NZ_JACHJY010000002.1 Lanthipeptides: GGE06_RS41990_lanthipeptide NZ_JACHJY010000002.1 Lanthipeptides: GGE06_RS41990_lanthipeptide
Lanthipeptides: IE237_RS41350_lanthipeptide
1
LFSSCRW
7
L ++CRW
4
LITACRW
10
with 4 more sequence matches
23.8%
NC_017803.1 and 3 others:
NZ_CP028158.1 Lassopeptides: C6361_RS36275_lassopeptide NZ_CP028159.1 Lassopeptides: C6W10_RS16340_lassopeptide NZ_LT607413.1 Lassopeptides: GA0070618_RS33740_lassopeptide
Lassopeptides: ACPL_RS46435_lassopeptide
1
LFSSCRWDYL
10
LF+SCR ++
3
LFTSCRESFV
12
23.8%
NZ_JALJRJ010000031.1:
Lassopeptides: OC439_RS28220_lassopeptide
1
LFSSCRWDYL
10
LF++CR Y+
3
LFTNCRESYV
12
21.4%
NZ_CP035088.1 and 1 other:
NZ_CP087200.1 Lanthipeptides: allorf_5645333_5645458_lanthipeptide
Lanthipeptides: allorf_5771774_5771899_lanthipeptide
2
FSSCRWDYL
10
F CRW YL
4
FIDCRWCYL
12
20.8%
NC_013928.1 and 4 others:
NZ_CP023477.1 Lanthipeptides: CO204_RS01890_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01095_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01750_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07560_lanthipeptide
Lanthipeptides: SMUNN2025_RS09965_lanthipeptide
1
LFSSCRWDYL
10
+ S CRW+ L
8
ISSDCRWNSL
17
allorf_014456_014554
Leader:
MIDIDKLLGS
Core:
ANEELRYKSCDGSLYRGKGRTK
Core with dehydrations:
ANEELRYKDhaCysDGDhaLYRGKGRDhbK

#### antiSMASH-DB 4.0 matches for allorf_014456_014554

100.0%
NZ_FNYB01000021.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: allorf_014456_014554_lanthipeptide
Lanthipeptides: allorf_13761_13859_lanthipeptide
1
ANEELRYKSCDGSLYRGKGRTK
22
ANEELRYKSCDGSLYRGKGRTK
1
ANEELRYKSCDGSLYRGKGRTK
22
17.9%
NZ_LR134504.1:
Lanthipeptides: allorf_1621406_1621576_lanthipeptide
1
ANEELRYKSCDGSLYRGKG
19
A +L++ +C+ L+RG G
10
AGLKLQFSTCEAWLWRGVG
28
12.7%
NZ_EQ973330.1:
Lanthipeptides: allorf_437242_437442_lanthipeptide
1
ANEELRYKSCDGSLYRGKG
19
A +L+ +C+ L+RG G
1
AFLKLQLSTCEAWLWRGVG
19

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.53 out of 30.25
Confidence: medium
Additional weak hits (1):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.04 out of 23.43
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

IGY_RS26035 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3968.1 Da
  Molecular weight: 3970.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3988.5 Da N = 1
    4006.6 Da N = 2
    4024.6 Da N = 3
    4042.6 Da N = 4
    4060.6 Da N = 5
    4078.6 Da N = 6
    4096.7 Da N = 7
    4114.7 Da N = 8
    4132.7 Da N = 9
IGY_RS26040 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3861.0 Da
  Molecular weight: 3863.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3881.5 Da N = 1
    3899.5 Da N = 2
    3917.5 Da N = 3
    3935.5 Da N = 4
    3953.5 Da N = 5
    3971.6 Da N = 6
    3989.6 Da N = 7
    4007.6 Da N = 8
IGY_RS26045 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3968.1 Da
  Molecular weight: 3970.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3988.5 Da N = 1
    4006.6 Da N = 2
    4024.6 Da N = 3
    4042.6 Da N = 4
    4060.6 Da N = 5
    4078.6 Da N = 6
    4096.7 Da N = 7
    4114.7 Da N = 8
    4132.7 Da N = 9
IGY_RS26050 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3541.9 Da
  Molecular weight: 3544.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3562.0 Da N = 1
    3580.0 Da N = 2
    3598.0 Da N = 3
    3616.1 Da N = 4
    3634.1 Da N = 5
    3652.1 Da N = 6
allorf_012212_012337 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 2675.1 Da
  Molecular weight: 2676.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2694.7 Da N = 1
    2712.7 Da N = 2
allorf_012390_012482 - Class II
  Cleavage pHMM score: -2.60
  RODEO score: 0
  Monoisotopic mass: 2055.1 Da
  Molecular weight: 2056.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2074.5 Da N = 1
allorf_014304_014375 - Class II
  Cleavage pHMM score: 0.20
  RODEO score: 0
  Monoisotopic mass: 1252.6 Da
  Molecular weight: 1253.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1271.4 Da N = 1
allorf_014456_014554 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2476.3 Da
  Molecular weight: 2477.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2495.8 Da N = 1
    2513.8 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator

NZ_KB976303.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 364,622 - 387,810 nt. (total: 23,189 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
IGY_RS27685: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
IGY_RS27700: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.63 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.57 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.48 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.63 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.57 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001407.5 |  | 0.49 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.48 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001555.4 |  | 0.47 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for IGY_RS27700

IGY_RS27690
Leader:
MNRNQIIEELAVNHPAGAKLVEVSKEELTRVYGG
Core:
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
Core with dehydrations:
GDVQPEDhbDhaPACysADhaAMLYLQGVDhbVDhaLGLDhaRMHCys

#### antiSMASH-DB 4.0 matches for IGY_RS27690

100.0%
NZ_FNYB01000007.1 and 2 others:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27185_lanthipeptide NZ_KB976303.1 Lanthipeptides: IGY_RS27690_lanthipeptide
Lanthipeptides: BMZ34_RS15965_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
56.2%
NZ_FTML01000041.1:
Lanthipeptides: BW937_RS20035_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPETSPAC LY GV + + LS C
1
GDVQPETSPAC----LYTGGVVIGVTLSIWKC
28
56.2%
NZ_JAEKEJ010000007.1:
Lanthipeptides: JFU02_RS02780_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+P C S + Y G+T+ L LSR C
1
GDVQPETTPLCVSTIWYANGITIGLALSRQSC
32
with 114 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CP012102.1 and 1 other:
NZ_CP012102.1 Lanthipeptides: AC241_RS31295_lanthipeptide
Lanthipeptides: AC241_RS31385_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPETSPACA G+ V+ +S +C
1
GDVQPETSPACAVGGAVAGGLWVAHTVSYWNC
32
50.0%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08030_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+ CA Y GVT+ + LS C
1
GDVQPETTTPCA----YTIGVTIGITLSMWKC
28
50.0%
NZ_JAEKEJ010000007.1:
Lanthipeptides: JFU02_RS02775_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+P CA + GV + L LS+++C
1
GDVQPETTPICA----FGSGVALGLSLSKIYC
28
50.0%
NZ_JAHHYI010000012.1:
Lanthipeptides: KM925_RS25405_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+PAC A G+TV + +S++ C
1
GDVQPETTPACVGA-----GITVGIAISKLLC
27
46.9%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRM
30
GDV+PET+PAC L G TV LG+ +
1
GDVKPETTPAC------LAGFTVGLGIGAL
24
46.9%
NZ_FTML01000041.1:
Lanthipeptides: BW937_RS20030_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPE++PAC A G+TV + +S++ C
1
GDVQPESTPACVGA-----GITVGIAISKLLC
27
46.9%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12700_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRM---HC
32
GDVQ ET+PACA + + VS G+ + HC
1
GDVQVETTPACA----FTASILVSYGVVKTIKGHC
31
45.7%
NZ_PVRU01000017.1 and 3 others:
NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28260_lanthipeptide NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28255_lanthipeptide
Lanthipeptides: C6360_RS28260_lanthipeptide
1
GDVQPETSPAC---ASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+PA S +L G+T+S+ +S+ +C
1
GDVQPETTPAATLITSTVLCANGLTISIAVSKSYC
35
43.8%
NZ_CP048887.1:
Lanthipeptides: BMG_RS29410_lanthipeptide
1
GDVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
GDVQPET+P S+ + G V + LS+ C
1
GDVQPETTPLTISS--WGCGAGVGVLLSKAFC
30
43.8%
NZ_CP062165.1 and 5 others:
NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17170_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptide
Lanthipeptides: JNUCC31_RS17170_lanthipeptide
2
DVQPETSPACASAMLYLQGVTVSLGLSRMHC
32
DVQPET+P C +L GV + + LS C
2
DVQPETTPLCG----FLVGVGIGVILSVTSC
28
IGY_RS27695
Leader:
MNRNEVIEELAVNHPAGAKLVEVSKEELTRIYAG
Core:
GDVQPETTPVCAIGGGLALGFSISKIYC
Core with dehydrations:
GDVQPEDhbDhbPVCysAIGGGLALGFDhaIDhaKIYCys

#### antiSMASH-DB 4.0 matches for IGY_RS27695

100.0%
NZ_FNYB01000007.1 and 2 others:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27180_lanthipeptide NZ_KB976303.1 Lanthipeptides: IGY_RS27695_lanthipeptide
Lanthipeptides: BMZ34_RS15960_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPETTPVCAIGGGLALGFSISKIYC
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
78.6%
NZ_JAEKEJ010000007.1:
Lanthipeptides: JFU02_RS02775_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPETTP+CA G G+ALG S+SKIYC
1
GDVQPETTPICAFGSGVALGLSLSKIYC
28
71.4%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08040_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPETT VCAIGGG++LG ++SK++C
1
GDVQPETTTVCAIGGGISLGIALSKLFC
28
with 116 more sequence matches
Only the first 10 are displayed here.
64.3%
NZ_NHVL01000036.1:
Lanthipeptides: CEU70_RS27675_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDV PETTPVC I G A G+ ISK+ C
1
GDVSPETTPVC-ITVGAATGYVISKVLC
27
60.7%
NZ_JAHHYI010000012.1:
Lanthipeptides: KM925_RS25405_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPETTP C +G G+ +G +ISK+ C
1
GDVQPETTPAC-VGAGITVGIAISKLLC
27
57.1%
NZ_FTML01000041.1:
Lanthipeptides: BW937_RS20030_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPE+TP C +G G+ +G +ISK+ C
1
GDVQPESTPAC-VGAGITVGIAISKLLC
27
57.1%
NZ_JAOVZP010000016.1 and 1 other:
NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide
Lanthipeptides: OF830_RS26680_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDV PETTP+C I G+ G +ISK+ C
1
GDVSPETTPLC-ITIGVGGGIAISKLIC
27
57.1%
NZ_NHVL01000036.1:
Lanthipeptides: CEU70_RS27670_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDV PETTP C I GG+ G+ +SK C
1
GDVSPETTPACIIAGGIG-GYYLSKAIC
27
53.6%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQ ETTPVC GL +G +S C
1
GDVQAETTPVC-FTIGLGVGALVSAAGC
27
53.6%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08035_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPET+P C + G+ +G ISK++C
1
GDVQPETSPAC-VTIGIGIGIGISKLFC
27
53.6%
NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQPETTP C G+ +G +IS C
1
GDVQPETTPFCV---GVIVGVTISLSKC
25
53.6%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11325_lanthipeptide
2
DVQPETTPVCAIGGGLALGFSISKIYC
28
DVQPETTPVC G+ +G IS C
2
DVQPETTPVCGFFVGVGIGAIISATAC
28
53.6%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide
Lanthipeptides: IKS_RS03660_lanthipeptide
1
GDVQPETTPVCAIGGGLALGFSISKIYC
28
GDVQ ETTPVC GL +G +S C
1
GDVQAETTPVC-FTVGLGIGSLVSASVC
27
IGY_RS33990
Leader:
MKDVSSIFM
Core:
REKIASSYLYFFSCFGYYNYIFT
Core with dehydrations:
REKIADhaDhaYLYFFDhaCysFGYYNYIFDhb

#### antiSMASH-DB 4.0 matches for IGY_RS33990

100.0%
NZ_KB976303.1:
Lanthipeptides: IGY_RS33990_lanthipeptide
1
REKIASSYLYFFSCFGYYNYIFT
23
REKIASSYLYFFSCFGYYNYIFT
1
REKIASSYLYFFSCFGYYNYIFT
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.04 out of 24.78
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.10 out of 25.88
Confidence: medium
Additional weak hits (2):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.99 out of 20.01
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 25.37 out of 35.63
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

IGY_RS27690 - Class II
  Cleavage pHMM score: 0.60
  RODEO score: 0
  Monoisotopic mass: 3212.6 Da
  Molecular weight: 3214.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3232.7 Da N = 1
    3250.7 Da N = 2
    3268.7 Da N = 3
    3286.8 Da N = 4
IGY_RS27695 - Class II
  Cleavage pHMM score: -1.50
  RODEO score: 0
  Monoisotopic mass: 2723.4 Da
  Molecular weight: 2725.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2743.1 Da N = 1
    2761.2 Da N = 2
IGY_RS33990 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 2809.3 Da
  Molecular weight: 2811.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2829.2 Da N = 1
    2847.2 Da N = 2
    2865.2 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis

NZ_KB976303.1 - Region 3 - NRPS,NRPS-like,T1PKS,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 406,039 - 515,563 nt. (total: 109,525 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
IGY_RS27920: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

IGY_RS27965: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

IGY_RS27980: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

IGY_RS27990: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

IGY_RS28005: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

IGY_RS28065: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: PPTase acylase carbamoyltransferase
IGY_RS27975: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

IGY_RS28040: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

IGY_RS28075: ornithine carbamoyltransferase

smcogs
  SMCOG1114: ornithine carbamoyltransferase

Hydrolases: deaminase esterase hydrolase phosphatase
IGY_RS28010: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

IGY_RS28015: FkbH like protein

smcogs
  SMCOG1256: FkbH like protein

IGY_RS28025: thioesterase

smcogs
  SMCOG1004: thioesterase

IGY_RS28035: thioesterase

smcogs
  SMCOG1004: thioesterase

IGY_RS28085: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: cyclase decarboxylase
IGY_RS27915: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

IGY_RS28105: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase synthase
IGY_RS27925: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS27945: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

IGY_RS27950: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS27955: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS27995: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

IGY_RS28000: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS28020: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

IGY_RS28030: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

IGY_RS28080: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | NRPS-like | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000626.3 |  |  |  |  | 1.72 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001059.5 |  |  |  |  | 1.68 | NRPS, PKS | zwittermicin A | Bacillus cereus
BGC0001249.5 |  |  |  |  | 1.30 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001833.4 |  |  |  |  | 1.28 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002075.3 |  |  |  |  | 1.27 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  |  |  |  | 1.27 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  | 1.26 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  |  |  | 1.26 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  |  |  |  | 1.23 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  |  |  | 1.22 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001059.5 |  | 0.92 | NRPS, PKS | zwittermicin A | Bacillus cereus
BGC0000626.3 |  | 0.88 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001833.4 |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.76 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.75 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.75 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001249.5 |  | 0.74 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001758.4 |  | 0.74 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for IGY_RS28105

IGY_RS28100
Leader:
MENEKYLQVVEDEELEQLVGG
Core:
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
Core with dehydrations:
IGPGYIEDhbLDhbKDCysPRVDhbPQICysVPINGIWDhbCysKRCysY

#### antiSMASH-DB 4.0 matches for IGY_RS28100

100.0%
NZ_FNYB01000007.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide
Lanthipeptides: BMZ34_RS15340_lanthipeptide
1
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
1
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
58.8%
NZ_CM000731.1 and 2 others:
NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptide NZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide
Lanthipeptides: BCERE0020_RS28875_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
GPG++ETLTKDCP P CV I G CK+CY
2
GPGWVETLTKDCPWKQPAACVIIMGQKICKKCY
34
58.8%
NZ_CM000748.1 and 1 other:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide
Lanthipeptides: BTHUR0003_RS30910_lanthipeptide
1
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
IGPG++ETLTKDCP P CV I G CK+C
1
IGPGWVETLTKDCPWNMPVACVTIMGQRICKKC
33
with 37 more sequence matches
Only the first 10 are displayed here.
58.8%
NZ_CP036053.1 and 7 others:
NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptide NZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptide NZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptide NZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptide NZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptide NZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptide NZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide
Lanthipeptides: EXW64_RS27135_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
GPG++ETLTKDCP P CV I G CK+CY
2
GPGWVETLTKDCPWKQPGACVIIMGQKICKKCY
34
58.8%
NZ_JH792312.1 and 1 other:
NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide
Lanthipeptides: IIG_RS24665_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
GPG++ETLTKDCP P CV I G CK+CY
2
GPGWVETLTKDCPWNVPVACVTIMGQRICKKCY
34
58.8%
NZ_KB976276.1:
Lanthipeptides: IIC_RS09105_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
GPG++ETLTKDCP P CV I G CK+CY
2
GPGWVETLTKDCPWKQPVACVIIMGQKICKKCY
34
55.9%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide
Lanthipeptides: EXW47_RS29185_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRCY
34
GPG++ET+TKDCP P CV I G CK+CY
2
GPGWVETVTKDCPWNVPVACVTIMGQRICKKCY
34
55.9%
NZ_KB976165.1:
Lanthipeptides: ICC_RS24850_lanthipeptide
1
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
IGPG++ETLTKDCP P C+ I G CK+C
1
IGPGWVETLTKDCPGYKPYACITIAGQTICKKC
33
52.9%
NZ_CM000758.1 and 1 other:
NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide
Lanthipeptides: BTHUR0013_RS15850_lanthipeptide
1
IGPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
+GPG+I TLTKDCP P C+ I G CK+C
1
VGPGWIATLTKDCPANKPYACITIAGQTICKKC
33
50.0%
NZ_AQQB01000068.1 and 6 others:
NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptide NZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptide NZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptide NZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptide NZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptide NZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide
Lanthipeptides: K738_RS01000000110290_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
G G ++TLTKDCP ICV I I CK C
2
GSGLVKTLTKDCPGFLSNICVNIGFISGCKNC
33
47.1%
NC_017621.1 and 16 others:
NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptide NZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptide NZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptide NZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptide NZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptide NZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptide NZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptide NZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptide NZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptide NZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptide NZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptide NZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptide NZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptide NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptide NZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide
Lanthipeptides: SSUD12_RS06540_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
G G+++TLTKDCP +CV I I CK C
2
GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC
33
47.1%
NZ_CP040409.1 and 4 others:
NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptide NZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide
Lanthipeptides: FE336_RS03450_lanthipeptide
2
GPGYIETLTKDCPRVTPQICVPINGIWTCKRC
33
GPG ++TLTKDCP +CV + + TCK+C
2
GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC
33
41.2%
NZ_CP040409.1 and 3 others:
NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide
Lanthipeptides: FE336_RS03460_lanthipeptide
1
IGPGYIETLTKDCPRVTPQICVPIN
25
+GPG + TLTKDCP V P++C N
1
VGPGLVRTLTKDCPNVVPKVCFDGN
25

#### MIBiG 4.0 matches for IGY_RS28100

14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
8
TLTKDC
13
TLTK+C
20
TLTKEC
25
11.8%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
29
TCKRC
33
TC RC
2
TCARC
6
allorf_502069_502188
Leader:
MASSYTIKEKELIISFYG
Core:
KIFLIVIFYKSNFFHKCNYNS
Core with dehydrations:
KIFLIVIFYKDhaNFFHKCysNYNDha

#### antiSMASH-DB 4.0 matches for allorf_502069_502188

100.0%
NZ_KB976303.1:
Lanthipeptides: allorf_502069_502188_lanthipeptide
1
KIFLIVIFYKSNFFHKCNYNS
21
KIFLIVIFYKSNFFHKCNYNS
1
KIFLIVIFYKSNFFHKCNYNS
21
32.0%
NZ_MSRJ01000005.1:
Lanthipeptides: BKH06_RS03750_lanthipeptide
7
IFYKSNFFHKCNYNS
21
+FY F H+CN NS
4
VFYT--FTHECNTNS
16
22.2%
NZ_CP077726.1 and 16 others:
NZ_CP077726.1 Lanthipeptides: KTC92_RS18420_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18415_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18410_lanthipeptide NZ_CP077726.1 Lanthipeptides: KTC92_RS18405_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25465_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25460_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25455_lanthipeptide NZ_CP086142.1 Lanthipeptides: LL065_RS25450_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19070_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19065_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19060_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19055_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19050_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19045_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19040_lanthipeptide NZ_CP086248.1 Lanthipeptides: LL036_RS19035_lanthipeptide
Lanthipeptides: KTC92_RS18425_lanthipeptide
11
SNFFHKCNYNS
21
+ F H+C YNS
6
TTFTHECYYNS
16
with 2 more sequence matches
19.2%
NC_013928.1 and 9 others:
NC_013928.1 Lanthipeptides: SMUNN2025_RS01700_lanthipeptide NZ_CP023477.1 Lanthipeptides: CO204_RS01885_lanthipeptide NZ_CP023477.1 Lanthipeptides: CO204_RS01875_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01090_lanthipeptide NZ_CP050270.1 Lanthipeptides: HB753_RS01080_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01745_lanthipeptide NZ_CP061071.1 Lanthipeptides: IBL27_RS01735_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07575_lanthipeptide NZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS07565_lanthipeptide
Lanthipeptides: SMUNN2025_RS01710_lanthipeptide
15
HKCNYNS
21
H+C YNS
11
HECRYNS
17
16.1%
NZ_CP034248.1:
Lanthipeptides: EIM92_RS14995_lanthipeptide
15
HKCNYNS
21
H+C+YNS
15
HECHYNS
21
allorf_513973_514077
Leader:
MQLFAHTIIGR
Core:
LESLSLKNVQHFRFLREQFIQLC
Core with dehydrations:
LEDhaLDhaLKNVQHFRFLREQFIQLCys

#### antiSMASH-DB 4.0 matches for allorf_513973_514077

100.0%
NZ_KB976303.1:
Lanthipeptides: allorf_513973_514077_lanthipeptide
1
LESLSLKNVQHFRFLREQFIQLC
23
LESLSLKNVQHFRFLREQFIQLC
1
LESLSLKNVQHFRFLREQFIQLC
23
22.6%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: allorf_142674_142883_lanthipeptide
Lanthipeptides: allorf_142674_142883_lanthipeptide
1
LESLSLKNVQHFRFLR
16
+ESL+ H RF R
2
VESLAFGRWAHLRFGR
17
18.5%
NZ_NTSR01000029.1:
Lanthipeptides: allorf_57712_57837_lanthipeptide
7
KNVQHFRFLRE
17
KN+ HF+ + E
2
KNIHHFQIITE
12
with 2 more sequence matches
17.1%
NZ_CP017953.1 and 12 others:
NZ_CP021011.1 Lanthipeptides: allorf_1239450_1239680_lanthipeptide NZ_CP033054.1 Lanthipeptides: allorf_3724234_3724464_lanthipeptide NZ_CP041784.1 Lanthipeptides: allorf_3263499_3263729_lanthipeptide NZ_CP047268.1 Lanthipeptides: allorf_3744242_3744472_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_1130609_1130839_lanthipeptide NZ_CP072563.1 Lanthipeptides: allorf_3274357_3274587_lanthipeptide NZ_CP097784.1 Lanthipeptides: allorf_3221763_3221993_lanthipeptide NZ_CP116014.1 Lanthipeptides: allorf_3479615_3479845_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: allorf_316050_316280_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: allorf_123482_123712_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: allorf_273844_274074_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: allorf_316397_316627_lanthipeptide
Lanthipeptides: allorf_3287857_3288087_lanthipeptide
6
LKNVQHFRFL
15
LK +HFRFL
7
LKFPRHFRFL
16
13.5%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS16535_lanthipeptide
8
NVQHFRFLREQF
19
NV+ +F+R +F
21
NVKKLKFMRGEF
32

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.51 out of 18.16
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.07 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.37 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.79 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.24 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.17 out of 29.38
Confidence: medium
Additional weak hits (7):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.82 out of 29.65
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.15 out of 23.43
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.72 out of 32.74
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.91 out of 32.93
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.90 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Lanthipeptides
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

IGY_RS28100 - Class II
  Cleavage pHMM score: 2.90
  RODEO score: 0
  Monoisotopic mass: 3764.9 Da
  Molecular weight: 3767.5 Da
  Number of bridges: 4
allorf_502069_502188 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 2588.4 Da
  Molecular weight: 2590.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2608.1 Da N = 1
allorf_513973_514077 - Class II
  Cleavage pHMM score: -5.10
  RODEO score: 0
  Monoisotopic mass: 2811.5 Da
  Molecular weight: 2813.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2831.3 Da N = 1

Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 406038 - 515563:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Tyr) + (ohmal - bOH-Tyr) + (Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 406038 - >508651:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Tyr) + (ohmal - bOH-Tyr) + (Pro) + (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 468998 - 510455:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - ohmal) + (D-Asn) + (X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
IGY_RS27925: X - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (480..877): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSVAFDASIMEPVLFVGGELNAYGPTETTVCATM
  Nearest Stachelhaus code(s):
    Leu DAMLVGAVCK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1540..1944): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVSK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

IGY_RS27945: mal
PKS_AT (1897..2192): mal
ATSignature: 2-Rhyd-Malonyl-CoA

Top 3 matches:
  2-Rhyd-Malonyl-CoA: 95.8%
  Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 102.6
  inactive: 71.9
  Methoxymalonyl-CoA: 51.5
  Methylmalonyl-CoA: 43.0
  Propionyl-CoA: 32.4
  CHC-CoA: 15.7
  Ethylmalonyl-CoA: 14.8
  3-Methylbutyryl-CoA: 13.5
  2-Methylbutyryl-CoA: 13.4
  Isobutyryl-CoA: 11.7
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0

IGY_RS27950: bOH-Tyr - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (274..685): bOH-Tyr
nrpys: bOH-Tyr

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLSFDASVQNGDGIIAGETNAYGPTETTVDSTC
  Nearest Stachelhaus code(s):
    bOH-Tyr DASTIAAVDK (62% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1329..1728): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDVSVLEGNFLLAGEENMYGPTEATVIAST
  Nearest Stachelhaus code(s):
    Ala DVHNLAIVYK (76% 8Å match)
    Ser DVWNVAMVHK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

IGY_RS27975: mal
PKS_AT (5..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 51.2
  inactive: 31.2
  Methoxymalonyl-CoA: 30.8
  Methylmalonyl-CoA: 13.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

IGY_RS27995: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (8..410): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFVSGETNLYGPTEATIDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

IGY_RS28000: X - mal
AMP-binding (448..845): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHQHFDMSVWEGNQTFGGEVNMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Ser DMWNTGLVHK (82% 8Å match)
  Stachelhaus code match:
    90% (moderate)

PKS_AT (1551..1847): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 100.0%
  inactive: 83.3%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 134.0
  inactive: 99.8
  Methoxymalonyl-CoA: 44.9
  Methylmalonyl-CoA: 26.5
  Propionyl-CoA: 16.7
  Isobutyryl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

IGY_RS28020: Asn
Search NORINE for peptide: strict or relaxed
AMP-binding (461..856): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKVIVGGEINEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

IGY_RS28030: X - X
Search NORINE for peptide: strict or relaxed
AMP-binding (280..682): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMSFDVTIFEVYIFVGVELNGYGPTEATVCCTT
  Nearest Stachelhaus code(s):
    Met DVFYLGGVFK (59% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1323..1559): X
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMSFDVTIFEVYI--------------------
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes